1f1t A 38 2.8 URS000080DE28_32630 10926496 32630 ggancccgacnggcgagagccaggnaacgaanggancc <<<<<<<<.<<<<<....>>>>>....>>...>>>>>> ((((((((.(((((....)))))....))...)))))) CRYSTAL STRUCTURE OF THE MALACHITE GREEN APTAMER COMPLEXED WITH TETRAMETHYL-ROSAMINE; MALACHITE GREEN APTAMER RNA 1nuv C 13 1.81 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuv E 13 1.81 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1vc0 B 73 2.5 RF00094 URS000080E29B_32630 15141216 3.1.-.- 0004540 32630 uggccggcauggucccagccuccucgcuggcgccggcugggcaacaccauugcacuccgguggugaaugggac .<<<<<<<...((((((<<<.((.....>>>>>>>>>>))....<<<<..........>>>>.....)))))) .(((((((...[[[[[[(((.[[.....))))))))))]]....((((..........)))).....]]]]]] Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Imidazole and Sr2+ solution; Hepatitis Delta virus ribozyme 1vq8 0 2754 2.2 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq8 9 122 2.2 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq9 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq9 9 122 2.4 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqk 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqk 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vql 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DCSN"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vql 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DCSN"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqm 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DAN"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqm 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DAN"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqn 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 16306996,16285925 0003735 0005840 2238 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..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqn 9 122 2.4 RF00001 URS00003592C7_2238 16306996,16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqo 0 2754 2.2 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCPMN bound to the large ribosomal subunit haloarcula marismortui; 23S ribosomal rna 1vqo 9 122 2.2 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCPMN bound to the large ribosomal subunit haloarcula marismortui; 5S ribosomal RNA 1vqp 0 2754 2.25 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""RAP"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqp 9 122 2.25 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""RAP"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1yhq 0 2754 2.4 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yhq 9 122 2.4 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 2pn4 A 24 2.32 URS000080DF3C_32630 18391410 32630 cggaggaacuacugucuucacgcc ........................ ........................ Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' 2pn4 C 24 2.32 URS000080DF3C_32630 18391410 32630 cggaggaacuacugucuucacgcc ........................ ........................ Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' 3cc4 0 2754 2.7 RF02540,RF00002 URS000080E102_2238 18455733,12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 23S ribosomal RNA 3cc7 0 2754 2.7 RF02540,RF00002 URS000080E214_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaauagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U; 23S ribosomal RNA 3cc7 9 122 2.7 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U; 5S ribosomal RNA 3cce 0 2754 2.75 RF02540,RF00002 URS000080DEE9_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccacgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A; 23S RIBOSOMAL RNA 3cce 9 122 2.75 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A; 5S RIBOSOMAL RNA 3ccj 0 2754 3.3 RF02540,RF00002 URS000080E310_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuacuucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<..[[.>>>>>>....<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>...........>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>......<<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>>......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((.(....).))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.((...(((.........)))...))........(..........)..