4v9b AA 1506 3.1 RF00177,RF01959,RF01960 URS000080DEDF_300852 23431179 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<.............>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((.............)))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(...(((.....))).)....).)))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of the 70S ribosome with tigecycline.; 16S ribosomal RNA 4v9b CA 1506 3.1 RF00177,RF01959,RF01960 URS000080DEDF_300852 23431179 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<...<<<<<<....>>>>>>..<.<<<......>>>.>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((..(((..(((((((....)))))))...((((....))))..)))..)))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((.......(((.....)))......)).))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of the 70S ribosome with tigecycline.; 16S ribosomal RNA 4yhh A 1507 3.417 RF00177,RF01959,RF01960 URS00008116AF_300852 25753625 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<..<....<<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.(..(((((((.....)))))))..).)))))......(((......((((((((..((...(((((((.((((.....((((.(....).))))......))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((....((........))..)))).)).))))))..((((......((((....)))).....))))....(((.(...(....((((.....)))).....)....).)))......((((([[[...(((((.....((.]]])).......))))))))))..))))))))).............[[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((....(((((((....((((((....((........)).......))))))....).......((....)).))))))...))))).)))...)))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))....(((......((((....))))....)))...]]].]((..(.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.((((......((..(((.....))))).......))))..(..(((((....))))).....)..)))).....).)..))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...))))))))...))..(.(..((.(.(.((.(((..(((((((((((((...(..(((....(((....))).)))..)..)))))))))))))..))).)).)..).))...)..)..((((((((......))))))))}... Crystal structure of the 30S ribosomal subunit from Thermus thermophilus in complex with tigecycline; 16S ribosomal RNA 5j8a AA 1534 3.1 RF00177,RF01959,RF01960 URS0000A7637F_562 27382179 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 16S rRNA 5j8a BA 1533 3.1 RF00177,RF01959,RF01960 URS0000A7637F_562 27382179 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 16S rRNA 5j91 AA 1534 2.96 RF00177,RF01959,RF01960 URS000081169C_562 27382179 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(........)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 16S rRNA 5j91 BA 1533 2.96 RF00177,RF01959,RF01960 URS000081169C_562 27382179 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(........)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 16S rRNA 6ysi 1 2672 2.5 RF02540,RF02541 URS0000211949_575584 32857965 0003735 0005840 575584 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuuuguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcaagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugaaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugaagaugcaguguacccgcggcuagacggaaagaccccgugaaccuuuacugcagcuugacacugaacugguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucuggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucucauccuggggcugaagcaggucccaaggguauggcuguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu 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(((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((((((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((....(((((((((.....(((...(((.((((....)))).)))..)).).....)))))).)))...)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...({((((((...........((..(((((..(((..)))..))))).))...........]]].....}))))))))))...)))))))(((((((.....)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))....(((....((((.(((((((.((.....)))))))))....))))....))).....)))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((......))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((...(((((..(((((.(((.(((((.((((..))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(..((((.........))))....).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)..)))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit; 23S ribosomal RNA 6ysi 5 115 2.5 RF00001 URS0000143D25_575584 32857965 0003735 0005840 575584 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<<.............>>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit; 5S ribosomal RNA 6ytf 3 453 3.0 RF00177,RF01959,RF01960 URS00007DA5A6_575584 32857965 0003735 0005840 575584 gggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuccagagauggauuggugaaucuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucauggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccggg ...<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>......>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>> ...((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((....(..((((....))))..).......))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))) Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit head; 16S ribosomal RNA 8k2a L1 1500 2.9 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>...............<<.....>>..........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. 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Cryo-EM structure of the human 55S mitoribosome with Tigecycline; 16S rRNA 8k2a S1 928 2.9 RF00177 URS00021ED90F_9606 38942792 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))......(((((((.....))))))).......)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the human 55S mitoribosome with Tigecycline; 12S rRNA 8k2b L1 1500 3.4 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>...............<<.....>>..........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<<<<<<<<...<<.......>>...>>>>>>>..>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 39S mitoribosome with Tigecycline; 16s rRNA 8k2c L5 3771 2.4 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<..<<<<......<<<<<<<<..>>>>>>>>.......>>>>..>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<.................................<........................>.............................................>...>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.((((.(..............).))))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((((((...............................................................................................................)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((......(((.(((((((......)))))))))).....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline; 28S rRNA 8k2c S2 1740 2.4 RF01960,RF02542,RF01959,RF00177 URS00021ED8E3_9606 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..))))).))))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).