4u3m 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......(..(((....]]]]]]]].)))..).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Anisomycin bound to the yeast 80S ribosome; 18S rRNA 4u3m 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<.<<........>.>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<..<<<......>>>....>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<...<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>...>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((...(....(.........)....).......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. Crystal structure of Anisomycin bound to the yeast 80S ribosome; 25s rRNA 4u3m 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3m 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3m 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Anisomycin bound to the yeast 80S ribosome; 18S rRNA 4u3m 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(((.......))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(.(...)..)..)))....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Anisomycin bound to the yeast 80S ribosome; 25s rRNA 4u3m 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3m 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3n 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..(......)..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3n 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))..))))).. Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3n 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3n 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u3n 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3n 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((..(((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))..).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))..........(....(...).....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3n 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3n 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u3u 2 1750 2.9 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<..<.<..........>.>..>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3u 1 3149 2.9 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3u 3 121 2.9 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3u 4 158 2.9 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u3u 6 1795 2.9 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3u 5 3150 2.9 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3u 7 121 2.9 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3u 8 158 2.9 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4n 2 1750 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(.(....).).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((........((((.........)))).....))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Edeine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4n 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of Edeine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4n 3 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Edeine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4n 4 158 3.1 RF00002 URS00001BF64E_4932 25209664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Edeine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4n 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.....(....).....)))).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Edeine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4n 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((....(...).....)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Edeine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4n 7 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Edeine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4n 8 158 3.1 RF00002 URS00001BF64E_4932 25209664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Edeine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4o 2 1750 3.6 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<.<......>...............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<<........>>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(.(.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((............)))))(.(.((((((......[[[[[[[[.((....))......(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))).).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))........(..............)............((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((....(())....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(....(((....]]]]]]]].)))....)...).....))...(((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.((...((((((((.(((........)))))))))))...))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((...((.(..(((..(((((......((........))..........(((((......(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((.(..(((((.((((((....))))))...)))))..).)).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))..))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..).))......(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((.......((.)).......)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Geneticin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4o 1 3149 3.6 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>.....{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<......<<<<......>>>>.(.......<<<......)>>>.....>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((.((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)).))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(...(((....))).............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(.....((.........)).....).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.(((((((((.((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))).).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..(((((..(...((.....((((....)))).....)).).)))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))...(((((.....((((..(((..........)))...........>...((((........))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(...(......)...)..)))))...)))....)))).)))))).))))).. Crystal structure of Geneticin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4o 3 121 3.6 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.....<.<<<<<..<<....>>.>>>>>...>.>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Geneticin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4o 4 158 3.6 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]]..............)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Geneticin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4o 6 1791 3.6 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<............>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<....<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[...(....)................)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(..((((................))))...)....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((...........(.(....))...........))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((.(.....]]].]]].).)))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((.(....(...((((.........))))...).).))))......<...(((.((.(((..((((((((.(.(........).)))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.....(((.((..(.((((((((.(((..(.((..(...(((((((.(....................).)))))))...)..)).)..))).)))))))))..)).)))..))...)..)..(((((((((....)))))))))>........ Crystal structure of Geneticin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4o 5 3150 3.6 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>.....{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><.<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>..>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<....<<<<<....>>>>.>...>>>>.>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{..[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]....}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((..........((.((((((...)))))).)).............((((((.((((((((..(((.(((((.(...({((((......)))))[[(...).(((....}]])))....).)))))...)))..).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((............(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((.(....).)))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((.((((.((((...(((((((....)))))))...).)))...(((..((.((.......A)))).)))..).))).))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((....(...).....)))....))....))...(((((........)))))]]((((..(((((.(....(((....))).....[.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....)))))).........).))..))).)))).))).))).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)...(((((.....((((..((((........))))...........]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(...((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............))...).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Geneticin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4o 7 121 3.6 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Geneticin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4o 8 158 3.6 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Geneticin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4q 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4q 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....))))).(.((((((((((.(...)))))..)))))).).(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4q 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4q 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4q 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<.........