8ud6 1A 2871 2.7 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........))..))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud6 2A 2800 2.7 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.<......>.>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.....(............)......))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..((.......((((((((....))))))))....))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud7 1A 2871 2.55 RF02541 URS00001698E8_300852 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..(((..........))..))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud7 2A 2800 2.55 RF02541 URS00001698E8_300852 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((............).).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud8 1A 2871 2.6 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<..........>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((.(......).)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((.....))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud8 2A 2800 2.6 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..((............).).)..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(.(......((((((((....))))))))...).)............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA