3ol7 J 16 2.7 URS000080E368_32630 21148772 32630 caggucucucguccgg ................ ................ Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol7 N 16 2.7 URS000080E368_32630 21148772 32630 caggucucucguccgg ................ ................ Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3r2c S 10 1.902 URS000080DF91_63363 21652641 63363 ggcuccuugg .......... .......... Crystal Structure of Antitermination Factors NusB and NusE in complex with BoxA RNA; 5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3' 4ngd B 12 1.958 URS000080E150_32630 24486018 32630 gcgaauucgcuu ............ ............ Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having 5'-p and UU-3' ends (1.95 Angstrom resolution); 5'-R(P*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' 4ybb DA 2897 2.1 RF02540,RF02541 URS000080E25C_83333 25775265 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((........))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(............((...((......(.((((((....)))))).)...)).............))...)..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). High-resolution structure of the Escherichia coli ribosome; 23S rRNA 5aox C 87 2.04 RF00017 URS00008FED21_32630 26585389 0006617 0005786 32630 ngccgggcgcgguggcucacgccuguaaucccagcacuuugggaggccgaggcgggaggaucgcgaacacgcgagaccccgucucua <<<<<<<<<.<<..((>>.>>>>>....<<<<.)).....>>>>>>>><<<<<<<<.<..<<<<<....>>>>>..>>>>>>>>>.. (((((((((.(..[[[.).)))))....((((.]].]...))))))))((((((((.(..(((((....)))))..))))))))).. Human Alu RNA retrotransposition complex in the ribosome-stalling conformation; ALU JO CONSENSUS RNA 5it8 DA 2897 3.12 RF02540,RF02541 URS000080E25C_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........((.((...((......((((((((....))))))))...)).............)).))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). High-resolution structure of the Escherichia coli ribosome; 23S rRNA 5j5b DA 2897 2.8 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the WT E coli ribosome bound to tetracycline; 23S rRNA 5j7l DA 2897 3.0 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<<<....<<<<<<<<....>>>>>>>>.>>>>>............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 23S rRNA 5j88 DA 2897 3.32 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<.<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>..>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........((((....((......((((((((....))))))))...))..............))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 23S rRNA 5j8a DA 2897 3.1 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 23S rRNA 5j91 DA 2897 2.96 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 23S rRNA 5jc9 DA 2897 3.03 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<.<<<..<<<<<....<<<<<<<<....>>>>>>>>.>>>>>............>>>..>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 23S rRNA 6i7v DA 2897 2.9 RF02540,RF02541 URS000080E25C_562 30359641 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....................>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<....<<......<<<<<<<<....>>>>>>>>...>>..............>>>.>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((...(............)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((.((.((((.((.....)))))).))...))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((..(((...........((.(....((......(((..............)))...))..............).))..)))..))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Ribosomal protein paralogs bL31 and bL36; 23S ribosomal RNA