>...>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[.[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]].]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((........................)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4q 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<.<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..................)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4q 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4q 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4r 2 1750 2.801 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4r 1 3149 2.801 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<.<<<......>>>...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4r 3 121 2.801 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4r 4 158 2.801 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4r 6 1795 2.801 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4r 5 3150 2.801 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4r 7 121 2.801 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4r 8 158 2.801 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4u 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Lycorine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4u 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Lycorine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4u 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lycorine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4u 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lycorine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4u 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(.....(....).....).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Lycorine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4u 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Lycorine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4u 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lycorine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4u 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lycorine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4y 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((.(((.......))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Pactamycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4y 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(...((..)..)...)..)))))...)))....)))).)))))).))))).. Crystal structure of Pactamycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4y 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4y 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4y 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Pactamycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4y 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(.(.......).).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(((...)).)..)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(.(..........).).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Pactamycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4y 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4y 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4z 2 1750 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((....(.....................)....)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4z 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<.<<<<......>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))...(((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.((((..)..))).)..)))))...)))....)))).)))))..))))).. Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4z 3 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4z 4 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4z 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<.<<<<...............>>>>.....>>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(((((...............))))....).))).))))))....((((((....((..(((.(.....).)))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((...((((.((((((....))))))...))))...)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4z 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(..(((.....)))..).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(........)..)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4z 7 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4z 8 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u50 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Verrucarin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u50 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...(.((.((((.(......))))).)).).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Verrucarin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u50 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u50 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u50 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<.<..<<..<<<<.......>>>>..>>...>>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<.........>...>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(.....(....).....).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).))))))..)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Verrucarin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u50 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<...<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>.......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(.(((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))..).)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(.((.....)).).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..................)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Verrucarin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u50 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u50 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u51 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(.(....).).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.(..))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Narciclasine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u51 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<.<<<<......>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Narciclasine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u51 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u51 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u51 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>....<........>)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(....(..((........((.(((........))).))......))..)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((...(..................)...))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Narciclasine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u51 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<..<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..(((..........)))...........>...((((.(....).))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Narciclasine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u51 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u51 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.......<<<......>>..............>>>......>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u52 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<..<.<..........>.>..>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......(..(((....]]]]]]]].)))..).....).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 18S ribosomal RNA 4u52 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<..<<<......>>>....>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((............))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 25S ribosomal RNA 4u52 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5S ribosomal RNA 4u52 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u52 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<........>)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 18S ribosomal RNA 4u52 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((.(....).))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 25S ribosomal RNA 4u52 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5S ribosomal RNA 4u52 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u53 2 1750 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[..(....).......(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..)))................((.(((....]]]]]]]].))).))...........))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 18S ribosomal RNA 4u53 1 3149 3.3 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<.}}}..>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((..(((...(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).....))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(....(..)......)..)))))...)))....)))).)))))).))))).. Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 25S ribosomal RNA 4u53 3 121 3.3 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5S ribosomal RNA 4u53 4 158 3.3 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u53 6 1795 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]].]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((...((.((((((......((........))..........(((((.(....(((.(........((.(((........))).))......).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))..