Protein FDR Confidence: Combined Accession Description Exp. q-value: Combined Sum PEP Score Coverage [%] # Peptides # PSMs # Unique Peptides # AAs MW [kDa] calc. pI # Peptides (by Search Engine): A2 Sequest HT (293 IgG) # Peptides (by Search Engine): B2 Sequest HT (293 Sel1L KO) # Peptides (by Search Engine): C2 Sequest HT (293 WT) # Peptides (by Search Engine): D2 Sequest HT (293 H KO) # PSMs (by Search Engine): A2 Sequest HT (293 IgG) # PSMs (by Search Engine): B2 Sequest HT (293 Sel1L KO) # PSMs (by Search Engine): C2 Sequest HT (293 WT) # PSMs (by Search Engine): D2 Sequest HT (293 H KO) "Abundance: F1: Sample, 293 IgG" "Abundance: F2: Sample, 293 Sel1L KO" "Abundance: F3: Sample, 293 WT" "Abundance: F4: Sample, 293 H KO" "Abundances Count: F1: Sample, 293 IgG" "Abundances Count: F2: Sample, 293 Sel1L KO" "Abundances Count: F3: Sample, 293 WT" "Abundances Count: F4: Sample, 293 H KO" Modifications Biological Process Cellular Component Molecular Function Pfam IDs Entrez Gene ID Ensembl Gene ID Gene Symbol Chromosome Reactome Pathways KEGG Pathways # Razor Peptides High P14625 Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1 0 688.749 70 75 765 73 803 92.4 4.84 5 48 74 6 126 633 99595307.13 268514260.8 1075153716 11986250950 27 32 67 104 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 7184 ENSG00000166598.14 HSP90B1 12 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); ATF6 (ATF6-alpha) activates chaperone genes; Interleukin-4 and 13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Estrogen signaling pathway; PI3K-Akt signaling pathway 4 High P04264 "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" 0 428.228 73 52 674 47 644 66 8.12 46 35 39 43 229 89 179 177 1871702062 1366538049 2794177817 1893517973 62 52 62 62 cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;extracellular;membrane;nucleus catalytic activity;motor activity;protein binding;receptor activity;structural molecule activity "Pf00038, Pf01576, Pf05103, Pf05957, Pf12128, Pf13166, Pf13514" 3848 ENSG00000167768.4 KRT1 12 Formation of the cornified envelope; Neutrophil degranulation 6 High Q9UBV2 Protein sel-1 homolog 1 OS=Homo sapiens OX=9606 GN=SEL1L PE=1 SV=3 0 611.669 70 40 642 40 794 88.7 5.39 1 39 38 4 260 378 10140270.91 69049353.31 4590439783 6164092220 10 18 58 69 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane protein binding "Pf00040, Pf08238" 6400 ENSG00000071537.13 SEL1L 14 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; Pre-NOTCH Processing in Golgi; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High Q13438 Protein OS-9 OS=Homo sapiens OX=9606 GN=OS9 PE=1 SV=1 0 662.333 76 61 585 61 667 75.5 4.87 49 60 199 386 14335114.02 534497879.3 2824194119 6531248682 9 25 72 82 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane;organelle lumen protein binding Pf07915 10956 ENSG00000135506.15 OS9 12 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High P52272 Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3 0 662.389 85 60 534 60 730 77.5 8.7 22 60 32 24 35 400 62 37 121678075.5 12643044702 551054584.4 377093233.6 38 92 50 50 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf11532, Pf11608, Pf13893, Pf14259" 4670 ENSG00000099783.11 HNRNPM 19 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 0 High P11021 Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2 0 467.67 63 52 460 50 654 72.3 5.16 24 40 26 51 46 117 54 243 81295504.2 1557071641 379020172.6 3487612603 33 48 43 61 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00012, Pf01968, Pf06723" 3309 ENSG00000044574.7 HSPA5 9 "Platelet degranulation ; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response; IRE1alpha activates chaperones" Prion diseases; Protein export; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Antigen processing and presentation 2 High O75592 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4 0 701.141 40 154 456 154 4678 513.3 7.02 1 33 105 135 1 36 189 230 29037699.78 172576601.7 634853886.4 549684420.3 28 60 133 151 0 High P35527 "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" 0 457.695 83 37 445 36 623 62 5.24 33 26 34 35 139 53 131 122 728012791.2 1159147206 1376759389 681421166.9 46 36 49 52 cell death;cell organization and biogenesis cytosol;membrane;nucleus structural molecule activity "Pf00038, Pf13166" 3857 ENSG00000171403.9 KRT9 17 Formation of the cornified envelope 0 High P13645 "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" 0 363.303 63 39 442 32 584 58.8 5.21 35 24 34 33 157 56 104 125 1226974151 545172548.3 2192019248 2736860655 50 37 48 52 cell death;cell differentiation;metabolic process cytoplasm;cytoskeleton;cytosol;membrane;nucleus structural molecule activity "Pf00038, Pf04111" 3858 ENSG00000186395.7 KRT10 17 Formation of the cornified envelope Staphylococcus aureus infection 12 High P39023 60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2 0 479.876 66 37 434 34 403 46.1 10.18 13 37 20 18 20 330 53 31 88146010.77 12521567387 279205327.6 99510373.33 23 58 32 38 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00297 6122 ENSG00000100316.15 RPL3 22 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 3 High Q96PY6 Serine/threonine-protein kinase Nek1 OS=Homo sapiens OX=9606 GN=NEK1 PE=1 SV=2 0 493.429 59 65 426 65 1258 142.7 5.94 43 54 57 82 166 178 10423936.99 492644566.4 1379876987 1398747433 18 48 66 74 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 4750 ENSG00000137601.16 NEK1 4 0 High P36578 60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5 0 490.12 71 45 400 45 427 47.7 11.06 10 44 24 16 19 285 62 34 30846771.24 15705862554 304647923.5 120138027.4 22 59 32 39 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00573, Pf14374" 6124 ENSG00000174444.14 RPL4 15 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9NR30 Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5 0 704.097 71 69 392 67 783 87.3 9.28 11 69 25 21 21 295 47 29 267648520.5 6287551946 183580776.6 76364362.57 23 77 40 47 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08152, Pf14617" 9188 ENSG00000165732.12 DDX21 10 Major pathway of rRNA processing in the nucleolus and cytosol; B-WICH complex positively regulates rRNA expression 3 High P35908 "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" 0 341.334 82 49 388 39 639 65.4 8 42 18 34 38 141 31 99 117 683074555.6 721736134.5 755073590.7 612247450.6 45 29 41 47 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process cytoskeleton;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf08614, Pf12128, Pf13166" 3849 ENSG00000172867.3 KRT2 12 Formation of the cornified envelope 8 High Q96DZ1 Endoplasmic reticulum lectin 1 OS=Homo sapiens OX=9606 GN=ERLEC1 PE=1 SV=1 0 420.516 87 39 380 39 483 54.8 6.28 37 39 184 196 2415121.51 30631679.57 3077394095 2656509367 10 13 47 51 metabolic process;transport endoplasmic reticulum;organelle lumen protein binding "Pf07915, Pf13015" 27248 ENSG00000068912.13 ERLEC1 2 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High P27694 Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2 0 450.204 72 41 378 41 616 68.1 7.21 3 27 39 36 4 79 165 130 36943017.84 933746092.8 1983976856 1540967480 14 39 52 50 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding;protein binding "Pf01336, Pf01485, Pf04057, Pf08646" 6117 ENSG00000132383.11 RPA1 17 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand; SUMOylation of DNA damage response and repair proteins Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High P19338 Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3 0 397.097 57 57 365 57 710 76.6 4.7 13 57 20 20 17 284 36 28 343097972.4 12593778918 270266106.3 99034375.21 21 66 32 35 regulation of biological process;response to stimulus cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 4691 ENSG00000115053.15 NCL 2 Major pathway of rRNA processing in the nucleolus and cytosol Pathogenic Escherichia coli infection 0 High P62424 60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2 0 355.48 64 29 338 29 266 30 10.61 15 29 17 18 32 222 52 32 59437202.96 12103493557 346896191.5 122113960.6 22 41 25 25 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01248 6130 ENSG00000280858.2; ENSG00000148303.16 RPL7A 9; CHR_HG2030_PATCH Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P61247 40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2 0 277.879 75 31 335 31 264 29.9 9.73 8 31 15 12 14 266 36 19 33124737.91 13183130368 162048000.6 126792108.1 19 43 22 21 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01015 6189 ENSG00000145425.9 RPS3A 4 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q08211 ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4 0 658.737 66 70 318 70 1270 140.9 6.84 8 68 30 18 11 237 46 24 41564908.63 4556679121 137758258.5 101854547 25 78 46 48 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717" 1660 ENSG00000135829.16 DHX9 1 TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; mRNA Splicing - Major Pathway; DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0 High P62917 60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2 0 437.198 70 20 301 20 257 28 11.03 8 20 12 8 18 248 22 13 29930263.61 9095274926 125748658.8 41575142.44 14 32 20 17 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity "Pf00181, Pf03947" 6132 ENSG00000161016.17 RPL8 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P06748 Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2 0 472.571 90 29 289 29 294 32.6 4.78 5 29 13 11 7 212 35 35 22355509.33 11918950813 293146083.1 100492309.2 12 37 19 21 Acetyl [N-Term] cell growth;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;enzyme regulator activity;protein binding;RNA binding Pf03066 4869 ENSG00000181163.13 NPM1 5 Nuclear import of Rev protein; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deposition of new CENPA-containing nucleosomes at the centromere 0 High P62701 "40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" 0 226.331 73 26 288 26 263 29.6 10.15 16 26 16 16 30 194 39 25 64342201.62 12838107779 278972325.1 125827208.5 17 35 23 24 cell organization and biogenesis;development;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00900, Pf08071" 6191 ENSG00000198034.10 RPS4X X "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q02878 60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3 0 232.035 63 29 285 29 288 32.7 10.58 11 29 18 15 19 188 44 34 132915720.6 14199183167 344061900.1 137195143.4 16 33 21 24 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf01159, Pf03868" 6128 ENSG00000089009.15 RPL6 12 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q00839 Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6 0 422.116 58 53 274 52 825 90.5 6 11 52 24 19 17 172 51 34 27889421.97 3362752441 254154386.4 134113821.2 23 63 38 41 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process;response to stimulus cell surface;chromosome;cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;nucleotide binding;protein binding;RNA binding "Pf00622, Pf13671" 3192 ENSG00000153187.18 HNRNPU 1 mRNA Splicing - Major Pathway Spliceosome 1 High P62906 60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2 0 249.917 62 20 260 20 217 24.8 9.94 7 20 10 9 12 189 37 22 78674192.8 7761647892 200842381.8 82238759.92 13 30 15 18 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00687 4736 ENSG00000198755.10 RPL10A 6 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P11142 Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1 0 281.423 57 37 253 29 646 70.9 5.52 17 29 28 32 29 66 76 82 50486480.24 1254610758 328692961 281468004.9 21 32 33 36 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;extracellular;membrane;nucleus;organelle lumen;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00012, Pf02463, Pf06723" 3312 ENSG00000109971.13 HSPA8 11 "Protein methylation; Clathrin-mediated endocytosis; Regulation of HSF1-mediated heat shock response; Golgi Associated Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; Lysosome Vesicle Biogenesis; CHL1 interactions; AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; mRNA Splicing - Major Pathway; Interleukin-4 and 13 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR)" Endocytosis; Longevity regulating pathway - multiple species; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 6 High P18621 60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3 0 230.576 65 16 248 15 184 21.4 10.17 7 16 8 6 14 199 22 13 16215142.82 6151689762 114821725.3 59921649.24 11 23 11 13 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00237 6139 ENSG00000215472.10; ENSG00000265681.7 RPL17 18 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 1 High Q9P2E9 Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5 0 609.534 71 89 248 89 1410 152.4 8.6 89 8 2 237 9 2 729460442.9 6858659757 107508567.9 37296444.47 16 94 30 34 0 High Q9H792 Inactive tyrosine-protein kinase PEAK1 OS=Homo sapiens OX=9606 GN=PEAK1 PE=1 SV=4 0 418.234 57 76 247 76 1746 193 6.89 35 57 53 52 117 78 7285352.961 177934841.9 391339313.1 195362619.2 14 45 64 61 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process cytoplasm;cytoskeleton catalytic activity;nucleotide binding;protein binding Pf00069 79834 ENSG00000173517.10 PEAK1 15 0 High P09874 Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4 0 454.521 72 60 245 60 1014 113 8.88 6 50 36 27 7 121 73 44 11814571.09 676123525.8 199192332.4 102883873.6 24 51 47 45 Met-loss+Acetyl [N-Term] cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063" 142 ENSG00000143799.12 PARP1 1 POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); SUMOylation of DNA damage response and repair proteins Base excision repair; NF-kappa B signaling pathway; Apoptosis 0 High P18124 60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1 0 244.503 64 27 241 27 248 29.2 10.65 10 27 17 14 18 165 33 25 30206687.96 11311991607 253282366.6 75986571.66 20 43 25 23 Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf00327, Pf08079" 6129 ENSG00000147604.13 RPL7 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P23396 40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2 0 212.474 81 24 221 24 243 26.7 9.66 9 24 14 13 13 162 24 22 38789887.57 9979410233 163973981.9 67616975.4 17 30 20 19 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen;ribosome catalytic activity;DNA binding;protein binding;RNA binding;structural molecule activity "Pf00189, Pf07650" 6188 ENSG00000149273.14 RPS3 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P09651 Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5 0 396.181 64 29 218 24 372 38.7 9.13 11 29 15 12 20 154 25 19 38291235.18 4200186380 265092480.5 185728963.3 13 35 19 16 cell communication;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3178 ENSG00000135486.17 HNRNPA1 12 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 5 High P07814 Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS PE=1 SV=5 0 575.83 60 72 217 71 1512 170.5 7.33 7 71 11 11 10 180 13 14 26491509.2 1321806063 35753744.47 39470987.47 23 71 25 33 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00458, Pf00587, Pf00749, Pf01406, Pf03129, Pf03950, Pf09180, Pf14497" 2058 ENSG00000136628.17 EPRS 1 tRNA modification in the nucleus and cytosol; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Porphyrin and chlorophyll metabolism; Aminoacyl-tRNA biosynthesis; Metabolic pathways 1 High P19474 E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1 0 190.675 60 32 217 32 475 54.1 6.38 23 13 29 32 53 19 69 76 125396118 360514084.4 521717103.1 473507226.6 26 24 35 35 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus;vacuole catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00097, Pf00622, Pf00643, Pf11789, Pf12128, Pf12678, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14570, Pf14634, Pf14835, Pf15227" 6737 ENSG00000132109.9 TRIM21 11 STING mediated induction of host immune responses; Antigen processing: Ubiquitination & Proteasome degradation; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA Systemic lupus erythematosus 0 High Q9BQG0 Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2 0 586.55 60 70 216 70 1328 148.8 9.28 1 69 6 5 1 202 8 5 5886840.495 2018790496 19399708.03 19853143.65 11 72 24 31 cell communication;cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf04931, Pf05793, Pf11593, Pf12815" 10514 ENSG00000132382.14 MYBBP1A 17 B-WICH complex positively regulates rRNA expression 0 High P15880 40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2 0 177.279 62 18 216 18 293 31.3 10.24 7 18 14 10 12 160 28 16 35661859.27 8442574607 145602133.2 46196826.15 13 22 15 13 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00333, Pf03719" 6187 ENSG00000140988.15 RPS2 16 "Peptide chain elongation; Protein methylation; Eukaryotic Translation Termination; Viral mRNA Translation; RMTs methylate histone arginines; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P0DMV9 Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1 0 257.397 56 32 215 22 641 70 5.66 23 23 29 26 45 41 64 65 51775923.71 282361466.1 467868833.5 310382082 21 26 32 30 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;receptor activity;RNA binding "Pf00012, Pf06723" 3304; 3303 ENSG00000232804.5; ENSG00000234475.5; ENSG00000231555.4; ENSG00000235941.5; ENSG00000204389.9; ENSG00000204388.6; ENSG00000212866.6; ENSG00000237724.5; ENSG00000224501.5 HSPA1B; HSPA1A 6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1 AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; Viral RNP Complexes in the Host Cell Nucleus; HSP90 chaperone cycle for steroid hormone receptors (SHR) Endocytosis; Longevity regulating pathway - multiple species; Prion diseases; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 6 High P17844 Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1 0 277.672 68 45 214 36 614 69.1 8.92 8 45 21 15 11 141 42 20 20346931.96 3477204208 109833298.3 53422464.52 22 46 28 29 Met-loss+Acetyl [N-Term] cell differentiation;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08061" 1655 ENSG00000108654.13 DDX5 17 mRNA Splicing - Major Pathway Spliceosome; Proteoglycans in cancer; Transcriptional misregulation in cancer 9 High P07437 Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2 0 247.426 71 25 213 4 444 49.6 4.89 14 21 20 23 24 62 51 76 95712211.5 230447377.2 52943813.34 70654431.74 3 7 7 6 cell division;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;extracellular;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 203068 ENSG00000232575.10; ENSG00000196230.12; ENSG00000227739.10; ENSG00000224156.10; ENSG00000235067.10; ENSG00000229684.10; ENSG00000183311.16; ENSG00000232421.10 TUBB 6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1 Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes Pathogenic Escherichia coli infection; Gap junction; Phagosome 1 High P46777 60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3 0 239.996 68 21 209 21 297 34.3 9.72 2 21 10 8 2 176 20 11 1640360.125 7194582832 102828800.1 35592964.73 6 30 15 17 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00861, Pf14204" 6125 ENSG00000122406.12 RPL5 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2 0 290.88 76 29 204 25 353 37.4 8.95 19 27 21 19 47 82 39 36 62244545.02 1745799593 278234400 180838057.6 17 30 21 23 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3181 ENSG00000122566.20 HNRNPA2B1 7 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway 0 High Q8NC51 Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2 0 356.99 58 33 199 33 408 44.9 8.65 33 4 5 185 7 7 1631203.154 3576956637 24744822.63 8754951.164 6 36 11 13 Met-loss [N-Term] regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf04774 26135 ENSG00000142864.14 SERBP1 1 0 High P05388 60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 0 262.674 66 22 197 22 317 34.3 5.97 4 22 11 11 6 147 24 20 17029825.26 7523586703 183803408.9 72742311.81 12 29 13 18 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00428, Pf00466" 6175 ENSG00000089157.15 RPLP0 12 Peptide chain elongation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Interleukin-12 family signaling Ribosome 0 High O00571 ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3 0 337.311 74 46 197 45 662 73.2 7.18 8 44 17 16 11 139 28 19 24857573.72 1818512390 105451945.3 72436109.56 17 46 26 26 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 1654 ENSG00000215301.9 DDX3X X Neutrophil degranulation Viral carcinogenesis; Hepatitis B; RIG-I-like receptor signaling pathway 2 High P40429 60S ribosomal protein L13a OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2 0 95.388 55 19 195 19 203 23.6 10.93 4 19 10 9 8 147 25 15 30278858.91 5927114420 157586433.7 45009279.25 8 24 10 11 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00572 23521 ENSG00000142541.16 RPL13A 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P26373 60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4 0 161.951 59 19 193 19 211 24.2 11.65 5 19 7 7 6 164 14 9 18788487.13 8035651963 187815575.6 72502120.22 8 25 14 15 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01294 6137 ENSG00000167526.13 RPL13 16 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9NZI8 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2 0 290.705 56 36 192 32 577 63.4 9.2 7 36 11 9 10 156 14 12 24317572.41 4791045168 80478820.64 37597186.65 23 45 20 22 cell proliferation;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding;translation regulator activity "Pf00013, Pf00076, Pf13014, Pf13893, Pf14259" 10642 ENSG00000159217.9 IGF2BP1 17 MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MicroRNAs in cancer 5 High Q13283 Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1 0 321.674 60 21 191 20 466 52.1 5.52 21 6 181 10 3601603.641 2014018358 18061963.08 112271151.1 6 30 12 11 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00076, Pf02136, Pf13893, Pf14259" 10146 ENSG00000145907.14 G3BP1 5 4 High P62241 40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2 0 144.621 65 15 186 15 208 24.2 10.32 7 15 11 9 9 135 20 22 15993210.77 8260110078 162794697.1 82340824.9 11 22 15 14 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01201 6202 ENSG00000142937.11 RPS8 1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P67809 Nuclease-sensitive element-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3 0 335.404 74 23 186 17 324 35.9 9.88 6 23 7 8 11 146 17 12 64417359.43 1847995397 80436630.02 56733628.49 13 31 12 13 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf00313 4904 ENSG00000065978.18 YBX1 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway 9 High P62753 40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1 0 206.742 56 21 184 21 249 28.7 10.84 7 20 11 6 9 152 16 7 17046185.94 6744720956 107164495.7 45059588.5 11 27 13 13 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01092 6194 ENSG00000137154.12 RPS6 9 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; mTORC1-mediated signalling; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome; Insulin signaling pathway; HIF-1 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Proteoglycans in cancer; mTOR signaling pathway; PI3K-Akt signaling pathway 0 High Q13428 Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3 0 304.643 38 53 184 53 1488 152 9.04 3 30 29 38 3 52 56 73 3212247.144 258077073.7 402677716 354281458.4 7 32 40 45 cell organization and biogenesis;regulation of biological process;transport cytosol;nucleus protein binding;RNA binding;transporter activity Pf03546 6949 ENSG00000070814.17 TCOF1 5 Ribosome biogenesis in eukaryotes 0 High P68371 Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1 0 213.722 68 25 181 1 445 49.8 4.89 11 20 17 22 21 51 43 66 59713623.13 575036032.9 238246570.4 422897165.6 18 27 27 29 cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 10383 ENSG00000188229.5 TUBB4B 9 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 32 High P27708 CAD protein OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3 0 247.505 32 55 179 55 2225 242.8 6.46 21 6 41 44 29 6 70 74 19424998.4 124141826.8 211883492.7 179222947.2 22 24 46 50 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00117, Pf00185, Pf00289, Pf00988, Pf01979, Pf02142, Pf02222, Pf02729, Pf02786, Pf02787, Pf07478, Pf07722, Pf13147, Pf13535, Pf13594, Pf15632" 790 ENSG00000084774.13 CAD 2 Pyrimidine biosynthesis "Alanine, aspartate and glutamate metabolism; Metabolic pathways; Pyrimidine metabolism" 0 High Q13616 Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2 0 250.895 59 49 178 49 776 89.6 8 15 37 42 16 71 91 2989859.12 243500967.2 263416713.9 265352119.3 9 21 41 49 cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol catalytic activity;protein binding "Pf00888, Pf10557" 8454 ENSG00000055130.15 CUL1 7 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Herpes simplex infection; Cell cycle 0 High P46781 40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3 0 92.4 66 21 176 21 194 22.6 10.65 8 21 13 9 11 127 23 15 25489136.68 11272328723 149117712.4 61633201.59 14 26 15 14 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity "Pf00163, Pf01479" 6203 ENSG00000274005.3; ENSG00000275323.3; ENSG00000277079.3; ENSG00000278081.3; ENSG00000277359.3; ENSG00000170889.13; ENSG00000274950.4; ENSG00000274626.3; ENSG00000278270.4; ENSG00000274646.4 RPS9 19; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P11940 Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2 0 280.358 69 42 174 28 636 70.6 9.5 16 38 14 13 25 104 27 18 29108218.49 1705193332 92369995.3 56924540.82 18 41 22 22 Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding;translation regulator activity "Pf00076, Pf00658, Pf13893, Pf14259" 26986 ENSG00000070756.15 PABPC1 8 AUF1 (hnRNP D0) binds and destabilizes mRNA; L13a-mediated translational silencing of Ceruloplasmin expression; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA RNA degradation; mRNA surveillance pathway; RNA transport 15 High Q12906 Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3 0 470.422 65 47 173 41 894 95.3 8.76 5 46 9 10 5 144 11 13 25403523.53 2222826749 47857809.01 30090283.44 12 48 18 15 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular;membrane;mitochondrion;nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf07528, Pf14709" 3609 ENSG00000129351.17 ILF3 19 6 High P31943 Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4 0 258.911 63 20 172 11 449 49.2 6.3 13 19 14 12 29 83 36 24 45884678.07 1096394141 143187565.6 90806609.38 14 26 18 19 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3187 ENSG00000169045.17; ENSG00000284254.1 HNRNPH1 5; CHR_HG30_PATCH mRNA Splicing - Major Pathway; FGFR2 alternative splicing 13 High Q7L2E3 ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1 0 420.171 69 69 172 69 1194 133.9 8.78 68 15 4 147 21 4 18382198.85 1816380096 47641698.67 23396709.1 21 69 32 28 Met-loss [N-Term]; Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717" 22907 ENSG00000132153.14 DHX30 3 0 High P62750 60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1 0 160.873 62 19 169 19 156 17.7 10.45 4 19 8 7 5 138 15 11 7896727.807 5245553585 108560221.2 41626646.12 6 23 13 13 cell organization and biogenesis;cell proliferation;metabolic process;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00276, Pf03939" 6147 ENSG00000198242.13 RPL23A 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P10412 Histone H1.4 OS=Homo sapiens OX=9606 GN=HIST1H1E PE=1 SV=2 0 109.966 47 16 165 5 219 21.9 11.03 7 16 7 9 13 123 14 15 8932141.75 2346705851 11971843 5644640.648 3 6 2 2 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00538 3008 ENSG00000168298.6 HIST1H1E 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 0 High Q14690 Protein RRP5 homolog OS=Homo sapiens OX=9606 GN=PDCD11 PE=1 SV=3 0 526.539 52 82 165 82 1871 208.6 8.87 82 4 161 4 54633139.54 935575376.9 36067017.69 27422761.55 15 78 23 29 metabolic process cytosol;nucleus protein binding;RNA binding "Pf00575, Pf13424, Pf13432" 22984 ENSG00000148843.13 PDCD11 10 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High P04350 Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2 0 196.884 65 23 165 2 444 49.6 4.88 10 17 16 19 18 46 41 60 1635202 2273927.438 4431858 1 2 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 10382 ENSG00000104833.11 TUBB4A 19 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 0 High P13010 X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3 0 301.457 61 41 163 41 732 82.7 5.81 1 36 28 23 1 72 52 38 26274738.99 366459448 171404413.6 85299607.81 17 40 34 33 cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf02735, Pf03730, Pf03731, Pf08785" 7520 ENSG00000079246.15 XRCC5 2 2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High P12956 X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2 0 266.869 62 39 162 39 609 69.8 6.64 4 35 25 21 4 64 55 39 27112384.62 518275263.8 195211399 115085798.8 12 36 30 31 Met-loss+Acetyl [N-Term] cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf02037, Pf02735, Pf03730, Pf03731" 2547 ENSG00000196419.12 XRCC6 22 2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High P35637 RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1 0 151.232 24 14 160 12 526 53.4 9.36 11 12 10 11 44 33 39 44 148033593.9 289314272 437036061.3 233399441.3 14 15 14 15 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf13893, Pf14259" 2521 ENSG00000089280.18 FUS 16 mRNA Splicing - Major Pathway Transcriptional misregulation in cancer 2 High P63261 "Actin, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=ACTG1 PE=1 SV=1" 0 175.358 71 20 155 1 375 41.8 5.48 14 17 14 16 26 46 44 39 1579585.75 8191989.797 7187662.75 1103372.023 2 3 2 2 Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus nucleotide binding;protein binding;structural molecule activity Pf00022 71 ENSG00000184009.9 ACTG1 17 Signaling by BRAF and RAF fusions; Formation of annular gap junctions; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Clathrin-mediated endocytosis; Interaction between L1 and Ankyrins; VEGFA-VEGFR2 Pathway; RHO GTPases activate IQGAPs; Signaling by RAS mutants; Recycling pathway of L1; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Translocation of GLUT4 to the plasma membrane; Adherens junctions interactions; EPH-ephrin mediated repulsion of cells; Paradoxical activation of RAF signaling by kinase inactive BRAF; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate Formins; Interleukin-20 family signaling Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis 0 High Q07020 60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2 0 108.661 49 12 154 12 188 21.6 11.72 3 12 7 7 9 108 20 17 30427085.66 9167064150 170099756.9 77297067.47 7 16 11 11 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00828 6141 ENSG00000063177.12 RPL18 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High O43143 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2 0 318.004 62 46 153 45 795 90.9 7.46 4 44 11 5 5 128 15 5 24735578.29 1159037972 26728557.56 8317212.656 10 45 14 18 metabolic process;response to stimulus cytoplasm;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717, Pf13401" 1665 ENSG00000109606.12 DHX15 4 mRNA Splicing - Major Pathway Spliceosome 1 High Q92841 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2 0 232.341 53 39 153 30 729 80.2 8.27 7 37 14 12 11 107 21 14 20546205.59 871229212.5 27377665.05 30592859.69 6 29 14 12 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 10521 ENSG00000100201.20 DDX17 22 0 High P62829 60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1 0 190.417 75 15 152 15 140 14.9 10.51 4 15 6 7 5 110 15 22 14156509.47 3838634847 95449301.2 90717730.87 9 20 9 12 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00238 9349 ENSG00000125691.12 RPL23 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q13885 Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1 0 148.647 49 19 151 1 445 49.9 4.89 9 14 14 17 19 40 34 58 124196.6484 3036441.25 1572876.5 2238999.531 1 1 1 2 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 7280 ENSG00000137267.5 TUBB2A 6 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 1 High P43243 Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2 0 342.635 59 42 149 42 847 94.6 6.25 5 41 10 7 9 119 13 8 5755757.79 1034710400 23842361.78 15296314.06 9 43 19 22 defense response;regulation of biological process;response to stimulus membrane;nucleus metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00076, Pf13893, Pf14259" 9782 ENSG00000015479.18; ENSG00000280987.4 MATR3 5 0 High P60709 "Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1" 0 167.361 71 20 149 1 375 41.7 5.48 13 17 14 16 23 44 43 39 42763975.5 368439416.7 306381636.1 149236639.7 14 19 20 21 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;nucleotide binding;protein binding;structural molecule activity Pf00022 60 ENSG00000075624.13 ACTB 7 Formation of annular gap junctions; Cell-extracellular matrix interactions; UCH proteinases; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; Factors involved in megakaryocyte development and platelet production; Translocation of GLUT4 to the plasma membrane; EPH-ephrin mediated repulsion of cells; Prefoldin mediated transfer of substrate to CCT/TriC; EPHB-mediated forward signaling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Folding of actin by CCT/TriC; DNA Damage Recognition in GG-NER; Regulation of actin dynamics for phagocytic cup formation; Interleukin-20 family signaling; Signaling by BRAF and RAF fusions; Clathrin-mediated endocytosis; VEGFA-VEGFR2 Pathway; HATs acetylate histones; RHO GTPases activate IQGAPs; Recycling pathway of L1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Adherens junctions interactions; RHO GTPases Activate WASPs and WAVEs; RHO GTPases Activate Formins; B-WICH complex positively regulates rRNA expression Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Gastric acid secretion; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis 21 High Q02543 60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2 0 102.765 65 18 148 18 176 20.7 10.71 3 18 9 6 6 111 22 9 13045192.16 5466563356 113011233.5 29806644.86 6 23 9 9 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01775 6142 ENSG00000105640.12 RPL18A 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P61353 60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2 0 107.137 67 12 148 12 136 15.8 10.56 8 12 7 7 15 97 22 14 24737220.36 6478237501 180065255.4 58591181.7 12 16 12 11 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00467, Pf01777" 6155 ENSG00000131469.12 RPL27 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q6PKG0 La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2 0 474.1 69 59 146 53 1096 123.4 8.82 1 59 2 1 1 142 2 1 2812828.672 931776307 57229219.14 34696381.57 5 58 17 21 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane protein binding;RNA binding;translation regulator activity Pf05383 23367 LARP1 5 6 High P16403 Histone H1.2 OS=Homo sapiens OX=9606 GN=HIST1H1C PE=1 SV=2 0 123.449 51 20 146 9 213 21.4 10.93 6 20 5 7 11 111 12 12 13853202.63 8573324625 118024555 72945853.36 7 20 11 14 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 3006 ENSG00000187837.3 HIST1H1C 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 11 High P13647 "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" 0 130.161 52 35 146 22 590 62.3 7.74 26 8 21 24 56 12 33 45 77045364.94 82498154.45 98755715.89 74372789.21 22 14 19 21 cell death;cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf02994, Pf03961, Pf04111, Pf05957, Pf12128" 3852 ENSG00000186081.11 KRT5 12 Formation of the cornified envelope; Type I hemidesmosome assembly 5 High P11387 DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2 0 270.547 58 49 145 43 765 90.7 9.31 49 4 1 140 4 1 5940253.432 1613334139 66182404.02 62901436.08 10 51 13 14 Met-loss+Acetyl [N-Term] cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf01028, Pf02919, Pf14370" 7150 ENSG00000198900.5 TOP1 20 SUMOylation of DNA replication proteins 6 High P32969 60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1 0 279.005 73 14 144 14 192 21.9 9.95 1 14 8 4 2 126 9 7 165281813 3816728315 51964004.83 23575193.74 7 26 17 20 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00347 6133 ENSG00000163682.15 RPL9 4 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62280 40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3 0 109.081 68 18 143 18 158 18.4 10.3 8 18 9 8 20 89 18 16 38848429.48 6892466306 92992090.38 51504045.09 12 22 12 12 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00366 6205 ENSG00000142534.6 RPS11 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q14684 Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3 0 395.969 62 40 141 40 758 84.4 9.76 1 40 2 2 1 136 2 2 6078323.543 1068032118 52585577.08 55740449.84 6 45 15 19 Met-loss [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding;RNA binding Pf05997 23076 ENSG00000160208.12 RRP1B 21 0 High P62277 40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2 0 101.077 56 16 140 16 151 17.2 10.54 7 16 9 9 15 82 29 14 14165020.75 5995143323 185438472.8 69683354.18 8 18 10 12 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00312, Pf08069" 6207 ENSG00000110700.6 RPS13 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High O76021 Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3 0 356.694 61 44 140 44 490 54.9 10.13 1 44 5 4 2 128 6 4 14832755.36 1741460477 47709182.89 9457024.585 10 44 14 20 Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding "Pf06030, Pf11797" 26156 ENSG00000171490.12 RSL1D1 16 0 High P05387 60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1 0 204.304 96 14 139 12 115 11.7 4.54 6 14 9 7 13 77 29 20 22156617 3421083860 176124125.5 80430114.21 9 18 11 13 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;structural molecule activity Pf00428 6181 ENSG00000177600.8 RPLP2 11 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 3 High P62249 40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2 0 102.947 73 17 138 17 146 16.4 10.21 9 17 7 9 11 98 17 12 12287040.14 5579478432 78246719.95 34557576.7 10 18 12 12 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00380 6217 ENSG00000105193.8 RPS16 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P16989 Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4 0 295.619 77 23 138 17 372 40.1 9.77 4 23 7 7 5 108 16 9 2549756.281 459032511.1 26865954.91 8250361.156 5 20 10 7 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding Pf00313 8531 ENSG00000060138.12 CSDA; YBX3 12 Tight junction 0 High P68104 Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1 0 189.62 70 21 138 21 462 50.1 9.01 10 17 15 13 20 48 30 40 35643466.35 739740048.1 210519370 231204723.6 11 19 18 21 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 1915 ENSG00000156508.17 EEF1A1 6 Peptide chain elongation; Protein methylation; Neutrophil degranulation; HSF1 activation RNA transport; Legionellosis 0 High P61313 60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2 0 126.891 58 14 137 14 204 24.1 11.62 7 14 9 7 10 107 13 7 14364972.99 7282084137 153851728.4 31107137.65 8 21 15 15 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00827 6138 ENSG00000174748.18 RPL15 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P48634 Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3 0 427.178 44 64 137 60 2157 228.7 9.45 64 137 7688535.969 458803442.7 13378478.16 10612441.39 8 61 13 12 cell differentiation cytoplasm;membrane;nucleus protein binding;RNA binding Pf07001 7916 ENSG00000204469.12 PRRC2A 6 4 High P68363 Tubulin alpha-1B chain OS=Homo sapiens OX=9606 GN=TUBA1B PE=1 SV=1 0 184.776 61 23 137 3 451 50.1 5.06 4 20 16 22 7 44 38 48 10518152.02 492550434.7 237754851 288093685.2 10 19 22 24 cell division;cell organization and biogenesis;response to stimulus;transport cytoplasm;cytoskeleton;membrane catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity "Pf00091, Pf03953" 10376 ENSG00000123416.15 TUBA1B 12 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome; Apoptosis 21 High P39019 40S ribosomal protein S19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2 0 111.471 71 17 137 17 145 16.1 10.32 4 17 10 3 5 108 17 7 14607105.81 6389463822 76007169.56 25819094.96 8 23 14 13 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01090 6223 ENSG00000105372.6 RPS19 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P84098 60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1 0 119.729 47 14 135 14 196 23.5 11.47 5 14 7 6 8 102 16 9 8193306.439 5122032336 165130247.3 82374520.88 6 19 9 13 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01280 6143 ENSG00000108298.9 RPL19 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P02533 "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" 0 108.481 57 26 135 9 472 51.5 5.16 21 6 16 18 60 10 31 34 56901489.62 60677120.76 80811541.48 58340977.93 15 10 16 14 cell death;cell differentiation;cell organization and biogenesis;response to stimulus cytoplasm;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf13514" 3861 ENSG00000186847.5 KRT14 17 Formation of the cornified envelope; Type I hemidesmosome assembly 14 High P62910 60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2 0 158.463 55 13 134 13 135 15.9 11.33 3 13 9 5 3 104 20 7 7767618.965 4808146385 93090959.47 32999803.13 9 27 12 11 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01655 6161 ENSG00000144713.12 RPL32 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62244 40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2 0 93.202 83 15 134 15 130 14.8 10.13 4 15 8 5 5 99 19 11 9452625.589 5392276101 109165584 60454324.1 8 18 11 16 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00410 6210 ENSG00000134419.15 RPS15A 16 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q9NVI7 ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A PE=1 SV=2 0 130.316 50 29 134 11 634 71.3 8.98 12 25 14 21 20 44 26 44 4384476.063 343196814.2 28136334.11 56336669.17 6 10 9 10 Met-loss+Acetyl [N-Term] cell growth;regulation of biological process membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf06745, Pf07728, Pf12037, Pf13207, Pf13401" 55210 ENSG00000197785.13 ATAD3A 1 0 High Q9Y383 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2 0 146.825 50 22 134 15 392 46.5 10.01 11 20 13 12 19 65 24 26 35336950.61 756948938.4 120401533.8 93525395.59 13 25 20 21 Met-loss+Acetyl [N-Term] cell organization and biogenesis nucleus;spliceosomal complex protein binding;RNA binding Pf03194 51631 ENSG00000146963.17 LUC7L2 7 10 High P38646 "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" 0 206.752 53 38 134 37 679 73.6 6.16 14 22 23 31 17 27 37 53 21512699.07 215683086 188628459.9 173406192.6 17 24 28 35 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;mitochondrion;nucleus;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00012, Pf06723" 3313 ENSG00000113013.12 HSPA9 5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Interleukin-12 family signaling; Cristae formation; Metabolism of proteins Tuberculosis; RNA degradation 1 High P51610 Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2 0 192.415 30 40 131 40 2035 208.6 7.46 15 31 30 17 62 52 7920097.01 129097714.4 164342032.1 125833915.3 8 20 33 35 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;protein binding "Pf01344, Pf13415, Pf13418, Pf13854, Pf13964" 3054 ENSG00000172534.13 HCFC1 X Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones; UCH proteinases Herpes simplex infection 0 High P61254 60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1 0 119.756 70 18 130 4 145 17.2 10.55 4 18 4 5 9 105 7 9 11337589.55 5224114808 96829000.53 35774164.39 8 22 12 12 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00467 6154 ENSG00000161970.12 RPL26 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 18 High P51991 Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2 0 240.437 52 26 130 24 378 39.6 9.01 8 26 11 12 10 84 16 20 12350606.72 851505048.9 90831611.25 56823903.46 14 27 17 17 Acetyl [N-Term] metabolic process;transport cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding;transporter activity "Pf00076, Pf13893, Pf14259" 220988 ENSG00000170144.20 HNRNPA3 2 mRNA Splicing - Major Pathway Spliceosome 0 High P05141 ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7 0 87.915 51 17 129 6 298 32.8 9.69 6 15 16 16 10 35 33 51 1478848.992 799697808.6 83362682.95 168111564 3 5 7 7 Met-loss+Acetyl [N-Term] regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;RNA binding;transporter activity Pf00153 292 ENSG00000005022.5 SLC25A5 X Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Regulation of insulin secretion cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High Q99570 Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3 0 215.303 39 46 129 46 1358 153 7.17 11 29 43 12 47 70 16363358.45 75206361.05 137093402.7 138249425.2 8 21 34 45 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;endosome;membrane;vacuole catalytic activity;nucleotide binding;protein binding "Pf00069, Pf00400" 30849 ENSG00000196455.7 PIK3R4 3 PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy Autophagy 0 High P27635 60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4 0 154.089 53 14 128 14 214 24.6 10.08 6 14 8 7 7 92 17 12 10416318.61 6082729826 133519208.7 48556829.17 6 22 12 13 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity Pf00252 6134 RPL10 X Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9BQE3 Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1 0 150.739 57 22 127 2 449 49.9 5.1 4 18 14 20 7 40 35 45 9860087.5 2825200.5 3440420.5 2 1 1 cell division;cell organization and biogenesis;transport cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953" 84790 ENSG00000167553.15 TUBA1C 12 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome; Apoptosis 0 High Q5T9A4 ATPase family AAA domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ATAD3B PE=1 SV=1 0 132.874 52 30 127 12 648 72.5 9.2 11 23 14 20 20 41 25 41 21405712.86 368592417.5 72004738.37 121121492.2 16 27 17 23 Met-loss+Acetyl [N-Term] transport membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf07726, Pf07728, Pf12037, Pf13207, Pf13401" 83858 ENSG00000160072.19 ATAD3B 1 Neutrophil degranulation 18 High P62269 40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3 0 76.366 63 18 127 18 152 17.7 10.99 4 18 8 10 5 84 18 20 58107998.97 6249510580 75244212.17 48525706.23 7 22 11 13 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00416 6222 ENSG00000223367.6; ENSG00000096150.9; ENSG00000235650.6; ENSG00000226225.6; ENSG00000231500.6 RPS18 6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P61978 Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1 0 206.045 61 26 126 26 463 50.9 5.54 7 25 12 11 8 82 22 14 8041518.008 1249590761 68485811.31 80100754.81 10 29 20 18 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00013, Pf08067, Pf13014, Pf13083" 3190 ENSG00000165119.20 HNRNPK 9 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Viral carcinogenesis; MicroRNAs in cancer; Spliceosome; Herpes simplex infection 0 High P30050 60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1 0 87.943 69 10 126 10 165 17.8 9.42 5 10 7 6 8 85 20 13 14870260.66 6036764611 177815150.6 60136887 5 13 6 7 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00298, Pf03946" 6136 ENSG00000197958.12 RPL12 9 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62888 60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2 0 128.994 67 9 125 9 115 12.8 9.63 1 9 7 5 4 99 12 10 4185655.281 5408111224 52841930.42 22915986.45 4 17 11 9 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01248 6156 ENSG00000156482.10 RPL30 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P25398 40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3 0 195.525 77 11 125 11 132 14.5 7.21 4 11 5 3 4 105 11 5 11675641.2 3663535326 33424839.05 9740656.182 9 17 8 6 Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01248 6206 ENSG00000112306.7 RPS12 6 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High O43822 Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1 0 129.337 82 19 124 19 256 28.3 7.34 14 17 14 26 46 52 1970048.722 227603061.8 582002583.6 543753092.1 3 16 20 20 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion protein binding "Pf12799, Pf13855, Pf14580" 755 ENSG00000160226.15 C21orf2 21 0 High Q92499 ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2 0 331.043 67 42 124 42 740 82.4 7.23 8 41 12 8 8 89 17 10 16655808.13 706884361.6 37713985.91 26034149.95 16 41 19 22 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf00622" 1653 ENSG00000079785.14 DDX1 2 tRNA processing in the nucleus 0 High O43390 Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1 0 237.968 55 31 123 22 633 70.9 8.13 3 31 12 9 3 90 16 14 63651772.63 1857096232 41818484.63 32688863.75 9 33 17 20 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10236 ENSG00000282958.1; ENSG00000125944.18 HNRNPR 1; CHR_HSCHR1_4_CTG3 mRNA Splicing - Major Pathway 10 High Q92974 Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4 0 206.836 51 43 123 43 986 111.5 7.27 24 24 31 33 43 47 6612597.699 180602576.8 106628171 94883833.04 12 30 35 37 cell division;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane metal ion binding;protein binding "Pf00130, Pf00169, Pf00621, Pf07649" 9181 ENSG00000116584.17 ARHGEF2 1 G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle Pathogenic Escherichia coli infection 0 High P15927 Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1 0 206.386 91 14 122 14 270 29.2 6.15 1 10 14 11 2 24 54 42 2769433.703 349391564 819377166.9 578840428.9 4 14 22 25 Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf08784 6118 ENSG00000117748.9 RPA2 1 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High P46778 60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2 0 89.333 56 13 121 13 160 18.6 10.49 5 13 6 6 8 88 13 12 144407848.5 5073455552 118938326.4 45734700.51 9 18 10 13 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01157 6144 ENSG00000122026.10 RPL21 13 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P83731 60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1 0 77.006 58 15 121 15 157 17.8 11.25 7 15 10 7 9 85 19 8 24692322.52 5155328291 124263959.8 48495576.38 12 20 11 14 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01246 6152 ENSG00000114391.12 RPL24 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62841 40S ribosomal protein S15 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2 0 240.645 70 9 120 9 145 17 10.39 1 9 3 1 1 107 8 4 24377932.29 2515353220 16439911.1 3695541.456 10 19 6 13 cell differentiation;cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity Pf00203 6209 ENSG00000115268.9 RPS15 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q9H0A0 RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2 0 377.359 56 48 120 48 1025 115.7 8.27 48 7 1 111 8 1 40419964.84 941931685.6 16444800.23 9915906.894 12 54 18 19 metabolic process;regulation of biological process membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00583, Pf05127, Pf08351, Pf13508, Pf13718, Pf13725" 55226 ENSG00000135372.8 NAT10 11 rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P62263 40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3 0 196.683 72 13 120 13 151 16.3 10.05 2 13 7 8 5 86 16 13 7948838.422 3782813548 59559005.8 41518352.86 4 16 12 13 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity Pf00411 6208 ENSG00000164587.11 RPS14 5 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62081 40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1 0 197.188 74 20 120 20 194 22.1 10.1 3 20 9 6 6 92 13 9 6839977.643 4898297676 39172914.19 18942300.21 7 26 11 14 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01251 6201 ENSG00000171863.12 RPS7 2 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62913 60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2 0 126.844 64 14 119 14 178 20.2 9.6 2 14 5 2 2 97 12 8 12477870.78 4810361520 104634754.5 38820893.59 6 20 8 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00281, Pf00673" 6135 ENSG00000142676.12 RPL11 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P41252 "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS PE=1 SV=2" 0 291.634 48 51 119 51 1262 144.4 6.15 3 50 7 10 4 94 9 12 13889566.11 790629938.2 11819911.53 14901110.02 13 48 13 23 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00133, Pf01406, Pf08264, Pf09334" 3376 ENSG00000196305.17 IARS 9 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High O15226 NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2 0 287.11 61 52 119 52 690 77.6 8.79 1 50 6 3 1 106 9 3 7542359.578 959713078.3 12519891.97 7826205.288 8 49 10 18 metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf01424, Pf01585, Pf12656" 55922 ENSG00000186416.13 NKRF X 0 High P16402 Histone H1.3 OS=Homo sapiens OX=9606 GN=HIST1H1D PE=1 SV=2 0 95.113 50 16 117 7 221 22.3 11.02 4 16 5 6 8 86 12 11 276275782.8 1453305472 718241973.3 7 1 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;RNA binding Pf00538 3007 ENSG00000124575.6 HIST1H1D 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 0 High P23246 "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" 0 180.908 42 24 116 23 707 76.1 9.44 12 22 13 14 20 56 19 21 25662005.71 669898909.6 91804773.92 76008036.03 14 24 16 19 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 6421 ENSG00000116560.10 SFPQ 1 PTK6 Regulates Proteins Involved in RNA Processing 1 High P26599 Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1 0 335.697 76 27 115 23 531 57.2 9.17 3 26 6 8 4 93 9 9 5099100.531 1995864273 39568693.94 12869222.17 7 35 14 18 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 5725 ENSG00000011304.19 PTBP1 19 mRNA Splicing - Major Pathway; FGFR2 alternative splicing 5 High Q99459 Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2 0 370.096 65 49 115 49 802 92.2 8.18 48 3 1 109 5 1 131282614.7 795569859.9 18201720.6 14713853.06 9 48 15 16 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00249, Pf11831, Pf13921" 988 ENSG00000096401.7 CDC5L 6 mRNA Splicing - Major Pathway Spliceosome 0 High Q9NX58 Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=2 0 343.697 66 32 115 32 379 43.6 9.54 32 1 1 113 1 1 4646187.645 1659377906 4407412.063 43219725.83 4 37 6 4 Met-loss [N-Term] nucleus metal ion binding;protein binding;RNA binding Pf08790 55646 LYAR 4 0 High Q9UQ35 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2 0 165.131 17 33 114 33 2752 299.4 12.06 12 8 22 21 21 8 44 41 25399049.75 338033981.3 155362910.7 263616838.1 13 16 25 28 metabolic process nucleus;spliceosomal complex nucleotide binding;protein binding;RNA binding 23524 ENSG00000167978.16 SRRM2 16 mRNA Splicing - Major Pathway 0 High P50914 60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4 0 54.264 40 10 114 10 215 23.4 10.93 5 10 6 5 7 79 15 13 14204295.67 4460901054 118368246.5 46353853.51 8 14 7 9 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01929 9045 ENSG00000188846.13 RPL14 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q12905 Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2 0 280.484 84 25 114 25 390 43 5.26 3 24 10 6 4 86 16 8 4723694.109 1106713875 55041794.55 22664567.84 7 24 14 14 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding Pf07528 3608 ENSG00000143621.16 ILF2 1 Neutrophil degranulation 0 High P13639 Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4 0 208.411 53 39 113 38 858 95.3 6.83 3 34 14 14 3 66 24 20 18821983.66 1554047309 49149478.37 33768229.86 14 35 24 24 Met-loss [N-Term] cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 1938 ENSG00000167658.15 EEF2 19 Peptide chain elongation; Protein methylation; Synthesis of diphthamide-EEF2; Neutrophil degranulation; Uptake and function of diphtheria toxin Oxytocin signaling pathway; AMPK signaling pathway 1 High P08779 "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" 0 81.342 46 22 113 8 473 51.2 5.05 14 5 11 18 50 8 23 32 5070962.109 5423452.688 12241232.56 10947657.75 5 2 2 5 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;regulation of biological process;response to stimulus cytoskeleton;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf07888, Pf13514" 3868 ENSG00000186832.8 KRT16 17 Formation of the cornified envelope 0 High P46013 Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2 0 409.682 34 72 113 72 3256 358.5 9.45 71 4 1 107 5 1 8772101.833 464085512.3 55274673.51 39298044.12 10 62 17 17 cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus DNA binding;nucleotide binding;protein binding;RNA binding "Pf00498, Pf08065, Pf15276" 4288 ENSG00000148773.13 MKI67 10 0 High P51114 Fragile X mental retardation syndrome-related protein 1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3 0 307.559 68 42 111 39 621 69.7 6.15 1 41 4 6 1 99 5 6 4838495.707 872656127.6 20871096.93 7240518.208 7 41 15 14 Met-loss+Acetyl [N-Term] cell death;cell differentiation;development;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00013, Pf05641, Pf12235, Pf13014" 8087 ENSG00000114416.17 FXR1 3 Signaling by BRAF and RAF fusions RNA transport 3 High P46782 40S ribosomal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4 0 141.777 56 15 110 15 204 22.9 9.72 5 14 8 5 6 87 10 7 8669808.817 3468611375 54496709.83 22972095.47 12 20 11 13 Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00177 6193 ENSG00000083845.8 RPS5 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P35244 Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1 0 139.497 88 8 110 8 121 13.6 5.08 1 8 7 7 1 19 51 39 4025288.977 145307290.8 489651818.4 380133589.3 8 14 15 15 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding Pf08661 6119 ENSG00000106399.11 RPA3 7 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High Q9UNX3 60S ribosomal protein L26-like 1 OS=Homo sapiens OX=9606 GN=RPL26L1 PE=1 SV=1 0 108.696 70 17 110 3 145 17.2 10.55 3 17 3 4 8 88 6 8 61513622.5 131660.6406 1821728.875 3 1 1 metabolic process ribosome RNA binding;structural molecule activity Pf00467 51121 ENSG00000037241.7 RPL26L1 5 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P61513 60S ribosomal protein L37a OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2 0 59.378 60 6 110 6 92 10.3 10.43 3 6 3 3 5 90 10 5 15931629.72 2502916763 59930941 32802002.5 4 9 5 5 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity Pf01780 6168 ENSG00000197756.9 RPL37A 2 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9UMS4 Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1 0 280.368 81 22 109 22 504 55.1 6.61 2 22 7 4 3 93 9 4 6740932.875 1965685526 19408603.75 11935866.32 10 23 11 9 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus;spliceosomal complex catalytic activity;metal ion binding;protein binding "Pf00400, Pf04564, Pf08606, Pf11789" 27339 ENSG00000110107.8 PRPF19 11 Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER Ubiquitin mediated proteolysis; Spliceosome 0 High P68133 "Actin, alpha skeletal muscle OS=Homo sapiens OX=9606 GN=ACTA1 PE=1 SV=1" 0 73.612 33 12 106 2 377 42 5.39 9 12 9 10 19 30 29 28 18374832 52855772.5 26027252.75 13228991.06 1 1 1 2 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;structural molecule activity Pf00022 58 ENSG00000143632.14 ACTA1 1 Striated Muscle Contraction 0 High P46783 40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1 0 96.884 79 16 106 15 165 18.9 10.15 3 16 6 3 3 89 10 4 4179178.445 3368071039 35568789.55 14164443.32 6 17 8 8 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf03501 6204 ENSG00000124614.13 RPS10 6 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 1 High P46779 60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3 0 49.948 54 10 106 10 137 15.7 12.02 3 10 6 4 6 83 11 6 10760439.68 5354265061 116098519.1 74720553.06 6 16 14 12 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01778 6158 ENSG00000108107.14 RPL28 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P02538 "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" 0 102.17 45 26 105 12 564 60 8 15 7 16 22 34 11 20 40 9745051.875 171656086.5 8668599.531 17043315.81 6 3 6 10 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf04111, Pf13166" 3853 ENSG00000205420.10 KRT6A 12 Formation of the cornified envelope 1 High P14868 "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS PE=1 SV=2" 0 159.841 65 30 105 30 501 57.1 6.55 8 29 12 12 11 66 13 15 365160652.4 1027550395 33166899.5 33049301.86 14 29 13 18 cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf01336" 1615 ENSG00000115866.10 DARS 2 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High O95625 Zinc finger and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ZBTB11 PE=1 SV=2 0 179.144 40 36 104 36 1053 119.3 8.66 15 28 21 21 52 31 1880146.877 117778715.7 226883580.3 85258213.23 5 21 32 31 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00651, Pf13465" 27107 ENSG00000066422.4 ZBTB11 3 0 High P62258 14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1 0 103.128 67 21 104 18 255 29.2 4.74 2 8 19 18 2 13 47 42 1745496.891 81583600.84 269477931.7 236896418.6 4 8 22 23 Acetyl [N-Term] cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding;RNA binding Pf00244 7531 ENSG00000108953.16; ENSG00000274474.3 YWHAE 17; CHR_HSCHR17_2_CTG2 Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; NADE modulates death signalling; Translocation of GLUT4 to the plasma membrane; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by Hippo; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Regulation of HSF1-mediated heat shock response; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; RAB GEFs exchange GTP for GDP on RABs; HSF1 activation; TP53 Regulates Metabolic Genes; Signalling by NGF; RHO GTPases activate PKNs Viral carcinogenesis; Epstein-Barr virus infection; Neurotrophin signaling pathway; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 3 High Q06787 Synaptic functional regulator FMR1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1 0 264.356 59 32 104 29 632 71.1 7.42 32 3 2 99 3 2 13029028.05 600728756 4314211.662 530522.625 6 33 4 1 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;translation regulator activity "Pf00013, Pf05641, Pf12235, Pf13014" 2332 ENSG00000102081.13 FMR1 X RNA transport 0 High O60506 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2 0 255.035 58 31 104 21 623 69.6 8.59 4 31 7 8 4 78 11 11 7677439.639 512855249.9 10551953.79 16783234.89 10 21 8 12 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10492 ENSG00000135316.17 SYNCRIP 6 0 High Q9BUJ2 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2 0 218.678 39 29 103 28 856 95.7 6.92 5 23 15 9 8 49 29 17 40537076.67 296070055.8 54351449.01 29083574.27 12 27 19 18 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf13671" 11100 ENSG00000105323.16 HNRNPUL1 19 mRNA Splicing - Major Pathway Influenza A 0 High Q15233 Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4 0 127.746 46 23 102 22 471 54.2 8.95 10 22 12 12 15 47 18 22 15455292.41 360241472.7 85848708.17 40382218.61 14 22 16 17 defense response;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 4841 ENSG00000147140.15 NONO X 0 High O14654 Insulin receptor substrate 4 OS=Homo sapiens OX=9606 GN=IRS4 PE=1 SV=1 0 230.235 49 42 102 42 1257 133.7 8.44 8 34 8 15 10 63 11 18 18702722.55 898996940.1 26788201.9 30534243.41 13 34 16 28 regulation of biological process;response to stimulus cytosol;membrane protein binding;signal transducer activity "Pf00169, Pf02174" 8471 ENSG00000133124.11 IRS4 X IRS-related events triggered by IGF1R Longevity regulating pathway - multiple species; Insulin signaling pathway; FoxO signaling pathway; cGMP-PKG signaling pathway; Type II diabetes mellitus; AMPK signaling pathway; Regulation of lipolysis in adipocytes; Adipocytokine signaling pathway; Longevity regulating pathway 0 High P12236 ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4 0 64.273 55 18 102 7 298 32.8 9.74 4 14 13 17 7 28 25 42 13244296.57 362471050.2 223567324.2 476073486.3 7 18 15 19 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf00153 293 ENSG00000169100.13 SLC25A6 X|Y; X Mitochondrial protein import; Regulation of insulin secretion; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Influenza Virus Induced Apoptosis; Metabolism of proteins cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Influenza A; Calcium signaling pathway 13 High P18077 60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2 0 62.679 63 13 102 13 110 12.5 11.06 5 13 8 7 9 67 14 12 12763815.69 5297422746 150672826.4 41489835.62 10 19 12 10 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01247 6165 ENSG00000182899.14 RPL35A 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q7KZF4 Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1 0 312.199 61 45 101 45 910 101.9 7.17 45 101 2393857.34 854453040.5 3511038.48 7036177.957 8 43 7 9 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding "Pf00565, Pf00567" 27044 ENSG00000197157.10 SND1 7 Signaling by BRAF and RAF fusions Viral carcinogenesis; Epstein-Barr virus infection 0 High Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1 0 144.262 39 32 100 32 887 101.5 6.81 9 25 30 11 37 52 1433243.375 79882865.89 101752355.7 104517971.8 4 17 29 31 cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endosome;membrane;vacuole catalytic activity;nucleotide binding;protein binding "Pf00454, Pf00613, Pf00792" 5289 ENSG00000078142.12 PIK3C3 18 PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy Phosphatidylinositol signaling system; Tuberculosis; Inositol phosphate metabolism; Phagosome; Autophagy; Metabolic pathways 0 High Q9P258 Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2 0 233.898 61 27 99 27 522 56 8.78 2 26 7 5 2 78 13 6 24915057.97 645136219.5 21091405.04 10201095.11 6 26 17 17 cell division;cell organization and biogenesis;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding "Pf00415, Pf13540" 55920 ENSG00000281540.2; ENSG00000179051.13 RCC2 1; CHR_HG2095_PATCH Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins 0 High P14866 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2 0 267.183 62 27 99 26 589 64.1 8.22 4 27 4 9 5 79 6 9 4248365.389 598906116.6 21210236.1 17661930.93 5 31 12 14 metabolic process;regulation of biological process cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3191 ENSG00000282947.1; ENSG00000104824.16 HNRNPL 19; CHR_HG26_PATCH mRNA Splicing - Major Pathway 1 High P35658 Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2 0 217.623 33 43 98 43 2090 213.5 7.47 4 26 34 4 42 52 4093647.688 38005261.15 107356438.9 78199186.34 3 14 30 34 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus protein binding;structural molecule activity;transporter activity 8021 ENSG00000126883.16 NUP214 9 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; HuR (ELAVL1) binds and stabilizes mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins Epstein-Barr virus infection; RNA transport 0 High Q86UE4 Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2 0 308.599 69 39 97 39 582 63.8 9.32 39 97 5775181.688 913922541.9 34977430.55 23146766.98 3 39 18 19 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus protein binding;RNA binding 92140 ENSG00000147649.9 MTDH 8 0 High Q9UJV9 Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2 0 134.66 52 29 97 29 622 69.8 6.84 13 20 14 18 19 32 21 25 138239959.9 218159257.8 54653631.05 55102383.47 18 23 22 23 cell death;cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf13307" 51428 ENSG00000183258.11 DDX41 5 IRF3-mediated induction of type I IFN; Regulation of innate immune responses to cytosolic DNA 0 High Q15046 Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS PE=1 SV=3 0 239.215 57 32 96 32 597 68 6.35 2 32 4 2 2 88 4 2 9281566.125 667109191.9 14353306.6 9431294.16 7 35 8 7 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf00587, Pf01336" 3735 ENSG00000065427.14 KARS 16 Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High P42285 Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3 0 301.264 51 43 96 43 1042 117.7 6.52 1 43 2 1 93 2 7057372.642 567381164.6 15360382.22 24994130.58 10 43 15 23 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf04851, Pf08148, Pf13234" 23517 ENSG00000039123.15 SKIV2L2 5 Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway RNA degradation 0 High Q9HCE1 Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2 0 279.427 56 44 95 44 1003 113.6 8.82 42 6 2 86 7 2 6926266.387 775607204.2 19396270.16 12807452.43 9 43 12 18 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding;RNA binding "Pf13086, Pf13087, Pf13245, Pf13401, Pf13604" 4343 ENSG00000155363.18 MOV10 1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High Q5VT25 Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1 0 190.794 34 49 95 49 1732 197.2 6.58 6 35 29 8 50 37 389957.0697 38303107.13 123091660.8 66323906.91 4 14 39 39 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;extracellular;Golgi catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00038, Pf00069, Pf00130, Pf00169, Pf00433, Pf00769, Pf00780, Pf01442, Pf01576, Pf02463, Pf03999, Pf04012, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06160, Pf06785, Pf07714, Pf07888, Pf08317, Pf08826, Pf09726, Pf09730, Pf09755, Pf10174, Pf10498, Pf12037, Pf12128, Pf12718, Pf12795, Pf13514, Pf13851, Pf13868, Pf14362, Pf14531, Pf14915, Pf15558, Pf15619" 8476 ENSG00000143776.18 CDC42BPA 1 0 High P35580 Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3 0 256.31 33 52 95 39 1976 228.9 5.54 4 36 25 11 4 44 34 13 12638072.71 452869022.2 63849138.43 25946844.33 18 40 34 25 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf00063, Pf00769, Pf01496, Pf01576, Pf02736, Pf04111, Pf05622, Pf05911, Pf06637, Pf07888, Pf09726, Pf12128, Pf13094, Pf13514" 4628 ENSG00000133026.12 MYH10 17 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Salmonella infection; Regulation of actin cytoskeleton 12 High Q01780 Exosome component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2 0 331.69 64 44 95 44 885 100.8 8.46 44 2 93 2 138264355 804722649.5 33376901.25 9419358.814 7 42 14 14 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00570, Pf01612, Pf08066" 5394 ENSG00000171824.13 EXOSC10 1 Major pathway of rRNA processing in the nucleolus and cytosol RNA degradation 0 High Q13310 Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1 0 211.061 53 33 94 19 644 70.7 9.26 8 31 6 5 11 68 9 6 57833657.63 269284149.3 4258953.281 1112278.969 3 19 4 4 coagulation;metabolic process cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf00658, Pf13893, Pf14259" 8761 ENSG00000090621.13 PABPC4 1 RNA degradation; mRNA surveillance pathway; RNA transport 0 High P35251 Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4 0 301.109 51 46 94 46 1148 128.2 9.36 1 46 6 2 1 85 6 2 16343118.45 476888616.9 3773665266 4159161322 11 47 20 17 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding "Pf00004, Pf00533, Pf03215, Pf05496, Pf06414, Pf08519, Pf12738, Pf13207, Pf13238" 5981 ENSG00000035928.15 RFC1 4 Translesion synthesis by POLK; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Dual incision in TC-NER; PCNA-Dependent Long Patch Base Excision Repair DNA replication; Mismatch repair; Nucleotide excision repair 0 High P54136 "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS PE=1 SV=2" 0 251.314 63 38 93 38 660 75.3 6.68 3 37 6 7 3 76 7 7 8491604.844 552000233.3 19420743.41 13373160.26 11 39 18 21 Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00750, Pf03485, Pf05746" 5917 ENSG00000113643.8 RARS 5 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High O95793 Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2 0 307.028 59 35 93 33 577 63.1 9.44 35 2 91 2 7569951.363 615686104 13260226.86 12312670.02 10 39 7 12 regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane protein binding;RNA binding "Pf00035, Pf14709" 6780 ENSG00000124214.19 STAU1 20 2 High P55795 Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1 0 169.532 55 17 93 9 449 49.2 6.3 7 17 6 5 15 50 18 10 1032013 109161448.3 4897190.656 1838233.5 1 9 2 1 Acetyl [N-Term] metabolic process cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3188 ENSG00000126945.8 HNRNPH2 X mRNA Splicing - Major Pathway 0 High P41091 Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3 0 217.882 58 23 93 23 472 51.1 8.4 23 4 3 86 4 3 5055598.023 1230725534 46151878.05 41913237.34 4 23 11 11 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] metabolic process;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03144, Pf09173" 1968 ENSG00000130741.10 EIF2S3 X "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition" RNA transport 0 High P35579 Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4 0 241.422 30 50 92 39 1960 226.4 5.6 5 40 23 10 5 47 29 11 10227672.73 234299902.7 45075684.21 181346504.9 13 33 25 23 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00063, Pf01442, Pf01496, Pf01576, Pf01765, Pf02736, Pf03962, Pf04111, Pf04156, Pf05911, Pf06637, Pf07888, Pf09731, Pf11068, Pf11559, Pf12128, Pf13094" 4627 ENSG00000100345.20 MYH9 22 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Salmonella infection; Regulation of actin cytoskeleton 3 High Q6P158 Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2 0 336.301 44 50 91 47 1386 155.5 7.71 50 3 88 3 5750518.688 476357447.4 7690412.906 8640627.885 8 48 8 15 metabolic process mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf00642, Pf04408, Pf07717, Pf13191" 90957 ENSG00000163214.20 DHX57 2 3 High P78527 DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3 0 165.619 15 58 90 58 4128 468.8 7.12 3 22 50 3 30 57 70812504.63 66427020.36 50998946.21 66469737.47 7 21 39 51 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00454, Pf02259, Pf02260, Pf08163" 5591 ENSG00000253729.7 PRKDC 8 Nonhomologous End-Joining (NHEJ); E3 ubiquitin ligases ubiquitinate target proteins; IRF3-mediated induction of type I IFN Non-homologous end-joining; Cell cycle 0 High Q96F24 Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1 0 139.735 68 18 90 18 287 32.4 5.87 15 8 15 25 19 46 2319059.707 131223852.5 101485141.3 153226604.7 6 17 12 17 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;vacuole DNA binding;protein binding "Pf02183, Pf04212, Pf04977, Pf08961" 29982 ENSG00000148572.15 NRBF2 10 Nuclear Receptor transcription pathway 0 High P63173 60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2 0 55.431 63 8 89 8 70 8.2 10.1 4 8 4 7 8 46 16 19 4017918.156 764902441.6 29292393.44 43751401.7 4 8 6 7 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;ribosome RNA binding;structural molecule activity Pf01781 6169 ENSG00000172809.12 RPL38 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8TDD1 ATP-dependent RNA helicase DDX54 OS=Homo sapiens OX=9606 GN=DDX54 PE=1 SV=2 0 257.419 52 40 89 39 881 98.5 10.02 40 4 2 82 5 2 2207444 585497466.9 11667598.28 6907984.07 6 40 11 10 Met-loss [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08147" 79039 ENSG00000123064.12 DDX54 12 1 High Q08J23 tRNA (cytosine(34)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2 0 272.723 72 47 88 47 767 86.4 6.77 47 1 1 86 1 1 13507064.98 428342834.9 6759453.955 4983196.414 14 45 11 12 cell division;metabolic process cytoplasm;cytoskeleton;nucleus catalytic activity;RNA binding "Pf01189, Pf13659" 54888 ENSG00000037474.14 NSUN2 5 tRNA modification in the nucleus and cytosol 0 High Q8N3C0 Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3 0 370.843 38 60 88 60 2202 251.3 7.09 60 88 5828634.594 301406061.9 5577888.797 4608496.994 11 57 7 12 cell proliferation;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02889, Pf13401" 10973 ENSG00000112249.13 ASCC3 6 ALKBH3 mediated reversal of alkylation damage 0 High Q06830 Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1 0 125.069 77 18 88 15 199 22.1 8.13 8 18 10 11 13 38 19 18 22045196.74 468257177.6 152015273.9 82440970.16 10 17 14 16 cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00578, Pf08534, Pf10417" 5052 ENSG00000117450.13 PRDX1 1 TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species Peroxisome 4 High P08708 40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2 0 140.937 63 11 88 11 135 15.5 9.85 3 10 7 4 8 55 15 10 60316707.66 2522223761 51068731.66 29735292.09 7 15 11 9 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf00833 6218 ENSG00000278229.2; ENSG00000182774.10 RPS17; RPS17L 15; CHR_HSCHR15_5_CTG8 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62266 40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3 0 74.826 55 9 88 9 143 15.8 10.49 6 9 5 2 8 69 7 4 16437976.44 3764949962 48862876.16 14311506.73 8 11 6 6 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00164 6228 ENSG00000186468.12 RPS23 5 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P52597 Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3 0 180.433 71 18 87 16 415 45.6 5.58 4 18 8 8 10 56 11 10 4547106.557 634577505.4 26267078.55 22157852.75 4 19 9 10 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3185 ENSG00000169813.16 HNRNPF 10 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Interleukin-12 family signaling 0 High Q9Y3I0 tRNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1 0 213.926 62 28 86 28 505 55.2 7.23 7 27 10 11 8 52 13 13 11144361.87 659639095.8 51303876.73 36535483 12 27 18 20 metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf01139 51493 ENSG00000100220.11 C22orf28; RTCB 22 tRNA processing in the nucleus 0 High P13646 "Keratin, type I cytoskeletal 13 OS=Homo sapiens OX=9606 GN=KRT13 PE=1 SV=4" 0 37.629 17 9 86 1 458 49.6 4.96 8 4 5 6 31 9 21 25 189106.1094 1038980.625 1 1 cell death;cell organization and biogenesis;response to stimulus cytoskeleton;cytosol;nucleus protein binding;structural molecule activity Pf00038 3860 ENSG00000171401.14 KRT13 17 Formation of the cornified envelope 0 High P51116 Fragile X mental retardation syndrome-related protein 2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2 0 246.672 56 32 86 28 673 74.2 6.23 32 4 2 79 5 2 1160722.407 543208166.8 8342191.234 4508956.26 4 32 7 8 regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00013, Pf05641, Pf12235, Pf13014" 9513 ENSG00000129245.11 FXR2 17 RNA transport 2 High P08238 Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4 0 132.963 38 28 85 12 724 83.2 5.03 12 19 17 15 33 37 2275050.346 106433868.2 91386059.25 70518409.95 3 16 22 24 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 3326 ENSG00000096384.19 HSP90AB1 6 Sema3A PAK dependent Axon repulsion; HSF1 activation; Attenuation phase; Neutrophil degranulation; Aryl hydrocarbon receptor signalling; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; PI3K-Akt signaling pathway; Antigen processing and presentation 14 High Q9Y520 Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4 0 290.715 23 49 84 45 2896 316.7 9.13 49 84 30863495.63 243623210.3 36638597.44 28049056.48 2 46 13 12 cell differentiation membrane protein binding;RNA binding Pf07001 23215 PRRC2C 1 0 High P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1 0 142.091 63 18 83 4 330 37.5 6.33 1 15 11 11 1 40 25 17 3213109.191 369750682.1 62760928.78 31462881.14 6 15 16 14 cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding Pf00149 5499 ENSG00000172531.14 PPP1CA 11 Signaling by GPCR; Triglyceride catabolism; DARPP-32 events; Downregulation of TGF-beta receptor signaling; Circadian Clock Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation 15 High Q9BVP2 Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2 0 230.247 54 30 83 30 549 62 9.16 30 3 3 76 4 3 40424289.25 1090125231 11974195.07 7959249.959 11 30 10 11 cell division;cell proliferation;regulation of biological process membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf01926, Pf02421, Pf08701" 26354 ENSG00000163938.16 GNL3 3 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High Q5JTH9 RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2 0 284.085 46 45 82 45 1297 143.6 8.75 45 82 20568954.2 417671560.8 11910498.29 3501031.4 11 44 14 7 membrane;nucleus RNA binding Pf08161 23223 ENSG00000052749.13 RRP12 10 0 High Q14444 Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2 0 187.926 35 20 82 20 709 78.3 5.25 2 19 2 4 4 69 4 5 2106800.625 996630646.1 26961774.09 24780887.84 3 23 9 10 Met-loss [N-Term] cell differentiation;regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding Pf12287 4076 ENSG00000135387.20 CAPRIN1 11 0 High P42766 60S ribosomal protein L35 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2 0 61.376 44 10 81 10 123 14.5 11.05 2 10 5 5 4 56 12 9 3669234.67 3746205860 61300119.59 34847711.91 3 11 6 7 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf00831 11224 ENSG00000136942.14 RPL35 9 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9NVP1 ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2 0 238.624 63 35 80 35 670 75.4 9.5 34 2 1 77 2 1 1530596.227 515356652.3 16212157.98 12608225.03 4 35 14 11 metabolic process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851, Pf13959" 8886 ENSG00000088205.12 DDX18 2 0 High Q9H0D6 5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1 0 259.36 56 43 80 43 950 108.5 7.47 43 3 1 76 3 1 1707471.383 497715007.4 11534128.4 6368123.31 7 40 9 15 Met-loss [N-Term] cell differentiation;metabolic process;regulation of biological process membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding Pf03159 22803 ENSG00000088930.7 XRN2 20 Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis Ribosome biogenesis in eukaryotes; RNA degradation 0 High P15924 Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3 0 102.622 14 42 79 42 2871 331.6 6.81 28 2 9 21 43 2 10 24 28474893.73 452401220.8 23459886.28 22335874.41 28 16 18 24 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity "Pf00038, Pf00681, Pf01540, Pf01576, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06008, Pf06160, Pf06637, Pf07888, Pf10174, Pf12072, Pf12128, Pf13166" 1832 ENSG00000096696.13 DSP 6 Apoptotic cleavage of cell adhesion proteins; Formation of the cornified envelope; Neutrophil degranulation Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0 High O00425 Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2 0 173.227 53 27 79 22 579 63.7 8.87 26 4 6 67 5 7 557147242.9 7552268.09 9578273.9 22 8 11 metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;translation regulator activity "Pf00013, Pf00076, Pf13014, Pf13893, Pf14259, Pf14611" 10643 ENSG00000136231.13 IGF2BP3 7 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 1 High Q92522 Histone H1x OS=Homo sapiens OX=9606 GN=H1FX PE=1 SV=1 0 101.795 65 19 79 19 213 22.5 10.76 1 19 3 2 1 70 4 4 154218615.7 2210188480 29447653.54 23273591.83 4 22 6 7 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 8971 ENSG00000184897.5 H1FX 3 0 High Q96SB4 SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2 0 210.105 46 30 79 26 655 74.3 6.16 30 1 3 75 1 3 9078064.194 596992360.8 188553162.8 124767043.6 8 32 8 12 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00069, Pf07714" 6732 ENSG00000096063.15 SRPK1 6 Herpes simplex infection 5 High O75533 Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3 0 324.924 55 51 78 51 1304 145.7 7.09 1 48 4 1 1 72 4 1 4847543.434 260967206.6 11470857.5 8580300.955 8 46 12 11 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex DNA binding;protein binding;receptor activity;RNA binding;signal transducer activity "Pf02161, Pf08920, Pf12815, Pf13513" 23451 ENSG00000115524.15 SF3B1 2 B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9BQ39 ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1 0 262.681 63 37 77 35 737 82.5 9.17 37 3 2 71 4 2 4614178.875 385173104.1 6795348.872 10428431.6 6 31 9 14 metabolic process cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf04851, Pf08152, Pf14617" 79009 ENSG00000107625.12 DDX50 10 0 High Q9Y3U8 60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3 0 65.153 34 6 77 6 105 12.2 11.59 3 6 6 5 6 48 15 8 11918811.44 2954030360 105367953.8 32843213.79 5 10 7 7 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01158 25873 ENSG00000130255.12 RPL36 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9H6S0 3'-5' RNA helicase YTHDC2 OS=Homo sapiens OX=9606 GN=YTHDC2 PE=1 SV=2 0 255.295 39 44 77 44 1430 160.1 8.4 44 2 74 3 6613593.122 328350149 14965093.53 5200744.672 8 40 13 7 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00271, Pf01424, Pf04146, Pf04408, Pf07717, Pf12796, Pf13637, Pf13857" 64848 ENSG00000047188.15 YTHDC2 5 0 High P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2 0 164.91 48 35 77 35 812 89.2 9.23 1 34 6 2 1 67 7 2 2713956.129 3964961692 20233621.12 4978918.178 5 35 10 13 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;protein binding;RNA binding "Pf01189, Pf12847" 4839 ENSG00000111641.11 NOP2 12 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; rRNA modification in the nucleus and cytosol 0 High P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1 0 148.944 69 18 77 4 323 37 6.54 1 17 9 9 1 42 21 13 384295.4375 72178039.5 5388048.125 1603118.625 1 4 2 2 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;protein binding;RNA binding Pf00149 5501 ENSG00000186298.11 PPP1CC 12 Triglyceride catabolism; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Downregulation of TGF-beta receptor signaling; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Circadian Clock Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation 0 High O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3 0 116.372 32 29 76 29 1046 116.9 6.7 2 21 23 2 36 38 135445.625 69137258.59 68830362.69 58978353.02 1 13 24 27 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf00515, Pf04184, Pf07719, Pf13176, Pf13181, Pf13374, Pf13414, Pf13424, Pf13428, Pf13429, Pf13431, Pf13432, Pf13844, Pf14559" 8473 ENSG00000147162.13 OGT X HATs acetylate histones; UCH proteinases Other types of O-glycan biosynthesis; Insulin resistance 0 High Q9NW13 RNA-binding protein 28 OS=Homo sapiens OX=9606 GN=RBM28 PE=1 SV=3 0 198.185 48 35 76 35 759 85.7 9.22 34 4 1 70 5 1 4121557.25 485994547.4 11936500.34 6066664.492 6 33 7 9 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 55131 ENSG00000106344.8 RBM28 7 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9UN86 Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2 0 187.225 49 19 75 18 482 54.1 5.55 18 4 3 66 6 3 646337.5664 520821296.1 6152470.516 4013356.897 3 21 7 11 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol protein binding;RNA binding;structural molecule activity "Pf00076, Pf02136, Pf14259" 9908 ENSG00000138757.14 G3BP2 4 0 High Q14694 Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2 0 192.59 48 28 75 28 798 87.1 5.31 28 75 3661185.828 503110283.5 7565898.031 12848636.61 4 29 4 8 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;nucleus catalytic activity;protein binding;RNA binding "Pf00443, Pf13423" 9100 ENSG00000103194.15 USP10 16 Termination of translesion DNA synthesis; Ub-specific processing proteases 0 High Q9Y4P3 Transducin beta-like protein 2 OS=Homo sapiens OX=9606 GN=TBL2 PE=1 SV=1 0 249.739 67 34 74 34 447 49.8 9.44 34 1 1 72 1 1 565438.0508 567043527 3710515.781 4554952.189 3 35 7 9 cell communication;regulation of biological process;response to stimulus endoplasmic reticulum protein binding;RNA binding Pf00400 26608 ENSG00000106638.15 TBL2 7 0 High Q7Z794 "Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=2 SV=3" 0 21.59 6 4 74 1 578 61.9 5.99 3 4 3 3 26 11 18 19 111949248.8 197044237 101544008 1 1 1 cell death;cell organization and biogenesis cytoskeleton;cytosol structural molecule activity "Pf00038, Pf03962, Pf13166, Pf14817" 374454 ENSG00000189182.9 KRT77 12 Formation of the cornified envelope 0 High P01024 Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2 0 58.895 10 13 74 13 1663 187 6.4 10 11 11 17 30 27 7082219.266 120555828.2 399332802.9 298858009.4 5 12 12 12 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen catalytic activity;enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974" 718 ENSG00000125730.16 C3 19 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Alternative complement activation; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; G alpha (i) signalling events Viral