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..((....))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).))......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((....(((...((((((((((}}..)))))...))))).[.)))..)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2534U; 23S RIBOSOMAL RNA 3ccl 0 2754 2.9 RF02540,RF00002 URS000080DD39_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccccgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535C. Density for Anisomycin is visible but not included in model.; 23S RIBOSOMAL RNA 3ccm 0 2754 2.55 RF02540,RF00002 URS000080E039_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucguuagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(...)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2611U; 23S RIBOSOMAL RNA 3ccq 0 2754 2.9 RF02540,RF00002 URS000080E20E_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacugagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488U; 23S RIBOSOMAL RNA 3ccr 0 2754 3.0 RF02540,RF00002 URS000080E07E_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaaccgagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....((..(((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..))).....)).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model.; 23S RIBOSOMAL RNA 3ccr 9 122 3.0 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model.; 5S RIBOSOMAL RNA 3ccs 0 2754 2.95 RF02540,RF00002 URS000080E271_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuaggaauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A; 23S RIBOSOMAL RNA 3ccs 9 122 2.95 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A; 5S RIBOSOMAL RNA 3ccu 0 2754 2.8 RF02540,RF00002 URS000080E353_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuaggcauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482C; 23S RIBOSOMAL RNA 3ccu 9 122 2.8 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482C; 5S RIBOSOMAL RNA 3ccv 0 2754 2.9 RF02540,RF00002 URS000080DE11_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcuaggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2616A; 23S RIBOSOMAL RNA 3cd6 0 2754 2.75 RF02540,RF00002 URS000080DE11_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcuaggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-cystal of large Ribosomal Subunit mutant G2616A with CC-Puromycin; 23S RIBOSOMAL RNA 3cd6 9 122 2.75 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-cystal of large Ribosomal Subunit mutant G2616A with CC-Puromycin; 5S RIBOSOMAL RNA 3cma 0 2754 2.8 RF02540,RF00002 URS000080E102_2238 18818369 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCA and CCA-Phe-Cap-Bio bound to the large ribosomal subunit of Haloarcula marismortui; 23S RIBOSOMAL RNA 3cme 0 2754 2.95 RF02540,RF00002 URS000080E102_2238 18818369 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((.{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The Structure of CA and CCA-PHE-CAP-BIO Bound to the Large Ribosomal Subunit of Haloarcula Marismortui; 50S RIBOSOMAL RNA 3cpw 0 2754 2.7 RF02540,RF00002 URS000080E267_2238 18494460 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccccgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<....<.<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>>..>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI; 23S RIBOSOMAL RNA 3e5c A 53 2.25 RF01767 URS000080DEC9_32630 18806797 2.5.1.6 0004478 0006446 32630 nuucccgaaaggauggcggaaacgccagaugccuuguaaccgaaagggggaau <<<<<<..<<<<.<<<<<....>>>>>....>>>>....<<....>>>>>>>> ((((((..((((.(((((....)))))....))))....((....)))))))) Crystal Structure of the SMK box (SAM-III) Riboswitch with SAM; SMK box (SAM-III) Riboswitch 3e5f A 53 2.7 RF01767 URS000080DEC9_32630 18806797 2.5.1.6 0004478 0006446 32630 nuucccgaaaggauggcggaaacgccagaugccuuguaaccgaaagggggaau <<<<<<..<<<<.<<<<<....>>>>>....>>>>....<<....>>>>>>>> ((((((..((((.(((((....)))))....))))....((....)))))))) Crystal Structures of the SMK box (SAM-III) Riboswitch with Se-SAM; SMK box (SAM-III) Riboswitch for RNA 3g4s 0 2754 3.2 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<..[[.>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(.(..(((.........)))...))........((........))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))..(((((((.....)))))))..(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((.(..((((.............))))...)))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Tiamulin bound to the large ribosomal subunit; 23S ribosomal RNA 3g6e 0 2754 2.7 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit; 23S ribosomal RNA 3g6e 9 122 2.7 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit; 5S ribosomal RNA 3g71 0 2754 2.85 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Bruceantin bound to the large ribosomal subunit; 23S ribosomal RNA 3g71 9 122 2.85 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Bruceantin bound to the large ribosomal subunit; 5S ribosomal RNA 3i55 0 2754 3.11 RF02540,RF00002 URS000080E102_272569 19738021 0003735 0005840 272569 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>>....<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>...........>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((...{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}...)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit; 23S ribosomal RNA 3i56 0 2754 2.9 RF02540,RF00002 URS000080DF02_272569 19738021 0003735 0005840 272569 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit; 23S ribosomal RNA 3i56 9 122 2.9 RF00001 URS00000A7E81_2238 19738021 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit; 5S ribosomal RNA 3ow2 0 2754 2.7 RF02540,RF00002 URS000080DF99_2238 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(...)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit; 23S RIBOSOMAL RNA 4lck B 75 3.2 RF00005 URS000080DE51_182710 23892783 0030533 0006412 182710 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; tRNA-Gly 4lck C 102 3.2 RF00230 URS000080DF58_182710 23892783 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((((((..(((((((......[..((((((..........])))))).))))))))))))).......))))..)))))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; T-BOX RIBOSWITCH STEM I 4lck E 75 3.2 RF00005 URS000080DE51_182710 23892783 0030533 0006412 182710 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; tRNA-Gly 4lck F 102 3.2 RF00230 URS000080DF58_182710 23892783 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((.(((..(((((((......[..((((((..........])))))).)))))))))).)).......))))..)))))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; T-BOX RIBOSWITCH STEM I 4msr B 10 1.2 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with six 2'-5'-linkages; RNA 10mer duplex with six 2'-5'-linkages 4o41 A 11 1.2 URS000080DE24_32630 24813446 32630 gagcncggcuc ........... ........... Amide linked RNA; AMIDE LINKED RNA 4tzw B 75 4.671 RF00005 URS000080DE51_1423 25185828,23892783 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and replacing Mg2+ with Sr2+ post crystallization; engineered tRNA 4tzw C 102 4.671 RF00230 URS000080DF58_221109 25185828,23892783 0000049 221109 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((((((..(((((((......[..((((((..........])))))).))))))))))))).......))))..)))))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and replacing Mg2+ with Sr2+ post crystallization; T-box Stem I 4tzy X 71 2.57 RF00167 URS000080E2A9_672 25185828 0009113 672 gggaagauauaauccuaaugauaugguuugggaguuucuaccaagagccuuaaacucuugauuaucuuccc <<<<<<<<<...<<<<<<......<<.>>>>>>........<<<<<<>>.....>>>>>>..>>>>>>>>> ((((((((((..((((((......[[.))))))[.....)]((((((]].....))))))..))))))))) Vibrio vulnificus Adenine Riboswitch Variant, grown in both Sr2+ and Mg2+; Vibrio vulnificus Adenine Riboswitch 4y1j A 100 2.24 URS00008116BC_1360 25794619 1360 aaaggggaguagcgucgggaaaccgaaacaaagucgucuauucgugaggaaacucaccggcuuuguugacauacgaaaguauguuuagcaagaccuuucc <<<<<......<<.<<<<....>>>><<<<<<<<<........<<<<<....>>>>>.>>>>>>>>><<<<<<<....>>>>>>>..>>....>>>>>.. (((((......((.((((....))))((((((((((.......(((((....)))))))))))))))(((((((....)))))))..))....))))).. Lactococcus lactis yybP-ykoY Mn riboswitch A41U binding site mutant in presence of Mn2+; yybP-ykoY riboswitch 4y1j B 100 2.24 URS00008116BC_1360 25794619 1360 aaaggggaguagcgucgggaaaccgaaacaaagucgucuauucgugaggaaacucaccggcuuuguugacauacgaaaguauguuuagcaagaccuuucc <<<<<......<<.<<<<....>>>><<<<<<<<<........<<<<<....>>>>>.>>>>>>>>><<<<<<<....>>>>>>>..>>....>>>>>.. (((((......((.((((....))))((((((((((.......(((((....)))))))))))))))(((((((....)))))))..))....))))).. Lactococcus lactis yybP-ykoY Mn riboswitch A41U binding site mutant in presence of Mn2+; yybP-ykoY riboswitch 4y1m B 107 3.0 RF00080 URS00008116AD_562 25794619 0030145 562 gauuuggggaguagccgauuuccgaaaggaaauguacgugucaacauuuucguugaaaaacguggcacguacggacugaagaaauucagucaggcgagaccauaucc <<<.<<<......<<<.<<<<<<....>>>>>><<<<<<<<<........<<<<....>>>>.>>>>>>>>>.<<<<<<<....>>>>>>>.>>>....>>>.>>>. (((.(((......(((.((((((....))))))((((((((((.......((((....)))))))))))))).(((((((....))))))).)))....))).))). An Escherichia coli yybP-ykoY Mn riboswitch in the Mn2+-free state; E. coli yybP-ykoY riboswitch 4y1m A 76 3.0 URS00008116AD_562 25794619 562 gauuuggggaguagccgauuuguacgugucaacauuuucguugaaaaacguggcacguacaggcgagaccauaucc <<<.<<<......<<<......<<<<<<<<........<<<......>>>.>>>>>>>>..>>>....>>>.>>>. ((..(((......(((........(((((((.......(((......))))))))))....)))....)))..)). An Escherichia coli yybP-ykoY Mn riboswitch in the Mn2+-free state; E. coli yybP-ykoY riboswitch 5t83 A 90 2.71 RF00442 URS0000B21DF2_679936 28017522 0010468 679936 aaguuugcuaggguuccgcgucauagguggucugguccaagagcaaacggcuuucacaaagccacacggaaggauaaaagccugggagau ..<<<<<<..<<...<<<<<<.....>>>...>>>.>>....>>>>>><<<<<.....>>>>>...<...<<<.......>>>....>.. ..((((((..((...(((((((...))))..).)).))....))))))((((.......)))).[.(....((.......))..]..).. Structure of a guanidine-I riboswitch from S. acidophilus; RNA (95-MER) 5v1l C 12 1.2 URS0000BC466D_32630 28570818 32630 cgcgaaunagcg ............ ............ Structure of S-GNA dodecamer; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3') 6n2v A 99 2.85 RF00080 URS000197CF63_347 31541094 0030145 347 ngcuuggggaguagccugcuuucggaaacgaaagcgccuguaucaacauacucggcgaaagccguggugcaggaccgaaaggucuggcgagaccaggcc <<<<<<<......<<<.<<<<<<<....>>>>>>>.<<<<<<<<........<<<<....>>>>.>>>>>>>><<<....>>>..>>>....>>>>>>> (((((((......(((.(((((((....))))))).(((((((((.......((((....)))))))))))))(((....)))..)))....))))))) Manganese riboswitch from Xanthmonas oryzae bound to Mn(II); X. oryzae Mn riboswitch optimized construct 6n2v B 99 2.85 RF00080 URS000197CF63_347 31541094 0030145 347 ngcuuggggaguagccugcuuucggaaacgaaagcgccuguaucaacauacucggcgaaagccguggugcaggaccgaaaggucuggcgagaccaggcc <<<<<<<......<<<.<<<<<<<....>>>>>>>.<<<<<<<<........<<<<....>>>>.>>>>>>>><<<....>>>..>>>....>>>>>>> (((((((......(((.(((((((....))))))).(((((((((.......((((....))))))))))))).((....))...)))....))))))) Manganese riboswitch from Xanthmonas oryzae bound to Mn(II); X. oryzae Mn riboswitch optimized construct 7ei5 A 35 2.9 32630 cagcaggcuaaggcaugaaagtgctatgcctgctg <<<<<<<<....<<<<....>>>>...>>>>>>>> ((((((((...(((((....)))))..)))))))) GNRA tetraloop receptor motif composed of RNA and DNA; DNA/RNA (35-MER) 7jnh A 25 2.89 URS00021ED909_32630 33414189 32630 aaaaaaaaaaaaaaaaaaaaaaaaa ......................... ......................... Crystal structure of a double-ENE RNA stability element in complex with a 28-mer poly(A) RNA; 28-mer poly(A) RNA 7mlw F 125 2.7 RF00442 URS00023119BD_987057 34257148 0010468 987057 ggaucgcuaggguuccggucgugcggcgucgccgcacgaugcugguccgagagcaauccggucuugccuucgccucguucgcgaggaaacggcgaggcuccacggagggauaaaagcccgggagg <<<<.<<..<<...<<<<<<<<<<<<<<.>>>>>>>>>>>..>>>.>>....>>.>>>>.....<<<<.<..<<<<<....>>>>>..>.>>>>........<...<<<.......>>>....>. ((((.((..((...((((((((((((((.))))))))))).).)).))....)).))))((..(((((.(..(((((....)))))..).)))))..)).(.[...(((.......))).)..]. Burkholderia sp. TJI49 Guanidine-I riboswitch; Guanidine-I riboswitch 7uz0 A 87 3.03 RF00005 URS00023359B3_1462 0030533 0006412 1462 ncggaaguaguucagugguagaacaccuacuggcccgaaaggguggaaccccaguagggggucgcggguucgagucccgucuuccgc <<<<<<<..<<<<.......>>>>.<<<<<<<<<<<....>>>.......>>>>>>>>.....<<<<<.......>>>>>>>>>>>> (((((((..((((....[..)))).(((((((((((....))).......)))))))).....(((((..]....)))))))))))) AntiT-tRNA flip UCCA; AntiT-tRNA flip UCCA 8k30 B 51 2.43 RF01684 8090 gacgccgguggggcacuccuggcaggacgggguucaauucccugcgguguc <<<<<<<<<<...>>><<<<<.>>>>><<<<<.......>>>>>>>>>>>> ((((((((((..[)))(((((.)))))(((((..]....)))))))))))) Crystal structure of a medaka mascRNA U23G; RNA (56-MER)