(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 18S ribosomal RNA 4u53 5 3150 3.3 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<.<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((....(...).....)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.(((((((.((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......)))))))))))...))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 25S ribosomal RNA 4u53 7 121 3.3 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5S ribosomal RNA 4u53 8 158 3.3 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u55 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.(.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..).)))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u55 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.....(.....)......)....))....))...(((((........)))))]]((((..(((.(.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).)...))).)))).)))..)).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))..))))).. Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u55 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u55 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u55 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>....<<......>>)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((.(.....]]]]]]].).)))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((........................)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u55 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<.<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u55 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u55 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u56 2 1750 3.45 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[.((....))......(......).)))))).)...).(.((((.(((.(....)))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((....(.....................)....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......(..(((....]]]]]]]].)))..).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.((...((((((((.(((........)))))))))))...))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((.(......((.....((..((((....))))..))....)).......).)))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 18S ribosomal RNA 4u56 1 3149 3.45 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<.<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........((((((.....)))))).....))).......((((((...(((((....(((......)))....))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 25S ribosomal RNA 4u56 3 121 3.45 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5S ribosomal RNA 4u56 4 158 3.45 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u56 6 1795 3.45 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[.[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.(.((((.....]]].]]].)))).).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..((.....(.....)......))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 18S ribosomal RNA 4u56 5 3150 3.45 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<..<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((((((((.((((((...({((((......)))))[[(...).(((....}]])))....))))).))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(((.......))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 25S ribosomal RNA 4u56 7 121 3.45 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5S ribosomal RNA 4u56 8 158 3.45 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u6f 2 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<..<.<..........>.>..>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<...<.........>....>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((....(....)....)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u6f 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((....(((......)))....))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u6f 3 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u6f 4 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u6f 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((.(.....]]].]]].).)))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((.....(.....)......)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u6f 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<.<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(.(...)..)..)))....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u6f 7 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u6f 8 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4v7r A1 1789 4.0 RF01960,RF01959,RF00177 URS00005F2C2D_4932 21109664 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuuuuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...{{{{>>>>>{{{...[[[[[................[[[.[[[..<<...<.<.....<<..........>>..>.>>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((.......<<<<<<<<<<<..>>>>..............))))))..........<<<..<<<.....>>>.>>>.....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<.<<..<....>..>.>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..]]]]]..}}}.........[[[<<.......{{...[[[.{{....<<<<<<.<<<.<..................>.>>>.>>>>>>.....<<<<.....<...<<<<.......>>>>...>.....>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[.[...((((.....>>>>>>>...))))..].]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.....<<<......>>>........>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<..<<<<<<<.<<<........>>>>>>>>>>...>>>>..<<..>>>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..}}}}..<<<<.<<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<.<<<<....<<<<<<<<<<....>>>>>.>>.>>>....>>>>>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<....<......<<.............................>>.....>..>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))((((..((.((...(.(...((..{..(((.(((..(....(((.....((.(......).))..))).)......(((.......(((..((..((....(((..................(.....((.(((.....))).))......)............((..((....))..))...(.(.((((((......[.[[[[[[(((....))).....(......).)))))).)...).....((...((.....))..))......)))...))))..))).(((....(((....((((((((.......)))))))))))......)))....(((((((....))))...))).))).((.(((..........))).)).(.((....)).)...)))))).)...}.(.(((...((((.....))).))))).)....).).....(.(((((.(.(((....))).).))).)).)......((..(..(......).)..)).........((((([[......((((.....((..]])).......)))).)))))..)).)).))).)........((({{.....(.((...(((.(......(.(((.(.((....................)).).))).).......((...........(((.......)))...........)).......(((.((.......((..............(((.....)))....))......)).))..)...............(.....(......]]]]].]]...)....)..........)...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((.(.........).))...).))))))......<...(((.((.((((..((.((((.((..........)))))).))...))))..((..}}))...)).....))).)))..((.......(((....))).....))....]]]..(.((..(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((..((.((((((....(((.(((((....)))....((......))....)).)))....(((((.(((.(((...((.((.((((((....))))))...)).))...))))))..(.((((((.....))))))....)..)))))....))).))).....))))))).....).)))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...))))))).))..)..(.(..((.(..((((.((..(.((((((((.(((..(.((..(.......(..............................).......))).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Yeast 80S ribosome.; 18S ribosomal RNA 4v7r B1 3206 4.0 RF02540,RF02543 URS000061F377_559292 21109664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<<...<<.<<.<<<<<<...>>>>>>.>>.>>...>>>......<<<<<.<<<<<<..<<<.<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>...>>>..>>....>>>>>>>>>..........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<<.....>>....................................<<<<<.<<<<<.<.......<<<<<<.....<<<.<..<<<<<......<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>...>>>>>..>.>>>............<<<....>>>......>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.........<<<<..<<<<....>>>>..>.>>>...<<<<<<<................>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.<<.<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<...........>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<<........>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<....<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>....>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<..<<<<<..........<<<<<..<<<..>>>............>>>>>.>>>>>...>>>>>>>>>>...<<<<<.....<<<<..<<<.<......>.>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]......<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.....>>>>>.........<<<<<<.<<<.<<................<<<<<.......>>>>>...............<<<<<.<<..<<<<.<..<<<......>>>..>.>>>>>>.>>>>>.............>>.>>>.>>>>>>...<<<<.....................<<<<<<<<..<<....<<<<<....<<<..........>>>...>>>>>...>>....>>>..>>>>>..>>.>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(....(.((.((((((...)))))).)).)....).........((((.((((.(..(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))..).....))))))))......)....(((((((........)))))))......((((..[[[.[[))))...)))..................................((....))............(..((.(....).))............).....................(((((.(((((.(.......(((((((.(.((((.(..(((((.......(((.(((....(..(((.(....).)))....)...))).))).....)))))..).))).).)........(((....))).....)))))))....)))))).)))))..((((........))))((((((....((((((.((((((..((((..((((.....))))..))))...((....)).........(((...((((....))))....)))...(((.(((....(......)....)).).).))....)))))).))))))..((.(...((((((.....(((((.(((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))).))