carcinogenesis; Chagas disease (American trypanosomiasis); Leishmaniasis; Tuberculosis; Pertussis; Phagosome; Complement and coagulation cascades; Systemic lupus erythematosus; Herpes simplex infection; Staphylococcus aureus infection; Legionellosis 0 High Q7L0Y3 tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2 0 191.013 66 27 74 27 403 47.3 9.36 1 27 1 1 1 70 2 1 4879999.695 825345633.8 5565399.484 4773435.282 10 28 6 6 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding Pf01746 54931 ENSG00000174173.6 TRMT10C 3 tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA modification in the mitochondrion 0 High P62854 40S ribosomal protein S26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3 0 50.927 52 6 74 6 115 13 11 2 6 4 4 4 59 7 4 8463598.375 3492313764 55158399 17345420.19 3 7 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01283 6231; 101929876; 728937 ENSG00000197728.9 RPS26; LOC101929876; RPS26P25 12; 20; 4 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P17066 Heat shock 70 kDa protein 6 OS=Homo sapiens OX=9606 GN=HSPA6 PE=1 SV=2 0 66.745 16 11 73 1 643 71 6.14 6 6 11 8 13 11 24 25 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00012, Pf06723" 3310 ENSG00000173110.7 HSPA6 1 Neutrophil degranulation; Regulation of HSF1-mediated heat shock response Endocytosis; Longevity regulating pathway - multiple species; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 0 High P22061 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4 0 78.81 69 15 73 15 227 24.6 7.21 11 1 12 13 23 1 21 28 45456151.91 7593043.225 117899192.9 104904620.6 15 7 16 16 metabolic process cytoplasm;cytosol catalytic activity;protein binding "Pf01135, Pf01209, Pf05175, Pf06325, Pf08241, Pf12847, Pf13489, Pf13659, Pf13847" 5110 PCMT1 6 Protein repair 0 High Q8IWS0 PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1 0 164.282 67 23 72 23 365 41.3 8.68 23 3 1 68 3 1 1563955.469 752966229.8 8025827.125 7351898.375 3 27 11 8 metabolic process;regulation of biological process chromosome;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf13771, Pf13832" 84295 ENSG00000156531.16 PHF6 X 0 High P60866 40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1 0 58.875 54 8 72 8 119 13.4 9.94 2 8 5 4 5 52 9 6 4517962.25 2556892897 37433415.47 18920655.83 2 8 6 6 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00338 6224 ENSG00000008988.9 RPS20 8 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q9BZE4 Nucleolar GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP4 PE=1 SV=3 0 201.938 58 33 72 33 634 73.9 9.5 1 31 6 2 1 63 6 2 3538745.579 429467304.8 14205293.38 20485887.16 5 31 15 14 Met-loss+Acetyl [N-Term] cell differentiation;regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf01926, Pf02421, Pf06858, Pf08155, Pf08477" 23560 ENSG00000107937.18 GTPBP4 10 Ribosome biogenesis in eukaryotes 0 High P62851 40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1 0 38.55 47 9 71 9 125 13.7 10.11 3 9 4 4 5 45 14 7 10164311.68 3367086660 68665566.06 32692819.87 5 11 6 6 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity Pf03297 6230 ENSG00000280831.2; ENSG00000118181.10 RPS25 11; CHR_HG2217_PATCH "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q96DT7 Zinc finger and BTB domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZBTB10 PE=1 SV=2 0 132.128 47 26 71 26 871 94.8 5.16 2 18 21 2 33 36 8006047.5 77550400.55 78151276.41 84824004.97 4 10 18 19 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465" 65986 ENSG00000205189.11 ZBTB10 8 0 High P55265 Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4 0 233.232 39 42 71 42 1226 136 8.65 42 3 68 3 11333796.93 367376335.3 9774259.719 10871422.86 7 39 9 14 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00035, Pf02137, Pf02295" 103 ENSG00000160710.15 ADAR 1 C6 deamination of adenosine; Interferon alpha/beta signaling; Formation of editosomes by ADAR proteins Cytosolic DNA-sensing pathway; Measles; Influenza A 0 High Q9BUF5 Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1 0 66.872 21 10 70 2 446 49.8 4.88 5 6 7 9 6 17 21 26 2132718 1249864.406 1 2 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 84617 ENSG00000176014.12 TUBB6 18 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 0 High P49207 60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3 0 28.712 44 8 70 8 117 13.3 11.47 4 8 6 5 9 42 11 8 16485511.92 3707120356 91432497.5 32034668.64 3 10 6 7 cell organization and biogenesis;metabolic process;transport cytosol;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf01199 6164 ENSG00000109475.16 RPL34 4 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q5UIP0 Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2 0 172.835 21 39 70 39 2472 274.3 5.52 1 23 34 1 28 41 912328.8557 20900273.5 60843413.36 60465453.75 5 10 27 32 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;membrane;nucleus protein binding Pf12231 55183 ENSG00000080345.17 RIF1 2 Nonhomologous End-Joining (NHEJ) Signaling pathways regulating pluripotency of stem cells 0 High Q5BKY9 Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1 0 47.001 31 9 70 9 247 28.4 10.02 8 5 7 9 22 7 18 23 100125812.6 1029031620 260257452.7 163030512.8 9 6 9 10 RNA binding 257415 ENSG00000234545.7 FAM133B 7 0 High P46776 60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2 0 83.514 46 10 69 10 148 16.6 11 2 10 3 4 3 49 8 9 9188514.373 4486788319 76421966.5 34368376.61 5 12 4 5 cell organization and biogenesis;metabolic process;transport cytosol;endoplasmic reticulum;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00828 6157 ENSG00000166441.12 RPL27A 11 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P01892 "HLA class I histocompatibility antigen, A-2 alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=1" 0 142.213 63 22 69 16 365 40.9 6.99 1 1 5 22 1 2 8 58 2642804.634 99268968.81 18836880.33 309463220.1 5 7 10 20 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;Golgi;membrane protein binding;RNA binding "Pf00129, Pf07654" 3105; 100507703 ENSG00000235657.9 HLA-A; LOC100507703 6; CHR_HSCHR6_MHC_DBB_CTG1 "Interferon alpha/beta signaling; E3 ubiquitin ligases ubiquitinate target proteins; Endosomal/Vacuolar pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway; Nef mediated downregulation of MHC class I complex cell surface expression" 6 High P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3 0 120.725 54 16 69 4 327 37.2 6.19 1 16 8 7 1 39 18 11 66723244.5 7495582 2519202.594 4 2 3 Met-loss+Acetyl [N-Term] cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding Pf00149 5500 ENSG00000213639.9 PPP1CB 2 Triglyceride catabolism; RHO GTPases activate PAKs; RHO GTPases Activate ROCKs; Regulation of PLK1 Activity at G2/M Transition; Downregulation of TGF-beta receptor signaling; RHO GTPases activate CIT; RHO GTPases activate PKNs; Circadian Clock Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation 0 High Q13263 Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5 0 229.308 51 27 68 27 835 88.5 5.77 24 12 6 47 14 7 501238837.1 224268966.2 24071649.06 10535881.11 5 27 13 13 Met-loss+Acetyl [N-Term] cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00628, Pf00643" 10155 ENSG00000130726.11 TRIM28 19 Generic Transcription Pathway 0 High Q13823 Nucleolar GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=GNL2 PE=1 SV=1 0 225.336 47 37 68 37 731 83.6 9.25 37 1 67 1 988699.9922 518380252.8 43710721.08 21249452.53 4 37 11 14 membrane;nucleus catalytic activity;nucleotide binding;RNA binding "Pf01926, Pf08153" 29889 ENSG00000134697.12 GNL2 1 Ribosome biogenesis in eukaryotes 0 High Q12789 General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4 0 206.493 25 42 67 42 2109 238.7 7.3 42 1 66 1 1696541.797 219821656.1 12074242.16 7250429.914 4 38 6 13 metabolic process;regulation of biological process membrane;nucleus DNA binding;protein binding Pf04182 2975 ENSG00000077235.17 GTF3C1 16 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 High P10321 "HLA class I histocompatibility antigen, Cw-7 alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3" 0 149.639 56 18 67 7 366 40.6 6.04 1 3 4 18 1 5 7 54 926869.7266 23155720.14 11284921.22 231539066.2 3 4 5 13 regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;Golgi;membrane protein binding "Pf00129, Pf07654" 3107 ENSG00000204525.16 HLA-C 6 "Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity; HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation 6 High O14497 AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3 0 132.295 22 31 67 29 2285 241.9 6.7 8 18 23 12 27 28 12355460.08 55801743.09 25558531.13 25273588.41 9 7 19 25 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus DNA binding;protein binding "Pf01388, Pf12031" 8289 ENSG00000117713.18 ARID1A 1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 2 High P62847 40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1 0 82.549 36 6 66 6 133 15.4 10.78 2 6 4 3 3 52 5 6 2133666.125 1641501121 19730567.08 12256599 4 12 4 7 Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01282 6229 ENSG00000138326.18 RPS24 10 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q96HS1 "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" 0 112.161 55 16 66 16 289 32 8.68 6 15 8 8 7 37 10 12 4637354.219 248183544.6 36073744.78 19928845.83 8 16 12 12 cell communication;cell death;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding;signal transducer activity Pf00300 192111 ENSG00000247077.6 PGAM5 12 TNF signaling pathway 0 High Q99575 Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2 0 239.464 45 34 66 34 1024 114.6 9.22 34 1 65 1 9139610.321 338991021 24164364.59 21904404.97 9 33 7 12 metabolic process Golgi;mitochondrion;nucleus catalytic activity;protein binding;RNA binding "Pf06978, Pf08170" 10940 ENSG00000104356.10 POP1 8 tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High P25705 "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" 0 80.808 43 20 65 20 553 59.7 9.13 3 7 12 18 3 11 19 32 1645605.563 250147449.9 1547074392 2290578437 3 12 14 19 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00006, Pf00306, Pf02663, Pf02874, Pf05943" 498 ENSG00000152234.15 ATP5A1 18 Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High P22087 rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2 0 172.147 66 20 65 20 321 33.8 10.18 2 20 5 3 2 52 8 3 2228879.383 459571360.5 17306688.94 5934319.688 6 21 8 5 cell differentiation;cell organization and biogenesis;metabolic process chromosome;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf01135, Pf01269, Pf13847" 2091 ENSG00000280548.3; ENSG00000105202.8 FBL 19; CHR_HG2021_PATCH Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P63208 S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2 0 97.266 77 14 65 14 163 18.6 4.54 5 14 11 8 34 23 515587.1484 73054345.43 237574436.6 132264013.9 2 7 12 12 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf01466, Pf03931" 6500 ENSG00000113558.18 SKP1 5 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Vpu mediated degradation of CD4; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; Oocyte meiosis; Circadian rhythm; Herpes simplex infection; Cell cycle 0 High P10809 "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" 0 107.672 40 22 64 22 573 61 5.87 3 9 16 14 3 11 27 23 4058387.359 1245183165 71471182.11 49054492.49 7 17 19 21 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endosome;membrane;mitochondrion;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding Pf00118 3329 ENSG00000144381.16 HSPD1 2 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Mitochondrial protein import; Metabolism of proteins Type I diabetes mellitus; Tuberculosis; RNA degradation; Legionellosis 0 High Q9UKT8 F-box/WD repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=FBXW2 PE=1 SV=2 0 95.175 44 17 64 17 454 51.5 6.58 14 16 30 34 265214.6211 51517521.28 88957049.88 86367193.53 2 7 17 16 metabolic process cytosol catalytic activity;protein binding Pf00400 26190 ENSG00000119402.16 FBXW2 9 Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High P84103 Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1 0 103.499 50 12 64 11 164 19.3 11.65 12 5 2 55 6 3 1391827.906 825969016.3 19078600.73 9152222.333 2 20 10 8 metabolic process;regulation of biological process;transport cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6428 ENSG00000112081.16 SRSF3 6 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 1 High Q8IY37 Probable ATP-dependent RNA helicase DHX37 OS=Homo sapiens OX=9606 GN=DHX37 PE=1 SV=1 0 195.793 41 37 64 37 1157 129.5 8.1 37 64 15999718.28 328213493.7 4493518.072 3990186.146 6 36 10 10 metabolic process cytoplasm catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717, Pf13401" 57647 ENSG00000150990.7 DHX37 12 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High O00567 Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4 0 183.154 56 26 64 26 594 66 9.19 26 5 5 53 5 6 12633547.44 351837422.9 11804432.66 6364768.516 4 26 10 7 metabolic process cytoplasm;membrane;nucleus protein binding;RNA binding "Pf01798, Pf08060, Pf08156" 10528 ENSG00000101361.16 NOP56 20 Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P05198 Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3 0 163.13 73 27 63 27 315 36.1 5.08 27 2 2 59 2 2 4734399.859 1166242382 8711224.852 14274896.96 5 29 8 10 cell communication;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding "Pf00575, Pf07541" 1965 ENSG00000134001.12 EIF2S1 14 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; PERK regulates gene expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition" Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease (NAFLD); RNA transport; Measles; Herpes simplex infection; Hepatitis C; Influenza A 0 High Q9GZR7 ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1 0 193.608 55 32 63 32 859 96.3 9.06 32 1 1 61 1 1 1899625.813 252437227.4 4802036.125 6020425.843 4 31 7 10 metabolic process cytoplasm;membrane catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf13307" 57062 ENSG00000273761.5; ENSG00000089737.16 DDX24 14; CHR_HSCHR14_7_CTG1 0 High P47914 60S ribosomal protein L29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2 0 51.848 43 10 63 10 159 17.7 11.66 1 10 4 2 3 52 5 3 8373673.493 2715701199 41788823.27 21115399.5 3 17 5 7 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01779 6159 ENSG00000162244.10 RPL29 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8TDN6 Ribosome biogenesis protein BRX1 homolog OS=Homo sapiens OX=9606 GN=BRIX1 PE=1 SV=2 0 175.527 71 22 62 22 353 41.4 9.92 22 3 3 55 4 3 226309.4922 489379184.9 8651201.344 5079649.276 1 20 6 9 cell organization and biogenesis nucleus RNA binding Pf04427 55299 ENSG00000113460.12 BRIX1 5 0 High Q13151 Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1 0 133.229 61 15 62 14 305 30.8 9.29 2 15 2 3 2 54 2 4 3253008.813 731251976.2 28779322.78 21647638.72 3 15 5 9 Acetyl [N-Term] defense response;metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10949 ENSG00000177733.6 HNRNPA0 5 mRNA Splicing - Major Pathway 0 High O60841 Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4 0 234.268 31 32 62 32 1220 138.7 5.49 32 62 724908.625 266009508.7 6536724.771 1248168.727 1 27 6 10 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00009, Pf01926, Pf03144, Pf11987, Pf14578" 9669 ENSG00000158417.10 EIF5B 2 GTP hydrolysis and joining of the 60S ribosomal subunit RNA transport 0 High Q5QNW6 Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=HIST2H2BF PE=1 SV=3 0 42.378 53 8 61 3 126 13.9 10.32 6 7 7 5 9 32 12 8 27019406.7 2235813901 179547974.4 63990024.16 6 8 8 6 cell organization and biogenesis chromosome;cytosol;nucleus DNA binding;protein binding "Pf00125, Pf00808" 440689 ENSG00000203814.6 HIST2H2BF 1 HDACs deacetylate histones; HATs acetylate histones; Ub-specific processing proteases Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 6 High O75534 Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2 0 185.038 42 29 61 29 798 88.8 6.25 28 3 58 3 3189101.388 574727128.6 24600182.89 18261448.57 6 29 9 8 metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;membrane DNA binding;protein binding;RNA binding "Pf00313, Pf12901" 7812 ENSG00000009307.15 CSDE1 1 0 High P49411 "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2" 0 119.288 48 17 61 17 452 49.5 7.61 12 11 11 21 20 20 4760299.453 112843320.6 63120173.41 48038813.02 3 12 12 13 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 7284 TUFM 16 Mitochondrial translation elongation 0 High P78406 mRNA export factor OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1 0 105.598 45 15 61 15 368 40.9 7.83 12 12 11 18 22 21 2779693.063 58302023.75 563534830.2 574815354.4 3 13 14 14 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;nucleus protein binding;RNA binding Pf00400 8480 ENSG00000101146.12 RAE1 20 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport; Influenza A 0 High P20042 Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2 0 158.431 61 24 61 24 333 38.4 5.8 24 1 59 2 1308908.273 682326130.8 3016427.813 2969992.496 3 23 4 6 cell proliferation;metabolic process;transport cytoplasm;cytosol;nucleus metal ion binding;protein binding;RNA binding "Pf01873, Pf04147" 8894 ENSG00000125977.6 EIF2S2 20 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition" RNA transport 0 High P62899 60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1 0 67.613 55 13 61 13 125 14.5 10.54 2 13 4 2 5 47 6 3 8910317.77 4016638219 37385154.88 23641003.67 6 14 8 8 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01198 6160 ENSG00000071082.10 RPL31 2 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9UKB1 F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1 0 104.21 50 24 61 16 542 62.1 7.12 6 15 21 6 28 27 6799056.716 233774902.5 119481857.9 85656814.3 4 13 21 23 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00400, Pf00646, Pf08801, Pf12125, Pf12937" 23291 ENSG00000072803.17 FBXW11 5 Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Neddylation; Activated TLR4 signalling; Interleukin-1 family signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling Ubiquitin mediated proteolysis; Hippo signaling pathway; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Shigellosis 8 High Q2NL82 Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1 0 182.221 41 27 60 27 804 91.8 7.42 27 1 59 1 15849856.21 382822164.5 913254.5938 2394220.484 8 24 2 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytosol;nucleus catalytic activity;nucleotide binding;RNA binding "Pf04950, Pf08142" 55720 ENSG00000167721.10 TSR1 17 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q7Z2W4 Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3 0 212.194 49 31 60 31 902 101.4 8.4 31 1 59 1 5819108.961 256589401.6 8451822.941 16726876.06 5 28 8 8 Met-loss+Acetyl [N-Term] defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00644 56829 ENSG00000105939.12 ZC3HAV1 7 Signaling by BRAF and RAF fusions 0 High P47897 Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS PE=1 SV=1 0 179.351 56 36 60 35 775 87.7 7.15 4 35 3 2 4 51 3 2 2697863.555 294513920.4 6144745.719 11293210.35 9 33 7 9 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;organelle lumen catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00749, Pf03950, Pf04557, Pf04558" 5859 ENSG00000172053.17 QARS 3 Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis; Metabolic pathways 0 High Q8N257 Histone H2B type 3-B OS=Homo sapiens OX=9606 GN=HIST3H2BB PE=1 SV=3 0 43.893 53 8 59 3 126 13.9 10.32 5 7 7 5 8 32 12 7 2014972.625 270209511 11847679.61 4159766.908 1 3 2 3 cell organization and biogenesis chromosome;cytosol;nucleus DNA binding;protein binding "Pf00125, Pf00808" 128312 ENSG00000196890.4 HIST3H2BB 1 SIRT1 negatively regulates rRNA expression; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 0 High Q96SI9 Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1 0 155.156 42 27 59 21 672 73.6 8.72 27 1 58 1 1245888.438 128259181.5 2703020.484 3421140.266 4 20 3 5 cell differentiation;development;response to stimulus cytoplasm;cytoskeleton;nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf07528, Pf14709" 55342 ENSG00000165209.18 STRBP 9 0 High Q99567 Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2 0 103.898 42 26 59 26 741 83.5 5.69 1 16 23 1 27 31 818105.1394 71895394.41 61673535.03 54268329.16 4 11 21 25 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytosol;nucleus protein binding;transporter activity "Pf02050, Pf07767, Pf09789, Pf10168" 4927 ENSG00000108559.11 NUP88 17 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P49711 Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1 0 199.573 41 24 59 24 727 82.7 6.96 24 59 9164.083984 297268872.6 2232458.172 1158107.478 1 26 7 5 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;metal ion binding;protein binding "Pf06750, Pf13465" 10664 ENSG00000102974.14 CTCF 16 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0 High O00411 "DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2" 0 286.324 49 36 59 36 1230 138.5 8.98 36 59 54264462.98 233948319.2 812414.8789 598466.5652 7 37 5 6 cell organization and biogenesis;metabolic process mitochondrion;organelle lumen catalytic activity;DNA binding;protein binding;RNA binding "Pf00940, Pf14700" 5442 ENSG00000099821.13 POLRMT 19 Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis 0 High P08865 40S ribosomal protein SA OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4 0 182.085 64 17 59 17 295 32.8 4.87 1 17 4 1 1 52 5 1 1656719.438 1310392439 8892785.375 4403931.173 4 18 6 9 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;receptor activity;RNA binding;structural molecule activity Pf00318 3921 ENSG00000168028.13 RPSA 3 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q13435 Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2 0 174.169 45 32 58 32 895 100.2 5.67 31 3 1 53 4 1 6195521.047 1302349570 530375401.1 625276170.6 3 30 9 12 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf02037, Pf04037, Pf04046" 10992 ENSG00000087365.15 SF3B2 11 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q5T3I0 G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2 0 168.045 62 29 58 29 446 50.4 9.63 29 1 57 1 1410644.977 418791647.3 4212885.813 1256654.203 5 28 3 4 Acetyl [N-Term] protein binding;RNA binding Pf01585 54865 GPATCH4 1 0 High Q15424 Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4 0 100.469 21 17 58 10 915 102.6 5.47 9 3 11 15 13 3 19 23 8504866.578 98852925.39 44270814.7 37506228.12 10 10 16 18 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 6294 ENSG00000160633.12 SAFB 19 9 High Q9UG63 ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2 0 144.902 40 23 57 23 623 71.2 7.37 23 4 1 51 5 1 494707.125 314923701.6 4623261.688 1917504.019 1 23 5 5 transport membrane;mitochondrion catalytic activity;nucleotide binding;transporter activity "Pf00005, Pf12848" 10061 ENSG00000033050.7 ABCF2 7 0 High Q9NQ29 Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1 0 99.015 37 13 57 6 371 43.7 9.92 4 12 6 4 7 37 7 6 775954.9375 75804067 4650598.375 8713622.25 2 7 2 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding Pf03194 55692 ENSG00000007392.16 LUC7L 16 0 High P35268 60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2 0 84.54 69 10 57 9 128 14.8 9.19 2 10 3 2 2 45 6 4 17909938.31 3071692873 49728623.43 19644907.75 6 12 3 5 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01776 6146 ENSG00000116251.9 RPL22 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 1 High P38159 "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" 0 87.298 50 22 57 22 391 42.3 10.05 1 22 3 5 1 44 5 7 1623675.168 358287967.2 17306847.59 11868354.13 2 22 7 7 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf08081, Pf13893, Pf14259" 27316 ENSG00000147274.14 RBMX X mRNA Splicing - Major Pathway Spliceosome 0 High P63104 14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 GN=YWHAZ PE=1 SV=1 0 74.96 60 13 57 9 245 27.7 4.79 1 8 13 11 1 11 21 24 10682810.54 24258689.22 54239501.13 37702572.55 6 7 11 10 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding Pf00244 7534 ENSG00000164924.17 YWHAZ 8 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Interleukin-3, 5 and GM-CSF signaling; KSRP (KHSRP) binds and destabilizes mRNA; Activation of BAD and translocation to mitochondria ; GP1b-IX-V activation signalling; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs" Viral carcinogenesis; Pathogenic Escherichia coli infection; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 0 High P62805 Histone H4 OS=Homo sapiens OX=9606 GN=HIST1H4A PE=1 SV=2 0 57.921 53 9 56 9 103 11.4 11.36 4 9 6 6 4 24 15 13 5693046.191 1412017754 108631936.8 51503159.5 3 9 7 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00125, Pf02969, Pf15630" 8359; 8361; 8360; 8363; 8370; 554313; 8365; 8364; 121504; 8367; 8294; 8366; 8362; 8368 ENSG00000197061.4; ENSG00000275126.1; ENSG00000273542.1; ENSG00000197238.4; ENSG00000197837.3; ENSG00000276966.2; ENSG00000158406.4; ENSG00000270882.2; ENSG00000274618.1; ENSG00000278637.1; ENSG00000277157.1; ENSG00000278705.1; ENSG00000270276.2; ENSG00000276180.1 HIST1H4A; HIST1H4F; HIST1H4D; HIST1H4J; HIST2H4A; HIST2H4B; HIST1H4H; HIST1H4C; HIST4H4; HIST1H4E; HIST1H4I; HIST1H4B; HIST1H4K; HIST1H4L 6; 1; 12 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of chromatin organization proteins; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 0 High P17480 Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1 0 149.346 38 27 56 27 764 89.4 5.81 27 1 54 2 1805718.454 267315227.1 6640172624 5238428503 8 26 10 13 metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf00505, Pf09011, Pf14887" 7343 ENSG00000108312.14 UBTF 17 RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; RNA Polymerase I Promoter Opening; RNA Polymerase I Transcription Initiation 0 High O60762 Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=DPM1 PE=1 SV=1 0 81.532 62 17 56 17 260 29.6 9.57 3 13 12 3 27 26 2810931.317 37457705.17 119892874.8 141302726.6 6 11 18 19 Met-loss+Acetyl [N-Term] metabolic process endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding "Pf00535, Pf10111, Pf13641, Pf13704, Pf13712" 8813 ENSG00000000419.12 DPM1 20 Defective DPM1 causes DPM1-CDG (CDG-1e); Synthesis of dolichyl-phosphate mannose N-Glycan biosynthesis; Metabolic pathways 0 High Q9UNX4 WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1 0 201.727 55 35 56 35 943 106 6.64 35 1 1 54 1 1 8490907.048 179302847.6 1829083.559 3363485.253 8 30 4 8 metabolic process membrane;nucleus protein binding;RNA binding "Pf00400, Pf04003" 10885 ENSG00000065183.15 WDR3 1 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q8IWR0 Zinc finger CCCH domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZC3H7A PE=1 SV=1 0 167.658 37 33 55 30 971 110.5 7.3 33 2 53 2 20355367.05 153001705.7 14303214.15 20091412.56 7 31 9 6 metabolic process;regulation of biological process;response to stimulus nucleus metal ion binding;protein binding;RNA binding "Pf00642, Pf12171, Pf13414" 29066 ENSG00000122299.11 ZC3H7A 16 3 High Q8NCA5 Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=1 0 121.077 47 16 55 13 519 55.4 9.03 1 16 5 5 1 43 5 6 6291969.172 860670676.1 46541887.46 19529261.15 3 16 8 8 Acetyl [N-Term] metabolic process;regulation of biological process catalytic activity;protein binding;RNA binding Pf10239 25940 FAM98A 2 3 High P26368 Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4 0 134.951 56 18 55 18 475 53.5 9.09 1 18 3 4 1 46 4 4 311568258.6 248442223.1 7727426.082 5198253.839 5 18 6 10 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;transport nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 11338 ENSG00000063244.12 U2AF2 19 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome 0 High P50402 Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1 0 80.13 62 12 55 12 254 29 5.5 2 8 7 11 3 16 14 22 706969.1826 61366868.57 111187265.4 98423036.36 3 10 11 12 Acetyl [N-Term] cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus protein binding Pf03020 2010 ENSG00000102119.10 EMD X Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM) 0 High Q66PJ3 ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=2 0 69.157 27 11 54 11 421 44.9 10.93 8 6 8 10 13 8 13 20 20795369.41 61786372.75 63408259.05 76865514.91 9 10 10 11 metabolic process nucleus protein binding;RNA binding Pf10500 51329 ENSG00000182196.13 ARL6IP4 12 0 High P56192 "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS PE=1 SV=2" 0 182.002 36 26 54 26 900 101.1 6.16 2 26 1 5 2 45 2 5 3285131.932 235212792.8 6874865.344 9840631.563 8 26 6 11 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00043, Pf00133, Pf00458, Pf09334, Pf10978, Pf13409, Pf13410, Pf14497" 4141 ENSG00000166986.14 MARS 12 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Selenocompound metabolism; Aminoacyl-tRNA biosynthesis 0 High Q86V81 THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3 0 154.31 57 13 53 13 257 26.9 11.15 13 4 2 47 4 2 1664313.97 1087023473 11639739.13 6951108.034 2 17 5 6 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10189 ALYREF 17 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Transport of the SLBP Dependant Mature mRNA; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA Spliceosome; mRNA surveillance pathway; RNA transport; Herpes simplex infection 0 High Q9H2G2 STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1 0 11.269 3 3 53 2 1235 142.6 5.15 1 3 1 1 15 8 15 15 2429854079 2201063937 3375293046 5771342015 1 3 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12474, Pf14531" 9748 ENSG00000065613.13 SLK 10 Oocyte meiosis 1 High Q13247 Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2 0 76.236 34 15 53 9 344 39.6 11.43 3 14 5 3 4 38 7 4 1975804.734 243107229.5 5843163.563 5747356.979 3 11 3 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 6431 ENSG00000124193.14 SRSF6 20 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 High Q9BQ67 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1 0 186.193 59 19 53 19 446 49.4 4.92 19 5 44 9 1949438.906 614456746 23418843.18 14528457.98 6 18 11 9 cell organization and biogenesis;metabolic process chromosome;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00400, Pf12265" 83743 ENSG00000105447.12 GRWD1 19 0 High Q9UPQ9 Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4 0 109.165 25 29 52 29 1833 193.9 6.76 9 2 9 26 10 2 11 29 5891891.247 15887513.19 16784088.94 36155939.43 7 6 12 23 regulation of biological process;response to stimulus cytoplasm;cytosol protein binding;RNA binding "Pf10427, Pf13893" 23112 ENSG00000100354.20 TNRC6B 22 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High Q8TA86 Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2 0 47.998 49 12 52 12 221 26.1 9.79 9 2 6 9 20 2 12 18 2057547966 101960647.8 3822896119 4249528198 10 5 8 11 Met-loss+Acetyl [N-Term] metabolic process cytosol;nucleus metal ion binding;protein binding;RNA binding 6100 ENSG00000164610.8 RP9 7 Spliceosome 0 High O00139 Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3 0 160.942 53 30 52 28 706 79.9 6.68 30 1 50 2 284705.2969 257104557.9 32639200.77 11211634.97 3 29 5 9 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;development;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding Pf00225 3796 ENSG00000068796.16 KIF2A 5 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation 2 High Q13610 Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1 0 149.946 47 18 52 18 501 55.8 4.77 18 4 1 47 4 1 2452370473 349506566 6167890.738 1136180.273 6 18 6 5 cell organization and biogenesis;metabolic process;regulation of biological process Golgi;nucleus protein binding Pf00400 11137 ENSG00000136045.11 PWP1 12 0 High P62979 Ubiquitin-40S ribosomal protein S27a OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2 0 85.796 53 8 52 4 156 18 9.64 1 5 5 4 2 35 10 5 816419.875 1127904294 26997421.91 14296499 2 8 9 6 cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00240, Pf01599, Pf11976, Pf13019, Pf13881, Pf14560" 6233 ENSG00000143947.13 RPS27A 2 "NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Formation of the ternary complex, and subsequently, the 43S complex; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; Ribosomal scanning and start codon recognition; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits" Ribosome 5 High Q7Z2T5 TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2 0 164.516 51 27 52 27 733 81.7 7.88 27 1 1 50 1 1 7432331.656 214248322.6 15162381.96 3993545.964 4 25 5 11 Acetyl [N-Term] metabolic process;response to stimulus catalytic activity;metal ion binding;RNA binding "Pf02005, Pf02475" 81627 ENSG00000121486.11 TRMT1L 1 0 High Q9NUD5 Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2 0 137.971 51 18 51 18 403 43.5 8.53 18 3 4 44 3 4 4539330.664 301896926 4404773.688 4917210.092 4 18 6 7 0 High Q5SSJ5 Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1 0 134.065 42 24 51 24 553 61.2 9.67 24 51 4887300.782 493544481.9 1977308.383 1304157.4 7 25 3 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf00538 50809 ENSG00000127483.17 HP1BP3 1 0 High P42167 "Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" 0 81.594 46 16 51 8 454 50.6 9.38 1 7 8 13 1 10 15 25 549019.1875 43805652.88 51135669.23 40268481.37 3 9 13 15 Met-loss [N-Term] regulation of biological process chromosome;cytoplasm;membrane;nucleus DNA binding;protein binding "Pf03020, Pf08198" 7112 ENSG00000120802.13 TMPO 12 Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 9 High O00178 GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3 0 203.449 58 23 51 23 669 72.4 8.34 23 51 2971957.875 296030280.6 24789259.17 19636103.18 2 27 9 8 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;RNA binding "Pf00009, Pf03143, Pf03144" 9567 ENSG00000100226.15 GTPBP1 22 0 High Q07666 "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" 0 111.937 41 17 51 17 443 48.2 8.66 2 17 3 3 3 41 3 4 3856577.25 568878461.3 8313683.813 5519775.684 3 18 6 6 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 10657 ENSG00000121774.17 KHDRBS1 1 PTK6 Regulates Proteins Involved in RNA Processing 0 High P27348 14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1 0 73.223 63 16 50 11 245 27.7 4.78 1 5 15 11 1 8 22 19 594799.4053 49354322.72 78042222.38 58145605.9 3 5 13 13 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion protein binding Pf00244 10971 ENSG00000134308.13 YWHAQ 2 Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs Viral carcinogenesis; Pathogenic Escherichia coli infection; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 3 High P07910 Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4 0 67.521 39 15 50 14 306 33.7 5.08 5 13 5 5 6 29 7 8 8274169.516 255589631.9 16866157.75 12345968.28 5 13 7 9 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoskeleton;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3183 ENSG00000092199.17 HNRNPC 14 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Spliceosome 1 High P42677 40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3 0 50.706 42 6 50 3 84 9.5 9.45 3 6 3 4 5 26 9 10 6311889.844 1027217440 32792493.73 42969483.03 6 8 7 7 cell organization and biogenesis;cell proliferation;metabolic process;transport cytosol;nucleus;ribosome DNA binding;metal ion binding;protein binding;RNA binding;structural molecule activity Pf01667 6232 ENSG00000177954.11 RPS27 1 "Peptide chain elongation; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Separation of Sister Chromatids; SRP-dependent cotranslational protein targeting to membrane; Eukaryotic Translation Termination; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Major pathway of rRNA processing in the nucleolus and cytosol; RHO GTPases Activate Formins; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits" Ribosome 5 High Q15393 Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4 0 131.624 26 25 50 25 1217 135.5 5.26 2 24 2 2 2 44 2 2 4137548.367 174885950.6 2369287.787 2793803.752 9 24 5 6 cell organization and biogenesis;metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf03178, Pf10433" 23450 ENSG00000189091.12 SF3B3 16 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High P26196 Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2 0 165.605 54 21 49 21 483 54.4 8.66 1 21 4 1 1 43 4 1 463877.4688 197002490.4 31122985.34 18704188 2 21 8 11 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf14617" 1656 ENSG00000110367.11 DDX6 11 mRNA decay by 5' to 3' exoribonuclease RNA degradation 0 High O95782 AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3 0 160.09 47 31 49 20 977 107.5 7.03 29 6 3 39 6 4 9646770.495 152254098 9632876.813 5466236.756 4 27 11 12 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane protein binding;transporter activity "Pf01602, Pf02296, Pf02883, Pf13646" 160 ENSG00000196961.12 AP2A1 19 "Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle 11 High Q9HC36 "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" 0 155.026 55 23 48 23 420 47 8.73 23 2 46 2 29546624 351649655.6 5076005.422 11439629.44 1 26 7 7 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding "Pf00588, Pf08032" 55178 ENSG00000171861.10 RNMTL1; MRM3 17 rRNA modification in the mitochondrion 0 High Q9H2U1 ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2 0 177.982 33 26 48 24 1008 114.7 7.68 25 3 45 3 1277543.422 131442402.2 11381592.03 5768616.848 4 23 7 9 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02562, Pf04408, Pf07717" 170506 ENSG00000174953.13 DHX36 3 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; TRAF6 mediated IRF7 activation RNA degradation 0 High Q9Y3F4 Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1 0 126.643 66 20 48 20 350 38.4 5.12 3 20 4 1 3 40 4 1 3537022.828 244980741.4 3919336.141 3156212.953 9 20 4 7 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus protein binding;RNA binding Pf00400 11171 ENSG00000023734.10 STRAP 12 Downregulation of TGF-beta receptor signaling RNA transport 0 High Q04695 "Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2" 0 32.204 19 11 48 1 432 48.1 5.02 10 1 5 8 20 2 13 13 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol protein binding;receptor activity;signal transducer activity;structural molecule activity "Pf00038, Pf07888" 3872 ENSG00000128422.15 KRT17 17 Formation of the cornified envelope 0 High Q99729 Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2 0 62.974 31 12 48 11 332 36.2 8.21 3 12 6 4 7 26 10 5 2724636.025 276000400.9 15021421.38 9950944.6 5 11 8 9 cell organization and biogenesis;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08143, Pf13893, Pf14259" 3182 HNRNPAB 5 0 High P20671 Histone H2A type 1-D OS=Homo sapiens OX=9606 GN=HIST1H2AD PE=1 SV=2 0 35.898 46 7 48 4 130 14.1 10.9 3 7 5 5 6 24 9 9 17864534.48 1450358199 94985280.76 52200982.94 5 8 6 5 regulation of biological process chromosome;nucleus DNA binding;protein binding Pf00125 3013 ENSG00000196866.2 HIST1H2AD 6 SIRT1 negatively regulates rRNA expression; UCH proteinases; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Metalloprotease DUBs; DNA methylation; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Systemic lupus erythematosus; Alcoholism 4 High P0C0L4 Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2 0 51.117 8 15 47 15 1744 192.7 7.08 4 12 10 5 24 18 2857922.145 18035354.5 49142038.31 48732833.04 3 6 14 14 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane;organelle lumen catalytic activity;enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 720; 721 ENSG00000244731.7 C4A; C4B 6 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5 Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Staphylococcus aureus infection 0 High Q01081 Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3 0 113.029 62 12 46 12 240 27.9 8.81 12 4 3 37 6 3 1762361.625 394378082.7 12603825.01 5512680.282 3 14 7 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;transport nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf00076, Pf00642, Pf13893" 7307; 102724594 ENSG00000160201.11; ENSG00000275895.6 U2AF1; LOC102724594; U2AF1L5 21 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Shigellosis 0 High Q5M775 Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1 0.002 2.774 1 2 46 1 1068 118.5 6.7 2 1 1 2 19 5 10 12 5889460.5 23929154 7370752.5 3047336.25 1 1 1 1 cell organization and biogenesis;metabolic process;transport cytoskeleton;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding;transporter activity "Pf00307, Pf01496, Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf05478, Pf05667, Pf06160, Pf07888, Pf09730, Pf10174, Pf11971, Pf12128" 92521 ENSG00000128487.16 SPECC1 17 0 High P08670 Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4 0 58.225 44 20 46 20 466 53.6 5.12 11 2 13 7 16 3 17 10 12330070.46 521689127.4 36929934.5 15326920.2 11 8 14 12 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;RNA binding;structural molecule activity "Pf00038, Pf04111, Pf04156, Pf04732, Pf05622, Pf10186" 7431 ENSG00000026025.15 VIM 10 Interleukin-4 and 13 signaling; Caspase-mediated cleavage of cytoskeletal proteins; Striated Muscle Contraction MicroRNAs in cancer; Epstein-Barr virus infection 0 High Q9NVN8 Guanine nucleotide-binding protein-like 3-like protein OS=Homo sapiens OX=9606 GN=GNL3L PE=1 SV=1 0 115.405 46 24 45 24 582 65.5 8.44 24 2 43 2 15037355.91 209611996.6 3025928.469 1608317.613 4 23 5 6 regulation of biological process cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf01926, Pf02421, Pf11849" 54552 ENSG00000130119.15 GNL3L X Ribosome biogenesis in eukaryotes 0 High Q8WWM7 Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2 0 138.7 32 21 45 21 1075 113.3 8.59 1 21 1 44 7263291.32 202269743.5 6371386.797 5964463.59 5 21 4 6 Acetyl [N-Term] cell organization and biogenesis;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf06741, Pf07145, Pf09770, Pf14438" 11273 ENSG00000168488.18 ATXN2L 16 0 High P83881 60S ribosomal protein L36a OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2 0 46.495 46 9 45 2 106 12.4 10.58 2 9 2 3 4 32 4 5 3591221.781 1784231167 18843521.71 7479009.219 3 10 4 3 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00935 6173 ENSG00000241343.9 RPL36A X Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 8 High Q14498 RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2 0 119.934 36 18 45 18 530 59.3 10.1 18 3 3 37 5 3 2934215.313 294250151.8 16267864.5 6720751.509 3 18 10 8 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoskeleton;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259, Pf15519" 9584 ENSG00000131051.22 RBM39 20 0 High O75643 U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2 0 145.242 18 32 45 32 2136 244.4 6.06 29 4 5 35 4 6 1656903.931 87642634.58 8313101.357 5642093.191 6 30 13 15 cell differentiation;cell organization and biogenesis;metabolic process membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02889, Pf04851" 23020 ENSG00000144028.14 SNRNP200 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9UBU6 Protein FAM8A1 OS=Homo sapiens OX=9606 GN=FAM8A1 PE=1 SV=1 0 71.792 36 10 45 10 413 44.1 7.21 10 4 37 8 130134275.4 10968391.78 11 7 Met-loss+Acetyl [N-Term] membrane Pf06271 51439 ENSG00000137414.5 FAM8A1 6 0 High Q92900 Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2 0 137.785 32 30 45 30 1129 124.3 6.61 28 1 1 43 1 1 272325885.7 132695343.9 187983132.1 1542467.436 11 26 6 5 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf04851, Pf09416, Pf13086, Pf13087, Pf13245, Pf13604" 5976 ENSG00000005007.12 UPF1 19 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High P05386 60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1 0 141.167 96 7 45 5 114 11.5 4.32 1 7 2 1 1 39 3 2 7498171.656 813084333.2 31256050.19 16376999.1 1 5 4 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;ribosome enzyme regulator activity;protein binding;structural molecule activity Pf00428 6176 ENSG00000137818.11 RPLP1 15 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9UHB9 Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2 0 135.02 52 26 45 26 627 70.7 8.56 26 45 7613246 212175014.5 2900572.625 6456161.489 4 23 3 6 cell organization and biogenesis;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome protein binding;RNA binding 6730 ENSG00000167881.14 SRP68 17 SRP-dependent cotranslational protein targeting to membrane Protein export 0 High Q4G0J3 La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1 0 136.012 52 27 45 27 582 66.9 9.55 27 45 805228.9219 518310418.9 3449208.063 4992251.824 4 27 6 7 metabolic process cytosol;nucleus protein binding;RNA binding "Pf00076, Pf05383, Pf08777, Pf13893, Pf14259" 51574 ENSG00000174720.15 LARP7 4 0 High O00541 Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1 0 116.787 45 25 45 25 588 68 7.33 25 45 8255989.26 216006488.6 815670.7058 3 23 2 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process chromosome;cytosol;membrane;nucleus protein binding;RNA binding "Pf00533, Pf06732" 23481 ENSG00000100029.17 PES1 22 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q86TM6 E3 ubiquitin-protein ligase synoviolin OS=Homo sapiens OX=9606 GN=SYVN1 PE=1 SV=2 0 55.483 20 13 45 13 617 67.6 6.95 13 8 31 14 4722.739807 245181970.2 43562545.38 3 14 14 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf12906, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" 84447 ENSG00000162298.18 SYVN1 11 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes; Hedgehog ligand biogenesis Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 0 High Q9Y297 F-box/WD repeat-containing protein 1A OS=Homo sapiens OX=9606 GN=BTRC PE=1 SV=1 0 70.119 31 17 44 9 605 68.8 7.96 4 12 15 4 20 20 144532.2344 5171600.75 19518080.81 13360533.63 1 2 9 10 cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00400, Pf00646, Pf08801, Pf12125, Pf12937" 8945 ENSG00000166167.17 BTRC 10 Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Vpu mediated degradation of CD4; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Deactivation of the beta-catenin transactivating complex; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling Ubiquitin mediated proteolysis; Hippo signaling pathway; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Shigellosis 0 High P31946 14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3 0 64.226 51 12 44 5 246 28.1 4.83 1 5 9 11 1 7 15 21 2616.903809 4774179.375 11243073.5 14398703 1 3 4 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding Pf00244 7529 ENSG00000166913.12 YWHAB 20 "MAP2K and MAPK activation; mTORC1-mediated signalling; Negative regulation of MAPK pathway; ARMS-mediated activation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Frs2-mediated activation; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Interleukin-20 family signaling; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by BRAF and RAF fusions; Signaling by Hippo; Activation of BAD and translocation to mitochondria ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; TP53 Regulates Metabolic Genes; RAF activation; RHO GTPases activate PKNs" Viral carcinogenesis; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 0 High O95678 "Keratin, type II cytoskeletal 75 OS=Homo sapiens OX=9606 GN=KRT75 PE=1 SV=2" 0 43.486 15 11 44 1 551 59.5 7.74 8 5 6 7 17 6 7 14 9389116.75 1 cell death;cell differentiation cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf05957, Pf13166, Pf13514" 9119 ENSG00000170454.5 KRT75 12 Formation of the cornified envelope 0 High Q7KZI7 Serine/threonine-protein kinase MARK2 OS=Homo sapiens OX=9606 GN=MARK2 PE=1 SV=2 0 142.35 47 25 44 17 788 87.9 9.72 25 1 43 1 3670017.625 164974487.6 7311143.691 8223611.184 3 23 7 8 cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00069, Pf00627, Pf02149, Pf07714, Pf14531" 2011 ENSG00000072518.20 MARK2 11 8 High Q9Y6M1 Insulin-like growth factor 2 mRNA-binding protein 2 OS=Homo sapiens OX=9606 GN=IGF2BP2 PE=1 SV=2 0 105.729 38 18 44 16 599 66.1 8.46 17 3 1 39 4 1 1116162.766 401383254.5 2278934.281 2131723.773 2 17 4 4 regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus protein binding;RNA binding;translation regulator activity "Pf00013, Pf00076, Pf13014, Pf13083, Pf13893, Pf14259" 10644 ENSG00000073792.15 IGF2BP2 3 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 0 High Q8IZL8 "Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2" 0 156.66 29 21 43 21 1130 119.6 4.34 21 43 671235.2422 246948474.3 1738820.305 1367137.991 4 20 6 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus protein binding;RNA binding "Pf08166, Pf08167" 27043 ENSG00000141456.14 PELP1 17 Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression 0 High Q9BZI7 Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1 0 133.394 55 26 43 26 483 57.7 9.48 26 43 2830893.958 232945936.4 6082459.82 1191222.735 7 25 6 6 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding;transporter activity Pf03467 65109 ENSG00000125351.11 UPF3B X mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High Q9UM54 Unconventional myosin-VI OS=Homo sapiens OX=9606 GN=MYO6 PE=1 SV=4 0 81.577 22 21 43 21 1294 149.6 8.53 1 13 12 6 2 15 20 6 2287948.155 41281163.13 21727457.63 8297903.672 6 14 13 11 cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00529" 4646 MYO6 6 Gap junction degradation; Trafficking of AMPA receptors 0 High O95602 DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2 0 189.474 29 34 43 34 1720 194.7 7.03 33 1 42 1 4164018.695 91612080.59 2079418.336 2465684.924 3 27 4 5 metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" 25885 ENSG00000068654.15 POLR1A 2 RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation Purine metabolism; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q96PK6 RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2 0 107.461 33 16 43 16 669 69.4 9.67 3 14 6 3 3 28 7 5 2963485.438 132260804.2 18643813.69 14615811.59 5 16 9 8 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10432; 100526737 ENSG00000239306.4 RBM14; RBM14-RBM4 11 RUNX2 regulates bone development 0 High Q9H0S4 Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1 0 120.002 55 19 43 19 455 50.6 9.1 19 1 42 1 1061664.898 259574911.4 1955177.141 1544667.185 3 19 4 8 Met-loss+Acetyl [N-Term] cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 51202 ENSG00000213782.7 DDX47 12 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High P08621 U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2 0 91.839 49 16 42 16 437 51.5 9.94 2 15 3 1 5 27 7 3 7214647.469 203823458.6 9323374.781 3412267.02 4 15 4 6 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf12220, Pf13893, Pf14259" 6625 ENSG00000104852.14 SNRNP70 19 mRNA Splicing - Major Pathway Spliceosome 0 High P54132 Bloom syndrome protein OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1 0 169.815 31 30 42 30 1417 158.9 7.49 1 28 2 1 39 2 7719031.504 123239679.6 7505541.5 6717087.906 6 23 8 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382" 641 ENSG00000197299.10 BLM 15 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; SUMOylation of DNA damage response and repair proteins; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Fanconi anemia pathway 0 High P56270 Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1 0 136.447 39 15 42 11 477 48.6 8.95 15 42 159849.6094 199905837.6 2099974.063 4077648.688 1 14 3 3 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding;RNA binding Pf13465 4150 ENSG00000103495.13 MAZ 16 2 High Q6P2Q9 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2 0 135.002 17 32 42 32 2335 273.4 8.84 2 30 2 3 2 35 2 3 4000491.859 115804287.1 5754315.875 5586721.391 7 26 5 10 cell organization and biogenesis;metabolic process;response to stimulus membrane;nucleus;spliceosomal complex catalytic activity;protein binding;RNA binding "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" 10594 ENSG00000174231.16; ENSG00000274442.2 PRPF8 17; CHR_HSCHR17_1_CTG2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q12904 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2 0 165.022 68 16 42 16 312 34.3 8.43 16 2 2 38 2 2 1888552.859 232513934.1 7736906.875 6182361.039 2 16 5 6 cell communication;cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus protein binding;RNA binding Pf01588 9255 ENSG00000164022.16 AIMP1 4 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins 0 High P40937 Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1 0 139.217 69 20 41 20 340 38.5 7.2 19 3 2 36 3 2 20684562.49 274582938.3 9016254.102 9074792.404 4 20 9 12 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03215, Pf05496, Pf06068, Pf08542, Pf13086, Pf13173, Pf13177, Pf13401, Pf13479" 5985 ENSG00000111445.13 RFC5 12 Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA) DNA replication; Mismatch repair; Nucleotide excision repair 0 High Q9Y385 Ubiquitin-conjugating enzyme E2 J1 OS=Homo sapiens OX=9606 GN=UBE2J1 PE=1 SV=2 0 90.583 59 15 41 15 318 35.2 6.74 7 14 10 31 834313.2001 36622882.03 152646068.3 2 10 14 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding Pf00179 51465 ENSG00000198833.6 UBE2J1 6 Antigen processing: Ubiquitination & Proteasome degradation Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson's disease 0 High P05455 Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2 0 127.441 53 22 41 22 408 46.8 7.12 22 1 1 38 2 1 22924608.5 251209060.8 35145507.32 20364172.21 2 21 10 11 metabolic process;transport cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf05383, Pf08777, Pf14259" 6741 ENSG00000138385.15 SSB 2 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination Systemic lupus erythematosus 0 High P22492 Histone H1t OS=Homo sapiens OX=9606 GN=HIST1H1T PE=2 SV=4 0 55.868 27 8 41 3 207 22 11.71 2 8 1 2 3 35 1 2 11723531.5 3 cell differentiation;cell organization and biogenesis;development chromosome;nucleus DNA binding Pf00538 3010 ENSG00000187475.5 HIST1H1T 6 0 High P07996 Thrombospondin-1 OS=Homo sapiens OX=9606 GN=THBS1 PE=1 SV=2 0 75.402 24 19 41 19 1170 129.3 4.94 1 14 14 1 19 21 707795.75 106217592.3 50446062.88 38629709.77 2 5 15 16 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;extracellular;organelle lumen metal ion binding;protein binding "Pf00090, Pf00093, Pf02412, Pf05735, Pf12947" 7057 ENSG00000137801.10 THBS1 15 Platelet degranulation ; Integrin cell surface interactions; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Defective B3GALTL causes Peters-plus syndrome (PpS); O-glycosylation of TSR domain-containing proteins; Signaling by PDGF; Syndecan interactions TGF-beta signaling pathway; MicroRNAs in cancer; Rap1 signaling pathway; Phagosome; Focal adhesion; Malaria; Proteoglycans in cancer; p53 signaling pathway; Bladder cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q14103 Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1 0 104.023 42 17 41 15 355 38.4 7.81 16 4 3 32 6 3 7442330.012 442851886.1 37478964.37 17415307.56 8 18 7 10 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3184 ENSG00000138668.18 HNRNPD 4 mRNA Splicing - Major Pathway 2 High Q9Y2X3 Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1 0 170.153 46 19 41 19 529 59.5 8.92 18 4 1 35 5 1 27643605.55 208410703 5680596.859 3364897.574 5 18 7 7 cell growth;metabolic process cytosol;membrane;nucleus protein binding;RNA binding "Pf01798, Pf08060, Pf08156" 51602 ENSG00000055044.10 NOP58 2 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SUMOylation of RNA binding proteins Ribosome biogenesis in eukaryotes 0 High Q00325 "Phosphate carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2" 0 26.963 25 11 41 11 362 40.1 9.38 2 4 6 11 3 4 11 23 1616180.986 26908860.42 34118822.69 75581171.75 4 8 8 11 transport membrane;mitochondrion protein binding;transporter activity Pf00153 5250 ENSG00000075415.12 SLC25A3 12 0 High O76094 Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3 0 165.228 43 24 41 24 671 74.6 9.26 23 1 40 1 650546.4102 321599477.1 2065280.172 2177661.811 3 25 5 6 cell organization and biogenesis;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum protein binding;RNA binding "Pf08492, Pf12569, Pf12895, Pf13424, Pf14559" 6731 ENSG00000174780.15 SRP72 4 SRP-dependent cotranslational protein targeting to membrane Protein export 0 High P02768 Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2 0 34.231 15 10 41 10 609 69.3 6.28 3 4 5 9 4 4 11 22 3394171.124 108307164.9 73428653.47 71576616.09 4 5 6 10 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi;nucleus;organelle lumen antioxidant activity;catalytic activity;DNA binding;metal ion binding;protein binding Pf00273 213 ENSG00000163631.16 ALB 4 "Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging of heme from plasma; Platelet degranulation ; Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR); HDL remodeling; Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR); Transport of organic anions; Recycling of bile acids and salts" Thyroid hormone synthesis 0 High Q08170 Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2 0 65.877 28 15 40 9 494 56.6 11.52 2 14 4 1 3 31 5 1 2869453.45 465757588.9 20798974.69 10564727.13 4 14 7 9 metabolic process;regulation of biological process;response to stimulus;transport nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6429 ENSG00000116350.16 SRSF4 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 7 High P14923 Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3 0 70.353 30 17 40 15 745 81.7 6.14 9 1 9 9 17 1 10 12 13478275.78 8498527.438 14810018.25 11482860.66 9 7 10 10 cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen protein binding;signal transducer activity;structural molecule activity Pf00514 3728 ENSG00000173801.16 JUP 17 Adherens junctions interactions; Neutrophil degranulation; Formation of the cornified envelope; VEGFR2 mediated vascular permeability Arrhythmogenic right ventricular cardiomyopathy (ARVC); Acute myeloid leukemia; Pathways in cancer; Transcriptional misregulation in cancer 0 High P17987 T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1 0 62.446 40 17 40 17 556 60.3 6.11 2 13 7 10 3 14 8 15 3432531.352 30533698.11 19729493.73 20697519.7 6 12 11 12 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi nucleotide binding;protein binding;RNA binding Pf00118 6950 ENSG00000120438.11 TCP1 6 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC; Interleukin-12 family signaling 0 High P40938 Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2 0 112.49 60 21 40 21 356 40.5 8.34 20 3 2 34 4 2 2064482.781 216706360.4 3892761.891 3370493.091 6 20 6 5 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding "Pf03215, Pf08542, Pf13177, Pf13401" 5983 ENSG00000133119.12 RFC3 13 Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA) DNA replication; Mismatch repair; Nucleotide excision repair 0 High Q9Y5J1 U3 small nucleolar RNA-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=UTP18 PE=1 SV=3 0 168.45 55 20 40 20 556 62 8.76 20 2 38 2 1453104.416 163229452.5 5427580.027 1627864.54 2 17 4 5 metabolic process membrane;nucleus protein binding;RNA binding 51096 ENSG00000011260.13 UTP18 17 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9Y224 "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" 0 149.054 63 14 40 14 244 28.1 6.65 3 14 4 3 3 29 4 4 3798024.078 307050522.4 20869220.63 6869535.714 6 14 9 7 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus protein binding;RNA binding Pf10036 51637 ENSG00000087302.8 C14orf166; RTRAF 14 tRNA processing in the nucleus 0 High Q8NI36 WD repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=WDR36 PE=1 SV=1 0 175.489 38 27 40 27 951 105.3 7.53 27 2 38 2 964511.9375 182718815.1 5376864.234 4702595.467 1 28 5 9 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00400, Pf04192" 134430 ENSG00000134987.11 WDR36 5 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q14457 Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2 0 46.96 32 13 40 13 450 51.9 4.89 2 10 11 2 19 19 3345314.789 96827311.56 58850452.09 48460737.78 2 4 12 13 cell communication;cell death;cell division;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;nucleus;vacuole protein binding "Pf04111, Pf12777, Pf13851, Pf15285" 8678 ENSG00000126581.12 BECN1 17 Ub-specific processing proteases; Macroautophagy; Interleukin-7 signaling Apoptosis - multiple species; Autophagy 0 High Q9UEG4 Zinc finger protein 629 OS=Homo sapiens OX=9606 GN=ZNF629 PE=1 SV=2 0 124.658 35 21 40 19 869 96.6 7.93 21 40 3216243.25 168743902.3 4512955.188 1751065.688 2 21 6 4 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465, Pf14353" 23361 ENSG00000102870.5 ZNF629 16 2 High O14979 Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3 0 68.08 23 11 40 9 420 46.4 9.57 1 10 5 4 5 21 9 5 113963.0469 119410159.4 10826560.27 14692539.98 1 8 5 6 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 9987 ENSG00000152795.17 HNRNPDL; HNRPDL 4 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling 0 High Q14692 Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens OX=9606 GN=BMS1 PE=1 SV=1 0 137.161 30 29 39 29 1282 145.7 6.44 29 39 2431301.051 192809162.5 19161752.98 18445108 6 28 5 9 cell organization and biogenesis;metabolic process nucleus catalytic activity;nucleotide binding;RNA binding "Pf04950, Pf08142" 9790 ENSG00000165733.7 BMS1 10 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P07237 Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3 0 69.933 39 17 39 17 508 57.1 4.87 2 7 14 10 2 7 17 13 4201029.965 30848943.31 33833074.47 25233014.55 6 12 15 16 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding;RNA binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13899, Pf13905" 5034 ENSG00000185624.14 P4HB 17 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); VLDL assembly; Chylomicron assembly; Collagen biosynthesis and modifying enzymes; Interleukin-12 family signaling; Detoxification of Reactive Oxygen Species; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High Q8N5F7 NF-kappa-B-activating protein OS=Homo sapiens OX=9606 GN=NKAP PE=1 SV=1 0 55.006 26 8 39 8 415 47.1 10.11 5 6 4 7 9 7 8 15 11578698.19 54416264.44 26075263.75 23403770.13 6 6 7 8 cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus DNA binding;protein binding;RNA binding Pf06047 79576 ENSG00000101882.9 NKAP X 0 High O43663 Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2 0 142.451 48 25 39 24 620 71.6 6.68 23 2 1 36 2 1 58922337.86 192255417 5930260.578 5248195.836 4 22 7 9 cell division;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding Pf03999 9055 ENSG00000198901.13 PRC1 15 RHO GTPases activate CIT 1 High Q14191 Werner syndrome ATP-dependent helicase OS=Homo sapiens OX=9606 GN=WRN PE=1 SV=2 0 87.702 19 22 39 22 1432 162.4 6.34 1 15 17 1 20 18 3626314.5 29667241.22 36419925.5 67153693.36 3 11 18 20 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00270, Pf00271, Pf00570, Pf01612, Pf09382, Pf14493" 7486 ENSG00000165392.9 WRN 8 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; SUMOylation of DNA damage response and repair proteins; Resolution of D-loop Structures through Holliday Junction Intermediates 0 High Q9NQT5 Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3 0 132.678 82 16 39 16 275 29.6 8.1 16 1 37 2 933395.3633 283235137.8 3034670.25 1132328.43 4 16 5 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding 51010 ENSG00000107371.12 EXOSC3 9 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High P55209 Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1 0 99.778 35 12 39 11 391 45.3 4.46 1 12 3 1 1 33 4 1 1329816.453 373240202.3 4290888.164 3727610.058 2 11 5 6 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding Pf00956 4673 ENSG00000187109.13 NAP1L1 12 1 High P01889 "HLA class I histocompatibility antigen, B-7 alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3" 0 83.813 52 14 39 7 362 40.4 5.85 2 14 3 36 307017.1875 5222473.75 2528634.313 62465234.5 1 2 2 7 regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;Golgi;membrane protein binding "Pf00129, Pf06623, Pf07654" 3106 ENSG00000234745.10 HLA-B 6 "Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity; HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation 1 High P09661 U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2 0 96.495 61 16 38 16 255 28.4 8.62 16 1 1 36 1 1 3405209.086 289159344.5 7787190.195 4508580.015 4 18 4 8 Met-loss [N-Term] metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex protein binding;RNA binding "Pf12799, Pf13855, Pf14580" 6627 ENSG00000131876.16 SNRPA1 15 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway Spliceosome 0 High O43660 Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1 0 143.999 40 15 38 15 514 57.2 9.17 15 38 917932.7969 138093186 5708250.563 5896985.406 2 16 3 3 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus;spliceosomal complex catalytic activity;protein binding Pf00400 5356 ENSG00000171566.11 PLRG1 4 mRNA Splicing - Major Pathway Spliceosome 0 High Q969Q0 60S ribosomal protein L36a-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3 0 46.434 46 9 38 2 106 12.5 10.65 1 9 1 1 3 31 2 2 105428708 450056 2 1 metabolic process cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;structural molecule activity Pf00935 6166 ENSG00000165502.6 RPL36AL 14 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High A6NKD9 Coiled-coil domain-containing protein 85C OS=Homo sapiens OX=9606 GN=CCDC85C PE=1 SV=1 0 60.727 38 14 38 14 419 45.2 6.96 8 12 15 23 9421.186523 12897305.88 30339427.44 33705212.57 1 3 10 13 development Pf10226 317762 ENSG00000205476.8 CCDC85C 14 0 High Q07955 Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2 0 43.751 52 12 38 11 248 27.7 10.36 1 11 2 1 2 32 3 1 1813059.773 207982682.1 5515611.25 2620127.016 2 12 2 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6426 ENSG00000136450.12 SRSF1 17 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 1 High Q9UKN8 General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2 0 139.91 44 25 38 25 822 91.9 6.65 1 25 1 37 1654725.856 88762046.5 1889805.172 1172891.404 7 20 3 6 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding "Pf12657, Pf12660" 9329 ENSG00000125484.11 GTF3C4 9 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 High Q9UNF1 Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2 0 57.797 28 13 38 12 606 64.9 9.32 9 7 10 11 9 18 462181.3125 28327739.28 18160705.83 20547342.52 1 10 7 11 transport cytosol;extracellular;membrane;nucleus;organelle lumen protein binding Pf01454 10916 ENSG00000102316.16 MAGED2 X Platelet degranulation 1 High Q7Z417 Nuclear fragile X mental retardation-interacting protein 2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1 0 137.221 50 23 38 23 695 76.1 8.7 23 38 6163121.266 161141633.1 3302311.484 10099701.3 6 22 5 10 cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding Pf15293 57532 ENSG00000108256.8 NUFIP2 17 0 High P50454 Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2 0 73.219 38 14 38 14 418 46.4 8.69 1 13 8 2 24 12 7042970.881 2332248.354 107699153.4 17149242.06 5 5 14 11 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;organelle lumen enzyme regulator activity;protein binding;RNA binding Pf00079 871 ENSG00000149257.13 SERPINH1 11 Collagen biosynthesis and modifying enzymes 0 High P52292 Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1 0 81.758 38 13 37 13 529 57.8 5.4 2 12 7 3 2 21 11 3 3967956.594 1136819564 8365008.051 6869062.609 4 13 9 8 metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;transporter activity "Pf00514, Pf01749, Pf13513, Pf13646" 3838 ENSG00000182481.8 KPNA2 17 ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Sensing of DNA Double Strand Breaks Influenza A 0 High Q2TAY7 WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2 0 133.827 51 19 37 19 513 57.5 7.18 19 2 1 34 2 1 710785.5938 139814463.5 3081097.938 4264621.743 4 19 4 4 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex protein binding Pf00400 55234 ENSG00000122692.8 SMU1 9 0 High O43290 U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1 0 142.889 37 24 37 24 800 90.2 6.13 24 37 65088842.1 129856803.5 13348080.13 17107929.24 4 23 10 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;nucleus;spliceosomal complex protein binding;RNA binding Pf03343 9092 ENSG00000175467.14 SART1 11 mRNA Splicing - Major Pathway Spliceosome 0 High P63244 Receptor of activated protein C kinase 1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3 0 100.08 59 16 37 16 317 35.1 7.69 16 2 2 33 2 2 3400733.959 254298739.1 4309059.695 2813461.03 6 16 5 5 Met-loss+Acetyl [N-Term] cell death;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome enzyme regulator activity;protein binding;RNA binding;structural molecule activity Pf00400 10399 ENSG00000204628.11 GNB2L1; RACK1 5 Regulation of TNFR1 signaling; TNFR1-mediated ceramide production; TNFR1-induced NFkappaB signaling pathway Measles 0 High P63010 AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1 0 132.985 38 25 37 14 937 104.5 5.38 24 2 2 33 2 2 586189.5391 141602854.5 21340368.31 13272511.98 2 22 6 10 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane protein binding;transporter activity "Pf01602, Pf02883, Pf09066, Pf12717, Pf13646" 163 ENSG00000006125.17 AP2B1 17 "Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle 11 High O43790 "Keratin, type II cuticular Hb6 OS=Homo sapiens OX=9606 GN=KRT86 PE=1 SV=1" 0 100.135 45 18 37 11 486 53.5 5.66 17 2 35 2 7084907.281 203740128 6982732.164 3230727.527 4 18 6 4 cell death;regulation of biological process;transport cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf05557, Pf07888, Pf07926, Pf09726, Pf11559, Pf12128, Pf13166" 3892 ENSG00000170442.11 KRT86 12 Formation of the cornified envelope 8 High Q9UNQ2 Probable dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1 0 110.545 66 17 37 17 313 35.2 9.99 17 1 36 1 8175700.469 205714545.3 3222292.165 3512818.035 4 17 3 3 metabolic process;regulation of biological process cytosol;nucleus;organelle lumen catalytic activity;RNA binding "Pf00398, Pf13659" 27292 ENSG00000086189.9 DIMT1 5 rRNA modification in the nucleus and cytosol 0 High P82650 "28S ribosomal protein S22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" 0 107.248 43 15 37 15 360 41.3 7.9 1 15 4 2 1 29 5 2 2514438.484 175845761.3 3605527.375 5079315.289 3 14 4 6 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf10245 56945 ENSG00000175110.11 MRPS22 3 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q9H7E9 UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8ORF33 PE=1 SV=1 0 90.488 58 11 37 11 229 25 9.95 11 3 1 33 3 1 1394862.984 367122149.1 8799603.625 3516058.492 4 11 7 7 Met-loss+Acetyl [N-Term] protein binding Pf15393 65265 ENSG00000182307.12 C8orf33 8 0 High Q99848 Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2 0 71.909 46 14 37 14 306 34.8 10.1 1 14 4 1 1 31 4 1 235764.8594 309213932.4 7074928.523 2503349.469 1 14 6 6 metabolic process nucleus protein binding;RNA binding Pf05890 10969 ENSG00000117395.12 EBNA1BP2 1 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q9NNW5 WD repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1 0 146.682 30 22 36 22 1121 121.6 6.87 21 1 2 33 1 2 3498955.688 107596788.4 1981433.633 7870841.378 3 20 5 6 Acetyl [N-Term] regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding Pf00400 11180 ENSG00000178252.17 WDR6 3 0 High Q9H6R4 Nucleolar protein 6 OS=Homo sapiens OX=9606 GN=NOL6 PE=1 SV=2 0 144.732 32 23 36 23 1146 127.5 7.64 23 1 35 1 9987513.609 201590549.4 4510983.141 6559448.646 8 22 6 9 metabolic process;transport chromosome;mitochondrion;nucleus protein binding;RNA binding Pf03813 65083 ENSG00000165271.16 NOL6 9 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q15717 ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2 0 79.587 40 11 36 11 326 36.1 9.17 2 11 5 3 2 25 6 3 11355400.36 178795621.1 7623287.313 7896739.703 4 12 6 7 development;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 1994 ENSG00000066044.14 ELAVL1 19 HuR (ELAVL1) binds and stabilizes mRNA; mRNA Splicing - Major Pathway AMPK signaling pathway 0 High P78362 SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3 0 102.796 33 19 36 15 688 77.5 4.97 19 36 3260184.705 106262206.3 3150780.875 420668.875 5 14 4 3 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00069, Pf07714" 6733 ENSG00000135250.16 SRPK2 7 0 High Q2M2I8 AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3 0 101.743 31 18 36 18 961 103.8 6.6 12 14 16 20 77555080 33550720.94 23821492.8 1 18 16 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 22848 ENSG00000115977.18 AAK1 2 Cargo recognition for clathrin-mediated endocytosis 0 High Q9Y5A9 YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2 0 135.98 36 16 36 13 579 62.3 8.79 16 2 34 2 6660911.735 144174682.2 3908575.453 1498364.891 2 17 5 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding;RNA binding Pf04146 51441 ENSG00000198492.15 YTHDF2 1 3 High Q9BRJ6 Uncharacterized protein C7orf50 OS=Homo sapiens OX=9606 GN=C7ORF50 PE=1 SV=1 0 113.596 49 13 36 13 194 22.1 9.64 13 2 34 2 758335.75 418838502.6 9930278.313 5695432.266 2 13 6 6 protein binding;RNA binding Pf10180 84310 ENSG00000146540.14 C7orf50 7 0 High Q9P2K5 Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3 0 115.853 35 20 36 20 600 64.1 8.75 20 36 2124037.859 236473094.5 1403729.449 1576840.885 6 19 3 5 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08777, Pf11608, Pf13893, Pf14259" 50804 MYEF2 15 0 High Q15366 Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1 0 60.158 43 9 36 6 365 38.6 6.79 3 9 5 2 5 19 7 5 1810955.719 109497021.8 11127311.35 8939783.859 2 8 4 2 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 5094 ENSG00000197111.15 PCBP2 12 Negative regulators of DDX58/IFIH1 signaling; mRNA Splicing - Major Pathway 1 High O00159 Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4 0 74.173 23 21 36 21 1063 121.6 9.41 1 13 13 4 1 15 15 5 753825.0547 50031792.31 22672735.66 9634908.896 3 13 16 14 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 4641 ENSG00000197879.14 MYO1C 17 Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation 0 High P01857 Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1 0 4.636 5 2 36 2 330 36.1 8.19 2 2 2 2 7 4 9 16 234133799.2 204163601.7 660742964.6 733021170.9 3 3 3 3 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane catalytic activity;metal ion binding;protein binding "Pf07654, Pf08205" 3500 ENSG00000277633.5; ENSG00000211896.7 IGHG1 14; CHR_HSCHR14_3_CTG1 Regulation of Complement cascade; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-4 and 13 signaling; Role of phospholipids in phagocytosis 0 High Q13155 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2 0 95.684 61 14 36 14 320 35.3 8.22 2 14 2 3 2 28 3 3 7558563.25 252330352.5 4103587.336 4168295.953 6 14 3 5 Met-loss [N-Term] cell death;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf13410, Pf14497" 7965 ENSG00000106305.9 AIMP2 7 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins 0 High Q9NUL3 Double-stranded RNA-binding protein Staufen homolog 2 OS=Homo sapiens OX=9606 GN=STAU2 PE=1 SV=2 0 92.482 45 21 35 19 570 62.6 9.61 21 1 34 1 559314.9844 124788727.6 8133337.5 12270922.23 3 18 1 3 0 High P61981 14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2 0 35.344 39 12 35 6 247 28.3 4.89 1 3 7 11 1 4 11 19 2357.854004 8985124.692 16211204.75 19663884.69 1 5 4 7 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion enzyme regulator activity;protein binding;RNA binding Pf00244 7532 ENSG00000170027.6 YWHAG 7 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs Viral carcinogenesis; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 2 High Q8N8A6 ATP-dependent RNA helicase DDX51 OS=Homo sapiens OX=9606 GN=DDX51 PE=1 SV=3 0 142.658 43 20 35 20 666 72.4 8.16 20 35 10954707.31 92012320 896495.3008 4827396.75 3 18 3 4 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02063, Pf04851" 317781 ENSG00000185163.9 DDX51 12 0 High P42696 RNA-binding protein 34 OS=Homo sapiens OX=9606 GN=RBM34 PE=1 SV=2 0 100.002 46 20 35 20 430 48.5 10.11 20 35 307014.272 168984460.1 3545135.547 9531513.734 2 19 5 7 nucleus RNA binding "Pf00076, Pf14259" 23029 ENSG00000188739.14 RBM34 1 0 High Q12788 Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2 0 134.591 40 24 35 24 808 89 6.9 24 2 33 2 2098499.742 179875094.6 3412167.059 54452.58008 3 24 7 3 metabolic process nucleus protein binding;RNA binding "Pf00400, Pf08625" 10607 ENSG00000183751.14 TBL3 16 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P35250 Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3 0 95.946 51 14 35 14 354 39.1 6.44 1 13 2 1 31 3 789873.2188 248076879 3532896.438 1485593.813 3 12 3 3 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf01078, Pf01443, Pf03215, Pf05496, Pf08542, Pf13086, Pf13173, Pf13177, Pf13191, Pf13207, Pf13238, Pf13245, Pf13401" 5982 ENSG00000049541.10 RFC2 7 Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA) DNA replication; Mismatch repair; Nucleotide excision repair 0 High Q96RN5 Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2 0 44.657 15 10 35 10 788 86.7 9.42 4 2 7 7 5 3 13 14 3761048.219 43708042.31 50928615.42 28865576.84 3 5 8 8 metabolic process;regulation of biological process cytoplasm;membrane;nucleus protein binding Pf09606 51586 ENSG00000099917.17 MED15 22 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 High P19525 "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" 0 103.417 40 17 35 17 551 62.1 8.4 17 1 34 1 1155727.836 198791288.3 407706.0938 1346754.959 3 16 1 6 Met-loss+Acetyl [N-Term] cell communication;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus;ribosome catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00035, Pf00069, Pf07714" 5610 ENSG00000055332.16 EIF2AK2 2 Inhibition of PKR; ISG15 antiviral mechanism Viral carcinogenesis; Epstein-Barr virus infection; Protein processing in endoplasmic reticulum; Measles; Herpes simplex infection; Hepatitis C; Influenza A 0 High Q6PCB5 Round spermatid basic protein 1-like protein OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2 0 134.308 35 20 35 19 846 94.8 8.78 20 35 20221373.27 101416867.1 3664785.641 139285.875 3 20 4 1 Met-loss+Acetyl [N-Term] nucleus 222194 ENSG00000187257.15 RSBN1L 7 0 High Q07000 "HLA class I histocompatibility antigen, Cw-15 alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1" 0 62.437 32 10 35 1 366 40.8 6.33 1 3 2 10 1 5 3 26 regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;Golgi;membrane protein binding "Pf00129, Pf07654" 3107 HLA-C 6 "Interferon alpha/beta signaling; ER-Phagosome pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" 0 High P63241 Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2 0 107.909 73 11 34 11 154 16.8 5.24 11 4 1 26 7 1 11141289.19 182327878.8 12024129.81 5528293.766 2 13 8 5 Met-loss+Acetyl [N-Term] cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus protein binding;RNA binding Pf01287 1984 ENSG00000132507.17 EIF5A 17 Hypusine synthesis from eIF5A-lysine 0 High O75934 Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1 0 110.24 80 13 34 13 225 26.1 5.66 13 1 33 1 664747.3984 249435313.1 1290022.938 8092700.124 2 13 2 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process nucleus;spliceosomal complex protein binding Pf05700 10286 ENSG00000116752.5 BCAS2 1 mRNA Splicing - Major Pathway Spliceosome 0 High P36542 "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" 0 39.362 48 12 34 12 298 33 9.22 2 6 5 10 2 7 8 17 16298514.7 44971562.25 16003014.76 33384188.97 3 7 8 11 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;organelle lumen catalytic activity;RNA binding;transporter activity Pf00231 509 ENSG00000165629.19 ATP5C1 10 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High P62861 40S ribosomal protein S30 OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1 0 21.973 56 7 34 7 59 6.6 12.15 1 7 3 1 1 23 8 2 1354110.375 1626696463 23540349.72 8798311.535 1 8 2 2 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;ribosome RNA binding;structural molecule activity Pf04758 2197 FAU 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" 0 High O60832 H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3 0 124.495 45 19 34 19 514 57.6 9.42 19 34 927709.5469 233411666.3 12130583.78 26512504.46 3 18 4 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;protein binding;RNA binding "Pf01472, Pf01509, Pf08068" 1736 ENSG00000130826.17 DKC1 X rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase Ribosome biogenesis in eukaryotes 0 High P49458 Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2 0 31.468 65 8 34 8 86 10.1 7.97 1 8 3 3 1 23 5 5 1317564.688 951019191.1 30739711.75 28406056.16 4 9 4 4 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol protein binding;RNA binding Pf05486 6726; 653226 ENSG00000143742.12 SRP9; SRP9P1 1; 10 SRP-dependent cotranslational protein targeting to membrane Protein export 0 High Q14978 Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2 0 55.52 24 14 34 14 699 73.6 9.47 3 12 3 4 4 22 3 5 7915920.25 59055820.32 28024057.94 34754485.2 5 13 10 11 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus nucleotide binding;protein binding;RNA binding Pf05022 9221 ENSG00000166197.16 NOLC1 10 0 High Q15365 Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2 0 58.217 50 10 34 8 356 37.5 7.09 2 10 3 2 4 20 6 4 4525264.902 118567741 13595159.19 14480891.02 5 10 4 6 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 5093 ENSG00000169564.6 PCBP1 2 mRNA Splicing - Major Pathway Spliceosome 2 High Q8WXX5 DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1 0 121.851 71 19 34 19 260 29.9 5.73 19 34 1326500.945 343761826 2836958.35 1794732.534 3 19 6 9 Met-loss [N-Term] regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus protein binding Pf00226 23234 ENSG00000213551.4 DNAJC9 10 0 High O43172 U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2 0 125.497 51 20 34 20 522 58.4 7.42 20 34 1452795 152556413 1052911.656 348888.8594 1 17 2 2 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00400, Pf08799" 9128 ENSG00000136875.12 PRPF4 9 mRNA Splicing - Major Pathway Spliceosome 0 High Q92901 60S ribosomal protein L3-like OS=Homo sapiens OX=9606 GN=RPL3L PE=2 SV=3 0 26.415 6 4 34 1 407 46.3 10.45 1 4 3 1 3 22 7 2 59594124 1 cell organization and biogenesis;metabolic process membrane;ribosome RNA binding;structural molecule activity Pf00297 6123 ENSG00000140986.7 RPL3L 16 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P07900 Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5 0 73.421 24 18 33 5 732 84.6 5.02 6 11 10 6 14 13 2666733.875 8106394.313 3285527.609 2 5 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 3320 ENSG00000080824.18 HSP90AA1 14 "Sema3A PAK dependent Axon repulsion; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Scavenging by Class F Receptors; Neutrophil degranulation; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); vRNP Assembly; Downregulation of ERBB2 signaling; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Constitutive Signaling by EGFRvIII; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Recruitment of mitotic centrosome proteins and complexes; HSF1 activation; Attenuation phase; eNOS activation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; VEGFR2 mediated vascular permeability; PIWI-interacting RNA (piRNA) biogenesis; Interleukin-4 and 13 signaling" NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; PI3K-Akt signaling pathway; Antigen processing and presentation 0 High Q9NXF1 Testis-expressed protein 10 OS=Homo sapiens OX=9606 GN=TEX10 PE=1 SV=2 0 151.174 36 25 33 25 929 105.6 9.36 25 33 1235783.656 118064189.6 64031.71875 1533674.28 3 25 1 6 metabolic process cytoplasm;nucleus protein binding Pf12333 54881 ENSG00000136891.13 TEX10 9 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q92552 "28S ribosomal protein S27, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" 0 111.614 48 16 33 16 414 47.6 6.18 16 1 2 30 1 2 527593.7656 141489243.7 49852614.3 32618258.76 3 17 6 6 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion;ribosome protein binding;RNA binding "Pf10037, Pf12854, Pf13041" 23107 ENSG00000113048.16 MRPS27 5 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q71UM5 40S ribosomal protein S27-like OS=Homo sapiens OX=9606 GN=RPS27L PE=1 SV=3 0 32.206 39 4 33 1 84 9.5 9.45 2 4 2 4 3 17 6 7 191177.5781 28384714 2188101.125 2256639.672 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;ribosome enzyme regulator activity;metal ion binding;protein binding;RNA binding;structural molecule activity;translation regulator activity Pf01667 51065 ENSG00000185088.13 RPS27L 15 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q5C9Z4 Nucleolar MIF4G domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOM1 PE=1 SV=1 0 110.257 31 21 33 21 860 96.2 8.1 21 1 32 1 2449531.688 401660890.4 2828577.794 1900611.734 3 20 7 7 cell differentiation nucleus protein binding;RNA binding "Pf02847, Pf02854" 64434 ENSG00000146909.7 NOM1 7 0 High P07305 Histone H1.0 OS=Homo sapiens OX=9606 GN=H1F0 PE=1 SV=3 0 58.838 40 10 33 10 194 20.9 10.84 10 33 1110640777 773582972.8 12914454.22 6660510.516 3 15 5 5 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;metabolic process chromosome;cytoskeleton;Golgi;nucleus DNA binding;protein binding;RNA binding Pf00538 3005 ENSG00000189060.5 H1F0 22 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 0 High P98175 RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3 0 134.749 29 21 33 21 930 103.5 5.97 21 33 7293208.313 236511071.8 6367821.313 6760389.875 4 19 3 5 metabolic process;regulation of biological process nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf01585, Pf12656, Pf14259" 8241 ENSG00000182872.15 RBM10 X 0 High Q9H9L3 Interferon-stimulated 20 kDa exonuclease-like 2 OS=Homo sapiens OX=9606 GN=ISG20L2 PE=1 SV=1 0 104.961 56 20 33 20 353 39.1 9.94 20 33 80458.52344 118253978.3 3019671.406 3106677.352 1 20 3 7 Met-loss+Acetyl [N-Term] metabolic process nucleus catalytic activity;protein binding;RNA binding Pf00929 81875 ENSG00000143319.16 ISG20L2 1 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q07065 Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2 0 121.428 39 17 33 17 602 66 5.92 1 17 3 1 29 3 383170 93733152 6938146.313 4990798.047 2 16 6 7 metabolic process;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;organelle lumen RNA binding Pf13166 10970 ENSG00000136026.13 CKAP4 12 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Surfactant metabolism; Neutrophil degranulation Protein processing in endoplasmic reticulum 0 High Q9Y4W2 Ribosomal biogenesis protein LAS1L OS=Homo sapiens OX=9606 GN=LAS1L PE=1 SV=2 0 129.57 51 22 32 22 734 83 4.73 22 32 869823.9492 118950068.9 2330845.734 8148166.169 4 21 5 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;membrane;nucleus RNA binding Pf04031 81887 ENSG00000001497.16 LAS1L X Major pathway of rRNA processing in the nucleolus and cytosol 0 High O75390 "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" 0 33.745 24 12 32 12 466 51.7 8.32 1 8 12 1 13 18 19107067.75 36777119.19 38919509.69 2 9 12 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;RNA binding Pf00285 1431 ENSG00000062485.18 CS 12 Mitochondrial protein import; Metabolism of proteins; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism 0 High Q9Y3B2 Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1 0 61.636 75 9 32 9 195 21.4 8.24 9 1 2 29 1 2 213819957.9 1659236.934 498825.6172 9 3 2 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf10447, Pf14382" 51013 ENSG00000171311.12 EXOSC1 10 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High O95714 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2 0 52.769 5 20 32 20 4834 526.9 6.28 5 4 7 12 6 4 8 14 1886315.229 23508033.3 13978057.78 18516150.28 6 10 12 14 metabolic process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00173, Pf00415, Pf00569, Pf00632, Pf03256, Pf06701, Pf11515, Pf13540" 8924 ENSG00000128731.15 HERC2 15 G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Antigen processing: Ubiquitination & Proteasome degradation; SUMOylation of DNA damage response and repair proteins Ubiquitin mediated proteolysis 0 High Q8IUE6 Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=HIST2H2AB PE=1 SV=3 0 34.361 48 7 32 5 130 14 10.89 1 7 