5t83 A 90 2.71 RF00442 URS0000B21DF2_679936 28017522 0010468 679936 aaguuugcuaggguuccgcgucauagguggucugguccaagagcaaacggcuuucacaaagccacacggaaggauaaaagccugggagau ..<<<<<<..<<...<<<<<<.....>>>...>>>.>>....>>>>>><<<<<.....>>>>>...<...<<<.......>>>....>.. ..((((((..((...(((((((...))))..).)).))....))))))((((.......)))).[.(....((.......))..]..).. Structure of a guanidine-I riboswitch from S. acidophilus; RNA (95-MER) 8ogj 1 3126 3.1 RF02543 URS0000C2FD9C_5476 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggcuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<..>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<..>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((()))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(())..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((..(....((.........))....)......(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((.(....).)))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))...(((((.....((((..(((((......)))))...........>..((((...))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((..(....((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).)))))).............)..))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Structure of Candida albicans 80S ribosome in complex with mefloquine; 25S ribosomal RNA 8q5i 1 3073 2.45 RF02543 URS0000C2FD9C_5476 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggcuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucggaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<..>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<..>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<..>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<...........>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<..<....<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((()))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(())..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.((()))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))...(((((.....((((..(((((......)))))...........>..((((...))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of Candida albicans 80S ribosome in complex with cephaeline; 25S rRNA 9g1z 1 3147 3.1 RF02543 40273100 0003735 0005840 237561 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuuggggccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<....<<<<...>>>>....>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<..>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<<....<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..(((...................)))).((((((((((((((((.(((((((........((((((......((((.(......).)))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....((()))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((.((....((.........))....)).....(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(((((......)))))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))...(((((.....((((..(((((......)))))...........>..((((...))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((..(....((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).)))))).............)..))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of Candida albicans 80S ribosome in complex with mefloquine (non-rotated state); 25S rRNA 9g30 1 3066 2.35 RF02543 40273100 0003735 0005840 5476 gaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggcuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuaaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu ......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<...<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>.>..>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<..>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<..<<<..>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<....>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<<....<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((.(.((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))).))....))))).)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((()))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.(((...(.(()).).))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))......))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(()).)))))))...(((((.....((((..(((((......)))))...........>..((((...))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).....((((((.(((..(....((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).)))))).............)..))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. The structure of the Candida albicans ribosome with tRNA-fMet, mRNA, and compounds (GEN and MFQ) shows strong density for the A site tRNA; 25S rRNA 9g6j 1 3066 2.15 RF02543 40273100 0003735 0005840 237561 gaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggcuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuaaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu ......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<.<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>.>..>>>>>>>>....>>>>>.>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<..>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<..<<....>>>..>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<..<<<..>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<....>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<......>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<<....<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((.(.((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))).)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((()))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.(((...(......).))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((())))))))))...(((((.....((((..(((((......)))))...........>..((((...))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).....((((((.(((..(....((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).)))))).............)..))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. The structure of the Candida albicans ribosome with tRNA-fMet, mRNA, and compounds (GEN and MFQ) with strong density for the P-site tRNA; 25S rRNA