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((((((((....(((.(((((((.....(((.....((..(.(((.(.(...(((.....)))...))))).)..))...)).).....)))))...((((.((((.(......))))).)))).....)))))..))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.................(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]]......))))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((.......(((.((((....)))))))....))))))))))..).....))))))((......(.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....))).........(((((........))))).....))....))...(((((........)))))]]((((.((((.(..(..((((....)))...(...((((((...((((.((((((((((((((((((...{...))))))((..((((.....(((((.....(((.....))).....)))))......))))...))((((((((....)))))))))))).).))))))).))))(...)....))))))...)).....)..).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((.(...).)))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)).[..(((((.......])))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((.(((..((((........[..(((((..((....))..........].)))))..))))...))).))).))....((((.....((((..(((((......)))))...............((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((.......))))..))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....).....))))..)))))).......((.(.(.((((.(...((.......))...).))))...)).).).......((.((.((((((..(..((((((......))))))....).(((.(.....).))).....)))))..)...))..))....(((((((....))).))))..>.))..))).))))).....((((((...((((...((((((.....(....)....))))))..(((((...((((....((((((((((.}..)))))..)))))...))))..))))).((((...((((.............))))...)))).)))).....))))))........(.((((.(((.((....((.(.........(((((.....)))).)....).)).......((.((.((..(..(.(..(((......)))..).)..))).)).)).............)).))).)))).)...((((.(..(.......)..).....(.((((((..((....(((((....((((........))))...)))))...))....)))..))).)..)).)).. Yeast 80S ribosome.; 25S ribosomal RNA 4v7r B2 121 4.0 RF00001 URS000055688D_4932 21109664 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<<.<.................>...>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>. (.((((.((....((((((((.....((.......................))....)))))).)).(((((.......(((((..((....)).))))).....))))).)).)))).). Yeast 80S ribosome.; 5S ribosomal RNA 4v7r B3 158 4.0 RF00002 URS00001BF64E_4932 21109664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<........>>>.....<<.<<......................>>>..>...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((..[.....))).....(..((.........]............))...)...)))....(((...)))(((((((((....)))))))))..................... Yeast 80S ribosome.; 5.8S ribosomal RNA 4v7r C1 1789 4.0 RF01960,RF01959,RF00177 URS00005F2C2D_4932 21109664 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuuuuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...{{{{>>>>>{{{...[[[[[................[[[.[[[..<<...<.<.....<<..........>>..>.>>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............))))))..........<<<..<<<.....>>>.>>>.....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<.<<..<....>..>.>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..]]]]]..}}}.........[[[{{.......{{...[[[.{{....<<<<<<.<<<.<..................>.>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[.[...((((.....>>>>>>>>..))))..].]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.....<<<......>>>........>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<..<<<<<<<.<<<........>>>>>>>>>>...>>>>..<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}...<<<.<<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<.<<<<....<<<<<<<<<<....>>>>>.>>.>>>....>>>>>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<....<......<<.............................>>.....>..>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))((((.(((.((...(.(...((..{..(((.(((..(....(((.....((.(......).))..))).)......(((.......(((..((..((....(((..................(.....((.(((.....))).))......)............((..((....))..)).....(.((((((......[.[.[[[[(((....))).....(......).)))))).).........((...((.....))..))......)))...))))..))).(((....(((....((((((((.......)))))))))))......)))....(((((((....))))...))).))).((.(((..........))).)).(.((....)).)...)))))).)...}.(.(((...((((.....))).))))).)....).).....(.(((((.(.(((....))).).))).)).)......((..(..(......).)..)).........((((([[......((((.....((..]])).......)))).)))))..)).)))))).)........((({{.....(.((...(((.(......(.(((.(.((....................)).).))).)......(((((....(...((((.......))))...)....)))))......(((.((.......((..............(((.....)))....))......)).))..)...............(.....(......]]]]..]]...)....)..........)...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.((((..((.((((.((..........)))))).))...))))..((..}}))...)).....))).)))..((.......(((....))).....))....]]]..(.((..(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((..((.((((((....(((.(((((....)))....((......))....)).)))....(((((.(((.(((...((.((.((((((....))))))...)).))...))))))..(.((((((.....))))))....)..)))))....))).))).....))))))).....).)))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...))))))).))..)..(.(..((.(..((((.((..(.((((((((.(((..(.((..(.......(..............................).......))).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Yeast 80S ribosome.; 18S ribosomal RNA 4v7r D1 3206 4.0 RF02540,RF02543 URS000061F377_559292 21109664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<<...<<.<<.<<<<<<...>>>>>>.>>.>>...>>>......<<<<<.<<<<<<..<<<.<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>...>>>..>>....>>>>>>>>>..........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<<.....>>....................................<<<<<.<<<<<.<.......<<<<<<.....<<<.<..<<<<<......<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>...>>>>>..>.>>>............<<<....>>>......>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.........<<<<..<<<<....>>>>..>.>>>...<<<<<<<................>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.<<.<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<...........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........)))..>...>>>>>>.>>>>..>>>>>>><<<<<<<<...........>>>>>>>>....>>>>>>...<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>.........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<<........>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<....<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>....>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<..<<<<<..........<<<<<..<<<..>>>............>>>>>.>>>>>...>>>>>>>>>>...<<<<<.....<<<<..<<<.<......>.>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]......<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.....>>>>>.........<<<<<<.<<<.<<................<<<<<.......>>>>>...............<<<<<.<<..<<<<.<..<<<......>>>..>.>>>>>>.>>>>>.............>>.>>>.>>>>>>...<<<<.....................<<<<<<<<..<<....<<<<<....<<<..........>>>...>>>>>...>>....>>>..>>>>>..>>.>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(....(.((.((((((...)))))).)).)....).........((((.((((.(..(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))..).....))))))))......)....(((((((........)))))))......((((..[[[.[[))))...)))..................................((....))............(..((.(....).))............).....................(((((.(((((.(.......(((((((.(.((((.(..(((((.......(((.(((....(..(((.(....).)))....)...))).))).....)))))..).))).).)........(((....))).....)))))))....)))))).)))))..((((........))))((((((....((((((.((((((..((((..((((.....))))..))))...((....)).........(((...((((....))))....)))...(((.(((....(......)....)).).).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((((((((....(((.(((((((.....(((.....((..(.(((.(.(...(((.....)))...))))).)..))...)).).....)))))...((((.((((.(......))))).)))).....)))))..))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.................(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]]......))))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((.......(((.((((....)))))))....))))))))))..).....))))))((......(.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....))).........(((((........))))).....))....))...(((((........)))))]]((((.((((.(..(..((((....)))...(...((((((...((((.((((((((((((((((((...{...))))))((..((((.....(((((.....(((.....))).....)))))......))))...))((((((((....)))))))))))).).))))))).))))(...)....))))))...)).....)..).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((.(...).)))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)).[..(((((.......])))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((.(((..((((........[..(((((..((....))..........].)))))..))))...))).))).))....((((.....((((..(((((......)))))...............((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((.......))))..))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....).....))))..)))))).......((.(.(.((((.(...((.......))...).))))...)).).).......((.((.((((((..(..(((((........)))))....).(((.(.....).))).....)))))..)...))..))....(((((((....))).))))..>.))..))).))))).....((((((...((((...((((((.....(....)....))))))..(((((...((((....((((((((((.}..)))))..)))))...))))..))))).((((...((((.............))))...)))).)))).....))))))........(.((((.(((.((....((.(..........((((.....))))......).)).......((.((.((..(..(.(..(((......)))..).)..))).)).)).............)).))).)))).)...((((.(..(.......)..).....(.((((((..((....(((((....((((........))))...)))))...))....)))..))).)..))).).. Yeast 80S ribosome.; 25S ribosomal RNA 4v7r D2 121 4.0 RF00001 URS000055688D_4932 21109664 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<<.