6xqd 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 16S Ribosomal RNA 6xqd 2a 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 16S Ribosomal RNA 6xqe 1a 1500 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...((((((..(((((.....((((......))))......)))))....(((..(((((....)))))..)))...(((.....)))..))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 16S Ribosomal RNA 6xqe 2a 1503 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((....))))))))).)))))......(((......((((((((..((...(((((((.(((((....((.(((....))).)).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((((...(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).))))).....))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 16S Ribosomal RNA 8crx A 1505 2.78 RF00177,RF01959,RF02542,RF01960 URS0000A1FB0E_1747 36864821 0003735 0005840 1747 cauuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuggggugcucgaguggcgaacgggugaguaacacgugaguaaccugcccuugacuuugggauaacuucaggaaacuggggcuaauaccggauaggagcuccugcugcaugguggggguuggaaaguuucggcgguuggggauggacucgcggcuuaucagcuuguuggugggguaguggcuuaccaaggcuuugacggguagccggccugagagggugaccggccacauugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcggaagccugaugcagcaacgccgcgugcgggaugacggccuucggguuguaaaccgcuuucgccugugacgaagcgugagugacgguaauggguaaagaagcaccggcuaacuacgugccagcagccncggugauacguagggugcgagcguuguccggauuuauugggcguaaagggcucguaggugguugaucgcgucggaaguguaaucuuggggcuuaacccugagcgugcuuucgauacggguugacuugaggaagguaggggagaauggaauuccugguggagcgguggaaugcgcagauaucaggaggaacaccaguggcgaaggcgguucucugggccuuuccugacgcugaggagcgaaagcguggggagcgaacaggcuuagauacccugguaguccacgcuguaaacgguggguacuaggugugggguccauuccacggguuccgugccguagcuaacgcuuuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacggggccccgcacaagcggcggagcaugcggauuaauucgaunnaacgcguagaaccuuaccuggguuugacauggaucgggagugcucagagaugggugugccucuuggucgguucacagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuguucacuguugccagcacguuaugguggggacucaguggagaccgccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacgcaugcuacaauggcugguacagagaguggcgagccugugagggugagcgaaucucggaaagccggucucaguucggauuggggucugcaacucgaccucaugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccggggcuuguacacacngncngunaagucaugaaaguugguaacacccgaagccgguggccuaaccguugugggggagccgucgaaggugggacuggugauuaggacuaagucgnaacaagguagccguaccngnnggugcggcuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<.<<<..>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<......<<....>>.......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<.<...>.>>>>>>>>>>>>..<<<..))>>>....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<....<<<<<<....>>>>>>...........>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<......>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<......>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(.(((..)))...)))..)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....((((((((((....)))))))))).....(......).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((((((((...(...(....)...)....))))))...)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.(...).))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((.(...(((((((....))))))).(.....).).).).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((......)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(......).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound; RNA (1537-MER) 8crx a 2903 2.78 RF02541 URS000268139D_1747 36864821 0003735 0005840 1747 caaaguuguguagugcgaucgguggaugccuuggcaccaagagccgaugaaggacguugugaccugcgauaagcccuggggaguuggugagcgagcugugauccggggguguccgaauggggaaaccuggaauguccggaguaguguccgguggcccugcccugaauguauaggggugugggugguaacgcggggaagugaaacaucuuaguacccguaggaagagaaaacaagugugauuccgugaguaguggcgagcgaaagcggaggaggcuaaaccgugugugugucagguguugcaugugcgggguugugggggccuugugguucugcugccgcaggauuggccagugagaaauguugcgugaaggugaagcgucugggaaggcguaccggagugggugagaguccuguaacuguaagcguggcacuggugugggguugccccgaguagcgugggacucguggaauuucgcgugaaucuggcgggaccacccgucaagccuaaauacuccuuggugaccgauaguggaugaguaccgugagggaagggugaaaaguaccccgggaggggagugaaagaguuccugaaaccggucgcaugcaagccgucagagccuguguggugauggcgugccuuuugaagaaugagccugcgaguuagugaugcguggcgagguuaacccguggugggggagucguagcgaaagcgaguccgauaagggcgugagucgcguguucuagacccgaagcggugugaucuauccauggccaggaugaagcgucgguaagacgucguggagguccgaacccacuucaguugaaaauggaggggaugaguuguggauaggggugaaaggccaaucaaacaccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucuuguuggagguagagcacuggauggucuagggggcuuaucggcuuaccgaaaucagccaaacuccgaaugcuggcaaguguagcguggcagugagacggcgggugauaagcuucgucgucgagagggaaacagcccagaucaucagcuaaggccccuaaguggugacucagugggaaaggauguggaguugcguagacaaccaggagguuggcuuggaagcagccauccuugaaagagugcguaauagcucacuggucaagugauuccgcgccgauaauguagcggggcuuaaguuauccgccgaagcuguggcaaccugugugguuggguaggggagcgucgugucaguggugaagcugccgggugacugugugguggaguugaugcgagugagaaugcaggcaugaguagcgugugacgggugggaaucccguccgccgauuauccaaggguuccagggucaaguuugucugcccugggugagucggguccuaaggcgaggccgacaggcguagucgauggguaaccaguugauauucugguaccggcuugucaccgcaagcugcggagggacgcagugagguagcucauccccggugaugguuguccggggcuaaguguguggacugucugguagguaaauccgcugggcgugaagguugaggcaugauggggagcccaugguugugggugagugagugauccuguacugucgagaaaagcuucgugagcgagguggcggguccgcccguacccuaaaccgacacugguggauagguagaguauaccgaggcgaucgagugaaucguggugaaggaacucggcaaaaugcccccguaacuuugggauaagggggaccugagcugucgugcacccgugcggugugguggcggugaggggcgcagaguccagggggaaacgacuguuuaccaaaaacacagguccgugcgaagucguaagacgauguauacggacugacuccuncccggugcuggaagguuaaggggaacugugaguguaugcguagcggugaacuuaagccccaguaaacggcggugguaacnauaaccauccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggaguaacgauuucccuacugucuccaccaugaacucggugaaauugcauuacgaguaaagaugcucguuacgcgcagcaggacggaaagaccccgggaccuuuacuauaguuugguauuggugauugggacgguuuucugauuguucugguuaucucacuguggaccgugauccgguucaaggacagugccugauggguaguuugacugnggcggucgccuccuaaaggguaacggaggcgcccaaagguucccucagccugguugguaaucagguggugaguguaagugcacaagggggcuugacugugagacugacaggucgagcagggacgaaagucgggacuagugaucugacgguggcuuguggaugcgccgucacucaacggauaaaagguaccccgngganaacaggcugaucuugcccgagcgcucauagcgacggcaugguuuggcancucgnugucggcucgucgcauccuggggcuggagucggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgcugcgcgcggaggaaucuugagaagggcugucuuuaguacgagaggaccgagacggacugaccucuggugugccaguuguucugccaagagcauggcugguuggcuacgucggguugugauaaccgcugaaagcaucuaagcgggaagcacgcuucaagauaaggguucccacaggaguguuccugguaagguccccgagagaugaucggguugauaggccagacguggacgcaucguaagguguggagcugacugguacuaauagaccgaggacuuuca ..<<<.......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<...<<)))....>>.......>>>>>>>...>>>....<<<....>>>.......<<<<<......>>>>>..<<<<.<<<<<.........>>>>>..>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<......................>>>>......<<<<<<<<<......<<<<....>>>>..................<<...<....<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.......>...>>......>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>.......<<<<..<<<<>>>>...>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.....>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<......>>.>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<...<<<.........>>>...>>.........<<......>>....>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<.....>>>>>....>>>>>>..<<<<<<<<<.......<<<<<<<<....>>>.>>>>>....>>>>>>>>>........>>>>>>.......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<.<<..<..<....<<<<<<<<<....<<<<..<<<..<<<<<.<<<<<<...((((...>>>>>><<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>....<<.........>>.....>>>>>...>>>...>>>>.........>>>>>>.>>>...>..>..>>.>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>>.<<<..<<<<<<<..................>>>>>>>..>>>.............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<..<<<...<<<<<..<<....>>...>>>>>...>>>..>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.......((..<<<<<......))>>>>>..<<<<<<<<.(((.[[......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<..........>>>>>>>>>>>>>...<<.<<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<<..<<.......>>>..>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<<))))>>>>>>..>>>>>>..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<....>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>......>>>.. ..((........((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((......]]]..............))))))...)))....(((....))).(.....(((((......))))))..(((.(((((.........)))))..))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((........................)))....(.(((((((.(.......(((....)))...................((........(((...(((((......)))))[[(...).(((.....]])))...)))...........))......).)))..))))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.....)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((.((......)).)))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..((((((((((.....(((...(((.((((...((.(((......)))