Protein FDR Confidence: Combined	Accession	Description	Exp. q-value: Combined	Sum PEP Score	Coverage [%]	# Peptides	# PSMs	# Unique Peptides	# AAs	MW [kDa]	calc. pI	# Peptides (by Search Engine): A2 Sequest HT (293 IgG)	# Peptides (by Search Engine): B2 Sequest HT (293 Sel1L KO)	# Peptides (by Search Engine): C2 Sequest HT (293 WT)	# Peptides (by Search Engine): D2 Sequest HT (293 H KO)	# PSMs (by Search Engine): A2 Sequest HT (293 IgG)	# PSMs (by Search Engine): B2 Sequest HT (293 Sel1L KO)	# PSMs (by Search Engine): C2 Sequest HT (293 WT)	# PSMs (by Search Engine): D2 Sequest HT (293 H KO)	Abundance: F1: Sample, 293 IgG	Abundance: F2: Sample, 293 Sel1L KO	Abundance: F3: Sample, 293 WT	Abundance: F4: Sample, 293 H KO	Abundances Count: F1: Sample, 293 IgG	Abundances Count: F2: Sample, 293 Sel1L KO	Abundances Count: F3: Sample, 293 WT	Abundances Count: F4: Sample, 293 H KO	Modifications	Biological Process	Cellular Component	Molecular Function	Pfam IDs	Entrez Gene ID	Ensembl Gene ID	Gene Symbol	Chromosome	Reactome Pathways	KEGG Pathways	# Razor Peptides
Medium	P51617	Interleukin-1 receptor-associated kinase 1 OS=Homo sapiens OX=9606 GN=IRAK1 PE=1 SV=2	0.022	1.592	3	1	1	1	712	76.5	6.62				1				1										cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;nucleotide binding;protein binding;signal transducer activity	"Pf00069, Pf00531, Pf07714"	3654	ENSG00000184216.13	IRAK1	X	"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; activated TAK1 mediates p38 MAPK activation; NF-kB is activated and signals survival; Signalling by NGF; p75NTR recruits signalling complexes"	Chagas disease (American trypanosomiasis); Epstein-Barr virus infection; Neurotrophin signaling pathway; Leishmaniasis; NF-kappa B signaling pathway; Tuberculosis; Pertussis; Toxoplasmosis; Measles; Toll-like receptor signaling pathway	0

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