<.................>...>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>. (.((((.((....((((((((.....((.......................))....)))))).)).(((((.......(((((..((....)).))))).....))))).)).)))).). Yeast 80S ribosome.; 5S ribosomal RNA 4v7r D3 158 4.0 RF00002 URS00001BF64E_4932 21109664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<........>>>.....<..<<......................>>...>...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((..[.....)))....((..((.........]............))...).).)))....(((...)))(((((((((....)))))))))..................... Yeast 80S ribosome.; 5.8S ribosomal RNA 4v88 A2 1781 3.0 RF01960,RF01959,RF00177 URS000080DE56_4932 22096102 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<<........>>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<..................>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... 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The structure of the eukaryotic ribosome at 3.0 A resolution.; 18S RIBOSOMAL RNA 4v88 A1 3149 3.0 RF02540,RF02543 URS000061F377_4932 22096102 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. The structure of the eukaryotic ribosome at 3.0 A resolution.; 25S rRNA 4v88 A3 121 3.0 RF00001 URS000055688D_4932 22096102 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). The structure of the eukaryotic ribosome at 3.0 A resolution.; 5S rRNA 4v88 A4 158 3.0 RF00002 URS00001BF64E_4932 22096102 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... The structure of the eukaryotic ribosome at 3.0 A resolution.; 5.8S rRNA 4v88 A6 1795 3.0 RF01960,RF01959,RF00177 URS000080E2AF_4932 22096102 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<................>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... 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The structure of the eukaryotic ribosome at 3.0 A resolution.; 18S rRNA 4v88 A5 3150 3.0 RF02540,RF02543 URS000061F377_4932 22096102 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. The structure of the eukaryotic ribosome at 3.0 A resolution.; 25S rRNA 4v88 A7 121 3.0 RF00001 URS000055688D_4932 22096102 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). The structure of the eukaryotic ribosome at 3.0 A resolution.; 5S rRNA 4v88 A8 158 3.0 RF00002 URS00001BF64E_4932 22096102 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... The structure of the eukaryotic ribosome at 3.0 A resolution.; 5.8S rRNA 4v8e AA 2912 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.<......>.>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((........)))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((..((......))...))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; RNA (2912-MER) 4v8e AB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 5S RIBOSOMAL RNA 4v8e BA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.<.....>>>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.........)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(.((...)).).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.(((......))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..((.(((((....))))).)...)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 16S ribosomal RNA 4v8e BB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8e BC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-FMET 4v8e BD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8e CA 2907 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((.((((.[.....)))).))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.......{.(((((.(((..(((.........)))..))).....(...((......)).).))))).....)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; RNA (2912-MER) 4v8e CB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 5S RIBOSOMAL RNA 4v8e DA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.((...)).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(.......(((.....)))......).)))))...(.(((((....))))).)......)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 16S ribosomal RNA 4v8e DB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8e DC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-FMET 4v8e DD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8f AA 2912 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc 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((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; RNA (2912-MER) 4v8f AB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 5S RIBOSOMAL RNA 4v8f BA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.<.....>>>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.........)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(.((...)).).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))........(.(((((((..(...((((((((..(((((((....))))))).(.(((......))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(....(..(((.....)))).....).)))))...(.(((((....))))).)......)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 16S ribosomal RNA 4v8f BB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((.(..(((...........))).(((((.......))))).(((...)))...(((((.......)))))).))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f BC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-FMET 4v8f BD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f CA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....)))))))...((((....))))..))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(.......(((.....)))......).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 16S ribosomal RNA 4v8f CB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... ((.((((..((.............)).(((((.......))))).(((...)))...(((((.......))))))))).)).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f CC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-FMET 4v8f CD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[..[..))).(((((.......))))).(((...)))]..(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f DA 2907 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; RNA (2912-MER) 4v8f DB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......)))..)))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 5S RIBOSOMAL RNA 4v8y B2 1781 4.3 RF01960,RF01959,RF00177 URS000080DE56_4932 24200810 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagannnnnnnnnnnnnnucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<<........>>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<..................>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((.(....................).)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 18S RIBOSOMAL RNA 4v8y B5 3147 4.3 RF02540,RF02543 URS000061F377_4932 24200810 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<..........<<<...<<.........>>...>>>.........<<......>>...........>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((..........(((...((.........))...))).....(...((......)).).........)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 25S RIBOSOMAL RNA 4v8z B2 1781 6.6 RF01960,RF01959,RF00177 URS000080DE56_4932 24200810 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<<........>>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<..................>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... 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Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 18S RIBOSOMAL RNA 4v8z B5 3147 6.6 RF02540,RF02543 URS000061F377_4932 24200810 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((..........(((...((.........))...))).....(...((......)).).........)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 25S RIBOSOMAL RNA 4v8z B7 121 6.6 RF00001 URS000055688D_4932 24200810 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 5S RIBOSOMAL RNA 5dat 2 1781 3.15 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<...<<.<..........>.>>....>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<.<<<..<<..................>>..>>>.>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... 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Complex of yeast 80S ribosome with hypusine-containing eIF5A; 18S ribosomal RNA 5dat 1 3149 3.15 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..............).)....))....))...(((((........)))))]]((((..(((.(.(...((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))....)....).)...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((.((.(...))).)..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((............))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((..(.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((....(((......)))....))))).)))))).............)).))).)..)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.((((..)..))).)..)))))...)))....)))).)))))).))))).. Complex of yeast 80S ribosome with hypusine-containing eIF5A; 25S ribosomal RNA 5dat 3 121 3.15 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5S ribosomal RNA 5dat 4 158 3.15 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5.8S ribosomal RNA 5dat 6 1795 3.15 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<.<..........>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<<.......>>...>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..(......)..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((...................))......))).))))))....((((((....(...(((((.....)))))...)....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((....((((((.....]]]]]]].))))))...))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(..((........((.(((........))).))......))..)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........(.....).........)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Complex of yeast 80S ribosome with hypusine-containing eIF5A; 18S ribosomal RNA 5dat 5 3169 3.15 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<.<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<.<<.....>>.>>>>>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<..<<<<<......>>>>>...>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((...(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(...((.....))...)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(........)..)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((......((......)).......))))))))....((((.....((((..((((........))))...........>...((((........))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(.(.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Complex of yeast 80S ribosome with hypusine-containing eIF5A; 25S ribosomal RNA 5dat 7 121 3.15 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5S ribosomal RNA 5dat 8 158 3.15 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5.8S ribosomal RNA 5dge 2 1781 3.45 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 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Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome; 5.8S ribosomal RNA 5dgf 1 3149 3.3 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<...<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>...>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.(((((((.((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......)))))))))))...))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((..(......)..)..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((............))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).)..((.(.....).))......)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(.(.((....((.(........(((((((..).)))))).....))).......((((((...(((((....(((......)))....))))).)))))).............)).).)....)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.((((..)..))).)..)))))...)))....)))).)))))).))))).. Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 25S ribosomal RNA 5dgf 5 3169 3.3 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<.<<<<<..<<<<.<.....>>>>>...>>>>>.>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((...(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(........)..).)....))....))...(((((........)))))]]((((.((((((.(...(.((....))....(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((...(((......(..(...).).......)))...))....((((.....((((..(.((........)).)...........>...((((........))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 25S ribosomal RNA 5fci 2 1781 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<...<.........>....>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[.[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((.....(((((.(((((.....().....))))).)))))......(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]].]].))).)).)...).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..((..................))..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fci 1 3149 3.4 RF02540,RF02543 URS000061F377_559292 26906928 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(.....((.........)).....).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 25S ribosomal RNA 5fci 3 121 3.4 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fci 4 158 3.4 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5fci 6 1795 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fci 5 3150 3.4 RF02540,RF02543 URS000061F377_559292 26906928 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 25S ribosomal RNA 5fci 7 121 3.4 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((.(((...(....)...)))....))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fci 8 158 3.4 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5fcj 2 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<...<.........>....>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..(......)..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((...((..................))...)).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fcj 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 26906928 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.....(.....)......)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.((((..)..))).)..)))))...)))....)))).)))))).))))).. Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 25S ribosomal RNA 5fcj 3 121 3.1 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fcj 4 158 3.1 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5fcj 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<........>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fcj 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 26906928 0003735 0005840 559292 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........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 25S ribosomal RNA 5fcj 7 121 3.1 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fcj 8 158 3.1 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5i4l 2 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 27296282 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<.<<<<.<<...<.........>....>>.>>>>.>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.((((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 18S ribosomal RNA 5i4l 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 27296282 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 25S ribosomal RNA 5i4l 3 121 3.1 RF00001 URS000055688D_559292 27296282 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5S ribosomal RNA 5i4l 4 158 3.1 RF00002 URS00001BF64E_559292 27296282 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5i4l 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 27296282 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((........................)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 18S ribosomal RNA 5i4l 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 27296282 0003735 0005840 559292 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.........................<<<<<.....<<....>>......>>>>>.....<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<.]]]..>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 25S ribosomal RNA 5i4l 7 121 3.1 RF00001 URS000055688D_559292 27296282 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5S ribosomal RNA 5i4l 8 158 3.1 RF00002 URS00001BF64E_559292 27296282 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5lyb 2 1781 3.25 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<...<.........>....>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((...(....................)...)).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 18S rRNA 5lyb 1 3149 3.25 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(....(.....)......)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 25S rRNA 5lyb 3 121 3.25 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5S rRNA 5lyb 4 158 3.25 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5.8S rRNA 5lyb 6 1795 3.25 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<.........>...>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((((.....(....).....)))).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 18S rRNA 5lyb 5 3150 3.25 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 25S rRNA 5lyb 7 121 3.25 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5S rRNA 5lyb 8 158 3.25 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5.8S rRNA 5mei 1 3149 3.5 RF02540,RF02543 URS000061F377_559292 28457705 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.........<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(...((..)..)...)..)))))...)))....)))).)))))..))))).. Crystal structure of Agelastatin A bound to the 80S ribosome; 25S ribosomal RNA 5mei 3 121 3.5 RF00001 URS000055688D_559292 28457705 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Agelastatin A bound to the 80S ribosome; 5S ribosomal RNA 5mei 4 158 3.5 RF00002 URS00001BF64E_559292 28457705 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Agelastatin A bound to the 80S ribosome; 5.8S ribosomal RNA 5mei 6 1783 3.5 RF01960,RF01959,RF00177 URS00005F2C2D_559292 28457705 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((................)))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(((((...))))....).))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(........((.(((........))).))......).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((..(..................)..)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Agelastatin A bound to the 80S ribosome; 18S ribosomal RNA 5mei AR 3149 3.5 RF02540,RF02543 URS000061F377_559292 28457705 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<<......<.....]....<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<.......>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(((..((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....)))..)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((.(.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).).))