((.(......)))....))......).)))..)))........(.((.(.(((((...............))))).).)).)....)....(((..((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(.....................)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with Tigecycline; 18S rRNA 8k2d C1 3188 3.2 RF02543 38942792 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<....>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(((.(...))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((.((((((..........(((((..((....))............))))).))))))..))))))))))...(((((.....((((..(((.(......).)))..........]]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A; 23S rRNA 8k82 C2 1771 3.0 RF01960,RF02542,RF01959,RF00177 38942792 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((.{((.<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<....................>>>>>>...<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....((((((....................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...(((((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>....... Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA; 18S rRNA 8k82 C1 3204 3.0 RF02543 38942792 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<.<<.<..........<<<<......................>>>>..>>>.>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((.(.(((....(.........)....))).....(...((......)).)..))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((.(.....)..)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((.(....(.((..........(..(..(.(...))............)..)..))).....).))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA; 23S rRNA 8xsx L5 3771 2.4 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<..<<<<......<<<<<<<<..>>>>>>>>.......>>>>..>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<.<<.............>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<......<<...<.<<<<....>>>>.>...>>...>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<.................................<........................>.............................................>...>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((...(....((((.(((..((.(..).))))))))))...))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.((((.(..............).))))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((.((((...............................................................................................................)).)).)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.....}.......))))....)))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((......(((.(((((((......)))))))))).....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2; 28S rRNA 8xsy L5 3771 3.0 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<.................................<........................>.............................................>...>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.(((..((.(..).)))))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.((((.(..............).))))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[.[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]].]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((((((...............................................................................................................)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((......(((.(((((((......)))))))))).....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled); 28S rRNA 8xsz L5 3668 3.2 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagaucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<.....>.>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.(((..((.(..).)))))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.(((..(..............)..)))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((............((((....)))).........))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((((((..(.)...)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; 28S rRNA 8xt0 L1 1500 3.2 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>...............<<.....>>..........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline; 16s rRNA 8xt0 S1 928 3.2 RF00177 URS00021ED90F_9606 38942792 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((.(((.(....((..(((((.....))).......))..)).....(((....))).....).).))....)).)))).)...)))))))..)).)))))))).(...((((.....))))......(((((((.....))))))).......)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline; 12s rRNA 8xt1 L1 1500 3.1 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>.....>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....))))..(.((((((((((.....((......)).....))))))))))..)...((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline; 16s rRNA 8xt2 L1 1500 3.3 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>...............<<.....>>..........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline; 16s rRNA 8xt2 S1 928 3.3 RF00177 URS00021ED90F_9606 38942792 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))).)...)))))))..)).)))))))).(...((((.....))))......(((((((.....))))))).......)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline; 12s rRNA 8xt3 L1 1500 3.1 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>.....>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline; 16s rRNA 8yoo L5 3670 2.0 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<.<<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>.>>>>.>>>>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.............>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<.<....>.>.>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((((((.(((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((...(....((((.((...((.(..).)).)))))))...))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((((())))))))).......))))).))))........))))))..)))))))))))......{.............((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((((((((((((((..(((....)))..)))))).)))).)))))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(((...............)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((...........)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((...((.....((((.(((((((......)))))))))))....))...)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline; 28S rRNA 8yoo S2 1719 2.0 RF01960,RF02542,RF01959,RF00177 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuggcucucggcgcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<......<<.<........>.>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..))))).))))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(......((............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.((((.................)))).).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(.....................)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline; 18S rRNA