3 4 2 19 5 6 151629945.1 11627671.79 3195426.516 5 2 4 regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 317772 ENSG00000184270.4 HIST2H2AB 1 HDACs deacetylate histones; HATs acetylate histones; UCH proteinases; Ub-specific processing proteases; RMTs methylate histone arginines; Metalloprotease DUBs Systemic lupus erythematosus; Alcoholism 0 High P42166 "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" 0 56.215 24 12 32 4 694 75.4 7.66 1 3 6 10 1 3 10 18 1574402 3298114.906 3926079.266 4080984.063 1 2 3 4 Met-loss [N-Term] regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf03020, Pf08198, Pf11560" 7112 ENSG00000120802.13 TMPO 12 0 High Q04917 14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4 0 35.519 46 11 32 7 246 28.2 4.84 1 2 8 9 1 3 13 15 261730.9844 3981382.658 22663127.88 23885709.38 1 2 6 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion catalytic activity;protein binding Pf00244 7533 ENSG00000128245.14 YWHAH 22 Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs Viral carcinogenesis; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 0 High Q13895 Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3 0 128.946 65 20 32 20 437 49.6 8.12 20 1 31 1 2809768.414 124608293.1 862373.9922 1865299.551 7 19 4 8 cell differentiation;cell proliferation;metabolic process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf05291 705 ENSG00000112578.9 BYSL 6 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q9NVV4 "Poly(A) RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=MTPAP PE=1 SV=1" 0 120.6 40 17 32 17 582 66.1 9.04 17 32 9315639.703 124076109.3 4752444.535 7792193.191 3 17 5 7 metabolic process cytoplasm;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf03828 55149 ENSG00000107951.14 MTPAP 10 0 High Q9H6F5 Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1 0 86.019 43 12 32 12 360 40.2 10.33 12 32 304374388.8 3883329.078 3586216.016 12 3 5 nucleus protein binding;RNA binding 79080 ENSG00000110104.11 CCDC86 11 0 High Q8IW35 Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1 0 66.652 27 19 32 19 865 96.9 5.02 14 8 23 9 25517.62842 312262664.3 47931302.25 15451016.03 2 7 15 15 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding "Pf12799, Pf13855, Pf14580" 79598 ENSG00000182504.10 CEP97 3 Anchoring of the basal body to the plasma membrane 0 High Q9NZC9 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1 0 70.877 24 18 32 18 954 105.9 9.06 1 11 13 1 17 14 31128.58789 9751718.094 31272213.94 19249673.33 1 6 15 16 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf07443" 50485 ENSG00000138375.12 SMARCAL1 2 0 High Q7Z478 ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2 0 117.46 24 25 32 24 1369 155.1 8.09 25 32 2138486.5 77818917.38 41809018.8 4714079.379 1 20 5 6 metabolic process cytoplasm;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717" 54505 ENSG00000067248.9 DHX29 5 0 High P49590 "Probable histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" 0 89.56 47 18 31 18 506 56.9 8.24 18 31 273906.625 147473431.5 2925974.031 981348.1943 1 18 3 4 cell organization and biogenesis;metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00587, Pf03129, Pf12745, Pf13393" 23438 ENSG00000112855.14 HARS2 5 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q8IX01 SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2 0 108.594 24 19 31 19 1082 120.1 7.28 19 1 30 1 32694603.78 73335547.19 1277283.141 1601707.963 10 19 3 4 metabolic process nucleus RNA binding "Pf01585, Pf01805, Pf12656" 10147 ENSG00000064607.16 SUGP2 19 0 High P09012 U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3 0 51.995 34 7 31 5 282 31.3 9.83 1 7 4 3 2 20 5 4 1762934.313 81025341.38 17523585.75 12984384.38 2 7 4 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6626 ENSG00000077312.8 SNRPA 19 mRNA Splicing - Major Pathway Spliceosome 0 High P60660 Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2 0 40.864 67 8 31 8 151 16.9 4.65 2 4 8 5 2 8 16 5 2448581.711 56149669.96 43030582.8 51377414.63 4 6 8 8 Met-loss+Acetyl [N-Term] cellular component movement cytosol;membrane catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity "Pf00036, Pf13405, Pf13499" 4637 ENSG00000092841.18 MYL6 12 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs Vascular smooth muscle contraction; Oxytocin signaling pathway 0 High Q8NE71 ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2 0 115.326 32 23 31 23 845 95.9 6.8 23 31 1060525.859 142634331.8 3036441.125 1306870.078 3 22 3 5 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding;translation regulator activity "Pf00005, Pf13304" 23 ENSG00000225989.9; ENSG00000232169.9; ENSG00000204574.12; ENSG00000206490.11; ENSG00000236149.9; ENSG00000236342.8; ENSG00000231129.8 ABCF1 6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_MANN_CTG1 ABC-family proteins mediated transport 0 High P63220 40S ribosomal protein S21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1 0 82.995 64 6 31 6 83 9.1 8.5 6 1 1 29 1 1 2132208.347 485726337.6 5724637.584 3986619.756 5 8 4 3 Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome protein binding;RNA binding;structural molecule activity Pf01249 6227 ENSG00000171858.17 RPS21 20 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P61927 60S ribosomal protein L37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2 0 15.008 56 8 31 8 97 11.1 11.74 8 1 1 27 2 2 1167353423 16478947.86 11567860.74 8 4 5 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome metal ion binding;RNA binding;structural molecule activity Pf01907 6167 ENSG00000145592.13 RPL37 5 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q13206 Probable ATP-dependent RNA helicase DDX10 OS=Homo sapiens OX=9606 GN=DDX10 PE=1 SV=2 0 121.881 35 21 31 21 875 100.8 8.63 21 1 30 1 4674977.531 79362136.75 709425.4688 1504510.576 2 18 3 4 metabolic process cytoplasm catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf13959" 1662 ENSG00000178105.9 DDX10 11 0 High Q14151 Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1 0 69.162 10 8 31 1 953 107.4 6.16 4 4 6 7 6 4 11 10 5581143 527183.75 1 1 cell differentiation;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 9667 ENSG00000130254.11 SAFB2 19 0 High Q96B26 Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1 0 95.763 51 12 31 12 276 30 5.3 12 31 2554714.781 247274381.3 1395961.117 7009127.148 3 12 3 4 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf01138, Pf03725" 11340 ENSG00000120699.12 EXOSC8 13 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High Q8TEM1 Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3 0 70.579 13 20 31 20 1887 205 6.81 5 20 6 25 123619.5313 7718689.5 8802461.188 36327580.28 1 5 9 20 cell organization and biogenesis;metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane;nucleus protein binding Pf02368 23225 ENSG00000132182.11 NUP210 3 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High O94973 AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2 0 75.114 26 19 30 8 939 103.9 6.96 17 4 3 22 4 4 10820955.75 12861329.75 5489771.727 3049361.172 4 6 4 5 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane protein binding;transporter activity "Pf01602, Pf02296, Pf02883, Pf13646" 161 ENSG00000183020.13 AP2A2 11 "Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Neutrophil degranulation; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle 0 High Q96EY7 "Pentatricopeptide repeat domain-containing protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" 0 114.388 42 20 30 20 689 78.5 6.42 20 30 35842170.25 114504576.9 985670.3423 451188.8438 6 21 4 5 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding "Pf13041, Pf13812" 55037 ENSG00000132300.18 PTCD3 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q00059 "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" 0 62.49 38 13 30 13 246 29.1 9.72 13 30 2220724.063 211388168 871413.7813 734687.9375 2 13 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;mitochondrion;nucleus;organelle lumen DNA binding;protein binding;RNA binding "Pf00505, Pf09011" 7019 ENSG00000108064.10 TFAM 10 Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis Huntington's disease 0 High Q96CW1 AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2 0 68.383 42 18 30 18 435 49.6 9.54 16 2 27 3 20221313.38 254488060 16162435.47 9825128.354 2 16 6 7 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane protein binding;transporter activity Pf00928 1173 ENSG00000161203.13 AP2M1 3 "Cargo recognition for clathrin-mediated endocytosis; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle 0 High P27448 MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5 0 105.2 36 20 30 10 753 84.4 9.57 20 1 29 1 1883631.039 57218343.5 2576448.094 1264429.891 3 9 3 4 2 High Q13868 Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2 0 93.167 54 12 30 12 293 32.8 7.5 12 30 3878361.469 266291884.5 1548718.563 1940549.141 3 10 3 3 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding Pf14382 23404 ENSG00000130713.15 EXOSC2 9 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3 0 130.985 84 14 30 14 261 26.9 7.78 14 2 1 27 2 1 4094931.68 109137491.1 2204263.785 1148233.239 6 14 6 6 cell organization and biogenesis;metabolic process cytoplasm;membrane;mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding "Pf00106, Pf08659, Pf13561" 3028 ENSG00000072506.12 HSD17B10 X tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; Branched-chain amino acid catabolism; tRNA modification in the mitochondrion "Alzheimer's disease; Metabolic pathways; Valine, leucine and isoleucine degradation" 0 High P82930 "28S ribosomal protein S34, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" 0 50.009 50 11 30 11 218 25.6 9.98 1 11 3 4 1 22 3 4 586495.25 407945337.8 24043123.75 9305801.132 2 12 5 6 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity 65993 ENSG00000074071.14 MRPS34 16 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q12849 G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3 0 144.926 59 18 30 18 480 53.1 6.19 18 30 1958365.25 157468516 1047004.125 4623011.346 4 19 2 8 metabolic process cytoplasm;mitochondrion RNA binding "Pf00076, Pf14259" 2926 ENSG00000132463.13 GRSF1 4 Viral mRNA Translation 0 High Q8NFW8 N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2 0 105.695 44 16 30 16 434 48.3 7.93 16 30 952676.2188 152110541 2547529.688 1413555.734 2 17 3 3 metabolic process membrane;nucleus catalytic activity "Pf02348, Pf12804" 55907 ENSG00000111726.12 CMAS 12 Sialic acid metabolism Amino sugar and nucleotide sugar metabolism; Metabolic pathways 0 High Q00610 Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5 0 64.752 13 18 30 18 1675 191.5 5.69 5 3 14 7 5 3 15 7 4161347.508 27831767.06 15337790.19 9396763.8 6 5 13 15 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole protein binding;RNA binding;structural molecule activity "Pf00637, Pf01394, Pf04053, Pf09268, Pf13838" 1213 ENSG00000141367.11 CLTC 17 "Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Lysosome; Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle 0 High P37108 Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2 0 52.735 51 10 30 10 136 14.6 10.04 1 10 1 1 28 1 1599100.664 719005358.3 2739749.281 1667427.125 3 10 2 3 Met-loss [N-Term] cell organization and biogenesis;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen protein binding;RNA binding Pf02290 6727 ENSG00000140319.10 SRP14 15 Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane Protein export 0 High P35249 Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2 0 88.362 66 18 30 18 363 39.7 8.02 18 2 27 3 3278185.528 296676735.8 9368581.354 6670091.139 6 17 9 10 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03215, Pf05496, Pf08542, Pf09848, Pf13086, Pf13177, Pf13191, Pf13245, Pf13401, Pf13481, Pf13604" 5984 ENSG00000163918.10 RFC4 3 Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA) DNA replication; Mismatch repair; Nucleotide excision repair 0 High Q6PK04 Coiled-coil domain-containing protein 137 OS=Homo sapiens OX=9606 GN=CCDC137 PE=1 SV=1 0 66.059 44 12 30 12 289 33.2 10.93 1 12 1 4 24 2 74200208.31 173808816.3 10612626.14 50717913.32 3 12 2 3 chromosome protein binding;RNA binding 339230 ENSG00000185298.12 CCDC137 17 0 High P27824 Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2 0 70.578 30 14 30 14 592 67.5 4.6 1 4 14 1 5 24 391024.7969 13261091.87 15752866.13 48625594.44 2 5 8 14 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;organelle lumen;ribosome metal ion binding;protein binding;RNA binding Pf00262 821 ENSG00000127022.14; ENSG00000283777.1 CANX 5; CHR_HG30_PATCH "Assembly of Viral Components at the Budding Site; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Calnexin/calreticulin cycle; MHC class II antigen presentation" Protein processing in endoplasmic reticulum; HTLV-I infection; Phagosome; Thyroid hormone synthesis; Antigen processing and presentation 0 High Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 OS=Homo sapiens OX=9606 GN=FTSJ3 PE=1 SV=2 0 72.33 26 19 30 19 847 96.5 8.4 18 2 27 3 4630156.141 131310747.1 9934129.516 10587944.79 4 19 7 7 metabolic process nucleus catalytic activity;protein binding;RNA binding "Pf01728, Pf07780, Pf11861" 117246 ENSG00000108592.16 FTSJ3 17 Major pathway of rRNA processing in the nucleolus and cytosol 0 High P28288 ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1 0 54.212 29 15 30 15 659 75.4 9.36 7 8 10 7 11 12 794671.3125 17108166.13 16522759.96 21359380.75 1 9 10 12 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00005, Pf06472" 5825 ENSG00000117528.11 ABCD3 1 ABC transporters in lipid homeostasis Peroxisome; ABC transporters 0 High P60891 Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2 0 76.328 56 15 30 15 318 34.8 6.98 14 2 5 21 2 7 25997691.86 101955255.4 13754254.23 12385248.57 4 13 7 9 metabolic process cytosol catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00156, Pf13793, Pf14572" 5631 ENSG00000147224.10 PRPS1 X 5-Phosphoribose 1-diphosphate biosynthesis Carbon metabolism; Purine metabolism; Pentose phosphate pathway; Biosynthesis of amino acids; Metabolic pathways 0 High Q9NY93 Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1 0 100.126 55 21 30 21 547 61.6 9.26 21 1 29 1 774771.0938 153720815.5 952855.8125 1864607.998 2 17 2 4 Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf04851" 54606 ENSG00000136271.10 DDX56 7 0 High Q7L014 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2 0 45.734 18 16 30 16 1031 117.3 9.29 4 2 10 13 4 2 10 14 53135628.91 12277628.03 10989660.53 13020002.99 6 8 10 14 metabolic process;regulation of biological process cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271" 9879 ENSG00000145833.15 DDX46 5 mRNA Splicing - Major Pathway Spliceosome 0 High Q71UI9 Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AFV PE=1 SV=3 0 16.398 23 3 30 1 128 13.5 10.58 2 3 2 3 5 13 6 6 9647930.75 2377675.094 959562.4688 1 1 1 regulation of biological process chromosome;nucleus DNA binding;protein binding Pf00125 94239 ENSG00000105968.18 H2AFV 7 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Packaging Of Telomere Ends; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening Systemic lupus erythematosus; Alcoholism 0 High Q9UHX1 Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1 0 70.357 40 15 30 15 559 59.8 5.29 1 13 6 4 1 19 6 4 2715905.328 75305341.31 11766522.13 5639368.25 6 13 8 6 cell death;cellular homeostasis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 22827 ENSG00000274081.4; ENSG00000179950.13 PUF60 8; CHR_HSCHR8_3_CTG7 mRNA Splicing - Major Pathway Spliceosome 0 High P60842 Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1 0 77.68 41 13 29 11 406 46.1 5.48 8 4 6 18 4 7 215953786 39856517 6083950.688 5222501.125 3 9 7 8 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 1973 ENSG00000161960.14 EIF4A1 17 ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition RNA transport 2 High O15042 U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2 0 92.223 26 21 29 21 1029 118.2 8.47 20 3 26 3 2418695.969 71390590.31 2414546.813 1929206.9 2 18 4 6 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf01805, Pf08312, Pf13893, Pf14259" 23350 ENSG00000163714.17 U2SURP 3 mRNA Splicing - Major Pathway Spliceosome 0 High P53999 Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3 0 27.117 46 7 29 7 127 14.4 9.6 5 3 5 5 7 3 10 9 12553166.86 25499262.88 51022680.49 41344426.33 5 5 7 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf02229 10923 ENSG00000113387.11 SUB1 5 0 High Q96KG9 N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1 0 56.137 23 16 29 16 808 89.6 6.3 5 13 4 5 20 4 451238.8125 7155863.219 36425282.41 10084627.38 1 5 11 10 Acetyl [N-Term] metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00069, Pf07714" 57410 ENSG00000142186.16 SCYL1 11 0 High Q9UII4 E3 ISG15--protein ligase HERC5 OS=Homo sapiens OX=9606 GN=HERC5 PE=1 SV=2 0 112.466 34 22 29 22 1024 116.8 7.65 22 29 2941727.859 173374161.2 2185204.75 7809204.301 6 21 3 9 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;protein binding;RNA binding "Pf00415, Pf00632, Pf13540" 51191 ENSG00000138646.8 HERC5 4 ISG15 antiviral mechanism; Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling 0 High Q3KQU3 MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1 0 80.161 34 21 29 21 841 92.8 10.11 21 1 28 1 2587997.75 134342791.6 96795207 53817264.25 3 20 4 10 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol structural molecule activity 55700 ENSG00000116871.15 MAP7D1 1 0 High Q96ME7 Zinc finger protein 512 OS=Homo sapiens OX=9606 GN=ZNF512 PE=1 SV=2 0 130.335 35 15 29 15 567 64.6 9.76 14 1 28 1 12555968.75 114872480 4878880.781 3899135.75 2 14 4 3 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding 84450 ENSG00000243943.9 ZNF512 2 0 High Q15323 "Keratin, type I cuticular Ha1 OS=Homo sapiens OX=9606 GN=KRT31 PE=1 SV=3" 0 59.668 40 14 29 3 416 47.2 4.88 1 13 1 1 2 20 4 3 353475.7734 91724248.75 1681798.563 983492.3281 2 12 3 3 cell death;cell organization and biogenesis cytosol protein binding;structural molecule activity "Pf00038, Pf04156, Pf13514, Pf14362, Pf14643" 3881 ENSG00000094796.4; ENSG00000262993.1 KRT31 17; CHR_HSCHR17_1_CTG4 Formation of the cornified envelope 9 High Q8N5C6 S1 RNA-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SRBD1 PE=1 SV=2 0 86.091 24 20 28 20 995 111.7 8.72 20 1 27 1 1271760.297 136682432 2036747.453 1605338.219 2 20 3 4 metabolic process RNA binding "Pf00575, Pf09371, Pf12836, Pf14635, Pf14639" 55133 ENSG00000068784.12 SRBD1 2 0 High Q8WTT2 Nucleolar complex protein 3 homolog OS=Homo sapiens OX=9606 GN=NOC3L PE=1 SV=1 0 83.042 26 18 28 18 800 92.5 9.17 18 28 849219.4063 119205823.6 20496677.59 3355961.273 3 17 4 3 cell differentiation mitochondrion;nucleus RNA binding "Pf03914, Pf07540" 64318 ENSG00000173145.11 NOC3L 10 0 High P62987 Ubiquitin-60S ribosomal protein L40 OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2 0 39.356 40 6 28 2 128 14.7 9.83 1 3 3 3 2 18 4 4 2475.458984 218630811 1866458.422 1199148.719 1 4 2 3 cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;structural molecule activity "Pf00240, Pf01020, Pf11976, Pf13019, Pf13881, Pf14560" 7311 ENSG00000221983.7 UBA52 19 "NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits" Ribosome 0 High Q5RKV6 Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1 0 76.162 44 13 28 13 272 28.2 6.28 1 13 1 27 752435.2031 273803282.2 3916283.688 803514.3438 2 12 2 2 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;RNA binding Pf01138 118460 ENSG00000223496.2 EXOSC6 16 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High Q8NHQ9 ATP-dependent RNA helicase DDX55 OS=Homo sapiens OX=9606 GN=DDX55 PE=1 SV=3 0 98.337 42 19 28 19 600 68.5 9.25 19 28 1830209.625 108928333.4 4847761.516 4214556.444 4 18 5 6 metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf13959" 57696 ENSG00000111364.15 DDX55 12 0 High Q12797 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH PE=1 SV=3 0 76.516 24 16 27 16 758 85.8 5.01 14 1 5 21 1 5 120387.9912 75999721.42 4005132.813 5917207.145 3 14 4 6 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding;protein binding;structural molecule activity "Pf05118, Pf05279, Pf13414, Pf13428, Pf13432, Pf14559" 444 ENSG00000198363.17 ASPH 8 Ion homeostasis; Stimuli-sensing channels 0 High P38935 DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3 0 111.654 34 22 27 22 993 109.1 8.97 22 27 1308818.109 70772253 19648903.44 17969310.47 4 21 6 9 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf01424, Pf01428, Pf13086, Pf13087" 3508 ENSG00000132740.8 IGHMBP2 11 0 High Q8WVM0 "Dimethyladenosine transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TFB1M PE=1 SV=1" 0 79.2 54 15 27 15 346 39.5 9.26 15 27 881836.6719 124145847.8 753578.6328 343760.3196 3 13 2 4 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;DNA binding;protein binding;RNA binding Pf00398 51106 ENSG00000029639.10 TFB1M 6 Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion 0 High Q9NUQ6 SPATS2-like protein OS=Homo sapiens OX=9606 GN=SPATS2L PE=1 SV=2 0 110.565 42 18 27 18 558 61.7 9.64 18 27 6225740.391 97411154.63 3796247.977 3443330.715 6 17 4 6 cytoplasm;cytosol;nucleus protein binding;RNA binding Pf07139 26010 ENSG00000196141.13 SPATS2L 2 0 High O75179 Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3 0 90.67 12 24 27 17 2603 274.1 6.52 24 27 1790478.867 77709193.56 2212638.406 4505709.696 4 21 2 10 defense response;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus protein binding;RNA binding "Pf00013, Pf00023, Pf05109, Pf07223, Pf12796, Pf13014, Pf13606, Pf13637, Pf13857" 26057 ENSG00000132466.18 ANKRD17 4 7 High P78346 Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1 0 93.49 65 14 27 14 268 29.3 8.91 14 2 25 2 4230141.992 124942494.6 783654.9546 321077.0542 5 14 3 5 Met-loss+Acetyl [N-Term] metabolic process nucleus catalytic activity;protein binding;RNA binding Pf01876 10556 ENSG00000148688.13 RPP30 10 Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High Q9UQ80 Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3 0 79.193 46 17 27 17 394 43.8 6.55 17 27 476731.3486 142034529.3 1117489.453 1277626.983 4 15 4 5 cell proliferation;metabolic process;regulation of biological process;transport cytoplasm;extracellular;membrane;nucleus;organelle lumen DNA binding;protein binding;RNA binding Pf00557 5036 ENSG00000170515.13 PA2G4 12 Neutrophil degranulation 0 High P14678 Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2 0 54.879 28 9 27 9 240 24.6 11.19 1 9 3 2 1 19 4 3 3018443.875 117020306.8 5840116.938 5339783.219 2 9 4 5 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6628 ENSG00000125835.18 SNRPB 20 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome; Systemic lupus erythematosus 0 High Q96C57 Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2 0 131.589 58 11 27 11 262 28.2 9.42 11 1 26 1 291975.5625 73464654.5 2904244.219 1502416.859 2 11 4 3 protein binding 64897 ENSG00000157895.11 C12orf43 12 0 High Q14137 Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2 0 92.078 34 20 27 20 746 83.6 6.19 20 27 2235.5354 365033324.8 870713.2188 8434.392578 1 15 3 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process nucleus protein binding;RNA binding "Pf00400, Pf08145" 23246 ENSG00000261236.7 BOP1 8 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q9H5H4 Zinc finger protein 768 OS=Homo sapiens OX=9606 GN=ZNF768 PE=1 SV=2 0 87.273 32 16 27 16 540 60.2 7.97 16 27 2482775.234 234416232.1 4480413.484 1240136.281 3 15 5 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;RNA binding "Pf00096, Pf07282, Pf13465, Pf14353" 79724 ENSG00000169957.9 ZNF768 16 0 High O43395 U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2 0 91.36 36 18 27 18 683 77.5 9.5 18 27 2417384 84652672.38 202052.9531 246966.9844 1 17 1 3 cell organization and biogenesis;metabolic process cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf01480, Pf06544, Pf08572" 9129 ENSG00000117360.12 PRPF3 1 mRNA Splicing - Major Pathway Spliceosome 0 High P62314 Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1 0 46.789 55 4 27 4 119 13.3 11.56 1 4 2 2 2 17 3 5 1477452.708 119633364.8 8686824.188 4933258.406 2 5 3 4 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6632 ENSG00000167088.10 SNRPD1 18 snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Systemic lupus erythematosus 0 High P26641 Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3 0 28.253 18 7 27 7 437 50.1 6.67 3 3 5 5 5 6 9 7 1741257.719 10916161.31 12714246.06 9318394.938 3 4 5 5 metabolic process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00043, Pf00647, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497" 1937 ENSG00000254772.9 EEF1G 11 Eukaryotic Translation Elongation Legionellosis 0 High Q9BSC4 Nucleolar protein 10 OS=Homo sapiens OX=9606 GN=NOL10 PE=1 SV=1 0 89.686 32 16 27 16 688 80.3 8.46 16 1 26 1 3510175.914 112286881.6 2514138.31 1301589.794 3 15 4 4 nucleus protein binding;RNA binding Pf08159 79954 ENSG00000115761.15 NOL10 2 0 High Q9BVJ6 U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1 0 93.144 28 18 26 18 771 87.9 7.87 18 26 503317.2344 98709323.75 2778212.037 2545150.719 3 18 6 5 metabolic process cytosol;nucleus protein binding;RNA binding Pf04615 10813 ENSG00000156697.12 UTP14A X Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9BYP7 Serine/threonine-protein kinase WNK3 OS=Homo sapiens OX=9606 GN=WNK3 PE=1 SV=3 0 62.67 15 19 26 17 1800 198.3 6.07 1 19 2 1 23 2 127196.9063 7805264.875 42449979.38 11667308.52 1 5 14 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12202" 65267 ENSG00000196632.10 WNK3 X Stimuli-sensing channels 2 High P08579 U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1 0 58.119 47 9 26 7 225 25.5 9.72 9 2 1 23 2 1 3039514.828 234953640.9 4795914.367 5754839.809 4 10 5 7 Acetyl [N-Term] metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6629 ENSG00000125870.10 SNRPB2 20 mRNA Splicing - Major Pathway Spliceosome 2 High Q96MX3 Zinc finger protein 48 OS=Homo sapiens OX=9606 GN=ZNF48 PE=1 SV=2 0 89.277 45 17 26 16 618 67.8 9.36 17 26 127205464.6 65158932.5 910188.875 1110131.922 6 14 2 4 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 197407 ENSG00000180035.12 ZNF48 16 0 High P51398 "28S ribosomal protein S29, mitochondrial OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" 0 85.542 42 14 26 14 398 45.5 8.88 14 26 1451807.625 138369469.1 1176289.5 2335662.405 4 13 4 5 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;ribosome nucleotide binding;protein binding;RNA binding;structural molecule activity Pf10236 7818 ENSG00000132676.15 DAP3 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High O60293 Zinc finger C3H1 domain-containing protein OS=Homo sapiens OX=9606 GN=ZFC3H1 PE=1 SV=3 0 89.136 15 22 26 22 1989 226.2 8.13 22 26 6269067.336 59286074.63 3750892.293 1668884.531 7 19 6 5 metabolic process nucleus metal ion binding;protein binding;RNA binding "Pf08317, Pf10650, Pf13414, Pf14559" 196441 ENSG00000133858.15 ZFC3H1 12 0 High Q92922 SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3 0 44.828 11 9 26 5 1105 122.8 5.76 4 2 6 8 4 2 9 11 3978503.641 10006426.25 10798652.91 10809508.94 7 3 7 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding Pf04433 6599 ENSG00000173473.10 SMARCC1 3 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 4 High Q01844 RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1 0 59.226 14 7 26 7 656 68.4 9.33 1 6 5 3 1 13 8 4 2017020.875 45883935.69 17484977.75 8305876.75 2 7 4 5 metabolic process;regulation of biological process cytoplasm;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf14259" 2130 ENSG00000182944.17 EWSR1 22 Transcriptional misregulation in cancer 0 High Q969P6 "DNA topoisomerase I, mitochondrial OS=Homo sapiens OX=9606 GN=TOP1MT PE=1 SV=1" 0 24.146 13 8 26 2 601 69.8 9.41 8 3 23 3 1036334.5 1 cell organization and biogenesis;metabolic process chromosome;mitochondrion;nucleus catalytic activity;DNA binding "Pf01028, Pf02919, Pf14370" 116447 ENSG00000184428.12 TOP1MT 8 0 High P62273 40S ribosomal protein S29 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2 0 24.472 50 4 25 4 56 6.7 10.13 4 3 2 19 3 3 3423345.156 933751114.6 10345210.5 2294984.469 2 8 3 2 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome metal ion binding;structural molecule activity Pf00253 6235 ENSG00000213741.9 RPS29 14 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High O15446 DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=CD3EAP PE=1 SV=1 0 104.645 54 14 25 14 510 55 8.51 14 25 108034974.8 2506294.914 2118375.5 13 3 3 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;mitochondrion;nucleus catalytic activity;RNA binding Pf08208 10849 ENSG00000117877.10 CD3EAP 19 RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation 0 High P57721 Poly(rC)-binding protein 3 OS=Homo sapiens OX=9606 GN=PCBP3 PE=2 SV=2 0 26.829 15 4 25 1 371 39.4 8.07 3 3 4 3 5 8 6 6 543886.4375 500633.4375 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus DNA binding;RNA binding "Pf00013, Pf13014" 54039 ENSG00000183570.16 PCBP3 21 0 High Q8IZD2 Inactive histone-lysine N-methyltransferase 2E OS=Homo sapiens OX=9606 GN=KMT2E PE=1 SV=1 0 59.559 11 16 25 16 1858 204.8 7.61 9 10 13 12 2720748.659 1604209.625 10257632.56 11462797.75 4 2 8 10 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00628, Pf00856, Pf07223, Pf09770" 55904 ENSG00000005483.20 KMT2E; MLL5 7 PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Lysine degradation 0 High Q96GA3 Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1 0 90.64 42 16 25 16 475 54.8 4.91 16 25 2377487.625 73206885.75 3541714.799 3298947.219 4 16 6 5 metabolic process;transport cytosol;membrane;nucleus protein binding Pf04180 84946 ENSG00000135521.8 LTV1 6 Major pathway of rRNA processing in the nucleolus and cytosol 0 High O94898 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens OX=9606 GN=LRIG2 PE=2 SV=3 0 51.853 20 16 25 15 1065 118.9 5.55 3 16 3 22 618367.5156 5875827.5 14406743.81 31897608 2 6 12 14 regulation of biological process cytoplasm;membrane protein binding "Pf00047, Pf07679, Pf07686, Pf12799, Pf13306, Pf13855, Pf13895, Pf13927" 9860 ENSG00000198799.11 LRIG2 1 1 High Q14525 "Keratin, type I cuticular Ha3-II OS=Homo sapiens OX=9606 GN=KRT33B PE=1 SV=3" 0 54.761 37 10 25 1 404 46.2 4.84 1 9 1 1 2 16 4 3 cell death;transport cytosol;membrane catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf00529, Pf01576, Pf04156, Pf13514, Pf14362" 3884 ENSG00000263012.1; ENSG00000131738.10 KRT33B 17; CHR_HSCHR17_1_CTG4 Formation of the cornified envelope 0 High Q9Y3C1 Nucleolar protein 16 OS=Homo sapiens OX=9606 GN=NOP16 PE=1 SV=2 0 70.573 58 11 25 11 178 21.2 9.94 11 25 162281587.1 520214521.3 20123551.47 146149303.1 3 11 2 4 nucleus RNA binding Pf09420 51491 ENSG00000048162.20 NOP16 5 0 High Q9Y2R4 Probable ATP-dependent RNA helicase DDX52 OS=Homo sapiens OX=9606 GN=DDX52 PE=1 SV=3 0 118.595 42 18 25 17 599 67.5 9.67 18 25 1176864.891 114774280 3429997.875 1396385.727 4 14 3 3 Acetyl [N-Term] metabolic process cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;RNA binding "Pf00176, Pf00270, Pf00271, Pf04851, Pf13307" 11056 ENSG00000277594.2 DDX52 17; CHR_HSCHR17_7_CTG4 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q86XZ4 Spermatogenesis-associated serine-rich protein 2 OS=Homo sapiens OX=9606 GN=SPATS2 PE=1 SV=1 0 96.202 47 15 25 15 545 59.5 8.9 15 25 557790.6406 65145503.25 831139.5938 3263482.153 2 15 2 3 cytoplasm;cytosol protein binding;RNA binding Pf07139 65244 ENSG00000123352.17 SPATS2 12 0 High Q15029 116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1 0 68.56 23 17 25 16 972 109.4 5 11 5 5 14 6 5 3302194.375 153597852 9156197.094 6327600.805 5 10 9 10 cell organization and biogenesis;metabolic process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 9343 ENSG00000108883.12 EFTUD2 17 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High P40939 "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" 0 44.73 21 14 25 14 763 82.9 9.04 5 6 8 3 5 7 10 3 2646532.656 28501774.06 16196658.56 9459625.508 7 7 8 9 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00378, Pf00725, Pf02737" 3030 ENSG00000084754.10 HADHA 2 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Butanoate metabolism; Fatty acid degradation; Propanoate metabolism; Carbon metabolism; Lysine degradation; beta-Alanine metabolism; Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 High Q9BRT6 Protein LLP homolog OS=Homo sapiens OX=9606 GN=LLPH PE=1 SV=1 0 68.884 46 6 24 6 129 15.2 10.37 6 24 390177.8125 169816606.9 1326103.844 3789689.5 1 6 2 2 cell growth;regulation of biological process chromosome;nucleus protein binding;RNA binding Pf10169 84298 ENSG00000139233.6 LLPH 12 0 High Q96EY4 Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2 0 57.119 44 11 24 11 203 23.8 9.26 11 1 23 1 120188.375 222950738.3 2486249.07 272429.9297 1 11 3 2 nucleus;ribosome protein binding Pf11176 55319 ENSG00000198498.9 TMA16 4 0 High Q9Y2R9 "28S ribosomal protein S7, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" 0 78.168 51 13 24 13 242 28.1 9.99 13 1 1 22 1 1 183334048.4 3543126.281 2722014.109 13 4 5 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00177 51081 ENSG00000125445.10 MRPS7 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q96KR1 Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2 0 115.434 23 18 24 18 1074 116.9 9.04 18 1 23 1 6379062.25 110926025.8 560521.75 3 16 1 Acetyl [N-Term] development chromosome;cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf07528, Pf12171, Pf12874" 51663 ENSG00000056097.15 ZFR 5 0 High O43175 D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4 0 37.079 24 11 24 11 533 56.6 6.71 3 9 6 3 12 9 941506.3125 9789750.625 18854110.06 17045838.79 1 6 11 11 metabolic process cytosol catalytic activity;nucleotide binding "Pf00389, Pf02826" 26227 ENSG00000092621.11 PHGDH 1 Serine biosynthesis "Carbon metabolism; Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Metabolic pathways" 0 High Q15369 Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1 0 54.539 66 7 24 7 112 12.5 4.78 3 6 3 3 5 9 5 5 3869724.891 50377291 14279414.5 10991197.16 4 7 4 4 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;protein binding;RNA binding Pf03931 6921 ENSG00000154582.16 TCEB1; ELOC 8 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-7 signaling; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of Tat-mediated HIV elongation HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma 0 High Q96AG4 Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1 0 42.64 35 10 24 10 307 34.9 9.57 2 8 4 6 2 10 4 8 2365217.641 122741455.2 32848313.15 40492106.58 3 9 6 6 endoplasmic reticulum;membrane;nucleus protein binding;RNA binding "Pf12799, Pf13855" 55379 ENSG00000108829.9 LRRC59 17 0 High O60287 Nucleolar pre-ribosomal-associated protein 1 OS=Homo sapiens OX=9606 GN=URB1 PE=1 SV=4 0 93.277 12 19 24 19 2271 254.2 6.47 19 24 1591784 43909178.34 542950.0625 7580007.27 1 14 1 5 nucleus RNA binding Pf11707 9875 ENSG00000142207.6 URB1 21 0 High Q9BT22 Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG1 PE=1 SV=2 0 38.188 20 7 24 7 464 52.5 7.23 1 5 7 1 12 11 419975.625 12685480.06 43837011.63 37267796.38 1 3 6 7 metabolic process endoplasmic reticulum;membrane catalytic activity "Pf00534, Pf13692" 56052 ENSG00000033011.11 ALG1 16 "Defective ALG1 causes ALG1-CDG (CDG-1k); Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" N-Glycan biosynthesis; Metabolic pathways 0 High Q14204 Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5 0 37.76 4 18 24 18 4646 532.1 6.4 10 5 5 12 7 5 10555210.06 118706273 6944976.719 4641789.987 10 6 9 9 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00769, Pf03028, Pf03915, Pf04156, Pf07246, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13173, Pf13207, Pf13401" 1778 ENSG00000197102.10 DYNC1H1 14 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High P34896 "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" 0 48.769 44 17 24 17 483 53 7.71 17 24 44531481.86 2811474.5 55853.17236 75079.55127 14 3 2 5 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding;RNA binding;translation regulator activity Pf00464 6470 ENSG00000176974.19 SHMT1 17 Metabolism of folate and pterines; Carnitine synthesis "Carbon metabolism; Glycine, serine and threonine metabolism; Antifolate resistance; Biosynthesis of amino acids; One carbon pool by folate; Metabolic pathways; Glyoxylate and dicarboxylate metabolism" 0 High Q9H501 ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1 0 84.738 25 16 24 16 851 98.7 5.11 16 24 387268.5399 59456545.38 151116.5781 1687712.232 2 15 1 4 metabolic process;regulation of biological process nucleus RNA binding Pf08159 51575 ENSG00000089048.14 ESF1 20 0 High O75569 Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1 0 90.159 48 11 24 11 313 34.4 8.41 11 1 23 1 165052922 2041596.094 909944.5625 10 4 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf00035, Pf14709" 8575 ENSG00000180228.12 PRKRA 2 MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis 0 High Q14697 Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3 0 43.527 19 15 24 15 944 106.8 6.14 3 13 4 20 261681.0806 19021620.75 7370105.047 25229978.22 2 5 10 15 metabolic process endoplasmic reticulum;Golgi;membrane;organelle lumen catalytic activity;RNA binding "Pf01055, Pf13802" 23193 ENSG00000089597.16 GANAB 11 Calnexin/calreticulin cycle N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q9UKD2 mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2 0 60.471 59 15 24 15 239 27.5 8.29 14 2 3 19 2 3 3249612.547 179339025.5 2531308.688 1287098.66 3 15 3 5 cell organization and biogenesis;metabolic process cytoplasm;nucleus protein binding;RNA binding Pf00466 51154 ENSG00000053372.4 MRTO4 1 0 High P33993 DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4 0 39.785 19 12 24 12 719 81.3 6.46 2 6 10 2 8 14 21365119.13 13292220.69 12800750.41 5 9 9 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 4176 ENSG00000166508.17 MCM7 7 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High P62857 40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1 0 30.517 71 5 24 5 69 7.8 10.7 1 5 2 1 2 19 2 1 1597707.416 860031686.4 10191954.59 4650608.174 2 7 3 4 Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome protein binding;RNA binding;structural molecule activity Pf01200 6234 ENSG00000233927.4 RPS28 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P50991 T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4 0 34.021 27 12 24 11 539 57.9 7.83 2 6 9 2 9 13 161556.4023 2905522.591 9013409.313 10076278.81 2 3 7 9 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 10575 ENSG00000115484.14 CCT4 2 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High Q15269 Periodic tryptophan protein 2 homolog OS=Homo sapiens OX=9606 GN=PWP2 PE=2 SV=2 0 75.904 20 16 24 16 919 102.4 6.15 16 1 23 1 915791.0625 113527833 1206278.813 1634162.836 1 14 3 2 cell organization and biogenesis;metabolic process nucleus protein binding;RNA binding "Pf00400, Pf04003" 5822; 102724159 ENSG00000241945.7 PWP2; LOC102724159 21 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9Y221 60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1 0 71.212 79 10 24 10 180 20.4 8.51 10 1 23 1 625838.6875 204939106.8 1984141.461 548068.5742 2 9 4 3 cell organization and biogenesis cytosol;nucleus protein binding;RNA binding Pf03657 51388 ENSG00000132603.13 NIP7 16 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q9UJA5 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1 0 66.552 42 16 24 16 497 55.8 7.55 16 24 14130.4873 61101187.13 526792.125 553172.8984 1 14 1 3 Acetyl [N-Term] metabolic process nucleus RNA binding Pf04189 51605 ENSG00000089195.14 TRMT6 20 tRNA modification in the nucleus and cytosol 0 High Q9Y3D9 "28S ribosomal protein S23, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" 0 96.116 58 12 24 12 190 21.8 8.9 12 1 1 22 1 1 994073.1133 85138751.13 1260343.158 1959740.979 4 9 3 5 cell organization and biogenesis;metabolic process cytoskeleton;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity "Pf10484, Pf13741" 51649 ENSG00000181610.12 MRPS23 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q13243 Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1 0 42.674 33 10 24 9 272 31.2 11.59 1 10 2 2 20 2 616633.2656 201122825.8 2479466.352 1681276.064 2 8 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6430 ENSG00000100650.15 SRSF5 14 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 0 High O95819 Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2 0 42.372 16 14 24 14 1239 142 7.46 2 12 3 2 3 15 4 2 1680912.469 518023289.5 6215171.375 3446629.438 3 9 4 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00780, Pf07714" 9448 ENSG00000071054.16 MAP4K4 2 Oxidative Stress Induced Senescence MAPK signaling pathway 0 High O95985 DNA topoisomerase 3-beta-1 OS=Homo sapiens OX=9606 GN=TOP3B PE=1 SV=1 0 96.171 28 18 23 17 862 96.6 8.12 18 23 1334533.813 76754310.63 2770844.508 1800860.707 4 19 4 7 metabolic process chromosome;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf01131, Pf01751" 8940 ENSG00000100038.19 TOP3B 22 Homologous recombination; Fanconi anemia pathway 1 High Q49A26 Putative oxidoreductase GLYR1 OS=Homo sapiens OX=9606 GN=GLYR1 PE=1 SV=4 0 69.681 42 15 23 15 553 60.5 9.17 15 23 953219.0234 50488662.19 156080.0625 3 12 1 metabolic process chromosome;cytosol;Golgi catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00855, Pf02737, Pf03446, Pf03807, Pf14833" 84656 ENSG00000140632.16 GLYR1 16 0 High E9PRG8 Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11ORF98 PE=4 SV=2 0 38.113 47 8 23 8 123 14.2 11.53 8 1 1 21 1 1 2479.90332 321402877.1 23950967 11441083.51 1 9 4 5 0 High Q92804 TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1 0 22.949 19 6 23 4 592 61.8 8.02 2 4 2 5 3 8 3 9 6155712.696 5545222.125 6934112.25 4166210.125 3 2 2 3 regulation of biological process cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf13893, Pf14259" 8148 ENSG00000270647.5; ENSG00000276833.2 TAF15 17; CHR_HSCHR17_7_CTG4 Basal transcription factors; Transcriptional misregulation in cancer 0 High P62316 Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1 0 39.649 62 7 23 7 118 13.5 9.91 7 2 2 17 2 4 3537402.617 132678423.3 3981615.563 17002223.81 2 7 4 5 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6633 ENSG00000125743.10 SNRPD2 19 snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9HBE1 "POZ-, AT hook-, and zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=PATZ1 PE=1 SV=1" 0 82.779 30 16 23 14 687 74 8.35 16 23 473283.8438 90225767.75 1910096.188 3786444.141 1 16 2 5 cell differentiation;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00651, Pf13465" 23598 ENSG00000100105.17 PATZ1 22 2 High Q13724 Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5 0 78.823 28 16 23 16 837 91.9 8.9 15 5 18 5 2485356.844 47109730.63 4175155.063 6789459.231 3 14 3 6 metabolic process endoplasmic reticulum;membrane catalytic activity Pf03200 7841 ENSG00000115275.11 MOGS 2 Defective MOGS causes MOGS-CDG (CDG-2b); N-glycan trimming in the ER and Calnexin/Calreticulin cycle N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High O60568 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1 0 26.308 15 9 23 9 738 84.7 6.05 1 3 7 6 1 3 11 8 743063.8594 4989925.625 10814177.69 12555363.95 2 3 7 8 cell organization and biogenesis;metabolic process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;protein binding Pf03171 8985 ENSG00000106397.11 PLOD3 7 Collagen biosynthesis and modifying enzymes Lysine degradation; Other types of O-glycan biosynthesis 0 High P82933 "28S ribosomal protein S9, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" 0 67.982 38 15 23 15 396 45.8 9.51 15 1 1 20 2 1 2173427.563 99734124.38 5455681.918 1720723.961 2 13 7 8 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00380 64965 ENSG00000135972.8 MRPS9 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9UBU9 Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1 0 71.078 36 18 23 18 619 70.1 8.51 18 23 245420.5664 103378623.8 2977357.563 2385721.957 2 15 2 5 transport cytoplasm;cytosol;nucleus protein binding;RNA binding;transporter activity "Pf02136, Pf03943, Pf09162, Pf12799" 10482 ENSG00000162231.13 NXF1 11 Transport of the SLBP independent Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA Ribosome biogenesis in eukaryotes; mRNA surveillance pathway; RNA transport; Herpes simplex infection; Influenza A 0 High P78386 "Keratin, type II cuticular Hb5 OS=Homo sapiens OX=9606 GN=KRT85 PE=1 SV=1" 0 61.036 34 15 23 7 507 55.8 6.55 14 1 22 1 116977.1025 38530917.75 4556279.68 3668724.266 2 8 4 4 cell death cytosol structural molecule activity "Pf00038, Pf09726" 3891 ENSG00000135443.8 KRT85 12 Formation of the cornified envelope 1 High Q9H8H2 Probable ATP-dependent RNA helicase DDX31 OS=Homo sapiens OX=9606 GN=DDX31 PE=1 SV=2 0 78.839 28 19 23 19 851 94 9.99 19 23 570573.5625 126506368.9 1122944.27 1654240.519 3 19 3 7 metabolic process cytoplasm;Golgi;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851, Pf13959" 64794 ENSG00000125485.17 DDX31 9 0 High Q5VWQ0 Lysine-specific demethylase 9 OS=Homo sapiens OX=9606 GN=RSBN1 PE=1 SV=2 0 92.543 26 15 23 14 802 90 8.6 15 23 883266.6953 47083149.75 9269186 11306672.34 4 12 1 3 nucleus 54665 ENSG00000081019.13 RSBN1 1 0 High Q96GQ7 Probable ATP-dependent RNA helicase DDX27 OS=Homo sapiens OX=9606 GN=DDX27 PE=1 SV=2 0 64.291 19 15 23 15 796 89.8 9.28 15 23 1845222.438 95876146.75 3343798.375 1084684.39 3 14 4 4 metabolic process chromosome;cytoplasm;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf06862" 55661 ENSG00000124228.14 DDX27 20 0 High Q8WUA4 General transcription factor 3C polypeptide 2 OS=Homo sapiens OX=9606 GN=GTF3C2 PE=1 SV=2 0 65.025 23 14 23 14 911 100.6 7.31 13 2 21 2 1060405.031 48543612.69 3981448.469 1425875.698 2 10 4 3 metabolic process nucleus DNA binding;protein binding Pf00400 2976 ENSG00000115207.13 GTF3C2 2 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 High Q8IWC1 MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2 0 81.32 25 19 23 19 876 98.4 9.32 19 23 134019.2188 75420846.06 211443.2969 1 16 1 cell organization and biogenesis cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity Pf15479 79649 ENSG00000129680.15 MAP7D3 X 0 High Q86X95 Corepressor interacting with RBPJ 1 OS=Homo sapiens OX=9606 GN=CIR1 PE=1 SV=1 0 25.773 22 11 23 11 450 52.3 9.86 2 3 3 9 3 4 5 11 2963381.328 19439661.25 6904835.188 14055170.56 2 5 4 8 metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus protein binding Pf10197 9541 ENSG00000138433.15 CIR1 2 Notch signaling pathway 0 High O60524 Nuclear export mediator factor NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4 0 67.84 20 17 23 17 1076 122.9 6.35 17 23 275156.2705 83656033.53 187986.7031 1075759.563 2 15 1 4 transport nucleus "Pf05670, Pf05833, Pf11923" 9147 ENSG00000165525.17 NEMF 14 0 High P63167 "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" 0 33.233 57 4 23 4 89 10.4 7.4 3 4 3 2 5 12 4 2 7085655 101135207.2 7151856.656 4764236.5 3 4 3 2 cell communication;cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding Pf01221 8655 ENSG00000088986.10 DYNLL1 12 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Activation of BIM and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; MHC class II antigen presentation; Macroautophagy Vasopressin-regulated water reabsorption 0 High P05023 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1 0 48.323 18 15 23 15 1023 112.8 5.49 1 5 13 1 5 17 3022704.293 4813648.5 9837868.672 20272789.5 3 2 8 13 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 476 ENSG00000163399.15 ATP1A1 1 Ion homeostasis; Ion transport by P-type ATPases Bile secretion; cGMP-PKG signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Protein digestion and absorption; Proximal tubule bicarbonate reclamation; Thyroid hormone signaling pathway; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Pancreatic secretion; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Gastric acid secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Mineral absorption 0 High P38919 Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4 0 82.604 39 12 23 10 411 46.8 6.73 12 1 1 21 1 1 526404.8438 62898854.5 1115558.031 485925.4375 1 10 3 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 9775 ENSG00000141543.9 EIF4A3 17 ISG15 antiviral mechanism; mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA Spliceosome; mRNA surveillance pathway; RNA transport 0 High P04406 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3 0 36.518 30 8 22 8 335 36 8.46 2 1 6 6 2 1 10 9 940277.5313 4883796.188 19337151.88 12645563.19 2 3 6 7 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00044, Pf02800" 2597 ENSG00000111640.14 GAPDH 12 Gluconeogenesis; Glycolysis HIF-1 signaling pathway; Carbon metabolism; Alzheimer's disease; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 High Q9BXS6 Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1 0 76.836 49 17 22 17 441 49.4 9.91 17 22 913411.6563 288752009.6 3782580.188 4344447.797 3 15 5 5 cell division;cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;cytoskeleton;nucleus DNA binding;protein binding;RNA binding 51203 ENSG00000137804.12 NUSAP1 15 0 High Q13601 KRR1 small subunit processome component homolog OS=Homo sapiens OX=9606 GN=KRR1 PE=1 SV=4 0 84.466 37 11 22 11 381 43.6 9.77 11 22 3042644.469 127387331.6 9602064.375 10231172.87 3 12 5 7 metabolic process cytoplasm;membrane;nucleus protein binding;RNA binding Pf00013 11103 ENSG00000111615.13 KRR1 12 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q9UBS9 SUN domain-containing ossification factor OS=Homo sapiens OX=9606 GN=SUCO PE=1 SV=1 0 34.175 13 11 22 11 1254 139.3 5.01 2 8 5 2 15 5 418589.5313 20836746.75 27714156.06 7991802.531 1 4 7 8 development;regulation of biological process endoplasmic reticulum;membrane "Pf07738, Pf12004" 51430 ENSG00000094975.13 SUCO 1 0 High Q9ULM3 YEATS domain-containing protein 2 OS=Homo sapiens OX=9606 GN=YEATS2 PE=1 SV=2 0 42.006 14 14 22 14 1422 150.7 8.98 2 12 4 2 16 4 108661647.6 22939294.66 16147362.98 5 12 10 cell organization and biogenesis;metabolic process;regulation of biological process nucleus protein binding Pf03366 55689 ENSG00000163872.15 YEATS2 3 HATs acetylate histones 0 High P04843 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1 0 43.632 27 12 22 12 607 68.5 6.38 1 7 10 1 8 13 2637934.227 7588460.625 27194256.38 40745278.38 6 3 9 12 metabolic process cytosol;endoplasmic reticulum;membrane catalytic activity;protein binding;RNA binding Pf04597 6184 ENSG00000163902.11 RPN1 3 Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q71RC2 La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3 0 85.514 28 14 22 12 724 80.5 6.61 14 22 279532.3779 58729912.66 2806676 1276560.813 2 13 3 4 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding "Pf05383, Pf14259" 113251 ENSG00000161813.21 LARP4 12 2 High Q92945 Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4 0 41.778 20 10 22 10 711 73.1 7.3 2 7 3 5 3 8 4 7 3648784.813 13193929.19 6073744.563 8993993.625 5 5 5 6 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf07650, Pf09005, Pf13014" 8570 ENSG00000088247.17 KHSRP 19 ATF4 activates genes; KSRP (KHSRP) binds and destabilizes mRNA 0 High Q71DI3 Histone H3.2 OS=Homo sapiens OX=9606 GN=HIST2H3A PE=1 SV=3 0 42.916 52 6 22 1 136 15.4 11.27 6 1 3 16 1 5 2009780.875 11410267 1 2 cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;nucleus DNA binding;protein binding Pf00125 333932; 126961; 653604 ENSG00000203852.3; ENSG00000183598.3; ENSG00000203811.1 HIST2H3A; HIST2H3C; HIST2H3D 1 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Interleukin-7 signaling; Factors involved in megakaryocyte development and platelet production; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Transcriptional misregulation in cancer; Systemic lupus erythematosus; Alcoholism 0 High Q5SY16 Polynucleotide 5'-hydroxyl-kinase NOL9 OS=Homo sapiens OX=9606 GN=NOL9 PE=1 SV=1 0 77.562 25 12 22 12 702 79.3 9.13 1 12 1 21 768902.6484 133041472.1 82056.19556 2 12 4 metabolic process cytoskeleton;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf03205, Pf06807" 79707 ENSG00000162408.10 NOL9 1 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q13123 Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3 0 70.124 34 17 22 17 557 65.6 6.64 17 1 21 1 64863194.88 1662956.641 1576821.021 16 4 5 metabolic process;regulation of biological process chromosome;cytoplasm;cytoskeleton;nucleus;spliceosomal complex protein binding "Pf07807, Pf07808" 3550 ENSG00000113141.17 IK 5 0 High Q15014 Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1 0 64.785 51 12 22 12 288 32.3 9.72 1 12 1 21 595161.2813 106064735.2 2 12 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding Pf05712 9643 ENSG00000123562.16 MORF4L2 X HATs acetylate histones 0 High Q16880 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Homo sapiens OX=9606 GN=UGT8 PE=2 SV=2 0 43.848 26 14 22 13 541 61.4 9.52 1 14 2 20 147072.3906 12877832.06 3613795.938 31296964.75 1 5 6 13 cell organization and biogenesis;metabolic process membrane catalytic activity "Pf00201, Pf04101" 7368 ENSG00000174607.10 UGT8 4 Glycosphingolipid metabolism Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways 0 High P35659 Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1 0 42.059 26 10 22 10 375 42.6 8.56 1 9 2 2 1 17 2 2 247779.0156 92548240.25 9536062.875 8436683.469 1 10 7 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding;RNA binding "Pf02037, Pf08766" 7913 ENSG00000124795.14 DEK 6 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; B-WICH complex positively regulates rRNA expression 0 High Q9H9Y6 DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2 0 80.986 22 19 22 18 1135 128.1 7.83 19 1 21 1 3573972.854 66277934.25 16558019.18 15101520.38 7 18 5 5 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04567, Pf06883" 84172 ENSG00000125630.15 POLR1B 2 RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation Purine metabolism; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 1 High Q03701 CCAAT/enhancer-binding protein zeta OS=Homo sapiens OX=9606 GN=CEBPZ PE=1 SV=3 0 78.882 17 13 21 13 1054 120.9 5.94 13 21 1193999.75 69585946.38 479091.0557 1309636.25 3 13 2 3 metabolic process;regulation of biological process nucleus DNA binding;RNA binding Pf03914 10153 ENSG00000115816.14 CEBPZ 2 0 High Q52LJ0 Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2 0 43.324 20 7 21 4 433 45.5 8.69 2 4 4 3 2 12 4 3 267413.2188 3309210.375 3061214.031 1482299.656 1 2 4 3 0 High O76009 "Keratin, type I cuticular Ha3-I OS=Homo sapiens OX=9606 GN=KRT33A PE=2 SV=2" 0 54.359 34 12 21 3 404 45.9 4.82 12 21 101932.1797 18291269.5 655320.3125 1 3 2 cell death;metabolic process cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf04156, Pf07888, Pf12128, Pf13166, Pf13514, Pf14362" 3883 ENSG00000006059.3; ENSG00000261986.1 KRT33A 17; CHR_HSCHR17_1_CTG4 Formation of the cornified envelope 1 High Q7RTS7 "Keratin, type II cytoskeletal 74 OS=Homo sapiens OX=9606 GN=KRT74 PE=1 SV=2" 0 12.265 5 4 21 1 529 57.8 7.71 2 2 4 3 7 2 5 7 1802067.5 925250.8125 1 1 cell death;cell organization and biogenesis cytoplasm;cytosol protein binding;structural molecule activity Pf00038 121391 ENSG00000170484.9 KRT74 12 Formation of the cornified envelope 0 High P04844 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3 0 48.076 25 10 21 10 631 69.2 5.69 4 9 5 16 1402690 7001527.375 22284662.39 1 4 9 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;protein binding Pf05817 6185 ENSG00000118705.16 RPN2 20 Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q5T749 Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1 0 36.238 23 7 21 7 579 64.1 8.27 4 4 4 6 7 8 5132535.25 2048361.063 8246798.031 7289637.563 4 1 4 4 cytoplasm protein binding 448834 ENSG00000203786.6 KPRP 1 0 High Q9GZR2 RNA exonuclease 4 OS=Homo sapiens OX=9606 GN=REXO4 PE=1 SV=2 0 75.062 42 15 21 15 422 46.6 9.77 15 21 9497328.859 91305227.75 4806086.406 3692242.211 4 15 2 3 metabolic process;regulation of biological process nucleus catalytic activity;RNA binding Pf00929 57109 ENSG00000280706.2; ENSG00000148300.11 REXO4 9; CHR_HG2030_PATCH 0 High Q96P11 Probable 28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2 0 69.508 46 14 21 14 429 46.7 8.62 14 21 7058158.016 61948611.38 1471.731567 723495.8613 5 14 1 3 Met-loss+Acetyl [N-Term] metabolic process nucleus catalytic activity;RNA binding Pf01189 55695 ENSG00000130305.16 NSUN5 7 0 High Q9BY77 Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2 0 61.452 44 13 21 13 421 46.1 9.99 13 1 20 1 109139159.6 8400333.352 6753274.93 13 4 4 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 84271 ENSG00000100227.17 POLDIP3 22 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing 0 High P84090 Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1 0 35.393 56 5 21 5 104 12.3 5.92 2 5 3 2 2 12 4 3 2413378.516 157209168.9 13480280.19 6475051.016 3 5 4 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process DNA binding;nucleotide binding;protein binding;RNA binding Pf01133 2079 ENSG00000100632.10 ERH 14 0 High Q6ZNE5 Beclin 1-associated autophagy-related key regulator OS=Homo sapiens OX=9606 GN=ATG14 PE=1 SV=1 0 48.216 28 11 21 11 492 55.3 7.01 2 4 10 2 6 13 1155490.5 11356206.84 36608419.63 45487143.59 1 4 4 8 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;vacuole protein binding "Pf06785, Pf10186" 22863 ENSG00000126775.8 ATG14 14 Macroautophagy; Interleukin-7 signaling Autophagy 0 High P12004 Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1 0 27.007 30 8 21 8 261 28.8 4.69 1 3 5 7 1 5 5 10 7957616.297 12808302.58 8632258.75 16957027.19 3 5 5 8 cell differentiation;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding "Pf00705, Pf02747" 5111 ENSG00000132646.10 PCNA 20 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Activation of E2F1 target genes at G1/S; Removal of the Flap Intermediate; PCNA-Dependent Long Patch Base Excision Repair; Transcription of E2F targets under negative control by DREAM complex; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; SUMOylation of DNA replication proteins; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; E3 ubiquitin ligases ubiquitinate target proteins; Dual incision in TC-NER; Removal of the Flap Intermediate from the C-strand Hepatitis B; DNA replication; Mismatch repair; Base excision repair; HTLV-I infection; Nucleotide excision repair; Cell cycle 0 High P68431 Histone H3.1 OS=Homo sapiens OX=9606 GN=HIST1H3A PE=1 SV=2 0 40.598 52 6 21 1 136 15.4 11.12 6 1 3 15 1 5 22392946.5 192043.6367 2 2 cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;membrane;nucleus catalytic activity;DNA binding;protein binding "Pf00125, Pf15630" 8968; 8352; 8351; 8355; 8357; 8358; 8350; 8353; 8354; 8356 ENSG00000197153.4; ENSG00000275379.1; ENSG00000278272.1; ENSG00000277775.1; ENSG00000273983.1; ENSG00000274750.2; ENSG00000274267.1; ENSG00000197409.7; ENSG00000275714.1; ENSG00000278828.1 HIST1H3F; HIST1H3C; HIST1H3D; HIST1H3G; HIST1H3H; HIST1H3B; HIST1H3A; HIST1H3E; HIST1H3I; HIST1H3J 6 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Interleukin-7 signaling; Factors involved in megakaryocyte development and platelet production; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Transcriptional misregulation in cancer; Systemic lupus erythematosus; Alcoholism 1 High Q659C4 La-related protein 1B OS=Homo sapiens OX=9606 GN=LARP1B PE=1 SV=2 0 55.114 17 12 21 6 914 105.3 7.61 12 1 20 1 85955.57813 12271873.13 19093.06055 1036571.625 1 4 1 1 Acetyl [N-Term] nucleus protein binding;RNA binding Pf05383 55132 ENSG00000138709.17 LARP1B 4 0 High Q9UK97 F-box only protein 9 OS=Homo sapiens OX=9606 GN=FBXO9 PE=1 SV=1 0 44.628 31 12 21 12 447 52.3 6.15 5 10 9 12 667203.5265 9267610.625 19943585.25 12838115.31 2 5 10 10 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;protein binding "Pf00646, Pf12937" 26268 ENSG00000112146.16 FBXO9 6 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q7L2J0 7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1 0 67.18 35 14 21 14 689 74.3 9.57 14 1 20 1 391461.9688 38887422.5 1552231.75 706933.0625 1 12 1 2 metabolic process;regulation of biological process catalytic activity;RNA binding "Pf00891, Pf05175, Pf06325, Pf06859, Pf08241, Pf08242, Pf12847, Pf13659, Pf13847" 56257 ENSG00000146834.13 MEPCE 7 0 High Q15024 Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3 0 94.712 49 10 20 10 291 31.8 5.19 10 1 1 18 1 1 159575173.8 1039762.125 1415652.02 10 2 4 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf01138, Pf03725" 23016 ENSG00000075914.12 EXOSC7 3 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High Q9BV38 WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2 0 56.666 34 12 20 12 432 47.4 6.7 12 20 6332178.094 153235085 8675224.922 3686636.938 3 12 2 2 development;metabolic process cytoplasm;nucleus protein binding "Pf00400, Pf14077" 57418 ENSG00000065268.10 WDR18 19 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q9BTY2 Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2 0 40.927 29 13 20 13 467 54 6.25 13 20 9293402.422 871746.1875 37251804.5 3 2 14 metabolic process;regulation of biological process;response to stimulus;transport extracellular;organelle lumen catalytic activity;protein binding Pf01120 2519 ENSG00000001036.13 FUCA2 6 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation Other glycan degradation 0 High Q6IQ23 Pleckstrin homology domain-containing family A member 7 OS=Homo sapiens OX=9606 GN=PLEKHA7 PE=1 SV=2 0 38.875 12 12 20 12 1121 127.1 9.35 5 10 5 15 348897.4063 211304211.1 17231645.44 15557093.78 1 5 9 11 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;protein binding "Pf00169, Pf00397, Pf01576, Pf01920, Pf02463, Pf03961, Pf07798, Pf14992, Pf15409, Pf15413" 144100 ENSG00000166689.15 PLEKHA7 11 0 High Q9Y5Q9 General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1 0 80.697 25 16 20 16 886 101.2 5.07 16 1 19 1 15910529.64 44206374.66 18198.40039 540562.1523 2 13 1 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process membrane;nucleus DNA binding;protein binding "Pf13414, Pf13424, Pf13432" 9330 ENSG00000119041.10 GTF3C3 2 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 High P56182 Ribosomal RNA processing protein 1 homolog A OS=Homo sapiens OX=9606 GN=RRP1 PE=1 SV=1 0 44.712 34 14 20 14 461 52.8 9.33 13 2 18 2 46849.73438 79512774.75 43522105.44 3193445.109 1 11 6 4 metabolic process nucleus RNA binding Pf05997 8568 ENSG00000160214.12 RRP1 21 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q9NQ55 Suppressor of SWI4 1 homolog OS=Homo sapiens OX=9606 GN=PPAN PE=2 SV=1 0 58.399 28 12 20 12 473 53.2 10.13 12 1 19 1 313259.0508 119336813.1 1084861 383923.5938 3 12 1 1 cell organization and biogenesis nucleus RNA binding Pf04427 56342; 692312 ENSG00000130810.19 PPAN; PPAN-P2RY11 19 0 High P35749 Myosin-11 OS=Homo sapiens OX=9606 GN=MYH11 PE=1 SV=3 0 35.929 6 12 20 2 1972 227.2 5.5 1 7 5 3 1 8 8 3 183023.375 2089501.125 1 1 cell organization and biogenesis;metabolic process;transport cytoskeleton;cytosol;extracellular catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00038, Pf00063, Pf01442, Pf01576, Pf02463, Pf02736, Pf04111, Pf04156, Pf05622, Pf06160, Pf07888, Pf09311, Pf09726, Pf09731, Pf10079, Pf12128, Pf12252, Pf12325, Pf13166" 4629 ENSG00000133392.17; ENSG00000276480.5 MYH11 16; CHR_HSCHR16_1_CTG1 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Vascular smooth muscle contraction 0 High Q8N9T8 Protein KRI1 homolog OS=Homo sapiens OX=9606 GN=KRI1 PE=1 SV=3 0 80.913 22 10 20 10 703 82.5 5.14 10 1 19 1 2097637.125 80498226.25 4090372.25 100521.125 2 10 3 1 metabolic process RNA binding "Pf05178, Pf12936" 65095 KRI1 19 0 High Q9Y4I1 Unconventional myosin-Va OS=Homo sapiens OX=9606 GN=MYO5A PE=1 SV=2 0 75.997 12 17 20 17 1855 215.3 8.48 15 2 18 2 2143150.531 30972629.06 2080193.352 913290.9668 3 14 4 5 Met-loss+Acetyl [N-Term] cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;vacuole catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;RNA binding "Pf00063, Pf00612, Pf00769, Pf01442, Pf01576, Pf01843, Pf02463, Pf04111, Pf04156, Pf05262, Pf05557, Pf06160, Pf07888, Pf07926, Pf09726, Pf09731, Pf10174, Pf12128, Pf12718, Pf13851, Pf14992, Pf15035, Pf15070" 4644 ENSG00000197535.14 MYO5A 15 Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation; Insulin processing 0 High Q9NZB2 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2 0 99.002 19 16 20 16 1118 121.8 8.88 16 20 968800.7656 75514987.5 4791384.125 6907354.453 3 16 4 5 Met-loss [N-Term] cytoplasm;cytosol;membrane;nucleus RNA binding 23196 ENSG00000048828.16 FAM120A 9 0 High Q9NRX1 RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1 0 60.837 49 10 20 10 252 27.9 9.73 10 20 227459.0195 82359880.75 340590.375 3 9 1 metabolic process cytosol;nucleus RNA binding Pf00013 56902 ENSG00000115946.7 PNO1 2 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q969N2 GPI transamidase component PIG-T OS=Homo sapiens OX=9606 GN=PIGT PE=1 SV=1 0 32.214 21 12 20 12 578 65.7 8.38 1 5 9 1 9 10 513651.702 7726062.234 23814094.69 29822666.5 3 4 8 11 cell death;cell differentiation;metabolic process cytoplasm;endoplasmic reticulum;membrane catalytic activity;protein binding Pf04113 51604 ENSG00000124155.17 PIGT 20 Attachment of GPI anchor to uPAR Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 High Q68D10 Protein SPT2 homolog OS=Homo sapiens OX=9606 GN=SPTY2D1 PE=1 SV=3 0 62.444 30 13 20 13 685 75.6 9.79 13 20 90327.39063 61003932.25 385077.9375 1 11 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf08243 144108 ENSG00000179119.14 SPTY2D1 11 0 High Q8IXB1 DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2 0 35.085 19 12 20 12 793 91 7.18 8 9 8 12 1741.120483 24204034.13 5397134.156 6577365.125 1 7 5 6 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;enzyme regulator activity;protein binding "Pf00085, Pf00226, Pf13098, Pf13728, Pf13848, Pf13905" 54431 ENSG00000077232.17 DNAJC10 2 Protein processing in endoplasmic reticulum 0 High Q9NWT1 p21-activated protein kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAK1IP1 PE=1 SV=2 0 65.644 43 12 20 12 392 43.9 8.91 12 2 18 2 1306046.5 74395334.31 485596.9688 105383.375 1 10 1 1 cell proliferation;regulation of biological process nucleus protein binding Pf00400 55003 ENSG00000111845.4 PAK1IP1 6 0 High P48047 "ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1" 0 38.705 46 8 20 8 213 23.3 9.96 4 3 3 4 7 3 4 6 3069515.875 14449921 15744139.56 12501584.19 4 4 6 6 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity Pf00213 539 ENSG00000241837.6 ATP5O 21 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High Q8NEZ5 F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1 0 49.856 32 11 20 11 403 44.5 7.03 7 9 11 9 1171143.109 5364349 27400111 14854017.06 2 3 10 10 Acetyl [N-Term] cell communication;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00646, Pf10442, Pf12937" 26263 ENSG00000167196.13 FBXO22 15 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q15084 Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1 0 49.567 27 10 20 10 440 48.1 5.08 1 1 10 1 2 17 556993.653 4195051.495 2394295.063 50685528.63 3 5 2 10 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 10130 ENSG00000143870.12 PDIA6 2 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum 0 High Q06265 Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3 0 50.18 27 10 20 10 439 48.9 5.29 10 1 1 17 2 1 1620978.234 177874386.8 3748135.248 1097283.332 2 10 5 4 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf01138, Pf03725" 5393 ENSG00000123737.12 EXOSC9 4 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High Q9H4L4 Sentrin-specific protease 3 OS=Homo sapiens OX=9606 GN=SENP3 PE=1 SV=2 0 71.556 31 12 20 12 574 65 8.56 12 20 832535.0508 52908229.88 2396384.336 1418888.984 3 10 3 4 metabolic process cytoplasm;nucleus catalytic activity;protein binding Pf02902 26168 ENSG00000161956.12 SENP3 17 Major pathway of rRNA processing in the nucleolus and cytosol 0 High P78316 Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3 0 71.487 19 15 20 15 857 97.6 7.58 15 20 507361.3164 50881472.13 162209.25 2421247.938 3 14 1 4 metabolic process membrane;mitochondrion;nucleus protein binding;RNA binding Pf04147 8602 ENSG00000087269.15 NOP14 4 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q6DKI1 60S ribosomal protein L7-like 1 OS=Homo sapiens OX=9606 GN=RPL7L1 PE=1 SV=2 0 45.479 38 10 19 10 255 29.7 10.52 10 1 18 1 85965.42969 107390120.5 490538.2813 236428.4375 1 9 1 1 0 High Q9Y285 Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3 0 78.416 29 11 19 11 508 57.5 7.8 7 3 6 9 3 7 23035452.5 6873874.703 8992325.359 8 6 8 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf01409, Pf08279, Pf12802, Pf13463" 2193 ENSG00000179115.10 FARSA 19 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q00341 Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=2 0 62.951 17 17 19 17 1268 141.4 6.87 17 19 625992.9688 63482076.94 372718.9375 4 15 1 Met-loss+Acetyl [N-Term] metabolic process;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00013, Pf13014, Pf14611" 3069 HDLBP 2 HDL clearance 0 High Q9NUL7 Probable ATP-dependent RNA helicase DDX28 OS=Homo sapiens OX=9606 GN=DDX28 PE=1 SV=2 0 54.264 24 12 19 12 540 59.5 10.42 12 19 75306.17188 80524715 20721642 27659914.68 1 12 1 3 cell organization and biogenesis;metabolic process cytosol;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271" 55794 ENSG00000182810.6 DDX28 16 0 High P31689 DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2 0 63.985 44 10 19 10 397 44.8 7.08 7 3 4 10 4 5 225828.1914 30384391.5 8387542.938 14702864.69 2 8 6 8 Met-loss [N-Term] cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 3301 ENSG00000086061.15 DNAJA1 9 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 High P32119 Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5 0 18.218 40 6 19 5 198 21.9 5.97 3 5 1 3 5 7 1 6 1521398.75 21711126.5 3829738.656 2784621.906 2 4 3 3 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 7001 ENSG00000167815.11 PRDX2 19 TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species 0 High Q9P0L2 Serine/threonine-protein kinase MARK1 OS=Homo sapiens OX=9606 GN=MARK1 PE=1 SV=2 0 36.478 15 11 19 2 795 88.9 9.36 11 1 18 1 3110501.875 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane catalytic activity;metal ion binding;nucleotide binding "Pf00069, Pf00627, Pf02149, Pf07714, Pf14531" 4139 ENSG00000116141.15 MARK1 1 0 High O43684 Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1 0 33.236 37 10 19 10 328 37.1 6.84 5 3 7 8 4 7 4963523.75 28766913.38 11691834.88 6719808.398 2 6 5 6 cell division;cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytosol;nucleus protein binding "Pf00400, Pf04762" 9184 ENSG00000154473.17 BUB3 10 Inactivation of APC/C via direct inhibition of the APC/C complex; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; APC-Cdc20 mediated degradation of Nek2A HTLV-I infection; Cell cycle 0 High Q9UKV8 Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3 0 57.711 23 15 19 11 859 97.1 9.19 1 10 8 1 10 8 3486527.953 26097537.88 3049483.781 7437874.062 3 9 5 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 27161 ENSG00000123908.11 AGO2; EIF2C2 8 Post-transcriptional silencing by small RNAs; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation 4 High O43324 Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1 0 54.31 57 9 19 9 174 19.8 8.54 9 1 1 17 1 1 36695572.72 237437317.7 5840022.813 13701900.41 2 9 3 4 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00043, Pf13410, Pf14497" 9521 ENSG00000124802.11 EEF1E1 6 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins 0 High O00566 U3 small nucleolar ribonucleoprotein protein MPP10 OS=Homo sapiens OX=9606 GN=MPHOSPH10 PE=1 SV=2 0 74.239 20 10 19 10 681 78.8 4.86 10 19 96069.28125 71437518.88 78193.71875 1 10 1 metabolic process;regulation of biological process chromosome;nucleus protein binding;RNA binding Pf04006 10199 ENSG00000124383.8 MPHOSPH10 2 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q15397 Pumilio homolog 3 OS=Homo sapiens OX=9606 GN=PUM3 PE=1 SV=3 0 107.193 28 14 19 14 648 73.5 9.64 14 19 2245402.469 73386842.25 3574532.289 4205544.429 2 13 5 6 regulation of biological process chromosome;endoplasmic reticulum;nucleus DNA binding;protein binding;RNA binding "Pf07369, Pf08144" 9933 ENSG00000080608.9 KIAA0020; PUM3 9 0 High Q9Y3A4 Ribosomal RNA-processing protein 7 homolog A OS=Homo sapiens OX=9606 GN=RRP7A PE=1 SV=2 0 84.985 46 11 19 11 280 32.3 9.58 11 19 1932101.641 113153394.3 5713887.012 6464815.426 3 11 3 2 cell organization and biogenesis;metabolic process cytoplasm protein binding;RNA binding "Pf00076, Pf12923" 27341 ENSG00000189306.10 RRP7A 22 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P51659 Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3 0 39.125 17 10 19 10 736 79.6 8.84 6 5 1 2 10 5 2 2 8503607.313 36357691.19 2561272.32 6101355.116 7 6 5 5 cell differentiation;metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding "Pf00106, Pf01575, Pf02036, Pf08659, Pf13452, Pf13561, Pf14864" 3295 ENSG00000133835.14 HSD17B4 5 Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids Peroxisome; Metabolic pathways; Primary bile acid biosynthesis 0 High Q9GZS1 DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3 0 55.683 31 13 19 13 419 47.2 8.94 12 2 17 2 2257488.563 86520176.38 1024518.75 89630.72656 3 12 1 1 Met-loss+Acetyl [N-Term] 0 High P84243 Histone H3.3 OS=Homo sapiens OX=9606 GN=H3F3A PE=1 SV=2 0 30.812 51 6 19 2 136 15.3 11.27 6 1 3 13 1 5 317948434.5 7004206.226 21284180.22 5 2 5 cell differentiation;cell organization and biogenesis;cell proliferation;coagulation;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;nucleus DNA binding;protein binding "Pf00125, Pf15630" 3020; 440926; 3021 ENSG00000132475.10; ENSG00000163041.9 H3F3A; H3F3AP4; H3F3B 1; 2; 17 SIRT1 negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening Transcriptional misregulation in cancer; Systemic lupus erythematosus; Alcoholism 4 High Q9Y6V7 Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1 0 79.49 35 12 19 12 483 54.2 9.06 12 19 2047840.563 79301361 345144.4844 238753.3423 2 11 2 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf03592, Pf13863" 54555 ENSG00000105671.11 DDX49 19 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q04637 Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4 0 62.533 14 16 19 14 1599 175.4 5.33 15 1 18 1 56611004.44 48433631.38 1240997.625 3256543.25 4 11 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus nucleotide binding;protein binding;RNA binding;structural molecule activity "Pf00566, Pf02020, Pf02847, Pf02854" 1981 ENSG00000114867.20 EIF4G1 3 ISG15 antiviral mechanism; mTORC1-mediated signalling; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation RNA transport; Viral myocarditis 2 High Q9NPD3 Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3 0 54.397 36 7 19 7 245 26.4 6.52 7 2 17 2 182839.9844 126970736.8 19044572.5 17630898.05 1 7 3 2 Met-loss+Acetyl [N-Term] defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf01138, Pf03725" 54512 ENSG00000178896.8 EXOSC4 8 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High P56537 Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1 0 64.91 43 6 19 6 245 26.6 4.68 6 3 1 15 3 1 87025270.63 1496861.469 287931.6875 5 3 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;RNA binding Pf01912 3692 ENSG00000242372.6 EIF6 20 Ribosome biogenesis in eukaryotes 0 High P38435 Vitamin K-dependent gamma-carboxylase OS=Homo sapiens OX=9606 GN=GGCX PE=1 SV=2 0 35.362 17 12 19 12 758 87.5 8.02 8 7 12 7 203151.9219 1525258.678 36420817.31 12391136 1 3 9 9 Met-loss+Acetyl [N-Term] coagulation;metabolic process endoplasmic reticulum;membrane catalytic activity Pf05090 2677 ENSG00000115486.11 GGCX 2 Gamma-carboxylation of protein precursors Ubiquinone and other terpenoid-quinone biosynthesis 0 High Q9NP64 Nucleolar protein of 40 kDa OS=Homo sapiens OX=9606 GN=ZCCHC17 PE=1 SV=1 0 36.14 27 6 19 6 241 27.6 9.7 4 5 1 2 5 9 2 3 1384699 48154308.88 1953543.25 4821883.328 3 5 1 3 nucleus metal ion binding;protein binding;RNA binding Pf00575 51538 ENSG00000121766.15 ZCCHC17 1 0 High Q10567 AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=2 0 61.498 17 14 19 3 949 104.6 5.06 14 1 18 1 504871424 4602448.563 148173.8262 1 3 2 regulation of biological process;transport cytosol;Golgi;membrane protein binding;transporter activity "Pf01602, Pf02883, Pf09066, Pf12717, Pf13646" 162 AP1B1 22 Nef mediated downregulation of MHC class I complex cell surface expression; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis Lysosome 0 High Q15287 RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1 0 19.734 23 5 19 5 305 34.2 11.84 1 3 4 5 2 3 7 7 2879135.906 191128363.1 25588860.44 15024448.72 3 4 6 6 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf11608, Pf13893, Pf14259" 10921 ENSG00000205937.11 RNPS1 16 mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High P82663 "28S ribosomal protein S25, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1" 0 58.529 61 10 19 10 173 20.1 8.82 10 1 18 1 1128309.453 108723575.4 1174626.781 20809063.98 3 10 2 4 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf05047 64432 ENSG00000131368.7 MRPS25 3 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High O15160 DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1 0 52.952 39 9 19 9 346 39.2 5.5 1 9 2 1 1 15 2 1 238400.6875 77822955.38 18703305.81 19041600.38 1 10 3 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf01000, Pf01193" 9533 ENSG00000171453.17 POLR1C 6 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase I Transcription Termination; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q9BU76 Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1 0 41.241 46 10 18 10 263 29.4 10.02 10 1 4 13 1 4 4532936.875 68613422.94 3936955.109 8004271.75 3 10 3 3 transport extracellular;organelle lumen protein binding;RNA binding Pf10159 79169 ENSG00000143793.12 C1orf35 1 Neutrophil degranulation 0 High O75683 Surfeit locus protein 6 OS=Homo sapiens OX=9606 GN=SURF6 PE=1 SV=3 0 63.731 35 12 18 12 361 41.4 10.64 12 1 16 2 126042.9141 134452626.3 23463595.69 14355088.31 1 10 3 3 nucleus DNA binding;protein binding;RNA binding Pf04935 6838 ENSG00000281309.1; ENSG00000148296.6 SURF6 9; CHR_HG2030_PATCH 0 High P19013 "Keratin, type II cytoskeletal 4 OS=Homo sapiens OX=9606 GN=KRT4 PE=1 SV=4" 0 9.357 7 4 18 1 534 57.3 6.61 3 3 3 2 6 4 5 3 451611.9063 1 cell death;cell differentiation;cell organization and biogenesis;regulation of biological process cell surface;cytoskeleton;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf10234, Pf13166" 3851 KRT4 12 Formation of the cornified envelope 0 High Q8WU90 Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1 0 62.829 27 11 18 11 426 48.6 5.31 11 18 144153.4219 51727045.88 3858264.375 14893261 1 11 2 1 regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus metal ion binding;protein binding;RNA binding Pf00642 55854 ENSG00000065548.17 ZC3H15 2 0 High P51532 Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2 0 35.903 7 11 18 11 1647 184.5 7.88 4 1 2 9 4 1 3 10 2296866.41 3959737.875 6269481.125 10458543.56 5 3 6 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619" 6597 ENSG00000127616.17 SMARCA4 19 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; Formation of the beta-catenin:TCF transactivating complex; Interleukin-7 signaling 0 High O43809 Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1 0 35.921 44 7 18 7 227 26.2 8.82 2 7 2 2 3 9 4 2 2290551.875 29698597.88 3530983.5 20714357.25 3 7 2 2 cell organization and biogenesis;metabolic process nucleus catalytic activity;protein binding;RNA binding Pf13869 11051 ENSG00000167005.13 NUDT21 16 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High Q9NQT4 Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1 0 50.148 37 6 18 6 235 25.2 7.59 6 2 16 2 144653927.8 10780692.62 8347475.75 6 4 3 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf01138, Pf03725" 56915 ENSG00000077348.8 EXOSC5 19 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High Q12986 Transcriptional repressor NF-X1 OS=Homo sapiens OX=9606 GN=NFX1 PE=1 SV=2 0 69.678 20 15 18 15 1120 124.3 8.24 15 18 31368874.5 1013508.75 1820752.969 11 1 3 defense response;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;RNA binding Pf01424 4799 ENSG00000086102.18 NFX1 9 0 High P31942 Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2 0 33.424 33 8 18 7 346 36.9 6.87 2 5 3 2 4 6 5 3 869253.0156 22375205.25 2402811.063 2883802.906 2 4 2 3 cell differentiation;metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf14259" 3189 ENSG00000096746.17 HNRNPH3 10 0 High Q2M1P5 Kinesin-like protein KIF7 OS=Homo sapiens OX=9606 GN=KIF7 PE=1 SV=2 0 33.389 13 12 18 11 1343 150.5 6.79 1 6 10 1 6 11 324004.4453 37322248 10465283.22 6375520.672 2 6 9 10 cellular component movement;metabolic process;regulation of biological process cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf04111" 374654 ENSG00000166813.14 KIF7 15 Hedgehog 'on' state; Hedgehog 'off' state Hedgehog signaling pathway 1 High P17812 CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2 0 50.168 30 11 18 11 591 66.6 6.46 6 3 7 7 4 7 716758.9063 13598989.5 8235663.094 7767681.063 2 5 6 8 cell proliferation;metabolic process;response to stimulus cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00117, Pf06418, Pf07722" 1503 ENSG00000171793.13 CTPS1 1 Interconversion of nucleotide di- and triphosphates Metabolic pathways; Pyrimidine metabolism 0 High Q8TF42 Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens OX=9606 GN=UBASH3B PE=1 SV=2 0 27.192 16 9 18 9 649 72.6 6.93 8 4 14 4 68229.67969 6729510.563 38786159.56 20125511.67 1 4 9 10 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;protein binding "Pf00018, Pf00300, Pf00627, Pf13563, Pf14604" 84959 ENSG00000154127.9 UBASH3B 11 0 High P48643 T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1 0 18.955 18 10 18 9 541 59.6 5.66 1 9 6 1 10 7 818365.9521 19957240.75 6628220.438 9760908.875 3 7 7 7 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 22948 ENSG00000150753.11 CCT5 5 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High Q8TED0 U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3 0 59.175 34 14 18 14 518 58.4 9.11 14 18 1741134.352 47063388.05 5 14 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;nucleus protein binding;RNA binding "Pf00400, Pf09384" 84135 ENSG00000164338.9 UTP15 5 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9Y265 RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1 0 52.782 38 12 18 12 456 50.2 6.42 1 9 1 6 1 9 2 6 5002370.672 25823953 4111129.496 7210332.529 4 9 6 8 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00004, Pf01078, Pf01695, Pf05496, Pf06068, Pf06414, Pf07726, Pf13191, Pf13238, Pf13245, Pf13481" 8607 ENSG00000175792.11 RUVBL1 3 Ub-specific processing proteases; UCH proteinases; DNA Damage Recognition in GG-NER; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; Deposition of new CENPA-containing nucleosomes at the centromere Wnt signaling pathway 0 High Q9Y4L1 Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1 0 34.087 11 11 18 11 999 111.3 5.22 4 10 5 13 224056.1406 7361142.406 10846867.14 15813851.2 1 5 11 11 regulation of biological process;response to stimulus;transport endoplasmic reticulum;extracellular;membrane;organelle lumen nucleotide binding;protein binding Pf00012 10525 ENSG00000280682.2; ENSG00000149428.18 HYOU1 11; CHR_HG2217_PATCH Scavenging by Class F Receptors; XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum 0 High Q8IWX8 Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3 0 55.095 17 11 18 11 916 103.6 9.04 1 10 2 1 15 2 1024957.531 76223500.13 1268094.906 1208937.391 2 10 3 4 cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;membrane protein binding;RNA binding "Pf01585, Pf01805, Pf04818" 10523 ENSG00000085872.14 CHERP 19 mRNA Splicing - Major Pathway Spliceosome 0 High Q8WWK9 Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1 0 63.271 27 11 18 11 683 76.9 9.41 11 18 587343.375 34927389.75 8031398 7411031 1 10 3 5 cell death;regulation of biological process cytoplasm;cytoskeleton;cytosol "Pf08542, Pf15297" 26586 ENSG00000136108.14 CKAP2 13 0 High P49916 DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2 0 27.508 11 10 18 10 1009 112.8 9.01 1 1 9 4 1 2 11 4 19263972.38 12506978.38 4148708.844 6 7 5 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00645, Pf01068, Pf04675, Pf04679" 3980 ENSG00000005156.11 LIG3 17 Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER Base excision repair 0 High Q9HCM4 Band 4.1-like protein 5 OS=Homo sapiens OX=9606 GN=EPB41L5 PE=1 SV=3 0 33.168 22 9 18 8 733 81.8 6.58 1 6 3 6 2 7 3 6 597027.625 8862852.469 3466633.672 3453487.063 1 5 5 5 Acetyl [N-Term] cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity "Pf00373, Pf08736, Pf09379, Pf09380" 57669 ENSG00000115109.13 EPB41L5 2 Neurexins and neuroligins 1 High P61964 WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1 0 41.931 33 8 18 8 334 36.6 8.27 7 4 4 9 5 4 1083682.086 25517015.38 6401992 9119979.797 2 7 4 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;protein binding "Pf00400, Pf08662, Pf11715" 11091 ENSG00000196363.9 WDR5 9 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation 0 High Q9Y399 "28S ribosomal protein S2, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" 0 36.076 35 11 17 11 296 33.2 9.26 1 11 1 1 15 1 407224.5156 88255341.81 1782824.438 930915.375 2 11 2 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf00318 51116 ENSG00000122140.10 MRPS2 9 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q96BK5 PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2 0 74.945 44 12 17 12 328 37 9.6 12 17 15919192.05 73956164.88 862415.6563 4 10 3 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus enzyme regulator activity;protein binding;RNA binding "Pf01585, Pf12656" 54984 ENSG00000254093.8 PINX1 8 0 High Q9NYF8 Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2 0 46.228 17 11 17 10 920 106.1 9.98 9 2 1 14 2 1 375454.5625 30722307.63 2368306.375 2021222 1 6 2 3 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding Pf15440 9774 ENSG00000029363.16 BCLAF1 6 0 High P27816 Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3 0 60.927 16 12 17 12 1152 120.9 5.43 12 17 69526475.81 1370388.844 936224.1875 11 2 4 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton protein binding;RNA binding;structural molecule activity Pf00418 4134 ENSG00000047849.21 MAP4 3 0 High Q96N67 Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4 0 27.205 9 14 17 14 2140 242.4 6.8 10 2 2 13 2 2 5304958.031 734382.7188 2299669.625 1664010.032 10 2 2 4 cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus protein binding "Pf06920, Pf11878, Pf14429" 85440 ENSG00000116641.17 DOCK7 1 MET activates RAP1 and RAC1; Factors involved in megakaryocyte development and platelet production 0 High Q16585 Beta-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCB PE=1 SV=1 0 48.145 30 9 17 9 318 34.8 8.62 9 17 1935169.125 5378619.375 2263001.75 20677408.56 1 3 5 9 Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;membrane Pf04790 6443 ENSG00000163069.12 SGCB 4 Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Viral myocarditis; Hypertrophic cardiomyopathy (HCM) 0 High Q9H1I8 Activating signal cointegrator 1 complex subunit 2 OS=Homo sapiens OX=9606 GN=ASCC2 PE=1 SV=3 0 68.991 22 11 17 11 757 86.3 5.16 11 17 4336968.938 49696504.88 1242126.643 668891.625 3 11 2 2 Met-loss [N-Term] metabolic process;regulation of biological process nucleus protein binding Pf02845 84164 ENSG00000100325.14 ASCC2 22 ALKBH3 mediated reversal of alkylation damage 0 High P06280 Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1 0 25.495 14 5 17 5 429 48.7 5.6 2 5 5 12 7495257.094 15076031.94 4 5 metabolic process;regulation of biological process;transport cytoplasm;extracellular;Golgi;organelle lumen;vacuole catalytic activity;protein binding