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))).))))).. Crystal structure of Agelastatin A bound to the 80S ribosome; 25S ribosomal RNA 5mei AS 121 3.5 RF00001 URS000055688D_559292 28457705 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Agelastatin A bound to the 80S ribosome; 5S ribosomal RNA 5mei AT 158 3.5 RF00002 URS00001BF64E_559292 28457705 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Agelastatin A bound to the 80S ribosome; 5.8S ribosomal RNA 5mei A 1781 3.5 RF01960,RF01959,RF00177 URS00005F2C2D_559292 28457705 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<....<..........>....>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<.<<<<.<<..................>>.>>>>.>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.(................).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((....(())....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.((....(....................)....).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Agelastatin A bound to the 80S ribosome; 18S ribosomal RNA 5on6 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 29429877 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<...<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>...>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(..(((.....)))..).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((.(.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).)...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(...((..)..)...)..)))))...)))....)))).)))))..))))).. Crystal structure of haemanthamine bound to the 80S ribosome; 25S ribosomal RNA 5on6 3 121 3.1 RF00001 URS000055688D_559292 29429877 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of haemanthamine bound to the 80S ribosome; 5S ribosomal RNA 5on6 4 158 3.1 RF00002 URS00001BF64E_559292 29429877 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of haemanthamine bound to the 80S ribosome; 5.8S ribosomal RNA 5on6 6 1783 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29429877 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<........>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))........(.(...........))............((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(((((...))))....).))).))))))....((((((....((..(((.........)))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of haemanthamine bound to the 80S ribosome; 18S ribosomal RNA 5on6 AR 3149 3.1 RF02540,RF02543 URS000061F377_559292 29429877 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<.......>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((.(((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..).))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(..(((.....)))..).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((............))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. Crystal structure of haemanthamine bound to the 80S ribosome; 25S ribosomal RNA 5on6 AS 121 3.1 RF00001 URS000055688D_559292 29429877 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of haemanthamine bound to the 80S ribosome; 5S ribosomal RNA 5on6 AT 158 3.1 RF00002 URS00001BF64E_559292 29429877 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of haemanthamine bound to the 80S ribosome; 5.8S ribosomal RNA 5on6 A 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29429877 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<....<..........>....>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<...<.........>....>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.(................).)....)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((..((((((....))))))....))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.((....(....................)....).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of haemanthamine bound to the 80S ribosome; 18S ribosomal RNA 5tbw 1 3149 3.0 RF02540,RF02543 URS0000B21DCE_559292 29064494 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.....(.....)......)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))..))))).. Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 25S ribosomal RNA 5tbw 3 121 3.0 RF00001 URS000055688D_559292 29064494 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5S ribosomal RNA 5tbw 4 158 3.0 RF00002 URS00001BF64E_559292 29064494 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5tbw AR 3149 3.0 RF02540,RF02543 URS0000B21DCE_559292 29064494 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<.......>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(....(.....)......)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((......))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 25S ribosomal RNA 5tbw AS 121 3.0 RF00001 URS000055688D_559292 29064494 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5S ribosomal RNA 5tbw AT 158 3.0 RF00002 URS00001BF64E_559292 29064494 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5tbw A 1781 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29064494 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<..<.<..........>.>..>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<...<.........>....>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 18S ribosomal RNA 5tbw sR 1783 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29064494 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..(((((...))))....)..)).))))))....((((((....((..(((.........)))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 18S ribosomal RNA 5tga 2 1781 3.3 RF01960,RF01959,RF00177 URS0000A7631D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucaucuuagagaagggggcaacuccaucucagagc ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.......<<<.<<...<.........>....>>.>>>. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((....(((............))).....))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.[.))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>......((..(....................)..))] Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tga 1 3149 3.3 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<.<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<.....<<<<...<<<<<<.....>>>>>>.>>>>.....>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<.....]....<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tga 3 121 3.3 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tga 4 158 3.3 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 5tga 6 1795 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<....[[[[.>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<................>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((((.....(....).....)))).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((..(..................)..)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tga 5 3150 3.3 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(.((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tga 7 121 3.3 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tga 8 158 3.3 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 5tgm 2 1781 3.5 RF01960,RF01959,RF00177 URS0000B21DFE_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucaucuuagagaagggggcaacuccaucucagagc ...<<<<....[[[[.>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.......<<<.<<...<.........>....>>.>>>. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((..(......)..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(..(...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((........(..((.......)).(((.....)))....).......)).))..))).........(....(....(((....]]]]]]]].)))....)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).)))......(((....)))..))))..)).))...))..))))...)..)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(.((..(((((.((((((....))))))...)))))..)).).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.[.))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>......((..(....................)..))] Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tgm 1 3149 3.5 RF02540,RF02543 URS0000B21DCE_4932 27827794 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<.]]]..>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..((((.((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)).)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((..(...).)))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((.(((....)))..)))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(.(.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).).)...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))..))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tgm 3 121 3.5 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tgm 4 158 3.5 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 5tgm 6 1795 3.5 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<..........>..>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... 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Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tgm 5 3150 3.5 RF02540,RF02543 URS0000B21DEF_4932 27827794 0003735 0005840 4932 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........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.((((((((((((...({((((......)))))[[......(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...(.((....))....(.<.((((((...((((.(((((((((.((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))).).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)...(((((.....((((..(.((........)).)...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).........(.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)....(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tgm 7 121 3.5 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tgm 8 158 3.5 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 6hhq 1 3149 3.1 RF02540,RF02543 URS000061F377_4932 30759226 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<.