8uvs 1a 1500 2.75 RF00177,RF01959,RF02542,RF01960 38165935 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 16S Ribosomal RNA 8uvs 2a 1503 2.75 RF00177,RF01959,RF02542,RF01960 38165935 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 16S Ribosomal RNA