..))...)))).)))..)).).....)))))))).).)))))))).))..(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(.(.(..(((.........)))...)).....(....(......)..).).))....)))))))))).))...........]]].)....))))))))))...)))))))(((((.....)))))....))))))(.((((((.(((......((((((((....))).)))))...))).))))))..).....))))))(......((....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((.((..(..(....((.((((((....(((((.(((..(((.(.(((((((...{{{.).))))))((..((((...(((((((((((.((.....))))))))).....))))...))))...))....((.........)).....).)))...)))..)))))(..).....))))))..))...)..)..)).))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....))))).(((...(((((......(......)......)))))...))).(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.(((((((((.(...(......)...).)))))))))...((.(((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.(.((((...((.......))...)))).)...).)).).)......(.((.((((((..((((.((((......)))).)..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((......))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).......)).. Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound; 23S ribosomal RNA 8cvm a 2903 2.66 RF02541 URS000268139D_1747 36864821 0003735 0005840 1747 caaaguuguguagugcgaucgguggaugccuuggcaccaagagccgaugaaggacguugugaccugcgauaagcccuggggaguuggugagcgagcugugauccggggguguccgaauggggaaaccuggaauguccggaguaguguccgguggcccugcccugaauguauaggggugugggugguaacgcggggaagugaaacaucuuaguacccguaggaagagaaaacaagugugauuccgugaguaguggcgagcgaaagcggaggaggcuaaaccgugugugugucagguguugcaugugcgggguugugggggccuugugguucugcugccgcaggauuggccagugagaaauguugcgugaaggugaagcgucugggaaggcguaccggagugggugagaguccuguaacuguaagcguggcacuggugugggguugccccgaguagcgugggacucguggaauuucgcgugaaucuggcgggaccacccgucaagccuaaauacuccuuggugaccgauaguggaugaguaccgugagggaagggugaaaaguaccccgggaggggagugaaagaguuccugaaaccggucgcaugcaagccgucagagccuguguggugauggcgugccuuuugaagaaugagccugcgaguuagugaugcguggcgagguuaacccguggugggggagucguagcgaaagcgaguccgauaagggcgugagucgcguguucuagacccgaagcggugugaucuauccauggccaggaugaagcgucgguaagacgucguggagguccgaacccacuucaguugaaaauggaggggaugaguuguggauaggggugaaaggccaaucaaacaccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucuuguuggagguagagcacuggauggucuagggggcuuaucggcuuaccgaaaucagccaaacuccgaaugcuggcaaguguagcguggcagugagacggcgggugauaagcuucgucgucgagagggaaacagcccagaucaucagcuaaggccccuaaguggugacucagugggaaaggauguggaguugcguagacaaccaggagguuggcuuggaagcagccauccuugaaagagugcguaauagcucacuggucaagugauuccgcgccgauaauguagcggggcuuaaguuauccgccgaagcuguggcaaccugugugguuggguaggggagcgucgugucaguggugaagcugccgggugacugugugguggaguugaugcgagugagaaugcaggcaugaguagcgugugacgggugggaaucccguccgccgauuauccaaggguuccagggucaaguuugucugcccugggugagucggguccuaaggcgaggccgacaggcguagucgauggguaaccaguugauauucugguaccggcuugucaccgcaagcugcggagggacgcagugagguagcucauccccggugaugguuguccggggcuaaguguguggacugucugguagguaaauccgcugggcgugaagguugaggcaugauggggagcccaugguugugggugagugagugauccuguacugucgagaaaagcuucgugagcgagguggcggguccgcccguacccuaaaccgacacugguggauagguagaguauaccgaggcgaucgagugaaucguggugaaggaacucggcaaaaugcccccguaacuuugggauaagggggaccugagcugucgugcacccgugcggugugguggcggugaggggcgcagaguccagggggaaacgacuguuuaccaaaaacacagguccgugcgaagucguaagacgauguauacggacugacuccuncccggugcuggaagguuaaggggaacugugaguguaugcguagcggugaacuuaagccccaguaaacggcggugguaacnauaaccauccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggaguaacgauuucccuacugucuccaccaugaacucggugaaauugcauuacgaguaaagaugcucguuacgcgcagcaggacggaaagaccccgggaccuuuacuauaguuugguauuggugauugggacgguuuucugauuguucugguuaucucacuguggaccgugauccgguucaaggacagugccugauggguaguuugacugnggcggucgccuccuaaaggguaacggaggcgcccaaagguucccucagccugguugguaaucagguggugaguguaagugcacaagggggcuugacugugagacugacaggucgagcagggacgaaagucgggacuagugaucugacgguggcuuguggaugcgccgucacucaacggauaaaagguaccccgngganaacaggcugaucuugcccgagcgcucauagcgacggcaugguuuggcancucgnugucggcucgucgcauccuggggcuggagucggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgcugcgcgcggaggaaucuugagaagggcugucuuuaguacgagaggaccgagacggacugaccucuggugugccaguuguucugccaagagcauggcugguuggcuacgucggguugugauaaccgcugaaagcaucuaagcgggaagcacgcuucaagauaaggguucccacaggaguguuccugguaagguccccgagagaugaucggguugauaggccagacguggacgcaucguaagguguggagcugacugguacuaauagaccgaggacuuuca ..<<<.......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<...<<)))....>>.......>>>>>>>...>>>....<<<....>>>.......<<<<<......>>>>>..<<<<.<<<<<.........>>>>>..>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<......................>>>>......