<<<......>>>...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.<>..>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Crystal structure of compound C45 bound to the yeast 80S ribosome; 25S ribosomal RNA 6hhq 3 121 3.1 RF00001 URS000055688D_4932 30759226 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of compound C45 bound to the yeast 80S ribosome; 5S ribosomal RNA 6hhq 4 158 3.1 RF00002 URS00001BF64E_4932 30759226 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of compound C45 bound to the yeast 80S ribosome; 5.8S ribosomal RNA 6hhq AR 3147 3.1 RF02540,RF02543 URS000061F377_4932 30759226 0003735 0005840 4932 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Crystal structure of compound C45 bound to the yeast 80S ribosome; 25S ribosomal RNA 6hhq AS 121 3.1 RF00001 URS000055688D_4932 30759226 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of compound C45 bound to the yeast 80S ribosome; 5S ribosomal RNA 6hhq AT 158 3.1 RF00002 URS00001BF64E_4932 30759226 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of compound C45 bound to the yeast 80S ribosome; 5.8S ribosomal RNA 6hhq A 1781 3.1 RF01960,RF01959,RF00177 URS0000D77925_4932 30759226 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<....<..........>....>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<..................>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((.(((.......))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(.(.((....(....)....)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....(.((((...............................)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of compound C45 bound to the yeast 80S ribosome; 18S ribosomal RNA 6hhq sR 1783 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_4932 30759226 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(.....(....).....).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(..((........((.(((........))).))......))..)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of compound C45 bound to the yeast 80S ribosome; 18S ribosomal RNA 7azo 16SA 1512 3.3 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 ggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucaccuccu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.((..(.....)..)).)).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(((...(((((......)))))....((((....))))..)).)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 16S rRNA 7azo ASIA 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>.>>>>>>>>.... ((...(...(..(.....[..)..).((((.........))))........((..]....))....)...)).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo PSIA 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo ESIA 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<..........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).)).((((.........)))).....(((...........)))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo MRNA 30 3.3 URS0002335939_300852 36827973 300852 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; RNA (30-MER) 7azo TRNA 73 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggca <<<<<<...<<............>>..<<<<<.....>>>>>......<<<<<.......>>>>>.>>>>>>. ((((.((..(..(........)..)(.(.(.........).)..).....(((.......)))..)).)))). 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo 23SA 2889 3.3 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 gucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggagcagccaucauuuaaagagugcguuagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<..>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<..<<<<<......>>>>.>..>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<.......>...>>.........<<....>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.<<..<<<.......<<<<<<<<..>>>>>>>>....>>>............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 23S rRNA 7azo 5SA 122 3.3 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 5S rRNA 7azo 16SB 1508 3.3 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 16S rRNA 7azo ASIB 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca .<<<<<.....<<........>>...<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>..... (..........((........).)..((((.........)))).....(..((.......))..)......).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo PSIB 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo ESIB 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((............)).(((((.......))))).....(.((.........)).)))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo 23SB 2873 3.3 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 23S rRNA 7azo 5SB 121 3.3 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 5S rRNA 7azs 16SA 1511 3.1 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 16S rRNA 7azs ASIA 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... ((...(...(..(.....[..)..).((((.........)))).....((.((..]....)).)).)...)).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs PSIA 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs ESIA 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<..........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).)).((((.........)))).....(((...........)))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs TRNA 73 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggca <<<<<<...<<............>>..<<<<<.....>>>>>......<<<<.........>>>>.>>>>>>. ((((.((..(..(........)..)(.(((.........)))..)...(.(((.......))).))).)))). 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs 23SA 2889 3.1 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 23S rRNA 7azs 5SA 122 3.1 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 5S rRNA 7azs 16SB 1507 3.1 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 16S rRNA 7azs ASIB 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca .<<<<<.....<<........>>...<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>..... (...(......((........).)..((((.........))))........((.......)).....)...).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs PSIB 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs ESIB 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((............)).(((((.......))))).....(.((.........)).)))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs 23SB 2875 3.1 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 23S rRNA 7azs 5SB 121 3.1 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......)))..)))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 5S rRNA 8p4v 1 3149 3.16 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<.......>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<<......<.....]....<<<.<<<<<<<<<<.......<<<<<..<....<<.........>>....>..........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<.<<<......>>>...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<.......>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((...(...((.........))...)...........(........)...)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((..............).)....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.(((((((((.((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))).).).))))))).))))(...)....))))))...))....).))..))).)))).)))..)).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(.(...)).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((...((..........))............>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(....(..)......)..)))))...)))....)))).)))))).))))).. 80S yeast ribosome in complex with HaterumaimideQ; 25S ribosomal RNA 8p4v 3 121 3.16 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S yeast ribosome in complex with HaterumaimideQ; 5S ribosomal RNA 8p4v 4 158 3.16 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S yeast ribosome in complex with HaterumaimideQ; 5.8S ribosomal RNA 8p4v AR 3147 3.16 RF02540,RF02541,RF02543 URS000061F377_4932 0003735 0005840 4932 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80S yeast ribosome in complex with HaterumaimideQ; 18S ribosomal RNA 8p4v sR 1783 3.16 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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80S yeast ribosome in complex with HaterumaimideQ; 18S ribosomal RNA 8p9a 1 3149 2.9 RF02540,RF02541,RF02543 0003735 0005840 4932 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80S yeast ribosome in complex with Methyllissoclimide; 25S ribosomal RNA 8p9a 3 121 2.9 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S yeast ribosome in complex with Methyllissoclimide; 5S ribosomal RNA 8p9a 4 158 2.9 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S yeast ribosome in complex with Methyllissoclimide; 5.8 ribosomal RNA 8p9a AR 3130 2.9 RF02540,RF02541,RF02543 0003735 0005840 4932 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(((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S yeast ribosome in complex with Methyllissoclimide; 5S ribosomal RNA 8p9a AT 158 2.9 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S yeast ribosome in complex with Methyllissoclimide; 5.8 ribosomal RNA 8p9a A 1741 2.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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80S yeast ribosome in complex with Methyllissoclimide; 16S ribosomal RNA 8p9a sR 1783 2.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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80S yeast ribosome in complex with Methyllissoclimide; 16S ribosomal RNA