Pf02065 2717 ENSG00000102393.9 GLA X Glycosphingolipid metabolism; Neutrophil degranulation Lysosome; Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis - globo and isoglobo series 0 High Q92643 GPI-anchor transamidase OS=Homo sapiens OX=9606 GN=PIGK PE=1 SV=2 0 33.917 31 9 17 9 395 45.2 6.16 2 9 2 15 1172812.625 6236865.313 2794854.281 17410951.63 1 3 3 9 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding Pf01650 10026 ENSG00000142892.14 PIGK 1 Attachment of GPI anchor to uPAR Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 High Q9Y2P8 RNA 3'-terminal phosphate cyclase-like protein OS=Homo sapiens OX=9606 GN=RCL1 PE=1 SV=3 0 53.835 38 10 17 10 373 40.8 9.26 10 17 1217118.906 73875453 754144.8047 161088.1367 3 10 2 2 Met-loss+Acetyl [N-Term] metabolic process nucleus catalytic activity "Pf01137, Pf05189" 10171 ENSG00000120158.11 RCL1 9 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P09001 "39S ribosomal protein L3, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" 0 57.531 53 11 17 11 348 38.6 9.48 11 17 3543717.805 49370276.78 14555.68396 4 11 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome catalytic activity;RNA binding;structural molecule activity Pf00297 11222 ENSG00000114686.8 MRPL3 3 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q16891 MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1 0 29.982 15 9 17 9 758 83.6 6.48 1 6 4 4 2 7 4 4 10755729.94 145460085 4930691.75 5054349.875 3 8 4 5 cell organization and biogenesis;cellular homeostasis membrane;mitochondrion protein binding;RNA binding Pf09731 10989 ENSG00000132305.20 IMMT 2 Cristae formation 0 High Q15020 Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1 0 60.31 17 12 17 12 963 109.9 5.57 12 17 856308.75 30487574.88 633282.6719 561929.1719 2 11 2 3 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 9733 ENSG00000075856.11 SART3 12 0 High Q16629 Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1 0 43.571 28 8 17 7 238 27.4 11.82 1 6 3 2 1 11 3 2 789496.4624 93261067.5 10245630.97 4268746.601 3 5 5 4 metabolic process;regulation of biological process;transport cytoplasm;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6432 ENSG00000115875.18 SRSF7 2 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 High Q96EY1 "DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2" 0 54.221 30 11 17 11 480 52.5 9.26 9 1 2 14 1 2 505917.5 23485067.69 1653022.938 2872430.563 1 6 3 3 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 9093 ENSG00000276726.4; ENSG00000103423.13 DNAJA3 16; CHR_HSCHR16_3_CTG1 Viral carcinogenesis 0 High Q9Y676 "28S ribosomal protein S18b, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1" 0 54.076 57 9 17 9 258 29.4 9.38 9 17 66055641.13 7341752 1494825.281 8 2 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;structural molecule activity Pf01084 28973 ENSG00000227420.8; ENSG00000229861.8; ENSG00000233813.8; ENSG00000223775.8; ENSG00000226111.8; ENSG00000204568.11; ENSG00000203624.10 MRPS18B 6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Viral carcinogenesis 0 High O60264 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1 0 55.615 17 16 17 16 1052 121.8 8.09 16 17 4503879.313 34554001.38 1855924.75 8568225.347 4 14 1 3 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf04851, Pf09110, Pf09111, Pf11496" 8467 ENSG00000153147.5 SMARCA5 4 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression; B-WICH complex positively regulates rRNA expression; Deposition of new CENPA-containing nucleosomes at the centromere 0 High Q8IUF8 Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1 0 68.482 35 11 17 11 465 52.8 6.7 11 17 394149.125 42255397.75 2378335.688 1662323.063 2 11 4 3 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;metal ion binding;protein binding Pf08007 84864 ENSG00000170854.17 MINA; RIOX2 3 HDMs demethylate histones 0 High Q14241 Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=2 0 54.423 18 12 17 12 798 89.9 9.57 11 1 16 1 3866143.146 63214944.88 1701078.813 157177.877 3 11 2 2 metabolic process;regulation of biological process nucleus DNA binding;protein binding "Pf06881, Pf08711" 6924 ENSG00000011007.12 TCEB3; ELOA 1 HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat 0 High P25205 DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3 0 28.002 13 9 17 9 808 90.9 5.77 3 7 5 3 7 7 4415679.203 14039518.66 5762633.094 6332823.5 2 6 8 7 metabolic process cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf01078, Pf07728, Pf14551" 4172 ENSG00000112118.18 MCM3 6 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High Q15370 Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1 0 22.874 44 4 17 4 118 13.1 4.88 1 4 2 4 1 7 3 6 2263026.023 36554070.38 11004760 17429745.66 2 4 3 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding Pf00240 6923 ENSG00000103363.14 TCEB2; ELOB 16 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma 0 High Q5SNT2 Transmembrane protein 201 OS=Homo sapiens OX=9606 GN=TMEM201 PE=1 SV=1 0 26.007 20 9 17 9 666 72.2 9.22 9 4 13 4 3659118 31344371.66 11359184.72 1 8 8 Acetyl [N-Term] cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton;membrane;nucleus protein binding "Pf09779, Pf10476" 199953 ENSG00000188807.12 TMEM201 1 0 High Q12888 TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2 0 33.962 10 12 17 12 1972 213.4 4.7 1 8 5 1 11 5 944057.6875 2473470.188 9884644.25 3410489.719 1 2 9 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding "Pf09038, Pf15057" 7158 ENSG00000067369.13 TP53BP1 15 G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ) NOD-like receptor signaling pathway 0 High O95758 Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2 0 14.444 10 5 16 1 552 59.7 9.04 1 5 1 2 1 12 1 2 cell differentiation;metabolic process;regulation of biological process nucleus RNA binding "Pf00076, Pf13893, Pf14259" 9991 ENSG00000119314.15 PTBP3 9 0 High Q96QK8 Small integral membrane protein 14 OS=Homo sapiens OX=9606 GN=SMIM14 PE=1 SV=1 0 16.505 51 3 16 3 99 10.7 5.29 2 3 3 13 18194597.53 69677050.81 5 5 Met-loss+Acetyl [N-Term] endoplasmic reticulum;membrane protein binding Pf11027 201895 ENSG00000163683.11 C4orf34; SMIM14 4 0 High Q15050 Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2 0 52.22 30 10 16 10 365 41.2 10.7 10 1 15 1 521432.4063 49857960.25 649773.2969 581679.2422 1 11 3 4 Acetyl [N-Term] cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;endoplasmic reticulum;nucleus protein binding;RNA binding Pf04939 23212 ENSG00000179041.3 RRS1 8 0 High P14618 Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4 0 35.395 24 10 16 10 531 57.9 7.84 1 7 3 2 1 8 5 2 284781.3438 38356090.88 10560338.9 3664459.477 1 9 5 4 cell death;cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00224, Pf02887" 5315 ENSG00000067225.17 PKM 15 Glycolysis; Neutrophil degranulation Viral carcinogenesis; Central carbon metabolism in cancer; Carbon metabolism; Purine metabolism; Pyruvate metabolism; Type II diabetes mellitus; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 High Q9BYJ9 YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1 0 73.393 32 11 16 8 559 60.8 8.79 11 16 35869142.25 389540.75 2233949.83 9 1 3 regulation of biological process cytoplasm protein binding;RNA binding Pf04146 54915 ENSG00000149658.17 YTHDF1 20 0 High P55072 Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4 0 31.327 19 12 16 12 806 89.3 5.26 2 10 3 2 11 3 718186 18088271.5 10152272.89 3322446.363 2 4 8 6 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf02359, Pf02933, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13191, Pf13207, Pf13401" 7415 ENSG00000165280.15 VCP 9 Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs; Ovarian tumor domain proteases; ABC-family proteins mediated transport; HSF1 activation; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; E3 ubiquitin ligases ubiquitinate target proteins; Neutrophil degranulation; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum; Legionellosis 0 High Q09161 Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1 0 48.363 16 10 16 10 790 91.8 6.43 10 1 15 1 3236449.281 27896133.53 1292512.828 863127.3438 3 9 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;mitochondrion;nucleus protein binding;RNA binding "Pf02854, Pf09088, Pf09090" 4686 ENSG00000136937.12 NCBP1 9 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; SLBP independent Processing of Histone Pre-mRNAs; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; snRNP Assembly; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; mRNA 3'-end processing; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mRNA Capping; Regulation of expression of SLITs and ROBOs; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Formation of the Early Elongation Complex Spliceosome; mRNA surveillance pathway; RNA transport 0 High P62318 Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1 0 43.386 54 5 16 5 126 13.9 10.32 1 4 2 2 2 9 2 3 1358735.75 191812363 24263801.11 3527179.874 1 5 4 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6634 ENSG00000100028.11 SNRPD3 22 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome; Systemic lupus erythematosus 0 High Q14258 E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2 0 59.671 25 13 16 13 630 70.9 8.09 13 16 1888529.844 47169838 2131448.234 3453795.048 2 13 4 6 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;metal ion binding;motor activity;protein binding;RNA binding "Pf00097, Pf00622, Pf01576, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf15227" 7706 ENSG00000121060.16 TRIM25 17 Termination of translesion DNA synthesis; ISG15 antiviral mechanism; Interferon gamma signaling; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated NF-kB activation; TRAF6 mediated IRF7 activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway NF-kappa B signaling pathway; RIG-I-like receptor signaling pathway; Influenza A 0 High Q9BRP8 Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1 0 48.563 60 8 16 8 204 22.6 9.45 8 16 9541.619141 42313065.5 1033760.016 1312624.938 1 8 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus protein binding;RNA binding Pf09282 84305 ENSG00000170473.16 WIBG; PYM1 12 mRNA surveillance pathway; RNA transport 0 High P0C2W1 F-box/SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FBXO45 PE=1 SV=1 0 29.918 40 9 16 9 286 30.6 7.83 5 7 7 9 387530.2813 6188913.5 26390013.5 27577169.75 1 1 6 8 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;development;metabolic process;response to stimulus membrane protein binding "Pf00622, Pf00646, Pf12937" 200933 ENSG00000174013.7 FBXO45 3 0 High Q8IZ69 tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens OX=9606 GN=TRMT2A PE=1 SV=2 0 76.754 22 11 16 11 625 68.7 7.94 11 16 386769 41975202.5 2856388.234 4702705.742 1 9 2 3 metabolic process catalytic activity;RNA binding "Pf00076, Pf01135, Pf01170, Pf01209, Pf02475, Pf03602, Pf05175, Pf05958, Pf06325, Pf08241, Pf09445, Pf12847, Pf13649, Pf13659, Pf13847, Pf13893, Pf14259" 27037 ENSG00000099899.14 TRMT2A 22 0 High Q9Y5Q8 General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2 0 46.806 31 13 16 13 519 59.5 6.9 12 1 15 1 4985832.781 57334332.88 647172.7813 687711.7656 2 12 2 3 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;metabolic process nucleus DNA binding;protein binding Pf09734 9328 ENSG00000148308.17 GTF3C5 9 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 High Q9BZH6 WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1 0 71.498 17 14 16 14 1224 136.6 6.92 14 16 632681.375 35087786.31 1955855.891 569460.9258 2 12 2 5 cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding 55717 ENSG00000120008.15 WDR11 10 0 High Q9H936 Mitochondrial glutamate carrier 1 OS=Homo sapiens OX=9606 GN=SLC25A22 PE=1 SV=1 0 28.02 28 7 16 7 323 34.4 9.29 2 4 6 2 4 10 7161518.281 3230668.844 12420479.5 3 4 5 transport membrane;mitochondrion transporter activity Pf00153 79751 ENSG00000177542.10 SLC25A22 11 Organic anion transporters 0 High P49756 RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3 0 30.483 13 8 16 8 843 100.1 6.32 4 4 3 5 6 5 3806864.5 7258283.516 5350173.531 3 5 6 metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf01480, Pf14259" 58517 ENSG00000119707.13 RBM25 14 Spliceosome 0 High Q9UL40 Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1 0 67.3 50 10 16 10 294 32.9 9.09 10 16 160268.5313 57703535.38 1958850.438 1582618.656 1 10 2 2 regulation of biological process;response to stimulus cytoplasm;nucleus metal ion binding;protein binding;RNA binding Pf12874 23567 ENSG00000113761.11 ZNF346 5 0 High P00738 Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 0 22.504 13 5 16 5 406 45.2 6.58 4 5 8 8 13454.91895 13535364.5 40351756 21761249.63 1 2 5 5 defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;organelle lumen antioxidant activity;catalytic activity;protein binding Pf00089 3240 ENSG00000257017.8 HP 16 Neutrophil degranulation; Scavenging of heme from plasma 0 High Q9NTK5 Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2 0 47.637 33 11 16 11 396 44.7 7.81 11 1 15 1 726099.0664 58044649.5 1992616.844 341564.7813 2 10 3 1 metabolic process;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf01926, Pf02421, Pf06071" 29789 ENSG00000138430.15 OLA1 2 Platelet degranulation 0 High Q92547 DNA topoisomerase 2-binding protein 1 OS=Homo sapiens OX=9606 GN=TOPBP1 PE=1 SV=3 0 52.419 11 14 16 14 1522 170.6 6.96 14 16 1287307.086 999123137.1 4307417.953 1963984.406 2 12 3 3 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;nucleus DNA binding;protein binding "Pf00533, Pf12738" 11073 ENSG00000163781.12 TOPBP1 3 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation Homologous recombination 0 High P82932 "28S ribosomal protein S6, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3" 0 42.389 73 9 16 9 125 14.2 9.26 9 16 337947.5313 67671658.06 16798642 24059053.52 1 9 1 4 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf01250 64968 ENSG00000243927.5 MRPS6 21 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9BZ72 Membrane-associated phosphatidylinositol transfer protein 2 OS=Homo sapiens OX=9606 GN=PITPNM2 PE=1 SV=1 0 32.963 12 14 16 13 1349 148.8 7.17 9 7 9 7 3199623 22990891.75 12552838.59 8289471.359 3 4 13 9 metabolic process;transport cytosol;membrane metal ion binding;transporter activity "Pf02121, Pf02862, Pf08235" 57605 ENSG00000090975.12 PITPNM2 12 Synthesis of PI 1 High Q96EK4 THAP domain-containing protein 11 OS=Homo sapiens OX=9606 GN=THAP11 PE=1 SV=2 0 33.662 28 8 16 8 314 34.4 8.98 8 1 15 1 170763.3594 61917290.75 833824.75 1 7 1 Met-loss [N-Term] metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;metal ion binding;protein binding Pf05485 57215 ENSG00000168286.2 THAP11 16 0 High P31040 "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" 0 38.519 21 10 16 10 664 72.6 7.39 4 1 4 6 5 1 4 6 2186566.656 2072416.238 4950206.781 5704374.836 4 2 4 6 metabolic process;transport membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00890, Pf02910" 6389 ENSG00000073578.16 SDHA 5 Respiratory electron transport; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q9HCD5 Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2 0 34.514 22 10 16 10 579 65.5 9.6 6 2 6 7 2 7 3954991.326 58001060.62 3172854.188 4756729.219 7 5 3 5 metabolic process;regulation of biological process cytoskeleton;nucleus protein binding;RNA binding 57727 ENSG00000124160.11 NCOA5 20 0 High O94813 Slit homolog 2 protein OS=Homo sapiens OX=9606 GN=SLIT2 PE=1 SV=1 0 62.43 12 13 16 13 1529 169.8 7.06 12 1 14 2 762706.7813 31959189.88 526243.375 1881524.688 2 8 1 2 cell death;cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus cell surface;cytoplasm;extracellular;membrane enzyme regulator activity;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00008, Pf00054, Pf01462, Pf02210, Pf12799, Pf13306, Pf13855, Pf14580" 9353 ENSG00000145147.19 SLIT2 4 Netrin-1 signaling; SLIT2:ROBO1 increases RHOA activity; Activation of RAC1; Regulation of expression of SLITs and ROBOs; Regulation of commissural axon pathfinding by SLIT and ROBO; Inactivation of CDC42 and RAC1; Role of ABL in ROBO-SLIT signaling Axon guidance 0 High Q1ED39 Lysine-rich nucleolar protein 1 OS=Homo sapiens OX=9606 GN=KNOP1 PE=1 SV=1 0 81.614 32 13 16 13 458 51.6 9.86 13 16 185117.0313 65986301.56 7691737.063 9351741.813 1 12 4 5 nucleus RNA binding Pf15477 400506 ENSG00000103550.13 C16orf88; KNOP1 16 0 High O15371 Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1 0 79.449 30 12 16 12 548 63.9 6.05 12 1 2 13 1 2 888630.5 67479512.38 3125606.185 1677614.09 1 11 6 6 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding Pf05091 8664 ENSG00000100353.17 EIF3D 22 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High Q9UK99 F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3 0 23.826 18 7 15 7 471 54.5 5 6 4 9 6 249380.1563 5228173 14258570.94 14422251.88 1 3 6 7 metabolic process;regulation of biological process cytosol;nucleus catalytic activity;protein binding "Pf00646, Pf04379, Pf06881, Pf09346, Pf12937" 26273 ENSG00000110429.13 FBXO3 11 0 High P62993 Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1 0 29.92 46 8 15 8 217 25.2 6.32 2 8 3 2 10 3 4365865.063 22471155.81 6504898.741 3 8 7 cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;Golgi;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00017, Pf00018, Pf07653, Pf14604" 2885 ENSG00000177885.13 GRB2 17 "PI3K Cascade; SHC-mediated cascade:FGFR4; Signaling by FGFR4 in disease; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; Signal regulatory protein family interactions; EGFR downregulation; SHC1 events in ERBB4 signaling; NCAM signaling for neurite out-growth; DAP12 signaling; PI-3K cascade:FGFR4; GRB2 events in EGFR signaling; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Signaling by cytosolic FGFR1 fusion mutants; MET activates PI3K/AKT signaling; Constitutive Signaling by EGFRvIII; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin receptor SHC signaling; MET receptor recycling; FRS-mediated FGFR3 signaling; SHC-mediated cascade:FGFR3; Negative regulation of MET activity; FRS-mediated FGFR2 signaling; CD28 dependent Vav1 pathway; Signalling to RAS; GPVI-mediated activation cascade; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; RET signaling; SHC-mediated cascade:FGFR1; GRB2 events in ERBB2 signaling; PI-3K cascade:FGFR1; PI3K events in ERBB2 signaling; Role of LAT2/NTAL/LAB on calcium mobilization; RAF/MAP kinase cascade; Tie2 Signaling; FCERI mediated Ca+2 mobilization; SHC1 events in ERBB2 signaling; SHC-related events triggered by IGF1R; Signaling by FGFR2 in disease; FCERI mediated MAPK activation; Signaling by FGFR3 fusions in cancer; G beta:gamma signalling through PI3Kgamma; MET activates RAP1 and RAC1; Downstream signal transduction; Signaling by FGFR3 point mutants in cancer; MET activates RAS signaling; MET activates PTPN11; Signal attenuation; SHC-mediated cascade:FGFR2; EGFR Transactivation by Gastrin; Constitutive Signaling by Aberrant PI3K in Cancer; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; SOS-mediated signalling; Interleukin-20 family signaling; Interleukin-15 signaling; Spry regulation of FGF signaling; Cargo recognition for clathrin-mediated endocytosis; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SHC1 events in EGFR signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; RHO GTPases Activate WASPs and WAVEs; Regulation of KIT signaling; GAB1 signalosome; InlB-mediated entry of Listeria monocytogenes into host cell" Viral carcinogenesis; T cell receptor signaling pathway; Dorso-ventral axis formation; Osteoclast differentiation; Hepatitis B; Insulin signaling pathway; FoxO signaling pathway; Prolactin signaling pathway; MicroRNAs in cancer; Phospholipase D signaling pathway; Chronic myeloid leukemia; Neurotrophin signaling pathway; B cell receptor signaling pathway; Acute myeloid leukemia; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Natural killer cell mediated cytotoxicity; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Glioma; Gap junction; Renal cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Focal adhesion; Jak-STAT signaling pathway; Proteoglycans in cancer; Choline metabolism in cancer; mTOR signaling pathway; Fc epsilon RI signaling pathway; Hepatitis C; Alcoholism; Ras signaling pathway; Endocrine resistance; GnRH signaling pathway; Chemokine signaling pathway; Signaling pathways regulating pluripotency of stem cells; Estrogen signaling pathway; PI3K-Akt signaling pathway 0 High Q9Y597 BTB/POZ domain-containing protein KCTD3 OS=Homo sapiens OX=9606 GN=KCTD3 PE=1 SV=2 0 22.373 13 10 15 10 815 88.9 7.03 10 15 10587374.94 2508331.375 6406.276367 9 3 1 cell organization and biogenesis membrane protein binding Pf02214 51133 ENSG00000136636.12 KCTD3 1 0 High P62995 Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1 0 22.741 23 7 15 5 288 33.6 11.25 1 7 1 2 2 10 1 2 426175.0234 38374128.25 1415949.25 2979760.313 1 6 1 2 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 6434 ENSG00000136527.17 TRA2B 3 mRNA Splicing - Major Pathway Spliceosome 1 High P52434 "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" 0 48.651 59 9 15 9 150 17.1 4.68 9 1 14 1 37673868.47 2303107.063 2826896.781 9 4 4 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding Pf03870 5437 ENSG00000163882.9 POLR2H 3 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High P49674 Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1 0 44.214 23 9 15 3 416 47.3 9.66 9 1 14 1 227435.6719 58315713.25 3460236.125 2170703.938 1 9 4 4 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf01636, Pf07714" 1454; 102800317 ENSG00000213923.11; ENSG00000283900.1 CSNK1E; LOC400927-CSNK1E 22 WNT mediated activation of DVL; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Circadian Clock FoxO signaling pathway; Hippo signaling pathway; Wnt signaling pathway; Hippo signaling pathway -multiple species; Hedgehog signaling pathway; Circadian rhythm 6 High P01031 Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4 0 18.945 4 7 15 7 1676 188.2 6.52 5 6 7 8 1397.743652 41591201.06 16305045.5 11451484.22 1 3 6 7 cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf11974" 727 ENSG00000106804.7 C5 9 Terminal pathway of complement; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; G alpha (i) signalling events Prion diseases; Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Herpes simplex infection; Staphylococcus aureus infection 0 High Q9Y2X9 Zinc finger protein 281 OS=Homo sapiens OX=9606 GN=ZNF281 PE=1 SV=1 0 73.249 23 11 15 11 895 96.9 8.48 11 15 316632.8389 85232992.25 21346993.88 21250052.54 2 9 2 2 cell differentiation;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf13465" 23528 ENSG00000162702.7 ZNF281 1 0 High Q13242 Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1 0 34.31 46 10 15 9 221 25.5 8.65 10 15 205378.7969 111679213.3 966124.3438 457507.0625 1 9 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 8683 ENSG00000111786.8 SRSF9 12 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 0 High O15235 "28S ribosomal protein S12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" 0 52.99 53 8 15 8 138 15.2 10.29 8 1 14 1 105579084.8 1641781.969 1328440.195 8 2 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00164 6183 ENSG00000283018.1; ENSG00000128626.11 MRPS12 19; CHR_HG26_PATCH Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9BW19 Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2 0 59.951 24 12 15 12 673 73.7 8.98 12 15 527494.1094 26091478.25 21703370.88 23409222.47 2 10 3 2 cell division;cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton;endosome;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding Pf00225 3833 ENSG00000237649.7; ENSG00000204197.9; ENSG00000233450.7 KIFC1 6; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins 0 High P45880 Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2 0 21.093 24 6 15 6 294 31.5 7.56 2 4 5 2 7 6 2453812.188 4217502.625 13954642.88 9107353.25 2 2 5 5 regulation of biological process;transport membrane;mitochondrion;nucleus nucleotide binding;protein binding;transporter activity Pf01459 7417 ENSG00000165637.13 VDAC2 10 Mitochondrial calcium ion transport; Ub-specific processing proteases NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High Q9Y230 RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3 0 26.39 24 11 15 11 463 51.1 5.64 5 3 3 3 6 3 3 3 2560684.375 22911043.94 6536838.5 5557649.938 5 7 5 8 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03796, Pf06068, Pf13481" 10856 ENSG00000183207.13 RUVBL2 19 HATs acetylate histones; Telomere Extension By Telomerase 0 High P23526 Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4 0 22.749 20 8 15 8 432 47.7 6.34 4 3 7 5 3 7 3470856.625 3716441.428 5910307.906 8897705.375 4 3 4 6 Met-loss+Acetyl [N-Term] defense response;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00670, Pf02254, Pf02826, Pf05221" 191 ENSG00000101444.12 AHCY 20 "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD); Sulfur amino acid metabolism; Methylation" Metabolic pathways; Cysteine and methionine metabolism 0 High Q16698 "2,4-dienoyl-CoA reductase, mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" 0 49.113 36 9 15 9 335 36 9.28 8 2 13 2 89040.91406 32294320.75 3040204.563 1419220.438 1 5 3 2 cell organization and biogenesis;metabolic process cytosol;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding "Pf00106, Pf08659, Pf13561" 1666 ENSG00000104325.6 DECR1 8 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 0 High Q9Y295 Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1 0 62.811 35 11 15 11 367 40.5 8.9 11 15 673801.7969 59627380.63 14298007.66 11256157.21 2 10 3 2 development;metabolic process cytoplasm;cytosol;membrane nucleotide binding;protein binding "Pf00009, Pf01926, Pf02421, Pf02824" 4733 ENSG00000185721.12 DRG1 22 0 High Q9NX24 H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1 0 53.665 42 7 15 7 153 17.2 8.22 7 15 54826494.25 7 cell organization and biogenesis;metabolic process nucleus protein binding;RNA binding Pf01248 55651 ENSG00000145912.8 NHP2 5 rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase Ribosome biogenesis in eukaryotes 0 High P55084 "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" 0 33.632 24 9 15 9 474 51.3 9.41 1 5 6 1 1 5 8 1 398239.8125 36983037.25 7662569.438 2896438.313 1 7 7 5 metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;protein binding;RNA binding "Pf00108, Pf00109, Pf02803" 3032 ENSG00000138029.13 HADHB 2 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Fatty acid degradation; Fatty acid elongation; Metabolic pathways; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 High Q14146 Unhealthy ribosome biogenesis protein 2 homolog OS=Homo sapiens OX=9606 GN=URB2 PE=1 SV=2 0 62.484 11 13 15 13 1524 170.4 7.31 13 15 626652.8281 36473814.53 302991.5313 573898.4805 2 11 1 2 nucleus Pf10441 9816 ENSG00000135763.9 URB2 1 0 High O15460 Prolyl 4-hydroxylase subunit alpha-2 OS=Homo sapiens OX=9606 GN=P4HA2 PE=1 SV=1 0 35.928 26 12 15 12 535 60.9 5.71 3 11 3 12 226179.8516 8203485.125 17774455.06 12885328.84 2 4 8 12 metabolic process cytosol;endoplasmic reticulum;organelle lumen catalytic activity;metal ion binding;protein binding "Pf03171, Pf08336, Pf13640" 8974 ENSG00000072682.18 P4HA2 5 Collagen biosynthesis and modifying enzymes Metabolic pathways; Arginine and proline metabolism 0 High Q8TAQ2 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1 0 22.856 5 5 15 1 1214 132.8 5.69 3 2 3 4 3 2 4 6 461710.0625 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf04433 6601 ENSG00000139613.11 SMARCC2 12 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High P53621 Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2 0 41.086 11 10 15 10 1224 138.3 7.66 7 4 2 7 6 2 2179799.375 25536499.63 3315273.469 4678506.78 2 7 4 5 regulation of biological process;transport cytoplasm;cytosol;extracellular;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053, Pf06957" 1314 ENSG00000122218.14 COPA 1 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport 0 High Q96QR8 Transcriptional activator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3 0 21.42 23 9 15 7 312 33.2 5.43 9 1 14 1 323668.0938 71799324.25 1332059.563 106243.2188 1 9 3 1 cell differentiation;cell proliferation;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding Pf04845 5814 ENSG00000146676.8 PURB 7 2 High Q04837 "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" 0 14.765 27 4 15 4 148 17.2 9.6 2 4 3 2 7 6 273994.1563 5876747.875 28589920.75 14167786 1 2 4 4 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen DNA binding;protein binding;RNA binding Pf00436 6742 ENSG00000106028.10 SSBP1 7 Transcriptional activation of mitochondrial biogenesis Homologous recombination; DNA replication; Mismatch repair 0 High Q8WVV9 Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1 0 49.53 26 9 15 8 542 60 7.72 1 9 1 2 12 1 2401529.5 25478609.5 630436.75 965942.178 1 7 2 3 metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 92906 ENSG00000143889.15 HNRNPLL; HNRPLL 2 0 High Q8TCT9 Minor histocompatibility antigen H13 OS=Homo sapiens OX=9606 GN=HM13 PE=1 SV=1 0 22.243 14 4 15 4 377 41.5 6.43 4 3 11 4 1245534.406 66659331.75 4996160.656 3 4 4 cell organization and biogenesis;metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity;protein binding "Pf04258, Pf06550" 81502 ENSG00000101294.16 HM13 20 0 High P62891 60S ribosomal protein L39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2 0 10.331 24 2 15 2 51 6.4 12.56 2 1 1 12 2 1 637687205 9636574 3863800.75 2 1 1 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;ribosome RNA binding;structural molecule activity Pf00832 6170; 285785 ENSG00000198918.7 RPL39; RPL39P3 X; 6 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9BYN8 "28S ribosomal protein S26, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" 0 46.959 42 9 15 9 205 24.2 10.39 9 15 2460382.875 86203188.63 1171131.852 681874.748 2 9 3 2 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;ribosome RNA binding Pf14943 64949 ENSG00000125901.5 MRPS26 20 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q92665 "28S ribosomal protein S31, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" 0 56.667 32 10 15 10 395 45.3 9.29 10 1 14 1 494200.1875 48043235.88 705670.4375 429793.1836 2 7 1 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf15433 10240 ENSG00000102738.7 MRPS31 13 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q9UN81 LINE-1 retrotransposable element ORF1 protein OS=Homo sapiens OX=9606 GN=L1RE1 PE=1 SV=1 0 37.098 32 8 15 8 338 40 9.51 8 15 1117593.094 46149794.09 417496 700235.9116 2 7 1 2 cytoplasm;endoplasmic reticulum;nucleus;vacuole DNA binding;nucleotide binding;protein binding;RNA binding Pf02994 4029 LOC440264; L1RE1 22 0 High P98179 RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1 0 47.664 57 6 15 6 157 17.2 8.91 6 15 3339880.125 176075866.5 1275436.926 616472.5313 4 7 2 3 metabolic process;regulation of biological process cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 5935 ENSG00000102317.17 RBM3 X 0 High P54274 Telomeric repeat-binding factor 1 OS=Homo sapiens OX=9606 GN=TERF1 PE=1 SV=3 0 23.327 22 7 15 7 439 50.2 6.37 5 2 3 7 4 4 2173476.75 9992514.75 5162654.063 5403446.063 1 5 4 5 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;nucleus catalytic activity;DNA binding;protein binding "Pf00249, Pf08558" 7013 ENSG00000147601.13 TERF1 8 Meiotic synapsis; DNA Damage/Telomere Stress Induced Senescence; Packaging Of Telomere Ends 0 High Q9NZ01 Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1 0 27.178 24 9 15 9 308 36 9.45 3 3 7 3 3 9 246015.5938 17208016.87 7649879 19774067.88 1 5 5 8 metabolic process cytoplasm;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding Pf02544 9524 ENSG00000099797.13 TECR 19 Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism 0 High Q7Z406 Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2 0 17.507 4 8 15 3 1995 227.7 5.6 1 5 5 2 1 7 5 2 198422.75 43903747 3610564.75 1 2 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf01576" 79784 ENSG00000105357.15 MYH14 19 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Salmonella infection; Regulation of actin cytoskeleton 0 High Q9NY12 H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1 0 32.133 36 7 15 7 217 22.3 10.92 7 1 13 2 1874836.016 141492229.5 1680075.82 640126.5391 4 7 2 2 cell organization and biogenesis;metabolic process nucleus protein binding;RNA binding Pf04410 54433 ENSG00000109534.16 GAR1 4 rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High O75607 Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3 0 58.933 61 6 15 6 178 19.3 4.63 6 1 2 12 1 2 4636077.977 142023242.8 5320029.25 2844480.758 3 6 2 4 Met-loss+Acetyl [N-Term] metabolic process cytoskeleton;cytosol;nucleus protein binding;RNA binding "Pf02087, Pf03066" 10360 ENSG00000107833.10 NPM3 10 0 High P38432 Coilin OS=Homo sapiens OX=9606 GN=COIL PE=1 SV=1 0 29.944 16 9 14 9 576 62.6 9.07 9 2 12 2 150478.6563 39252572.63 1385402.781 2648475.891 1 9 2 2 membrane;nucleus protein binding 8161 ENSG00000121058.4 COIL 17 0 High P11586 "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=3" 0 17.34 8 6 14 6 935 101.5 7.3 1 3 3 4 1 3 5 5 1635716.031 37509517.25 6836938.188 5871181.188 1 3 5 5 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00763, Pf01268, Pf02882" 4522 MTHFD1 14 Metabolism of folate and pterines One carbon pool by folate; Metabolic pathways 0 High Q9BX40 Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1 0 62.069 33 9 14 9 385 42 9.69 9 14 2981367.922 23962220 1496989.797 1609373.375 3 6 3 3 development;regulation of biological process RNA binding "Pf09532, Pf12701, Pf14438" 149986 ENSG00000149657.19 LSM14B 20 0 High P48729 Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2 0 39.013 33 9 14 9 337 38.9 9.57 1 8 1 13 1422204.584 41276416 1972405.125 1561067.063 2 8 1 3 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1452 ENSG00000113712.17 CSNK1A1 5 S37 mutants of beta-catenin aren't phosphorylated; Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; APC truncation mutants have impaired AXIN binding; S45 mutants of beta-catenin aren't phosphorylated; GLI3 is processed to GLI3R by the proteasome; Misspliced GSK3beta mutants stabilize beta-catenin; Activation of SMO; Degradation of GLI2 by the proteasome; T41 mutants of beta-catenin aren't phosphorylated; Truncations of AMER1 destabilize the destruction complex Breast cancer; Wnt signaling pathway; Hedgehog signaling pathway 0 High P35613 Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2 0 33.331 22 7 14 7 385 42.2 5.66 1 5 4 1 6 7 175142.2031 11086333.5 20472522.88 9909792.375 1 5 6 4 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity "Pf00047, Pf07679, Pf13895, Pf13927" 682 ENSG00000172270.18 BSG 19 Integrin cell surface interactions; Proton-coupled monocarboxylate transport; Basigin interactions; Degradation of the extracellular matrix; Pyruvate metabolism 0 High Q9H7E2 Tudor domain-containing protein 3 OS=Homo sapiens OX=9606 GN=TDRD3 PE=1 SV=1 0 49.958 22 10 14 10 651 73.1 9.23 10 14 738107.6875 33554114.25 96757660.75 5253314.391 2 10 4 4 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding;RNA binding "Pf00567, Pf00627, Pf06003" 81550 ENSG00000083544.13 TDRD3 13 0 High Q9Y2W1 Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2 0 51.221 15 12 14 11 955 108.6 10.15 11 1 13 1 575804.2969 22698134 1166956.563 733700.5781 2 9 2 2 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;nucleotide binding;protein binding;receptor activity;RNA binding Pf15440 9967 ENSG00000054118.13 THRAP3 1 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 1 High Q8TCJ2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens OX=9606 GN=STT3B PE=1 SV=1 0 23.135 9 8 14 6 826 93.6 8.91 1 8 1 13 113409.2188 18808342.88 1307217.656 15933282.38 1 7 3 8 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding "Pf02516, Pf13231" 201595 ENSG00000163527.9 STT3B 3 N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 2 High Q9GZL7 Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2 0 43.689 26 8 14 8 423 47.7 5.9 8 1 13 1 48721819.88 1737336.906 1644547.844 8 3 3 cell proliferation;metabolic process;regulation of biological process;response to stimulus nucleus protein binding "Pf00400, Pf08154" 55759 ENSG00000138442.9 WDR12 2 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q13573 SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1 0 34.402 21 10 14 10 536 61.5 9.52 2 9 1 2 2 9 1 2 1202695.438 28304646.88 2175846.844 1324630.516 3 8 3 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex catalytic activity;protein binding;RNA binding Pf02731 22938 ENSG00000100603.13 SNW1 14 NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; mRNA Splicing - Major Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates NOTCH signaling; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation Viral carcinogenesis; Epstein-Barr virus infection; Spliceosome; Notch signaling pathway 0 High Q9UBS4 DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1 0 43.663 27 7 14 7 358 40.5 6.18 6 1 3 9 1 4 808053.0469 20760166.69 1294445.141 5700544.942 3 6 3 6 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;nucleus;organelle lumen protein binding "Pf00226, Pf01556" 51726 ENSG00000090520.11 DNAJB11 3 XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum 0 High Q07021 "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" 0 39.307 32 5 14 5 282 31.3 4.84 2 4 3 3 6 5 14438149.5 40281533.63 10366561.97 8961568.896 2 2 3 3 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen protein binding;RNA binding Pf02330 708 ENSG00000108561.8 C1QBP 17 Intrinsic Pathway of Fibrin Clot Formation Herpes simplex infection 0 High O95478 Ribosome biogenesis protein NSA2 homolog OS=Homo sapiens OX=9606 GN=NSA2 PE=1 SV=1 0 30.911 30 8 14 8 260 30 10.27 8 14 68976037.75 2500348 1619587.313 7 1 2 Met-loss [N-Term] metabolic process nucleus RNA binding Pf01201 10412 ENSG00000164346.9 NSA2 5 0 High Q13625 Apoptosis-stimulating of p53 protein 2 OS=Homo sapiens OX=9606 GN=TP53BP2 PE=1 SV=2 0 29.567 11 9 14 8 1128 125.5 6.07 4 7 5 9 1273817.899 6085793.313 7132653.094 3 7 9 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;mitochondrion;nucleus protein binding "Pf00018, Pf00023, Pf04111, Pf04156, Pf06785, Pf07653, Pf12252, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604, Pf15548" 7159 TP53BP2 1 Regulation of TP53 Activity through Association with Co-factors; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation of PUMA and translocation to mitochondria Hippo signaling pathway 1 High Q8NCJ5 SPRY domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SPRYD3 PE=1 SV=2 0 28.176 29 8 14 8 442 49.7 6.16 5 6 7 7 655576.4385 3887508.375 9962898.5 13234057.25 3 2 7 7 protein binding Pf00622 84926 ENSG00000167778.8 SPRYD3 12 0 High Q8N1N4 "Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2" 0 15.366 12 5 14 4 520 56.8 6.02 2 1 3 2 6 1 4 3 3318049.438 649957.3125 2 2 cell death cytosol structural molecule activity "Pf00038, Pf12128, Pf13166" 196374 ENSG00000170423.12 KRT78 12 Formation of the cornified envelope 0 High O43670 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 0 23.5 10 4 14 4 478 50.7 9.1 4 2 1 8 5 1 417118.8906 65779030.25 4148481.719 3390680.234 2 4 2 2 cell division;cell organization and biogenesis;regulation of biological process chromosome;cytoplasm;cytoskeleton;nucleus DNA binding;metal ion binding;protein binding;RNA binding 7756 ENSG00000010244.18 ZNF207 17 0 High Q93074 Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4 0 37.28 7 10 14 10 2177 242.9 7.05 1 2 10 1 2 11 1854.642456 9251147.867 1835033.625 4847991.938 1 4 4 8 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;protein binding;receptor activity "Pf09497, Pf12144, Pf12145" 9968 ENSG00000184634.15 MED12 X Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High Q99623 Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2 0 25.172 25 7 14 7 299 33.3 9.83 2 1 4 6 2 1 4 7 652121.9375 7933581.875 7098987.938 5998035.797 2 4 6 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;membrane;mitochondrion;nucleus protein binding Pf01145 11331 ENSG00000215021.8 PHB2 12 Processing of SMDT1 0 High Q9NZM5 Ribosome biogenesis protein NOP53 OS=Homo sapiens OX=9606 GN=NOP53 PE=1 SV=2 0 60.912 25 8 14 8 478 54.4 10.32 8 14 423775.3281 68248390.75 36493546.5 94701168.81 2 9 3 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus protein binding;RNA binding Pf07767 29997 ENSG00000105373.18 GLTSCR2; NOP53 19 Herpes simplex infection 0 High Q93063 Exostosin-2 OS=Homo sapiens OX=9606 GN=EXT2 PE=1 SV=1 0 40.77 16 11 14 11 718 82.2 6.55 11 14 242809.9063 96470686 4053199.203 19227728.38 1 4 2 10 cell differentiation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;protein binding "Pf03016, Pf09258" 2132 ENSG00000151348.13 EXT2 11 HS-GAG biosynthesis; Defective EXT2 causes exostoses 2 Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways 0 High P62633 Cellular nucleic acid-binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1 0 35.113 51 8 14 8 177 19.5 7.71 8 1 1 12 1 1 63786505 440586.7813 8 1 metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;nucleus DNA binding;metal ion binding;protein binding;RNA binding Pf00098 7555 ENSG00000169714.16 CNBP 3 0 High P21333 Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4 0 37.217 7 12 14 11 2647 280.6 6.06 8 4 10 4 7186201.5 10388387 5212516.426 4 10 10 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus protein binding;RNA binding;signal transducer activity "Pf00307, Pf00630" 2316 ENSG00000196924.14 FLNA X Platelet degranulation ; RHO GTPases activate PAKs; Cell-extracellular matrix interactions; GP1b-IX-V activation signalling MAPK signaling pathway; Focal adhesion; Proteoglycans in cancer; Salmonella infection 1 High O60870 DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2 0 40.049 34 11 14 11 393 45.3 8.95 11 14 31966160.5 2643780.969 2997437 11 3 3 metabolic process;response to stimulus cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf10357, Pf12874" 22944 ENSG00000151657.11 KIN 10 Protein methylation 0 High Q96GM8 Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1 0 59.478 33 11 14 11 510 56.5 7.18 11 14 380878.4063 39293862.13 5858637.469 1610661.326 2 9 2 4 metabolic process cytoplasm;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00642, Pf04857" 114034 ENSG00000132773.11 TOE1 1 0 High Q9Y5M8 Signal recognition particle receptor subunit beta OS=Homo sapiens OX=9606 GN=SRPRB PE=1 SV=3 0 26.637 32 7 14 7 271 29.7 9.04 2 2 7 3 2 9 7235892.125 3855424.75 10334185.03 4 3 7 regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane nucleotide binding "Pf00009, Pf00025, Pf01926, Pf02421, Pf09439" 58477 ENSG00000144867.11 SRPRB 3 XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export 0 High Q5VYS8 Terminal uridylyltransferase 7 OS=Homo sapiens OX=9606 GN=TUT7 PE=1 SV=1 0 61.6 11 13 14 13 1495 171.1 6.83 13 14 6088791.156 72013186 4654933.594 3975196.563 4 13 4 3 metabolic process cytoplasm;cytosol catalytic activity;metal ion binding;RNA binding "Pf00098, Pf01909, Pf03828" 79670 ENSG00000083223.17 ZCCHC6 9 Deadenylation of mRNA 0 High O76011 "Keratin, type I cuticular Ha4 OS=Homo sapiens OX=9606 GN=KRT34 PE=1 SV=2" 0 44.588 27 8 14 1 436 49.4 5.06 8 14 cell death;metabolic process cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf04156, Pf07888, Pf12128, Pf13514" 3885; 100653049 ENSG00000131737.5 KRT34; LOC100653049 17 Formation of the cornified envelope 0 High Q9Y2R5 "28S ribosomal protein S17, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" 0 46.35 52 4 14 4 130 14.5 9.85 4 1 2 10 1 3 330559.9063 79946185.5 1799646.617 591017.3652 1 5 2 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00366 51373 ENSG00000239789.5 MRPS17 7 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q01130 Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4 0 35.406 34 7 14 7 221 25.5 11.85 1 6 1 2 11 1 1295572.345 121506067.3 6320280.203 7648719.998 3 6 3 4 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6427 ENSG00000161547.16 SRSF2 17 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 High P08236 Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2 0 17.603 8 6 14 6 651 74.7 7.02 3 6 3 11 112618.1172 10779462.56 5208996.188 14434964.38 1 3 3 6 metabolic process;transport extracellular;membrane;organelle lumen;vacuole catalytic activity;protein binding "Pf02836, Pf02837, Pf12876" 2990 ENSG00000169919.16 GUSB 7 MPS VII - Sly syndrome; Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation Lysosome; Glycosaminoglycan degradation; Porphyrin and chlorophyll metabolism; Pentose and glucuronate interconversions; Metabolic pathways; Drug metabolism - other enzymes 0 High Q8IWF2 FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FOXRED2 PE=1 SV=1 0 39.145 20 12 14 12 684 77.7 7.72 2 11 2 12 572181.645 25682426.38 5806100.188 25146845.06 2 4 8 11 metabolic process endoplasmic reticulum;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf01266, Pf01946, Pf03486, Pf07992, Pf13450, Pf13738" 80020 ENSG00000100350.14 FOXRED2 22 0 High P16615 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2A2 PE=1 SV=1 0 32.813 11 11 14 11 1042 114.7 5.34 2 1 9 2 1 11 803.6800537 4445622.563 3946365.156 10797191.84 1 3 4 9 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 488 ENSG00000174437.16 ATP2A2 12 Ion homeostasis; Pre-NOTCH Processing in Golgi; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; cGMP-PKG signaling pathway; Thyroid hormone signaling pathway; Adrenergic signaling in cardiomyocytes; Pancreatic secretion; Alzheimer's disease; Cardiac muscle contraction; cAMP signaling pathway; Calcium signaling pathway; Hypertrophic cardiomyopathy (HCM) 0 High Q99547 M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2 0 56.069 38 7 14 7 160 19 5.2 7 14 2121577.094 90751124.63 21881.22827 2 9 1 metabolic process cytoplasm;nucleus protein binding;RNA binding Pf10175 10200 ENSG00000135698.9 MPHOSPH6 16 Major pathway of rRNA processing in the nucleolus and cytosol RNA degradation 0 High O43167 Zinc finger and BTB domain-containing protein 24 OS=Homo sapiens OX=9606 GN=ZBTB24 PE=1 SV=2 0 39.97 16 8 14 8 697 78.2 7.61 6 1 4 8 2 4 13830507.38 4228979.938 3050905.313 5 4 4 cell differentiation;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465" 9841 ENSG00000112365.4 ZBTB24 6 0 High Q15058 Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1 0 63.018 9 13 14 13 1648 186.4 7.91 13 14 32030057.88 571879.1875 11 1 cell division;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf00498, Pf00769, Pf01576, Pf02463, Pf02841, Pf05262, Pf05622, Pf09726, Pf09731, Pf11068, Pf11740, Pf12128, Pf13514, Pf13868" 9928 ENSG00000118193.11 KIF14 1 RHO GTPases activate CIT 0 High Q8NBJ5 Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1 0 16.631 11 7 14 7 622 71.6 7.31 2 4 5 2 6 6 1382303.094 1002032.906 6952839.281 6179022 2 2 5 5 endoplasmic reticulum;membrane;organelle lumen catalytic activity "Pf00535, Pf01755, Pf13641" 79709 ENSG00000130309.10 COLGALT1; GLT25D1 19 Collagen biosynthesis and modifying enzymes Lysine degradation; Other types of O-glycan biosynthesis 0 High Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2 0 31.928 18 10 14 10 557 64.1 5.08 1 3 9 1 3 10 18734178.19 8580836.781 10218086.5 3 6 9 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding Pf01485 25820 ENSG00000166233.14 ARIH1 15 ISG15 antiviral mechanism 0 High P52815 "39S ribosomal protein L12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" 0 24.969 32 5 13 5 198 21.3 8.87 5 2 4 7 2 4 566830.375 42696808.25 4796885.688 4621627.938 1 5 3 4 cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00542 6182 ENSG00000262814.7 MRPL12 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q96RR1 "Twinkle protein, mitochondrial OS=Homo sapiens OX=9606 GN=TWNK PE=1 SV=1" 0 64.234 21 10 13 10 684 77.1 8.98 10 1 12 1 3450514.5 25505056.75 3015726.688 3308472.362 1 8 3 5 cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus mitochondrion;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding "Pf03796, Pf13401, Pf13476, Pf13481" 56652 ENSG00000107815.7 C10orf2; TWNK 10 Transcriptional activation of mitochondrial biogenesis 0 High O00469 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Homo sapiens OX=9606 GN=PLOD2 PE=1 SV=2" 0 20.251 8 5 13 5 737 84.6 6.71 4 4 6 7 8311021.375 9834159.469 5 6 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf03171 5352 ENSG00000152952.11 PLOD2 3 Collagen biosynthesis and modifying enzymes Lysine degradation 0 High P82673 "28S ribosomal protein S35, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" 0 60.24 42 9 13 9 323 36.8 8.24 9 1 12 1 839220.1563 50988812.75 1109172.625 867479.0225 2 8 1 2 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf10213 60488 ENSG00000061794.12 MRPS35 12 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High O75131 Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1 0 37.014 21 9 13 9 537 60.1 5.85 8 2 11 2 353710.4531 20271615.25 3877772.063 2338462.45 2 5 3 3 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding;transporter activity "Pf00168, Pf07002, Pf10138" 8895 ENSG00000085719.12 CPNE3 8 Neutrophil degranulation; Glycerophospholipid biosynthesis 0 High Q8TBC3 SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2 0 23.838 20 9 13 9 707 76.3 8.28 9 13 9140593.219 6379087.125 140949.1563 487045.3115 8 3 1 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process vacuole protein binding Pf02214 92799 ENSG00000160410.14 SHKBP1 19 0 High P39656 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4 0 31.962 33 8 13 8 456 50.8 6.55 2 8 2 11 909123.0625 902100.8125 3599410.844 20504232.88 2 1 4 8 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;protein binding Pf03345 1650 ENSG00000244038.9 DDOST 1 Advanced glycosylation endproduct receptor signaling; Asparagine N-linked glycosylation; Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High O75400 Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2 0 14.391 8 6 13 5 957 108.7 7.56 1 4 4 1 6 6 2580483.5 8538242.25 9494445.188 6277636.438 2 3 4 4 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00397, Pf01846" 55660 PRPF40A 2 mRNA Splicing - Major Pathway Spliceosome 1 High P62877 E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1 0 24.228 26 3 13 3 108 12.3 6.96 2 2 3 2 3 8 6533358.5 12048708.63 10520720.14 2 4 5 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf13639" 9978 ENSG00000100387.8 RBX1 22 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of RAS by GAPs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Hedgehog 'on' state; Gap-filling DNA repair synthesis and ligation in TC-NER; Degradation of DVL; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Prolactin receptor signaling; Neddylation; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dual incision in TC-NER; Regulation of expression of SLITs and ROBOs TGF-beta signaling pathway; HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Protein processing in endoplasmic reticulum; Renal cell carcinoma; Nucleotide excision repair; Wnt signaling pathway; Oocyte meiosis; Circadian rhythm; Cell cycle 0 High P10599 Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3 0 16.304 32 3 13 3 105 11.7 4.92 2 3 2 1 2 7 2 2 3167606.75 23969932.88 10469229.09 6974765.354 2 3 3 3 cell communication;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00085, Pf00462, Pf13098, Pf13899, Pf13905" 7295 ENSG00000136810.12 TXN 9 Interconversion of nucleotide di- and triphosphates; Protein repair; TP53 Regulates Metabolic Genes; The NLRP3 inflammasome; Oxidative Stress Induced Senescence; Detoxification of Reactive Oxygen Species NOD-like receptor signaling pathway 0 High P82675 "28S ribosomal protein S5, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" 0 53.499 27 10 13 10 430 48 9.92 10 1 12 1 971894.6875 66356910.13 6292494.391 6621826.563 1 9 3 4 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity "Pf00333, Pf03719" 64969 ENSG00000144029.11 MRPS5 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 Medium Q96C24 Synaptotagmin-like protein 4 OS=Homo sapiens OX=9606 GN=SYTL4 PE=1 SV=2 0.03 1.42 1 1 13 1 671 76 8.98 1 1 1 1 3 3 3 4 74540240 115104784 286496000 403416800 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytosol;endosome;membrane metal ion binding;protein binding "Pf00168, Pf02318, Pf02891" 94121 ENSG00000102362.15 SYTL4 X Platelet degranulation 0 High Q9BSG0 Protease-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRADC1 PE=1 SV=1 0 20.993 32 6 13 6 188 21 5.47 1 6 1 12 5491261.547 10639120.38 26335797.63 4 4 6 extracellular protein binding Pf02225 84279 ENSG00000135617.3 PRADC1 2 0 High P48730 Casein kinase I isoform delta OS=Homo sapiens OX=9606 GN=CSNK1D PE=1 SV=2 0 39.721 17 7 13 1 415 47.3 9.74 7 1 12 1 2590809.5 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714" 1453 ENSG00000141551.14 CSNK1D 17 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; COPII (Coat Protein 2) Mediated Vesicle Transport; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Circadian Clock; Major pathway of rRNA processing in the nucleolus and cytosol Hippo signaling pathway; Gap junction; Hedgehog signaling pathway; Circadian rhythm 0 High Q02413 Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2 0 27.638 10 7 13 7 1049 113.7 5.03 4 3 2 7 4 2 4474534.375 2927329.5 5289034.563 4974272.969 3 1 3 4 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;membrane metal ion binding;protein binding "Pf00028, Pf01049" 1828 ENSG00000134760.5 DSG1 18 Apoptotic cleavage of cell adhesion proteins; Formation of the cornified envelope; Neutrophil degranulation Staphylococcus aureus infection 0 High Q14683 Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2 0 38.481 8 9 13 9 1233 143.1 7.64 1 8 1 2 10 1 3737004.547 20566794.5 218872 2236546.154 3 8 1 3 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;nucleus nucleotide binding;protein binding;RNA binding "Pf02463, Pf05262, Pf05557, Pf06470, Pf09726, Pf09731, Pf10186, Pf12128, Pf13175, Pf13304, Pf13476, Pf13555, Pf13558" 8243 ENSG00000072501.17 SMC1A X Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 High Q13162 Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1 0 6.028 17 4 13 2 271 30.5 6.29 1 2 3 3 1 5 3 4 2792543.25 509154.9688 2476849.438 1 1 2 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 10549 ENSG00000123131.12 PRDX4 X Neutrophil degranulation 0 High Q9NWU5 "39S ribosomal protein L22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" 0 22.857 34 7 13 7 206 23.6 9.94 7 13 74887.15625 55476102.25 1083760.625 371968.3438 1 7 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00237 29093 ENSG00000082515.17 MRPL22 5 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P37198 Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3 0 35.234 16 7 13 7 522 53.2 5.31 5 5 7 6 3033532.727 12623703.56 11560347.13 3 6 6 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus protein binding;structural molecule activity;transporter activity Pf05064 23636 ENSG00000213024.11 NUP62 19 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q9UPY3 Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3 0 49.475 10 13 13 13 1922 218.5 5.68 13 13 546976.375 175147426.8 3736597.563 2567957.656 1 12 2 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf04851, Pf14622" 23405 ENSG00000100697.14 DICER1 14 MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis MicroRNAs in cancer 0 High P17026 Zinc finger protein 22 OS=Homo sapiens OX=9606 GN=ZNF22 PE=1 SV=3 0 50.694 38 8 13 8 224 25.9 10.04 8 13 51365704.22 1852014.094 2513101 8 2 3 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 7570 ENSG00000165512.4 ZNF22 10 0 High O75691 Small subunit processome component 20 homolog OS=Homo sapiens OX=9606 GN=UTP20 PE=1 SV=3 0 39.041 6 12 13 12 2785 318.2 7.39 12 13 1649410.25 21459312.38 72942232.61 81087869.69 2 9 3 3 metabolic process;regulation of biological process cytoplasm;membrane;nucleus protein binding;RNA binding Pf07539 27340 ENSG00000120800.4 UTP20 12 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q96FX7 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1 0 40.722 42 8 13 8 289 31.4 7.36 8 1 12 1 40144283.25 2502750.688 2752507.719 6 3 2 Met-loss+Acetyl [N-Term] metabolic process nucleus catalytic activity "Pf08704, Pf12847, Pf13847" 115708 ENSG00000166166.12 TRMT61A 14 tRNA modification in the nucleus and cytosol 0 High Q08945 FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1 0 36.228 18 11 13 11 709 81 6.87 5 6 1 5 7 1 4646699.375 29706609.75 6776823.531 2066458.219 2 4 7 6 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding;RNA binding "Pf00505, Pf03531, Pf08512, Pf09011" 6749 ENSG00000149136.8 SSRP1 11 HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat 0 High O95232 Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2 0 37.316 25 7 13 7 432 51.4 9.79 2 6 3 2 8 3 1917286.25 23423079.23 213169.0781 1971409.721 3 6 1 5 Acetyl [N-Term] cell organization and biogenesis;metabolic process nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf03194 51747 ENSG00000108848.15 LUC7L3 17 0 High Q9P275 Ubiquitin carboxyl-terminal hydrolase 36 OS=Homo sapiens OX=9606 GN=USP36 PE=1 SV=4 0 48.045 14 11 12 11 1123 122.8 9.7 11 12 404348.5469 25781414.25 533272.25 2 10 1 0 High Q6NW34 Nucleolus and neural progenitor protein OS=Homo sapiens OX=9606 GN=NEPRO PE=1 SV=3 0 46.186 24 10 12 10 567 64.5 9.74 10 12 2349674.5 26568364.3 1064471.25 4840214.5 1 10 1 1 development;regulation of biological process nucleus Pf14780 25871 ENSG00000163608.14 C3orf17; NEPRO 3 0 High Q9P031 Thyroid transcription factor 1-associated protein 26 OS=Homo sapiens OX=9606 GN=CCDC59 PE=1 SV=2 0 45.18 33 7 12 7 241 28.7 9.88 7 12 427900.375 56166152.25 1002406.125 1842979.422 1 8 2 3 metabolic process;regulation of biological process nucleus protein binding;RNA binding 29080 ENSG00000133773.11 CCDC59 12 Surfactant metabolism; Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) 0 High Q9H089 Large subunit GTPase 1 homolog OS=Homo sapiens OX=9606 GN=LSG1 PE=1 SV=2 0 39.512 18 8 12 8 658 75.2 6.38 8 12 16467627 6 transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;nucleotide binding "Pf01926, Pf02421, Pf04548" 55341 ENSG00000041802.10 LSG1 3 Ribosome biogenesis in eukaryotes 0 High Q9BRU9 rRNA-processing protein UTP23 homolog OS=Homo sapiens OX=9606 GN=UTP23 PE=1 SV=2 0 40.649 39 6 12 6 249 28.4 10.07 6 12 768894.375 35735521.25 44845.5625 1 6 1 metabolic process nucleus protein binding;RNA binding Pf04900 84294 ENSG00000147679.11 UTP23 8 0 High Q9BQ75 Protein CMSS1 OS=Homo sapiens OX=9606 GN=CMSS1 PE=1 SV=2 0 25.248 29 8 12 7 279 31.9 9.19 8 1 11 1 4147467.75 66526297.5 437013.9688 2 8 1 nucleus nucleotide binding;RNA binding "Pf00270, Pf14617" 84319 ENSG00000184220.11 CMSS1 3 1 High Q9Y4C8 Probable RNA-binding protein 19 OS=Homo sapiens OX=9606 GN=RBM19 PE=1 SV=3 0 42.279 12 9 12 9 960 107.3 6.54 9 12 28841452.17 426045.5 2203.678467 9 1 1 development;regulation of biological process chromosome;cytoplasm;membrane;nucleus RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 9904 ENSG00000122965.10 RBM19 12 0 High O15504 Nucleoporin-like protein 2 OS=Homo sapiens OX=9606 GN=NUPL2 PE=1 SV=1 0 41.918 31 8 12 8 423 44.8 9.19 8 12 5187358.172 37263300.63 5158576.293 4869090.732 4 8 5 5 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus metal ion binding;protein binding;RNA binding;transporter activity Pf00642 11097 ENSG00000136243.16 NUPL2 7 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q96CT7 Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1 0 26.054 42 10 12 10 223 25.8 9.54 10 12 80354.73438 54105529.38 822648.875 1 9 1 cell division cytoplasm;cytoskeleton RNA binding Pf06244 115098 ENSG00000007080.10 CCDC124 19 0 High Q96CB9 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2 0 25.492 21 6 12 6 384 43.1 8.18 6 12 37221609.75 433055.2813 399129 6 1 1 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding "Pf01189, Pf12847, Pf13659" 387338 ENSG00000117481.10 NSUN4 1 rRNA modification in the mitochondrion 0 High Q9ULW3 Activator of basal transcription 1 OS=Homo sapiens OX=9606 GN=ABT1 PE=1 SV=1 0 39.472 49 8 12 8 272 31.1 9.88 8 12 175467.2031 34774697 2063662.719 7238598.547 1 8 2 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding Pf14259 29777 ENSG00000146109.4 ABT1 6 0 High Q9NYU1 UDP-glucose:glycoprotein glucosyltransferase 2 OS=Homo sapiens OX=9606 GN=UGGT2 PE=1 SV=4 0 24.504 8 11 12 9 1516 174.6 6.89 11 12 294036.6563 2207456.75 8306431.75 9146470.016 1 2 2 10 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;organelle lumen catalytic activity;protein binding "Pf01501, Pf06427" 55757 ENSG00000102595.19 UGGT2 13 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 2 High Q709F0 Acyl-CoA dehydrogenase family member 11 OS=Homo sapiens OX=9606 GN=ACAD11 PE=1 SV=3 0 41.223 18 9 12 9 780 87.2 8.02 9 12 1468038.938 27829086.38 6205082 380074.4219 2 8 1 2 0 High P02747 Complement C1q subcomponent subunit C OS=Homo sapiens OX=9606 GN=C1QC PE=1 SV=3 0 7.816 7 1 12 1 245 25.8 8.41 1 1 1 1 6 5 6204080.5 32321931 16285202 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane catalytic activity;protein binding "Pf00229, Pf00386" 714 ENSG00000159189.11 C1QC 1 Regulation of Complement cascade; Classical antibody-mediated complement activation Chagas disease (American trypanosomiasis); Prion diseases; Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Staphylococcus aureus infection 0 High Q9H2W6 "39S ribosomal protein L46, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" 0 27.86 25 7 12 7 279 31.7 7.05 7 12 87121741.5 1815437.641 998338.9375 7 3 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome catalytic activity;structural molecule activity Pf11788 26589 ENSG00000259494.1 MRPL46 15 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q99755 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1 0 36.395 25 9 12 6 562 62.6 8.21 9 12 534930.5 31554066.89 1019250.813 1238766.969 1 8 1 2 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding Pf01504 8394 ENSG00000143398.19 PIP5K1A 1 "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" Endocytosis; Phospholipase D signaling pathway; Phosphatidylinositol signaling system; Inositol phosphate metabolism; Choline metabolism in cancer; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Metabolic pathways 3 High P53350 Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1 0 26.204 15 7 12 7 603 68.2 8.91 6 1 3 7 1 4 2101.209229 14722261.63 2616495.688 3269901.531 1 6 3 5 cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf00659, Pf07714, Pf14531" 5347 ENSG00000166851.14 PLK1 16 "Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Polo-like kinase mediated events; Phosphorylation of Emi1; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Condensation of Prophase Chromosomes; RHO GTPases Activate Formins; Activation of NIMA Kinases NEK9, NEK6, NEK7; Golgi Cisternae Pericentriolar Stack Reorganization; The role of GTSE1 in G2/M progression after G2 checkpoint; Mitotic Metaphase/Anaphase Transition; Mitotic Telophase/Cytokinesis" FoxO signaling pathway; Progesterone-mediated oocyte maturation; Oocyte meiosis; Cell cycle 0 High P17028 Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4 0 39.615 30 9 12 8 368 42.1 6.21 9 12 41818716.63 1612901.375 423687.5625 8 2 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf02023, Pf13465" 7572 ENSG00000172466.15 ZNF24 18 1 High Q9Y3I1 F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1 0 21.104 14 6 12 6 522 58.5 6.55 4 5 5 7 616441.6875 2415682.75 15032222.56 12270181.88 1 1 5 5 metabolic process;regulation of biological process;transport cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding "Pf11566, Pf12937" 25793 ENSG00000100225.17 FBXO7 22 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q9H6R0 ATP-dependent RNA helicase DHX33 OS=Homo sapiens OX=9606 GN=DHX33 PE=1 SV=2 0 29.901 15 9 12 9 707 78.8 8.91 9 1 11 1 182269.0977 25272021.38 402622.9697 301491.0938 2 9 2 1 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717, Pf13401" 56919 ENSG00000005100.12 DHX33 17 NOD-like receptor signaling pathway 0 High Q53GS9 U4/U6.U5 tri-snRNP-associated protein 2 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2 0 34.293 18 8 12 8 565 65.3 8.91 8 12 1382407.281 36152023.88 1695372.75 2 8 2 cell division;cell organization and biogenesis;metabolic process nucleus;spliceosomal complex catalytic activity;metal ion binding "Pf00443, Pf02148" 10713 ENSG00000168883.19 USP39 2 mRNA Splicing - Major Pathway Spliceosome 0 High Q9UQE7 Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2 0 41.325 10 11 12 11 1217 141.5 7.18 9 1 1 10 1 1 11146383.59 81874385.63 176070534.2 7 5 4 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf01496, Pf02463, Pf04111, Pf06470, Pf10168, Pf12128, Pf13304, Pf13476, Pf13555" 9126 ENSG00000108055.9 SMC3 10 Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 High Q9NSI2 Protein FAM207A OS=Homo sapiens OX=9606 GN=FAM207A PE=1 SV=2 0 36.601 36 7 12 7 230 25.4 11.08 6 1 11 1 1184579.539 33420911 220785.2544 252476.8345 3 7 2 2 protein binding Pf15341 85395 ENSG00000160256.12 FAM207A 21 0 High Q9Y3D3 "28S ribosomal protein S16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" 0 37.785 54 6 12 6 137 15.3 9.5 6 1 11 1 571457.625 90953186.75 3133266.313 691510.8125 2 6 2 1 cell organization and biogenesis;metabolic process cytosol;membrane;mitochondrion;ribosome protein binding;structural molecule activity Pf00886 51021 ENSG00000182180.13 MRPS16 10 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q13148 TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1 0 21.201 29 7 12 7 414 44.7 6.19 2 4 1 3 2 5 1 4 397436.8438 8867086.344 700667.875 1984952.25 1 4 1 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 23435 ENSG00000120948.16 TARDBP 1 0 High Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1 0 34.846 8 11 12 11 1792 201.4 9.64 11 1 11 1 34497927.47 2367554.031 1075452.133 8 4 3 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00098, Pf08783, Pf10243, Pf13639, Pf13696, Pf13920, Pf13923, Pf14634, Pf15227" 5930 ENSG00000122257.18 RBBP6 16 Antigen processing: Ubiquitination & Proteasome degradation 0 High Q9H7B2 Ribosome production factor 2 homolog OS=Homo sapiens OX=9606 GN=RPF2 PE=1 SV=2 0 45.298 30 8 12 8 306 35.6 9.99 8 12 1424173.938 82700046.5 170101.4375 777528.8555 2 7 1 4 cell organization and biogenesis;metabolic process;regulation of biological process nucleus RNA binding Pf04427 84154 ENSG00000197498.12 RPF2 6 0 High P55769 NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3 0 27.484 45 6 12 6 128 14.2 8.46 1 6 1 1 10 1 260826.3125 85017622.06 2420935.344 1549117.063 1 6 2 2 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex protein binding;RNA binding Pf01248 4809 ENSG00000100138.13 NHP2L1; SNU13 22 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Ribosome biogenesis in eukaryotes 0 High Q02241 Kinesin-like protein KIF23 OS=Homo sapiens OX=9606 GN=KIF23 PE=1 SV=3 0 53.671 15 10 12 10 960 110 8.51 10 12 46839489.13 4190101.781 4135267.719 9 5 5 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf02463, Pf03938, Pf05852, Pf11559, Pf12329, Pf15294" 9493 ENSG00000137807.13 KIF23 15 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Mitotic Telophase/Cytokinesis MicroRNAs in cancer 0 High O94832 Unconventional myosin-Id OS=Homo sapiens OX=9606 GN=MYO1D PE=1 SV=2 0 29.19 11 9 12 9 1006 116.1 9.39 5 4 2 5 5 2 581259.0078 19474409.56 16014901.19 10780032.69 3 5 5 5 regulation of biological process;transport cytosol;endoplasmic reticulum;endosome;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 4642 ENSG00000176658.16 MYO1D 17 0 High Q9P0K7 Ankycorbin OS=Homo sapiens OX=9606 GN=RAI14 PE=1 SV=2 0 29.057 14 10 12 10 980 110 6.21 1 7 3 1 8 3 5374588.75 5018410.422 3576256.531 4 7 8 cell differentiation;metabolic process cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus protein binding "Pf00023, Pf03961, Pf04111, Pf12796, Pf13606, Pf13637, Pf13857" 26064 ENSG00000039560.13 RAI14 5 0 High P09234 U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1 0 25.989 27 4 12 4 159 17.4 9.67 4 1 1 10 1 1 65585551 5887438 3314902.375 4 2 2 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding Pf06220 6631 ENSG00000124562.9 SNRPC 6 mRNA Splicing - Major Pathway Spliceosome 0 High Q14152 Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1 0 36.943 9 11 12 11 1382 166.5 6.79 10 1 11 1 102234.5859 17006930.34 406410.9063 559826.4219 1 10 1 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;structural molecule activity Pf01399 8661 ENSG00000107581.12 EIF3A 10 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High P98160 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4 0 25.479 4 10 12 10 4391 468.5 6.51 1 3 8 1 3 8 165176.9688 13004179.63 4333332.813 4387221.938 1 3 5 6 cell differentiation;cell growth;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen metal ion binding;protein binding "Pf00008, Pf00047, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf07686, Pf12785, Pf13385, Pf13895, Pf13927" 3339 ENSG00000142798.17 HSPG2 1 "Integrin cell surface interactions; Defective B4GALT7 causes EDS, progeroid type; Amyloid fiber formation; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Non-integrin membrane-ECM interactions; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Laminin interactions; Degradation of the extracellular matrix; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD" Hepatitis B; Proteoglycans in cancer; ECM-receptor interaction 0 High Q96QE5 "Transcription elongation factor, mitochondrial OS=Homo sapiens OX=9606 GN=TEFM PE=1 SV=1" 0 41.375 29 7 12 7 360 41.7 9.32 7 12 614704.918 30460716.88 416257.9434 21962.39307 2 7 2 2 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;enzyme regulator activity;protein binding;RNA binding Pf12836 79736 ENSG00000172171.10 TEFM 17 0 High Q7Z7F7 "39S ribosomal protein L55, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL55 PE=1 SV=1" 0 37.564 44 6 12 6 128 15.1 11.15 6 12 278090.875 39851495 1 5 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf09776 128308 ENSG00000162910.18 MRPL55 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High P49327 Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3 0 25.759 5 11 12 11 2511 273.3 6.44 2 1 4 5 2 1 4 5 3947355.281 19596510.5 3544626.569 2644405.719 3 4 7 8 Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00106, Pf00107, Pf00108, Pf00109, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf13602, Pf14765" 2194 ENSG00000169710.8 FASN 17 ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism; Activation of gene expression by SREBF (SREBP) Insulin signaling pathway; Fatty acid biosynthesis; AMPK signaling pathway; Metabolic pathways; Fatty acid metabolism 0 High P24666 Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3 0 16.682 30 4 12 4 158 18 6.74 1 4 1 1 1 8 1 2 334142.6875 20668914.13 3101951.5 2704546.445 1 4 1 1 metabolic process cytoplasm;cytosol;membrane catalytic activity;protein binding Pf01451 52 ENSG00000143727.15 ACP1 2 Thiamine metabolism; Adherens junction; Metabolic pathways 0 High P78345 Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2 0 53.175 38 10 12 10 283 31.8 9.92 10 12 1286628.344 59583095 150968.0781 1289109.875 2 9 1 1 metabolic process nucleus catalytic activity;protein binding Pf01248 10557 ENSG00000152464.14 RPP38 10 Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High Q9P035 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2 0 20.085 15 5 11 5 362 43.1 8.94 2 3 4 2 5 4 942022.875 5951692.813 6854177.125 5243277.375 2 3 4 4 metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding "Pf04387, Pf04969" 51495 ENSG00000074696.12 PTPLAD1; HACD3 15 Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism 0 High Q8IWZ3 Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1 0 31.682 4 9 11 2 2542 269.3 5.73 9 11 208360.9531 3027143.625 8495.515625 1 2 1 defense response;response to stimulus cytoplasm protein binding;RNA binding "Pf00013, Pf00023, Pf12796, Pf13014, Pf13606, Pf13637, Pf13857" 54882; 404734 ENSG00000131503.20 ANKHD1; ANKHD1-EIF4EBP3 5 0 High Q9Y450 HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1 0 45.654 25 10 11 10 684 75.4 6.61 10 11 335982.5 15411065.81 7666.690918 1 7 1 metabolic process;regulation of biological process;response to stimulus cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144, Pf08938" 10767 ENSG00000112339.14 HBS1L 6 mRNA decay by 3' to 5' exoribonuclease mRNA surveillance pathway; Legionellosis 0 High Q96A35 "39S ribosomal protein L24, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" 0 27.525 36 8 11 8 216 24.9 9.29 7 1 1 9 1 1 563995.6406 38398607.25 1510822.438 990721.2871 2 7 2 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf00467 79590 ENSG00000143314.12 MRPL24 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q8IYB3 Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2 0 16.534 6 5 11 5 904 102.3 11.84 3 1 5 5 1 5 2962548 279980.5313 8678024.125 8226546.938 3 1 3 5 metabolic process;transport cytosol;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf01480 10250 ENSG00000133226.16 SRRM1 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway; RNA transport 0 High Q99700 Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2 0 41.786 9 8 11 8 1313 140.2 9.57 1 7 1 1 9 1 1938625.375 15188152 8099174.438 1348310.102 3 6 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;Golgi;membrane protein binding;RNA binding "Pf06741, Pf07145, Pf09770, Pf14438" 6311 ENSG00000204842.14 ATXN2 12 0 High Q8NDF8 Terminal nucleotidyltransferase 4A OS=Homo sapiens OX=9606 GN=TENT4B PE=1 SV=2 0 50.037 20 8 11 8 572 63.2 8.98 8 11 212141.1094 21185695.63 464300.75 1 7 1 cell division;metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;RNA binding "Pf01909, Pf03828, Pf04928" 64282 PAPD5 16 RNA degradation 0 High Q14119 Vascular endothelial zinc finger 1 OS=Homo sapiens OX=9606 GN=VEZF1 PE=1 SV=2 0 32.408 13 7 11 4 521 56.9 9.52 7 11 5883230.438 1632171.016 4 2 defense response;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding;protein binding Pf13465 7716 ENSG00000136451.8 VEZF1 17 0 High P49368 T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4 0 24.398 18 9 11 9 545 60.5 6.49 1 3 6 1 4 6 5182789 9935979.625 5288589.156 4 6 6 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane nucleotide binding;protein binding;RNA binding Pf00118 7203 ENSG00000163468.14 CCT3 1 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High Q15149 Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3 0 18.774 2 9 11 8 4684 531.5 5.96 5 1 3 6 2 3 1778168.563 740352.0625 2087909.531 5 1 3 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane protein binding;RNA binding;structural molecule activity "Pf00307, Pf00681, Pf03501, Pf07812" 5339 ENSG00000178209.14 PLEC 8 Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly 0 High Q5VTL8 Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1 0 14.751 12 7 11 7 546 64.4 10.54 2 4 3 2 4 5 1167363.977 12154525.13 6065645.75 2644039.766 2 4 5 4 metabolic process nucleus;spliceosomal complex RNA binding Pf03371 55119 ENSG00000134186.11 PRPF38B 1 Spliceosome 0 High Q9P2J5 "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS PE=1 SV=2" 0 29.703 10 10 11 10 1176 134.4 7.3 10 11 841725.125 48610239.5 3949309.469 4284850.129 3 10 4 4 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;vacuole catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00133, Pf01406, Pf08264, Pf09334" 51520 ENSG00000133706.17 LARS 5 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High P33992 DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5 0 23.468 10 7 11 7 734 82.2 8.37 5 1 3 6 1 4 16622650.47 1980100.945 1416285.414 6 3 3 cell division;metabolic process membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 4174 ENSG00000100297.15 MCM5 22 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High Q9P2E5 Chondroitin sulfate glucuronyltransferase OS=Homo sapiens OX=9606 GN=CHPF2 PE=2 SV=2 0 28.132 19 11 11 11 772 85.9 7.83 11 11 14259715.53 3137695.469 21980756.34 11837704.13 3 3 3 8 metabolic process Golgi;membrane catalytic activity "Pf02434, Pf05679" 54480 ENSG00000033100.16 CHPF2 7 Chondroitin sulfate biosynthesis Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High Q5SW79 Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1 0 53.046 9 10 11 10 1584 175.2 7.11 10 11 17901052.75 1073538.25 3849968.688 7 1 3 cytoplasm;cytoskeleton;cytosol;membrane protein binding "Pf00498, Pf15308" 9859 ENSG00000276725.4; ENSG00000143702.15 CEP170 1; CHR_HSCHR1_3_CTG32_1 0 High Q14966 Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2 0 37.242 7 10 11 10 1978 220.5 6.38 10 11 81361.25 37422817.13 4021915.359 15718439 1 8 2 1 metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;metal ion binding;RNA binding "Pf00076, Pf12171, Pf13893, Pf14259" 27332 ENSG00000075292.18 ZNF638 2 Transcriptional regulation of white adipocyte differentiation 0 High Q9P0U4 CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2 0 16.537 12 7 11 7 656 75.7 8.24 4 5 6 5 22170.25 10856984.16 6360288.719 1 4 6 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00628, Pf02008, Pf12269" 30827 ENSG00000154832.14 CXXC1 18 XBP1(S) activates chaperone genes 0 High P82914 "28S ribosomal protein S15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" 0 22.818 26 7 11 7 257 29.8 10.48 7 1 10 1 59587381.75 1904754.438 745006.2813 7 2 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus;ribosome RNA binding;structural molecule activity Pf00312 64960 ENSG00000116898.11 MRPS15 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P78559 Microtubule-associated protein 1A OS=Homo sapiens OX=9606 GN=MAP1A PE=1 SV=6 0 38.754 6 10 11 9 2803 305.3 4.92 10 11 192965.1094 46061218.38 18651 2 7 1 cell organization and biogenesis cytoplasm;cytoskeleton protein binding;structural molecule activity "Pf12072, Pf12128" 4130 ENSG00000166963.12 MAP1A 15 1 High Q9Y4Z0 U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1 0 31.96 36 6 11 6 139 15.3 9.99 6 11 906507.4375 27880153.5 152519.5313 6131.898926 1 7 1 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 25804 ENSG00000130520.10 LSM4 19 mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease Spliceosome; RNA degradation 0 High O15381 Nuclear valosin-containing protein-like OS=Homo sapiens OX=9606 GN=NVL PE=1 SV=1 0 39.665 15 9 11 9 856 95 6.48 9 11 270482.1875 22720540.38 792271.2188 5248418.125 1 8 2 3 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf06068, Pf06414, Pf07724, Pf07726, Pf07728, Pf13173, Pf13191, Pf13207, Pf13401" 4931 ENSG00000143748.17 NVL 1 Ribosome biogenesis in eukaryotes 0 High Q9UPP1 Histone lysine demethylase PHF8 OS=Homo sapiens OX=9606 GN=PHF8 PE=1 SV=3 0 36.242 12 9 11 9 1060 117.8 8.72 8 1 10 1 948497.8906 27257455.19 1056728.5 1842221.922 2 8 1 3 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00628, Pf02373, Pf13621" 23133 ENSG00000172943.19 PHF8 X HDMs demethylate histones; Condensation of Prophase Chromosomes 0 High P29372 DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3 0 50.995 39 8 11 8 298 32.8 9.57 8 11 401616.7266 41458256.25 56402954.22 46509069.38 2 8 3 3 metabolic process;response to stimulus cytoplasm;mitochondrion;nucleus catalytic activity;DNA binding;protein binding Pf02245 4350 ENSG00000103152.11 MPG 16 Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1 Base excision repair 0 High Q58FF8 Putative heat shock protein HSP 90-beta 2 OS=Homo sapiens OX=9606 GN=HSP90AB2P PE=1 SV=2 0 21.107 13 5 11 1 381 44.3 4.84 2 2 4 2 4 5 625093.0625 1 metabolic process;response to stimulus cytoplasm nucleotide binding;protein binding "Pf00183, Pf02518" 391634 HSP90AB2P 4 0 High Q9Y3B9 RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2 0 18.761 25 7 11 7 282 31.5 5.52 7 1 10 1 41396.21484 49085775.5 895239.75 590754.875 1 7 1 1 metabolic process Pf07890 51018 ENSG00000067533.5 RRP15 1 0 High Q99497 Protein/nucleic acid deglycase DJ-1 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2 0 12.603 24 4 11 4 189 19.9 6.79 2 1 3 3 3 1 3 4 1795349.969 62261451.38 4911061.313 4119111.438 3 3 4 4 cell communication;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding "Pf01965, Pf13278" 11315 ENSG00000116288.12 PARK7 1 Parkinson's disease 0 High Q9Y490 Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3 0 26.808 5 9 11 9 2541 269.6 6.07 2 6 2 2 7 2 344325.7448 19146072.13 3808840.469 1803417.063 2 6 5 5 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytoskeleton;cytosol;extracellular;membrane protein binding;structural molecule activity "Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379" 7094 ENSG00000137076.20 TLN1 9 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Smooth Muscle Contraction; XBP1(S) activates chaperone genes; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling Rap1 signaling pathway; HTLV-I infection; Focal adhesion; Platelet activation 0 High A4D1E9 GTP-binding protein 10 OS=Homo sapiens OX=9606 GN=GTPBP10 PE=1 SV=1 0 40.623 30 10 11 10 387 42.9 9.03 10 11 277303.9688 42815763.63 176502.043 83781.31348 1 10 2 2 metabolic process chromosome;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00009, Pf01018, Pf01926, Pf02421, Pf03029, Pf10662" 85865 ENSG00000105793.15 GTPBP10 7 0 High P49757 Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2 0 35.653 17 7 11 7 651 70.8 8.51 7 11 179842.9219 25999592.88 210186.9844 1048850.188 1 7 1 2 cell differentiation;cell division;cell organization and biogenesis;cell proliferation;development;regulation of biological process cytoplasm;endosome;membrane;nucleus protein binding "Pf00640, Pf06311, Pf08416" 8650 ENSG00000133961.19 NUMB 14 Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; Degradation of GLI1 by the proteasome; Recycling pathway of L1 Notch signaling pathway 0 High Q99733 Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1 0 14.14 7 2 10 1 375 42.8 4.69 2 1 8 2 cell organization and biogenesis cytoplasm;nucleus protein binding;RNA binding Pf00956 4676 ENSG00000273562.4; ENSG00000205531.12 NAP1L4 11; CHR_HSCHR11_1_CTG7 0 High Q86UK7 E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1 0 37.515 12 10 10 10 904 98.6 8.4 10 10 333993.7188 23548026.38 1066286.688 1483803.695 1 9 2 4 metabolic process;regulation of biological process catalytic activity;metal ion binding;protein binding;RNA binding 90850 ZNF598 16 0 High P46977 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens OX=9606 GN=STT3A PE=1 SV=2 0 13.555 7 6 10 4 705 80.5 8.07 1 6 2 8 37584344.88 3678475.75 13121872.47 2 3 4 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf02516 3703 ENSG00000134910.12 STT3A 11 Asparagine N-linked glycosylation N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q9Y3Y2 Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2 0 31.667 31 6 10 6 248 26.4 12.23 5 1 9 1 2225236.047 98988763 3 5 metabolic process;regulation of biological process;transport nucleus DNA binding;nucleotide binding;protein binding;RNA binding Pf13865 26097 ENSG00000160679.12 CHTOP 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing 0 High O75818 Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3 0 37.815 24 7 10 7 363 41.8 6.67 7 10 26341373.25 947459.1875 597507.5625 5 1 1 metabolic process nucleus catalytic activity Pf08584 10799 ENSG00000124787.13 RPP40 6 Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High Q00577 Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2 0 42.336 52 8 10 6 322 34.9 6.44 8 10 5675496.25 987419 3 1 cell differentiation;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding;translation regulator activity Pf04845 5813 ENSG00000185129.5 PURA 5 0 High Q9HA77 "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" 0 13.502 12 7 10 7 564 62.2 8.34 5 3 7 3 539519.9219 19352655.25 7105835.75 4183442.469 2 4 7 6 metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding "Pf00133, Pf01406, Pf01921, Pf09334" 79587 ENSG00000134905.16 CARS2 13 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q96K58 Zinc finger protein 668 OS=Homo sapiens OX=9606 GN=ZNF668 PE=1 SV=3 0 39.851 26 10 10 10 619 67.8 8.9 10 10 63725.42188 18439022.5 388508.6875 1 8 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 79759 ZNF668 16 Generic Transcription Pathway 0 High Q9Y3B7 "39S ribosomal protein L11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" 0 18.404 34 6 10 6 192 20.7 9.91 6 1 1 8 1 1 423145.875 47799476.5 671079.4375 2009801.125 1 6 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity "Pf00298, Pf03946" 65003 ENSG00000174547.13 MRPL11 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P13747 "HLA class I histocompatibility antigen, alpha chain E OS=Homo sapiens OX=9606 GN=HLA-E PE=1 SV=4" 0 31.214 16 4 10 1 358 40 5.83 4 10 0 High O95707 Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2 0 35.193 41 7 10 7 220 25.4 10.07 7 10 737385.5 26737618 1419759.25 1 6 1 metabolic process nucleus catalytic activity;protein binding;RNA binding Pf01868 10775 ENSG00000105171.9 POP4 19 tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High Q15072 Zinc finger protein OZF OS=Homo sapiens OX=9606 GN=ZNF146 PE=1 SV=2 0 25.71 27 7 10 7 292 33.3 8.88 7 10 19133810.63 222409.0313 391730.4375 7 1 1 regulation of biological process cytosol;nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 7705 ENSG00000167635.11 ZNF146 19 0 High O75940 Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1 0 43.755 43 6 10 6 238 26.7 7.24 6 10 87804504.75 933654.625 805084.0502 7 1 3 cell death;metabolic process cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding Pf06003 10285 ENSG00000119953.12 SMNDC1 10 mRNA Splicing - Major Pathway Spliceosome 0 High O15078 Centrosomal protein of 290 kDa OS=Homo sapiens OX=9606 GN=CEP290 PE=1 SV=2 0 19.497 4 9 10 9 2479 290.2 5.95 2 3 4 3 3 4 5554.059082 56434911.63 4101345.188 2619366.75 1 4 4 5 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen protein binding 80184 ENSG00000198707.14 CEP290 12 Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High B5ME19 Eukaryotic translation initiation factor 3 subunit C-like protein OS=Homo sapiens OX=9606 GN=EIF3CL PE=3 SV=1 0 35.12 12 8 10 8 914 105.4 5.64 1 5 1 3 1 5 1 3 309002356 1644637.906 1318820.321 5 3 4 metabolic process cytoplasm protein binding;RNA binding "Pf01399, Pf05470" 728689 ENSG00000205609.12 EIF3CL 16 RNA transport 0 High Q5F1R6 DnaJ homolog subfamily C member 21 OS=Homo sapiens OX=9606 GN=DNAJC21 PE=1 SV=2 0 37.049 24 9 10 9 531 62 5.47 9 10 25514410.5 4864054.125 6362502 7 3 1 metabolic process cytoplasm;nucleus;ribosome DNA binding;metal ion binding;protein binding;RNA binding "Pf00226, Pf12171, Pf12874, Pf13868, Pf13892" 134218 ENSG00000168724.14 DNAJC21 5 0 High Q9H0H5 Rac GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RACGAP1 PE=1 SV=1 0 44.391 18 8 10 8 632 71 8.88 8 10 20173798.5 5 cell differentiation;cell division;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00130, Pf00620, Pf07888" 29127 ENSG00000161800.12 RACGAP1 12 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Rho GTPase cycle; MHC class II antigen presentation 0 High O75165 DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5 0 34.561 6 9 10 9 2243 254.3 6.74 1 9 1 9 2095724.313 111747222.8 563376.5625 261221 2 7 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;transport cytosol;endosome;membrane protein binding "Pf00226, Pf14237" 23317 ENSG00000138246.15 DNAJC13 3 Neutrophil degranulation 0 High Q05519 Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1 0 28.053 23 5 10 5 484 53.5 10.52 1 4 1 2 1 4 2 3 952040.7969 12673780.63 2432949.875 2027906.063 2 4 2 2 Met-loss+Acetyl [N-Term] metabolic process;transport nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 9295 ENSG00000116754.13 SRSF11 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway 0 High Q7LGA3 Heparan sulfate 2-O-sulfotransferase 1 OS=Homo sapiens OX=9606 GN=HS2ST1 PE=1 SV=1 0 21.377 25 7 10 7 356 41.9 8.69 7 3 7 3 1957862.766 28783133.63 12084142.63 8767986.543 3 7 4 5 metabolic process Golgi;membrane catalytic activity Pf03567 9653 ENSG00000153936.16 HS2ST1 1 HS-GAG biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 High Q96I24 Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2 0 27.687 20 9 10 9 572 61.6 8.38 6 2 2 6 2 2 97551.29883 190034756.6 2480685.5 5660356.438 2 7 2 3 metabolic process;regulation of biological process cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf07650, Pf13014" 8939 ENSG00000107164.15 FUBP3 9 0 High P09543 "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" 0 40.224 23 9 10 9 421 47.5 9.07 7 3 7 3 639393.25 8559151.813 1623873.297 2485787.688 1 5 3 4 cell communication;cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;membrane catalytic activity;nucleotide binding;RNA binding "Pf01591, Pf05881, Pf08302, Pf13207, Pf13671" 1267 ENSG00000173786.16 CNP 17 0 High Q15650 Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4 0 33.267 16 8 10 8 581 66.1 7.85 8 10 196077.4688 28864896 147458.4023 2 8 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf02614, Pf04266, Pf06221" 9325 ENSG00000103671.9 TRIP4 15 0 High O14617 AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1 0 29.459 7 5 10 5 1153 130.1 8.48 3 3 2 5 3 2 345055.4688 5195320.5 2521906.25 1660345.504 1 2 4 4 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;Golgi;membrane transporter activity "Pf01602, Pf06375" 8943 ENSG00000065000.15 AP3D1 19 Lysosome 0 High P69905 Hemoglobin subunit alpha OS=Homo sapiens OX=9606 GN=HBA1 PE=1 SV=2 0 9.726 15 2 10 2 142 15.2 8.68 2 10 14492097 5097852.25 1302641 1786557.875 2 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;membrane;organelle lumen antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 3040; 3039 ENSG00000206172.8; ENSG00000188536.12 HBA2; HBA1 16 Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide Malaria; African trypanosomiasis 0 High P01599 Immunoglobulin kappa variable 1-17 OS=Homo sapiens OX=9606 GN=IGKV1-17 PE=1 SV=2 0.001 3.253 13 1 10 1 117 12.8 8.68 1 1 6 4 1004844 22821000.5 23680416.5 1 1 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane catalytic activity "Pf00047, Pf07679, Pf07686, Pf13927" 28937 ENSG00000281978.1; ENSG00000240382.3 IGKV1-17 2; CHR_HG2290_PATCH FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis 0 High O14950 Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2 0 15.332 27 6 10 6 172 19.8 4.84 4 4 2 4 4 2 544797.3125 20956813.72 17925324.75 3532322.876 1 5 4 4 regulation of biological process;response to stimulus cytosol metal ion binding;protein binding "Pf00036, Pf13202, Pf13405, Pf13833" 103910; 10627 ENSG00000118680.12 MYL12B; MYL12A 18 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Focal adhesion; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Platelet activation 0 High Q8IV48 3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3 0 22.909 24 7 10 7 349 40 6.7 7 10 1094122.078 28100875.38 924579.3438 2083523 3 7 2 1 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;metal ion binding;protein binding;RNA binding Pf00929 90459 ENSG00000104626.14 ERI1 8 Major pathway of rRNA processing in the nucleolus and cytosol 0 High P10515 "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" 0 7.634 4 3 10 3 647 69 7.84 3 1 9 1 7623165.625 1833754.125 1660999.125 612506.375 3 2 1 1 metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 1737 ENSG00000150768.15 DLAT 11 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); Carbon metabolism; Pyruvate metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High Q8N1G4 Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1 0 30.723 14 7 10 7 583 63.4 8.28 6 1 9 1 25001.59375 28555122.5 1146831.563 1 6 2 metabolic process catalytic activity;protein binding;RNA binding "Pf03483, Pf12799, Pf13855" 57470 ENSG00000130764.9 LRRC47 1 0 High Q9NXG2 THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2 0 36.458 33 7 10 7 353 39.3 7.88 7 10 15665342.25 484492.0625 4 1 Met-loss+Acetyl [N-Term] metabolic process protein binding;RNA binding Pf02926 55623 ENSG00000066654.13 THUMPD1 16 rRNA modification in the nucleus and cytosol 0 High O00488 Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2 0 22.841 53 4 10 4 134 15.2 9.82 4 10 229575.6406 50953606.5 29667747.34 37531184.47 1 4 1 1 metabolic process;regulation of biological process;transport cytosol;nucleus DNA binding;metal ion binding;protein binding Pf12171 51042 ENSG00000142684.8 ZNF593 1 0 High Q9BVI4 Nucleolar complex protein 4 homolog OS=Homo sapiens OX=9606 GN=NOC4L PE=1 SV=1 0 42.537 19 6 10 6 516 58.4 7.49 5 1 9 1 20709952 516119.8125 891940.375 4 1 1 metabolic process membrane;nucleus protein binding;RNA binding "Pf03914, Pf14838" 79050 ENSG00000184967.6 NOC4L 12 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q12899 Tripartite motif-containing protein 26 OS=Homo sapiens OX=9606 GN=TRIM26 PE=1 SV=1 0 29.527 18 8 9 8 539 62.1 5.03 8 9 714789.9063 22373893.5 290491.3438 2 7 1 Met-loss+Acetyl [N-Term] defense response;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00097, Pf00622, Pf00643, Pf05290, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227" 7726 ENSG00000230230.7; ENSG00000231002.7; ENSG00000228881.7; ENSG00000137313.15; ENSG00000231641.9; ENSG00000234127.8; ENSG00000226060.7; ENSG00000234046.7 TRIM26 6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1 Interferon gamma signaling 0 High O75531 Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1 0 17.698 45 4 9 4 89 10.1 6.09 1 2 2 3 1 2 2 4 780441.125 5208862.25 7668155.563 6981082.313 1 2 4 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;nucleus DNA binding;protein binding Pf02961 8815 ENSG00000175334.7 BANF1 11 2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High P0DPK5 Putative histone H3.X OS=Homo sapiens OX=9606 PE=5 SV=1 0.003 2.461 9 2 9 1 147 16.5 11.39 2 1 2 2 3 4 134131305.2 13732346 11753502 1 1 1 0 High Q15464 SH2 domain-containing adapter protein B OS=Homo sapiens OX=9606 GN=SHB PE=1 SV=2 0 20.271 18 8 9 8 509 55 8.9 1 7 1 8 451115443.4 4891028.063 13369854.03 3 5 8 cell death;cell differentiation;cell proliferation;development;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding Pf00017 6461 ENSG00000107338.9 SHB 9 VEGFA-VEGFR2 Pathway 0 High Q92734 Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2 0 25.002 21 6 9 6 400 43.4 5.1 3 1 4 3 1 5 5286975.125 64556041.25 5383940.313 6383193.25 3 3 3 3 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane protein binding;signal transducer activity "Pf00564, Pf08232" 10342 ENSG00000114354.13 TFG 3 COPII (Coat Protein 2) Mediated Vesicle Transport Pathways in cancer; Thyroid cancer 0 High P04637 Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4 0 10.126 17 5 9 5 393 43.6 6.79 2 2 3 3 2 4 6462322.813 751179.4375 3966316.453 2131471.391 2 1 3 3 Acetyl [N-Term] cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00870, Pf07710, Pf08563" 7157 ENSG00000141510.16 TP53 17 TP53 Regulates Transcription of Caspase Activators and Caspases; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Ovarian tumor domain proteases; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Factors involved in megakaryocyte development and platelet production; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Regulation of TP53 Expression; Regulation of TP53 Activity through Phosphorylation; Transcriptional activation of cell cycle inhibitor p21 ; Pre-NOTCH Transcription and Translation; The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M DNA damage checkpoint; Ub-specific processing proteases; PI5P Regulates TP53 Acetylation; Regulation of TP53 Activity through Association with Co-factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Methylation; Activation of NOXA and translocation to mitochondria; Association of TriC/CCT with target proteins during biosynthesis; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Interleukin-4 and 13 signaling; Formation of Senescence-Associated Heterochromatin Foci (SAHF); TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Oxidative Stress Induced Senescence; RUNX3 regulates CDKN1A transcription Viral carcinogenesis; Hepatitis B; Central carbon metabolism in cancer; Pancreatic cancer; MicroRNAs in cancer; Chronic myeloid leukemia; Epstein-Barr virus infection; Neurotrophin signaling pathway; Huntington's disease; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; Glioma; Melanoma; HTLV-I infection; Apoptosis; Wnt signaling pathway; Proteoglycans in cancer; Transcriptional misregulation in cancer; p53 signaling pathway; Sphingolipid signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Herpes simplex infection; Amyotrophic lateral sclerosis (ALS); Thyroid cancer; Hepatitis C; Cell cycle; Endocrine resistance; Basal cell carcinoma; Longevity regulating pathway; PI3K-Akt signaling pathway; Platinum drug resistance 0 High Q9UGR2 Zinc finger CCCH domain-containing protein 7B OS=Homo sapiens OX=9606 GN=ZC3H7B PE=1 SV=2 0 41.931 11 8 9 5 977 109.8 7.25 8 9 115527.375 9189036.75 293507.75 117518.3516 1 5 1 1 0 High Q13084 "39S ribosomal protein L28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" 0 39.103 40 7 9 7 256 30.1 8.29 6 1 8 1 8258231.625 16292520.47 721328.5938 483079.125 2 7 2 1 cell organization and biogenesis;metabolic process cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00830 10573 ENSG00000086504.15 MRPL28 16 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P57088 Transmembrane protein 33 OS=Homo sapiens OX=9606 GN=TMEM33 PE=1 SV=2 0 14.118 19 5 9 5 247 28 9.7 1 5 1 8 568759.1875 1527759799 3292085.438 9694075.875 1 2 4 5 cell organization and biogenesis;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;nucleus protein binding;structural molecule activity Pf03661 55161 ENSG00000109133.12 TMEM33 4 0 High P78371 T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4 0 17.087 12 5 9 5 535 57.5 6.46 1 3 4 1 4 4 987491 3458878.063 2125849.234 1 3 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;extracellular;organelle lumen nucleotide binding;protein binding Pf00118 10576 ENSG00000166226.12 CCT2 12 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC 0 High Q96A33 Coiled-coil domain-containing protein 47 OS=Homo sapiens OX=9606 GN=CCDC47 PE=1 SV=1 0 32.069 18 6 9 6 483 55.8 4.87 4 1 4 4 1 4 678755.875 7248347.938 1252379.5 2868277.25 1 4 2 4 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane metal ion binding;protein binding;RNA binding Pf07946 57003 ENSG00000108588.13 CCDC47 17 0 High Q08554 Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2 0 15.2 6 4 9 4 894 99.9 5.43 3 2 2 5 2 2 2371494.156 39881362 3139669.063 3354336.375 2 1 2 3 cell death;transport cytoskeleton;membrane metal ion binding "Pf00028, Pf01049, Pf08758" 1823 ENSG00000134765.9 DSC1 18 Formation of the cornified envelope; Neutrophil degranulation 0 High O75340 Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1 0 9.097 18 4 9 4 191 21.9 5.4 3 1 2 4 2 3 173176.2813 10695228.25 6711869.25 3303078.844 1 3 3 4 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00036, Pf13405, Pf13499, Pf13833" 10016 ENSG00000249915.7 PDCD6 5 0 High Q12873 Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3 0 28.472 6 9 9 7 2000 226.5 7.3 9 9 169122.7969 19292470.5 1 8 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074, Pf13831" 1107 ENSG00000170004.16 CHD3 17 SUMOylation of chromatin organization proteins; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation 2 High Q9NRW3 DNA dC->dU-editing enzyme APOBEC-3C OS=Homo sapiens OX=9606 GN=APOBEC3C PE=1 SV=2 0 31.628 35 5 9 5 190 22.8 7.59 5 9 244762.4844 27844958.75 1270085 721912.1768 1 4 1 3 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf05240, Pf08210" 27350 ENSG00000244509.3 APOBEC3C 22 Formation of the Editosome 0 High P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4 0 27.672 15 7 9 7 589 65.3 5.11 3 2 4 3 2 4 7353168.875 9719332.438 4635352.352 3 5 6 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;enzyme regulator activity;protein binding "Pf02985, Pf13513, Pf13646" 5518 ENSG00000105568.17 PPP2R1A 19 "Glycolysis; Regulation of PLK1 Activity at G2/M Transition; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; AURKA Activation by TPX2; S33 mutants of beta-catenin aren't phosphorylated; Anchoring of the basal body to the plasma membrane; S45 mutants of beta-catenin aren't phosphorylated; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of mitotic centrosome proteins and complexes; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Recruitment of NuMA to mitotic centrosomes; Initiation of Nuclear Envelope Reformation; Loss of Nlp from mitotic centrosomes; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; Spry regulation of FGF signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex" Dopaminergic synapse; Chagas disease (American trypanosomiasis); TGF-beta signaling pathway; Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; Long-term depression; mRNA surveillance pathway; Oocyte meiosis; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway 0 High Q9BSD7 Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1 0 18.153 33 5 9 5 190 20.7 9.54 2 1 3 2 2 5 1800930.625 2389153.438 5721673.75 1 2 2 metabolic process;response to stimulus membrane catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01583, Pf03029, Pf03266, Pf05496, Pf07726, Pf07728, Pf13173, Pf13191, Pf13207, Pf13238" 84284 ENSG00000135778.11 NTPCR 1 Purine metabolism; Thiamine metabolism; Metabolic pathways 0 High Q92878 DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1 0 13.546 5 7 9 7 1312 153.8 6.89 1 5 3 1 5 3 917494.8125 3013641.375 2509549.906 1017550.875 2 2 4 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf02463, Pf04423, Pf13304, Pf13476, Pf13514, Pf13555, Pf13558" 10111 ENSG00000113522.13 RAD50 5 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Non-homologous end-joining 0 High Q15459 Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1 0 32.849 13 7 9 7 793 88.8 5.22 7 1 8 1 193322857.7 12777964.75 1037212.406 770587.125 2 5 2 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00240, Pf01805, Pf12230, Pf14560" 10291 ENSG00000099995.18 SF3A1 22 mRNA Splicing - Major Pathway Spliceosome 0 High Q969S3 Zinc finger protein 622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1 0 53.615 21 6 9 6 477 54.2 6.15 6 9 23482329.25 463114.25 4 1 regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;nucleus metal ion binding;protein binding;RNA binding "Pf12171, Pf12756, Pf12874" 90441 ENSG00000173545.4 ZNF622 5 0 High P58317 Zinc finger protein 121 OS=Homo sapiens OX=9606 GN=ZNF121 PE=3 SV=2 0 25.282 15 6 9 4 390 44.7 8.05 6 9 241446.1563 23114884.13 86886.16406 638484.125 1 6 1 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 7675 ENSG00000197961.11 ZNF121 19 2 High Q9UJS0 Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens OX=9606 GN=SLC25A13 PE=1 SV=2 0 20.162 14 7 9 7 675 74.1 8.62 1 2 6 1 2 6 3085731.5 6247655.313 5841267.781 2 4 6 metabolic process;response to stimulus;transport membrane;mitochondrion metal ion binding;transporter activity "Pf00153, Pf13499" 10165 ENSG00000004864.13 SLC25A13 7 Gluconeogenesis; Mitochondrial protein import; Metabolism of proteins 0 High Q8NCD3 Holliday junction recognition protein OS=Homo sapiens OX=9606 GN=HJURP PE=1 SV=2 0 36.783 15 8 9 8 748 83.5 9.31 8 9 2712097.148 27815241 3541274.5 1142828.616 3 9 2 4 cell organization and biogenesis;regulation of biological process chromosome;cytosol;mitochondrion;nucleus DNA binding;protein binding "Pf10384, Pf12346, Pf12347" 55355 ENSG00000123485.11 HJURP 2 Deposition of new CENPA-containing nucleosomes at the centromere 0 High P23528 Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3 0 20.42 30 4 9 4 166 18.5 8.09 4 1 2 6 1 2 1194003.234 25881176.13 4678549.5 3841170.313 1 4 2 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding Pf00241 1072 ENSG00000172757.12 CFL1 11 Platelet degranulation ; Sema3A PAK dependent Axon repulsion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Interleukin-12 family signaling Pertussis; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Axon guidance 0 High P11182 "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=3" 0 11.045 10 5 9 5 482 53.5 8.51 5 9 4297329.75 2140920 4 1 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 1629 DBT 1 Branched-chain amino acid catabolism; Glyoxylate metabolism and glycine degradation "Propanoate metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation" 0 High O95831 "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" 0 13.973 12 5 9 5 613 66.9 8.95 2 2 3 3 2 4 3168610.25 5303138.125 3095867.313 2 2 2 cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00070, Pf07992, Pf14721, Pf14962" 9131 ENSG00000156709.13 AIFM1 X Apoptosis 0 High Q92615 La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3 0 16.522 8 6 9 4 738 80.5 6.92 6 9 13677038.5 3017793 4 1 regulation of biological process cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding "Pf05383, Pf14259" 23185 ENSG00000107929.14 LARP4B 10 0 High P50579 Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1 0 56.537 28 6 9 6 478 52.9 5.82 6 9 11090864.38 246434.7334 2012930.035 5 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;metal ion binding;RNA binding Pf00557 10988 ENSG00000111142.13 METAP2 12 "Signaling by GPCR; Inactivation, recovery and regulation of the phototransduction cascade" 0 High Q96L73 "Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1" 0 42.57 5 9 9 9 2696 296.5 8.03 9 9 9521504.875 1486984.625 8594289.5 5 1 2 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00628, Pf00855, Pf00856" 64324 ENSG00000165671.19 NSD1 5 PKMTs methylate histone lysines Lysine degradation 0 High Q8WVS4 WD repeat-containing protein 60 OS=Homo sapiens OX=9606 GN=WDR60 PE=1 SV=3 0 47.98 11 7 9 7 1066 122.5 7.31 7 9 1759081.75 16231871.75 827068 434241.1719 1 5 1 2 cell organization and biogenesis;cellular component movement;transport catalytic activity;motor activity;protein binding 55112 ENSG00000126870.15 WDR60 7 Intraflagellar transport 0 High Q15633 RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3 0 34.883 27 6 9 6 366 39 6.54 6 9 518662885.3 708894.5625 934337.2344 6 1 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00035, Pf14709" 6895 ENSG00000139546.10 TARBP2 12 MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis 0 High Q86YZ3 Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2 0 25.725 9 7 9 7 2850 282.2 10.04 2 2 3 2 3 4 3563353.75 1275514.595 5066542.375 4587288 2 2 3 5 cell organization and biogenesis;development;transport cytoplasm;cytoskeleton;extracellular;nucleus;organelle lumen metal ion binding 388697 ENSG00000197915.5 HRNR 1 Neutrophil degranulation 0 High Q9UMY1 Nucleolar protein 7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2 0 19.577 18 6 9 6 257 29.4 9.67 6 9 33731281.94 316680.8125 10977.25684 6 1 1 mitochondrion;nucleus RNA binding Pf08157 51406 ENSG00000225921.6 NOL7 6 0 High Q02978 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Homo sapiens OX=9606 GN=SLC25A11 PE=1 SV=3 0 14.877 14 4 9 4 314 34 9.91 1 1 4 1 1 7 28907292.5 1833768.563 7094773.5 2 2 3 Met-loss+Acetyl [N-Term] metabolic process;transport membrane;mitochondrion;nucleus RNA binding;transporter activity Pf00153 8402 ENSG00000108528.13 SLC25A11 17 Gluconeogenesis 0 High Q99661 Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2 0 26.718 15 8 9 6 725 81.3 7.83 8 9 14950057.63 4 cell division;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;DNA binding;motor activity;nucleotide binding;protein binding Pf00225 11004 ENSG00000142945.12 KIF2C 1 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation 0 High Q9NV96 Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1 0 15.598 18 5 9 5 361 40.7 8.59 2 5 3 6 227807.6719 25683203.03 5123145.25 4386615.234 1 2 3 4 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding;transporter activity Pf03381 55754 ENSG00000112697.15 TMEM30A 6 Neutrophil degranulation 0 High Q99615 DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2 0 21.121 17 8 9 8 494 56.4 6.96 4 5 4 5 1907845.75 2501686.563 10026474.38 4309265.188 1 3 5 6 metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus enzyme regulator activity;protein binding "Pf00226, Pf00515, Pf07719, Pf13414, Pf13424, Pf13431, Pf13432" 7266 ENSG00000168259.14 DNAJC7 17 Regulation of HSF1-mediated heat shock response 0 High Q9Y5B9 FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1 0 12.869 7 5 9 5 1047 119.8 5.66 3 4 1 4 4 1 1734908.625 9081387.625 6464716.313 3584042.531 2 3 4 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus protein binding;RNA binding "Pf00557, Pf08512, Pf08644, Pf14826" 11198 ENSG00000092201.9 SUPT16H 14 HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat 0 High Q13547 Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1 0 23.834 12 5 9 3 482 55.1 5.48 5 1 8 1 1332896.875 18971323.25 2798312 5587881.313 1 5 2 2 cell differentiation;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf00850 3065 ENSG00000116478.11 HDAC1 1 NOTCH1 Intracellular Domain Regulates Transcription; NoRC negatively regulates rRNA expression; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Factors involved in megakaryocyte development and platelet production; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Activation of E2F1 target genes at G1/S; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Transcription of E2F targets under negative control by DREAM complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of TP53 Activity through Acetylation; Repression of WNT target genes; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; SUMOylation of chromatin organization proteins; Deactivation of the beta-catenin transactivating complex; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; p75NTR negatively regulates cell cycle via SC1; Signalling by NGF; RNA Polymerase I Transcription Initiation Viral carcinogenesis; Longevity regulating pathway - multiple species; MicroRNAs in cancer; Amphetamine addiction; Chronic myeloid leukemia; Epstein-Barr virus infection; Huntington's disease; Pathways in cancer; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer; Notch signaling pathway; Alcoholism; Cell cycle 2 High Q9H7H0 "Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens OX=9606 GN=METTL17 PE=1 SV=1" 0 13.022 13 5 9 5 456 50.7 9.33 5 9 15163620.99 15457640.56 185875.3594 2 5 1 metabolic process mitochondrion;ribosome catalytic activity;metal ion binding;protein binding "Pf08241, Pf08242, Pf09243, Pf12847, Pf13847" 64745 ENSG00000165792.17 METTL17 14 0 High P23284 Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2 0 14.651 28 6 9 6 216 23.7 9.41 6 9 3319062.688 871422.6875 6610803.813 2 2 6 metabolic process;regulation of biological process endoplasmic reticulum;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00160 5479 ENSG00000166794.4 PPIB 15 Collagen biosynthesis and modifying enzymes 0 High Q15776 Zinc finger protein with KRAB and SCAN domains 8 OS=Homo sapiens OX=9606 GN=ZKSCAN8 PE=1 SV=2 0 32.893 16 8 9 7 578 65.8 7.39 8 9 160799 19531274.13 9960614.516 10370689.19 1 6 2 3 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf02023, Pf13465, Pf13912" 7745 ENSG00000198315.10 ZKSCAN8; ZNF192 6 Generic Transcription Pathway 0 High Q9Y388 "RNA-binding motif protein, X-linked 2 OS=Homo sapiens OX=9606 GN=RBMX2 PE=1 SV=2" 0 23.734 20 6 9 6 322 37.3 9.83 6 9 4068955.75 33736478.5 459158.7188 1 5 1 metabolic process;transport spliceosomal complex catalytic activity;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 51634 ENSG00000134597.15 RBMX2 X 0 High Q9Y5L4 Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1 0 29.734 68 6 9 6 95 10.5 8.18 6 9 53778217.75 323309.2813 280885.1829 5 1 2 Acetyl [N-Term] cell organization and biogenesis;transport membrane;mitochondrion metal ion binding;transporter activity Pf02953 26517 ENSG00000099800.7 TIMM13 19 Mitochondrial protein import; Metabolism of proteins 0 High Q9NY61 Protein AATF OS=Homo sapiens OX=9606 GN=AATF PE=1 SV=1 0 40.413 24 7 9 7 560 63.1 4.94 7 9 545077.0156 22352495 16299.43164 2 6 1 Met-loss+Acetyl [N-Term] cell division;regulation of biological process;response to stimulus cytoplasm;Golgi;nucleus protein binding;RNA binding "Pf08164, Pf13339" 26574 ENSG00000276072.2; ENSG00000275700.4 AATF 17; CHR_HSCHR17_7_CTG4 NRAGE signals death through JNK; Signalling by NGF 0 High P62937 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2 0 16.146 24 5 9 5 165 18 7.81 3 4 2 3 4 2 8383247.789 6401390.125 5273686.313 2880749.531 3 4 4 3 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00160 5478 ENSG00000196262.13 PPIA 7 Budding and maturation of HIV virion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Minus-strand DNA synthesis; Binding and entry of HIV virion; Basigin interactions; APOBEC3G mediated resistance to HIV-1 infection; Uncoating of the HIV Virion; Calcineurin activates NFAT; Platelet degranulation ; Plus-strand DNA synthesis; Integration of provirus; Neutrophil degranulation; Assembly Of The HIV Virion; Interleukin-12 family signaling 0 High Q8IYH5 ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1 0 13.067 8 5 9 5 903 102 5.69 1 5 1 8 753679.375 9925045.375 3207301.219 1 4 4 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00249, Pf00569" 26009 ENSG00000036549.12 ZZZ3 1 HATs acetylate histones 0 High Q8NFZ0 F-box DNA helicase 1 OS=Homo sapiens OX=9606 GN=FBH1 PE=1 SV=2 0 12.418 5 6 9 6 1043 117.6 8.25 4 4 5 4 1340375.25 8760117.438 8309412.5 5364080.75 1 4 5 6 cell death;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00580, Pf00646, Pf12937, Pf13086, Pf13245, Pf13361, Pf13538" 84893 ENSG00000134452.19 FBXO18 10 0 High Q13308 Inactive tyrosine-protein kinase 7 OS=Homo sapiens OX=9606 GN=PTK7 PE=1 SV=2 0 24.204 8 7 9 7 1070 118.3 7.09 1 7 1 8 1169403.484 10116562.81 1609809.813 5511479.875 2 3 2 7 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding "Pf00047, Pf00069, Pf07679, Pf07714, Pf13895, Pf13927, Pf14575" 5754 ENSG00000112655.15 PTK7 6 0 High Q6DD87 Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4 0 32.933 23 6 8 6 382 40.4 7.96 6 8 14597519.75 1471440.031 508692.6406 4 2 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 126208 ENSG00000142409.5 ZNF787 19 0 High P48651 Phosphatidylserine synthase 1 OS=Homo sapiens OX=9606 GN=PTDSS1 PE=1 SV=1 0 18.843 9 4 8 4 473 55.5 8.43 3 2 6 2 15277746.09 412246.2725 4 3 Met-loss+Acetyl [N-Term] metabolic process endoplasmic reticulum;membrane catalytic activity Pf03034 9791 ENSG00000156471.12 PTDSS1 8 Synthesis of PS Glycerophospholipid metabolism; Metabolic pathways 0 High Q9BPX6 "Calcium uptake protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MICU1 PE=1 SV=1" 0 20.778 15 8 8 8 476 54.3 8.41 8 8 335665.625 18361537 128399.1406 113767.9141 2 7 1 1 cell organization and biogenesis;cellular homeostasis;defense response;response to stimulus;transport membrane;mitochondrion metal ion binding;protein binding Pf13202 10367 ENSG00000107745.17 MICU1 10 Processing of SMDT1 0 High Q14232 Translation initiation factor eIF-2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1 0 32.204 30 7 8 7 305 33.7 7.33 7 8 2065573.875 15333191.63 512939.4375 1301400.676 1 6 1 4 metabolic process;response to stimulus cytoplasm;cytosol;membrane protein binding;RNA binding Pf01008 1967 ENSG00000111361.12 EIF2B1 12 Recycling of eIF2:GDP RNA transport 0 High Q9BYG3 MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1 0 35.411 37 7 8 7 293 34.2 9.88 7 8 980449.125 23503510.63 2 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf12196, Pf13893, Pf14259" 84365 ENSG00000155438.11 MKI67IP; NIFK 2 0 High P28799 Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2 0 30.611 11 4 8 4 593 63.5 6.83 4 1 7 1 10174470.38 1278255.625 3 1 regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;extracellular;organelle lumen;vacuole protein binding;RNA binding Pf00396 2896 ENSG00000030582.17 GRN 17 Neutrophil degranulation 0 High Q14011 Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1 0 30.089 41 6 8 5 172 18.6 9.51 6 8 552979.4375 37116643.5 684995.6055 16304.32324 1 5 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding;RNA binding;translation regulator activity "Pf00076, Pf13893, Pf14259" 1153 ENSG00000099622.13 CIRBP 19 0 High Q9NS87 Kinesin-like protein KIF15 OS=Homo sapiens OX=9606 GN=KIF15 PE=1 SV=1 0 11.145 4 4 8 4 1388 160.1 6 3 1 2 1 4 1 2 1 3837775.703 160065.1094 497582.6433 237156.0796 3 1 2 2 cell proliferation;cellular component movement;metabolic process;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;DNA binding;motor activity;nucleotide binding;protein binding;transporter activity "Pf00225, Pf01496, Pf02463, Pf04111, Pf05622, Pf08317, Pf12128, Pf12711, Pf13166, Pf13514, Pf15619" 56992 ENSG00000280610.2; ENSG00000163808.16 KIF15 3; CHR_HG2066_PATCH COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation 0 High Q9HAN9 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Homo sapiens OX=9606 GN=NMNAT1 PE=1 SV=1 0 29.001 25 6 8 6 279 31.9 8.87 6 1 7 1 180305.8281 27884045.5 892500.3647 840519.2617 1 5 3 2 metabolic process;response to stimulus nucleus catalytic activity;nucleotide binding;protein binding Pf01467 64802 ENSG00000173614.13 NMNAT1 1 Nicotinate metabolism Nicotinate and nicotinamide metabolism; Metabolic pathways 0 High P78347 General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2 0 16.211 7 7 8 7 998 112.3 6.39 3 3 2 3 3 2 8938041.281 6099274.5 3095277.75 1855805.656 3 4 3 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus DNA binding;protein binding Pf02946 2969 ENSG00000263001.5 GTF2I 7 Basal transcription factors; cGMP-PKG signaling pathway; Herpes simplex infection 0 High P0DP25 Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1 0 29.551 37 3 8 3 149 16.8 4.22 1 2 3 1 1 3 3 1 674652.75 10901478.56 12079881.63 4139713.75 1 2 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane catalytic activity;enzyme regulator activity;metal ion binding;protein binding;transporter activity "Pf00036, Pf08726, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833, Pf14658" 808; 805; 801 ENSG00000160014.16; ENSG00000143933.16; ENSG00000198668.10 CALM3; CALM2; CALM1 19; 2; 14 "Smooth Muscle Contraction; Uptake and function of anthrax toxins; Stimuli-sensing channels; Translocation of GLUT4 to the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Reduction of cytosolic Ca++ levels; CREB phosphorylation through the activation of CaMKII; Ion homeostasis; Ca2+ pathway; Phase 0 - rapid depolarisation; Calcineurin activates NFAT; Platelet degranulation ; eNOS activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; CaMK IV-mediated phosphorylation of CREB; Activation of CaMK IV; RAF/MAP kinase cascade; Inactivation, recovery and regulation of the phototransduction cascade; FCERI mediated Ca+2 mobilization; Cam-PDE 1 activation; Glycogen breakdown (glycogenolysis); Signaling by GPCR; Sodium/Calcium exchangers; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Interleukin-20 family signaling; RHO GTPases activate PAKs; Protein methylation; DARPP-32 events; RHO GTPases activate IQGAPs; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Ras activation uopn Ca2+ infux through NMDA receptor; PKA activation; Ion transport by P-type ATPases; Transcriptional activation of mitochondrial biogenesis; Activation of Ca-permeable Kainate Receptor; CLEC7A (Dectin-1) induces NFAT activation" Dopaminergic synapse; Phototransduction; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Renin secretion; Neurotrophin signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; Long-term potentiation; Glioma; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Pertussis; Melanogenesis; Alzheimer's disease; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; Alcoholism; Ras signaling pathway; GnRH signaling pathway; cAMP signaling pathway; Estrogen signaling pathway; Calcium signaling pathway 0 High Q8TEQ6 Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3 0 26.902 6 6 8 6 1508 168.5 6.62 2 5 1 2 5 1 389171.3594 5789528.125 5144920.438 4836077.5 3 4 3 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf00400 25929 ENSG00000082516.8 GEMIN5 5 snRNP Assembly RNA transport 0 High P23588 Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2 0 37.442 20 7 8 7 611 69.1 5.73 7 8 45619239.69 835575.875 615664.2188 5 2 3 cell organization and biogenesis;metabolic process;regulation of biological process cytosol catalytic activity;protein binding;RNA binding "Pf00076, Pf14259" 1975 ENSG00000063046.17 EIF4B 12 mTORC1-mediated signalling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition Proteoglycans in cancer; mTOR signaling pathway; RNA transport; PI3K-Akt signaling pathway 0 High O95218 Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2 0 8.205 10 3 8 3 330 37.4 10.01 1 2 2 2 3 3 809599.1465 816719.75 6689172.125 3133636.938 1 1 3 3 metabolic process;regulation of biological process nucleus metal ion binding;protein binding;RNA binding Pf00641 9406 ENSG00000132485.13 ZRANB2 1 0 High P61009 Signal peptidase complex subunit 3 OS=Homo sapiens OX=9606 GN=SPCS3 PE=1 SV=1 0 13.672 19 4 8 4 180 20.3 8.62 4 8 316597.625 604446.4375 32599530.06 1 1 4 metabolic process;transport endoplasmic reticulum;membrane catalytic activity Pf04573 60559 ENSG00000129128.12 SPCS3 4 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)" Protein export 0 High Q8N5P1 Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2 0 38.129 29 5 8 5 291 33.6 8.28 5 8 18264048.5 4 cell death;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding;protein binding;RNA binding 84524 ENSG00000144161.12 ZC3H8 2 RNA polymerase II transcribes snRNA genes 0 High P29692 Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5 0 8.101 8 2 8 2 281 31.1 5.01 2 1 2 1 3 1 3 1 1303549.25 4185780.25 1933496.5 2 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus DNA binding;protein binding;RNA binding;signal transducer activity "Pf00736, Pf10587" 1936 ENSG00000104529.17; ENSG00000273594.4 EEF1D 8; CHR_HSCHR8_3_CTG7 Eukaryotic Translation Elongation Herpes simplex infection 0 High Q8N0V3 "Putative ribosome-binding factor A, mitochondrial OS=Homo sapiens OX=9606 GN=RBFA PE=1 SV=3" 0 22.825 21 5 8 4 343 38.3 7.85 1 3 2 1 5 2 415607.4063 4526700.281 2718035.5 5766685.031 1 4 1 2 metabolic process mitochondrion catalytic activity;protein binding "Pf02033, Pf02637" 79863 ENSG00000101546.12 RBFA 18 1 High Q8IZ83 Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2 0 14.403 8 5 8 5 802 85.1 6.79 5 8 3416066.734 25565877 1834.203247 5 2 1 metabolic process membrane catalytic activity "Pf00171, Pf07368" 126133 ENSG00000161618.9 ALDH16A1 19 0 High Q9H8E8 Cysteine-rich protein 2-binding protein OS=Homo sapiens OX=9606 GN=KAT14 PE=1 SV=3 0 18.378 8 6 8 6 782 88.8 6.57 6 1 7 1 1090631.5 6569873.25 974706.5625 1 4 1 cell organization and biogenesis;metabolic process cytoplasm;mitochondrion;nucleus catalytic activity;protein binding "Pf00583, Pf08445, Pf13508, Pf13527, Pf13673" 100303755; 57325 ENSG00000149474.13 PET117; CSRP2BP; KAT14 20 HATs acetylate histones 0 High Q9UPN3 "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" 0 31.82 2 8 8 8 7388 837.8 5.39 8 8 162497.3086 9300049.719 313044 1072800.125 2 6 1 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;Golgi;membrane catalytic activity;metal ion binding;motor activity;protein binding;RNA binding "Pf00036, Pf00307, Pf00435, Pf00681, Pf01576, Pf02187, Pf10498, Pf11971, Pf13499, Pf13514, Pf13833" 23499 ENSG00000127603.23 MACF1 1 Signaling by BRAF and RAF fusions 0 High Q9UHI6 Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2 0 16.379 10 7 8 7 824 92.2 6.95 4 2 1 1 4 2 1 1 1611928.26 2749388.313 2501536.781 1896611.844 5 2 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00270, Pf00271" 11218 ENSG00000064703.11 DDX20 1 snRNP Assembly RNA transport 0 High Q09028 Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3 0 29.257 16 5 8 3 425 47.6 4.89 1 5 1 7 655435.2813 27221563.25 575782.625 988028.5 2 5 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf00400, Pf12265" 5928 ENSG00000162521.18 RBBP4 1 Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cyclin A:Cdk2-associated events at S phase entry; Deposition of new CENPA-containing nucleosomes at the centromere; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Cyclin E associated events during G1/S transition ; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; Activation of E2F1 target genes at G1/S; HDACs deacetylate histones; Transcription of E2F targets under negative control by DREAM complex; Oxidative Stress Induced Senescence; RNA Polymerase I Transcription Initiation 2 High Q14331 Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1 0 26.544 28 6 8 6 258 29.2 9.01 6 8 85982.47656 29772859.75 602980.8125 2032378.5 1 5 1 1 metabolic process cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf06229, Pf06268" 2483 ENSG00000283153.1; ENSG00000283630.1; ENSG00000109536.11; ENSG00000275145.3 FRG1 4; CHR_HG2023_PATCH; CHR_HSCHR4_11_CTG12; CHR_HSCHR4_6_CTG12 0 High Q86U42 Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3 0 30.983 22 4 8 4 306 32.7 5.06 4 8 90337.01563 23042596 8338.546875 1 4 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 8106 ENSG00000100836.10 PABPN1 14 Inhibition of Host mRNA Processing and RNA Silencing; mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs mRNA surveillance pathway; Influenza A 0 High Q9UGY1 Nucleolar protein 12 OS=Homo sapiens OX=9606 GN=NOL12 PE=1 SV=1 0 27.089 27 4 8 4 213 24.6 10.23 4 8 35583947 413743.2813 4 1 nucleus protein binding;RNA binding Pf09805 79159 ENSG00000273899.4 NOL12 22 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q3ZCQ8 Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2 0 15.332 20 5 8 5 353 39.6 8.37 3 1 3 4 1 3 192967.4375 25434017.13 628029.459 1192227.316 1 3 2 4 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding Pf03031 92609 ENSG00000105197.10 TIMM50 19 Mitochondrial protein import; Metabolism of proteins 0 High P34897 "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" 0 21.75 17 7 8 7 504 56 8.53 3 5 3 5 2242182.281 147775479.6 6315268.313 4564602.219 2 3 6 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf00464 6472 ENSG00000182199.10 SHMT2 12 Metabolism of folate and pterines "Carbon metabolism; Glycine, serine and threonine metabolism; Antifolate resistance; Biosynthesis of amino acids; One carbon pool by folate; Metabolic pathways; Glyoxylate and dicarboxylate metabolism" 0 High Q9BYC9 "39S ribosomal protein L20, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" 0 16.272 27 4 8 4 149 17.4 10.86 4 8 318603.9375 12348278.5 496553.7734 108882.6719 1 3 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00453 55052 ENSG00000242485.5 MRPL20 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P39060 Collagen alpha-1(XVIII) chain OS=Homo sapiens OX=9606 GN=COL18A1 PE=1 SV=5 0 12.046 4 5 8 5 1754 178.1 6.01 1 4 2 1 4 3 565959.9434 2618271.563 4954085.063 8502734.531 4 2 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus extracellular;organelle lumen metal ion binding;protein binding;structural molecule activity "Pf01391, Pf01392, Pf06121, Pf06482, Pf13385" 80781 ENSG00000182871.14 COL18A1 21 Collagen degradation; Activation of Matrix Metalloproteinases; Integrin cell surface interactions; Laminin interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization Protein digestion and absorption 0 High P06756 Integrin alpha-V OS=Homo sapiens OX=9606 GN=ITGAV PE=1 SV=2 0 20.868 8 8 8 8 1048 116 5.68 8 8 100401.2188 4818663.188 1801563.25 5961821.875 1 2 3 7 cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytosol;membrane metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf01839, Pf08441, Pf13517" 3685 ENSG00000138448.11 ITGAV 2 Integrin cell surface interactions; Signal transduction by L1; PECAM1 interactions; Cross-presentation of particulate exogenous antigens (phagosomes); VEGFA-VEGFR2 Pathway; Molecules associated with elastic fibres; Syndecan interactions; ECM proteoglycans; Laminin interactions; Neutrophil degranulation Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Cell adhesion molecules (CAMs); Pathways in cancer; Thyroid hormone signaling pathway; Phagosome; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Hypertrophic cardiomyopathy (HCM) 0 High Q08380 Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1 0 9.111 6 3 8 3 585 65.3 5.27 1 1 3 2 1 1 4 2 633161.75 8561985.5 19460774.56 6765264.5 1 2 3 2 defense response;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen protein binding;receptor activity "Pf00530, Pf07707" 3959 ENSG00000108679.12 LGALS3BP 17 Platelet degranulation 0 High Q99832 T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2 0 9.202 10 5 8 5 543 59.3 7.65 1 1 4 2 1 1 4 2 238627.5 711841.1406 3631492.938 2161058.313 1 2 4 4 metabolic process;regulation of biological process;transport cytoplasm;cytosol;mitochondrion nucleotide binding;protein binding Pf00118 10574 ENSG00000135624.15 CCT7 2 Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High P21741 Midkine OS=Homo sapiens OX=9606 GN=MDK PE=1 SV=1 0 33.594 44 6 8 6 143 15.6 9.79 6 8 27364204.13 402337.9375 460297.1094 6 1 2 cell differentiation;cellular component movement;defense response;development;regulation of biological process;response to stimulus cytoplasm;extracellular protein binding "Pf01091, Pf05196" 4192 ENSG00000110492.15 MDK 11 NOTCH2 Activation and Transmission of Signal to the Nucleus 0 High Q8NFC6 Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2 0 20.334 3 7 8 7 3051 330.3 5.08 6 2 6 2 2437479.82 606916.5625 5411325.125 3680757.469 4 1 7 7 metabolic process;response to stimulus chromosome Pf05205 259282 ENSG00000038219.12 BOD1L1 4 0 High P19388 "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" 0 17.598 27 5 8 5 210 24.5 5.95 1 5 1 1 5 2 897002.1875 26438940 1672677.375 749949.8125 2 5 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf01191, Pf03871" 5434 ENSG00000099817.11 POLR2E 19 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q04724 Transducin-like enhancer protein 1 OS=Homo sapiens OX=9606 GN=TLE1 PE=1 SV=2 0 8.698 6 4 8 2 770 83.1 7.24 4 8 2839325.313 2229672.25 7066222.188 4 1 2 development;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding "Pf00400, Pf03920" 7088 ENSG00000196781.14 TLE1 9 NOTCH1 Intracellular Domain Regulates Transcription; Repression of WNT target genes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex 2 High Q14562 ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1 0 31.115 9 7 8 6 1220 139.2 8.32 7 8 9992386.531 826419.9844 6 2 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00271, Pf00575, Pf04408, Pf07717" 1659 ENSG00000067596.10 DHX8 17 Spliceosome 0 High O14744 Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4 0 23.191 12 6 8 6 637 72.6 6.29 6 1 1 6 1 1 438603.8125 15497507.88 3827789.906 623463.0938 3 5 1 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf02475, Pf05185" 10419 ENSG00000100462.15 PRMT5 14 snRNP Assembly; Regulation of TP53 Activity through Methylation; RMTs methylate histone arginines RNA transport 0 High P62306 Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1 0 24.214 41 2 8 2 86 9.7 4.67 1 2 1 1 6 1 621226.625 49050711.75 602999.5625 815026.0005 1 3 1 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6636 ENSG00000139343.10 SNRPF 12 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome 0 High Q96CS3 FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2 0 12.446 17 4 8 4 445 52.6 5.62 3 4 4 4 13045327 2657270.531 2339370.281 1 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;organelle lumen enzyme regulator activity;protein binding "Pf00789, Pf14555" 23197 ENSG00000113194.12 FAF2 5 Neutrophil degranulation 0 High Q9NTJ3 Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2 0 20.352 6 7 8 7 1288 147.1 6.79 3 3 2 3 3 2 43423.80859 28367628.09 2391812.75 1783409.344 1 4 3 4 cell division;cell organization and biogenesis;metabolic process chromosome;cytoplasm;cytosol;nucleus nucleotide binding;protein binding "Pf02463, Pf04012, Pf04111, Pf04156, Pf06470, Pf12128, Pf13166, Pf13304, Pf13476, Pf13555" 10051 ENSG00000113810.15 SMC4 3 Condensation of Prometaphase Chromosomes; Condensation of Prophase Chromosomes 0 High Q9C005 Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1 0 9.397 27 3 8 3 99 11.2 4.88 1 3 2 1 5 2 4830176 5893103.375 3819826.797 2 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport Golgi;nucleus catalytic activity;protein binding Pf05186 84661 ENSG00000162961.13 DPY30 2 PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 0 High Q14980 Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2 0 32.869 5 8 8 8 2115 238.1 5.78 8 8 5785280.313 4 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf04111, Pf07888, Pf12128" 4926 ENSG00000137497.17 NUMA1 11 Mitotic Prophase; Recruitment of NuMA to mitotic centrosomes 0 High Q5T4B2 Inactive glycosyltransferase 25 family member 3 OS=Homo sapiens OX=9606 GN=CERCAM PE=1 SV=1 0 26.402 13 6 8 6 595 67.5 6.06 6 8 103382.6875 279978.5625 8833081.313 1 1 6 cellular component movement endoplasmic reticulum;membrane;organelle lumen Pf01755 51148 ENSG00000167123.18 CERCAM 9 0 High Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3 0 21.229 5 7 8 5 1555 177.1 5.63 7 8 1382196.625 970184.875 2239200.031 1 1 5 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;organelle lumen catalytic activity;protein binding Pf06427 56886 ENSG00000136731.12 UGGT1 2 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High Q92888 Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2 0 18.378 8 7 8 7 912 102.4 5.66 1 7 1 7 509053.5469 1460101.063 1270906.969 5502035.5 2 2 4 7 cell proliferation;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf00621, Pf09128" 9138 ENSG00000076928.17 ARHGEF1 19 G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle Vascular smooth muscle contraction; Pathways in cancer; Proteoglycans in cancer; Regulation of actin cytoskeleton; Platelet activation 0 High Q9P016 Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1 0 16.707 29 6 8 6 225 25.7 9.25 6 8 16290284 225088.2188 2160169.625 6 1 2 nucleus Pf01878 29087 ENSG00000151500.14 THYN1 11 0 High Q9Y5T5 Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1 0 26.346 10 8 8 8 823 93.5 6.93 8 8 696041.8081 22575925.75 2378340.563 2160725.25 3 8 3 3 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;metal ion binding;protein binding "Pf00443, Pf02148, Pf13423" 10600 ENSG00000156256.14 USP16 21 Ub-specific processing proteases 0 High Q14573 "Inositol 1,4,5-trisphosphate receptor type 3 OS=Homo sapiens OX=9606 GN=ITPR3 PE=1 SV=2" 0 14.061 3 7 8 3 2671 303.9 6.48 7 1 7 1 167301.0156 1205438.875 4586258.813 763002.1719 1 1 7 3 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;nucleus metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf00520, Pf01027, Pf01365, Pf02815, Pf03772, Pf08454, Pf08709" 3710 ENSG00000096433.10 ITPR3 6 Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; Ca2+ pathway; DAG and IP3 signaling; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Elevation of cytosolic Ca2+ levels; Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis Dopaminergic synapse; Serotonergic synapse; NOD-like receptor signaling pathway; Vascular smooth muscle contraction; Glutamatergic synapse; cGMP-PKG signaling pathway; Renin secretion; Oxytocin signaling pathway; Circadian entrainment; Long-term potentiation; Insulin secretion; Gap junction; Phosphatidylinositol signaling system; Taste transduction; Glucagon signaling pathway; Thyroid hormone synthesis; Pancreatic secretion; Apoptosis; Proteoglycans in cancer; Alzheimer's disease; Long-term depression; Aldosterone synthesis and secretion; Retrograde endocannabinoid signaling; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Estrogen signaling pathway; Cholinergic synapse; Calcium signaling pathway; Platelet activation 4 High Q7Z333 Probable helicase senataxin OS=Homo sapiens OX=9606 GN=SETX PE=1 SV=4 0 34.097 3 7 8 7 2677 302.7 7.17 7 8 612769.1563 15968849.75 286091.9688 2 6 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00580, Pf13086, Pf13087, Pf13245, Pf13401, Pf13604" 23064 ENSG00000107290.13 SETX 9 0 High Q9Y6X9 ATPase MORC2 OS=Homo sapiens OX=9606 GN=MORC2 PE=1 SV=2 0 24.387 8 7 8 7 1032 117.8 8.38 7 8 231784.4688 9638644.25 1745891.375 735761.9375 1 4 1 1 metabolic process cytoplasm;cytosol;nucleus metal ion binding;protein binding "Pf02518, Pf03938, Pf07496, Pf13589" 22880 ENSG00000133422.12 MORC2 22 Fatty acyl-CoA biosynthesis 0 High Q9H116 GDNF-inducible zinc finger protein 1 OS=Homo sapiens OX=9606 GN=GZF1 PE=1 SV=1 0 26.001 14 6 8 6 711 80.4 7.87 6 8 12025192.22 8190307 6416674.625 7 1 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00651, Pf13465" 64412 ENSG00000125812.15 GZF1 20 0 High Q8WY36 HMG box transcription factor BBX OS=Homo sapiens OX=9606 GN=BBX PE=1 SV=1 0 38.76 13 7 8 7 941 105.1 8.79 7 8 13912703.95 1237795.086 6 3 metabolic process;regulation of biological process cytosol;nucleus DNA binding "Pf00505, Pf09011, Pf09667" 56987 ENSG00000114439.18 BBX 3 0 High O95816 BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1 0 9.567 16 3 7 3 211 23.8 6.7 2 1 2 2 2 3 1333353.406 405359.1563 2164834.938 1515014.063 2 1 2 2 metabolic process;regulation of biological process cytosol enzyme regulator activity;nucleotide binding;protein binding Pf02179 9532 ENSG00000112208.11 BAG2 6 Regulation of HSF1-mediated heat shock response Protein processing in endoplasmic reticulum 0 High Q16576 Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1 0 19.245 17 5 7 3 425 47.8 5.05 5 1 6 1 5372511 1341755.5 441657.9688 2 1 1 cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf00400, Pf12265" 5931 ENSG00000102054.17 RBBP7 X RMTs methylate histone arginines; Regulation of TP53 Activity through Acetylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HATs acetylate histones; Neddylation; Deposition of new CENPA-containing nucleosomes at the centromere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; HDACs deacetylate histones; Oxidative Stress Induced Senescence; RNA Polymerase I Transcription Initiation 0 High O00442 RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1 0 36.332 26 7 7 7 366 39.3 7.85 7 7 312846.5938 21449168.75 100793.5391 19939.0896 1 5 1 2 metabolic process nucleus catalytic activity;nucleotide binding;RNA binding "Pf01137, Pf05189" 8634 ENSG00000137996.12 RTCA 1 0 High P08559 "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" 0 8.208 10 4 7 2 390 43.3 8.06 1 2 4 1 2 4 165273.4531 81293903.34 2021750.375 2160932.609 1 3 2 4 metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf00676 5160 ENSG00000131828.13 PDHA1 X Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways 2 High P82912 "28S ribosomal protein S11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" 0 22.849 28 4 7 4 194 20.6 10.81 4 1 6 1 39447362 1766420.313 628501.5469 4 2 1 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00411 64963 ENSG00000181991.15 MRPS11 15 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q8IZH2 5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1 0 18.645 5 7 7 7 1706 194 7.21 7 7 14837394 5 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf03159 54464 ENSG00000114127.10 XRN1 3 "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; mRNA decay by 5' to 3' exoribonuclease" Ribosome biogenesis in eukaryotes; RNA degradation 0 High Q86V59 Paraneoplastic antigen-like protein 8A OS=Homo sapiens OX=9606 GN=PNMA8A PE=1 SV=2 0 21.856 17 5 7 5 439 48.1 8.97 5 7 6802793 335185.0625 3 1 Pf14893 55228 ENSG00000182013.17 PNMAL1; PNMA8A 19 0 High Q6ZN55 Zinc finger protein 574 OS=Homo sapiens OX=9606 GN=ZNF574 PE=1 SV=2 0 30.758 14 7 7 7 896 98.8 8.07 7 7 1544082.25 10688841.09 2 6 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 64763 ENSG00000105732.12 ZNF574 19 0 High P53680 AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2 0 9.24 19 3 7 3 142 17 6.18 3 1 6 1 163898.9844 25281174.69 1893954.375 1538724.375 1 3 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane protein binding;transporter activity Pf01217 1175 ENSG00000042753.11 AP2S1 19 "Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle 0 High Q9NV31 U3 small nucleolar ribonucleoprotein protein IMP3 OS=Homo sapiens OX=9606 GN=IMP3 PE=1 SV=1 0 27.228 31 5 7 5 184 21.8 9.5 5 7 35212285.5 776216.625 1690464.625 4 1 1 metabolic process;regulation of biological process nucleus protein binding;RNA binding;structural molecule activity Pf01479 55272 ENSG00000177971.8 IMP3 15 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q14974 Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2 0 16.762 6 5 7 5 876 97.1 4.78 1 4 2 1 4 2 264426.6744 4626031.145 3412698.469 3395150.25 2 3 4 5 Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen metal ion binding;protein binding;RNA binding;transporter activity "Pf02985, Pf03810, Pf13513, Pf13646" 3837 ENSG00000108424.9 KPNB1 17 ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Neutrophil degranulation; Regulation of cholesterol biosynthesis by SREBP (SREBF); Transport of Ribonucleoproteins into the Host Nucleus; Activation of DNA fragmentation factor RNA transport 0 High Q7L3S4 Zinc finger protein 771 OS=Homo sapiens OX=9606 GN=ZNF771 PE=1 SV=1 0 23.884 23 5 7 5 317 35.7 8.79 5 7 25702652 948775.375 2396786.125 4 1 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 51333 ENSG00000179965.11 ZNF771 16 Generic Transcription Pathway 0 High P36957 "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" 0 9.199 9 4 7 4 453 48.7 8.95 4 1 1 1 4 1 1 1 5669458.25 2314653.25 1411240 1244443.984 4 2 1 2 metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity "Pf00198, Pf00364" 1743 ENSG00000119689.14 DLST 14 Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Lysine degradation; Metabolic pathways 0 High Q53H12 "Acylglycerol kinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGK PE=1 SV=2" 0 14.8 16 6 7 6 422 47.1 8.09 1 5 1 6 144166540 1958033 2269752.313 4458053.063 2 2 2 5 cell organization and biogenesis;metabolic process;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding Pf00781 55750 ENSG00000006530.15 AGK 7 Signaling by BRAF and RAF fusions; Glycerophospholipid biosynthesis Glycerolipid metabolism; Metabolic pathways 0 High Q14643 "Inositol 1,4,5-trisphosphate receptor type 1 OS=Homo sapiens OX=9606 GN=ITPR1 PE=1 SV=3" 0 15.112 2 6 7 2 2758 313.7 6.04 6 1 6 1 1387913 321712.5625 1 1 cell death;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" 3708 ENSG00000150995.18 ITPR1 3 Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; Ca2+ pathway; cGMP effects; DAG and IP3 signaling; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Elevation of cytosolic Ca2+ levels; Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis Dopaminergic synapse; Serotonergic synapse; NOD-like receptor signaling pathway; Vascular smooth muscle contraction; Glutamatergic synapse; cGMP-PKG signaling pathway; Renin secretion; Huntington's disease; Oxytocin signaling pathway; Circadian entrainment; Long-term potentiation; Gap junction; Phosphatidylinositol signaling system; Glucagon signaling pathway; Thyroid hormone synthesis; Pancreatic secretion; Apoptosis; Proteoglycans in cancer; Alzheimer's disease; Long-term depression; Aldosterone synthesis and secretion; Retrograde endocannabinoid signaling; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Estrogen signaling pathway; Cholinergic synapse; Calcium signaling pathway; Platelet activation 0 High P50897 Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1 0 17.451 21 4 7 4 306 34.2 6.52 1 4 1 6 502977.2656 1605988.438 7520946.813 1 1 4 cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen;vacuole catalytic activity;protein binding Pf02089 5538 ENSG00000131238.16 PPT1 1 Fatty acyl-CoA biosynthesis Lysosome; Fatty acid elongation; Metabolic pathways; Fatty acid metabolism 0 High Q1KMD3 Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1 0 34.261 11 7 7 7 747 85.1 4.91 7 7 1599696.5 13429976.34 75404.625 186155.0156 2 5 1 1 membrane;nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf08433, Pf13671" 221092 ENSG00000214753.2 HNRNPUL2 11 0 High Q8NEJ9 Neuroguidin OS=Homo sapiens OX=9606 GN=NGDN PE=1 SV=1 0 27.897 25 6 7 6 315 35.9 9.57 6 7 13629454.13 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process chromosome;cytoplasm;mitochondrion;nucleus protein binding;RNA binding Pf04000 25983 ENSG00000129460.15 NGDN 14 0 High Q96EL2 "28S ribosomal protein S24, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS24 PE=1 SV=1" 0 41.49 51 7 7 7 167 19 9.38 7 7 967384.375 21119592.88 1 4 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf14955 64951 ENSG00000062582.13 MRPS24 7 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q7RTV0 PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1 0 19.572 55 6 7 6 110 12.4 8.41 6 7 410404.7813 28346481 1 5 metabolic process;regulation of biological process nucleus;spliceosomal complex DNA binding;metal ion binding;RNA binding Pf03660 84844 ENSG00000100410.7 PHF5A 22 mRNA Splicing - Major Pathway Spliceosome 0 High P50750 Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3 0 18.97 17 6 7 5 372 42.8 8.79 1 5 1 1 5 1 385956.2188 8395697.25 10558048.5 1960302.75 1 3 1 1 cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00069, Pf07714" 1025 ENSG00000136807.13 CDK9 9 RNA polymerase II transcribes snRNA genes; Interactions of Tat with host cellular proteins; Tat-mediated HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation Transcriptional misregulation in cancer 1 High Q92979 Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4 0 30.896 27 5 7 5 244 26.7 9.17 5 7 879770.8438 16556338.75 1612623.406 1531644.805 2 5 2 2 metabolic process cytoplasm;nucleus catalytic activity;protein binding;RNA binding Pf03587 10436 ENSG00000126749.14 EMG1 12 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High P06493 Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3 0 10.691 18 4 7 3 297 34.1 8.4 1 2 1 2 1 3 1 2 299896.3125 7483514.82 828678.9375 2106784.938 1 3 1 2 cell death;cell differentiation;cell division;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;receptor activity "Pf00069, Pf01636, Pf07714, Pf14531" 983 ENSG00000170312.15 CDK1 10 "Regulation of PLK1 Activity at G2/M Transition; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Recruitment of NuMA to mitotic centrosomes; Ovarian tumor domain proteases; Loss of Nlp from mitotic centrosomes; Activation of E2F1 target genes at G1/S; MASTL Facilitates Mitotic Progression; Golgi Cisternae Pericentriolar Stack Reorganization; Activation of NIMA Kinases NEK9, NEK6, NEK7; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by RUNX2; Interleukin-20 family signaling; APC/C:Cdc20 mediated degradation of Cyclin B; G2/M DNA replication checkpoint; Condensation of Prometaphase Chromosomes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Regulation of TP53 Degradation; Phosphorylation of Emi1; MAPK3 (ERK1) activation; Recruitment of mitotic centrosome proteins and complexes; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; E2F-enabled inhibition of pre-replication complex formation; Phosphorylation of the APC/C; Depolymerisation of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Resolution of Sister Chromatid Cohesion; Condensation of Prophase Chromosomes; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling" Viral carcinogenesis; Epstein-Barr virus infection; Progesterone-mediated oocyte maturation; Gap junction; p53 signaling pathway; Oocyte meiosis; Herpes simplex infection; Cell cycle 0 High Q13765 Nascent polypeptide-associated complex subunit alpha OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1 0 20.684 20 3 7 3 215 23.4 4.56 3 7 26280109.5 1965555.375 499226.125 3 1 1 metabolic process;regulation of biological process;transport cytoplasm;nucleus DNA binding;protein binding Pf01849 4666 ENSG00000196531.10 NACA 12 0 High Q9NVC6 Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2 0 9.71 7 4 7 4 651 72.8 7.44 1 1 3 1 1 5 1121344.563 792438.3125 1382267.406 2116653.875 2 1 2 3 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity Pf10156 9440 ENSG00000042429.11 MED17 11 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High Q9BTD8 RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1 0 16.721 11 5 7 5 480 50.4 9.63 5 7 37668330.75 11700.3418 5 1 regulation of biological process cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 79171 ENSG00000126254.11 RBM42 19 0 High Q6P6C2 RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2 0 19.72 16 6 7 6 394 44.2 9.09 6 7 2410212.156 20162785.38 6122479.031 7751012.031 4 6 2 2 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;response to stimulus;transport cytosol;Golgi;nucleus catalytic activity;metal ion binding;RNA binding Pf13532 54890 ENSG00000091542.8 ALKBH5 17 Reversal of alkylation damage by DNA dioxygenases 0 High O75718 Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1 0 11.753 13 5 7 5 401 46.5 5.73 1 5 1 6 671488.6875 488976.9063 7244031.094 1 1 4 metabolic process;regulation of biological process endoplasmic reticulum;extracellular;organelle lumen protein binding 10491 ENSG00000170275.14 CRTAP 3 Collagen biosynthesis and modifying enzymes 0 High Q8WYQ5 Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1 0 31.687 14 7 7 7 773 86 5.95 7 7 256328.9688 15869683.75 375002.1973 237901.8516 1 7 2 2 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00035, Pf00397" 54487 ENSG00000128191.15 DGCR8 22 MicroRNA (miRNA) biogenesis 0 High Q9Y294 Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1 0 12.294 17 4 7 3 204 23 4.41 3 1 2 3 2 2 6642497.25 1385923.25 1068924.344 2 1 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding Pf04729 25842 ENSG00000111875.7 ASF1A 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0 High Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1 0 31.57 25 5 7 5 399 44.2 4.73 5 1 6 1 485142.4063 8287745 100277.9355 1 4 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus DNA binding;protein binding "Pf08914, Pf11626" 54386 ENSG00000166848.5 TERF2IP 16 Meiotic synapsis; DNA Damage/Telomere Stress Induced Senescence; Packaging Of Telomere Ends 0 High Q8N1F7 Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2 0 15.124 8 6 7 6 819 93.4 5.72 3 4 3 4 2494.841797 9029510.5 2534001.453 2731017.25 1 2 4 5 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;nucleus protein binding;structural molecule activity Pf04097 9688 ENSG00000102900.12 NUP93 16 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q14571 "Inositol 1,4,5-trisphosphate receptor type 2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2" 0 14.256 2 6 7 2 2701 307.9 6.43 6 1 6 1 1818949.125 482244.875 10073.74316 1 2 1 cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;nucleus metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf01365, Pf02815, Pf08454, Pf08709, Pf12670" 3709 ENSG00000123104.11 ITPR2 12 Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; Ca2+ pathway; DAG and IP3 signaling; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Elevation of cytosolic Ca2+ levels; Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis Dopaminergic synapse; Serotonergic synapse; NOD-like receptor signaling pathway; Vascular smooth muscle contraction; Glutamatergic synapse; cGMP-PKG signaling pathway; Renin secretion; Oxytocin signaling pathway; Long-term potentiation; Gap junction; Phosphatidylinositol signaling system; Glucagon signaling pathway; Thyroid hormone synthesis; Pancreatic secretion; Apoptosis; Proteoglycans in cancer; Alzheimer's disease; Long-term depression; Aldosterone synthesis and secretion; Retrograde endocannabinoid signaling; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Estrogen signaling pathway; Cholinergic synapse; Calcium signaling pathway; Platelet activation 0 High P51571 Translocon-associated protein subunit delta OS=Homo sapiens OX=9606 GN=SSR4 PE=1 SV=1 0 14.042 31 4 7 4 173 19 6.15 1 1 4 1 1 5 10489618 5126529.453 23576071.3 1 3 4 endoplasmic reticulum;membrane Pf05404 6748 ENSG00000180879.13 SSR4 X SRP-dependent cotranslational protein targeting to membrane Protein processing in endoplasmic reticulum 0 High O00264 Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3 0 9.97 20 4 7 4 195 21.7 4.7 3 3 4 3 889822.125 5269194.625 6835670.063 5506978.25 1 2 3 3 transport endoplasmic reticulum;membrane protein binding Pf00173 10857 ENSG00000101856.9 PGRMC1 X Neutrophil degranulation 0 High Q9Y3T9 Nucleolar complex protein 2 homolog OS=Homo sapiens OX=9606 GN=NOC2L PE=1 SV=4 0 24.151 9 5 7 5 749 84.9 5.62 5 1 6 1 823043.625 11788229 829104.6172 442461.5313 1 4 3 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding;RNA binding Pf03715 26155 ENSG00000188976.10 NOC2L 1 Regulation of TP53 Activity through Phosphorylation 0 High Q9NX63 MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1 0 14.656 18 4 7 4 227 26.1 8.28 1 2 2 2 1 2 2 2 3975712.375 2757740.938 1053346.469 2 2 3 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion;nucleus protein binding;structural molecule activity "Pf05300, Pf06747" 54927 ENSG00000106554.11 CHCHD3 7 Cristae formation; Mitochondrial protein import; Metabolism of proteins 0 High P02786 Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2 0 22.096 11 7 7 7 760 84.8 6.61 2 5 2 5 1546824.5 5141309.5 7460397.563 1 7 7 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endosome;extracellular;membrane protein binding;receptor activity;RNA binding;transporter activity "Pf02225, Pf04253, Pf04389" 7037 ENSG00000072274.12 TFRC 3 Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; Golgi Associated Vesicle Biogenesis Endocytosis; HIF-1 signaling pathway; Hematopoietic cell lineage; Phagosome 0 High Q9HAU5 Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1 0 26.378 6 7 7 7 1272 147.7 5.69 7 7 899138.4844 11925243.63 10167.36816 3 5 1 metabolic process;transport cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf02854, Pf04050" 26019 ENSG00000151461.19 UPF2 10 Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High Q8WXA9 Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1 0 34.717 17 6 7 6 508 59.3 10.39 6 7 16812767.88 2131612.852 1333515.5 6 3 2 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 140890 ENSG00000153914.15 SREK1 5 0 High P54886 Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2 0 10.588 8 5 7 5 795 87.2 7.12 3 1 3 3 1 3 393300.875 11749931.81 1253856.582 1353129.748 2 4 3 3 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00171, Pf00696" 5832 ENSG00000059573.8 ALDH18A1 10 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 High Q96PV6 Leukocyte receptor cluster member 8 OS=Homo sapiens OX=9606 GN=LENG8 PE=1 SV=3 0 28.833 12 7 7 7 800 88.1 9.11 7 7 15101930.75 255967.75 366675.2188 6 1 1 0 High P00338 L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2 0 10.584 13 4 7 4 332 36.7 8.27 4 1 6 1 6799319.594 1840092.5 4 3 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00056, Pf02866" 3939 ENSG00000134333.13 LDHA 11 Pyruvate metabolism Propanoate metabolism; HIF-1 signaling pathway; Central carbon metabolism in cancer; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways; Cysteine and methionine metabolism 0 High P35232 Prohibitin OS=Homo sapiens OX=9606 GN=PHB PE=1 SV=1 0 13.147 21 5 7 5 272 29.8 5.76 1 3 3 1 3 3 1662164.875 2000344.688 3275823.438 5311377 2 3 3 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endosome;membrane;mitochondrion;nucleus DNA binding;protein binding Pf01145 5245 ENSG00000167085.11 PHB 17 Paradoxical activation of RAF signaling by kinase inactive BRAF; Processing of SMDT1; RAF activation; Signaling by RAS mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling 0 High Q9HD33 "39S ribosomal protein L47, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" 0 15.164 19 5 7 5 250 29.4 10.37 5 7 19237720 5 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf06984 57129 ENSG00000136522.13 MRPL47 3 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High O15047 Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3 0 19.951 5 6 7 6 1707 185.9 5.14 2 5 2 5 437.1944275 2522060.375 4055540 1 2 4 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus catalytic activity;protein binding;RNA binding "Pf00076, Pf00856, Pf11764, Pf14259" 9739 ENSG00000099381.17 SETD1A 16 PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Lysine degradation 0 High Q14680 Maternal embryonic leucine zipper kinase OS=Homo sapiens OX=9606 GN=MELK PE=1 SV=3 0 26.451 12 6 7 6 651 74.6 8.72 6 7 517498.2813 12011550.5 1 5 cell death;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf02149, Pf06293, Pf07714, Pf14531" 9833 ENSG00000165304.7 MELK 9 0 High P82664 "28S ribosomal protein S10, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2" 0 27.435 21 4 7 4 201 23 8 4 7 686939.8438 25549373.5 325661.125 665340.5469 2 4 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome Pf00338 55173 ENSG00000048544.5 MRPS10 6 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q16643 Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4 0 18.125 9 3 7 3 649 71.4 4.45 3 7 3643234.5 4975486.25 2666204.25 1 3 1 cell communication;cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding Pf00241 1627 ENSG00000113758.13 DBN1 5 0 High Q5JTW2 Centrosomal protein of 78 kDa OS=Homo sapiens OX=9606 GN=CEP78 PE=1 SV=1 0 18.106 10 6 7 5 689 76.3 8.18 6 1 6 1 9228417.875 4510796.969 2934611.281 5 1 2 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding 84131 ENSG00000148019.12 CEP78 9 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 1 High Q9NVP2 Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1 0 22.843 42 5 7 4 202 22.4 4.56 5 1 6 1 13414355 22444030.75 884218.6875 1268789.125 1 5 1 2 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process chromosome;nucleus protein binding Pf04729 55723 ENSG00000105011.8 ASF1B 19 1 High Q5BLP8 Neuropeptide-like protein C4ORF48 OS=Homo sapiens OX=9606 GN=C4ORF48 PE=1 SV=3 0 8.803 29 3 7 3 95 10.2 8.31 3 7 115590456 17004716.25 1 3 extracellular Pf15161 401115 ENSG00000243449.6 C4orf48 4 0 High Q93034 Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4 0 8.753 6 5 7 5 780 90.9 7.94 2 2 3 2 2 3 705338.0625 81814904.25 3899691.906 2769596.469 2 2 4 4 cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus catalytic activity;protein binding;receptor activity;transporter activity "Pf00888, Pf10557" 8065 ENSG00000166266.13 CUL5 11 Downregulation of ERBB2 signaling; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 High Q96CM3 Mitochondrial RNA pseudouridine synthase RPUSD4 OS=Homo sapiens OX=9606 GN=RPUSD4 PE=1 SV=1 0 32.262 27 7 7 7 377 42.2 9.88 7 7 2036.256104 18087949.88 870696.0547 912574.0039 1 6 2 3 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding Pf00849 84881 ENSG00000165526.8 RPUSD4 11 0 High Q8N9Q2 Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1 0 15.633 26 5 7 5 155 18.2 9.85 2 1 3 2 1 4 6148.42627 4869780.75 5127950.625 3935756.063 1 2 3 4 Met-loss+Acetyl [N-Term] metabolic process metal ion binding;protein binding Pf13917 285672 ENSG00000153006.15 SREK1IP1 5 0 High Q9ULC4 Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1 0 31.978 52 7 7 7 181 20.5 8.82 7 7 16773396.38 129008.5625 11277.62109 7 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding;RNA binding Pf01472 28985 ENSG00000232119.7 MCTS1 X 0 High Q2TB10 Zinc finger protein 800 OS=Homo sapiens OX=9606 GN=ZNF800 PE=1 SV=1 0 20.282 12 7 7 7 664 75.2 9.47 7 7 15465874.5 4788.013672 6 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13912" 168850 ENSG00000048405.9 ZNF800 7 0 High Q658Y4 Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3 0 34.174 13 6 7 6 838 93.9 6.39 6 7 1453296.25 14381413.88 3196680.879 448812.6152 1 5 2 2 "Pf14647, Pf14648" 157769 ENSG00000176853.15 FAM91A1 8 0 High Q9UBX3 Mitochondrial dicarboxylate carrier OS=Homo sapiens OX=9606 GN=SLC25A10 PE=1 SV=2 0 10.312 18 5 7 5 287 31.3 9.54 2 4 2 5 2086960.5 551901.0625 2386655.75 4259274.75 1 1 3 5 metabolic process;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf00153 1468 ENSG00000183048.11 SLC25A10 17 Gluconeogenesis; Sulfide oxidation to sulfate; Organic anion transporters Proximal tubule bicarbonate reclamation 0 High O43823 A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1 0 28.752 13 5 7 5 692 76.1 5.15 5 7 6218847.625 3 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;Golgi;membrane;mitochondrion;nucleus DNA binding;metal ion binding;protein binding;RNA binding Pf04988 10270 ENSG00000105127.8 AKAP8 19 0 High Q12931 "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" 0 11.41 5 3 7 2 704 80.1 8.21 1 2 2 2 2 3 1289675.875 1106888.531 2 2 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 10131 ENSG00000126602.10 TRAP1 16 Respiratory electron transport 0 High Q7L590 Protein MCM10 homolog OS=Homo sapiens OX=9606 GN=MCM10 PE=1 SV=2 0 26.54 9 7 7 7 875 98.1 8.75 7 7 2688588.813 18359047.25 648958.9375 559523.9805 2 7 1 2 cell proliferation;metabolic process;response to stimulus nucleus DNA binding;metal ion binding;protein binding "Pf09329, Pf09332" 55388 ENSG00000065328.16 MCM10 10 M/G1 Transition; Activation of the pre-replicative complex; Regulation of DNA replication; Activation of ATR in response to replication stress; Removal of licensing factors from origins 0 High Q969V3 Nicalin OS=Homo sapiens OX=9606 GN=NCLN PE=1 SV=2 0 23.991 15 6 7 6 563 62.9 6.89 1 5 1 6 4924465 8908579.625 3528527.688 5250241.625 1 3 6 5 metabolic process;regulation of biological process endoplasmic reticulum;membrane protein binding "Pf04389, Pf05450" 56926 ENSG00000125912.10 NCLN 19 0 High Q9NQZ2 Something about silencing protein 10 OS=Homo sapiens OX=9606 GN=UTP3 PE=1 SV=1 0 29.604 20 6 7 6 479 54.5 5.62 6 7 2238844.875 24506218.38 501811.8125 1087362.031 2 6 1 2 cell organization and biogenesis;development;metabolic process nucleus protein binding;RNA binding "Pf04000, Pf09368" 57050 ENSG00000132467.3 UTP3 4 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q9HDC9 Adipocyte plasma membrane-associated protein OS=Homo sapiens OX=9606 GN=APMAP PE=1 SV=2 0 5.633 8 4 7 4 416 46.5 6.16 1 1 3 3 1 3 10296134.94 1837790.563 4945702.422 3 3 4 metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity "Pf03088, Pf08450" 57136 ENSG00000101474.11 APMAP 20 0 High Q9HC44 Vasculin-like protein 1 OS=Homo sapiens OX=9606 GN=GPBP1L1 PE=1 SV=1 0.001 4.147 1 1 7 1 474 52.3 6.84 1 1 2 5 1749.285583 18285462 5039522 7289574.875 1 1 1 2 metabolic process;regulation of biological process nucleus DNA binding Pf15337 60313 ENSG00000159592.10 GPBP1L1 1 0 High Q9ULX3 RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1 0 14.848 25 6 7 6 412 46.6 7.18 6 7 172634.25 24083731.56 500895.75 403126.625 1 6 1 1 metabolic process cytosol;nucleus catalytic activity;metal ion binding "Pf08772, Pf15017" 28987 ENSG00000141101.12 NOB1 16 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9NQ50 "39S ribosomal protein L40, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" 0 27.191 33 5 7 5 206 24.5 9.63 5 7 400689.9063 44554306.5 1761987.039 11449.0752 2 5 3 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus;ribosome protein binding;RNA binding Pf09812 64976 ENSG00000185608.8 MRPL40 22 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q9H4A3 Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2 0 14.072 2 6 7 4 2382 250.6 6.34 4 2 5 2 2226525.297 4297900 3023585.906 3 4 5 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12202" 65125 ENSG00000060237.16 WNK1 12 Stimuli-sensing channels 1 High O00483 Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens OX=9606 GN=NDUFA4 PE=1 SV=1 0 7.333 31 3 7 3 81 9.4 9.38 2 1 3 3 1 3 170445.75 18087445.88 11711007.38 12592821.06 1 2 3 3 metabolic process;transport membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf06522 4697 ENSG00000189043.9 NDUFA4 7 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High O75147 Obscurin-like protein 1 OS=Homo sapiens OX=9606 GN=OBSL1 PE=1 SV=4 0 22.256 6 6 7 6 1896 206.8 5.63 6 7 12438517.88 1788400.5 5 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;Golgi protein binding;structural molecule activity "Pf00041, Pf00047, Pf01108, Pf07679, Pf07686, Pf13895, Pf13927" 23363 ENSG00000124006.14 OBSL1 2 Neddylation 0 High Q9BWJ5 Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1 0 26.497 84 5 7 5 86 10.1 6.35 5 7 27032573 1232256.25 1120944.25 4 1 2 metabolic process nucleus;spliceosomal complex RNA binding Pf07189 83443 ENSG00000169976.6 SF3B5 6 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High P61163 Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1 0 5.944 10 3 7 3 376 42.6 6.64 3 1 6 1 2224220.313 3834964.25 803263 265715.6875 3 1 1 1 regulation of biological process;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding Pf00022 10121 ENSG00000138107.12 ACTR1A 10 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) 0 High Q13427 Peptidyl-prolyl cis-trans isomerase G OS=Homo sapiens OX=9606 GN=PPIG PE=1 SV=2 0 10.358 5 4 7 4 754 88.6 10.29 1 1 2 2 1 1 2 3 632344.0625 3667567.531 4395269 2513106.313 1 2 2 2 metabolic process cytosol;nucleus catalytic activity;protein binding;RNA binding Pf00160 9360 ENSG00000138398.15 PPIG 2 0 High Q9UL18 Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3 0 15.694 7 5 7 1 857 97.2 9.16 1 2 1 3 1 2 1 3 403268.9688 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 26523 ENSG00000092847.11 AGO1; EIF2C1 1 Post-transcriptional silencing by small RNAs; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High O75152 Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3 0 25.019 9 6 6 6 810 89.1 8.37 6 6 13636781.81 890899.5625 6 1 metabolic process;transport metal ion binding;protein binding;RNA binding 9877 ENSG00000058673.16; ENSG00000257315.2 ZC3H11A 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing 0 High Q15572 TATA box-binding protein-associated factor RNA polymerase I subunit C OS=Homo sapiens OX=9606 GN=TAF1C PE=1 SV=2 0 21.077 10 6 6 6 869 95.2 8.59 6 6 442595.4688 9606689.641 2 5 metabolic process;regulation of biological process nucleus DNA binding;protein binding 9013 ENSG00000103168.16 TAF1C 16 SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation 0 High A6NMY6 Putative annexin A2-like protein OS=Homo sapiens OX=9606 GN=ANXA2P2 PE=5 SV=2 0 9.998 12 4 6 4 339 38.6 6.95 4 1 5 1 284184.125 7574111.125 3896592.031 971718.4063 2 3 4 2 Met-loss+Acetyl [N-Term] regulation of biological process extracellular enzyme regulator activity;metal ion binding;protein binding Pf00191 304 ANXA2P2 9 0 High Q9BQ61 Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1 0 14.754 43 5 6 5 176 18.4 9.44 5 6 14357846.38 710937.1875 5 1 protein binding 79002 ENSG00000123144.10 C19orf43; TRIR 19 0 High Q86X55 Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3 0 16.867 11 5 6 5 608 65.8 6.73 2 3 3 3 3880044.563 1565253.813 3 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf02475, Pf05175, Pf05185, Pf06325, Pf08003, Pf08241, Pf08242, Pf11531, Pf12847, Pf13649, Pf13659, Pf13847" 10498 ENSG00000142453.11 CARM1 19 "Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression; PPARA activates gene expression; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription" Endocrine resistance 0 High Q9Y6G9 Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3 0 9.19 9 4 6 4 523 56.5 6.42 2 1 2 3 1 2 496990.5156 960002.1875 1303471.75 2 1 2 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00005, Pf05783" 51143 ENSG00000144635.8 DYNC1LI1 3 COPI-independent Golgi-to-ER retrograde traffic; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High O00410 Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4 0 13.165 5 5 6 5 1097 123.6 4.94 5 6 200952.1406 8133040.75 53038116 35693.82031 2 4 1 1 regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus enzyme regulator activity;protein binding;RNA binding;transporter activity "Pf02985, Pf12755, Pf13513, Pf13646" 3843 ENSG00000065150.18 IPO5 13 vRNP Assembly 0 High O15027 Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4 0 10.498 4 4 6 4 2357 251.7 5.8 2 1 1 3 1 2 1290792.375 4196373.344 1229816.047 489961.6875 1 4 2 2 0 High Q9UNZ5 Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19ORF53 PE=1 SV=1 0 7.522 18 3 6 3 99 10.6 11.55 2 1 5 1 50546923.56 1174815.625 561446.5 3 1 1 nucleus Pf09495 28974 ENSG00000104979.8 C19orf53 19 0 High Q8WVK2 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP27 PE=1 SV=1 0 16.161 17 3 6 3 155 18.8 11.62 1 1 1 3 1 1 1 3 544062.637 2474619 20168889.03 2421960.25 3 1 4 3 metabolic process nucleus protein binding Pf08648 11017 ENSG00000124380.10 SNRNP27 2 mRNA Splicing - Major Pathway Spliceosome 0 High O43505 "Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GAT1 PE=1 SV=1" 0 9.456 8 3 6 3 415 47.1 7.2 2 2 2 4 36449.83594 956453.75 1818128.875 1 2 2 cellular component movement;metabolic process Golgi;membrane catalytic activity;metal ion binding;protein binding Pf13896 11041 ENSG00000174684.6 B3GNT1; B4GAT1 11 Keratan sulfate biosynthesis; O-linked glycosylation Glycosphingolipid biosynthesis - lacto and neolacto series; Metabolic pathways; Glycosaminoglycan biosynthesis - keratan sulfate 0 High P30837 "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=3" 0 14.912 11 5 6 5 517 57.2 6.8 3 3 3 3 92571062 3283754.188 3932399.188 2 4 3 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding Pf00171 219 ALDH1B1 9 Ethanol oxidation "Fatty acid degradation; Ascorbate and aldarate metabolism; Lysine degradation; Histidine metabolism; beta-Alanine metabolism; Pyruvate metabolism; Glycerolipid metabolism; Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Metabolic pathways; Tryptophan metabolism; Arginine and proline metabolism; Valine, leucine and isoleucine degradation" 0 High Q04726 Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2 0 4.456 3 3 6 1 772 83.4 7.2 3 6 742852.375 1 metabolic process;regulation of biological process;response to stimulus nucleus protein binding "Pf00400, Pf03920" 7090 ENSG00000140332.15 TLE3 15 Repression of WNT target genes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex 0 High Q9NWK9 Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1 0 18.506 15 5 6 5 470 53.9 5.8 5 6 132371.5469 9189112.5 888272.25 395924.9375 1 4 1 1 cell organization and biogenesis metal ion binding;protein binding Pf04438 54680 ENSG00000117174.10 ZNHIT6 1 0 High Q7Z2E3 Aprataxin OS=Homo sapiens OX=9606 GN=APTX PE=1 SV=2 0 25.889 20 5 6 5 356 40.7 9.17 5 6 47578.0625 12762428.88 1 5 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf01230, Pf11969" 54840 ENSG00000137074.18 APTX 9 0 High Q969J2 Zinc finger protein with KRAB and SCAN domains 4 OS=Homo sapiens OX=9606 GN=ZKSCAN4 PE=1 SV=1 0 18.668 14 5 6 4 545 61.5 7.61 5 6 4483738.875 629212.3125 3 1 metabolic process;regulation of biological process cytosol;nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf02023, Pf13465" 387032 ENSG00000187626.8 ZKSCAN4 6 Generic Transcription Pathway 0 High P46940 Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1 0 19.613 5 6 6 6 1657 189.1 6.48 5 1 5 1 9646044.5 636777.6875 5 1 cell growth;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus enzyme regulator activity;metal ion binding;protein binding "Pf00307, Pf00397, Pf00616, Pf03836, Pf11016" 8826 ENSG00000140575.12 IQGAP1 15 Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; RHO GTPases activate IQGAPs; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Nephrin family interactions; Paradoxical activation of RAF signaling by kinase inactive BRAF; Neutrophil degranulation; Interleukin-20 family signaling Proteoglycans in cancer; Adherens junction; Regulation of actin cytoskeleton 0 High Q14244 Ensconsin OS=Homo sapiens OX=9606 GN=MAP7 PE=1 SV=1 0 18.522 9 6 6 6 749 84 9.61 6 6 66882.42188 15416959.25 564666.625 1446870 1 5 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity 9053 ENSG00000135525.18 MAP7 6 0 High P15531 Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1 0 11.771 30 4 6 4 152 17.1 6.19 1 2 2 1 3 2 785603.875 2206817.75 3175803.188 2717724.063 1 2 3 3 cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00334 4830 ENSG00000239672.7 NME1 17 Interconversion of nucleotide di- and triphosphates Purine metabolism; Metabolic pathways; Pyrimidine metabolism 0 High Q69YN2 CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2 0 18.064 11 5 6 5 538 60.6 7.24 5 6 18943738 2050806.125 1678758.125 4 1 1 catalytic activity "Pf04676, Pf04677" 55280 ENSG00000095485.16 CWF19L1 10 0 High Q6UWL2 Sushi domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUSD1 PE=1 SV=1 0 12.245 6 4 6 4 747 82.7 6.43 4 6 948723.6875 6424516 7594927.75 5920450.875 1 1 2 4 cell surface;membrane metal ion binding;protein binding "Pf00008, Pf00084, Pf06247, Pf07645, Pf12947" 64420 ENSG00000106868.16 SUSD1 9 0 High O95104 "Splicing factor, arginine/serine-rich 15 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" 0 21.186 6 5 6 4 1147 125.8 9.55 5 6 1013079.063 4126717.188 12140.4502 1 3 1 Acetyl [N-Term] nucleus RNA binding "Pf00076, Pf04818, Pf13893, Pf14259" 57466 ENSG00000156304.14 SCAF4 21 0 High O43447 Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 0 23.391 41 4 6 4 177 19.2 8.07 4 6 14451880.13 64121.38281 3 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex catalytic activity;protein binding Pf00160 10465 ENSG00000171960.10 PPIH 1 mRNA Splicing - Major Pathway Spliceosome 0 High A2A3N6 Putative PIP5K1A and PSMD4-like protein OS=Homo sapiens OX=9606 GN=PIPSL PE=5 SV=1 0 7.495 5 4 6 1 862 95 5.71 3 1 5 1 500888.5938 291034.2813 1 1 metabolic process cytoplasm catalytic activity "Pf01504, Pf04056, Pf13519" 266971 PIPSL 10 0 High Q14CB8 Rho GTPase-activating protein 19 OS=Homo sapiens OX=9606 GN=ARHGAP19 PE=1 SV=1 0 23.035 19 6 6 6 494 55.7 9.36 6 6 4758320 842887.875 1050713 3 1 2 regulation of biological process;response to stimulus cytosol;nucleus enzyme regulator activity Pf00620 84986 ENSG00000213390.10 ARHGAP19 10 Rho GTPase cycle 0 High Q6ZNB6 NF-X1-type zinc finger protein NFXL1 OS=Homo sapiens OX=9606 GN=NFXL1 PE=1 SV=2 0 33.905 9 5 6 5 911 101.3 8.41 5 6 7073329.375 7710244.5 3 1 metabolic process;regulation of biological process membrane;nucleus DNA binding;metal ion binding 152518 ENSG00000170448.11 NFXL1 4 0 High P06576 "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" 0 9.748 9 4 6 4 529 56.5 5.4 3 2 4 2 203843.2656 44479884 6954736 6892412.031 1 1 3 3 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cell surface;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00006, Pf00306, Pf02874" 506 ENSG00000110955.8 ATP5B 12 Transcriptional activation of mitochondrial biogenesis; Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High P01023 Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3 0 14.387 3 4 6 3 1474 163.2 6.46 2 3 3 3 998608.3125 6488187.25 5825856.125 1 2 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;organelle lumen enzyme regulator activity;protein binding "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 2 ENSG00000175899.14 A2M 12 Platelet degranulation ; Degradation of the extracellular matrix; Rho GTPase cycle; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation Complement and coagulation cascades 0 High Q9H0U3 Magnesium transporter protein 1 OS=Homo sapiens OX=9606 GN=MAGT1 PE=1 SV=1 0 11.811 13 5 6 5 335 38 9.63 1 5 1 5 3660.276855 3585233.063 12633446.75 22673360.5 1 2 3 5 metabolic process;transport endoplasmic reticulum;membrane catalytic activity;transporter activity Pf04756 84061 ENSG00000102158.19 MAGT1 X Asparagine N-linked glycosylation; Neutrophil degranulation; Miscellaneous transport and binding events 0 High Q96I25 Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1 0 16.987 10 4 6 3 401 44.9 5.97 4 6 11982706.25 673103 497386.4688 3 1 1 metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf01585, Pf13893, Pf14259" 84991 ENSG00000134453.15 RBM17 10 mRNA Splicing - Major Pathway Spliceosome 0 High P04181 "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" 0 14.833 20 5 6 5 439 48.5 7.03 1 3 2 1 3 2 2916036.5 3615049.875 3 4 cell organization and biogenesis;metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;protein binding Pf00202 4942 ENSG00000065154.11 OAT 10 Amino acid synthesis and interconversion (transamination) Metabolic pathways; Arginine and proline metabolism 0 High Q8N766 ER