<<<<<<<<<......<<<<....>>>>..................<<...<....<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.......>...>>......>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>.......<<<<..<<<<>>>>...>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.....>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<......>>.>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<...<<<.........>>>...>>.........<<......>>....>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<.....>>>>>....>>>>>>..<<<<<<<<<.......<<<<<<<<....>>>.>>>>>....>>>>>>>>>........>>>>>>.......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<.<<..<..<....<<<<<<<<<....<<<<..<<<..<<<<<.<<<<<<...((((...>>>>>><<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>....<<.........>>.....>>>>>...>>>...>>>>.........>>>>>>.>>>...>..>..>>.>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>>.<<<..<<<<<<<..................>>>>>>>..>>>.............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<..<<<...<<<<<..<<....>>...>>>>>...>>>..>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.......((..<<<<<......))>>>>>..<<<<<<<<.(((.[[......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<..........>>>>>>>>>>>>>...<<.<<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<<..<<.......>>>..>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<<))))>>>>>>..>>>>>>..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<....>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>......>>>.. ..((........((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((......]]]..............))))))...)))....(((....))).(.....(((((......))))))..(((.(((((.........)))))..))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((........................)))....(.(((((((.(.......(((....)))...................((........(((...(((((......)))))[[(...).(((.....]])))...)))...........))......).)))..))))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.....)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((.((......)).)))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..((((((((((.....(((...(((.((((...((.(((......)))..))...)))).)))..)).).....)))))))).).)))))))).))..(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(.(.(..(((.........)))...)).....(....(......)..).).))....)))))))))).))...........]]].)....))))))))))...)))))))(((((.....)))))....))))))(.((((((.(((......((((((((....))).)))))...))).))))))..).....))))))(......((....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((.((..(..(....((.((((((....(((((.(((..(((.(.(((((((...{{{.).))))))((..((((...(((((((((((.((.....))))))))).....))))...))))...))....((.........)).....).)))...)))..)))))(..).....))))))..))...)..)..)).))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....))))).(((...(((((......(......)......)))))...))).(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.(((((((((.(...(......)...).)))))))))...((.(((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.(.((((...((.......))...)))).)...).)).).)......(.((.((((((..((((..(((......)))..)..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((......))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).......)).. Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map; 23S ribosomal RNA 8cvo A 471 2.95 RF00177,RF01959,RF01960,RF02542 URS0000A1FB0E_1747 36864821 0003735 0005840 1747 gacggggccccgcacaagcggcggagcaugcggauuaauucgaunnaacgcguagaaccuuaccuggguuugacauggaucgggagugcucagagaugggugugccucuuggucgguucacagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuguucacuguugccagcacguuaugguggggacucaguggagaccgccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacgcaugcuacaauggcugguacagagaguggcgagccugugagggugagcgaaucucggaaagccggucucaguucggauuggggucugcaacucgaccucaugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccggggcuugu .<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<....<<<<<<....>>>>>>...........>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<......>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>> .(((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((.(...(((((((....))))))).(.....).).).).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((......)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))) Cutibacterium acnes 30S ribosomal subunit with Sarecycline bound, head domain only in the local refined map; 16S ribosomal RNA