membrane protein complex subunit 1 OS=Homo sapiens OX=9606 GN=EMC1 PE=1 SV=1 0 14.262 6 5 6 5 993 111.7 7.66 1 4 1 5 65433030.5 5451655.438 4313468.563 2 3 4 metabolic process endoplasmic reticulum;membrane "Pf07774, Pf13360" 23065 ENSG00000127463.13 EMC1 1 0 High Q8NFD5 AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=2 0 13.32 2 3 6 1 2236 236 6.73 1 2 3 1 2 3 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding "Pf01388, Pf03153, Pf09770, Pf12031" 57492 ENSG00000049618.22 ARID1B 6 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q9H3K6 BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2 PE=1 SV=1 0 20.871 41 2 6 2 86 10.1 6.52 2 2 1 2 3 1 832042 2231643.438 3807981.625 2727596.375 1 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding Pf01722 654483; 552900; 107984053 BOLA2B; BOLA2; LOC107984053 16 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling 0 High Q96CS4 Zinc finger protein 689 OS=Homo sapiens OX=9606 GN=ZNF689 PE=1 SV=1 0 18.5 15 5 6 5 500 56.9 9.8 5 6 1413427 1 cell differentiation;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 115509 ENSG00000156853.12 ZNF689 16 Generic Transcription Pathway 0 High P20290 Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1 0 18.852 24 3 6 3 206 22.2 9.38 3 6 644454.8125 14565427.63 1 3 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding Pf01849 689 ENSG00000145741.15 BTF3 5 0 High P11047 Laminin subunit gamma-1 OS=Homo sapiens OX=9606 GN=LAMC1 PE=1 SV=3 0 13.642 5 5 6 5 1609 177.5 5.12 2 4 2 4 2550930.25 7297064.156 1967954.031 1 3 3 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process extracellular;organelle lumen catalytic activity;motor activity;protein binding;structural molecule activity "Pf00052, Pf00053, Pf00055, Pf00261, Pf01576, Pf05262, Pf05483, Pf05557, Pf05667, Pf05701, Pf06008, Pf08317, Pf10174, Pf11068, Pf12128, Pf12795, Pf13166, Pf13514, Pf13868" 3915 ENSG00000135862.5 LAMC1 1 ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions Amoebiasis; Prion diseases; Pathways in cancer; Toxoplasmosis; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High O75330 Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2 0 34.417 10 5 6 5 724 84 5.83 5 6 12288097.5 1029872.688 4 1 metabolic process;regulation of biological process cell surface;cytoplasm;cytosol;membrane protein binding Pf04111 3161 ENSG00000072571.19 HMMR 5 Hyaluronan uptake and degradation; AURKA Activation by TPX2 ECM-receptor interaction 0 High Q5XKP0 MICOS complex subunit MIC13 OS=Homo sapiens OX=9606 GN=MICOS13 PE=1 SV=1 0.001 4.276 27 3 6 3 118 13.1 9.42 3 2 3 3 421651.5 23061333.38 2186082.109 4853583.5 1 1 2 2 cell organization and biogenesis membrane;mitochondrion 125988 ENSG00000174917.8 C19orf70 19 Cristae formation 0 High P22234 Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3 0 16.746 11 5 6 5 425 47 7.23 3 3 3 3 1051666.313 4721100.875 2063087.656 2 3 3 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00731, Pf01259" 10606 ENSG00000128050.8 PAICS 4 Purine ribonucleoside monophosphate biosynthesis Purine metabolism; Metabolic pathways 0 High Q02809 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2" 0 17.747 8 4 6 4 727 83.5 6.95 1 1 1 2 1 1 1 3 249705.5156 1036523.719 3647933 1 2 2 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf03171 5351 ENSG00000083444.16 PLOD1 1 Collagen biosynthesis and modifying enzymes Lysine degradation 0 High O94906 Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1 0 15.928 6 5 6 5 941 106.9 8.25 4 2 4 2 5535392.438 3729619.813 2080809.141 4 2 2 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf06424, Pf13414, Pf14559" 24148 ENSG00000101161.7 PRPF6 20 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q969G3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2 0 13.356 11 4 6 4 411 46.6 4.88 2 1 2 2 1 3 1322563.875 8895240 9635821 3343126.063 2 1 2 4 cell differentiation;cell organization and biogenesis;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf00505 6605 ENSG00000073584.18 SMARCE1 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High P12532 "Creatine kinase U-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT1A PE=1 SV=1" 0 19.739 16 5 6 5 417 47 8.34 1 1 3 1 1 1 3 1 380900.5 10263849 6359215 2009631.469 1 1 5 4 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding "Pf00217, Pf02807" 1159; 548596 ENSG00000223572.9; ENSG00000237289.9 CKMT1B; CKMT1A 15 Creatine metabolism Metabolic pathways; Arginine and proline metabolism 0 High O00257 E3 SUMO-protein ligase CBX4 OS=Homo sapiens OX=9606 GN=CBX4 PE=1 SV=3 0 24.375 10 4 6 4 560 61.3 9.36 4 6 15111794.5 2340608.188 569507.75 4 3 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf00385 8535 ENSG00000141582.14 CBX4 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins 0 High O75494 Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1 0 21.092 19 4 6 4 262 31.3 11.27 4 1 5 1 1253482 86931140.38 326323.9531 233342.8125 1 5 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10772 ENSG00000188529.14 SRSF10; LOC100996657 1 mRNA Splicing - Major Pathway Spliceosome 0 High Q9UFW8 CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2 0 17.297 32 5 6 5 167 18.8 8.95 5 6 241429.9531 20058067.75 577132.875 1 4 1 metabolic process;regulation of biological process nucleus DNA binding;protein binding 8545 ENSG00000163320.10 CGGBP1 3 0 High Q8N5U6 RING finger protein 10 OS=Homo sapiens OX=9606 GN=RNF10 PE=1 SV=2 0 16.362 10 5 6 5 811 89.9 6.92 5 6 7996033.625 129802.5703 5 1 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00097, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227" 9921 ENSG00000022840.15 RNF10 12 0 High Q8IVS2 "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" 0 20.798 13 4 6 4 390 42.9 8.72 4 6 123051.6484 12974253 1 4 metabolic process mitochondrion;organelle lumen catalytic activity;RNA binding Pf00698 27349 ENSG00000100294.12 MCAT 22 Mitochondrial Fatty Acid Beta-Oxidation Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism 0 High Q14669 E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1 0 24.622 4 5 6 5 1992 220.3 8.48 5 6 25495917.89 34763696.31 993815.8125 1346591.823 2 5 1 3 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00632, Pf02825" 9320 ENSG00000153827.13 TRIP12 2 Antigen processing: Ubiquitination & Proteasome degradation Ubiquitin mediated proteolysis 0 High Q96T21 Selenocysteine insertion sequence-binding protein 2 OS=Homo sapiens OX=9606 GN=SECISBP2 PE=1 SV=2 0 27.01 11 6 6 6 854 95.4 8.12 6 6 1686917.875 8197878.5 120013.5703 3 5 1 metabolic process;regulation of biological process mitochondrion;nucleus protein binding;RNA binding Pf01248 79048 ENSG00000187742.14 SECISBP2 9 Selenocysteine synthesis 0 High P62308 Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1 0 8.436 36 4 6 4 76 8.5 8.88 1 4 1 5 1217640 72901895.5 2223386 565613.9375 2 4 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding;structural molecule activity "Pf01423, Pf03122" 6637 ENSG00000143977.13 SNRPG 2 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome 0 High O96019 Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1 0 6.902 5 2 6 2 429 47.4 5.6 1 2 1 1 1 3 1 1 838326.0566 3643197.5 4113129.5 2801734.125 1 2 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding Pf00022 86 ENSG00000136518.16 ACTL6A 3 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; UCH proteinases; DNA Damage Recognition in GG-NER; RMTs methylate histone arginines; HATs acetylate histones 0 High Q16637 Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN1 PE=1 SV=1 0 9.629 11 3 6 3 294 31.8 6.55 2 1 1 4 1 1 2043623.688 1546039.25 2 1 cell organization and biogenesis;cellular component movement;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;RNA binding;transporter activity Pf06003 6606; 6607 ENSG00000205571.13; ENSG00000273772.4; ENSG00000277773.4; ENSG00000172062.16; ENSG00000275349.4 SMN1; SMN2 5; CHR_HSCHR5_1_CTG1_1; CHR_HSCHR5_2_CTG1_1 snRNP Assembly RNA transport 0 High P18850 Cyclic AMP-dependent transcription factor ATF-6 alpha OS=Homo sapiens OX=9606 GN=ATF6 PE=1 SV=3 0 12.914 7 4 6 4 670 74.5 8.22 4 6 2854332 4452222.609 585211.4531 3069557.594 1 2 2 4 metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;Golgi;membrane;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf06156, Pf07716" 22926 ENSG00000118217.5 ATF6 1 ATF4 activates genes; ATF6 (ATF6-alpha) activates chaperone genes Protein processing in endoplasmic reticulum; Alzheimer's disease 0 High P43307 Translocon-associated protein subunit alpha OS=Homo sapiens OX=9606 GN=SSR1 PE=1 SV=3 0 7.414 12 3 6 3 286 32.2 4.49 2 3 3 3 9147160 7027758 6730423 1 2 3 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;membrane protein binding Pf03896 6745 ENSG00000124783.12 SSR1 6 XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein processing in endoplasmic reticulum 0 High O14965 Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=2 0 17.973 19 6 6 6 403 45.8 9.39 6 6 456637.4375 17837992.88 9020750 263754.9375 2 6 1 1 cell division;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714, Pf14531" 6790 AURKA 20 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Interaction between PHLDA1 and AURKA; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; SUMOylation of DNA replication proteins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of TP53 Activity through Phosphorylation Oocyte meiosis 0 High O14579 Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3 0 21.29 12 3 6 3 308 34.5 5.12 3 6 3695781.625 3723964.273 2 5 transport cytoplasm;cytosol;Golgi;membrane protein binding;structural molecule activity Pf04733 11316 ENSG00000105669.13 COPE 19 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport 0 High O00148 ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2 0 10.413 8 4 6 4 427 49.1 5.68 3 2 1 3 2 1 322032 14727152.5 2528238.555 718303.3828 1 3 3 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf14617" 10212 ENSG00000123136.14 DDX39A 19 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing 0 High Q02040 A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2 0 24.555 12 6 6 6 695 80.7 9.73 6 6 5756692.063 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf00076 8227 ENSG00000197976.11 AKAP17A X|Y; X 0 High Q9H8V3 Protein ECT2 OS=Homo sapiens OX=9606 GN=ECT2 PE=1 SV=4 0 16.935 7 5 6 5 914 103.4 7.71 5 6 796156.7168 15376313.13 2101104 1424180.313 3 5 2 2 cell differentiation;cell division;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;nucleus enzyme regulator activity;protein binding;signal transducer activity "Pf00533, Pf00621, Pf12738" 1894 ENSG00000114346.13 ECT2 3 G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle 0 High Q8N5L8 Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1 0 23.085 44 4 6 4 163 17.6 10.3 4 6 186531.1875 22121486.75 9034.376953 1 4 1 nucleus protein binding;RNA binding Pf01918 138716 ENSG00000164967.9 RPP25L 9 Ribosome biogenesis in eukaryotes; RNA transport 0 High P06730 Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2 0 16.014 28 4 6 4 217 25.1 6.15 4 6 17788379.5 4 Met-loss+Acetyl [N-Term] defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol protein binding;RNA binding Pf01652 1977 ENSG00000151247.12 EIF4E 4 ISG15 antiviral mechanism; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mTORC1-mediated signalling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Transport of the SLBP independent Mature mRNA; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition Insulin signaling pathway; HIF-1 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mTOR signaling pathway; RNA transport; Longevity regulating pathway; PI3K-Akt signaling pathway 0 High O43795 Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3 0 9.648 4 5 6 5 1136 131.9 9.38 4 2 4 2 3607628.5 11490867.38 8511231.188 2 4 4 cell organization and biogenesis;cellular component movement;transport cytoplasm;endosome;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 4430 ENSG00000128641.18 MYO1B 2 0 High Q96G21 U3 small nucleolar ribonucleoprotein protein IMP4 OS=Homo sapiens OX=9606 GN=IMP4 PE=1 SV=1 0 9.218 11 4 6 4 291 33.7 9.47 4 6 29917333 4 metabolic process nucleus protein binding;RNA binding Pf04427 92856 ENSG00000136718.9 IMP4 2 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9BTC0 Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5 0 23.05 5 6 6 6 2240 243.7 7.88 6 6 14581489.13 212209.0156 3 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus metal ion binding;protein binding;RNA binding "Pf00628, Pf07500, Pf07744, Pf09770" 11083 ENSG00000101191.16 DIDO1 20 0 High Q99959 Plakophilin-2 OS=Homo sapiens OX=9606 GN=PKP2 PE=1 SV=2 0 20.859 7 5 6 5 881 97.4 9.33 5 1 5 1 679624.8594 15024191.69 430282.2188 393665.1016 1 5 1 2 cell communication;cell death;cell organization and biogenesis;regulation of biological process cytoskeleton;membrane;nucleus protein binding;structural molecule activity 5318 ENSG00000057294.14 PKP2 12 Formation of the cornified envelope Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0 High Q9Y3B4 Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1 0 19.565 43 5 6 5 125 14.6 9.38 5 1 5 1 24378823.75 473621.5313 83669.70996 4 1 3 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 51639 ENSG00000115128.6 SF3B14; SF3B6 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q16630 Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2 0 25.864 10 3 6 3 551 59.2 7.15 2 1 2 3 1 2 4172055.969 934236 319505.7148 2 1 2 cell organization and biogenesis;metabolic process membrane;nucleus protein binding;RNA binding "Pf00076, Pf14259" 11052 ENSG00000111605.16 CPSF6 12 Signaling by cytosolic FGFR1 fusion mutants mRNA surveillance pathway 0 High Q96IR2 Zinc finger protein 845 OS=Homo sapiens OX=9606 GN=ZNF845 PE=1 SV=3 0 20.258 3 3 6 2 970 113.1 9.33 3 6 9462869 371069.4688 4 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 91664 ENSG00000213799.11 ZNF845 19 0 High Q96PV7 Protein FAM193B OS=Homo sapiens OX=9606 GN=FAM193B PE=1 SV=3 0 24.659 10 6 6 6 902 96.5 7.9 6 6 658293.5313 11031762.25 1559849.5 5941.052734 2 6 1 1 cytoplasm;nucleus protein binding 54540 FAM193B 5 0 High P17050 Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2 0 10.587 8 3 6 3 411 46.5 5.19 1 3 1 5 7152.980957 518643 1043004.188 12064235 1 1 1 3 metabolic process cytoplasm;vacuole catalytic activity;protein binding Pf02065 4668 ENSG00000198951.11 NAGA 22 Lysosome; Glycosphingolipid biosynthesis - globo and isoglobo series 0 High O94905 Erlin-2 OS=Homo sapiens OX=9606 GN=ERLIN2 PE=1 SV=1 0 12.381 12 4 6 2 339 37.8 5.62 1 4 1 5 566780.3125 1852660.188 3609581.063 1 2 3 metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;membrane catalytic activity;protein binding Pf01145 11160 ENSG00000147475.14 ERLIN2 8 ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by plasma membrane FGFR1 fusions 2 High Q14157 Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2 0 32.092 8 6 6 6 1087 114.5 7.11 6 6 1169153.75 7895589.75 469349.9375 11121441 1 4 1 1 regulation of biological process cytoplasm protein binding;RNA binding "Pf00627, Pf12478, Pf14555" 9898 ENSG00000143569.18 UBAP2L 1 0 High Q9Y5J9 Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1 0 17.63 61 5 6 5 83 9.3 5.12 1 5 1 5 1287394.938 31941305.63 404715.2813 466111.5156 2 5 1 2 Met-loss+Acetyl [N-Term] transport membrane;mitochondrion metal ion binding;transporter activity Pf02953 26521 ENSG00000150779.11 TIMM8B 11 Mitochondrial protein import; Metabolism of proteins 0 High Q9H078 Caseinolytic peptidase B protein homolog OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1 0 13.036 6 3 6 3 707 78.7 9.01 2 1 2 2 2 2 703248.0625 2970314.563 1111605.813 284223.2188 1 2 2 1 response to stimulus mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00023, Pf06309, Pf06414, Pf07724, Pf07728, Pf10431, Pf12796, Pf13401, Pf13606, Pf13637, Pf13857" 81570 ENSG00000162129.12 CLPB 11 Longevity regulating pathway - multiple species 0 High Q9H9J2 "39S ribosomal protein L44, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" 0 21.909 18 5 6 5 332 37.5 8.4 5 1 5 1 746083.3281 16450734.75 669538.25 13576.9707 2 5 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus;ribosome catalytic activity;protein binding;RNA binding Pf00636 65080 ENSG00000135900.3 MRPL44 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High P12268 Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2 0 11.061 11 4 6 4 514 55.8 6.9 1 3 3 3 1738006.875 4052213.063 3715813 1 3 3 cell organization and biogenesis;cell proliferation;metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00478, Pf00571, Pf00977, Pf01070, Pf03060" 3615 ENSG00000178035.11 IMPDH2 3 Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis Purine metabolism; Metabolic pathways; Drug metabolism - other enzymes 0 High P08069 Insulin-like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1 0 16.546 5 6 6 6 1367 154.7 5.8 2 4 2 4 1571028.688 1414076.125 2195760.563 3877924.313 2 1 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00041, Pf00069, Pf00757, Pf01030, Pf01826, Pf07714, Pf14843" 3480 ENSG00000140443.13 IGF1R 15 IRS-related events triggered by IGF1R; SHC-related events triggered by IGF1R Endocytosis; Longevity regulating pathway - multiple species; HIF-1 signaling pathway; Ovarian steroidogenesis; FoxO signaling pathway; Rap1 signaling pathway; Progesterone-mediated oocyte maturation; Breast cancer; Pathways in cancer; Prostate cancer; Glioma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Focal adhesion; Proteoglycans in cancer; AMPK signaling pathway; mTOR signaling pathway; Transcriptional misregulation in cancer; Adherens junction; Long-term depression; Oocyte meiosis; Ras signaling pathway; Endocrine resistance; Signaling pathways regulating pluripotency of stem cells; Longevity regulating pathway; PI3K-Akt signaling pathway 0 High O95470 Sphingosine-1-phosphate lyase 1 OS=Homo sapiens OX=9606 GN=SGPL1 PE=1 SV=3 0 26.329 16 6 6 6 568 63.5 9.16 6 6 1936447.25 13745961.25 69478.09375 301446.3486 1 5 1 2 cell death;cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00155, Pf00266, Pf00282, Pf01053, Pf05889" 8879 ENSG00000166224.16 SGPL1 10 Sphingolipid de novo biosynthesis Sphingolipid metabolism; Sphingolipid signaling pathway; Metabolic pathways 0 High P28300 Protein-lysine 6-oxidase OS=Homo sapiens OX=9606 GN=LOX PE=1 SV=2 0 13.954 14 4 6 4 417 46.9 8.09 1 3 2 4 928214.6875 3207929.156 1 3 cell organization and biogenesis;metabolic process;response to stimulus extracellular;nucleus catalytic activity;metal ion binding;protein binding Pf01186 4015 ENSG00000113083.13 LOX 5 Elastic fibre formation; Crosslinking of collagen fibrils 0 High Q9Y2A7 Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1 0 14.822 4 4 6 4 1128 128.7 6.62 3 1 1 3 2 1 2262981.188 8071538.953 5110763.75 2 2 2 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus cytosol;membrane protein binding Pf09735 10787 ENSG00000061676.14 NCKAP1 2 Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs Regulation of actin cytoskeleton 0 High P50990 T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4 0 13.112 8 4 6 4 548 59.6 5.6 4 1 5 1 2420529 1286119.5 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;organelle lumen catalytic activity;nucleotide binding;protein binding Pf00118 10694 ENSG00000156261.12 CCT8 21 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC 0 High Q6P4A7 Sideroflexin-4 OS=Homo sapiens OX=9606 GN=SFXN4 PE=1 SV=1 0 12.376 11 3 6 3 337 38 9.19 1 1 3 1 1 4 226127.1719 5439263.125 2014295.719 2577216.813 1 2 3 3 transport membrane;mitochondrion transporter activity Pf03820 119559 ENSG00000183605.16 SFXN4 10 0 High Q86SE5 RNA-binding Raly-like protein OS=Homo sapiens OX=9606 GN=RALYL PE=1 SV=2 0 7.276 7 2 6 1 291 32.3 7.93 1 2 1 5 3974017.25 580831.125 1 1 nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 138046 ENSG00000184672.11 RALYL 8 0 High P57772 Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4 0 24.021 14 6 6 6 596 65.3 8.35 6 6 614192.7813 10043939.75 890064.3438 2014021.658 3 5 2 2 metabolic process;regulation of biological process cytoplasm;mitochondrion;nucleus catalytic activity;nucleotide binding;RNA binding "Pf00009, Pf03144" 60678 ENSG00000132394.10 EEFSEC 3 Selenocysteine synthesis 0 High Q9UK22 F-box only protein 2 OS=Homo sapiens OX=9606 GN=FBXO2 PE=1 SV=2 0 19.038 20 5 6 5 296 33.3 4.37 1 5 1 5 721965.75 2264676.75 5076090.531 1 2 3 metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;membrane catalytic activity;protein binding Pf04300 26232 ENSG00000116661.9 FBXO2 1 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 0 High Q96GC5 "39S ribosomal protein L48, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL48 PE=1 SV=2" 0 14.033 18 4 6 4 212 23.9 8.98 4 6 41529135 4 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding Pf00338 51642 ENSG00000175581.13 MRPL48 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q9Y291 "28S ribosomal protein S33, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS33 PE=1 SV=1" 0 13.168 35 4 6 4 106 12.6 10.11 4 6 301817.5313 18457060.25 11268391 11753091.15 1 4 1 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf08293 51650 ENSG00000090263.15 MRPS33 7 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High A8MTY0 Zinc finger protein 724 OS=Homo sapiens OX=9606 GN=ZNF724 PE=2 SV=3 0 10.711 11 4 6 2 619 71.1 9.11 4 1 5 1 20199951.75 1218881.25 4 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 440519 ENSG00000196081.9 ZNF724P; ZNF724 19 Generic Transcription Pathway 2 High O75530 Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2 0 19.056 14 5 6 5 441 50.2 7.03 5 6 1265635.422 13296822.5 568817.5 4 5 1 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytosol;nucleus catalytic activity;DNA binding;protein binding Pf00400 8726 ENSG00000074266.19 EED 11 Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence 0 High Q8N684 Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1 0 17.478 11 5 6 5 471 52 8 5 6 356025.0625 17473364 1790829.313 2397381.5 1 5 2 2 cell organization and biogenesis;metabolic process membrane;nucleus protein binding;RNA binding "Pf00076, Pf14259" 79869 ENSG00000149532.15 CPSF7 11 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High Q5T750 Skin-specific protein 32 OS=Homo sapiens OX=9606 GN=XP32 PE=1 SV=1 0.001 3.693 8 2 6 2 250 26.2 7.97 2 1 1 2 2 2 778745 25267164 3702358.5 1977615.234 1 1 1 1 cell differentiation;metabolic process cytoplasm;cytoskeleton structural molecule activity 100129271 ENSG00000198854.5 C1orf68 1 0 High P41214 Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3 0 18.99 13 6 6 6 584 64.7 7.65 6 6 11682484.5 65037.29297 10904.26953 4 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol protein binding;receptor activity;RNA binding "Pf01253, Pf01472" 1939 ENSG00000143486.15 EIF2D 1 0 High Q12891 Hyaluronidase-2 OS=Homo sapiens OX=9606 GN=HYAL2 PE=1 SV=4 0 12.558 7 4 6 4 473 53.8 8.19 1 4 1 5 1269669.844 2944692.406 2 2 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endoplasmic reticulum;membrane;vacuole catalytic activity;enzyme regulator activity;protein binding;receptor activity Pf01630 8692 ENSG00000068001.13 HYAL2 3 Hyaluronan uptake and degradation Glycosaminoglycan degradation; Metabolic pathways 0 High P08754 Guanine nucleotide-binding protein G(k) subunit alpha OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3 0 10.123 10 3 6 3 354 40.5 5.69 1 3 1 1 4 1 411687.875 3913798.625 4960415.375 1184243.656 1 2 3 2 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;Golgi;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503" 2773 ENSG00000065135.10 GNAI3 1 G alpha (z) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (s) signalling events; PLC beta mediated events; ADP signalling through P2Y purinoceptor 12; Adenylate cyclase inhibitory pathway; G-protein activation Dopaminergic synapse; Chagas disease (American trypanosomiasis); Serotonergic synapse; Tight junction; Glutamatergic synapse; cGMP-PKG signaling pathway; Renin secretion; Rap1 signaling pathway; Progesterone-mediated oocyte maturation; Oxytocin signaling pathway; Circadian entrainment; Morphine addiction; Pathways in cancer; Gap junction; Adrenergic signaling in cardiomyocytes; Pertussis; Toxoplasmosis; Melanogenesis; Parkinson's disease; Long-term depression; Retrograde endocannabinoid signaling; Leukocyte transendothelial migration; Cocaine addiction; Sphingolipid signaling pathway; Gastric acid secretion; GABAergic synapse; Alcoholism; Chemokine signaling pathway; Axon guidance; cAMP signaling pathway; Estrogen signaling pathway; Regulation of lipolysis in adipocytes; Cholinergic synapse; Platelet activation 0 High P09429 High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3 0 28.848 35 5 6 4 215 24.9 5.74 5 6 263271.8438 17500537 353789.2188 506621.1875 1 4 1 1 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;chromosome;cytoplasm;endosome;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding "Pf00505, Pf09011" 3146 ENSG00000189403.14 HMGB1 13 TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Neutrophil degranulation; Regulation of TLR by endogenous ligand; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activation of DNA fragmentation factor Base excision repair 1 High Q6KB66 "Keratin, type II cytoskeletal 80 OS=Homo sapiens OX=9606 GN=KRT80 PE=1 SV=2" 0 5.839 6 2 6 1 452 50.5 5.67 2 1 1 1 2 1 2 1 224439.875 1063365.25 1 1 cell death;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity;transporter activity "Pf00038, Pf01496, Pf05557, Pf12128, Pf13166" 144501 ENSG00000167767.13 KRT80 12 Formation of the cornified envelope 0 High Q15475 Homeobox protein SIX1 OS=Homo sapiens OX=9606 GN=SIX1 PE=1 SV=1 0 11.5 22 4 5 3 284 32.2 9.14 4 5 2978926 844734.5 3 1 Met-loss+Acetyl [N-Term] cell communication;cell death;cell differentiation;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus DNA binding;protein binding;transporter activity "Pf00046, Pf05920" 6495 ENSG00000126778.8 SIX1 14 Transcriptional misregulation in cancer 1 Low Q96Q89 Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3 0.069 0.915 0 1 5 1 1820 210.5 5.67 1 1 1 1 3 1 77067768 112093120 152088112 259953338.4 1 1 1 1 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf01576, Pf02463, Pf03961, Pf07851, Pf09726" 9585 ENSG00000138182.14 KIF20B 10 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins 0 High Q15291 Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2 0 12.606 9 4 5 4 538 59.1 5.1 2 3 2 3 2856232.078 1884568.75 2208458.438 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding Pf00400 5929 ENSG00000117222.13 RBBP5 1 Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex; Neddylation 0 High Q12894 Interferon-related developmental regulator 2 OS=Homo sapiens OX=9606 GN=IFRD2 PE=1 SV=3 0 17.857 9 3 5 3 506 54.8 7.94 3 5 2652649.711 7376.570801 3 1 nucleus protein binding "Pf04836, Pf05004" 7866 ENSG00000214706.10 IFRD2 3 0 High Q9Y2G8 DnaJ homolog subfamily C member 16 OS=Homo sapiens OX=9606 GN=DNAJC16 PE=2 SV=3 0 6.713 4 4 5 4 782 90.5 7.12 1 3 1 4 202824.875 9451876.313 1700496.719 1140910.625 1 3 2 2 cellular homeostasis;regulation of biological process cytosol;membrane "Pf00085, Pf00226" 23341 ENSG00000116138.12 DNAJC16 1 0 High P04196 Histidine-rich glycoprotein OS=Homo sapiens OX=9606 GN=HRG PE=1 SV=1 0 4.444 3 2 5 2 525 59.5 7.5 2 2 3 2 4369216.375 3765357.625 2 2 coagulation;defense response;regulation of biological process;response to stimulus;transport cell surface;endosome;extracellular;membrane;organelle lumen;vacuole enzyme regulator activity;metal ion binding;protein binding 3273 ENSG00000113905.4 HRG 3 Platelet degranulation ; Dissolution of Fibrin Clot 0 High Q8N972 Zinc finger protein 709 OS=Homo sapiens OX=9606 GN=ZNF709 PE=2 SV=1 0 10.423 5 3 5 1 641 74.6 8.95 3 5 5251696 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 163051 ENSG00000242852.6; ENSG00000196826.7 ZNF709 19 Generic Transcription Pathway 0 High Q9UI10 Translation initiation factor eIF-2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2 0 28.178 14 5 5 5 523 57.5 9.38 5 5 104545.0391 12241252.25 1161316.5 1 5 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol protein binding;RNA binding Pf01008 8890 ENSG00000115211.15 EIF2B4 2 Recycling of eIF2:GDP RNA transport 0 High Q15361 Transcription termination factor 1 OS=Homo sapiens OX=9606 GN=TTF1 PE=1 SV=3 0 24.47 9 5 5 5 905 103 9.38 5 5 7721773.5 11547319.25 719969.75 1 4 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytosol;membrane;nucleus DNA binding Pf13921 7270 ENSG00000125482.12 TTF1 9 Surfactant metabolism; Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS); RNA Polymerase I Transcription Termination; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation Thyroid hormone synthesis 0 High Q5VUD6 Divergent protein kinase domain 1B OS=Homo sapiens OX=9606 GN=DIPK1B PE=1 SV=3 0 12.024 13 4 5 4 431 48.6 8.68 4 5 259450.3438 2643485.688 1 3 endoplasmic reticulum;membrane protein binding "Pf12260, Pf14875" 138311 ENSG00000165716.10 FAM69B 9 0 High O60333 Kinesin-like protein KIF1B OS=Homo sapiens OX=9606 GN=KIF1B PE=1 SV=5 0 18.688 3 5 5 3 1816 204.3 5.6 5 5 2407890.5 5109583.375 1674030.5 154271.7813 1 3 1 1 cell communication;cell death;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;mitochondrion catalytic activity;motor activity;nucleotide binding;protein binding "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473" 23095 ENSG00000054523.17 KIF1B 1 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins 1 High Q14008 Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3 0 11.219 4 4 5 4 2032 225.4 7.8 3 1 1 3 1 1 3933959 7688574.5 1099032.711 932852.8438 1 2 2 2 cell division;cell organization and biogenesis;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane protein binding Pf12348 9793 ENSG00000175216.14 CKAP5 11 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins 0 High Q96TA2 ATP-dependent zinc metalloprotease YME1L1 OS=Homo sapiens OX=9606 GN=YME1L1 PE=1 SV=2 0 18.214 9 5 5 5 773 86.4 8.76 3 2 3 2 262744.4688 565346.9375 3117213.625 4745916.875 1 1 4 5 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00004, Pf01434" 10730 ENSG00000136758.18 YME1L1 10 Processing of SMDT1 0 High Q9NVU7 Protein SDA1 homolog OS=Homo sapiens OX=9606 GN=SDAD1 PE=1 SV=3 0 13.49 7 4 5 4 687 79.8 9.25 4 5 2452184.82 22132919 4523.58252 3 4 1 cell organization and biogenesis;transport nucleus "Pf05285, Pf08158" 55153 ENSG00000198301.11 SDAD1 4 0 High O00505 Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2 0 15.49 13 4 5 4 521 57.8 4.94 4 1 4 1 7809336.25 768974.5625 3 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;transporter activity "Pf00514, Pf01602, Pf01749, Pf13513, Pf13646" 3839 ENSG00000102753.9 KPNA3 13 NS1 Mediated Effects on Host Pathways; ISG15 antiviral mechanism 0 High Q9BWF3 RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1 0 10.185 16 4 5 4 364 40.3 7.08 3 1 4 1 304628.6563 9655390.125 819836.875 347983.9063 1 3 2 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf00098, Pf13893, Pf14259" 5936 ENSG00000173933.19 RBM4 11 "BMAL1:CLOCK,NPAS2 activates circadian gene expression" 0 High P30419 Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2 0 14.858 9 4 5 4 496 56.8 7.8 4 5 68343.4375 11597930.63 891773.4375 1 4 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion catalytic activity "Pf01233, Pf02799" 4836 ENSG00000136448.11 NMT1 17 "Signaling by GPCR; Activation, myristolyation of BID and translocation to mitochondria; Late Phase of HIV Life Cycle; Inactivation, recovery and regulation of the phototransduction cascade" 0 High Q9NU22 Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2 0 15.661 1 5 5 5 5596 632.4 5.68 2 3 2 3 3648096.75 235082 329966.5938 3 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00092, Pf02367, Pf07726, Pf07728, Pf13401, Pf13671" 23195 ENSG00000112159.11 MDN1 6 Ribosome biogenesis in eukaryotes 0 High Q9BQ70 Transcription factor 25 OS=Homo sapiens OX=9606 GN=TCF25 PE=1 SV=1 0 16.628 10 4 5 4 676 76.6 6.35 4 5 14426177.05 7418020.5 1821271.922 2350689.25 2 3 2 1 metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf04910 22980 ENSG00000141002.19 TCF25 16 0 High Q15390 Mitochondrial fission regulator 1 OS=Homo sapiens OX=9606 GN=MTFR1 PE=1 SV=2 0 14.268 11 3 5 3 333 37 9.01 2 1 4 1 902477.8125 9891739.125 1442408.375 1 3 2 cell organization and biogenesis;metabolic process cytosol;membrane;mitochondrion Pf05308 9650 ENSG00000066855.15 MTFR1 8 0 High Q96DI7 U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1 0 13.349 25 5 5 5 357 39.3 8.1 4 1 4 1 173963808.4 142701.6563 3 1 cell organization and biogenesis;metabolic process cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf00400 9410 ENSG00000060688.12 SNRNP40 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q92830 Histone acetyltransferase KAT2A OS=Homo sapiens OX=9606 GN=KAT2A PE=1 SV=3 0 8.556 5 4 5 4 837 93.9 9.04 3 1 4 1 17658408.75 6698305.188 4569275.156 2 4 4 cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;protein binding "Pf00439, Pf00583, Pf06466, Pf13508, Pf13673" 2648 ENSG00000108773.10 KAT2A 17 NOTCH1 Intracellular Domain Regulates Transcription; Ub-specific processing proteases; HATs acetylate histones; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates NOTCH signaling; Pre-NOTCH Transcription and Translation; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation Viral carcinogenesis; Thyroid hormone signaling pathway; HTLV-I infection; Notch signaling pathway 0 High Q9BS26 Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1 0 10.113 10 4 5 4 406 46.9 5.26 1 4 1 4 11145773.42 3117820.063 2538801.484 1991450.063 2 1 3 4 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00085, Pf01216, Pf07449, Pf13098, Pf13848" 23071 ENSG00000023318.7 ERP44 9 Neutrophil degranulation 0 High O75477 Erlin-1 OS=Homo sapiens OX=9606 GN=ERLIN1 PE=1 SV=2 0 8.721 9 3 5 1 348 39.1 7.87 2 2 2 3 1424330.375 32520142 1 1 0 High Q9NYL2 Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20 PE=1 SV=3 0 23.7 7 4 5 4 800 91.1 7.87 4 5 10916441.88 135541.4531 618622 4 1 1 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding;signal transducer activity "Pf00069, Pf00536, Pf07714" 51776 ENSG00000091436.16 ZAK; MAP3K20 2 Tight junction; MAPK signaling pathway 0 High Q8ND56 Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3 0 10.705 6 4 5 4 463 50.5 9.52 4 5 10286833.25 558279.5 3 1 cell organization and biogenesis;defense response;development;regulation of biological process;response to stimulus cytoplasm;cytosol DNA binding;RNA binding "Pf09532, Pf12701, Pf14438" 26065 ENSG00000262860.5; ENSG00000257103.8 LSM14A 19; CHR_HSCHR19_1_CTG3_1 0 High Q6ZN08 Putative zinc finger protein 66 OS=Homo sapiens OX=9606 GN=ZNF66 PE=5 SV=3 0 5.355 8 3 5 1 573 65.8 9.33 3 1 4 1 1520.629883 70166696 168062.0313 1 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 7617 ENSG00000160229.11 ZNF66; ZNF66P 19 0 High Q96EP5 DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1 0 9.668 12 3 5 3 407 43.4 8.56 1 1 2 1 1 1 2 1 1631449.813 1906552.344 3100807 827945.3125 1 1 1 1 cell differentiation;cell proliferation;development;regulation of biological process cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 26528 ENSG00000071626.16 DAZAP1 19 mRNA surveillance pathway 0 High Q92769 Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2 0 10 8 3 5 1 488 55.3 5.91 2 1 1 3 1 1 512142.3125 269734.375 1 1 cell differentiation;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf00850 3066 ENSG00000196591.11 HDAC2 6 NOTCH1 Intracellular Domain Regulates Transcription; Regulation of TP53 Activity through Acetylation; NoRC negatively regulates rRNA expression; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Factors involved in megakaryocyte development and platelet production; SUMOylation of chromatin organization proteins; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; HDACs deacetylate histones; p75NTR negatively regulates cell cycle via SC1; Signalling by NGF; RNA Polymerase I Transcription Initiation Viral carcinogenesis; Longevity regulating pathway - multiple species; Chronic myeloid leukemia; Epstein-Barr virus infection; Huntington's disease; Pathways in cancer; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer; Notch signaling pathway; Alcoholism; Cell cycle 0 High Q9BQ52 Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2 0 14.732 9 5 5 5 826 92.2 7.9 5 5 127424.1016 11609718.63 1 5 cell organization and biogenesis;metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;RNA binding "Pf00753, Pf12706, Pf13691" 60528 ENSG00000006744.18 ELAC2 17 tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA processing in the nucleus RNA transport 0 High Q86U38 Nucleolar protein 9 OS=Homo sapiens OX=9606 GN=NOP9 PE=1 SV=1 0 26.504 12 4 5 4 636 69.4 7.28 4 5 4648969.5 6437704.313 26863.40625 108404.6982 1 3 1 2 RNA binding 161424 ENSG00000196943.12 NOP9 14 0 High P11177 "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" 0 8.849 17 4 5 4 359 39.2 6.65 1 1 1 2 1 1 1 2 1174762.656 13963924.91 1646075.063 1289181.938 2 3 2 2 metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen catalytic activity;protein binding "Pf02779, Pf02780" 5162 ENSG00000168291.12 PDHB 3 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High P82921 "28S ribosomal protein S21, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS21 PE=1 SV=3" 0 11.612 39 3 5 3 87 10.7 9.92 3 1 4 1 18697733 528017.7734 3322.739502 3 2 1 0 High Q14839 Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2 0 18.798 4 5 5 3 1912 217.9 5.86 5 5 82995.15625 1938836.625 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00176, Pf00271, Pf00385, Pf00628, Pf04851, Pf06461, Pf06465, Pf08073, Pf08074, Pf13831" 1108 ENSG00000111642.14 CHD4 12 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation Viral carcinogenesis 0 High P26358 DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2 0 15.471 4 5 5 5 1616 183.1 7.75 5 5 3057470 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" 1786 ENSG00000130816.14 DNMT1 19 PRC2 methylates histones and DNA; DNA methylation; NoRC negatively regulates rRNA expression MicroRNAs in cancer; Metabolic pathways; Cysteine and methionine metabolism 0 High Q5BKZ1 DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2 0 14.961 10 5 5 5 582 65.6 5.15 3 2 3 2 6972185.25 444034.0938 178368.3594 3 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex DNA binding;metal ion binding;protein binding;RNA binding Pf04988 284695 ENSG00000162664.16 ZNF326 1 0 High Q9BWC9 Coiled-coil domain-containing protein 106 OS=Homo sapiens OX=9606 GN=CCDC106 PE=1 SV=1 0 16.251 22 5 5 5 280 32 9.42 5 5 1877374.375 9543054.688 326720.5625 132394.4375 1 4 1 1 cytosol;nucleus protein binding 29903 ENSG00000173581.7 CCDC106 19 0 High Q6UXN9 WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1 0 7.524 11 4 5 4 313 35.1 7.69 4 1 4 1 9116948.25 1198240.75 1691325.781 3 2 2 cell organization and biogenesis;metabolic process chromosome;membrane;nucleus catalytic activity;protein binding Pf00400 80335 ENSG00000164091.11 WDR82 3 mRNA surveillance pathway 0 High O15234 Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2 0 17.779 7 4 5 4 703 76.2 6.48 4 5 10197996.38 95317.60156 4 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf09405 22794 ENSG00000108349.16 CASC3 17 mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High Q9P2J8 Zinc finger protein 624 OS=Homo sapiens OX=9606 GN=ZNF624 PE=1 SV=3 0 10.514 5 4 5 3 865 99.9 8.88 4 5 200494.0781 195674575.9 1 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf13465" 57547 ENSG00000197566.9 ZNF624 17 Generic Transcription Pathway 0 High Q16531 DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1 0 11.923 5 3 5 3 1140 126.9 5.26 2 1 1 2 1 2 675395.3125 765809.25 1155832.125 785515.9375 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding "Pf03178, Pf10433" 1642 ENSG00000167986.13 DDB1 11 Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Neddylation Viral carcinogenesis; Hepatitis B; Ubiquitin mediated proteolysis; Nucleotide excision repair 0 High O43896 Kinesin-like protein KIF1C OS=Homo sapiens OX=9606 GN=KIF1C PE=1 SV=3 0 19.483 5 5 5 3 1103 122.9 6.9 5 5 29976438 2710765.375 1 2 cellular component movement;transport cytoplasm;cytoskeleton;endoplasmic reticulum;Golgi catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00225, Pf00498" 10749 ENSG00000129250.11 KIF1C 17 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins 0 High Q9H0W5 Coiled-coil domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CCDC8 PE=1 SV=2 0 20.016 21 5 5 5 538 59.3 8.63 5 5 1794308.125 4335824.063 1567844.188 1 3 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding Pf14893 83987 ENSG00000169515.5 CCDC8 19 Neddylation 0 High Q9Y324 rRNA-processing protein FCF1 homolog OS=Homo sapiens OX=9606 GN=FCF1 PE=2 SV=1 0 14.753 21 4 5 4 198 23.4 9.7 4 5 19680494 1239408.219 648800 4 2 1 metabolic process nucleus RNA binding Pf04900 51077 ENSG00000119616.11 FCF1 14 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9HCN8 Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2 0 17.708 26 4 5 4 221 23.6 7.03 4 5 12465727.75 1792777 1815353.125 3 1 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding Pf02815 23753 ENSG00000128228.4 SDF2L1 22 0 High Q9NV79 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCMTD2 PE=2 SV=2 0 13.026 15 4 5 4 361 41 6.11 1 1 3 1 1 3 1743711.063 8293708.25 2628664.125 4457462 2 2 3 3 metabolic process cytoplasm catalytic activity "Pf01135, Pf08242, Pf12847, Pf13847" 55251 ENSG00000280663.4; ENSG00000203880.11 PCMTD2 20; CHR_HSCHR20_1_CTG3 0 High Q9NRB3 Carbohydrate sulfotransferase 12 OS=Homo sapiens OX=9606 GN=CHST12 PE=2 SV=2 0 6.429 8 4 5 4 414 48.4 9.32 2 2 3 2 191886581.8 3724311.688 3046810.438 2 4 3 metabolic process Golgi;membrane catalytic activity;nucleotide binding Pf03567 55501 ENSG00000136213.9 CHST12 7 Chondroitin sulfate biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High O00562 Membrane-associated phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNM1 PE=1 SV=4 0 9.192 4 4 5 3 1244 134.8 5.95 2 3 2 3 2325130.75 1626294.406 3 3 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane metal ion binding;protein binding;transporter activity "Pf02121, Pf02862, Pf08235" 9600 ENSG00000110697.12 PITPNM1 11 Synthesis of PI 0 High Q6NUS6 Tectonic-3 OS=Homo sapiens OX=9606 GN=TCTN3 PE=1 SV=2 0 14.301 10 4 5 4 607 66.1 8.21 4 5 2278879.5 5157510.438 1 4 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus membrane;nucleus Pf07773 26123 ENSG00000119977.20 TCTN3 10 Anchoring of the basal body to the plasma membrane 0 High P29803 "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA2 PE=1 SV=1" 0 6.118 7 3 5 1 388 42.9 8.46 2 1 2 2 1 2 4819824 1 Met-loss [N-Term] metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen catalytic activity Pf00676 5161 ENSG00000163114.5 PDHA2 4 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High Q9NR50 Translation initiation factor eIF-2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1 0 15.053 17 5 5 5 452 50.2 6.47 5 5 6983825.75 1427040.438 1089430.422 3 2 2 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;protein binding;RNA binding "Pf00483, Pf02348, Pf12804" 8891 ENSG00000070785.16 EIF2B3 1 Recycling of eIF2:GDP RNA transport 0 High Q15649 Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2 0 10.735 32 3 5 3 155 17.6 5.67 3 5 183294.6406 9303218 1 3 regulation of biological process cytoplasm;nucleus metal ion binding;protein binding Pf04438 9326 ENSG00000273611.4; ENSG00000278574.4 ZNHIT3 17; CHR_HSCHR17_7_CTG4 0 High Q13595 Transformer-2 protein homolog alpha OS=Homo sapiens OX=9606 GN=TRA2A PE=1 SV=1 0 10.885 15 5 5 3 282 32.7 11.27 5 5 259312.8594 18321841.75 25335.50195 1306937.11 1 3 1 2 metabolic process nucleus RNA binding "Pf00076, Pf13893, Pf14259" 29896 ENSG00000164548.10 TRA2A 7 Spliceosome 0 High P52294 Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3 0 17.144 11 4 5 3 538 60.2 5.01 4 1 4 1 2696747.5 2034067.125 753400.125 431493.25 1 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;transporter activity "Pf00514, Pf01749, Pf13513, Pf13646" 3836 ENSG00000114030.12 KPNA1 3 Integration of provirus; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Ribonucleoproteins into the Host Nucleus; Activation of DNA fragmentation factor Influenza A 1 High Q9NS73 MAP3K12-binding inhibitory protein 1 OS=Homo sapiens OX=9606 GN=MBIP PE=1 SV=2 0 13.218 14 3 5 3 344 39.3 7.24 3 2 3 2 8514188.438 1243233.219 3 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;protein binding 51562 ENSG00000151332.18 MBIP 14 HATs acetylate histones 0 High P62304 Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1 0 14.211 52 3 5 3 92 10.8 9.44 1 3 1 4 718481.2813 46612604.8 69143.81836 2 3 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6635 ENSG00000182004.12 SNRPE 1 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome 0 High P16278 Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2 0 14.647 10 5 5 5 677 76 6.57 5 5 1090301.936 137013.4375 4841468.5 2 1 4 metabolic process;response to stimulus;transport cytoplasm;extracellular;Golgi;organelle lumen;vacuole catalytic activity;protein binding "Pf01301, Pf02449, Pf13364" 2720 GLB1 3 Sialic acid metabolism; Neutrophil degranulation; MPS IV - Morquio syndrome B; Glycosphingolipid metabolism; HS-GAG degradation; Keratan sulfate degradation Lysosome; Glycosphingolipid biosynthesis - ganglio series; Galactose metabolism; Glycosaminoglycan degradation; Sphingolipid metabolism; Other glycan degradation; Metabolic pathways 0 High Q9UBL3 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1 0 8.957 10 5 5 5 628 68.7 5.69 1 1 3 1 1 3 12624761.5 712428.9375 2345402 2 1 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf00622 9070 ENSG00000129691.15 ASH2L 8 Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex 0 High O95158 Neurexophilin-4 OS=Homo sapiens OX=9606 GN=NXPH4 PE=2 SV=3 0 12.376 15 4 5 4 308 33 9.86 4 5 127502.5703 7753899.75 1 4 regulation of biological process;response to stimulus extracellular protein binding Pf06312 11247 ENSG00000182379.9 NXPH4 12 0 High Q9Y315 Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2 0 4.956 7 2 5 2 318 35.2 8.94 2 5 1495293.688 1958865.125 2 1 metabolic process;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen catalytic activity Pf01791 51071 ENSG00000023697.12 DERA 12 Neutrophil degranulation; Pentose phosphate pathway (hexose monophosphate shunt) Pentose phosphate pathway 0 High Q9BW92 "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" 0 17.77 8 5 5 5 718 81 7.3 4 1 4 1 8133545.625 551910.7969 4 2 metabolic process;regulation of biological process cytoplasm;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00587, Pf02824, Pf03129, Pf07973" 80222 ENSG00000143374.16 TARS2 1 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q9H9Y2 Ribosome production factor 1 OS=Homo sapiens OX=9606 GN=RPF1 PE=1 SV=2 0 14.039 12 4 5 4 349 40.1 10.01 4 5 537330.75 12790379.5 2114.329102 1 4 1 cell organization and biogenesis;metabolic process nucleus protein binding;RNA binding Pf04427 80135 ENSG00000117133.10 RPF1 1 0 High Q9P206 Uncharacterized protein KIAA1522 OS=Homo sapiens OX=9606 GN=KIAA1522 PE=1 SV=2 0 17.855 7 4 5 4 1035 107 9.73 4 5 237201.3594 4348470 278064.0313 532947.75 1 3 1 1 cell differentiation 57648 ENSG00000162522.10 KIAA1522 1 0 High Q9BXP5 Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1 0 7.527 4 4 5 4 876 100.6 5.96 2 2 1 2 2 1 5400606.5 2184770.656 1415146.969 4 3 4 cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf04959, Pf12066" 51593 ENSG00000087087.18 SRRT 7 RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway 0 High P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3 0 11.816 10 3 5 3 340 37.4 6 3 2 3 2 2072.580322 9812871 2691856.5 4054014.594 1 3 2 3 cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol;membrane catalytic activity;protein binding;signal transducer activity Pf00400 2782 ENSG00000078369.17 GNB1 1 "G alpha (z) signalling events; Activation of G protein gated Potassium channels; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; Olfactory Signaling Pathway; G beta:gamma signalling through PI3Kgamma; Vasopressin regulates renal water homeostasis via Aquaporins; G-protein activation; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; G alpha (12/13) signalling events; Ca2+ pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Glucagon signaling in metabolic regulation; Thrombin signalling through proteinase activated receptors (PARs); Prostacyclin signalling through prostacyclin receptor; Gastrin-CREB signalling pathway via PKC and MAPK; Activation of the phototransduction cascade; Inactivation, recovery and regulation of the phototransduction cascade" Dopaminergic synapse; Serotonergic synapse; Phototransduction; Glutamatergic synapse; Olfactory transduction; Circadian entrainment; Morphine addiction; Pathways in cancer; Retrograde endocannabinoid signaling; GABAergic synapse; Alcoholism; Ras signaling pathway; Chemokine signaling pathway; Cholinergic synapse; PI3K-Akt signaling pathway 0 High Q96T37 RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2 0 19.127 7 5 5 5 977 107.1 10.08 5 5 268102.6875 8874677.125 782693.9277 1 5 4 metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding "Pf00076, Pf07744, Pf13893, Pf14259" 64783 ENSG00000162775.14 RBM15 1 0 High P63151 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1 0 13.148 10 4 5 4 447 51.7 6.2 2 2 1 2 2 1 2490691.188 1694832.039 1577544.201 2 2 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol catalytic activity;enzyme regulator activity;protein binding 5520 ENSG00000221914.9 PPP2R2A 8 Cyclin D associated events in G1; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Initiation of Nuclear Envelope Reformation; Cyclin A/B1/B2 associated events during G2/M transition Dopaminergic synapse; Chagas disease (American trypanosomiasis); Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; mRNA surveillance pathway; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway 0 High P57678 Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2 0 9.077 4 3 5 3 1058 120 6.04 2 1 1 3 1 1 1549246.875 1506714.344 540938.75 377375.375 3 2 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus protein binding 50628 ENSG00000179409.10 GEMIN4 17 snRNP Assembly RNA transport 0 High Q13888 General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1 0 14.53 11 4 5 4 395 44.4 6.76 4 5 976636451.9 1373770.25 2186636.25 4 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf04056, Pf07975, Pf13519" 2966; 728340 ENSG00000145736.14; ENSG00000275045.4; ENSG00000276910.4 GTF2H2; GTF2H2C 5; CHR_HSCHR5_2_CTG1_1; CHR_HSCHR5_1_CTG1_1 Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; RNA Polymerase I Promoter Escape; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; Formation of Incision Complex in GG-NER; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Dual incision in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex Viral carcinogenesis; Basal transcription factors; Nucleotide excision repair 0 High P40227 T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3 0 9.737 13 4 5 4 531 58 6.68 1 2 2 1 2 2 838541.875 8452284.313 1269593.969 1379016.25 1 3 2 3 metabolic process;regulation of biological process cytoplasm;cytosol;membrane nucleotide binding;protein binding;RNA binding "Pf00118, Pf05504" 908 ENSG00000146731.10 CCT6A 7 Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High Q9H329 Band 4.1-like protein 4B OS=Homo sapiens OX=9606 GN=EPB41L4B PE=2 SV=2 0 12.132 3 3 5 2 900 99.7 9.04 3 1 4 1 1404967.453 4764818.25 863441.1875 2 2 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity "Pf00373, Pf08736, Pf09379, Pf09380" 54566 ENSG00000095203.14 EPB41L4B 9 0 High Q7L4I2 Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1 0 8.257 7 3 5 3 434 50.5 11.33 1 3 2 3 803181 1508921 5262630.563 4263009.75 1 1 3 3 protein binding;RNA binding Pf15477 65117 ENSG00000111011.17 RSRC2 12 0 High P61619 Protein transport protein Sec61 subunit alpha isoform 1 OS=Homo sapiens OX=9606 GN=SEC61A1 PE=1 SV=2 0 12.655 4 3 5 3 476 52.2 8.06 1 3 1 4 295740.5938 593745.187 1911282.125 8296776.563 1 3 1 3 cell growth;cell organization and biogenesis;response to stimulus;transport cytosol;endoplasmic reticulum;membrane protein binding "Pf00344, Pf10559" 29927 ENSG00000058262.9 SEC61A1 3 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 High Q8TD19 Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2 0 7.79 6 4 5 4 979 107.1 5.74 4 5 2665844.438 1625943.688 4 2 cell division;cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf00415, Pf07714, Pf13540, Pf14531" 91754 ENSG00000119638.12 NEK9 14 "Activation of NIMA Kinases NEK9, NEK6, NEK7; Nuclear Pore Complex (NPC) Disassembly" 0 High Q08431 Lactadherin OS=Homo sapiens OX=9606 GN=MFGE8 PE=1 SV=3 0 13.856 12 5 5 5 387 43.1 8.15 5 5 807775 17940901 1964447.5 4676050.438 1 2 1 5 0 High Q12816 Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3 0 10.837 3 4 5 3 1431 143.6 9.03 3 1 3 2 929841.8125 4330718.75 563055.625 751063.75 1 3 1 1 regulation of biological process cytoplasm;membrane;nucleus protein binding Pf01454 7216 ENSG00000067445.20 TRO X 0 High O75616 "GTPase Era, mitochondrial OS=Homo sapiens OX=9606 GN=ERAL1 PE=1 SV=2" 0 19.684 15 5 5 5 437 48.3 8.84 5 5 17057098.5 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00350, Pf01926, Pf02421, Pf03193, Pf04548, Pf08477, Pf13521" 26284 ENSG00000132591.11 ERAL1 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q6UWY0 Arylsulfatase K OS=Homo sapiens OX=9606 GN=ARSK PE=1 SV=1 0 11.503 7 4 5 4 536 61.4 8.92 4 5 1601709.563 3260639.375 2 3 metabolic process extracellular;organelle lumen catalytic activity;metal ion binding "Pf00884, Pf01676" 153642 ENSG00000164291.16 ARSK 5 The activation of arylsulfatases; Glycosphingolipid metabolism 0 High Q96EK5 KIF1-binding protein OS=Homo sapiens OX=9606 GN=KIF1BP PE=1 SV=1 0 5.043 2 1 5 1 621 71.8 5.49 1 1 1 3 1 1 656389.3281 376719.375 1640170.199 1 1 1 cell differentiation;development;transport cytoplasm;cytoskeleton;mitochondrion protein binding Pf12309 26128 ENSG00000198954.7 KIAA1279; KIF1BP 10 0 High P30511 "HLA class I histocompatibility antigen, alpha chain F OS=Homo sapiens OX=9606 GN=HLA-F PE=1 SV=3" 0 12.046 10 3 5 1 346 39 5.57 3 5 9600826 1070716.875 1 1 regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;membrane protein binding "Pf00129, Pf07654, Pf08205" 3134 ENSG00000204642.13 HLA-F 6 "Interferon alpha/beta signaling; ER-Phagosome pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation 0 High Q13185 Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4 0 21.776 31 4 5 4 183 20.8 5.33 4 1 4 1 3024337.625 5218828.625 1473293.375 2 3 1 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;membrane;nucleus protein binding "Pf00385, Pf01393" 11335; 90416 ENSG00000122565.18 CBX3; C15orf57; CCDC32 7; 15 RNA Polymerase I Chain Elongation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Transcriptional Regulation by E2F6 0 High Q9NVF7 F-box only protein 28 OS=Homo sapiens OX=9606 GN=FBXO28 PE=1 SV=1 0 12.942 9 3 5 3 368 41.1 9.55 3 5 3056586.25 2886910.422 3545911.5 2 3 3 chromosome protein binding Pf00646 23219 ENSG00000143756.11 FBXO28 1 0 High Q86WX3 Active regulator of SIRT1 OS=Homo sapiens OX=9606 GN=RPS19BP1 PE=1 SV=1 0 20.433 35 3 5 3 136 15.4 10.74 3 5 172480.2344 19869552.38 603650.375 1 3 1 cytosol;nucleus;ribosome protein binding;RNA binding 91582 ENSG00000187051.8 RPS19BP1 22 Regulation of HSF1-mediated heat shock response 0 High Q9BVS4 Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2 0 21.635 18 5 5 5 552 63.2 5.94 5 5 7800129 3822794 843189.125 3 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding "Pf01163, Pf01636, Pf06293, Pf09202" 55781 ENSG00000058729.10 RIOK2 5 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 Medium A0A0B4J1U7 Immunoglobulin heavy variable 6-1 OS=Homo sapiens OX=9606 GN=IGHV6-1 PE=3 SV=1 0.034 1.363 6 1 5 1 121 13.5 9.2 1 1 3 2 657639.5 11831238 10140426 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane protein binding 28385 ENSG00000282745.1; ENSG00000211933.2 IGHV6-1 14; CHR_HSCHR14_3_CTG1 0 High Q9UH99 SUN domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUN2 PE=1 SV=3 0 14.648 9 5 5 5 717 80.3 6.73 3 2 3 2 4118389.875 984167.1563 4 3 cell organization and biogenesis;cellular component movement;regulation of biological process;transport chromosome;endosome;membrane;nucleus protein binding Pf07738 25777 ENSG00000100242.15 SUN2 22 Meiotic synapsis 0 High Q9UKX7 Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2 0 5.153 6 2 5 2 468 50.1 7.06 2 1 1 3 1 1 780314.8438 1584613.313 447982 232358.1406 2 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;nucleus protein binding "Pf00638, Pf08911" 10762 ENSG00000093000.18 NUP50 22 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q9UKS6 Protein kinase C and casein kinase substrate in neurons protein 3 OS=Homo sapiens OX=9606 GN=PACSIN3 PE=1 SV=2 0 19.027 13 4 5 4 424 48.5 6.18 4 5 81142.07031 13361289 386590.0938 1354112.875 1 4 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane enzyme regulator activity;nucleotide binding;protein binding "Pf00018, Pf00611, Pf01025, Pf07653, Pf13514, Pf14604" 29763 ENSG00000165912.15 PACSIN3 11 Clathrin-mediated endocytosis 0 High O43432 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2 0 12.75 3 4 5 2 1585 176.5 5.38 3 1 4 1 2084878.875 8380.848633 1 1 metabolic process;regulation of biological process cytosol protein binding;RNA binding "Pf02020, Pf02847, Pf02854" 8672 ENSG00000075151.20 EIF4G3 1 ISG15 antiviral mechanism RNA transport; Viral myocarditis 0 High Q9NWT8 Aurora kinase A-interacting protein OS=Homo sapiens OX=9606 GN=AURKAIP1 PE=1 SV=1 0.001 3.864 8 2 5 2 199 22.3 10.76 2 5 26963577.44 2 cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion;nucleus;ribosome catalytic activity;protein binding Pf08213 54998 ENSG00000175756.13 AURKAIP1 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q9NRR4 Ribonuclease 3 OS=Homo sapiens OX=9606 GN=DROSHA PE=1 SV=2 0 18.055 3 3 5 3 1374 159.2 7.87 3 5 180896.2031 5673388.5 1460344.375 391692.2432 1 3 2 2 defense response;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00035, Pf00636, Pf14622" 29102 ENSG00000113360.16 DROSHA 5 MicroRNA (miRNA) biogenesis Ribosome biogenesis in eukaryotes; Proteoglycans in cancer 0 High O75475 PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1 0 18.101 12 5 5 5 530 60.1 9.13 5 5 5439767.625 1315922 1036960.938 3 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00855, Pf11467" 11168 ENSG00000164985.14 PSIP1 9 2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles 0 High O00746 "Nucleoside diphosphate kinase, mitochondrial OS=Homo sapiens OX=9606 GN=NME4 PE=1 SV=1" 0 14.151 25 4 5 4 187 20.6 10.29 4 5 90268.04688 12536810.25 529755.6719 756379.5625 1 4 2 1 metabolic process;regulation of biological process;transport membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00334 4833 ENSG00000103202.12 NME4 16 Interconversion of nucleotide di- and triphosphates Purine metabolism; Metabolic pathways; Pyrimidine metabolism 0 High Q9NRM2 Zinc finger protein 277 OS=Homo sapiens OX=9606 GN=ZNF277 PE=1 SV=2 0 14.672 13 5 5 5 450 52.8 5.34 5 5 108451.1563 11736904.75 81940.53906 1 5 1 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding "Pf12171, Pf12756" 11179 ENSG00000198839.9 ZNF277 7 0 Low Q6IQ20 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Homo sapiens OX=9606 GN=NAPEPLD PE=1 SV=2 0.058 1.042 2 1 5 1 393 45.6 6.06 1 1 1 2 1 2 210866.7813 4653447.406 18549270 17425492 1 1 1 1 metabolic process;response to stimulus cytosol;membrane catalytic activity;metal ion binding;protein binding "Pf00753, Pf12706, Pf13483" 222236 ENSG00000161048.11; ENSG00000275723.4 NAPEPLD 7; CHR_HSCHR7_1_CTG4_4 "Signaling by GPCR; Biosynthesis of A2E, implicated in retinal degradation" Retrograde endocannabinoid signaling 0 High Q9NPE3 H/ACA ribonucleoprotein complex subunit 3 OS=Homo sapiens OX=9606 GN=NOP10 PE=1 SV=1 0 22.107 45 3 5 3 64 7.7 9.99 3 5 7615027.125 2 cell organization and biogenesis;metabolic process nucleus protein binding;RNA binding Pf04135 55505 ENSG00000182117.5 NOP10 15 rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q92925 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3 0 8.447 11 4 5 4 531 58.9 9.64 1 1 3 1 1 3 239933.3906 1093690.031 1446862.375 1208866.563 1 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf02201 6603 ENSG00000108604.15 SMARCD2 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q6P1Q9 Methyltransferase-like protein 2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3 0 13.075 14 4 5 2 378 43.4 5.86 3 2 3 2 52734.85156 4587778.438 1735978.406 1 3 3 metabolic process catalytic activity "Pf01209, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847" 55798 ENSG00000165055.15 METTL2B 7 2 High Q4VCS5 Angiomotin OS=Homo sapiens OX=9606 GN=AMOT PE=1 SV=1 0 9.787 5 4 5 4 1084 118 7.64 2 3 2 3 2122211.688 9466686.875 1258759 659188.1445 2 2 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol protein binding;receptor activity Pf12240 154796 ENSG00000126016.15 AMOT X Signaling by Hippo Hippo signaling pathway 0 High O95503 Chromobox protein homolog 6 OS=Homo sapiens OX=9606 GN=CBX6 PE=1 SV=1 0 26.228 24 5 5 4 412 43.9 10.01 5 5 581905.9258 15121513.25 2 4 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus protein binding;RNA binding Pf00385 23466 ENSG00000183741.11 CBX6 22 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence 1 High O60220 Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1 0 22.272 38 3 5 3 97 11 5.16 3 5 14267457.63 3 transport membrane;mitochondrion metal ion binding;protein binding Pf02953 1678 ENSG00000126953.5 TIMM8A X Mitochondrial protein import; Metabolism of proteins 0 High Q9NSB4 "Keratin, type II cuticular Hb2 OS=Homo sapiens OX=9606 GN=KRT82 PE=3 SV=3" 0 5.442 5 3 5 1 513 56.6 6.74 3 1 4 1 23762866 80291808 55679476 1 1 1 cell death cytosol structural molecule activity Pf00038 3888 ENSG00000161850.2 KRT82 12 Formation of the cornified envelope 0 High P52701 DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2 0 14.643 5 4 5 4 1360 152.7 6.9 4 1 4 1 4130218.313 221186.4375 611709.5918 3 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;Golgi;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" 2956 ENSG00000116062.14 MSH6 2 Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Colorectal cancer; Pathways in cancer; Mismatch repair; Platinum drug resistance 0 High Q96MM7 Heparan-sulfate 6-O-sulfotransferase 2 OS=Homo sapiens OX=9606 GN=HS6ST2 PE=2 SV=2 0 10.31 7 5 5 5 605 69.1 9.73 5 5 158895.6563 1802447.5 462153.9375 996037.8438 1 1 1 3 metabolic process membrane catalytic activity Pf03567 90161 ENSG00000171004.18 HS6ST2 X HS-GAG biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 High P62826 GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3 0 6.563 10 2 5 2 216 24.4 7.49 1 2 1 1 2 2 4082208.75 2156382 2 2 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;endosome;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00025, Pf00071, Pf08477" 5901 ENSG00000132341.11 RAN 12 MicroRNA (miRNA) biogenesis; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; HTLV-I infection; RNA transport 0 High Q14493 Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1 0 11.586 15 4 5 4 270 31.3 7.47 4 5 405249.2188 11869601 1 3 metabolic process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding Pf15247 7884 ENSG00000163950.12 SLBP 4 Cleavage of Growing Transcript in the Termination Region ; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA 0 High Q8NBL1 Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1 0 12.107 10 4 5 4 392 46.2 8.72 4 5 1004.028809 3783466.063 5052365.188 1 3 4 development;metabolic process;regulation of biological process endoplasmic reticulum;organelle lumen catalytic activity Pf05686 56983 ENSG00000163389.10 POGLUT1 3 Pre-NOTCH Processing in the Endoplasmic Reticulum Other types of O-glycan biosynthesis 0 High Q9ULW0 Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2 0 18.587 9 5 5 5 747 85.6 9.23 5 5 429407.125 10082082.75 1 4 cell death;cell division;cell organization and biogenesis;cell proliferation;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus nucleotide binding;protein binding "Pf09041, Pf12214" 22974 ENSG00000088325.15 TPX2 20 Regulation of TP53 Activity through Phosphorylation; AURKA Activation by TPX2 0 High P08240 Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2 0 17.087 9 5 5 5 638 69.8 8.95 3 2 3 2 3739138.125 1153514.328 1558569.699 3 3 4 cell organization and biogenesis;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;RNA binding "Pf00448, Pf02881, Pf03308, Pf04086" 6734 ENSG00000182934.11 SRPR; SRPRA 11 XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export 0 High Q10570 Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2 0 17.545 3 4 5 4 1443 160.8 6.4 1 3 1 1 3 1 274639.2813 3568544 1369613.125 161213.3125 2 2 1 1 metabolic process;transport nucleus protein binding;RNA binding "Pf03178, Pf10433" 29894 ENSG00000071894.16 CPSF1 8 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; tRNA processing in the nucleus; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs mRNA surveillance pathway 0 High Q96IZ6 Methyltransferase-like protein 2A OS=Homo sapiens OX=9606 GN=METTL2A PE=1 SV=5 0 10.269 11 3 4 1 378 43.5 6.01 2 2 2 2 307817.7813 1 metabolic process catalytic activity "Pf01209, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847" 339175 ENSG00000087995.15 METTL2A 17 0 High Q14592 Zinc finger protein 460 OS=Homo sapiens OX=9606 GN=ZNF460 PE=1 SV=2 0 20.343 8 3 4 3 562 63.6 7.01 3 4 8837420.625 3 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf13465" 10794 ENSG00000197714.8 ZNF460 19 Generic Transcription Pathway 0 High Q8WVX9 Fatty acyl-CoA reductase 1 OS=Homo sapiens OX=9606 GN=FAR1 PE=1 SV=1 0 12.813 9 4 4 4 515 59.3 9.17 1 3 1 3 2137290.75 3752887.906 3 4 metabolic process membrane;organelle lumen catalytic activity "Pf01370, Pf03015, Pf07993" 84188 ENSG00000197601.12 FAR1 11 Wax biosynthesis Peroxisome 0 High Q5W0B1 RING finger protein 219 OS=Homo sapiens OX=9606 GN=RNF219 PE=1 SV=1 0 5.261 5 3 4 3 726 81.1 5.72 3 1 3 1 1025333.25 1017246.625 838161.5625 754414.625 3 1 2 1 metal ion binding;protein binding "Pf00097, Pf12678, Pf13639, Pf13920, Pf13923" 79596 ENSG00000152193.7 RNF219 13 0 High Q9H8Y5 Ankyrin repeat and zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1 0 15.687 7 4 4 4 726 80.9 8.41 4 4 7365426.188 4 metabolic process;response to stimulus cytoplasm;membrane catalytic activity;metal ion binding;protein binding "Pf00023, Pf12796" 55139 ENSG00000163516.13 ANKZF1 2 0 High Q9UET6 Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2 0 19.832 19 4 4 4 329 36.1 5.69 4 4 332799.4063 9341220.75 1452618.375 790468.8438 1 4 1 2 metabolic process cytoplasm;cytosol catalytic activity "Pf01728, Pf12847" 24140 ENSG00000068438.14 FTSJ1 X tRNA modification in the nucleus and cytosol 0 Medium Q7Z5H4 Vomeronasal type-1 receptor 5 OS=Homo sapiens OX=9606 GN=VN1R5 PE=2 SV=2 0.04 1.225 2 1 4 1 357 40.8 9.2 1 1 1 1 1 2 4441096.5 9212008 6493915 1 1 1 regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity Pf03402 317705 VN1R5 1 0 High Q9HC52 Chromobox protein homolog 8 OS=Homo sapiens OX=9606 GN=CBX8 PE=1 SV=3 0 11.076 12 4 4 3 389 43.4 9.91 4 4 5124578.375 674912.9375 3 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus enzyme regulator activity;protein binding;RNA binding Pf00385 57332 ENSG00000141570.10 CBX8 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins 0 Medium Q8N584 Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=2 SV=2 0.04 1.231 1 1 4 1 583 65.8 6.99 1 1 1 1 1 1 1 1 1914557.659 9471473 2854606 4144018.25 1 1 1 1 protein binding Pf10300 125488 ENSG00000168234.12 TTC39C 18 0 High O43303 Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens OX=9606 GN=CCP110 PE=1 SV=3 0 8.498 4 4 4 4 1012 113.4 8.65 3 1 3 1 5920340.5 3262577.813 849343.6719 1 3 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding 9738 ENSG00000103540.16 CCP110 16 Ub-specific processing proteases; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High O43347 RNA-binding protein Musashi homolog 1 OS=Homo sapiens OX=9606 GN=MSI1 PE=1 SV=1 0 16.679 12 2 4 2 362 39.1 7.85 2 4 257853.0625 2563592.5 1 2 cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 4440 ENSG00000135097.6 MSI1 12 Regulation of expression of SLITs and ROBOs mRNA surveillance pathway 0 High Q96IZ0 PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1 0 19.144 17 4 4 4 340 36.5 5.41 3 1 3 1 3864228.875 4286277.5 555881.6719 2 2 2 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus protein binding;transporter activity "Pf01544, Pf05911, Pf08614" 5074 ENSG00000177425.10 PAWR 12 0 High P09132 Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3 0 20.493 33 3 4 3 144 16.1 9.85 3 4 10517666.75 2874033.016 2540065.313 3 2 2 cell organization and biogenesis;response to stimulus;transport cytoplasm;cytosol protein binding;RNA binding Pf01922 6728 ENSG00000153037.13 SRP19 5 SRP-dependent cotranslational protein targeting to membrane Protein export 0 Medium Q9Y239 Nucleotide-binding oligomerization domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOD1 PE=1 SV=1 0.011 1.84 1 1 4 1 953 107.6 7.11 1 1 3 1 36516863 1404346.5 529087.75 1 1 1 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;nucleotide binding;protein binding "Pf00619, Pf05729" 10392 ENSG00000106100.10 NOD1 7 NOD1/2 Signaling Pathway; Ovarian tumor domain proteases; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Activated TLR4 signalling; Interleukin-1 family signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; activated TAK1 mediates p38 MAPK activation NOD-like receptor signaling pathway; Pertussis; Epithelial cell signaling in Helicobacter pylori infection; Shigellosis 0 High Q9H0U9 Testis-specific Y-encoded-like protein 1 OS=Homo sapiens OX=9606 GN=TSPYL1 PE=1 SV=3 0 26.354 13 3 4 3 437 49.2 5.45 3 4 1540207.25 11685585 3645.607666 25637.15234 1 2 1 1 cell organization and biogenesis nucleus protein binding Pf00956 7259 ENSG00000189241.6 TSPYL1 6 0 High Q9BY12 S phase cyclin A-associated protein in the endoplasmic reticulum OS=Homo sapiens OX=9606 GN=SCAPER PE=1 SV=2 0 12.567 3 4 4 4 1400 158.2 7.44 4 4 48654383.44 8976161.5 395224.0625 245756.6094 2 4 1 1 cytosol;endoplasmic reticulum;nucleus metal ion binding Pf12874 49855 ENSG00000140386.12 SCAPER 15 0 High P53985 Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3 0 8.53 7 2 4 2 500 53.9 8.66 1 2 1 3 174856.8125 1329104.313 3604053.094 1 1 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity "Pf00083, Pf07690, Pf12832" 6566 ENSG00000281917.2; ENSG00000155380.11 SLC16A1 1; CHR_HG2104_PATCH Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT); Basigin interactions; Pyruvate metabolism 0 High P06753 Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2 0 6.759 9 2 4 1 285 32.9 4.72 2 1 3 1 2686091.063 513082.9063 2 1 cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity "Pf00261, Pf12718" 7170 ENSG00000143549.19 TPM3 1 Smooth Muscle Contraction; Striated Muscle Contraction Dilated cardiomyopathy; Pathways in cancer; Adrenergic signaling in cardiomyocytes; Thyroid cancer; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM) 1 High P05165 "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4" 0 8.885 5 3 4 3 728 80 7.52 2 2 2 2 9711.371094 1363950.375 1575564.938 1 2 3 metabolic process cytosol;extracellular;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf01071, Pf02222, Pf02258, Pf02785, Pf02786, Pf07478, Pf08442, Pf08443, Pf13437, Pf13533, Pf13535, Pf13549, Pf15632" 5095 ENSG00000175198.15 PCCA 13 Defective HLCS causes multiple carboxylase deficiency; Biotin transport and metabolism; Propionyl-CoA catabolism "Propanoate metabolism; Carbon metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Valine, leucine and isoleucine degradation" 0 High P41250 Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS PE=1 SV=3 0 4.534 3 3 4 3 739 83.1 7.03 1 3 1 3 2941941.875 594718.375 898215 2544124.125 1 1 1 3 metabolic process cytoplasm;cytosol;extracellular;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00458, Pf00587, Pf03129" 2617 ENSG00000106105.13 GARS 7 Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q9BRJ7 Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1 0 9.572 18 3 4 3 211 23.3 8.91 3 1 3 1 6941700.594 663116.0313 3 2 regulation of biological process nucleus catalytic activity;protein binding;RNA binding 84309 ENSG00000168101.14 NUDT16L1 16 Proteoglycans in cancer 0 High Q5VV52 Zinc finger protein 691 OS=Homo sapiens OX=9606 GN=ZNF691 PE=1 SV=2 0 16.531 13 3 4 3 315 35.8 7.8 3 4 19628596.63 3 0 High O60437 Periplakin OS=Homo sapiens OX=9606 GN=PPL PE=1 SV=4 0.002 3.048 1 2 4 1 1756 204.6 5.6 2 1 1 2 1 1 105913648 308298786.5 236614569.5 1 1 1 cell death;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus protein binding;structural molecule activity Pf04111 5493 ENSG00000118898.15 PPL 16 Butyrophilin (BTN) family interactions; Formation of the cornified envelope 0 High O60884 DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1 0 7.787 8 3 4 3 412 45.7 6.48 2 2 2 2 5651909.5 1667038.625 2738070.875 2 1 2 metabolic process;regulation of biological process;response to stimulus cytosol;membrane enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 10294 ENSG00000069345.11 DNAJA2 16 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 High O60765 Zinc finger protein 354A OS=Homo sapiens OX=9606 GN=ZNF354A PE=1 SV=2 0 7.46 7 3 4 1 605 69.2 9.57 3 4 1010570.063 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 6940 ENSG00000169131.11 ZNF354A 5 Generic Transcription Pathway 0 High Q6UWF9 Protein FAM180A OS=Homo sapiens OX=9606 GN=FAM180A PE=2 SV=1 0.004 2.366 12 1 4 1 173 19.7 8.47 1 4 31015924 4622213.5 2 1 extracellular Pf15173 389558 ENSG00000189320.8 FAM180A 7 0 High P32121 Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2 0 7.64 9 3 4 3 409 46.1 7.69 2 1 1 2 1 1 2211867.75 7800407.625 9490102.938 1 2 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00339, Pf02752" 409 ENSG00000141480.17 ARRB2 17 Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; G alpha (s) signalling events; Signaling by BRAF and RAF fusions; Ub-specific processing proteases; MAP2K and MAPK activation; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Thrombin signalling through proteinase activated receptors (PARs); Paradoxical activation of RAF signaling by kinase inactive BRAF; Activation of SMO; Interleukin-20 family signaling; WNT5A-dependent internalization of FZD4 Dopaminergic synapse; Endocytosis; MAPK signaling pathway; Olfactory transduction; Morphine addiction; Hedgehog signaling pathway; Chemokine signaling pathway 0 High Q7L3T8 "Probable proline--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=PARS2 PE=1 SV=1" 0 17.537 14 4 4 4 475 53.2 8.1 4 4 334674.6523 5875591.063 375586.2813 1630739.75 2 4 1 1 metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00587, Pf03129" 25973 ENSG00000162396.5 PARS2 1 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q14574 Desmocollin-3 OS=Homo sapiens OX=9606 GN=DSC3 PE=1 SV=3 0 5.469 4 3 4 3 896 99.9 6.1 1 2 1 1 2 1 153730.4375 2709195.688 2000496.031 1289349.563 1 3 3 2 cell death;regulation of biological process cytoskeleton;membrane metal ion binding;protein binding "Pf00028, Pf01049, Pf08758" 1825 ENSG00000134762.16 DSC3 18 Formation of the cornified envelope 0 High Q2TB18 Protein asteroid homolog 1 OS=Homo sapiens OX=9606 GN=ASTE1 PE=1 SV=1 0 15.267 8 4 4 4 679 77 8.06 4 4 43906.25781 5141705 10680.60449 1 3 1 metabolic process;response to stimulus catalytic activity;protein binding Pf12813 28990 ENSG00000034533.11 ASTE1 3 0 Medium Q4KWH8 "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" 0.035 1.34 0 1 4 1 1693 189.1 7.74 1 1 1 3 1473786.375 40473971 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;protein binding;signal transducer activity "Pf00036, Pf00168, Pf00387, Pf00388, Pf09279, Pf13499, Pf14788" 23007 ENSG00000114805.16 PLCH1 3 Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism; Metabolic pathways 0 High Q08378 Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2 0 7.728 2 3 4 3 1498 167.3 5.44 3 4 762410 2 metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf01576, Pf02463, Pf04111, Pf05557, Pf07888, Pf10186, Pf12128, Pf12325" 2802 ENSG00000090615.14 GOLGA3 12 0 High Q9UC06 Zinc finger protein 70 OS=Homo sapiens OX=9606 GN=ZNF70 PE=2 SV=2 0 6.366 7 3 4 1 446 50.8 8.31 3 4 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 7621 ENSG00000187792.4 ZNF70 22 Generic Transcription Pathway 0 High Q6ZN17 Protein lin-28 homolog B OS=Homo sapiens OX=9606 GN=LIN28B PE=1 SV=1 0 9.184 15 3 4 3 250 27.1 8.91 3 4 4665925.25 2 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus DNA binding;metal ion binding;protein binding;RNA binding Pf00313 389421 ENSG00000187772.7 LIN28B 6 0 High Q9BZQ6 ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2 0 12.898 5 4 4 4 932 104.6 4.93 4 4 4071891 2753579.375 644514.5 1 2 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding "Pf01532, Pf02225" 80267 ENSG00000116406.18 EDEM3 1 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High P55884 Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3 0 16.224 6 4 4 4 814 92.4 5 4 4 172554.3594 6895721.625 1282144.375 1479727.688 1 4 1 2 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol protein binding;RNA binding;structural molecule activity "Pf00076, Pf08662, Pf13893, Pf14259" 8662 ENSG00000106263.17 EIF3B 7 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High Q9BWE0 Replication initiator 1 OS=Homo sapiens OX=9606 GN=REPIN1 PE=1 SV=1 0 13.497 7 3 4 3 567 63.5 9.98 3 4 12123142.5 870012.4375 1728449.75 2 1 1 metabolic process nucleus DNA binding;metal ion binding;RNA binding "Pf00096, Pf13465" 29803 ENSG00000214022.11 REPIN1 7 0 High Q3SY77 UDP-glucuronosyltransferase 3A2 OS=Homo sapiens OX=9606 GN=UGT3A2 PE=2 SV=1 0 17.595 11 4 4 4 523 59.5 8.31 4 4 243723.7813 1831661.438 1 2 metabolic process;response to stimulus membrane catalytic activity Pf00201 167127 ENSG00000168671.9 UGT3A2 5 Glucuronidation 0 High Q15392 Delta(24)-sterol reductase OS=Homo sapiens OX=9606 GN=DHCR24 PE=1 SV=2 0 7.269 6 2 4 2 516 60.1 8.16 1 2 1 3 1588370.625 2505101.938 1 2 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding Pf01565 1718 ENSG00000116133.11 DHCR24 1 Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol Steroid biosynthesis; Metabolic pathways 0 High Q96EU6 Ribosomal RNA processing protein 36 homolog OS=Homo sapiens OX=9606 GN=RRP36 PE=1 SV=1 0 13.296 15 4 4 4 259 29.8 10.17 4 4 8711775.25 22332048 12151022 4 1 1 metabolic process nucleus RNA binding Pf06102 88745 ENSG00000124541.6 RRP36 6 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q6P087 Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Homo sapiens OX=9606 GN=RPUSD3 PE=1 SV=3 0 20.812 15 4 4 4 351 38.4 10.32 4 4 3766750 958903.3125 2 1 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding Pf00849 285367 ENSG00000156990.14 RPUSD3 3 0 High Q9H8G2 Caspase activity and apoptosis inhibitor 1 OS=Homo sapiens OX=9606 GN=CAAP1 PE=1 SV=2 0 14.996 13 4 4 4 361 38.3 4.72 4 4 5138267.25 732344.625 2 1 cell death Pf15335 79886 ENSG00000120159.11 CAAP1 9 0 High P22314 Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3 0 8.26 4 3 4 3 1058 117.8 5.76 2 1 3 1 8598139 1316416.75 1282121.25 1 2 3 metabolic process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00899, Pf02134, Pf09358, Pf10585" 7317 ENSG00000130985.16 UBA1 X Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation Ubiquitin mediated proteolysis; Parkinson's disease 0 High Q9Y262 Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1 0 14.925 9 4 4 4 564 66.7 6.34 4 4 6226479.625 3 metabolic process cytoplasm;cytosol;membrane protein binding;RNA binding Pf10255 51386 ENSG00000100129.17 EIF3L 22 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" 0 High Q96KQ4 Apoptosis-stimulating of p53 protein 1 OS=Homo sapiens OX=9606 GN=PPP1R13B PE=1 SV=3 0 9.132 4 4 4 3 1090 119.5 6.76 1 1 2 1 1 2 1846490.813 2547214 1659358.813 1491562.375 2 1 2 2 cell death;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding "Pf00018, Pf00023, Pf07653, Pf10498, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604" 23368 ENSG00000088808.16 PPP1R13B 14 Regulation of TP53 Activity through Association with Co-factors; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation of PUMA and translocation to mitochondria 0 High P68400 Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1 0 7.546 9 2 4 2 391 45.1 7.74 2 2 2 2 654177.6875 2034429.625 1187476.75 1 2 2 cell communication;cell death;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714" 1457 ENSG00000101266.17 CSNK2A1 20 WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation Tight junction; Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Wnt signaling pathway; Adherens junction; Measles; Herpes simplex infection 0 High O43309 Zinc finger and SCAN domain-containing protein 12 OS=Homo sapiens OX=9606 GN=ZSCAN12 PE=1 SV=1 0 7.437 4 2 4 1 604 70.2 6.74 2 1 3 1 2431998.5 331955.0938 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf02023, Pf13465" 9753 ENSG00000158691.14 ZSCAN12 6 0 High Q9NXV2 BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1 0 7.233 11 2 4 2 234 26.1 6.24 1 1 2 2 3768263.5 6585048.75 5927762.625 1 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus protein binding Pf02214 54442 ENSG00000167977.8 KCTD5 16 0 High Q9NRX2 "39S ribosomal protein L17, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" 0 5.168 9 2 4 2 175 20 10.11 2 1 1 2 1 1 1251164.906 8497684.625 2048013.125 1286832.313 2 2 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;structural molecule activity Pf01196 63875 ENSG00000158042.8 MRPL17 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9UKM9 RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1 0 11.186 13 3 4 3 306 32.4 9.17 3 4 8497451.875 3 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 22913 ENSG00000125970.11 RALY 20 0 High Q15637 Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4 0 12.079 10 4 4 4 639 68.3 8.98 1 3 1 3 966094.3438 20560670.88 1130890.25 2018180.438 2 4 1 2 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process nucleus;ribosome;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf00013, Pf00098, Pf13014" 7536 ENSG00000168066.20 SF1 11 mRNA Splicing - Major Pathway 0 High P07737 Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2 0 6.33 16 2 4 2 140 15 8.27 2 1 3 1 29873926 3369822.688 583709.3125 1 2 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus enzyme regulator activity;nucleotide binding;protein binding;RNA binding Pf00235 5216 ENSG00000108518.7 PFN1 17 Platelet degranulation ; Signaling by ROBO receptors; RHO GTPases Activate Formins; PCP/CE pathway Rap1 signaling pathway; Salmonella infection; Regulation of actin cytoskeleton; Shigellosis 0 High P47756 F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4 0 7.798 17 3 4 3 277 31.3 5.59 1 2 1 1 2 1 638272.1875 16825950 3189289.188 448755.0625 1 1 2 1 cell organization and biogenesis;cellular component movement;coagulation;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol protein binding Pf01115 832 ENSG00000077549.17 CAPZB 1 COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Factors involved in megakaryocyte development and platelet production Endocytosis 0 High P30101 Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4 0 5.392 6 3 4 3 505 56.7 6.35 2 2 2 2 4485.128418 5859498.25 2273554.625 1806652.75 1 2 2 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 2923 ENSG00000167004.12 PDIA3 15 "ER-Phagosome pathway; Calnexin/calreticulin cycle; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Protein processing in endoplasmic reticulum; Antigen processing and presentation 0 High Q9H4H8 Protein FAM83D OS=Homo sapiens OX=9606 GN=FAM83D PE=1 SV=3 0 19.247 10 3 4 3 585 64.4 6.54 3 4 3296781.5 2 Met-loss+Acetyl [N-Term] cell division;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process cytoplasm;cytoskeleton protein binding "Pf07894, Pf13091" 81610 ENSG00000101447.14 FAM83D 20 0 High Q9H307 Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5 0 14.144 7 4 4 4 717 81.6 7.14 1 1 2 1 1 2 240625.9063 1423815.75 5247154.984 4358974 1 1 3 2 0 Medium P48995 Short transient receptor potential channel 1 OS=Homo sapiens OX=9606 GN=TRPC1 PE=1 SV=1 0.013 1.804 1 1 4 1 793 91.2 8.05 1 1 3 1 191421056 9403835 3475775.5 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport membrane protein binding;transporter activity "Pf00520, Pf08344, Pf12796, Pf13637" 7220 ENSG00000144935.14 TRPC1 3 Ion homeostasis; Role of second messengers in netrin-1 signaling; TRP channels; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Serotonergic synapse; Glutamatergic synapse; Pancreatic secretion; Axon guidance 0 High P13995 "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" 0 19.408 9 2 4 2 350 37.9 8.73 2 1 3 1 1035541.5 301261540.5 623006.4375 2290408.438 1 2 1 2 metabolic process cytosol;mitochondrion;organelle lumen catalytic activity;metal ion binding "Pf00763, Pf02882" 10797 ENSG00000065911.11 MTHFD2 2 Metabolism of folate and pterines One carbon pool by folate; Metabolic pathways 0 High Q8IXM3 "39S ribosomal protein L41, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" 0 8.998 23 3 4 3 137 15.4 9.57 3 4 4095307 30907012 16403.41992 5504.260742 1 3 1 1 cell death;cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf09809 64975 ENSG00000182154.7 MRPL41 9 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q7Z4Q2 HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2 0 15.951 8 4 4 4 680 74.5 5.11 4 4 148500.5781 17069779.44 39117.86719 10740.10742 1 3 1 1 transport protein binding Pf13513 55027 ENSG00000155393.12 HEATR3 16 0 High P24534 Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3 0 7.227 12 2 4 2 225 24.7 4.67 2 1 1 2 1 1 6664934.625 3528471.75 1556875 2 1 2 metabolic process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus protein binding;RNA binding "Pf00736, Pf14497" 1933 ENSG00000283391.1; ENSG00000114942.13 EEF1B2 2; CHR_HSCHR2_6_CTG7_2 Eukaryotic Translation Elongation 0 High Q14671 Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3 0 7.148 3 4 4 4 1186 126.4 6.84 3 1 3 1 9850336.313 686534.125 421182.4063 3 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding;RNA binding Pf00806 9698 ENSG00000134644.15 PUM1 1 Golgi Associated Vesicle Biogenesis 0 High Q96LW1 Zinc finger protein 354B OS=Homo sapiens OX=9606 GN=ZNF354B PE=1 SV=1 0 6.748 7 3 4 1 612 70.5 9.5 3 4 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 117608 ENSG00000178338.10 ZNF354B 5 Generic Transcription Pathway 0 High Q68CQ4 Digestive organ expansion factor homolog OS=Homo sapiens OX=9606 GN=DIEXF PE=1 SV=2 0 8.833 6 4 4 4 756 87 5.88 4 4 8193837.75 325388.7188 636130.625 3 1 1 development;metabolic process nucleus protein binding;RNA binding Pf06862 27042 ENSG00000117597.17 DIEXF 1 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High P49406 "39S ribosomal protein L19, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" 0 8.993 9 3 4 3 292 33.5 9.5 3 4 1009633.734 7662427.25 2 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus;ribosome structural molecule activity Pf01245 9801 ENSG00000115364.13 MRPL19 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P25490 Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2 0 10.184 11 4 4 4 414 44.7 6.25 4 4 4348082.844 1077230.625 3 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00096, Pf13465" 7528 ENSG00000100811.12 YY1 14 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; UCH proteinases; DNA Damage Recognition in GG-NER; Activation of anterior HOX genes in hindbrain development during early embryogenesis 0 High O94776 Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1 0 13.008 6 4 4 4 668 75 9.66 4 4 4227450.25 3 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00249, Pf00320, Pf01426, Pf01448" 9219 ENSG00000149480.6 MTA2 11 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation 0 High Q6P5R6 60S ribosomal protein L22-like 1 OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2 0 16.544 46 4 4 3 122 14.6 9.38 4 4 1982784.25 30748833 1727267.5 4397256.5 1 3 1 1 metabolic process ribosome RNA binding;structural molecule activity Pf01776 200916 ENSG00000163584.17 RPL22L1 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q92791 Endoplasmic reticulum protein SC65 OS=Homo sapiens OX=9606 GN=P3H4 PE=1 SV=1 0 6.036 10 4 4 4 437 50.3 4.77 1 3 1 3 6551369.5 16102594 25852108.06 1 1 3 cell organization and biogenesis;metabolic process chromosome;endoplasmic reticulum protein binding 10609 ENSG00000141696.12 LEPREL4; P3H4 17 0 High Q16625 Occludin OS=Homo sapiens OX=9606 GN=OCLN PE=1 SV=1 0 6.813 8 3 4 3 522 59.1 6.09 2 2 2 2 2200686.375 2126100.625 2 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;motor activity;protein binding "Pf01284, Pf01576, Pf03962, Pf04111, Pf04156, Pf06653, Pf07303, Pf12325, Pf13536, Pf13863, Pf13962" 100506658 ENSG00000197822.10 OCLN 5 Apoptotic cleavage of cell adhesion proteins; RUNX1 regulates expression of components of tight junctions Tight junction; Pathogenic Escherichia coli infection; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Hepatitis C 0 High P62875 "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" 0 5.938 30 2 4 2 67 7.6 7.77 1 1 1 1 1 1 1 1 253258.3906 10807492 1032708.313 552236.25 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf01194 5441 ENSG00000177700.5 POLR2L 11 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q9Y5V3 Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3 0 14.412 9 3 4 3 778 86.1 5.83 1 1 2 1 1 2 2680074.5 2806701 3776666.688 2 3 2 regulation of biological process chromosome;cytoplasm;membrane;nucleus protein binding "Pf00874, Pf01454" 9500 ENSG00000179222.17 MAGED1 X Ligand-independent caspase activation via DCC; NRAGE signals death through JNK; Signalling by NGF Neurotrophin signaling pathway 0 High Q96LT9 RNA-binding region-containing protein 3 OS=Homo sapiens OX=9606 GN=RNPC3 PE=1 SV=1 0 8.656 8 3 4 3 517 58.5 7.72 3 4 5201056.281 3 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 55599 ENSG00000185946.15 RNPC3 1 mRNA Splicing - Minor Pathway 0 High Q9NSD9 Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3 0 8.927 5 3 4 3 589 66.1 6.84 3 4 1872864.125 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf03483, Pf03484" 10056 ENSG00000116120.9 FARSB 2 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High O14980 Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1 0 11.642 4 4 4 4 1071 123.3 6.06 1 3 1 3 197046.0625 1215277.813 1276421.906 2317613.844 1 2 3 4 cell organization and biogenesis;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;transporter activity "Pf03810, Pf08389, Pf08767" 7514 ENSG00000082898.16 XPO1 2 Rev-mediated nuclear export of HIV RNA; Downregulation of TGF-beta receptor signaling; NEP/NS2 Interacts with the Cellular Export Machinery; Cyclin A/B1/B2 associated events during G2/M transition; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deactivation of the beta-catenin transactivating complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HuR (ELAVL1) binds and stabilizes mRNA; RHO GTPases Activate Formins; MAPK6/MAPK4 signaling Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; HTLV-I infection; RNA transport; Influenza A 0 High O43295 SLIT-ROBO Rho GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=SRGAP3 PE=1 SV=3 0 8.364 3 4 4 4 1099 124.4 6.68 2 2 2 2 335572647.1 2624265 1143580.594 2 3 3 regulation of biological process;response to stimulus cytoplasm;cytosol enzyme regulator activity;protein binding "Pf00018, Pf00611, Pf00620, Pf07653, Pf14604" 9901 ENSG00000196220.15 SRGAP3 3 Inactivation of CDC42 and RAC1; Rho GTPase cycle Axon guidance 0 High Q00535 Cyclin-dependent-like kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3 0 5.448 9 3 4 2 292 33.3 7.66 1 2 1 1 2 1 902908.625 1327046.75 526033.625 723427.125 1 1 1 2 cell communication;cell death;cell differentiation;cell division;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1020 ENSG00000164885.12 CDK5 7 Signaling by GPCR; DARPP-32 events; CRMPs in Sema3A signaling; Regulation of TP53 Activity through Phosphorylation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Factors involved in megakaryocyte development and platelet production Alzheimer's disease; Cocaine addiction; Axon guidance 0 High O95059 Ribonuclease P protein subunit p14 OS=Homo sapiens OX=9606 GN=RPP14 PE=1 SV=3 0 25.791 40 3 4 3 124 13.7 7.75 3 4 599619.25 2476910.938 61630.22266 1 2 1 metabolic process nucleus catalytic activity;RNA binding Pf01900 11102 ENSG00000163684.11 RPP14 3 Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus RNA transport 0 High Q8N4V1 Membrane magnesium transporter 1 OS=Homo sapiens OX=9606 GN=MMGT1 PE=1 SV=1 0 4.982 18 1 4 1 131 14.7 9.16 1 1 2 2 2520272.813 893776 1 1 transport endoplasmic reticulum;endosome;Golgi;membrane transporter activity Pf10270 93380 ENSG00000169446.5 MMGT1 X Miscellaneous transport and binding events 0 High Q6P1M0 Long-chain fatty acid transport protein 4 OS=Homo sapiens OX=9606 GN=SLC27A4 PE=1 SV=1 0 10.265 7 4 4 4 643 72 8.47 4 4 1229975.313 1664365.75 2 2 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;transporter activity "Pf00501, Pf13193" 10999 ENSG00000167114.12 SLC27A4 9 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS); Transport of fatty acids Fat digestion and absorption; PPAR signaling pathway; Insulin resistance 0 High Q86V48 Leucine zipper protein 1 OS=Homo sapiens OX=9606 GN=LUZP1 PE=1 SV=2 0 10.531 5 4 4 4 1076 120.2 8.5 4 4 3662222.063 2 metabolic process membrane;nucleus Pf04111 7798 ENSG00000169641.13 LUZP1 1 0 High Q13889 General transcription factor IIH subunit 3 OS=Homo sapiens OX=9606 GN=GTF2H3 PE=1 SV=2 0 13.854 15 3 4 3 308 34.4 7.02 3 4 1452864.5 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding Pf03850 2967 ENSG00000111358.13 GTF2H3 12 Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; RNA Polymerase I Promoter Escape; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; Formation of Incision Complex in GG-NER; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Dual incision in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex Viral carcinogenesis; Basal transcription factors; Nucleotide excision repair 0 High P49770 Translation initiation factor eIF-2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3 0 8.503 10 3 4 3 351 39 6.16 3 4 361136.4688 6319806.125 582566.0625 1 3 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol nucleotide binding;protein binding;RNA binding Pf01008 8892 ENSG00000119718.10 EIF2B2 14 Recycling of eIF2:GDP RNA transport 0 High P28482 Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3 0 10.717 10 3 4 3 360 41.4 6.98 2 1 2 2 1561208.625 534938.375 6438210.906 1 1 2 cell communication;cell death;cell differentiation;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;extracellular;Golgi;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf01636, Pf07714" 5594 ENSG00000100030.14 MAPK1 22 "phospho-PLA2 pathway; NCAM signaling for neurite out-growth; Activated TLR4 signalling; Negative feedback regulation of MAPK pathway; RUNX2 regulates osteoblast differentiation; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Signaling by BRAF and RAF fusions; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; RSK activation; ERKs are inactivated; MAP2K and MAPK activation; FCERI mediated MAPK activation; Signaling by GPCR; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signal attenuation; Activation of the AP-1 family of transcription factors; Golgi Cisternae Pericentriolar Stack Reorganization; MAPK1 (ERK2) activation; Interleukin-20 family signaling; Spry regulation of FGF signaling; Signal transduction by L1; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of HSF1-mediated heat shock response; Advanced glycosylation endproduct receptor signaling; Recycling pathway of L1; Thrombin signalling through proteinase activated receptors (PARs); Gastrin-CREB signalling pathway via PKC and MAPK; Regulation of PTEN gene transcription; RHO GTPases Activate WASPs and WAVEs; Oncogene Induced Senescence; Growth hormone receptor signaling; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence" Viral carcinogenesis; Chagas disease (American trypanosomiasis); Serotonergic synapse; Th1 and Th2 cell differentiation; TGF-beta signaling pathway; T cell receptor signaling pathway; Dorso-ventral axis formation; TNF signaling pathway; NOD-like receptor signaling pathway; Osteoclast differentiation; Prion diseases; Vascular smooth muscle contraction; Glutamatergic synapse; Hepatitis B; Insulin signaling pathway; HIF-1 signaling pathway; Central carbon metabolism in cancer; Pancreatic cancer; FoxO signaling pathway; Prolactin signaling pathway; MicroRNAs in cancer; Phospholipase D signaling pathway; cGMP-PKG signaling pathway; Chronic myeloid leukemia; Neurotrophin signaling pathway; B cell receptor signaling pathway; VEGF signaling pathway; Leishmaniasis; Acute myeloid leukemia; Rap1 signaling pathway; Non-small cell lung cancer; Progesterone-mediated oocyte maturation; MAPK signaling pathway; Oxytocin signaling pathway; Circadian entrainment; Endometrial cancer; Breast cancer; Colorectal cancer; Type II diabetes mellitus; Natural killer cell mediated cytotoxicity; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Long-term potentiation; Thyroid hormone signaling pathway; Glioma; Gap junction; Adrenergic signaling in cardiomyocytes; AGE-RAGE signaling pathway in diabetic complications; Renal cell carcinoma; Tuberculosis; Pertussis; Melanoma; EGFR tyrosine kinase inhibitor resistance; Toxoplasmosis; Apoptosis; Melanogenesis; Focal adhesion; Proteoglycans in cancer; Choline metabolism in cancer; Alzheimer's disease; mTOR signaling pathway; Aldosterone-regulated sodium reabsorption; Salmonella infection; Adherens junction; Long-term depression; Regulation of actin cytoskeleton; Retrograde endocannabinoid signaling; Oocyte meiosis; Sphingolipid signaling pathway; Toll-like receptor signaling pathway; Bladder cancer; Fc epsilon RI signaling pathway; Thyroid cancer; Hepatitis C; Alcoholism; Ras signaling pathway; Fc gamma R-mediated phagocytosis; Endocrine resistance; GnRH signaling pathway; Chemokine signaling pathway; Axon guidance; Signaling pathways regulating pluripotency of stem cells; cAMP signaling pathway; Influenza A; Estrogen signaling pathway; Cholinergic synapse; PI3K-Akt signaling pathway; Platelet activation; Shigellosis; Platinum drug resistance 0 High Q96PM9 Zinc finger protein 385A OS=Homo sapiens OX=9606 GN=ZNF385A PE=1 SV=2 0 14.045 11 3 4 3 386 40.4 9.86 3 4 6864585.25 58171320 115854912 3 1 1 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf07535, Pf12171, Pf12874" 25946 ENSG00000161642.17 ZNF385A 12 Regulation of TP53 Activity through Association with Co-factors; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Transcriptional activation of cell cycle inhibitor p21 0 High P30532 Neuronal acetylcholine receptor subunit alpha-5 OS=Homo sapiens OX=9606 GN=CHRNA5 PE=1 SV=2 0 6.847 10 4 4 4 468 53 6.98 4 4 1021270.563 204052.375 2667596.25 1 1 3 cell communication;regulation of biological process;response to stimulus;transport membrane protein binding;receptor activity;signal transducer activity;transporter activity "Pf02931, Pf02932" 1138 ENSG00000169684.13 CHRNA5 15 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors; Highly calcium permeable nicotinic acetylcholine receptors Neuroactive ligand-receptor interaction 0 High P46109 Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1 0 8.461 11 4 4 4 303 33.8 6.74 1 3 1 3 3338348.25 1656284.188 972984.1875 1 2 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome protein binding;RNA binding;signal transducer activity "Pf00017, Pf00018, Pf07653, Pf14604" 1399 ENSG00000099942.12 CRKL 22 MET receptor recycling; Frs2-mediated activation; Regulation of signaling by CBL; MET activates RAP1 and RAC1; Downstream signal transduction Insulin signaling pathway; MicroRNAs in cancer; Chronic myeloid leukemia; Neurotrophin signaling pathway; Rap1 signaling pathway; MAPK signaling pathway; ErbB signaling pathway; Pathways in cancer; Renal cell carcinoma; Focal adhesion; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Fc gamma R-mediated phagocytosis; Chemokine signaling pathway; Shigellosis 0 High Q9H4M3 F-box only protein 44 OS=Homo sapiens OX=9606 GN=FBXO44 PE=1 SV=3 0 8.792 18 4 4 4 255 29.7 5.82 3 1 3 1 587503.0625 1869193.875 896335.3926 1 3 4 Met-loss [N-Term] metabolic process cytosol catalytic activity;protein binding "Pf00646, Pf04300, Pf12937" 93611 ENSG00000132879.13 FBXO44 1 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q8N163 Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2 0 5.323 5 2 4 2 923 102.8 5.22 2 1 3 1 326409.2813 2968282.5 430149.25 351277.6563 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;organelle lumen;spliceosomal complex enzyme regulator activity;protein binding;RNA binding "Pf14443, Pf14444" 57805 ENSG00000158941.16 CCAR2; KIAA1967 8 Regulation of HSF1-mediated heat shock response 0 High O43657 Tetraspanin-6 OS=Homo sapiens OX=9606 GN=TSPAN6 PE=1 SV=1 0 9.217 16 2 4 2 245 27.5 8.1 2 4 3909447 2 regulation of biological process;response to stimulus membrane protein binding;signal transducer activity Pf00335 7105 ENSG00000000003.14 TSPAN6 X 0 High Q8TED9 Actin filament-associated protein 1-like 1 OS=Homo sapiens OX=9606 GN=AFAP1L1 PE=1 SV=2 0 7.853 8 4 4 4 768 86.4 6.8 2 2 2 2 1169136.063 523526.0625 903377.4063 2 1 2 cytoplasm protein binding Pf00169 134265 ENSG00000157510.13 AFAP1L1 5 0 High P52298 Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1 0.007 1.985 4 1 4 1 156 18 8.21 1 1 1 1 2 1 124450.0625 4857240.563 639750 274713.6875 1 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 22916 ENSG00000114503.10 NCBP2 3 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; SLBP independent Processing of Histone Pre-mRNAs; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; snRNP Assembly; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; mRNA 3'-end processing; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mRNA Capping; Regulation of expression of SLITs and ROBOs; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Formation of the Early Elongation Complex Spliceosome; mRNA surveillance pathway; RNA transport 0 High P18031 Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1 0 6.469 9 4 4 4 435 49.9 6.27 2 2 2 2 1937893 275789.9063 1 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane catalytic activity;metal ion binding;protein binding;RNA binding "Pf00102, Pf00782" 5770 ENSG00000196396.9 PTPN1 20 Regulation of IFNA signaling; Negative regulation of MET activity; Regulation of IFNG signaling; PTK6 Down-Regulation; Integrin alphaIIb beta3 signaling; Growth hormone receptor signaling Insulin signaling pathway; Adherens junction; Insulin resistance 0 High Q99873 Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3 0 9.982 12 4 4 4 371 42.4 5.35 1 2 1 1 2 1 391940.4375 5584665.75 299633.5625 1 2 1 0 High Q96AY3 Peptidyl-prolyl cis-trans isomerase FKBP10 OS=Homo sapiens OX=9606 GN=FKBP10 PE=1 SV=1 0 6.794 5 3 4 3 582 64.2 5.62 1 3 1 3 986484.1563 2008454 2 2 cell organization and biogenesis;metabolic process cytoplasm;endoplasmic reticulum;organelle lumen catalytic activity;metal ion binding Pf00254 60681 ENSG00000141756.18 FKBP10 17 0 High P60468 Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2 0 8.343 27 2 4 2 96 10 11.56 2 1 3 1 6731494.5 810228.125 567714.0625 2 1 1 Met-loss [N-Term] metabolic process;transport cytosol;endoplasmic reticulum;membrane protein binding;RNA binding;transporter activity Pf03911 10952 ENSG00000106803.9 SEC61B 9 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 High P07195 L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2 0 8.423 10 3 4 3 334 36.6 6.05 1 3 1 3 2262745.5 7017354 1860510.75 1 3 2 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00056, Pf02866" 3945 ENSG00000111716.12 LDHB 12 Pyruvate metabolism Propanoate metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways; Cysteine and methionine metabolism 0 High Q9NWB6 Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1 0.001 3.414 5 2 4 2 273 33.2 10.35 1 1 1 1 2 1 932877.8125 1940575.063 2091386.625 1495779.5 1 2 1 1 metabolic process;regulation of biological process mitochondrion;nucleus protein binding Pf15346 55082 ENSG00000134884.13 ARGLU1 13 0 High Q3MHD2 Protein LSM12 homolog OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2 0 19.034 26 3 4 3 195 21.7 7.74 3 4 921514.9375 19964565 528004.125 1147579.5 1 2 1 1 Pf09793 124801; 653122 ENSG00000161654.9 LSM12; LSM12P1 17; 8 0 High O00165 HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2 0 8.084 11 3 4 3 279 31.6 4.92 2 2 2 2 3146748.25 1196956.656 1289466.453 1 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;mitochondrion;nucleus protein binding 10456 ENSG00000143575.14 HAX1 1 0 High Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2 0 8.058 6 3 4 3 626 72.2 7.14 2 2 2 2 2093950.625 1082737.5 1952307.164 3 2 3 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00536, Pf01966, Pf07647" 25939 ENSG00000101347.8 SAMHD1 20 Nucleobase catabolism; Interferon alpha/beta signaling 0 High Q9NX20 "39S ribosomal protein L16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL16 PE=1 SV=1" 0 16.433 18 4 4 4 251 28.4 10.13 4 4 2985539.5 13985005.25 56460.42969 10945.56152 1 4 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00252 54948 ENSG00000166902.4 MRPL16 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P51688 N-sulphoglucosamine sulphohydrolase OS=Homo sapiens OX=9606 GN=SGSH PE=1 SV=1 0 6.718 5 2 4 2 502 56.7 6.95 1 2 1 3 744259.25 4438760.75 1 2 metabolic process organelle lumen;vacuole catalytic activity;metal ion binding "Pf00884, Pf01663" 6448 ENSG00000181523.12 SGSH 17 HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A Lysosome; Glycosaminoglycan degradation; Metabolic pathways 0 High Q8IY18 Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2 0 17.6 5 4 4 4 1101 128.7 8.38 4 4 4726268.5 47846.90234 6833.070313 3 1 1 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus nucleotide binding;protein binding "Pf02463, Pf05667, Pf06785, Pf08614, Pf13166, Pf13304, Pf13476, Pf13851" 23137 ENSG00000198887.8 SMC5 9 SUMOylation of DNA damage response and repair proteins 0 High P18887 DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=2 0 8.451 9 3 4 3 633 69.4 6.39 1 2 1 3 316719616 1489725 1005717.063 1 1 2 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding "Pf00533, Pf01834, Pf12738" 7515 XRCC1 19 Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER Base excision repair 0 High Q13901 Nuclear nucleic acid-binding protein C1D OS=Homo sapiens OX=9606 GN=C1D PE=1 SV=1 0 13.906 46 3 4 3 141 16 9.03 2 1 3 1 1205598.625 761609.75 160260.9219 3 1 1 Met-loss+Acetyl [N-Term] cell death;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding Pf04000 10438 ENSG00000197223.11 C1D 2 Major pathway of rRNA processing in the nucleolus and cytosol RNA degradation 0 High P25786 Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1 0 6.175 11 3 4 3 263 29.5 6.61 2 2 2 2 2866540.188 2572370.813 3 3 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;protein binding;RNA binding "Pf00227, Pf10584" 5682 ENSG00000129084.17 PSMA1 11 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q5T653 "39S ribosomal protein L2, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2" 0 10.997 13 4 4 4 305 33.3 11.3 4 4 8921123.75 1968746.188 975035.875 4 2 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome catalytic activity;RNA binding;structural molecule activity "Pf00181, Pf03947" 51069 ENSG00000112651.11 MRPL2 6 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9NWH9 SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2 0 16.303 2 2 4 2 1034 117.1 7.87 2 1 1 2 1 1 272318.375 5635945.625 966600.9063 355760.9375 1 2 1 1 Met-loss+Acetyl [N-Term] cell death;metabolic process;regulation of biological process nucleus DNA binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 79811 ENSG00000137776.16 SLTM 15 0 High Q8TAD8 Smad nuclear-interacting protein 1 OS=Homo sapiens OX=9606 GN=SNIP1 PE=1 SV=1 0 15.813 17 4 4 4 396 45.8 9.99 4 4 44826676.5 3 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding;RNA binding Pf00498 79753 ENSG00000163877.10 SNIP1 1 0 High Q8NCH0 Carbohydrate sulfotransferase 14 OS=Homo sapiens OX=9606 GN=CHST14 PE=1 SV=2 0 6.198 7 3 4 3 376 43 9.48 3 4 289184.7813 1562461.375 1865709.188 1 1 2 metabolic process Golgi;membrane catalytic activity Pf03567 113189 ENSG00000169105.7 CHST14 15 "Defective CHST14 causes EDS, musculocontractural type; Dermatan sulfate biosynthesis" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High O60716 Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1 0 12.233 5 3 4 3 968 108.1 6.23 1 1 2 1 1 2 178798.3594 1048573.25 651830.3125 1189563.52 1 1 1 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus protein binding Pf00514 1500 ENSG00000198561.13 CTNND1 11 VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells Rap1 signaling pathway; Adherens junction; Leukocyte transendothelial migration 0 High Q92664 Transcription factor IIIA OS=Homo sapiens OX=9606 GN=GTF3A PE=1 SV=3 0 12.972 14 2 4 2 365 41.5 9.14 2 4 2071508.344 338662.7188 2 1 Acetyl [N-Term] metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;RNA binding 2971 ENSG00000122034.14 GTF3A 13 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter 0 High Q9NRL2 Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2 0 12.918 3 4 4 4 1556 178.6 6.6 4 4 205625.0625 7902502.25 7586.454102 48515.16406 1 4 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;metal ion binding;protein binding "Pf00439, Pf00628, Pf02791, Pf10537, Pf15612, Pf15614" 11177 ENSG00000198604.10 BAZ1A 14 0 High Q9NT22 EMILIN-3 OS=Homo sapiens OX=9606 GN=EMILIN3 PE=1 SV=2 0 16.088 9 4 4 4 766 82.6 7.72 4 4 2794354.938 414806.0156 3 2 cell organization and biogenesis cytoplasm;cytoskeleton;extracellular protein binding "Pf06160, Pf07546" 90187 ENSG00000183798.4 EMILIN3 20 Molecules associated with elastic fibres 0 High P0CJ79 Zinc finger protein 888 OS=Homo sapiens OX=9606 GN=ZNF888 PE=3 SV=2 0 7.687 5 3 4 1 718 83.5 9.16 3 4 1326814.5 6725188.375 33672.31641 1 2 1 Met-loss+Acetyl [N-Term] 1 High P53582 Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2 0 11.544 22 4 4 4 386 43.2 7.17 4 4 11157106.75 22862480 542087.9375 2 1 1 metabolic process;regulation of biological process cytoplasm;cytosol catalytic activity;metal ion binding Pf00557 23173 ENSG00000164024.11 METAP1 4 "Signaling by GPCR; Inactivation, recovery and regulation of the phototransduction cascade" 0 High Q9BYD6 "39S ribosomal protein L1, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" 0 13.226 15 4 4 4 325 36.9 8.78 4 4 9589265.25 7833405 6720735.5 3 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity "Pf00687, Pf13003" 65008 ENSG00000169288.17 MRPL1 4 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q8N3J9 Zinc finger protein 664 OS=Homo sapiens OX=9606 GN=ZNF664 PE=1 SV=1 0 9.982 23 4 4 2 261 30.3 8.69 4 4 5031527.5 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 144348 ENSG00000179195.15 ZNF664 12 Generic Transcription Pathway 1 High Q8N3Z6 Zinc finger CCHC domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ZCCHC7 PE=1 SV=2 0 15.042 8 4 4 4 543 63 7.33 4 4 10074688.38 146827.3906 4 1 cytosol;nucleus metal ion binding;protein binding;RNA binding 84186 ENSG00000147905.17 ZCCHC7 9 RNA degradation 0 High P61326 Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1 0 8.372 26 3 4 3 146 17.2 6.11 3 4 1284566.375 9394448.75 1 3 metabolic process;regulation of biological process;transport cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding Pf02792 4116 ENSG00000162385.10 MAGOH 1 mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Spliceosome; mRNA surveillance pathway; RNA transport 0 High Q9UHA3 Probable ribosome biogenesis protein RLP24 OS=Homo sapiens OX=9606 GN=RSL24D1 PE=1 SV=1 0 12.844 18 2 4 2 163 19.6 9.98 2 4 72486.40625 13065886.63 1 2 cell organization and biogenesis;metabolic process nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01246 51187 ENSG00000137876.9 RSL24D1 15 Ribosome 0 High Q03113 Guanine nucleotide-binding protein subunit alpha-12 OS=Homo sapiens OX=9606 GN=GNA12 PE=1 SV=4 0.001 3.654 3 1 4 1 381 44.3 9.83 1 1 2 2 4393025.438 2548072.5 1 1 cell differentiation;coagulation;regulation of biological process;response to stimulus cytoplasm;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503" 2768 ENSG00000146535.13 GNA12 7 Thrombin signalling through proteinase activated receptors (PARs); G alpha (12/13) signalling events Vascular smooth muscle contraction; Phospholipase D signaling pathway; cGMP-PKG signaling pathway; MAPK signaling pathway; Pathways in cancer; Long-term depression; Regulation of actin cytoskeleton; Sphingolipid signaling pathway 0 High Q96DV4 "39S ribosomal protein L38, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" 0 17.89 16 4 4 4 380 44.6 7.53 4 4 10664546 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome Pf01161 64978 ENSG00000204316.12 MRPL38 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High O00422 Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1 0 11.424 18 3 4 3 153 17.6 9.35 2 2 2 2 5270210.75 2455439.625 614023 3 2 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding Pf06487 10284 ENSG00000150459.12 SAP18 13 HDACs deacetylate histones; NoRC negatively regulates rRNA expression mRNA surveillance pathway; RNA transport 0 High Q96T88 E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1 0 11.589 5 3 4 3 793 89.8 7.56 3 4 3871549.25 3 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00097, Pf00240, Pf00628, Pf02182, Pf11976, Pf12148, Pf13639, Pf13923, Pf14634" 29128 ENSG00000276043.4 UHRF1 19 DNA methylation 0 High Q9NPC7 Myoneurin OS=Homo sapiens OX=9606 GN=MYNN PE=1 SV=1 0 8.394 6 3 4 2 610 68.6 8.25 3 4 1210369.125 253535.2031 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465" 55892 ENSG00000085274.15 MYNN 3 0 High Q8WVD3 E3 ubiquitin-protein ligase RNF138 OS=Homo sapiens OX=9606 GN=RNF138 PE=1 SV=1 0 13.854 18 3 4 3 245 28.2 6.93 3 1 3 1 4178051.094 976728.0625 43198.875 2 1 1 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00097, Pf02891, Pf05605, Pf13445, Pf13639, Pf13923, Pf14634, Pf14835" 51444 ENSG00000134758.13 RNF138 18 Antigen processing: Ubiquitination & Proteasome degradation 0 High Q8N5N7 "39S ribosomal protein L50, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" 0 11.384 25 3 4 3 158 18.3 7.88 2 1 2 2 3723122.875 331540.125 211858.0313 2 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome Pf10501 54534 ENSG00000136897.7 MRPL50 9 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q8NDV7 Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2 0 15.265 4 4 4 3 1962 210.2 7.01 1 1 2 1 1 2 462862.6875 1674390.125 615283 1298530 1 1 1 2 regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi protein binding;RNA binding "Pf10427, Pf13893, Pf14259" 27327 ENSG00000090905.18 TNRC6A 16 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 1 High Q8IUD2 ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1 0 6.167 2 2 4 2 1116 128 5.97 1 2 2 2 350486.6875 381534.0938 441174.375 196831.6406 1 1 1 1 development;metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;Golgi;membrane protein binding;transporter activity "Pf01496, Pf04156, Pf05529, Pf05557, Pf05622, Pf07888, Pf09457, Pf09726, Pf10174, Pf10186, Pf12128, Pf13166" 23085 ENSG00000283017.1; ENSG00000082805.19 ERC1 12; CHR_HSCHR12_2_CTG1 NF-kappa B signaling pathway 0 High Q99496 E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1 0 17.319 18 4 4 4 336 37.6 6.84 4 4 8365128.125 194273.3594 3 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;endosome;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00097, Pf11789, Pf13639, Pf13920, Pf13923, Pf14570, Pf14634, Pf14835, Pf15227" 6045 ENSG00000121481.10 RNF2 1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins 0 High P07477 Trypsin-1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1 0 5.117 12 2 4 2 247 26.5 6.51 2 4 1325368.5 1127067.875 3018937 1 1 1 cell organization and biogenesis;metabolic process extracellular catalytic activity;metal ion binding Pf00089 5644 ENSG00000274247.4; ENSG00000204983.13 PRSS1 7; CHR_HSCHR7_2_CTG6 "Activation of Matrix Metalloproteinases; Cobalamin (Cbl, vitamin B12) transport and metabolism" Neuroactive ligand-receptor interaction; Protein digestion and absorption; Pancreatic secretion; Influenza A 0 High P41743 Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2 0 21.546 13 4 4 4 596 68.2 5.85 4 4 5838834.5 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf00130, Pf00433, Pf00564, Pf07714, Pf14531" 5584 ENSG00000163558.12 PRKCI 3 Tight junction interactions; Signalling by NGF; p75NTR recruits signalling complexes Endocytosis; Tight junction; Insulin signaling pathway; Hippo signaling pathway; Rap1 signaling pathway; Platelet activation 0 High Q5VTE6 Protein angel homolog 2 OS=Homo sapiens OX=9606 GN=ANGEL2 PE=2 SV=1 0 20.433 12 3 4 3 544 62.3 7.81 3 4 3686674.5 1 regulation of biological process cytoplasm RNA binding Pf03372 90806 ENSG00000174606.13 ANGEL2 1 0 High Q16670 Zinc finger and SCAN domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZSCAN26 PE=1 SV=2 0 6.987 6 3 4 2 478 55.2 8.06 3 4 1111096.094 2 metabolic process;regulation of biological process cytosol;nucleus metal ion binding;protein binding "Pf00096, Pf02023, Pf13465" 7741 ENSG00000197062.11 ZNF187; ZSCAN26 6 0 High Q12834 Cell division cycle protein 20 homolog OS=Homo sapiens OX=9606 GN=CDC20 PE=1 SV=2 0 11.786 12 4 4 4 499 54.7 9.23 4 4 578690.8125 3760432 311762.6563 1 2 1 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol enzyme regulator activity;protein binding Pf00400 991 ENSG00000117399.13 CDC20 1 Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Ub-specific processing proteases; Phosphorylation of Emi1; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; SCF-beta-TrCP mediated degradation of Emi1; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A Viral carcinogenesis; Ubiquitin mediated proteolysis; HTLV-I infection; Oocyte meiosis; Cell cycle 0 High Q149N8 E3 ubiquitin-protein ligase SHPRH OS=Homo sapiens OX=9606 GN=SHPRH PE=1 SV=2 0 15.711 4 4 4 4 1683 193 7.47 4 4 9543619.5 6819689.125 2 3 cell organization and biogenesis;metabolic process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00176, Pf00271, Pf00538, Pf00628, Pf13639, Pf13920, Pf13923, Pf14634" 257218 ENSG00000146414.15 SHPRH 6 E3 ubiquitin ligases ubiquitinate target proteins 0 High P29122 Proprotein convertase subtilisin/kexin type 6 OS=Homo sapiens OX=9606 GN=PCSK6 PE=1 SV=1 0 11.359 4 4 4 4 969 106.4 7.68 1 3 1 3 245219.875 10123607.38 819024.625 3606028.875 1 3 2 4 cell death;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;extracellular;membrane;organelle lumen catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00082, Pf00757, Pf01483, Pf03302, Pf08686, Pf14843" 5046 ENSG00000140479.16 PCSK6 15 Signaling by NODAL; Assembly of active LPL and LIPC lipase complexes; Formation of the cornified envelope; Signalling by NGF; NGF processing 0 High Q96EF6 F-box only protein 17 OS=Homo sapiens OX=9606 GN=FBXO17 PE=1 SV=1 0 6.324 12 3 4 3 278 31.5 8.1 1 2 1 1 2 1 3114816.953 1540276.906 849023.9727 2 2 2 metabolic process cytosol catalytic activity;protein binding "Pf00646, Pf04300, Pf12937" 115290 ENSG00000282954.1; ENSG00000269190.5 FBXO17 19; CHR_HG26_PATCH Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q93009 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2 0 13.876 4 4 4 4 1102 128.2 5.55 3 1 3 1 422130.0625 3621041.313 499078.0938 1 2 1 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00443, Pf00917, Pf12436, Pf13423, Pf14533" 7874 ENSG00000187555.14 USP7 16 Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization Viral carcinogenesis; FoxO signaling pathway; Epstein-Barr virus infection; Herpes simplex infection 0 High Q8NE01 Metal transporter CNNM3 OS=Homo sapiens OX=9606 GN=CNNM3 PE=1 SV=1 0 10.003 6 4 4 4 707 76.1 6.09 4 4 6185931.25 2526285.875 2 2 transport membrane protein binding Pf00571 26505 ENSG00000168763.15 CNNM3 2 0 High Q5QJE6 Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Homo sapiens OX=9606 GN=DNTTIP2 PE=1 SV=2 0 14.8 6 4 4 4 756 84.4 6.16 4 4 8441607.125 9544.361328 4 1 metabolic process;regulation of biological process nucleus RNA binding Pf08698 30836 ENSG00000067334.13 DNTTIP2 1 0 High Q9HCJ0 Trinucleotide repeat-containing gene 6C protein OS=Homo sapiens OX=9606 GN=TNRC6C PE=1 SV=3 0 7.276 4 4 4 3 1690 175.9 6.96 1 1 2 1 1 2 349141.875 467811.4375 1 2 regulation of biological process;response to stimulus cytosol protein binding;RNA binding "Pf00076, Pf00627, Pf10427, Pf12938, Pf13893, Pf14259" 57690 ENSG00000078687.17 TNRC6C 17 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High Q9Y605 MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1 0 24.678 25 2 4 2 127 14.6 4.7 2 4 16533529.75 402278.4688 2 1 cytoplasm;cytosol;nucleus protein binding Pf15155 93621 ENSG00000179010.14 MRFAP1 4 0 High O75820 Zinc finger protein 189 OS=Homo sapiens OX=9606 GN=ZNF189 PE=1 SV=2 0 15.06 10 4 4 3 626 72.9 8.5 4 4 5932459.25 508123.2188 639336.6719 3 1 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf09723, Pf13465" 7743 ENSG00000136870.10 ZNF189 9 Generic Transcription Pathway 1 High P57071 PR domain zinc finger protein 15 OS=Homo sapiens OX=9606 GN=PRDM15 PE=1 SV=4 0 12.248 3 4 4 4 1507 169.2 8.24 4 4 2622961.375 512237.5156 2 2 metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00096, Pf13465" 63977 ENSG00000141956.13 PRDM15 21 0 High Q8NEP9 Zinc finger protein 555 OS=Homo sapiens OX=9606 GN=ZNF555 PE=1 SV=4 0 16.11 5 3 4 1 628 73 9.04 3 4 6702565.5 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf01352, Pf13465" 148254 ENSG00000186300.11 ZNF555 19 Generic Transcription Pathway 0 High P57740 Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1 0 5.205 4 3 4 3 925 106.3 5.43 1 3 1 3 1589347.906 1077163.813 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytosol;membrane;nucleus protein binding;structural molecule activity;transporter activity Pf04121 57122 ENSG00000111581.9 NUP107 12 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P79522 Proline-rich protein 3 OS=Homo sapiens OX=9606 GN=PRR3 PE=1 SV=2 0 26.094 28 3 4 3 188 20.6 9.83 3 4 587508.375 14046730 1 3 metal ion binding;protein binding;RNA binding Pf00642 80742 ENSG00000228186.10; ENSG00000206491.12; ENSG00000233564.10; ENSG00000223887.10; ENSG00000204576.11; ENSG00000223766.10; ENSG00000229202.10 PRR3 6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1 0 High Q8N5A5 Zinc finger CCCH-type with G patch domain-containing protein OS=Homo sapiens OX=9606 GN=ZGPAT PE=1 SV=3 0 7.405 5 2 4 2 531 57.3 5.43 2 4 45733.39063 4014573.75 1 2 metabolic process;regulation of biological process membrane;nucleus DNA binding;metal ion binding;protein binding "Pf00642, Pf01585" 84619 ENSG00000197114.11 ZGPAT 20 0 High Q5T280 Putative methyltransferase C9orf114 OS=Homo sapiens OX=9606 GN=SPOUT1 PE=1 SV=3 0 17.899 10 3 4 3 376 42 7.43 3 4 13779950.38 1126265.813 3 2 cell division;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton catalytic activity;RNA binding Pf02598 51490 ENSG00000198917.12 C9orf114; SPOUT1 9 0 High P21912 "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" 0 8.056 15 4 4 4 280 31.6 8.76 1 3 1 3 2384159.125 3630040.688 2 3 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf13085, Pf13183, Pf13534" 6390 ENSG00000117118.9 SDHB 1 Respiratory electron transport; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q8N9N2 Activating signal cointegrator 1 complex subunit 1 OS=Homo sapiens OX=9606 GN=ASCC1 PE=1 SV=1 0 19.057 12 3 4 3 400 45.5 5.54 3 4 15821418 2 metabolic process;regulation of biological process nucleus protein binding;RNA binding "Pf00013, Pf10469, Pf13014" 51008 ENSG00000138303.17 ASCC1 10 ALKBH3 mediated reversal of alkylation damage 0 High Q6P3S6 F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1 0 8.424 6 4 4 4 717 77.8 7.43 1 3 1 3 1956909.625 5144131.938 2177084.625 1711729.438 1 2 2 3 protein binding "Pf00646, Pf01344, Pf07646, Pf12937, Pf13415, Pf13418, Pf13854, Pf13964" 54455 ENSG00000037637.10 FBXO42 1 0 High Q13472 DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1 0 10.507 3 3 4 2 1001 112.3 8.34 1 1 1 2 1 1 4582989 1041353.844 583745.25 1 2 2 metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf01131, Pf01396, Pf01751, Pf06839" 7156 ENSG00000177302.14; ENSG00000284238.1 TOP3A 17; CHR_HSCHR17_3_CTG1 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Fanconi anemia pathway 0 High Q9P0T7 Transmembrane protein 9 OS=Homo sapiens OX=9606 GN=TMEM9 PE=1 SV=1 0 5.991 11 2 4 2 183 20.6 6.65 2 4 10657544 2122635.938 2 2 transport endosome;membrane;vacuole Pf05434 252839 ENSG00000116857.16 TMEM9 1 0 High O43824 Putative GTP-binding protein 6 OS=Homo sapiens OX=9606 GN=GTPBP6 PE=2 SV=4 0 21.98 11 4 4 4 516 56.9 9.42 4 4 492568.9063 12434836.63 1 4 0 High P04075 Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2 0 7.509 9 3 4 3 364 39.4 8.09 2 2 2 2 4953261.5 1180261.781 2 3 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00274 226 ENSG00000149925.17 ALDOA 16 Platelet degranulation ; Gluconeogenesis; Glycolysis; Neutrophil degranulation HIF-1 signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Pentose phosphate pathway; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 High P18583 Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4 0 12.175 2 4 4 4 2426 263.7 5.64 4 4 957720.875 13388537.25 1 4 cell organization and biogenesis;metabolic process;regulation of biological process extracellular;nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf01585, Pf03154, Pf05109, Pf07174, Pf12526, Pf14709" 6651 ENSG00000159140.19 SON 21 0 High Q12769 Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3 0 4.583 2 3 4 3 1436 162 5.5 3 4 597631.375 2336092.125 1103057.781 1 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytosol;nucleus protein binding;transporter activity Pf11715 23279 ENSG00000030066.13 NUP160 11 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q15436 Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2 0 6.205 6 3 4 3 765 86.1 7.08 2 2 2 2 923240.3281 966218.7188 2 2 cell organization and biogenesis;transport cytoplasm;cytosol;endoplasmic reticulum;membrane metal ion binding;protein binding "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" 10484 ENSG00000100934.14 SEC23A 14 "Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" Protein processing in endoplasmic reticulum 0 High Q53F19 Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2 0 14.902 7 4 4 4 620 70.5 5.73 4 4 35901111.63 4 defense response;metabolic process;response to stimulus;transport cytoplasm;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf08675, Pf10309" 55421 ENSG00000074356.16 C17orf85; NCBP3 17 0 High Q9Y4G6 Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4 0.001 3.202 1 2 4 1 2542 271.4 5.57 1 2 1 3 12586992 1 cell organization and biogenesis cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379" 83660 ENSG00000171914.16 TLN2 15 Rap1 signaling pathway; HTLV-I infection; Focal adhesion; Platelet activation 0 High Q8WW12 PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2 0 9.669 25 3 4 3 178 18.9 7.49 3 4 1611460.5 1 metabolic process nucleus protein binding Pf15473 57092 ENSG00000081154.11 PCNP 3 0 High Q9BWS9 Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1 0 4.554 4 2 3 2 393 44.9 8.63 2 3 8777928.125 1280313.703 4803919.75 2 2 2 defense response;metabolic process;regulation of biological process;response to stimulus;transport endosome;extracellular;membrane;nucleus;organelle lumen;vacuole catalytic activity;protein binding Pf00704 66005 ENSG00000177830.17 CHID1 11 Platelet degranulation 0 High Q9UI30 Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1 0 11.274 21 2 3 2 125 14.2 5.26 2 3 11265606 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding Pf03966 51504 ENSG00000173113.6 TRMT112 11 tRNA modification in the nucleus and cytosol; Eukaryotic Translation Termination; rRNA modification in the nucleus and cytosol; Methylation 0 High P18075 Bone morphogenetic protein 7 OS=Homo sapiens OX=9606 GN=BMP7 PE=1 SV=1 0 6.604 5 2 3 2 431 49.3 7.85 2 3 715589.5625 1637500.906 1 2 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;development;regulation of biological process;response to stimulus extracellular protein binding "Pf00019, Pf00688" 655 ENSG00000101144.12 BMP7 20 Molecules associated with elastic fibres TGF-beta signaling pathway; Cytokine-cytokine receptor interaction; Hippo signaling pathway; Axon guidance 0 High P30876 DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1 0 7.377 2 3 3 2 1174 133.8 6.87 1 2 1 2 1181635.125 954750.625 287818.875 1 2 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" 5431 ENSG00000047315.15 POLR2B 4 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex Epstein-Barr virus infection; Huntington's disease; Purine metabolism; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High P40222 Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3 0 9.923 10 3 3 3 546 61.9 6.52 3 3 2050823.25 1 cell proliferation;regulation of biological process;transport cytoplasm;cytosol;extracellular;membrane protein binding Pf09728 200081 ENSG00000084652.15 TXLNA 1 Other interleukin signaling 0 High P49006 MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2 0 5.902 31 3 3 3 195 19.5 4.67 1 1 1 1 1 1 144747.7344 410228.2188 1 1 regulation of biological process cytoplasm;membrane protein binding 65108 ENSG00000175130.6 MARCKSL1 1 Leishmaniasis; Fc gamma R-mediated phagocytosis 0 High Q9NR56 Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2 0 9.82 11 3 3 3 388 41.8 8.9 3 3 3194521.375 2 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus metal ion binding;protein binding;RNA binding 4154 ENSG00000152601.17 MBNL1 3 0 High Q9Y251 Heparanase OS=Homo sapiens OX=9606 GN=HPSE PE=1 SV=2 0 7.363 5 3 3 3 543 61.1 9.28 3 3 7285029.563 4374897.875 157578.8281 2 2 1 metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;nucleus;organelle lumen;vacuole catalytic activity;protein binding Pf03662 10855 ENSG00000173083.14 HPSE 4 HS-GAG degradation; Neutrophil degranulation Glycosaminoglycan degradation; Proteoglycans in cancer; Metabolic pathways 0 High Q5T200 Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1 0 14.877 2 3 3 3 1668 196.5 9.42 3 3 7745732.25 2 nucleus metal ion binding;protein binding;RNA binding Pf00642 23091 ENSG00000123200.16 ZC3H13 13 0 High O75717 WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1 0 7.276 3 3 3 3 1129 125.9 5.62 3 3 1307000.688 2050549.875 838658.9375 2210649.25 3 1 1 1 cytoplasm;nucleus DNA binding;protein binding "Pf00400, Pf00505, Pf08662" 11169 ENSG00000198554.11 WDHD1 14 0 High Q99805 Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1 0 8.955 6 3 3 3 663 75.7 7.44 3 3 2435889 983975.6563 1 2 transport endosome;membrane "Pf02990, Pf07690" 9375 ENSG00000125304.8 TM9SF2 13 0 High O75891 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH1L1 PE=1 SV=2 0 8.979 4 3 3 3 902 98.8 5.94 3 3 2673789.844 909973.25 1024454.953 2 2 3 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity "Pf00171, Pf00550, Pf00551, Pf02911" 10840 ENSG00000144908.13 ALDH1L1 3 Metabolism of folate and pterines One carbon pool by folate 0 High Q9BUL9 Ribonuclease P protein subunit p25 OS=Homo sapiens OX=9606 GN=RPP25 PE=1 SV=1 0 11.231 20 3 3 3 199 20.6 9.61 3 3 263724.0938 11103843.75 1693903.617 1445698.928 1 3 2 2 metabolic process nucleus catalytic activity;protein binding;RNA binding Pf01918 54913 ENSG00000178718.6 RPP25 15 Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High Q9NS86 LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1 0 11.852 10 3 3 3 450 50.8 7.43 3 3 1170406.75 1 regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus nucleotide binding;protein binding Pf05147 55915 ENSG00000132434.9 LANCL2 7 0 High Q96GD4 Aurora kinase B OS=Homo sapiens OX=9606 GN=AURKB PE=1 SV=3 0 13.793 12 3 3 3 344 39.3 9.29 3 3 254136.4531 8827087.5 592304.875 976789 1 3 1 1 cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714" 9212 ENSG00000178999.12 AURKB 17 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Regulation of TP53 Activity through Phosphorylation 0 High Q6PK18 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=OGFOD3 PE=1 SV=2 0 7.503 15 3 3 3 319 35.6 8.18 3 3 131744.6094 2167700.906 1 3 metabolic process membrane catalytic activity;metal ion binding Pf13640 79701 ENSG00000181396.12 OGFOD3 17 0 High P60228 Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1 0 14.919 6 2 3 2 445 52.2 6.04 2 3 583675.25 4333828.125 8175.498535 1 2 1 metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf01399, Pf09440" 3646 ENSG00000104408.9 EIF3E 8 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport; Hepatitis C 0 High Q7Z2W9 "39S ribosomal protein L21, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" 0 12.956 11 2 3 2 205 22.8 9.89 2 3 3630201 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00829 219927 ENSG00000197345.12 MRPL21 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9HDC5 Junctophilin-1 OS=Homo sapiens OX=9606 GN=JPH1 PE=1 SV=2 0 10.038 7 3 3 3 661 71.6 9.32 3 3 349377.5 2478723.125 2434741.25 2247257.75 1 2 1 1 cellular homeostasis;regulation of biological process;transport endoplasmic reticulum;membrane structural molecule activity Pf02493 56704 ENSG00000104369.4 JPH1 8 0 High Q12996 Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1 0.001 4.291 3 2 3 2 717 82.9 8.12 2 3 1371105.625 2 metabolic process nucleus protein binding;RNA binding Pf05843 1479 ENSG00000176102.11 CSTF3 11 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High Q6P161 "39S ribosomal protein L54, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" 0.001 3.846 7 1 3 1 138 15.8 9.6 1 1 2 1 3771779.5 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding Pf08561 116541 ENSG00000183617.4 MRPL54 19 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q8N567 Zinc finger CCHC domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ZCCHC9 PE=1 SV=2 0 9.728 9 3 3 3 271 30.5 9.17 3 3 1463356.875 1 metabolic process;regulation of biological process nucleus metal ion binding;RNA binding 84240 ENSG00000131732.11 ZCCHC9 5 0 High Q8WWY3 U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2 0 11.556 7 3 3 3 499 55.4 5.78 3 3 45925.76172 5544629.125 8055.973145 1 3 1 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf01798, Pf08060, Pf09785" 26121 ENSG00000275117.4; ENSG00000277953.4; ENSG00000105618.13; ENSG00000277154.4; ENSG00000274894.4; ENSG00000274651.4; ENSG00000277707.4; ENSG00000276421.4; ENSG00000274144.4; ENSG00000275885.4 PRPF31 19; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19_4_CTG3_1 mRNA Splicing - Major Pathway Spliceosome 0 High O43837 "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" 0 8.011 8 3 3 3 385 42.2 8.46 1 2 1 2 884413.1875 797198.5625 2 2 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding Pf00180 3420 ENSG00000101365.20 IDH3B 20 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Metabolic pathways 0 High Q9BQB6 Vitamin K epoxide reductase complex subunit 1 OS=Homo sapiens OX=9606 GN=VKORC1 PE=1 SV=1 0 4.631 8 1 3 1 163 18.2 9.36 1 1 2 1 1295969.875 2385872.25 4115765.75 1 1 1 coagulation;metabolic process endoplasmic reticulum;membrane catalytic activity Pf07884 79001 ENSG00000167397.14 VKORC1 16 Metabolism of vitamin K Ubiquinone and other terpenoid-quinone biosynthesis 0 High O75394 "39S ribosomal protein L33, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL33 PE=1 SV=1" 0 9.911 38 2 3 2 65 7.6 10.8 2 3 146069.0781 6242842.5 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity "Pf00471, Pf06204" 9553 ENSG00000243147.7 MRPL33 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9UQB8 Brain-specific angiogenesis inhibitor 1-associated protein 2 OS=Homo sapiens OX=9606 GN=BAIAP2 PE=1 SV=1 0 7.445 5 3 3 3 552 60.8 8.9 3 3 5310029 3 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane protein binding "Pf00018, Pf07653, Pf08397, Pf14604" 10458 ENSG00000175866.15 BAIAP2 17 Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs Adherens junction; Regulation of actin cytoskeleton 0 High Q8IZ52 Chondroitin sulfate synthase 2 OS=Homo sapiens OX=9606 GN=CHPF PE=1 SV=2 0 6.311 5 3 3 3 775 85.4 6.93 3 3 690444.875 6853152.5 1411389.313 1 1 2 metabolic process cytoplasm;cytosol;Golgi;membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf02434, Pf05679" 79586 ENSG00000123989.13 CHPF 2 Chondroitin sulfate biosynthesis Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High Q9BXK1 Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1 0 16.263 19 3 3 3 252 25.4 9.88 3 3 6262824.5 2 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding Pf13465 83855 ENSG00000129911.8 KLF16 19 0 High Q8NC56 LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LEMD2 PE=1 SV=1 0 8.002 5 2 3 2 503 56.9 9 2 1 2 1 3093603.063 735226.5625 1128232 923119.625 2 1 1 2 cell differentiation;cell organization and biogenesis;regulation of biological process chromosome;endoplasmic reticulum;membrane;nucleus DNA binding;protein binding "Pf03020, Pf09402" 221496 ENSG00000161904.11 LEMD2 6 Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2 0.001 3.787 5 2 3 2 385 44.1 6.23 1 1 2 1 2141187 1867274.75 1 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf04855 6598 ENSG00000099956.18; ENSG00000275837.3 SMARCB1 22; CHR_HSCHR22_1_CTG7 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q13136 Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1 0 13.054 4 3 3 3 1202 135.7 6.29 1 2 1 2 2386197.5 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi;nucleus catalytic activity;motor activity;protein binding;signal transducer activity "Pf00536, Pf01576, Pf02463, Pf04012, Pf04111, Pf04156, Pf05557, Pf05622, Pf06008, Pf06160, Pf06391, Pf07647, Pf09726, Pf09728, Pf09731, Pf10174, Pf12072, Pf12128, Pf12718, Pf12795, Pf13166, Pf13851, Pf14915, Pf15066, Pf15070, Pf15619" 8500 ENSG00000131626.16 PPFIA1 11 Norepinephrine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases; Glutamate Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle 0 High P20073 Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3 0 7.385 6 3 3 3 488 52.7 5.68 3 3 11290212.5 237772.0781 68604.32031 3 1 1 cell differentiation;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus metal ion binding;protein binding;RNA binding Pf00191 310 ENSG00000138279.15 ANXA7 10 0 High Q9Y2X0 Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2 0 5.667 3 3 3 3 877 96.7 7.37 3 3 157203.1875 1127761.375 1984450.656 1 1 3 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;protein binding;receptor activity "Pf00400, Pf11635" 10025 ENSG00000175221.14 MED16 19 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High Q9NZV5 Selenoprotein N OS=Homo sapiens OX=9606 GN=SELENON PE=1 SV=5 0.001 3.839 5 2 3 2 590 65.8 5.48 2 3 26984658 592995.8379 2768472.879 1 2 2 metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding 57190 ENSG00000162430.16 SEPN1; SELENON 1 0 High Q6WCQ1 Myosin phosphatase Rho-interacting protein OS=Homo sapiens OX=9606 GN=MPRIP PE=1 SV=3 0 6.765 5 3 3 3 1025 116.5 6.21 1 1 1 1 1 1 30102978 334258.8125 1 1 cytoplasm;cytoskeleton;cytosol protein binding Pf00169 23164 ENSG00000133030.20 MPRIP 17 Signaling by BRAF and RAF fusions 0 High Q9UJZ1 "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" 0 5.499 13 2 3 2 356 38.5 7.39 1 1 1 1 1 1 676883.6875 317590.7813 1030941.625 775153.9375 1 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;mitochondrion protein binding Pf01145 30968 ENSG00000165283.15 STOML2 9 Processing of SMDT1 0 High Q7Z6M4 "Transcription termination factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF4 PE=1 SV=3" 0 9.449 8 3 3 3 381 43.9 4.82 3 3 5008276.625 45868.80859 3 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;mitochondrion;organelle lumen DNA binding;protein binding;RNA binding 130916 ENSG00000122085.16 MTERFD2; MTERF4 2 rRNA modification in the mitochondrion 0 High Q8NFQ8 Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1 0 8.123 7 3 3 3 470 51.2 4.96 3 3 1075852.438 2 cell organization and biogenesis;regulation of biological process endoplasmic reticulum;membrane;nucleus enzyme regulator activity;protein binding Pf05609 163590 ENSG00000169905.12 TOR1AIP2 1 0 High Q9ULD5 Zinc finger protein 777 OS=Homo sapiens OX=9606 GN=ZNF777 PE=1 SV=3 0 4.845 4 3 3 2 831 93.7 6.61 3 3 3963406.125 2 1 High Q9BZM1 Group XIIA secretory phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G12A PE=1 SV=1 0 10.316 8 1 3 1 189 21.1 7.24 1 3 4285203 1 metabolic process;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi catalytic activity;metal ion binding Pf06951 81579 ENSG00000123739.10 PLA2G12A 4 Acyl chain remodelling of PI; Synthesis of PA; Acyl chain remodelling of PG; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PC Fat digestion and absorption; Ether lipid metabolism; Vascular smooth muscle contraction; Arachidonic acid metabolism; Linoleic acid metabolism; Pancreatic secretion; Glycerophospholipid metabolism; Ras signaling pathway; alpha-Linolenic acid metabolism; Metabolic pathways 0 High A8MXZ3 Keratin-associated protein 9-1 OS=Homo sapiens OX=9606 GN=KRTAP9-1 PE=3 SV=1 0 11.575 6 1 3 1 250 26.3 7.61 1 3 6338856.5 2 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 728318 ENSG00000240542.4 KRTAP9-1 17 Keratinization 0 High Q9Y6G3 "39S ribosomal protein L42, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL42 PE=1 SV=1" 0 11.626 30 2 3 2 142 16.7 8.35 2 3 179911.5156 5674880 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf10210 28977 ENSG00000198015.12 MRPL42 12 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q9H967 WD repeat-containing protein 76 OS=Homo sapiens OX=9606 GN=WDR76 PE=1 SV=2 0 8.881 5 3 3 3 626 69.7 9.25 3 3 1735145.625 1 regulation of biological process;response to stimulus nucleus DNA binding;protein binding Pf00400 79968 ENSG00000092470.11 WDR76 15 0 High Q7Z7K6 Centromere protein V OS=Homo sapiens OX=9606 GN=CENPV PE=1 SV=1 0 17.227 16 3 3 3 275 29.9 9.73 3 3 119247.0703 4237820 107262.7813 826087.3545 1 3 1 2 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process chromosome;cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity Pf04828 201161 CENPV 17 0 Medium Q9UKN7 Unconventional myosin-XV OS=Homo sapiens OX=9606 GN=MYO15A PE=1 SV=2 0.035 1.338 0 1 3 1 3530 395 9.17 1 1 1 1 1 1 900032192 48905092 15039245 1 1 1 response to stimulus cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00373, Pf00784, Pf07653, Pf15279" 51168 ENSG00000091536.16 MYO15A 17 0 Medium Q8WXE9 Stonin-2 OS=Homo sapiens OX=9606 GN=STON2 PE=1 SV=1 0.011 1.859 1 1 3 1 905 101.1 5.39 1 1 1 1 1 1 1274866.125 893991.25 5213042.676 3820325.5 1 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;membrane protein binding "Pf00928, Pf12016" 85439 ENSG00000140022.9 STON2 14 Cargo recognition for clathrin-mediated endocytosis 0 High Q96D09 G-protein coupled receptor-associated sorting protein 2 OS=Homo sapiens OX=9606 GN=GPRASP2 PE=1 SV=1 0 11.291 4 3 3 3 838 93.7 5.01 3 3 1945070.938 2 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding "Pf04826, Pf10508" 114928; 100528062 ENSG00000158301.18 GPRASP2; ARMCX5-GPRASP2 X 0 High Q9UER7 Death domain-associated protein 6 OS=Homo sapiens OX=9606 GN=DAXX PE=1 SV=2 0 16.432 7 2 3 2 740 81.3 4.87 2 3 7022760.25 2 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus enzyme regulator activity;protein binding;signal transducer activity Pf03344 1616 ENSG00000231617.8; ENSG00000204209.11; ENSG00000206279.10; ENSG00000206206.11; ENSG00000227046.8 DAXX 6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1 Regulation of TP53 Degradation MAPK signaling pathway; Apoptosis; Herpes simplex infection; Amyotrophic lateral sclerosis (ALS) 0 High Q13107 Ubiquitin carboxyl-terminal hydrolase 4 OS=Homo sapiens OX=9606 GN=USP4 PE=1 SV=3 0.003 2.721 2 1 3 1 963 108.5 5.71 1 3 115603135 4997107 10162630.5 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;vacuole catalytic activity;metal ion binding;protein binding "Pf00443, Pf06337, Pf13423, Pf14836" 7375 ENSG00000114316.12 USP4 3 Regulation of TNFR1 signaling; Ub-specific processing proteases; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling 0 High O43159 Ribosomal RNA-processing protein 8 OS=Homo sapiens OX=9606 GN=RRP8 PE=1 SV=2 0 7.059 9 3 3 3 456 50.7 9.42 3 3 7860315.5 3 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf05148, Pf08241, Pf08242, Pf13489, Pf13847" 23378 ENSG00000132275.10 RRP8 11 SIRT1 negatively regulates rRNA expression 0 High Q9NV06 DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2 0 19.069 11 3 3 3 445 51.4 9.19 3 3 6590120 721517.4375 2 1 metabolic process cytosol;nucleus protein binding;RNA binding "Pf00400, Pf04158" 25879 ENSG00000164934.13 DCAF13 8 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Neddylation 0 High Q96QC0 Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1 0 11.029 6 3 3 3 940 99 9.17 3 3 3113953.5 105352.3242 2 2 metabolic process;regulation of biological process;transport chromosome;nucleus DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding "Pf00642, Pf08711" 5514 ENSG00000238104.7; ENSG00000231737.7; ENSG00000206489.9; ENSG00000230995.7; ENSG00000204569.9; ENSG00000227804.7; ENSG00000235291.7 PPP1R10 6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1 0 High Q7Z6M2 F-box only protein 33 OS=Homo sapiens OX=9606 GN=FBXO33 PE=1 SV=1 0.002 2.802 3 2 3 1 555 62.6 7.36 1 1 2 1 868034.8125 310319.8438 1 1 metabolic process protein binding "Pf00646, Pf12937" 254170 ENSG00000165355.7 FBXO33 14 0 High P22695 "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" 0 8.209 11 3 3 3 453 48.4 8.63 3 3 189620.6563 1318680 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00675, Pf05193" 7385 ENSG00000140740.10; ENSG00000284493.1 UQCRC2 16; CHR_HG926_PATCH Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 High P47813 "Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2" 0 4.734 35 3 3 3 144 16.5 5.24 3 3 3437497 92275.97656 2 1 metabolic process cytosol protein binding;RNA binding Pf01176 1964; 107984923 ENSG00000173674.10 EIF1AX; LOC101060318; LOC107984923 X; 1 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High O75503 Ceroid-lipofuscinosis neuronal protein 5 OS=Homo sapiens OX=9606 GN=CLN5 PE=1 SV=2 0 7.017 6 2 3 2 358 41.5 7.4 2 3 7085480.5 3077756.125 2 2 cell differentiation;cellular homeostasis;metabolic process;transport cytosol;endoplasmic reticulum;Golgi;membrane;vacuole protein binding Pf15014 1203 ENSG00000102805.14 CLN5 13 Lysosome 0 High O43818 U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1 0 12.794 7 3 3 3 475 51.8 7.85 3 3 3485240.25 2 metabolic process nucleus protein binding;RNA binding Pf00400 9136 ENSG00000114767.6 RRP9 3 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q92545 Transmembrane protein 131 OS=Homo sapiens OX=9606 GN=TMEM131 PE=1 SV=3 0 7.696 2 3 3 3 1883 205 8.59 1 1 1 1 1 1 2151616.75 2089056.313 2695175.75 1 3 2 membrane Pf12371 23505 ENSG00000075568.16 TMEM131 2 0 High P30260 Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2 0 4.839 2 2 3 2 824 91.8 7.02 1 2 1 2 1520927.813 921013.3438 2 2 cell proliferation;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus protein binding "Pf00515, Pf05109, Pf07719, Pf12895, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559" 996 ENSG00000004897.11 CDC27 17 APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP) Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 High Q99538 Legumain OS=Homo sapiens OX=9606 GN=LGMN PE=1 SV=1 0 15.328 9 3 3 3 433 49.4 6.55 3 3 2695171.5 2197283.063 1448803.313 2 2 3 metabolic process;regulation of biological process;response to stimulus endosome;organelle lumen;vacuole catalytic activity Pf01650 5641 ENSG00000100600.14 LGMN 14 Vitamin D (calciferol) metabolism; MHC class II antigen presentation; Trafficking and processing of endosomal TLR Lysosome; Antigen processing and presentation 0 High P81605 Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2 0 6.869 23 2 3 2 110 11.3 6.54 1 2 1 2 527484.3125 1861225.672 670871.875 1 2 1 defense response;metabolic process;response to stimulus extracellular catalytic activity;protein binding;RNA binding Pf15291 117159 ENSG00000161634.11 DCD 12 Antimicrobial peptides 0 High P54709 Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1 0.001 3.694 6 2 3 2 279 31.5 8.35 2 3 931226.9375 576377.5 1553561.156 1 1 2 cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;transport cytoplasm;membrane catalytic activity;enzyme regulator activity;protein binding;transporter activity Pf00287 483 ENSG00000069849.10 ATP1B3 3 Ion homeostasis; Basigin interactions; Ion transport by P-type ATPases Bile secretion; cGMP-PKG signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Protein digestion and absorption; Proximal tubule bicarbonate reclamation; Thyroid hormone signaling pathway; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Pancreatic secretion; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Gastric acid secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Mineral absorption 0 High Q2TBE0 CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4 0 6.917 3 2 3 2 894 103.7 8.65 2 3 2812802.625 2140315.75 2289833.5 2 1 1 catalytic activity;protein binding "Pf04676, Pf04677" 143884 ENSG00000152404.15 CWF19L2 11 0 High Q13309 S-phase kinase-associated protein 2 OS=Homo sapiens OX=9606 GN=SKP2 PE=1 SV=2 0 5.79 7 3 3 3 424 47.7 7.11 1 2 1 2 1623054.813 1362066.125 1062623.906 2 3 3 cell communication;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00646, Pf12937" 6502 ENSG00000145604.15 SKP2 5 Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Cyclin D associated events in G1; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; SCF(Skp2)-mediated degradation of p27/p21 Viral carcinogenesis; FoxO signaling pathway; Ubiquitin mediated proteolysis; Epstein-Barr virus infection; Pathways in cancer; mTOR signaling pathway; Small cell lung cancer; Herpes simplex infection; Cell cycle 0 High Q15427 Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1 0 14.15 9 2 3 2 424 44.4 8.56 1 2 1 2 561837.7188 16463642.5 1 2 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10262 ENSG00000143368.9 SF3B4 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High A0A0C4DH72 Immunoglobulin kappa variable 1-6 OS=Homo sapiens OX=9606 GN=IGKV1-6 PE=3 SV=1 0.003 2.513 14 1 3 1 117 12.7 8.29 1 1 2 1 1896541.125 2275633.5 1 1 response to stimulus extracellular;membrane "Pf00047, Pf07679, Pf07686, Pf13927" 28943 ENSG00000282163.1; ENSG00000239855.1 IGKV1-6 2; CHR_HG2290_PATCH 0 High Q6ZUT1 Uncharacterized protein NKAPD1 OS=Homo sapiens OX=9606 GN=NKAPD1 PE=1 SV=2 0 4.725 6 2 3 2 292 34.1 9.73 1 2 1 2 699031.75 137915.3906 1 1 protein binding 55216 ENSG00000150776.17 C11orf57; NKAPD1 11 0 High Q9Y3S1 Serine/threonine-protein kinase WNK2 OS=Homo sapiens OX=9606 GN=WNK2 PE=1 SV=4 0 5.828 1 3 3 1 2297 242.5 6.13 3 3 563410.3125 162396.1719 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding "Pf00069, Pf07714, Pf12202" 65268 ENSG00000165238.16 WNK2 9 Stimuli-sensing channels 0 High Q96D46 60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1 0 8.314 9 3 3 3 503 57.6 7.14 3 3 661495.25 3638567.875 1 2 regulation of biological process;transport cytoplasm;membrane;nucleus protein binding;RNA binding Pf04981 51068 ENSG00000169251.12 NMD3 3 Ribosome biogenesis in eukaryotes; RNA transport 0 High Q9Y2D8 Afadin- and alpha-actinin-binding protein OS=Homo sapiens OX=9606 GN=SSX2IP PE=1 SV=3 0 14.479 7 3 3 3 614 71.2 6.4 3 3 1324908.5 1 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;nucleus protein binding "Pf03961, Pf11559" 117178 ENSG00000117155.16 SSX2IP 1 Adherens junction 0 High Q53GQ0 Very-long-chain 3-oxoacyl-CoA reductase OS=Homo sapiens OX=9606 GN=HSD17B12 PE=1 SV=2 0 6.09 7 3 3 3 312 34.3 9.32 3 3 105725.1719 6724869.375 3974428.625 1 2 3 cell organization and biogenesis;metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00106, Pf03435, Pf08659, Pf13460, Pf13561" 51144 ENSG00000149084.12 HSD17B12 11 Androgen biosynthesis; Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; Steroid hormone biosynthesis 0 High Q8IX18 Probable ATP-dependent RNA helicase DHX40 OS=Homo sapiens OX=9606 GN=DHX40 PE=1 SV=2 0 9.168 4 3 3 3 779 88.5 8.65 3 3 4537055.875 649031.9375 3 1 metabolic process;transport cytoplasm;spliceosomal complex catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf00437, Pf04408, Pf07717" 79665 ENSG00000108406.9 DHX40 17 0 High P0DPB6 DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1 0 9.666 22 2 3 2 133 15.2 5.8 2 3 193855.5781 12120825.5 520926.375 1 2 1 0 High Q6P2E9 Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1 0 11.099 3 3 3 3 1401 151.6 5.86 1 2 1 2 362395.5313 1821530.5 531423.9375 1 1 1 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane;nucleus protein binding Pf00400 23644 ENSG00000038358.14 EDC4 16 mRNA decay by 5' to 3' exoribonuclease RNA degradation 0 High Q13144 Translation initiation factor eIF-2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3 0 15.195 4 2 3 2 721 80.3 5.08 2 3 461027.625 4038737.75 354744.2188 1 2 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00132, Pf02020" 8893 ENSG00000145191.12 EIF2B5 3 Recycling of eIF2:GDP RNA transport 0 High Q14679 Tubulin polyglutamylase TTLL4 OS=Homo sapiens OX=9606 GN=TTLL4 PE=1 SV=2 0 12.095 4 2 3 2 1199 133.3 8.85 2 3 2685072.188 27136.11328 2 1 metabolic process cytoplasm;cytoskeleton;cytosol catalytic activity;nucleotide binding;protein binding Pf03133 9654 ENSG00000135912.10 TTLL4 2 Carboxyterminal post-translational modifications of tubulin 0 High Q96HR8 H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2 0 15.043 9 2 3 2 494 53.7 4.87 2 3 3963655.75 2 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding;RNA binding Pf04410 92345 ENSG00000145414.8 NAF1 4 0 High P43250 G protein-coupled receptor kinase 6 OS=Homo sapiens OX=9606 GN=GRK6 PE=1 SV=2 0 16.352 8 3 3 3 576 65.9 8 3 3 4616765.563 3 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf00615, Pf07714" 2870 ENSG00000198055.10 GRK6 5 G alpha (s) signalling events Endocytosis; Morphine addiction; Chemokine signaling pathway 0 High Q8IW92 Beta-galactosidase-1-like protein 2 OS=Homo sapiens OX=9606 GN=GLB1L2 PE=2 SV=1 0 6.958 4 2 3 2 636 72 7.62 2 3 1496070.125 1020790.813 1 1 metabolic process extracellular;vacuole catalytic activity "Pf01301, Pf02449" 89944 ENSG00000149328.14 GLB1L2 11 0 High Q08379 Golgin subfamily A member 2 OS=Homo sapiens OX=9606 GN=GOLGA2 PE=1 SV=3 0 12.493 5 3 3 3 1002 113 5.02 3 3 5540186 280865.4688 2 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding "Pf01576, Pf15070" 2801 ENSG00000167110.17 GOLGA2 9 COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Golgi Cisternae Pericentriolar Stack Reorganization; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 0 High P19447 General transcription and DNA repair factor IIH helicase subunit XPB OS=Homo sapiens OX=9606 GN=ERCC3 PE=1 SV=1 0 9.16 4 3 3 3 782 89.2 7.23 3 3 7330173.75 785342 2 1 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00271, Pf04851, Pf13625" 2071 ENSG00000163161.12 ERCC3 2 Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; RNA Polymerase I Promoter Escape; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; Formation of Incision Complex in GG-NER; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Dual incision in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex Basal transcription factors; Nucleotide excision repair 0 High Q7L576 Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1 0 7.099 2 3 3 3 1253 145.1 6.9 3 3 3341688 2 cell differentiation;cell growth;cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;organelle lumen protein binding;RNA binding "Pf05994, Pf07159" 23191 ENSG00000273749.4 CYFIP1 15 Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; Neutrophil degranulation; RHO GTPases Activate WASPs and WAVEs Regulation of actin cytoskeleton; RNA transport 0 High P24863 Cyclin-C OS=Homo sapiens OX=9606 GN=CCNC PE=1 SV=2 0.003 2.744 4 1 3 1 283 33.2 7.33 1 1 2 1 898124.1875 787577.4375 1 1 metabolic process;regulation of biological process nucleus catalytic activity;enzyme regulator activity;protein binding Pf00134 892 ENSG00000112237.12 CCNC 6 NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression 0 High Q9Y3D5 "28S ribosomal protein S18c, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18C PE=1 SV=1" 0 9.453 19 2 3 2 142 15.8 9.55 2 3 819506.4375 8615511.625 32872.69531 147215.4766 1 2 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf01084 51023 ENSG00000163319.10 MRPS18C 4 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q53GS7 Nucleoporin GLE1 OS=Homo sapiens OX=9606 GN=GLE1 PE=1 SV=2 0 8.049 6 3 3 3 698 79.8 7.43 3 3 673321.25 4972840.5 1 2 regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding "Pf07817, Pf13654" 2733 ENSG00000119392.14 GLE1 9 Transport of Mature mRNA derived from an Intron-Containing Transcript 0 High Q9Y277 Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3 PE=1 SV=1 0 5.57 6 2 3 2 283 30.6 8.66 1 1 1 2 682955.9375 1088081.125 1456116.563 1 1 2 cell communication;defense response;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus nucleotide binding;transporter activity Pf01459 7419 ENSG00000078668.13 VDAC3 8 Mitochondrial calcium ion transport; Ub-specific processing proteases Viral carcinogenesis; NOD-like receptor signaling pathway; Hepatitis B; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High A5YKK6 CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2 0.001 3.78 1 2 3 2 2376 266.8 7.11 2 1 2 1 868413.2813 1438186.5 334723.6875 57932.95313 2 1 1 1 development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding;RNA binding;structural molecule activity "Pf04054, Pf12842" 23019 ENSG00000125107.17 CNOT1 16 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA RNA degradation 0 High Q7L2Z9 Centromere protein Q OS=Homo sapiens OX=9606 GN=CENPQ PE=1 SV=1 0 12.373 18 3 3 3 268 30.6 9.42 3 3 346523.4375 10135185.59 38053.125 1 2 1 cell organization and biogenesis chromosome;cytoskeleton;cytosol;nucleus Pf13094 55166 ENSG00000031691.6 CENPQ 6 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Deposition of new CENPA-containing nucleosomes at the centromere 0 High P60059 Protein transport protein Sec61 subunit gamma OS=Homo sapiens OX=9606 GN=SEC61G PE=1 SV=1 0.001 4.289 18 1 3 1 68 7.7 9.99 1 1 1 1 1 1 135698.7969 784445.875 247531.8594 1 1 1 Acetyl [N-Term] transport cytosol;endoplasmic reticulum;membrane protein binding;transporter activity Pf00584 23480 ENSG00000132432.13 SEC61G 7 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 High Q96AE7 Tetratricopeptide repeat protein 17 OS=Homo sapiens OX=9606 GN=TTC17 PE=1 SV=1 0 4.889 2 2 3 2 1141 129.5 6.58 1 2 1 2 460136.25 692406 1 1 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00515, Pf02841, Pf13414, Pf13424, Pf13432" 55761 ENSG00000052841.14 TTC17 11 0 High Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens OX=9606 GN=CAMK2A PE=1 SV=2 0 6.786 3 1 3 1 478 54.1 7.08 1 1 2 1 4353924.5 603393.5625 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf08332, Pf13474, Pf14534" 815 ENSG00000070808.15 CAMK2A 5 "Ion homeostasis; HSF1-dependent transactivation; Interferon gamma signaling; Ca2+ pathway; Phase 0 - rapid depolarisation; Ras activation uopn Ca2+ infux through NMDA receptor; Ion transport by P-type ATPases; Unblocking of NMDA receptor, glutamate binding and activation; Trafficking of AMPA receptors; CREB phosphorylation through the activation of CaMKII; RAF/MAP kinase cascade; Interleukin-20 family signaling" Dopaminergic synapse; HIF-1 signaling pathway; Amphetamine addiction; Neurotrophin signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; ErbB signaling pathway; Long-term potentiation; Insulin secretion; Glioma; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Melanogenesis; Wnt signaling pathway; Proteoglycans in cancer; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Axon guidance; cAMP signaling pathway; Cholinergic synapse; Calcium signaling pathway 0 High Q8IYA6 Cytoskeleton-associated protein 2-like OS=Homo sapiens OX=9606 GN=CKAP2L PE=1 SV=4 0 6.097 3 2 3 2 745 83.5 9.83 2 3 3307106.75 2 cytoplasm;cytoskeleton;cytosol Pf15297 150468 ENSG00000169607.12 CKAP2L 2 0 Medium Q0VGL1 Ragulator complex protein LAMTOR4 OS=Homo sapiens OX=9606 GN=LAMTOR4 PE=1 SV=1 0.016 1.679 11 1 3 1 99 10.7 6.54 1 1 1 2 6634710 3371404.5 1 1 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus membrane;vacuole protein binding;structural molecule activity 389541 ENSG00000188186.10 LAMTOR4 7 Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy mTOR signaling pathway 0 High P22528 Cornifin-B OS=Homo sapiens OX=9606 GN=SPRR1B PE=1 SV=2 0.001 3.285 34 2 3 2 89 9.9 8.48 2 3 1592729.5 1 cell death;cell differentiation;metabolic process cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity 6699 ENSG00000169469.8 SPRR1B 1 Formation of the cornified envelope 0 High Q96S16 JmjC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=JMJD8 PE=1 SV=2 0 5.665 11 3 3 3 264 29.5 6.64 3 3 104196.7358 5241166 4037138.813 2 1 3 0 High P18085 ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3 0 4.64 10 2 3 2 180 20.5 7.14 1 2 1 2 14324.33984 368119839.5 704018 8647824 1 2 1 2 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;Golgi;membrane catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 378 ENSG00000168374.10 ARF4 3 COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium; COPI-mediated anterograde transport 0 High Q9NXX6 Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2 0 16.115 12 3 3 3 385 44.3 5.38 3 3 5083093.875 3 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus protein binding "Pf08743, Pf15412" 54780 ENSG00000107672.14 NSMCE4A 10 SUMOylation of DNA damage response and repair proteins 0 High O75369 Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2 0 6.982 1 3 3 2 2602 278 5.73 3 3 768206.2188 280132.4297 2 2 cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding "Pf00307, Pf00630" 2317 ENSG00000136068.14 FLNB 3 ISG15 antiviral mechanism MAPK signaling pathway; Focal adhesion; Proteoglycans in cancer; Salmonella infection 0 High Q9UJU3 Zinc finger protein 112 OS=Homo sapiens OX=9606 GN=ZNF112 PE=1 SV=2 0 6.389 8 3 3 1 913 105.8 8.27 3 3 10692024 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 7771 ENSG00000062370.16 ZFP112; ZNF112 19 Generic Transcription Pathway 0 High Q96S52 GPI transamidase component PIG-S OS=Homo sapiens OX=9606 GN=PIGS PE=1 SV=3 0.001 4.052 4 2 3 2 555 61.6 6.49 1 2 1 2 7129260 1331313.75 1535488.375 1 1 2 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding Pf10510 94005 ENSG00000087111.20 PIGS 17 Attachment of GPI anchor to uPAR Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 High Q96K37 Solute carrier family 35 member E1 OS=Homo sapiens OX=9606 GN=SLC35E1 PE=1 SV=2 0 5.972 6 2 3 2 410 44.7 9.79 2 3 326077.625 1628381 462579.3125 1317143.906 1 1 1 2 transport Golgi;membrane "Pf03151, Pf08449" 79939 ENSG00000127526.14 SLC35E1 19 0 High Q9Y5S9 RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1 0 6.307 17 2 3 2 174 19.9 5.72 2 3 1159122 5565537.5 6991808.5 1 2 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 9939 ENSG00000265241.6 RBM8A; LOC101060541 1 mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Spliceosome; mRNA surveillance pathway; RNA transport 0 High Q32NC0 UPF0711 protein C18orf21 OS=Homo sapiens OX=9606 GN=C18ORF21 PE=1 SV=1 0 4.709 10 3 3 3 220 24.8 10.26 3 3 289266.75 11461864.75 1 3 83608 ENSG00000141428.16 C18orf21 18 0 High Q76FK4 Nucleolar protein 8 OS=Homo sapiens OX=9606 GN=NOL8 PE=1 SV=1 0 16.014 3 3 3 3 1167 131.5 7.09 3 3 3958710 2 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 55035 ENSG00000198000.11 NOL8 9 0 High O60684 Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1 0 5.024 4 2 3 1 536 60 4.98 2 1 2 1 94498.61719 1 regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding;transporter activity "Pf00514, Pf01749, Pf13513, Pf13646" 23633 ENSG00000025800.13 KPNA6 1 0 High Q9BZE1 "39S ribosomal protein L37, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" 0 13.344 8 2 3 2 423 48.1 8.59 1 2 1 2 685505.0625 1281153.125 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf07147 51253 ENSG00000116221.15 MRPL37 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q86UY6 N-alpha-acetyltransferase 40 OS=Homo sapiens OX=9606 GN=NAA40 PE=1 SV=1 0 5.652 10 2 3 2 237 27.2 7.39 2 3 2947866.719 2 cell organization and biogenesis;metabolic process cytoplasm;nucleus catalytic activity;protein binding Pf00583 79829 ENSG00000110583.12 NAA40 11 0 High P32322 "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" 0 6.815 7 2 3 2 319 33.3 7.61 2 1 2 1 1696847.625 1254307 1 1 metabolic process;regulation of biological process;response to stimulus mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf01210, Pf03807, Pf14748" 5831 ENSG00000183010.16 PYCR1 17 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 High Q15573 TATA box-binding protein-associated factor RNA polymerase I subunit A OS=Homo sapiens OX=9606 GN=TAF1A PE=1 SV=1 0 4.97 4 2 3 2 450 52.6 9.1 2 3 2012971.688 2 metabolic process;regulation of biological process cytoskeleton;nucleus DNA binding;protein binding Pf14929 9015 ENSG00000143498.17 TAF1A 1 SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation 0 High Q6IAN0 Dehydrogenase/reductase SDR family member 7B OS=Homo sapiens OX=9606 GN=DHRS7B PE=1 SV=2 0 5.023 7 3 3 3 325 35.1 9.55 3 3 1337380.75 4829927.406 1396610.156 1 2 3 metabolic process endoplasmic reticulum;membrane catalytic activity "Pf00106, Pf08659, Pf13460, Pf13561" 25979 ENSG00000109016.17 DHRS7B 17 0 High Q15904 V-type proton ATPase subunit S1 OS=Homo sapiens OX=9606 GN=ATP6AP1 PE=1 SV=2 0 9.107 9 3 3 3 470 52 6.14 3 3 745230.0625 193493.2656 3708131.25 1 1 3 cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding;transporter activity Pf05827 537 ENSG00000071553.16 ATP6AP1 X Transferrin endocytosis and recycling; Ion channel transport; Insulin receptor recycling Lysosome; Hepatitis B; Tuberculosis; Phagosome; Oxidative phosphorylation; Vibrio cholerae infection; Metabolic pathways; Epithelial cell signaling in Helicobacter pylori infection; Rheumatoid arthritis 0 High Q8NBP0 Tetratricopeptide repeat protein 13 OS=Homo sapiens OX=9606 GN=TTC13 PE=2 SV=3 0 5.333 3 2 3 2 860 96.8 7.01 1 2 1 2 1205388.625 898554.2813 1 2 protein binding "Pf00515, Pf07719, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559" 79573 ENSG00000143643.12 TTC13 1 0 High Q9Y6J9 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens OX=9606 GN=TAF6L PE=1 SV=1 0 10.106 7 3 3 3 622 67.8 8.97 3 3 2253415.938 2 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;protein binding "Pf02969, Pf07571" 10629 ENSG00000162227.7 TAF6L 11 HATs acetylate histones Basal transcription factors; Herpes simplex infection 0 High P49959 Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3 0 9.212 5 3 3 3 708 80.5 5.9 3 3 598747.5 2579665.813 1187497.438 1 3 2 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00149, Pf04152" 4361 ENSG00000020922.12 MRE11A; MRE11 11 G2/M DNA damage checkpoint; IRF3-mediated induction of type I IFN; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Non-homologous end-joining 0 High Q9NXE8 Pre-mRNA-splicing factor CWC25 homolog OS=Homo sapiens OX=9606 GN=CWC25 PE=1 SV=1 0.001 4.02 5 2 3 2 425 49.6 10.18 1 1 1 1 1 1 25145090 1891878.313 10417291 1 1 1 metabolic process "Pf10197, Pf12542" 54883 ENSG00000273559.4; ENSG00000276761.2 CWC25 17; CHR_HSCHR17_7_CTG4 mRNA Splicing - Major Pathway 0 High Q9Y2Q9 "28S ribosomal protein S28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" 0 10.496 15 3 3 3 187 20.8 9.1 3 3 831828.8047 57264746 56281.88281 2 3 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding "Pf00575, Pf10246" 28957 ENSG00000147586.9 MRPS28 8 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q03468 DNA excision repair protein ERCC-6 OS=Homo sapiens OX=9606 GN=ERCC6 PE=1 SV=1 0 13.651 3 3 3 3 1493 168.3 8.09 3 3 1097929.125 1 metabolic process;regulation of biological process;response to stimulus cytosol;Golgi;nucleus catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271" 2074 ENSG00000225830.12 ERCC6 10 Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; B-WICH complex positively regulates rRNA expression; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Transcription Initiation Nucleotide excision repair 0 High Q8NB90 ATPase family protein 2 homolog OS=Homo sapiens OX=9606 GN=SPATA5 PE=1 SV=3 0 10.756 5 3 3 3 893 97.8 5.66 2 1 2 1 996420 1925537.5 870819.1875 802496.0313 1 2 1 2 cell differentiation;development;metabolic process;response to stimulus cytoplasm;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf06414, Pf07724, Pf07726, Pf07728, Pf13173, Pf13191, Pf13401" 166378 ENSG00000145375.7 SPATA5 4 Ribosome biogenesis in eukaryotes 0 High P35222 Catenin beta-1 OS=Homo sapiens OX=9606 GN=CTNNB1 PE=1 SV=1 0 6.736 4 3 3 1 781 85.4 5.86 3 3 556630.9375 284527.6563 1 1 cell communication;cell differentiation;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;protein binding;signal transducer activity Pf00514 1499 ENSG00000168036.16 CTNNB1 3 "Beta-catenin phosphorylation cascade; CDO in myogenesis; Binding of TCF/LEF:CTNNB1 to target gene promoters; Apoptotic cleavage of cell adhesion proteins; RUNX3 regulates WNT signaling; S37 mutants of beta-catenin aren't phosphorylated; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Ca2+ pathway; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Misspliced GSK3beta mutants stabilize beta-catenin; Adherens junctions interactions; Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability" Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Hippo signaling pathway; Rap1 signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; HTLV-I infection; Melanogenesis; Wnt signaling pathway; Focal adhesion; Proteoglycans in cancer; Adherens junction; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Thyroid cancer; Basal cell carcinoma; Signaling pathways regulating pluripotency of stem cells 0 High O15213 WD repeat-containing protein 46 OS=Homo sapiens OX=9606 GN=WDR46 PE=1 SV=3 0 12.113 7 3 3 3 610 68 9.67 3 3 6484802.125 569563.5625 3 1 metabolic process nucleus protein binding;RNA binding "Pf00400, Pf08149" 9277 ENSG00000227057.9 WDR46 6 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q9BVQ7 Spermatogenesis-associated protein 5-like protein 1 OS=Homo sapiens OX=9606 GN=SPATA5L1 PE=1 SV=2 0 15.202 4 2 3 2 753 80.7 8.09 2 3 2395818.313 1 metabolic process;response to stimulus cytoplasm catalytic activity;nucleotide binding "Pf00004, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf13173, Pf13191, Pf13207, Pf13401, Pf13671" 79029 ENSG00000171763.18 SPATA5L1 15 0 High Q13523 Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRPF4B PE=1 SV=3 0 13.113 3 3 3 3 1007 116.9 10.26 3 3 2707865.375 2 metabolic process chromosome;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf07714" 8899 ENSG00000112739.16 PRPF4B 6 0 High Q9NQX3 Gephyrin OS=Homo sapiens OX=9606 GN=GPHN PE=1 SV=1 0.003 2.632 2 2 3 2 736 79.7 5.43 2 3 842499.1563 2 cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00994, Pf03453, Pf03454" 10243 ENSG00000171723.15 GPHN 14 Molybdenum cofactor biosynthesis Folate biosynthesis; GABAergic synapse; Metabolic pathways 0 High Q16540 "39S ribosomal protein L23, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL23 PE=1 SV=1" 0 8.703 20 3 3 3 153 17.8 9.69 3 3 687543.6875 12895947.5 2018226.25 1 2 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00276 6150 ENSG00000214026.10 MRPL23 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P26583 High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2 0 5.387 11 2 3 1 209 24 7.81 2 3 Met-loss [N-Term] cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;extracellular;nucleus DNA binding;protein binding;RNA binding "Pf00505, Pf09011" 3148 ENSG00000164104.11 HMGB2 4 Activation of DNA fragmentation factor 0 Low Q5W0U4 B box and SPRY domain-containing protein OS=Homo sapiens OX=9606 GN=BSPRY PE=2 SV=1 0.071 0.909 1 1 3 1 402 44.4 6.42 1 3 25362150 1 transport cytoplasm;membrane metal ion binding;protein binding "Pf00622, Pf13765" 54836 ENSG00000119411.10 BSPRY 9 0 High Q8TBK6 Zinc finger CCHC domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZCCHC10 PE=1 SV=1 0 4.956 7 1 3 1 192 21 8.53 1 1 2 1 2818807.5 1609673.875 1 1 metal ion binding;protein binding Pf13917 54819 ENSG00000155329.11 ZCCHC10 5 0 High O43776 "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS PE=1 SV=1" 0 9.387 6 3 3 3 548 62.9 6.25 2 1 2 1 720916.5625 7522410.719 610150.25 422265.2188 1 2 1 1 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding "Pf00152, Pf01336" 4677 ENSG00000134440.11 NARS 18 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q99551 "Transcription termination factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF1 PE=1 SV=1" 0 8.27 7 3 3 3 399 45.7 9.42 3 3 3244400.75 2 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;mitochondrion;organelle lumen DNA binding;protein binding;RNA binding Pf02536 7978 ENSG00000127989.13 MTERF; MTERF1 7 Transcriptional activation of mitochondrial biogenesis; Mitochondrial transcription termination 0 High Q9UMR5 Lysosomal thioesterase PPT2 OS=Homo sapiens OX=9606 GN=PPT2 PE=1 SV=4 0 9.077 14 3 3 3 302 34.2 6.33 3 3 3000933.75 451602.2969 1890638.188 1 2 3 metabolic process organelle lumen;vacuole catalytic activity "Pf00561, Pf02089, Pf12697" 9374 ENSG00000221988.12 PPT2 6 Fatty acyl-CoA biosynthesis Lysosome; Fatty acid elongation; Metabolic pathways; Fatty acid metabolism 0 High O75487 Glypican-4 OS=Homo sapiens OX=9606 GN=GPC4 PE=1 SV=4 0 9.932 9 3 3 3 556 62.4 6.68 1 2 1 2 1293742.125 1390676.375 1287761.359 1 1 3 cell proliferation;metabolic process;regulation of biological process;response to stimulus extracellular;membrane;nucleus;organelle lumen protein binding Pf01153 2239 ENSG00000076716.8 GPC4 X "Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Defective B4GALT7 causes EDS, progeroid type; Retinoid metabolism and transport; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective EXT2 causes exostoses 2; Defective B3GAT3 causes JDSSDHD; Defective EXT1 causes exostoses 1, TRPS2 and CHDS" Wnt signaling pathway 0 High O95347 Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2 0 5.76 3 3 3 3 1197 135.6 8.43 1 1 1 1 1 1 6241423.75 794166.625 598712.9375 2 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf01576, Pf02463, Pf04111, Pf05262, Pf05622, Pf06470, Pf08317, Pf09726, Pf09731, Pf10174, Pf10186, Pf12128, Pf12718, Pf13166, Pf13175, Pf13304, Pf13476, Pf13555, Pf13863, Pf14362, Pf15619" 10592 ENSG00000136824.18 SMC2 9 Condensation of Prometaphase Chromosomes; Condensation of Prophase Chromosomes 0 High Q9BYD2 "39S ribosomal protein L9, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" 0 14.378 9 2 3 2 267 30.2 10.08 2 3 14077516.75 418244.625 2 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf01281 65005 ENSG00000143436.10 MRPL9 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9NUQ3 Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2 0 8.913 8 3 3 3 528 60.5 7.52 3 3 1824970.5 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding Pf09728 55787 ENSG00000086712.12 TXLNG X 0 High Q92530 Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2 0 8.112 12 2 3 2 271 29.8 5.74 2 1 2 1 1141711.375 1664556.406 1243435.891 1 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;proteasome enzyme regulator activity;protein binding "Pf08577, Pf11566" 9491 ENSG00000125818.17 PSMF1 20 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q9BUT9 MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2 0 19.745 42 3 3 3 160 17.8 9.41 3 3 2773993.75 108871.9453 917851.4082 2 1 2 cytoplasm;nucleus protein binding Pf14799 84331 ENSG00000172366.19 FAM195A; MCRIP2 16 0 High Q96RS0 Trimethylguanosine synthase OS=Homo sapiens OX=9606 GN=TGS1 PE=1 SV=3 0 18.758 6 3 3 3 853 96.6 4.94 3 3 1743771.125 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00107, Pf01170, Pf02475, Pf03602, Pf04445, Pf06325, Pf08241, Pf08242, Pf09445, Pf12847, Pf13649, Pf13659, Pf13847" 96764 ENSG00000137574.10 TGS1 8 "Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; snRNP Assembly; RORA activates gene expression; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription" RNA transport 0 High Q9UG56 "Phosphatidylserine decarboxylase proenzyme, mitochondrial OS=Homo sapiens OX=9606 GN=PISD PE=2 SV=4" 0 6.87 5 2 3 2 409 46.6 9.42 2 3 725233.6875 1 metabolic process membrane;mitochondrion;nucleus catalytic activity Pf02666 23761 ENSG00000241878.11 PISD 22 Synthesis of PE Glycerophospholipid metabolism; Metabolic pathways 0 High Q9BX10 GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=GTPBP2 PE=1 SV=1 0 12.532 5 3 3 3 602 65.7 8.05 3 3 9278496.25 422668 3 1 transport extracellular;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00009, Pf03143" 54676 ENSG00000172432.18 GTPBP2 6 Platelet degranulation 0 High Q9BYD3 "39S ribosomal protein L4, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" 0 13.582 14 3 3 3 311 34.9 9.72 3 3 7608434.875 270170 3 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00573 51073 ENSG00000105364.13 MRPL4 19 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q86Y79 Probable peptidyl-tRNA hydrolase OS=Homo sapiens OX=9606 GN=PTRH1 PE=1 SV=1 0 12.962 11 2 3 2 214 22.9 10.56 2 3 5301314.875 2 mitochondrion catalytic activity;protein binding;RNA binding Pf01195 138428 ENSG00000187024.13 PTRH1 9 0 High Q96JN8 Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2 0 7.173 2 3 3 3 1562 166.8 5.86 1 1 1 1 1 1 505312.2188 530044.4375 1 2 cytoplasm;cytoskeleton protein binding Pf07177 84461 ENSG00000215041.9 NEURL4 17 0 High P52907 F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3 0 6.159 9 2 3 2 286 32.9 5.69 1 1 1 1 1 1 217450.1094 2990613.25 783636.125 377521.5313 1 1 1 1 cell organization and biogenesis;cellular component movement;coagulation;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular protein binding Pf01267 829 ENSG00000116489.12 CAPZA1 1 COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Advanced glycosylation endproduct receptor signaling; Factors involved in megakaryocyte development and platelet production; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Interleukin-12 family signaling Endocytosis 0 High Q7Z4S6 Kinesin-like protein KIF21A OS=Homo sapiens OX=9606 GN=KIF21A PE=1 SV=2 0.001 3.402 2 2 3 1 1674 187.1 6.42 1 1 1 1 1 1 171374.8438 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00038, Pf00225, Pf00400, Pf00769, Pf01576, Pf02050, Pf02463, Pf02841, Pf02996, Pf03938, Pf03962, Pf04111, Pf05010, Pf05483, Pf05557, Pf05622, Pf07926, Pf09731, Pf10174, Pf10211, Pf11600, Pf12037, Pf12128, Pf12718, Pf13166, Pf13514, Pf13863, Pf13868, Pf14943, Pf14988, Pf15558, Pf15619" 55605 ENSG00000139116.18 KIF21A 12 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins 0 High P49841 Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2 0.002 2.898 7 2 3 2 420 46.7 8.78 2 3 1865916.375 1538234.375 1960592.656 1 1 2 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714, Pf14531" 2932 ENSG00000082701.14 GSK3B 3 Regulation of RUNX2 expression and activity; AKT phosphorylates targets in the cytosol; S37 mutants of beta-catenin aren't phosphorylated; Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; S33 mutants of beta-catenin aren't phosphorylated; CRMPs in Sema3A signaling; Regulation of HSF1-mediated heat shock response; Disassembly of the destruction complex and recruitment of AXIN to the membrane; APC truncation mutants have impaired AXIN binding; S45 mutants of beta-catenin aren't phosphorylated; GLI3 is processed to GLI3R by the proteasome; Misspliced GSK3beta mutants stabilize beta-catenin; Constitutive Signaling by AKT1 E17K in Cancer; Degradation of GLI2 by the proteasome; T41 mutants of beta-catenin aren't phosphorylated; B-WICH complex positively regulates rRNA expression; Truncations of AMER1 destabilize the destruction complex Dopaminergic synapse; T cell receptor signaling pathway; Insulin signaling pathway; Prolactin signaling pathway; Epstein-Barr virus infection; Neurotrophin signaling pathway; B cell receptor signaling pathway; Hippo signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; EGFR tyrosine kinase inhibitor resistance; HTLV-I infection; Melanogenesis; Wnt signaling pathway; Focal adhesion; Alzheimer's disease; mTOR signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Hedgehog signaling pathway; Measles; Hepatitis C; Cell cycle; Chemokine signaling pathway; Axon guidance; Basal cell carcinoma; Signaling pathways regulating pluripotency of stem cells; Influenza A; Insulin resistance; PI3K-Akt signaling pathway 0 High Q969H0 F-box/WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=FBXW7 PE=1 SV=1 0 5.676 5 3 3 3 707 79.6 5.8 2 1 2 1 226348.9844 2065854 2555785.75 1510657.344 1 2 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;protein binding "Pf00400, Pf00646, Pf12937" 55294 ENSG00000109670.13 FBXW7 4 Regulation of RUNX2 expression and activity; NOTCH1 Intracellular Domain Regulates Transcription; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Ubiquitin mediated proteolysis 0 High P13667 Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2 0 11.473 5 3 3 3 645 72.9 5.07 3 3 441890.4688 4352449.438 1 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;organelle lumen catalytic activity;metal ion binding;protein binding;RNA binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13905" 9601 ENSG00000155660.10 PDIA4 7 Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Vibrio cholerae infection 0 High Q6UXM1 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens OX=9606 GN=LRIG3 PE=2 SV=1 0 7.022 3 3 3 2 1119 123.4 6.19 3 3 213808 328536.1875 1 1 development membrane protein binding "Pf00047, Pf07679, Pf12799, Pf13306, Pf13855, Pf13895, Pf13927" 121227 ENSG00000139263.11 LRIG3 12 0 High Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3 0 14.583 6 3 3 3 755 81.4 7.74 3 3 156924467.5 3 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00643, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227" 81844 ENSG00000169871.12 TRIM56 7 Regulation of innate immune responses to cytosolic DNA 0 High Q8NI27 THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2 0 7.022 1 2 3 2 1593 182.7 8.44 2 1 2 1 3375083.625 390372.6875 106206.9375 2 1 1 Met-loss+Acetyl [N-Term] cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport nucleus protein binding;RNA binding "Pf11262, Pf11732" 57187 ENSG00000125676.19 THOC2 X Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing Spliceosome; RNA transport 0 High Q69YQ0 Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=2 0 9.415 3 3 3 3 1117 124.5 5.72 1 1 1 1 1 1 253845.125 1187599.375 1 1 cell division;metabolic process cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity "Pf00038, Pf00307, Pf01920, Pf02463, Pf03251, Pf04111, Pf04156, Pf05667, Pf05701, Pf08317, Pf11971, Pf12128, Pf13166" 23384 SPECC1L 22 0 High A6NFI3 Zinc finger protein 316 OS=Homo sapiens OX=9606 GN=ZNF316 PE=1 SV=1 0 7.275 4 2 3 2 1004 108.4 5.31 2 3 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 100131017 ENSG00000205903.6 ZNF316 7 0 High Q8NDD1 Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1ORF131 PE=1 SV=4 0 8.016 10 3 3 3 293 32.6 9.88 3 3 5195929.781 3 0 High P14174 Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4 0 5.662 18 2 3 2 115 12.5 7.88 2 1 2 1 2010025.313 1082269.75 2 1 Met-loss [N-Term] cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;extracellular;organelle lumen catalytic activity;protein binding Pf01187 4282 ENSG00000276701.2; ENSG00000240972.1 MIF 22; CHR_HSCHR22_1_CTG7 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Neutrophil degranulation; Interleukin-12 family signaling; Cell surface interactions at the vascular wall Tyrosine metabolism; Phenylalanine metabolism 0 High Q9NSB2 "Keratin, type II cuticular Hb4 OS=Homo sapiens OX=9606 GN=KRT84 PE=2 SV=2" 0 4.856 4 2 3 1 600 64.8 7.56 1 1 1 1 1 1 1730120.75 915489.1875 1 1 cell death;cell organization and biogenesis;regulation of biological process cytoskeleton;cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf05557, Pf09726, Pf09728, Pf13514" 3890 ENSG00000161849.3 KRT84 12 Formation of the cornified envelope 0 High P35998 26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3 0 4.469 5 2 3 2 433 48.6 5.95 1 2 1 2 6448740.906 834947.6875 1163729.094 2 1 2 cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00158, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401" 5701 ENSG00000161057.11 PSMC2 7 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 High Q96F86 Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1 0 11.872 11 3 3 3 508 56 7.11 1 2 1 2 426691.4063 918565.375 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane catalytic activity;protein binding;RNA binding "Pf03853, Pf09532, Pf12701" 80153 ENSG00000179151.11 EDC3 15 mRNA decay by 5' to 3' exoribonuclease RNA degradation 0 High P27797 Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1 0 7.723 9 3 3 3 417 48.1 4.44 3 3 2424353.471 374706.3125 2879782.063 2 1 3 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus;organelle lumen DNA binding;metal ion binding;protein binding;RNA binding Pf00262 811 ENSG00000179218.13 CALR 19 "Scavenging by Class F Receptors; Assembly of Viral Components at the Budding Site; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway; Calnexin/calreticulin cycle; Scavenging by Class A Receptors" Chagas disease (American trypanosomiasis); Protein processing in endoplasmic reticulum; HTLV-I infection; Phagosome; Antigen processing and presentation 0 High Q9ULX6 A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4 0 12.51 5 3 3 3 646 71.6 5.05 2 1 2 1 322030.9922 14913161.25 727601.875 471950.5313 2 3 1 1 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding Pf04988 26993 ENSG00000011243.17 AKAP8L 19 Epstein-Barr virus infection 0 High Q14004 Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2 0 8.106 2 3 3 2 1512 164.8 9.69 2 1 2 1 2734069.563 2 cell division;development;metabolic process;regulation of biological process;transport chromosome;cytosol;extracellular;Golgi;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00069, Pf07714" 8621 ENSG00000065883.14 CDK13 7 Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes 0 High P53618 Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3 0 7.709 4 2 3 2 953 107.1 6.05 2 1 2 1 1387992.125 548577.375 2 1 transport cytoplasm;cytosol;Golgi;membrane protein binding;structural molecule activity "Pf01602, Pf07718, Pf14806" 1315 ENSG00000129083.12 COPB1 11 COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation; COPI-mediated anterograde transport 0 High P53396 ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3 0 6.961 3 3 3 3 1101 120.8 7.33 1 2 1 2 409450.2813 4941246.469 440994.5625 174439.7813 1 2 1 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00285, Pf00549, Pf02629, Pf08442" 47 ENSG00000131473.16 ACLY 17 ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Neutrophil degranulation Citrate cycle (TCA cycle); Metabolic pathways 0 High Q9P015 "39S ribosomal protein L15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" 0 11.898 12 3 3 3 296 33.4 10.01 3 3 8423383.75 519439.1875 3 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00828 29088 ENSG00000137547.8 MRPL15 8 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High O60232 Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1 0 6.199 22 2 3 2 199 21.5 5.24 1 1 2 1 439621.5313 947517.4375 8517154.188 2 1 2 cell division protein binding Pf06677 10534 ENSG00000173465.7 SSSCA1 11 0 High Q9NPA3 Mid1-interacting protein 1 OS=Homo sapiens OX=9606 GN=MID1IP1 PE=1 SV=1 0.003 2.628 9 2 3 2 183 20.2 5.5 2 3 1484620.5 34013920.5 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus protein binding Pf07084 58526 ENSG00000165175.15 MID1IP1 X Import of palmitoyl-CoA into the mitochondrial matrix 0 High Q02083 N-acylethanolamine-hydrolyzing acid amidase OS=Homo sapiens OX=9606 GN=NAAA PE=1 SV=3 0 5.183 7 3 3 3 359 40 8.75 3 3 4859748.438 1844157.219 2 3 metabolic process;transport cytoplasm;organelle lumen;vacuole catalytic activity;protein binding "Pf02275, Pf15508" 27163 ENSG00000138744.14 NAAA 4 Neurotransmitter release cycle 0 High Q9Y679 Ancient ubiquitous protein 1 OS=Homo sapiens OX=9606 GN=AUP1 PE=1 SV=2 0 9.17 7 3 3 3 410 45.8 8.65 3 3 643214.75 1068733.656 1730981.563 1 2 2 0 High Q99543 DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4 0 9.571 7 3 3 3 621 72 8.7 3 3 156344439.6 602092.875 587213.9375 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;enzyme regulator activity;protein binding;RNA binding "Pf00226, Pf00249" 27000 ENSG00000105821.14 DNAJC2 7 Regulation of HSF1-mediated heat shock response 0 Medium A0A075B6S5 Immunoglobulin kappa variable 1-27 OS=Homo sapiens OX=9606 GN=IGKV1-27 PE=3 SV=1 0.013 1.817 14 1 3 1 117 12.7 8.29 1 1 1 1 1 1 813122.625 994359.75 2549316.5 1 1 1 response to stimulus extracellular;membrane "Pf00047, Pf07679, Pf07686, Pf13927" 28935 ENSG00000282666.1; ENSG00000244575.3 IGKV1-27 CHR_HG2290_PATCH; 2 0 High Q9BQA1 Methylosome protein 50 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1 0 8.49 9 2 3 2 342 36.7 5.17 2 1 2 1 62006.51172 5311682.5 701264.625 1 2 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding Pf00400 79084 ENSG00000116455.13 WDR77 1 snRNP Assembly; RMTs methylate histone arginines 0 High Q9ULH1 "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4" 0 8.382 3 3 3 3 1129 125.4 7.31 3 3 2578525.313 1303255.656 3 3 cell organization and biogenesis;regulation of biological process cytoplasm;cytosol;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00018, Pf00023, Pf00169, Pf01412, Pf12796, Pf13637, Pf13857, Pf14604" 50807 ENSG00000153317.14 ASAP1 8 VxPx cargo-targeting to cilium Endocytosis; Fc gamma R-mediated phagocytosis 0 High Q9UH62 Armadillo repeat-containing X-linked protein 3 OS=Homo sapiens OX=9606 GN=ARMCX3 PE=1 SV=1 0 10.913 11 3 3 3 379 42.5 8.37 3 3 4379405.75 906823 1032749.5 2 1 1 regulation of biological process cytoplasm;membrane;mitochondrion;nucleus protein binding "Pf04826, Pf09759" 51566 ENSG00000102401.19 ARMCX3 X 0 High Q9Y241 "HIG1 domain family member 1A, mitochondrial OS=Homo sapiens OX=9606 GN=HIGD1A PE=1 SV=1" 0 7.972 30 2 3 2 93 10.1 9.79 1 2 1 2 656542.6875 1492001.375 2757770.406 1 1 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion Pf04588 25994 ENSG00000181061.13 HIGD1A 3 Regulation of gene expression by Hypoxia-inducible Factor 0 High Q09666 Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2 0 7.599 5 3 3 3 5890 628.7 6.15 2 1 2 1 1236625.313 3844244.75 2907453.031 972509.875 2 1 3 3 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding;structural molecule activity 79026 ENSG00000124942.13 AHNAK 11 0 High Q969H6 Ribonuclease P/MRP protein subunit POP5 OS=Homo sapiens OX=9606 GN=POP5 PE=1 SV=1 0 15.226 27 3 3 3 163 18.8 7.27 3 3 7719983.75 181546.7188 2 1 metabolic process;transport nucleus catalytic activity;protein binding;transporter activity Pf00999 51367 ENSG00000167272.10 POP5 12 tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High P35030 Trypsin-3 OS=Homo sapiens OX=9606 GN=PRSS3 PE=1 SV=2 0 4.371 4 1 3 1 304 32.5 7.49 1 1 2 1 2858319.25 4172292 2761798.25 1 1 1 cellular component movement;metabolic process;response to stimulus;transport extracellular catalytic activity;metal ion binding;protein binding Pf00089 5646 ENSG00000010438.16 PRSS3 9 "Alpha-defensins; Cobalamin (Cbl, vitamin B12) transport and metabolism; Neutrophil degranulation" Neuroactive ligand-receptor interaction; Protein digestion and absorption; Pancreatic secretion; Influenza A 0 High Q92521 GPI mannosyltransferase 3 OS=Homo sapiens OX=9606 GN=PIGB PE=1 SV=1 0 7.902 6 3 3 3 554 65 9.29 3 3 2664259.563 1421594 1581328.5 2 1 3 metabolic process endoplasmic reticulum;membrane catalytic activity Pf03901 9488 ENSG00000069943.9 PIGB 15 Synthesis of glycosylphosphatidylinositol (GPI) Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 High Q13685 Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2 0 10.066 9 3 3 3 434 46.7 4.42 2 1 2 1 2322773.5 753646.4375 1 1 cell differentiation;cellular component movement;development;regulation of biological process cell surface;cytoplasm;cytoskeleton;cytosol;membrane protein binding "Pf00400, Pf14134" 14 ENSG00000127837.9 AAMP 2 0 High Q6P3R8 Serine/threonine-protein kinase Nek5 OS=Homo sapiens OX=9606 GN=NEK5 PE=2 SV=1 0 7.29 3 1 3 1 708 81.4 8.87 1 1 1 2 11452640 12264752 1 1 metabolic process;regulation of biological process catalytic activity;metal ion binding;nucleotide binding "Pf00069, Pf07714, Pf14531" 341676 ENSG00000197168.11 NEK5 13 0 High O94992 Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1 0 9.37 7 2 3 2 359 40.6 4.89 2 3 4244170.5 2 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus enzyme regulator activity;protein binding;RNA binding Pf15313 10614 ENSG00000186834.3 HEXIM1 17 0 High Q92576 PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3 0 8.193 3 3 3 3 2039 229.3 6.96 3 3 79509.69531 1702812.25 1 2 development;metabolic process metal ion binding;protein binding "Pf00628, Pf07500, Pf07744" 23469 ENSG00000118482.11 PHF3 6 0 High Q92542 Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2 0 7.144 4 3 3 3 709 78.4 5.99 3 3 10173741.75 2444270.594 4264485.25 2 2 3 cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;Golgi;membrane catalytic activity;protein binding Pf05450 23385 ENSG00000162736.15 NCSTN 1 Activated NOTCH1 Transmits Signal to the Nucleus; Signaling by NOTCH4; Regulated proteolysis of p75NTR; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NRIF signals cell death from the nucleus; Signaling by NOTCH3; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of the extracellular matrix; Neutrophil degranulation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Nuclear signaling by ERBB4; Signalling by NGF Alzheimer's disease; Notch signaling pathway 0 High Q9UBU8 Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2 0 11.336 9 3 3 3 362 41.4 9.28 3 3 9525126.625 481823.5313 98620.9375 3 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus nucleus protein binding "Pf05712, Pf11717" 10933 ENSG00000185787.14 MORF4L1 15 HATs acetylate histones 0 High Q96PU8 Protein quaking OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1 0 9.62 7 3 3 3 341 37.6 8.56 2 1 2 1 973612.9375 2306703.25 3661604.25 630061.625 1 2 2 1 cell differentiation;development;metabolic process;regulation of biological process;transport cytoplasm;nucleus protein binding;RNA binding "Pf00013, Pf13014" 9444 ENSG00000112531.16 QKI 6 Signaling by BRAF and RAF fusions 0 High P10253 Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4 0 5.774 3 3 3 2 952 105.3 6 3 3 9885358.938 5896716 1433845.438 1305946.031 2 1 3 3 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport membrane;organelle lumen;vacuole catalytic activity "Pf00088, Pf01055, Pf13802" 2548 ENSG00000171298.12 GAA 17 Neutrophil degranulation; Glycogen storage disease type II (GAA); Lysosomal glycogen catabolism; Glycogen breakdown (glycogenolysis) Lysosome; Galactose metabolism; Starch and sucrose metabolism; Metabolic pathways 1 High Q9P1U0 DNA-directed RNA polymerase I subunit RPA12 OS=Homo sapiens OX=9606 GN=ZNRD1 PE=2 SV=1 0 8.132 37 3 3 3 126 13.9 5.06 2 1 2 1 710595.1875 2915858.75 914475.3125 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;metal ion binding "Pf01096, Pf07282" 30834 ENSG00000066379.14; ENSG00000224859.6; ENSG00000236808.6; ENSG00000235443.6; ENSG00000235176.6; ENSG00000236949.6; ENSG00000233795.6; ENSG00000206502.8 ZNRD1 6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_QBL_CTG1 RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation Purine metabolism; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High P02042 Hemoglobin subunit delta OS=Homo sapiens OX=9606 GN=HBD PE=1 SV=2 0 6.256 21 3 3 3 147 16 8.05 2 1 2 1 12464108.38 4159.307617 519081.8125 2 1 1 coagulation;transport cytosol metal ion binding;protein binding;transporter activity Pf00042 3045 ENSG00000223609.7 HBD 11 Factors involved in megakaryocyte development and platelet production 0 Medium Q8IZK6 Mucolipin-2 OS=Homo sapiens OX=9606 GN=MCOLN2 PE=1 SV=2 0.017 1.652 1 1 3 1 566 65.9 7.61 1 1 2 1 6952589.625 3794807.5 1 1 cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport endosome;membrane;vacuole transporter activity "Pf00520, Pf08016" 255231 ENSG00000153898.12 MCOLN2 1 TRP channels 0 High Q96TC7 Regulator of microtubule dynamics protein 3 OS=Homo sapiens OX=9606 GN=RMDN3 PE=1 SV=2 0.001 4.032 4 2 2 2 470 52.1 5.1 2 2 1269516.375 1012027.375 3371.471924 2 1 1 cell death;cell differentiation;cellular homeostasis cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus protein binding 55177 ENSG00000137824.15 FAM82A2; RMDN3 15 0 High O43791 Speckle-type POZ protein OS=Homo sapiens OX=9606 GN=SPOP PE=1 SV=1 0 5.85 6 2 2 2 374 42.1 5.8 2 2 3231919.75 609151.5 2 1 metabolic process;regulation of biological process cytoplasm;nucleus protein binding "Pf00651, Pf00917" 8405 ENSG00000121067.17 SPOP 17 Hedgehog 'on' state Hedgehog signaling pathway 0 High P41208 Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1 0 8.625 17 2 2 2 172 19.7 5 2 2 5605066.5 113953.9922 2 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;nucleus metal ion binding;protein binding "Pf00036, Pf13202, Pf13405, Pf13499, Pf13833" 1069 ENSG00000147400.8 CETN2 X Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; SUMOylation of DNA damage response and repair proteins Nucleotide excision repair 0 High Q5T6F2 Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1 0.002 2.822 2 2 2 2 1119 117 7.34 2 2 198385.2344 1297198.375 1 1 regulation of biological process cytoplasm;nucleus protein binding;RNA binding "Pf00627, Pf12478, Pf14555" 55833 ENSG00000137073.21 UBAP2 9 0 High Q96IX5 "ATP synthase membrane subunit DAPIT, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MD PE=1 SV=1" 0 5.543 28 1 2 1 58 6.5 9.76 1 1 1 1 1853899.25 2246409.75 1 1 Met-loss [N-Term] membrane;mitochondrion Pf14960 84833 ENSG00000173915.14 USMG5 10 0 High P13671 Complement component C6 OS=Homo sapiens OX=9606 GN=C6 PE=1 SV=3 0 5.032 1 1 2 1 934 104.7 6.76 1 1 1 1 2087322.75 1471576.875 830013.6875 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular protein binding "Pf00057, Pf00084, Pf00090, Pf01823" 729 ENSG00000039537.13 C6 5 Terminal pathway of complement; Regulation of Complement cascade Prion diseases; Complement and coagulation cascades; Systemic lupus erythematosus 0 High P25789 Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1 0.003 2.744 7 2 2 2 261 29.5 7.72 2 2 382226.6875 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;protein binding "Pf00227, Pf10584" 5685 ENSG00000041357.15 PSMA4 15 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q9Y4K0 Lysyl oxidase homolog 2 OS=Homo sapiens OX=9606 GN=LOXL2 PE=1 SV=1 0.001 4.138 3 1 2 1 774 86.7 6.38 1 1 1 1 549202.875 463342.0938 1 1 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;extracellular;membrane;nucleus catalytic activity;metal ion binding;protein binding;receptor activity "Pf00530, Pf01186" 4017 ENSG00000134013.15 LOXL2 8 Elastic fibre formation; Crosslinking of collagen fibrils 0 High P78549 Endonuclease III-like protein 1 OS=Homo sapiens OX=9606 GN=NTHL1 PE=1 SV=2 0.002 2.898 3 1 2 1 312 34.4 9.67 1 2 19784312 2782988.75 206173.8438 95658.30469 1 1 1 1 metabolic process;response to stimulus mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00633, Pf00730" 4913 ENSG00000065057.7 NTHL1 16 Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1 Base excision repair 0 High Q9Y4A8 Nuclear factor erythroid 2-related factor 3 OS=Homo sapiens OX=9606 GN=NFE2L3 PE=1 SV=1 0.003 2.716 7 2 2 2 694 76.1 5.44 1 1 1 1 435697.4063 1 metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf07716" 9603 ENSG00000050344.8 NFE2L3 7 0 High P40616 ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1 0 6.442 13 2 2 2 181 20.4 5.72 2 2 543098.9375 863317.8125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 400 ENSG00000120805.13 ARL1 12 Retrograde transport at the Trans-Golgi-Network 0 High Q9H1A4 Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1 0 9.543 2 2 2 2 1944 216.4 6.3 2 2 844620.125 761231.2969 36652.50781 1 2 1 cell division;metabolic process;regulation of biological process cytosol;nucleus "Pf01851, Pf12859" 64682 ENSG00000153107.11 ANAPC1 2 APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP) Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 High Q9BRR0 Zinc finger protein with KRAB and SCAN domains 3 OS=Homo sapiens OX=9606 GN=ZKSCAN3 PE=1 SV=2 0 4.782 6 2 2 1 538 60.6 6.4 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf02023, Pf13465" 80317 ENSG00000189298.13 ZKSCAN3 6 Generic Transcription Pathway 0 High Q9H6Y2 WD repeat-containing protein 55 OS=Homo sapiens OX=9606 GN=WDR55 PE=1 SV=2 0 15.81 8 2 2 2 383 42 4.92 2 2 369982.3438 3431850.5 802384.5625 3143766.25 1 2 1 1 metabolic process cytoplasm;nucleus protein binding Pf00400 54853 ENSG00000120314.18 WDR55 5 0 High Q92796 Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2 0 4.666 4 2 2 2 817 90.3 7.03 2 2 834021.4375 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane catalytic activity;protein binding;transporter activity "Pf00018, Pf00595, Pf00625, Pf07653, Pf10368, Pf10600, Pf13180" 1741 ENSG00000082458.11 DLG3 X NrCAM interactions; Synaptic adhesion-like molecules; Activation of Ca-permeable Kainate Receptor; Neurexins and neuroligins Hippo signaling pathway 0 High Q8IYU8 "Calcium uptake protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=MICU2 PE=1 SV=2" 0 14.753 9 2 2 2 434 49.6 9.09 2 2 4376302 2 cellular homeostasis;transport membrane;mitochondrion;nucleus metal ion binding;protein binding Pf13833 221154 ENSG00000165487.13 EFHA1; MICU2 13 Processing of SMDT1 0 High P53597 "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" 0 5.762 7 2 2 2 346 36.2 8.79 1 1 1 1 2031459 1071857.375 582392.1875 1 1 1 metabolic process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;RNA binding "Pf00549, Pf02629, Pf13607" 8802 ENSG00000163541.11 SUCLG1 2 Citric acid cycle (TCA cycle) Propanoate metabolism; Citrate cycle (TCA cycle); Carbon metabolism; Metabolic pathways 0 High Q96C36 Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1 0 4.306 9 2 2 2 320 33.6 7.77 1 1 1 1 718600.9844 488790.9375 741183.9375 719201.4375 2 1 1 1 metabolic process;response to stimulus cytoplasm;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf01210, Pf03807, Pf14748" 29920 ENSG00000143811.18 PYCR2 1 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 High Q86U86 Protein polybromo-1 OS=Homo sapiens OX=9606 GN=PBRM1 PE=1 SV=1 0 6.961 1 2 2 2 1689 192.8 6.89 2 2 232199.4219 7827163.75 1 2 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00439, Pf00505, Pf01426" 55193 ENSG00000163939.18 PBRM1 3 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q8IXK0 Polyhomeotic-like protein 2 OS=Homo sapiens OX=9606 GN=PHC2 PE=1 SV=1 0 5.949 2 2 2 2 858 90.7 8.69 2 2 47409.625 17933414.25 1 2 development nucleus DNA binding;metal ion binding;protein binding "Pf00536, Pf07647" 1912 ENSG00000134686.18 PHC2 1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins 0 High Q8TED1 Probable glutathione peroxidase 8 OS=Homo sapiens OX=9606 GN=GPX8 PE=1 SV=2 0 4.565 9 2 2 2 209 23.9 9.35 2 2 137610.1406 2490205.063 1 2 metabolic process;response to stimulus membrane;organelle lumen antioxidant activity;catalytic activity "Pf00255, Pf00578" 493869 ENSG00000164294.13 GPX8 5 Detoxification of Reactive Oxygen Species Glutathione metabolism; Arachidonic acid metabolism; Thyroid hormone synthesis 0 High Q96J02 E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2 0 4.326 2 2 2 2 903 102.7 6.3 1 1 1 1 1086558.75 763729.8125 196029.5313 1 2 1 cell death;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;membrane;nucleus catalytic activity;protein binding "Pf00168, Pf00397, Pf00632" 83737 ENSG00000078747.14 ITCH 20 Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; Degradation of GLI1 by the proteasome; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB4 signaling Endocytosis; TNF signaling pathway; Ubiquitin mediated proteolysis; Non-alcoholic fatty liver disease (NAFLD) 0 High P67812 Signal peptidase complex catalytic subunit SEC11A OS=Homo sapiens OX=9606 GN=SEC11A PE=1 SV=1 0 4.521 9 2 2 2 179 20.6 9.48 2 2 945483.5 199873.1406 1998878 1 1 2 metabolic process endoplasmic reticulum;membrane catalytic activity Pf00717 23478 ENSG00000140612.13 SEC11A 15 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)" Protein export 0 High Q9UHA2 SS18-like protein 2 OS=Homo sapiens OX=9606 GN=SS18L2 PE=3 SV=1 0.002 2.775 14 1 2 1 77 8.8 5.83 1 2 1037452.5 1448114 1139.649414 1 1 1 Met-loss+Acetyl [N-Term] regulation of biological process Pf05030 51188 ENSG00000008324.11 SS18L2 3 0 High O60563 Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1 0 7.536 5 2 2 2 726 80.6 8.78 2 2 1054981.25 1 cell division;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding Pf00134 904 ENSG00000129315.10 CCNT1 12 RNA polymerase II transcribes snRNA genes; Interactions of Tat with host cellular proteins; Tat-mediated HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation Transcriptional misregulation in cancer 0 High Q96JB3 Hypermethylated in cancer 2 protein OS=Homo sapiens OX=9606 GN=HIC2 PE=1 SV=2 0 5.879 7 2 2 2 615 66.1 6.38 2 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465" 23119 ENSG00000169635.9 HIC2 22 0 High Q99941 Cyclic AMP-dependent transcription factor ATF-6 beta OS=Homo sapiens OX=9606 GN=ATF6B PE=1 SV=2 0 5.043 4 2 2 2 703 76.7 6.27 2 2 449394.0625 64668.4375 257497.2549 372835.1484 1 1 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane;nucleus DNA binding;protein binding "Pf00170, Pf07716" 1388 ENSG00000228628.8; ENSG00000234539.9; ENSG00000213676.10; ENSG00000168468.12 ATF6B 6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1 Viral carcinogenesis; Dopaminergic synapse; TNF signaling pathway; Hepatitis B; Amphetamine addiction; cGMP-PKG signaling pathway; Protein processing in endoplasmic reticulum; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Aldosterone synthesis and secretion; Cocaine addiction; Alcoholism; Estrogen signaling pathway; Longevity regulating pathway; PI3K-Akt signaling pathway 0 High P52948 Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4 0 5.291 1 2 2 2 1817 197.5 6.4 1 1 1 1 839933.4375 1137785.125 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytosol;membrane;nucleus catalytic activity;protein binding;RNA binding;structural molecule activity;transporter activity "Pf04096, Pf12110, Pf13634" 4928 ENSG00000110713.15 NUP98 11 RNA transport; Influenza A 0 High O14776 Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2 0 5.585 2 2 2 2 1098 123.8 8.65 2 2 235815.2031 3374576.25 1 2 metabolic process;regulation of biological process nucleus protein binding;RNA binding "Pf00397, Pf01846, Pf13949" 10915 ENSG00000113649.11 TCERG1 5 Spliceosome 0 High P04062 Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA PE=1 SV=3 0.001 3.84 3 2 2 2 536 59.7 7.61 2 2 271458.1875 3641544.625 1 2 cell communication;cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;organelle lumen;vacuole catalytic activity;protein binding Pf02055 2629 ENSG00000177628.15 GBA 1 Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis Lysosome; Sphingolipid metabolism; Other glycan degradation; Metabolic pathways 0 High Q6WKZ4 Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3 0.001 3.744 2 2 2 2 1283 137.1 5.43 2 2 478309.8125 529927.1875 1015052.156 907539.3438 1 1 2 2 regulation of biological process;transport cytoplasm;cytosol;endosome;membrane protein binding "Pf00168, Pf09457" 80223 ENSG00000156675.15 RAB11FIP1 8 Endocytosis 0 High P49257 Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2 0.001 3.992 5 2 2 2 510 57.5 6.77 2 2 750127.9063 859596 2 2 cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane metal ion binding;protein binding Pf03388 3998 ENSG00000074695.5 LMAN1 18 Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport Protein processing in endoplasmic reticulum 0 High Q6NSZ9 Zinc finger and SCAN domain-containing protein 25 OS=Homo sapiens OX=9606 GN=ZSCAN25 PE=1 SV=3 0 6.219 4 2 2 1 544 61.4 7.72 2 2 2030872.75 203908.3125 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf02023, Pf13465" 221785 ENSG00000197037.10 ZNF498; ZSCAN25 7 Generic Transcription Pathway 0 High P49790 Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2 0.001 3.913 2 2 2 2 1475 153.8 8.73 1 1 1 1 378756.125 1551969.75 1021605.438 227725.4688 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus DNA binding;metal ion binding;protein binding;structural molecule activity;transporter activity "Pf00641, Pf08604, Pf10599" 9972 ENSG00000124789.11 NUP153 6 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q9BYD1 "39S ribosomal protein L13, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" 0 4.748 11 2 2 2 178 20.7 9.16 2 2 1437930.75 4286873.875 712687.625 625298.1094 1 2 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00572 28998 ENSG00000172172.7 MRPL13 8 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High P49336 Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1 0.003 2.74 2 1 2 1 464 53.3 8.57 1 1 1 1 1124597 839752.5625 1 1 metabolic process;regulation of biological process nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1024 ENSG00000132964.11 CDK8 13 NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression 0 High Q13347 Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1 0 9.637 14 2 2 2 325 36.5 5.64 2 2 105781.8203 4104064.5 1 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol protein binding;RNA binding Pf00400 8668 ENSG00000084623.11 EIF3I 1 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High Q8WXF1 Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1 0 5.312 4 2 2 2 523 58.7 6.67 1 1 1 1 1656912.75 772666.0625 389102.3438 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 55269 ENSG00000121390.18 PSPC1 13 0 High P36969 Phospholipid hydroperoxide glutathione peroxidase OS=Homo sapiens OX=9606 GN=GPX4 PE=1 SV=3 0 8.084 13 2 2 2 197 22.2 8.37 1 1 1 1 244168.5781 3137784.625 1328120 1 2 1 cell organization and biogenesis;development;metabolic process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding Pf00255 2879 ENSG00000167468.16 GPX4 19 Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids Glutathione metabolism 0 High O95373 Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1 0.001 3.86 1 1 2 1 1038 119.4 4.82 1 2 598996.125 1 Acetyl [N-Term] defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus enzyme regulator activity;protein binding;transporter activity "Pf03810, Pf08506" 10527 ENSG00000205339.9 IPO7 11 0 High Q96EK7 Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Homo sapiens OX=9606 GN=FAM120B PE=1 SV=1 0 5.684 3 2 2 2 910 103.7 5.69 2 2 1879071.875 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus nucleus protein binding "Pf12813, Pf15548" 84498 ENSG00000275333.4; ENSG00000112584.13 FAM120B 6; CHR_HSCHR6_1_CTG5 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q9UJW7 Zinc finger protein 229 OS=Homo sapiens OX=9606 GN=ZNF229 PE=1 SV=3 0.002 2.805 6 2 2 1 825 93.6 8.53 2 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 7772 ZNF229 19 0 High Q9UKG1 DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1 0.001 3.688 4 2 2 2 709 79.6 5.41 2 2 805773.5625 447220.8125 1 1 cell proliferation;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;membrane;nucleus protein binding "Pf00169, Pf00640" 26060 ENSG00000157500.10 APPL1 3 Ligand-independent caspase activation via DCC Colorectal cancer; Pathways in cancer; Longevity regulating pathway 0 High O75127 "Pentatricopeptide repeat-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD1 PE=1 SV=2" 0 7.262 4 2 2 2 700 78.8 8.59 2 2 127852.0469 2063763.813 623875.9375 1 2 1 metabolic process mitochondrion;organelle lumen RNA binding "Pf01535, Pf13041, Pf13812" 26024 ENSG00000106246.17 PTCD1 7 0 High P56385 "ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2" 0.003 2.688 14 1 2 1 69 7.9 9.35 1 1 1 1 151877.7188 1400759.375 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf05680 521 ENSG00000169020.9 ATP5I 4 Cristae formation; Formation of ATP by chemiosmotic coupling Oxidative phosphorylation; Metabolic pathways 0 High Q9BX67 Junctional adhesion molecule C OS=Homo sapiens OX=9606 GN=JAM3 PE=1 SV=1 0 7.486 11 2 2 2 310 35 7.59 2 2 377913.0313 1068536.625 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927" 83700 ENSG00000166086.12 JAM3 11 Integrin cell surface interactions; Cell surface interactions at the vascular wall Tight junction; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection 0 High Q9NSD4 Zinc finger protein 275 OS=Homo sapiens OX=9606 GN=ZNF275 PE=1 SV=2 0 6.233 6 2 2 2 429 48.4 9.09 2 2 2925175.25 499738.5938 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 10838 ZNF275 X 0 High Q9NZE8 "39S ribosomal protein L35, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL35 PE=1 SV=3" 0.001 3.509 8 2 2 2 188 21.5 11.3 2 2 343429.4766 4961384.75 551250.8125 856438.1875 2 2 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf01632 51318 ENSG00000132313.14 MRPL35 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9UK59 Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2 0 5.51 3 2 2 2 544 61.5 5.47 2 2 4457407.375 2 metabolic process nucleus catalytic activity;metal ion binding;RNA binding "Pf00149, Pf05011" 51163 ENSG00000138231.12 DBR1 3 0 Low Q8N2I9 Serine/threonine-protein kinase 40 OS=Homo sapiens OX=9606 GN=STK40 PE=1 SV=2 0.069 0.924 2 1 2 1 435 49 7.93 1 2 2441911.25 1 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 83931 ENSG00000196182.10 STK40 1 0 High Q9Y3E5 "Peptidyl-tRNA hydrolase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PTRH2 PE=1 SV=1" 0 17.162 19 2 2 2 179 19.2 8.73 2 2 342615.875 3178628.25 61080.50781 74234.25781 1 2 1 1 cell death;regulation of biological process cytosol;membrane;mitochondrion catalytic activity;protein binding Pf01981 51651 ENSG00000141378.14 PTRH2 17 Ub-specific processing proteases 0 High Q13356 RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1 0 11.642 8 2 2 2 520 58.8 8.78 2 2 1842301.875 1 cell organization and biogenesis;cellular component movement;metabolic process cytoplasm;membrane;nucleus;organelle lumen catalytic activity;protein binding "Pf00160, Pf04641" 23759 ENSG00000100023.18 PPIL2 22 Basigin interactions Ubiquitin mediated proteolysis 0 High A0A075B6I1 Immunoglobulin lambda variable 4-60 OS=Homo sapiens OX=9606 GN=IGLV4-60 PE=3 SV=1 0.008 1.923 8 1 2 1 120 13 6.25 1 2 8054059.5 1 response to stimulus extracellular;membrane Pf07686 28785 ENSG00000211639.2 IGLV4-60 22 0 High Q96G23 Ceramide synthase 2 OS=Homo sapiens OX=9606 GN=CERS2 PE=1 SV=1 0 5.001 4 1 2 1 380 44.8 8.98 1 2 4155819 1282452.125 298938.2188 1 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane;nucleus catalytic activity;DNA binding;protein binding Pf03798 29956 ENSG00000143418.19 CERS2 1 Sphingolipid de novo biosynthesis Sphingolipid metabolism; Sphingolipid signaling pathway; Metabolic pathways 0 High O75600 "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens OX=9606 GN=GCAT PE=1 SV=1" 0.001 3.659 6 2 2 2 419 45.3 8.05 2 2 9625114 833324.4375 1953484.094 1 1 2 metabolic process membrane;mitochondrion;nucleus catalytic activity "Pf00155, Pf00266" 23464 ENSG00000100116.16 GCAT 22 Threonine catabolism "Glycine, serine and threonine metabolism" 0 High Q15527 Surfeit locus protein 2 OS=Homo sapiens OX=9606 GN=SURF2 PE=1 SV=3 0 10.063 11 2 2 2 256 29.6 9.22 2 2 137796.3906 5293904.75 147208.2031 737345.6875 1 2 1 1 membrane;nucleus Pf05477 6835 SURF2 9 0 High Q8N8D1 Programmed cell death protein 7 OS=Homo sapiens OX=9606 GN=PDCD7 PE=1 SV=1 0 10.564 7 2 2 2 485 54.7 9.95 2 2 3144742 683531 1323488.5 2 1 1 cell death;metabolic process;response to stimulus nucleus;spliceosomal complex 10081 ENSG00000090470.14 PDCD7 15 mRNA Splicing - Minor Pathway 0 High Q96JP5 E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1 0 14.066 8 2 2 2 570 63.4 7.36 2 2 4129402 156116.9531 1016966.688 2 1 1 Met-loss [N-Term] metabolic process;regulation of biological process nucleus catalytic activity;metal ion binding Pf13465 80829 ENSG00000186660.14 ZFP91 11 0 High Q9UGN5 Poly [ADP-ribose] polymerase 2 OS=Homo sapiens OX=9606 GN=PARP2 PE=1 SV=2 0 5.68 3 2 2 2 583 66.2 8.88 2 2 1436556.75 1220042.938 1 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;protein binding "Pf00644, Pf02877, Pf05406" 10038 ENSG00000129484.13 PARP2 14 Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; POLB-Dependent Long Patch Base Excision Repair; HDR through MMEJ (alt-NHEJ); Dual Incision in GG-NER Base excision repair; Apoptosis 0 High Q02224 Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2 0.002 2.887 1 2 2 2 2701 316.2 5.64 2 2 cell division;cell organization and biogenesis;cellular component movement;development;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf00225, Pf01496, Pf02463, Pf04156, Pf05557, Pf06160, Pf08317, Pf10186, Pf12128, Pf13166" 1062 ENSG00000138778.11 CENPE 4 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation 0 High Q8N3X1 Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3 0 12.295 6 2 2 2 1017 110.2 4.74 2 2 1822224 2359466.25 1 1 protein binding Pf00397 23360 ENSG00000109920.12 FNBP4 11 0 High Q9BR77 Coiled-coil domain-containing protein 77 OS=Homo sapiens OX=9606 GN=CCDC77 PE=1 SV=1 0 10.141 8 2 2 2 488 57.5 8.72 2 2 594590.8125 1 membrane 84318 ENSG00000120647.9 CCDC77 12 0 High Q9NZ45 CDGSH iron-sulfur domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CISD1 PE=1 SV=1 0.002 3.049 12 1 2 1 108 12.2 9.09 1 1 1 1 491052.2188 423355.0938 543831.8125 1 1 1 regulation of biological process membrane;mitochondrion metal ion binding;protein binding Pf09360 55847 ENSG00000122873.11 CISD1 10 0 High Q7Z4R8 UPF0669 protein C6orf120 OS=Homo sapiens OX=9606 GN=C6ORF120 PE=1 SV=1 0 5.251 14 1 2 1 191 20.8 4.84 1 1 1 1 737171 891476.1875 1 1 cell death;transport extracellular;organelle lumen 387263 ENSG00000185127.6 C6orf120 6 Neutrophil degranulation 0 High Q9Y2U8 Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2 0.004 2.306 1 1 2 1 911 99.9 7.55 1 1 1 1 691844.6875 466004.0625 1 1 cell organization and biogenesis;regulation of biological process membrane;nucleus DNA binding;protein binding "Pf03020, Pf09402" 23592 ENSG00000174106.2 LEMD3 12 Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High Q06033 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo sapiens OX=9606 GN=ITIH3 PE=1 SV=2 0.001 3.894 2 2 2 1 890 99.8 5.74 2 2 metabolic process;regulation of biological process;transport extracellular;organelle lumen enzyme regulator activity "Pf00092, Pf06668, Pf08487, Pf11443, Pf13519, Pf13768" 3699 ENSG00000162267.12 ITIH3 3 Platelet degranulation 0 High Q99460 26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2 0 4.804 3 2 2 2 953 105.8 5.39 2 2 446479.0313 210119.3281 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;enzyme regulator activity;protein binding "Pf01851, Pf13513, Pf13646" 5707 ENSG00000173692.12 PSMD1 2 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 High Q16795 "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA9 PE=1 SV=2" 0 5.458 6 2 2 2 377 42.5 9.8 2 2 1594863.375 268420.9375 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding "Pf01073, Pf01370, Pf05368" 4704 ENSG00000139180.10 NDUFA9 12 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 Medium Q9ULU8 Calcium-dependent secretion activator 1 OS=Homo sapiens OX=9606 GN=CADPS PE=1 SV=3 0.018 1.629 1 1 2 1 1353 152.7 5.71 1 2 11415579 7020290 1 1 cell organization and biogenesis;transport cytosol;membrane metal ion binding;protein binding "Pf00169, Pf06292" 8618 ENSG00000163618.17 CADPS 3 0 Medium Q8N0Y2 Zinc finger protein 444 OS=Homo sapiens OX=9606 GN=ZNF444 PE=1 SV=1 0.011 1.851 2 1 2 1 327 35.2 8.56 1 2 219391.3594 4035511 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf02023, Pf13465" 55311 ENSG00000167685.14 ZNF444 19 0 High P53803 "DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1" 0 7.541 43 2 2 2 58 7 9.06 2 2 3332455.75 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;metal ion binding Pf03604 5440 ENSG00000147669.10 POLR2K 8 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens OX=9606 GN=MKRN2 PE=1 SV=2 0 4.597 6 2 2 2 416 46.9 7.61 2 2 3643194.625 2 metabolic process catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00642, Pf13639" 23609 ENSG00000075975.15 MKRN2 3 0 High Q8N999 Uncharacterized protein C12orf29 OS=Homo sapiens OX=9606 GN=C12ORF29 PE=1 SV=2 0 6.274 8 2 2 2 325 37.5 7.06 2 2 3619871.875 2 cell differentiation 91298 ENSG00000133641.17 C12orf29 12 0 High Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens OX=9606 GN=ITIH4 PE=1 SV=4 0.002 2.966 1 1 2 1 930 103.3 6.98 1 2 2592218.5 1149869.25 406381.25 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;organelle lumen enzyme regulator activity;protein binding "Pf00092, Pf06668, Pf08487, Pf10138, Pf13444, Pf13519, Pf13768" 3700 ENSG00000055955.15 ITIH4 3 Platelet degranulation 0 High Q12800 Alpha-globin transcription factor CP2 OS=Homo sapiens OX=9606 GN=TFCP2 PE=1 SV=2 0 5.357 7 2 2 2 502 57.2 5.8 2 2 566137.625 190410.1875 8003098.094 1 1 2 metabolic process;regulation of biological process cytosol;nucleus DNA binding;protein binding Pf04516 7024 ENSG00000135457.9 TFCP2 12 0 High Q9H4F1 "Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase OS=Homo sapiens OX=9606 GN=ST6GALNAC4 PE=2 SV=2" 0.003 2.686 4 1 2 1 302 34.2 8.57 1 2 859477.3125 1635365.75 1 1 metabolic process Golgi;membrane catalytic activity Pf00777 27090 ENSG00000136840.18 ST6GALNAC4 9 Termination of O-glycan biosynthesis; Sialic acid metabolism Glycosphingolipid biosynthesis - ganglio series; Metabolic pathways 0 High P33176 Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1 0.001 4.035 2 2 2 2 963 109.6 6.51 2 2 1057868.438 2 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf01576, Pf02463, Pf03999, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06160, Pf07111, Pf07888, Pf10174, Pf12128, Pf13514, Pf13851, Pf14915" 3799 ENSG00000170759.10 KIF5B 10 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1; Insulin processing; MHC class II antigen presentation Dopaminergic synapse; Endocytosis 0 High O75521 "Enoyl-CoA delta isomerase 2, mitochondrial OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" 0.001 4.147 5 2 2 2 394 43.6 9 2 2 7863669 641568.875 939387.5 1 1 2 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding "Pf00378, Pf00887" 10455 ENSG00000198721.12 ECI2 6 Peroxisome; Fatty acid degradation 0 High Q92820 Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2 0 4.821 7 2 2 2 318 35.9 7.11 2 2 1583354.375 101727.1172 1787736.875 1 1 2 metabolic process;response to stimulus;transport cytosol;extracellular;nucleus;organelle lumen;vacuole catalytic activity "Pf00117, Pf07722" 8836 ENSG00000137563.11 GGH 8 Neutrophil degranulation Folate biosynthesis; Antifolate resistance 0 High Q14494 Endoplasmic reticulum membrane sensor NFE2L1 OS=Homo sapiens OX=9606 GN=NFE2L1 PE=1 SV=1 0 7.888 3 2 2 2 772 84.7 4.64 2 2 1437080.125 1 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf07716" 4779 ENSG00000082641.15 NFE2L1 17 0 High O00303 Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1 0 6.714 7 2 2 2 357 37.5 5.45 2 2 3909282.75 2 metabolic process cytoplasm;cytosol;membrane catalytic activity;protein binding;RNA binding "Pf01398, Pf13012" 8665 ENSG00000280606.3; ENSG00000175390.13 EIF3F 11; CHR_HSCHR11_1_CTG1_2 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High Q9P265 Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3 0.001 4.232 1 2 2 2 1576 171.4 8.09 2 2 3196029.125 2 metabolic process cytoplasm;membrane;nucleus catalytic activity "Pf00501, Pf06464" 57609 ENSG00000066084.12 DIP2B 12 0 High P0DN79 Cystathionine beta-synthase-like protein OS=Homo sapiens OX=9606 GN=CBSL PE=1 SV=1 0 4.614 3 2 2 2 551 60.5 6.65 2 2 790633.5938 5310.146484 2 1 cell communication;metabolic process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf00291, Pf00571" 875; 102724560 ENSG00000160200.17; ENSG00000274276.4 CBS; LOC102724560; CBSL 21 "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Metabolic pathways; Cysteine and methionine metabolism" 0 High Q15758 Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2 0.002 2.914 2 1 2 1 541 56.6 5.48 1 2 6700293 1255368.5 1620798.625 1 1 1 transport membrane protein binding;receptor activity;transporter activity Pf00375 6510 ENSG00000105281.12 SLC1A5 19 Amino acid transport across the plasma membrane Central carbon metabolism in cancer; Protein digestion and absorption 0 Medium Q86VP6 Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2 0.027 1.48 1 1 2 1 1230 136.3 5.78 1 1 1 1 478575.1563 515253.8125 1 1 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen protein binding "Pf08623, Pf12755, Pf13513" 55832 ENSG00000111530.12 CAND1 12 Neutrophil degranulation; Iron uptake and transport; Neddylation 0 High Q71F23 Centromere protein U OS=Homo sapiens OX=9606 GN=CENPU PE=1 SV=1 0 15.598 12 2 2 2 418 47.5 9.13 2 2 2567161.75 1 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;nucleus protein binding Pf13097 79682 ENSG00000151725.11 MLF1IP; CENPU 4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Deposition of new CENPA-containing nucleosomes at the centromere 0 High P39748 Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1 0 4.941 4 2 2 2 380 42.6 8.62 1 1 1 1 3531722.625 552532.25 2 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00752, Pf00867, Pf01367" 2237 ENSG00000168496.3 FEN1 11 POLB-Dependent Long Patch Base Excision Repair; Early Phase of HIV Life Cycle; Removal of the Flap Intermediate; HDR through MMEJ (alt-NHEJ); PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate from the C-strand DNA replication; Non-homologous end-joining; Base excision repair 0 High Q14165 Malectin OS=Homo sapiens OX=9606 GN=MLEC PE=1 SV=1 0 5.208 9 2 2 2 292 32.2 5.41 2 2 1448799.625 982211.375 1 1 metabolic process;transport endoplasmic reticulum;membrane protein binding Pf11721 9761 ENSG00000110917.7 MLEC 12 Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0 High Q05397 Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2 0 4.95 2 2 2 2 1052 119.2 6.62 1 1 1 1 853865.1875 1650860.75 1069899.75 229680.2188 1 1 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00373, Pf03623, Pf07714, Pf14531" 5747 ENSG00000169398.19 PTK2 8 DCC mediated attractive signaling; Netrin mediated repulsion signals; MET activates PTK2 signaling; Signal regulatory protein family interactions; Apoptotic cleavage of cellular proteins; VEGFA-VEGFR2 Pathway; GRB2:SOS provides linkage to MAPK signaling for Integrins ; NCAM signaling for neurite out-growth; p130Cas linkage to MAPK signaling for integrins; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RAF/MAP kinase cascade; Interleukin-20 family signaling Amoebiasis; VEGF signaling pathway; ErbB signaling pathway; Pathways in cancer; Focal adhesion; Proteoglycans in cancer; Transcriptional misregulation in cancer; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Small cell lung cancer; Endocrine resistance; Chemokine signaling pathway; Axon guidance; PI3K-Akt signaling pathway 0 Medium Q08AF3 Schlafen family member 5 OS=Homo sapiens OX=9606 GN=SLFN5 PE=1 SV=1 0.025 1.538 1 1 2 1 891 101 8.22 1 2 2747814.5 5123472.5 1 1 cell differentiation nucleus nucleotide binding "Pf04326, Pf09848, Pf13401, Pf13538" 162394 ENSG00000166750.9 SLFN5 17 0 High Q96JQ2 Calmin OS=Homo sapiens OX=9606 GN=CLMN PE=1 SV=1 0.001 4.157 3 2 2 2 1002 111.6 4.94 2 2 667623.375 640623.9375 299828.1875 1 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;membrane protein binding Pf00307 79789 ENSG00000165959.11 CLMN 14 0 High Q86UP2 Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1 0.001 3.737 3 2 2 2 1357 156.2 5.64 1 1 1 1 cellular component movement;metabolic process endoplasmic reticulum;membrane;organelle lumen protein binding;RNA binding 3895 ENSG00000126777.17 KTN1 14 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); RHO GTPases activate KTN1 0 High Q16555 Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1 0 4.508 4 2 2 2 572 62.3 6.38 2 2 259501.0781 1 cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;protein binding "Pf01979, Pf07969, Pf13147, Pf13594" 1808 ENSG00000092964.17 DPYSL2 8 Recycling pathway of L1; CRMPs in Sema3A signaling Axon guidance 0 High Q2QGD7 Zinc finger protein ZXDC OS=Homo sapiens OX=9606 GN=ZXDC PE=1 SV=2 0 8.374 5 2 2 2 858 89.9 8.13 2 2 785922.625 1 Acetyl [N-Term] metabolic process;regulation of biological process nucleus metal ion binding;protein binding 79364 ENSG00000070476.14 ZXDC 3 0 High Q9NXS2 Glutaminyl-peptide cyclotransferase-like protein OS=Homo sapiens OX=9606 GN=QPCTL PE=1 SV=2 0.001 3.533 3 1 2 1 382 42.9 9.82 1 2 13018080 352283.875 878603.125 1 1 1 metabolic process Golgi;membrane catalytic activity;metal ion binding Pf04389 54814 ENSG00000011478.11 QPCTL 19 0 High Q96GI7 Protein FAM89A OS=Homo sapiens OX=9606 GN=FAM89A PE=1 SV=1 0 5.074 15 2 2 2 184 19.6 5.92 2 2 1466146.063 1283097.875 2 2 375061 ENSG00000182118.7 FAM89A 1 0 High Q96JJ7 Protein disulfide-isomerase TMX3 OS=Homo sapiens OX=9606 GN=TMX3 PE=1 SV=2 0.002 2.804 4 1 2 1 454 51.8 4.91 1 2 1634801.75 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13899" 54495 ENSG00000166479.9 TMX3 18 Platelet degranulation 0 High Q9UBE0 SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1 0.001 3.304 5 2 2 2 346 38.4 5.3 2 2 287379.75 1140075.719 1 2 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;enzyme regulator activity;protein binding Pf00899 10055 ENSG00000142230.11 SAE1 19 "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" Ubiquitin mediated proteolysis 0 High Q8NEF9 Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1 0 5.467 4 2 2 2 429 48.6 9.58 2 2 3000413.563 2 metabolic process;regulation of biological process cytoplasm;nucleus RNA binding Pf09073 153443 ENSG00000151304.5 SRFBP1 5 0 High Q9HC07 Transmembrane protein 165 OS=Homo sapiens OX=9606 GN=TMEM165 PE=1 SV=1 0.001 3.54 8 1 2 1 324 34.9 7.02 1 2 cellular homeostasis;metabolic process;transport endosome;Golgi;membrane;vacuole Pf01169 55858 ENSG00000134851.12 TMEM165 4 0 High Q14674 Separin OS=Homo sapiens OX=9606 GN=ESPL1 PE=1 SV=3 0 12.076 2 2 2 2 2120 233 7.55 2 2 929350.375 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding Pf03568 9700 ENSG00000135476.11 ESPL1 12 Separation of Sister Chromatids Oocyte meiosis; Cell cycle 0 High Q14703 Membrane-bound transcription factor site-1 protease OS=Homo sapiens OX=9606 GN=MBTPS1 PE=1 SV=1 0 8.058 1 2 2 2 1052 117.7 8.75 2 2 463414.7813 2389206.5 227877.0313 1513347.906 1 1 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane;organelle lumen catalytic activity "Pf00082, Pf14258" 8720 ENSG00000140943.16 MBTPS1 16 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Assembly of active LPL and LIPC lipase complexes; Regulation of cholesterol biosynthesis by SREBP (SREBF); CREB3 factors activate genes; ATF6 (ATF6-alpha) activates chaperones Protein processing in endoplasmic reticulum 0 High P46821 Microtubule-associated protein 1B OS=Homo sapiens OX=9606 GN=MAP1B PE=1 SV=2 0 5.809 1 2 2 1 2468 270.5 4.81 1 1 1 1 302195.2188 1 cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity 4131 ENSG00000131711.14 MAP1B 5 0 Medium P59665 Neutrophil defensin 1 OS=Homo sapiens OX=9606 GN=DEFA1 PE=1 SV=1 0.016 1.663 10 1 2 1 94 10.2 6.99 1 2 1620789.25 600231.6875 1 1 cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport extracellular;organelle lumen "Pf00323, Pf00879" 1667; 728358 ENSG00000206047.2; ENSG00000240247.7 DEFA1; DEFA1B 8 Alpha-defensins; Neutrophil degranulation 0 High Q5H9F3 BCL-6 corepressor-like protein 1 OS=Homo sapiens OX=9606 GN=BCORL1 PE=1 SV=1 0.002 2.788 1 2 2 2 1711 182.4 7.24 2 2 6226973 509280.4688 1015079.438 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 63035 BCORL1 X 0 High P25440 Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2 0 4.816 4 2 2 2 801 88 9.09 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding Pf00439 6046 ENSG00000204256.12; ENSG00000235307.9; ENSG00000234507.9; ENSG00000215077.10 BRD2 6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1 RUNX3 regulates p14-ARF 0 High Q8TF76 Serine/threonine-protein kinase haspin OS=Homo sapiens OX=9606 GN=HASPIN PE=1 SV=3 0 5.141 3 2 2 2 798 88.4 9.16 2 2 2379524.375 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12330" 83903 ENSG00000177602.5 GSG2; HASPIN 17 0 Low Q9C000 "NACHT, LRR and PYD domains-containing protein 1 OS=Homo sapiens OX=9606 GN=NLRP1 PE=1 SV=1" 0.073 0.887 1 1 2 1 1473 165.8 6.84 1 2 105797.1484 36925.60938 1 1 cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;transporter activity "Pf00619, Pf02758, Pf05729, Pf06414, Pf13191, Pf13207, Pf13516, Pf13553, Pf13604" 22861 ENSG00000091592.15 NLRP1 17 The NLRP1 inflammasome NOD-like receptor signaling pathway 0 High P23193 Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2 0 7.391 9 2 2 2 301 33.9 8.38 2 2 421986.0313 2940917.5 1 1 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding;protein binding "Pf01096, Pf07500, Pf08711" 6917 ENSG00000187735.13 TCEA1 8 HIV elongation arrest and recovery; Gap-filling DNA repair synthesis and ligation in TC-NER; TP53 Regulates Transcription of DNA Repair Genes; Dual incision in TC-NER; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat 0 High O75528 Transcriptional adapter 3 OS=Homo sapiens OX=9606 GN=TADA3 PE=1 SV=1 0 4.955 6 2 2 2 432 48.9 6.27 1 1 1 1 40445713.25 692864.1875 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;protein binding Pf10198 10474 ENSG00000171148.13 TADA3 3 HATs acetylate histones; Ub-specific processing proteases 0 High Q92947 "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" 0 5.716 5 2 2 2 438 48.1 8.06 1 1 1 1 512147.1875 1 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 2639 ENSG00000105607.12 GCDH 19 Lysine catabolism Fatty acid degradation; Lysine degradation; Metabolic pathways; Tryptophan metabolism 0 High Q13217 DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1 0.001 4.057 4 2 2 2 504 57.5 6.15 2 2 5935765.25 193031.2813 1087759.063 2 1 2 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;organelle lumen enzyme regulator activity;protein binding "Pf00226, Pf00515, Pf12569, Pf13371, Pf13414, Pf13432, Pf14559" 5611 ENSG00000102580.14 DNAJC3 13 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Viral mRNA Translation; Neutrophil degranulation; XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum; Influenza A 0 High O60343 TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2 0.001 3.202 2 2 2 2 1298 146.5 7.01 2 2 430401.8438 649929.9063 1 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane enzyme regulator activity;protein binding "Pf00566, Pf00640, Pf11830" 9882 ENSG00000136111.12 TBC1D4 13 Translocation of GLUT4 to the plasma membrane Thyroid hormone signaling pathway; Insulin resistance 0 High Q8WUM0 Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2 0.001 4.087 2 2 2 2 1156 128.9 5.1 1 1 1 1 2688553.406 368444.1563 775790.1875 2 1 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytosol;membrane;nucleus protein binding;structural molecule activity;transporter activity "Pf03177, Pf08801" 55746 ENSG00000069248.11 NUP133 1 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P19823 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2 0 5.353 2 2 2 2 946 106.4 6.86 1 1 1 1 405668.5938 2005289 1167656.125 1 1 1 metabolic process;regulation of biological process extracellular;organelle lumen enzyme regulator activity "Pf00092, Pf06668, Pf08487, Pf13519, Pf13768" 3698 ENSG00000151655.18 ITIH2 10 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0 Medium Q53FA7 Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2 0.048 1.127 5 1 2 1 332 35.5 7.17 1 2 27177996 125970.1484 1 1 metabolic process;regulation of biological process cytosol catalytic activity;nucleotide binding;protein binding "Pf00107, Pf01455, Pf08240, Pf13602" 9540 ENSG00000115129.13 TP53I3 2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain p53 signaling pathway 0 High Q86Y07 Serine/threonine-protein kinase VRK2 OS=Homo sapiens OX=9606 GN=VRK2 PE=1 SV=3 0 10.102 5 2 2 2 508 58.1 8.84 2 2 2227289 7623.056152 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 7444 ENSG00000028116.16 VRK2 2 0 High P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1 0.004 2.326 3 1 2 1 381 43 5.35 1 2 239331.1094 1 cell organization and biogenesis;cell proliferation;coagulation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00027, Pf02197" 5573 ENSG00000108946.14 PRKAR1A 17 Signaling by GPCR; PKA activation in glucagon signalling; PKA activation; DARPP-32 events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production Insulin signaling pathway 0 High Q8N726 Tumor suppressor ARF OS=Homo sapiens OX=9606 GN=CDKN2A PE=1 SV=2 0 11.318 14 1 2 1 132 13.9 12.41 1 2 8017589.5 295433.2188 1 1 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding Pf07392 1029 ENSG00000147889.17 CDKN2A 9 Regulation of TP53 Degradation; Stabilization of p53; Regulation of RUNX3 expression and activity; SUMOylation of transcription factors; Oncogene Induced Senescence; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence 0 High P24941 Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2 0.001 4.211 6 2 2 1 298 33.9 8.68 1 1 1 1 cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;cytosol;endosome;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 1017 ENSG00000123374.10 CDK2 12 p53-Dependent G1 DNA Damage Response; G0 and Early G1; Regulation of DNA replication; Activation of the pre-replicative complex; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; SCF(Skp2)-mediated degradation of p27/p21; Factors involved in megakaryocyte development and platelet production; G2 Phase; Meiotic recombination; Regulation of APC/C activators between G1/S and early anaphase; PTK6 Regulates Cell Cycle; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Degradation; CDK-mediated phosphorylation and removal of Cdc6; Orc1 removal from chromatin; Cyclin A/B1/B2 associated events during G2/M transition; M/G1 Transition; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Removal of licensing factors from origins Viral carcinogenesis; Hepatitis B; FoxO signaling pathway; Epstein-Barr virus infection; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; p53 signaling pathway; Oocyte meiosis; Measles; Small cell lung cancer; Herpes simplex infection; Cell cycle; PI3K-Akt signaling pathway 0 High P50995 Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1 0 4.934 5 2 2 2 505 54.4 7.65 2 2 275445.1563 3447157.5 581580.625 340798.0938 1 2 1 1 cell division;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;vacuole metal ion binding;protein binding;RNA binding Pf00191 311 ENSG00000122359.17 ANXA11 10 0 High P49750 YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4 0 9.043 2 2 2 2 2146 241.5 6.55 2 2 562372 1 0 High O75251 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3" 0 7.86 17 2 2 2 213 23.5 9.99 1 1 1 1 902206.4531 962042.9375 2 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding Pf01058 374291 ENSG00000115286.19 NDUFS7 19 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q13503 Mediator of RNA polymerase II transcription subunit 21 OS=Homo sapiens OX=9606 GN=MED21 PE=1 SV=1 0 8.719 26 2 2 2 144 15.6 4.45 1 1 1 1 844804.9375 333249.4688 979631.0625 2286439.75 1 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf11221 9412 ENSG00000152944.8 MED21 12 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q13561 Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4 0.002 2.781 4 2 2 2 401 44.2 5.21 1 1 1 1 571401.875 1181850.469 754285.125 221089.7969 1 2 1 1 cell organization and biogenesis;cell proliferation;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;protein binding Pf04912 10540 ENSG00000175203.15 DCTN2 12 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) Huntington's disease; Vasopressin-regulated water reabsorption 0 High Q9P2N5 RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2 0 16.786 2 1 2 1 1060 118.6 9.19 1 2 2207041.313 1 metabolic process cytoplasm;nucleus metal ion binding;RNA binding "Pf00076, Pf00642, Pf03962, Pf13893, Pf14259" 54439 ENSG00000091009.7 RBM27 5 0 High Q56NI9 N-acetyltransferase ESCO2 OS=Homo sapiens OX=9606 GN=ESCO2 PE=1 SV=1 0 7.854 4 2 2 2 601 68.3 9.39 2 2 3264298.25 392247.7813 2 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus chromosome;Golgi;nucleus catalytic activity;metal ion binding "Pf13878, Pf13880" 157570 ENSG00000171320.14 ESCO2 8 Establishment of Sister Chromatid Cohesion 0 High P52756 RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2 0 12.129 5 2 2 2 815 92.1 6.28 2 2 2006291.25 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process nucleus;spliceosomal complex DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf01585, Pf12656, Pf14259" 10181 ENSG00000003756.16 RBM5 3 mRNA Splicing - Major Pathway 0 High O14818 Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1 0 5.223 9 2 2 2 248 27.9 8.46 1 1 1 1 48031444 1891885.563 1436053.063 1 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;nucleotide binding;protein binding "Pf00227, Pf10584" 5688 ENSG00000101182.14 PSMA7 20 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q9P2K8 eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3 0 6.133 2 2 2 2 1649 186.8 6.28 2 2 662407.2813 1431496.625 897883.6875 2 1 1 cell communication;cell growth;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf00587, Pf05773, Pf07714, Pf12745" 440275 ENSG00000128829.11 EIF2AK4 15 Epstein-Barr virus infection; Protein processing in endoplasmic reticulum; Measles; Herpes simplex infection; Hepatitis C; Influenza A 0 Medium Q8IYS0 Protein Aster-C OS=Homo sapiens OX=9606 GN=GRAMD1C PE=1 SV=2 0.03 1.424 1 1 2 1 662 76 7.24 1 2 6370399.5 1 membrane protein binding Pf02893 54762 ENSG00000178075.19 GRAMD1C 3 0 High Q9UKK6 NTF2-related export protein 1 OS=Homo sapiens OX=9606 GN=NXT1 PE=1 SV=1 0 6.803 17 2 2 2 140 15.8 5.03 2 2 3657834.25 1 transport cytoplasm;cytosol;nucleus protein binding Pf02136 29107 ENSG00000132661.3 NXT1 20 Transport of Mature mRNA derived from an Intron-Containing Transcript Ribosome biogenesis in eukaryotes; mRNA surveillance pathway; RNA transport; Influenza A 0 High P20618 Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2 0 5.285 9 2 2 2 241 26.5 8.13 2 2 469745.5938 756891.1094 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome catalytic activity;protein binding Pf00227 5689 ENSG00000008018.8 PSMB1 6 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High O43422 52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens OX=9606 GN=THAP12 PE=1 SV=2 0 7.821 3 2 2 2 761 87.6 5.86 2 2 2529174.75 1 regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;metal ion binding;protein binding "Pf05485, Pf05699" 5612 ENSG00000137492.7 PRKRIR; THAP12 11 0 High Q6P5Z2 Serine/threonine-protein kinase N3 OS=Homo sapiens OX=9606 GN=PKN3 PE=1 SV=1 0 8.377 5 2 2 2 889 99.4 8.46 2 2 cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;Golgi;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf02185, Pf07714, Pf14531" 29941 ENSG00000160447.6 PKN3 9 RHO GTPases activate PKNs Salmonella infection; PI3K-Akt signaling pathway 0 High Q9NX95 Syntabulin OS=Homo sapiens OX=9606 GN=SYBU PE=1 SV=2 0 5.48 10 2 2 2 663 72.3 6.25 1 1 1 1 440419.8125 1 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi;membrane protein binding Pf15290 55638 ENSG00000147642.16 SYBU 8 0 High Q13114 TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2 0.003 2.751 4 2 2 2 568 64.4 7.91 2 2 576798.9688 468843.3438 169657.5469 2 1 1 cell death;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;mitochondrion catalytic activity;metal ion binding;protein binding;signal transducer activity "Pf00097, Pf00917, Pf02176, Pf05557, Pf10174" 7187 ENSG00000131323.14 TRAF3 14 TRAF3 deficiency - HSE; TICAM1-dependent activation of IRF3/IRF7; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Negative regulators of DDX58/IFIH1 signaling; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; Activated TLR4 signalling Viral carcinogenesis; TNF signaling pathway; NOD-like receptor signaling pathway; Epstein-Barr virus infection; Pathways in cancer; NF-kappa B signaling pathway; Small cell lung cancer; Toll-like receptor signaling pathway; Herpes simplex infection; Hepatitis C; RIG-I-like receptor signaling pathway 0 High P43246 DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1 0.001 3.253 2 2 2 2 934 104.7 5.77 2 2 302303.1875 476827.4844 1 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" 4436 ENSG00000095002.13 MSH2 2 Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); TP53 Regulates Transcription of DNA Repair Genes; Defective Mismatch Repair Associated With MSH6 Colorectal cancer; Pathways in cancer; Mismatch repair; Platinum drug resistance 0 High Q8TF39 Zinc finger protein 483 OS=Homo sapiens OX=9606 GN=ZNF483 PE=1 SV=3 0 6.902 3 2 2 2 744 85 8.57 2 2 3642294.875 13815.55664 2 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf02023, Pf13465" 158399 ENSG00000173258.12 ZNF483 9 Generic Transcription Pathway 0 High P84022 Mothers against decapentaplegic homolog 3 OS=Homo sapiens OX=9606 GN=SMAD3 PE=1 SV=1 0 6.866 6 2 2 2 425 48.1 7.15 2 2 1512011.375 716477.375 16116.79688 1 1 1 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus DNA binding;metal ion binding;protein binding;RNA binding;signal transducer activity "Pf03165, Pf03166" 4088 ENSG00000166949.15 SMAD3 15 Signaling by NODAL; SMAD2/3 Phosphorylation Motif Mutants in Cancer; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling; SMAD4 MH2 Domain Mutants in Cancer; Signaling by Activin; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription Chagas disease (American trypanosomiasis); Endocytosis; TGF-beta signaling pathway; Inflammatory bowel disease (IBD); Hepatitis B; Pancreatic cancer; FoxO signaling pathway; Chronic myeloid leukemia; Hippo signaling pathway; Colorectal cancer; Pathways in cancer; AGE-RAGE signaling pathway in diabetic complications; HTLV-I infection; Wnt signaling pathway; Adherens junction; Cell cycle; Signaling pathways regulating pluripotency of stem cells 0 High P05166 "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3" 0 9.501 5 2 2 2 539 58.2 7.64 1 1 1 1 3571157.563 1692657.75 1581360.938 2 2 2 metabolic process cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding Pf01039 5096 ENSG00000114054.13 PCCB 3 Defective HLCS causes multiple carboxylase deficiency; Biotin transport and metabolism; Propionyl-CoA catabolism "Propanoate metabolism; Carbon metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Valine, leucine and isoleucine degradation" 0 High Q9NP50 SIN3-HDAC complex-associated factor OS=Homo sapiens OX=9606 GN=SINHCAF PE=1 SV=1 0 8.961 12 2 2 2 221 24.8 9.41 2 2 4277833.625 2 regulation of biological process nucleus protein binding Pf15396 58516 ENSG00000139146.13; ENSG00000276371.2 FAM60A; SINHCAF 12; CHR_HSCHR12_4_CTG2 0 High P08574 "Cytochrome c1, heme protein, mitochondrial OS=Homo sapiens OX=9606 GN=CYC1 PE=1 SV=3" 0 4.673 4 1 2 1 325 35.4 9 1 2 1676874.25 794525.9375 3233879.25 1 1 1 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus metal ion binding Pf02167 1537 ENSG00000179091.4 CYC1 8 Respiratory electron transport; Mitochondrial protein import; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 High Q9H840 Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1 0.001 3.416 31 2 2 2 131 14.5 7.4 2 2 429878.375 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus protein binding Pf11095 79760 ENSG00000142252.10 GEMIN7 19 snRNP Assembly RNA transport 0 High P07942 Laminin subunit beta-1 OS=Homo sapiens OX=9606 GN=LAMB1 PE=1 SV=2 0.004 2.347 0 1 2 1 1786 197.9 4.94 1 2 835900.75 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen catalytic activity;motor activity;nucleotide binding;protein binding;signal transducer activity;structural molecule activity "Pf00015, Pf00053, Pf00055, Pf01576, Pf02841, Pf03938, Pf04156, Pf05103, Pf05335, Pf05667, Pf05698, Pf05701, Pf06428, Pf07111, Pf07767, Pf08317, Pf08647, Pf09731, Pf10174, Pf13476, Pf13514, Pf13851, Pf15346, Pf15619" 3912 ENSG00000091136.13 LAMB1 7 ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions Amoebiasis; Pathways in cancer; Toxoplasmosis; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q32P28 Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2 0.001 3.866 2 2 2 2 736 83.3 5.14 2 2 170982.0469 760297.5938 1 2 metabolic process;regulation of biological process endoplasmic reticulum;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding Pf13640 64175 ENSG00000117385.15 LEPRE1; P3H1 1 Collagen biosynthesis and modifying enzymes 0 High P78348 Acid-sensing ion channel 1 OS=Homo sapiens OX=9606 GN=ASIC1 PE=1 SV=3 0 4.979 4 2 2 2 528 59.9 5.73 2 2 931783.8438 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cell surface;Golgi;membrane protein binding;transporter activity Pf00858 41 ENSG00000110881.11 ASIC1 12 Stimuli-sensing channels Inflammatory mediator regulation of TRP channels 0 High Q53H96 Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3 0 6.106 10 2 2 2 274 28.6 7.72 1 1 1 1 516106.457 1931225.125 514234.0938 510042.3438 2 1 1 1 metabolic process cytoplasm;cytosol catalytic activity;protein binding "Pf03807, Pf14748" 65263 ENSG00000276657.2; ENSG00000104524.13 PYCRL; PYCR3 8; CHR_HSCHR8_3_CTG7 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 High Q01082 "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" 0.003 2.653 1 2 2 2 2364 274.4 5.57 2 2 467129.0625 334586.5 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding;structural molecule activity "Pf00169, Pf00307, Pf00435, Pf11971, Pf12128, Pf15410" 6711 ENSG00000115306.15 SPTBN1 2 Nephrin family interactions; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interleukin-20 family signaling 0 High Q9H0V9 VIP36-like protein OS=Homo sapiens OX=9606 GN=LMAN2L PE=1 SV=1 0.002 3.002 4 2 2 2 348 39.7 8.38 2 2 503767.5938 400055.3438 791941.8438 1 1 2 metabolic process;transport endoplasmic reticulum;Golgi;membrane metal ion binding Pf03388 81562 ENSG00000114988.11 LMAN2L 2 Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport 0 High P12270 Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3 0.001 3.936 0 1 2 1 2363 267.1 5.02 1 1 1 1 137065.3125 242856.8906 42527.58203 1 1 1 Met-loss+Acetyl [N-Term] cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity;transporter activity "Pf00038, Pf01496, Pf01576, Pf02463, Pf03961, Pf04111, Pf05911, Pf07888, Pf07926, Pf09726, Pf12128, Pf13166, Pf13514" 7175 ENSG00000047410.13 TPR 1 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins Pathways in cancer; RNA transport; Thyroid cancer 0 High Q8IUC8 Polypeptide N-acetylgalactosaminyltransferase 13 OS=Homo sapiens OX=9606 GN=GALNT13 PE=2 SV=2 0.002 3.067 3 2 2 2 556 64 6.83 2 2 888365.375 1559111.938 1 2 metabolic process Golgi;membrane catalytic activity;metal ion binding "Pf00535, Pf00652, Pf02709, Pf13632" 114805 ENSG00000144278.14 GALNT13 2 O-linked glycosylation of mucins Mucin type O-glycan biosynthesis; Metabolic pathways 0 High Q96MN5 Transcription elongation factor A N-terminal and central domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TCEANC2 PE=1 SV=1 0 4.941 11 2 2 2 208 24.1 10.05 2 2 2009429.75 1 metabolic process nucleus DNA binding;protein binding "Pf07500, Pf08711" 127428 ENSG00000116205.12 TCEANC2 1 0 High O43615 Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2 0 6.372 6 2 2 2 452 51.3 8.32 1 1 1 1 1746080.188 2014981.813 2 2 transport membrane;mitochondrion;organelle lumen nucleotide binding;protein binding "Pf04280, Pf07091" 10469 ENSG00000104980.7 TIMM44 19 Mitochondrial protein import; Metabolism of proteins 0 High Q9H0M5 Zinc finger protein 700 OS=Homo sapiens OX=9606 GN=ZNF700 PE=2 SV=1 0 7.525 4 2 2 1 742 86.2 8.9 2 2 1036608.938 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 90592 ENSG00000196757.7 ZNF700 19 Generic Transcription Pathway 0 High Q7L2K0 Tubulin epsilon and delta complex protein 2 OS=Homo sapiens OX=9606 GN=TEDC2 PE=1 SV=1 0 8.624 12 2 2 2 433 46.4 9.38 2 2 800854.7813 2 protein binding 80178 ENSG00000162062.14 C16orf59; TEDC2 16 0 High Q9BPZ3 Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1 0.004 2.398 24 1 2 1 127 15 4.12 1 2 2863604 802372.25 1 1 regulation of biological process;response to stimulus cytoplasm protein binding;RNA binding;translation regulator activity Pf07145 51247 ENSG00000120727.12 PAIP2 5 0 High Q9NXV6 CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3 0 7.992 4 2 2 2 580 61.1 9.01 2 2 1129217.875 1 regulation of biological process;response to stimulus nucleus protein binding;RNA binding Pf11952 55602 ENSG00000168564.5 CDKN2AIP 4 0 High Q9NX74 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens OX=9606 GN=DUS2 PE=1 SV=1 0 5.779 5 2 2 2 493 55 7.11 2 2 25845407.88 2 metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;mitochondrion catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00035, Pf01207" 54920 ENSG00000167264.17 DUS2; DUS2L 16 tRNA modification in the nucleus and cytosol 0 High Q96NY9 Crossover junction endonuclease MUS81 OS=Homo sapiens OX=9606 GN=MUS81 PE=1 SV=3 0.001 3.924 8 2 2 2 551 61.1 9.73 2 2 1360449 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf02732 80198 ENSG00000172732.11 MUS81 11 Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Fanconi anemia pathway 0 Medium Q96IJ6 Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1 0.011 1.84 2 1 2 1 420 46.3 7.21 1 1 1 1 245008.6094 345272.125 1 1 metabolic process cytoplasm catalytic activity;protein binding "Pf00132, Pf00483, Pf12804" 29926 ENSG00000144591.18 GMPPA 2 Synthesis of GDP-mannose Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways 0 High Q92621 Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3 0 4.622 1 2 2 2 2012 227.8 6.19 1 1 1 1 578697.0625 561496.3125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;nucleus protein binding;structural molecule activity Pf11894 23165 ENSG00000155561.14 NUP205 7 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q8TF50 Zinc finger protein 526 OS=Homo sapiens OX=9606 GN=ZNF526 PE=2 SV=2 0 6.229 3 2 2 2 670 73.6 6.47 2 2 990959 2525072.688 1 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 116115 ENSG00000167625.10 ZNF526 19 0 High Q2M296 Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2 0 16.193 13 2 2 2 383 42.1 8.73 2 2 5283261.5 88010.64844 1 1 cytoplasm RNA binding "Pf00076, Pf01812, Pf14259" 64779 ENSG00000103248.18 MTHFSD 16 0 High P11802 Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2 0 5.958 7 2 2 1 303 33.7 7.01 1 1 1 1 313551.1563 612580.6875 201841.4219 724423.75 1 1 1 1 cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714" 1019 ENSG00000135446.16 CDK4 12 Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Ubiquitin-dependent degradation of Cyclin D1; Cyclin D associated events in G1; SCF(Skp2)-mediated degradation of p27/p21; Meiotic recombination; PTK6 Regulates Cell Cycle; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Transcriptional regulation by RUNX2; Oxidative Stress Induced Senescence Viral carcinogenesis; T cell receptor signaling pathway; Tight junction; Hepatitis B; Pancreatic cancer; Chronic myeloid leukemia; Non-small cell lung cancer; Breast cancer; Pathways in cancer; Glioma; AGE-RAGE signaling pathway in diabetic complications; Melanoma; HTLV-I infection; p53 signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Cell cycle; Endocrine resistance; PI3K-Akt signaling pathway 0 High P33240 Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1 0.002 2.895 3 2 2 2 577 60.9 6.83 2 2 1589196.125 574119.0625 2 1 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259, Pf14304, Pf14327" 1478 ENSG00000101811.13 CSTF2 X Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway; tRNA processing in the nucleus mRNA surveillance pathway 0 High P32780 General transcription factor IIH subunit 1 OS=Homo sapiens OX=9606 GN=GTF2H1 PE=1 SV=1 0 10.891 5 2 2 2 548 62 8.66 2 2 1072366.25 4800.509277 71321.21875 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;protein binding "Pf03909, Pf08567" 2965 ENSG00000110768.11 GTF2H1 11 Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; RNA Polymerase I Promoter Escape; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; Formation of Incision Complex in GG-NER; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Dual incision in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex Viral carcinogenesis; Basal transcription factors; Nucleotide excision repair 0 High Q9BRR3 Transmembrane protein 246 OS=Homo sapiens OX=9606 GN=TMEM246 PE=1 SV=1 0.001 3.31 7 2 2 2 403 46.6 7.59 2 2 1822303.625 408483.1875 1 1 membrane 84302 ENSG00000165152.8 TMEM246 9 0 High Q9UJX3 Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=4 0 8.427 4 2 2 2 599 66.8 5.64 1 1 1 1 173853.625 458322.2813 287709.3125 1 1 1 cell division;metabolic process;regulation of biological process cytosol;nucleus protein binding "Pf00515, Pf07719, Pf09674, Pf13414, Pf13432" 51434 ENSG00000196510.12 ANAPC7 12 APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP) Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 High P53007 "Tricarboxylate transport protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A1 PE=1 SV=2" 0 4.44 7 2 2 2 311 34 9.89 2 2 1848002.75 2 metabolic process;transport membrane;mitochondrion;nucleus transporter activity Pf00153 6576 ENSG00000100075.9 SLC25A1 22 Gluconeogenesis; Fatty acyl-CoA biosynthesis 0 High Q9NTW7 Zinc finger protein 64 OS=Homo sapiens OX=9606 GN=ZFP64 PE=1 SV=3 0 6.425 4 2 2 2 645 72.2 8.43 2 2 1912842.75 1935182.063 356663.7813 1 2 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf13465, Pf13912" 55734 ENSG00000020256.19 ZFP64 20 0 High Q9Y3T6 R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3 0 18.156 5 1 2 1 440 49.1 5.63 1 2 5492541.375 973808.4688 30334.88281 234476.0156 1 1 1 1 Met-loss+Acetyl [N-Term] Pf01424 203069 R3HCC1 8 0 High Q9UNM6 26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2 0.005 2.131 2 1 2 1 376 42.9 5.81 1 1 1 1 1409347.875 760198.9375 333941.4375 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;protein binding;structural molecule activity Pf01399 5719 ENSG00000185627.17 PSMD13 11 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 High P55735 Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3 0.004 2.394 3 1 2 1 322 35.5 5.48 1 1 1 1 4440358.5 1689674.25 1033213.188 1 1 1 cell organization and biogenesis;regulation of biological process;transport chromosome;cytosol;endoplasmic reticulum;membrane;nucleus;vacuole protein binding Pf00400 6396 ENSG00000157020.17 SEC13 3 "COPII (Coat Protein 2) Mediated Vesicle Transport; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RHO GTPases Activate Formins; MHC class II antigen presentation" Protein processing in endoplasmic reticulum; mTOR signaling pathway; RNA transport 0 High Q9BRJ2 "39S ribosomal protein L45, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" 0 4.759 6 2 2 2 306 35.3 9.03 2 2 22648780 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding Pf04280 84311 ENSG00000277936.4 MRPL45 17; CHR_HSCHR17_7_CTG4 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q92896 Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2 0.001 3.475 2 2 2 2 1179 134.5 6.9 1 1 1 1 140467.9063 1143287.625 259151.7813 115534.1719 1 1 1 1 cellular component movement;regulation of biological process Golgi;membrane protein binding Pf00839 2734 ENSG00000090863.11 GLG1 16 Cell surface interactions at the vascular wall Cell adhesion molecules (CAMs) 0 High O43819 "Protein SCO2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO2 PE=1 SV=3" 0.002 2.912 7 2 2 2 266 29.8 8.85 1 1 1 1 1778747 479664.7813 1141561.25 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport membrane;mitochondrion;organelle lumen antioxidant activity;catalytic activity;metal ion binding;protein binding "Pf00578, Pf02630, Pf13905" 9997 ENSG00000130489.14; ENSG00000284194.1 SCO2 22 TP53 Regulates Metabolic Genes; Respiratory electron transport Central carbon metabolism in cancer 0 High Q16513 Serine/threonine-protein kinase N2 OS=Homo sapiens OX=9606 GN=PKN2 PE=1 SV=1 0 7.746 2 2 2 2 984 112 6.3 2 2 273245.9336 12884588.25 2 2 cell death;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf00433, Pf02185, Pf07714, Pf14531" 5586 ENSG00000065243.19 PKN2 1 RHO GTPases activate PKNs Salmonella infection; PI3K-Akt signaling pathway 0 High A1L0T0 Acetolactate synthase-like protein OS=Homo sapiens OX=9606 GN=ILVBL PE=1 SV=2 0.002 2.823 3 2 2 2 632 67.8 8.15 2 2 744959.5 1127151.375 1 2 membrane catalytic activity;metal ion binding;protein binding "Pf00205, Pf02775, Pf02776" 10994 ENSG00000105135.15 ILVBL 19 0 High Q8WY91 THAP domain-containing protein 4 OS=Homo sapiens OX=9606 GN=THAP4 PE=1 SV=2 0 13.71 6 2 2 2 577 62.9 9.28 2 2 2081226.563 2 DNA binding;metal ion binding;protein binding "Pf05485, Pf08768" 51078 ENSG00000176946.11 THAP4 2 0 High Q15022 Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3 0 5.979 2 2 2 2 739 83 8.81 2 2 123274.8516 1208992.625 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding Pf09733 23512 ENSG00000178691.10 SUZ12 17 PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6; Regulation of PTEN gene transcription; PRC2 methylates histones and DNA; Oxidative Stress Induced Senescence 0 High O95568 Histidine protein methyltransferase 1 homolog OS=Homo sapiens OX=9606 GN=METTL18 PE=1 SV=1 0 9.372 9 2 2 2 372 42.1 6.76 2 2 8142.111816 1087291.125 438034.5625 181707.9844 1 1 1 1 metabolic process catalytic activity;protein binding "Pf05175, Pf06325, Pf10294, Pf12847" 92342 ENSG00000171806.11 METTL18 1 0 High Q15061 WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3 0 11.175 5 2 2 2 677 74.8 5.57 2 2 3726757.75 2091028.625 2 1 metabolic process;regulation of biological process nucleus protein binding;RNA binding "Pf00400, Pf04003" 23160 ENSG00000163811.11 WDR43 2 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High A6NHR9 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2 0 6.332 2 2 2 2 2005 226.2 7.3 2 2 180957.2031 1 cell organization and biogenesis;regulation of biological process chromosome catalytic activity;nucleotide binding;protein binding "Pf06470, Pf13589" 23347 ENSG00000101596.14 SMCHD1 18 0 High Q6NUN9 Zinc finger protein 746 OS=Homo sapiens OX=9606 GN=ZNF746 PE=1 SV=1 0.001 3.185 5 2 2 1 644 69.1 6.86 2 2 805814.375 304830.9688 1 1 metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf12417, Pf13465, Pf13894" 155061 ENSG00000181220.15 ZNF746 7 Generic Transcription Pathway 0 Low Q6X4W1 NMDA receptor synaptonuclear signaling and neuronal migration factor OS=Homo sapiens OX=9606 GN=NSMF PE=1 SV=1 0.063 1.012 1 1 2 1 530 60.1 9.07 1 2 16388.22852 1959307.625 822473.625 1 1 1 regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus protein binding 26012 ENSG00000165802.21 NELF; NSMF 9 0 High Q9H488 GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1 0 5.833 6 2 2 2 388 43.9 8.53 2 2 1045812.375 253483.75 1239731.469 1 1 2 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf10250 23509 ENSG00000101346.13 POFUT1 20 Pre-NOTCH Processing in the Endoplasmic Reticulum Other types of O-glycan biosynthesis 0 High Q9H009 Nascent polypeptide-associated complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=NACA2 PE=1 SV=1 0 7.091 7 1 2 1 215 23.2 4.73 1 1 1 1 2150768.25 530434.3125 634555.9375 1 1 1 transport cytoplasm;nucleus Pf01849 342538 ENSG00000253506.2 NACA2 17 0 High Q96T17 MAP7 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MAP7D2 PE=1 SV=2 0 6.842 5 2 2 2 732 81.9 8.84 2 2 1293461.5 1 cell organization and biogenesis cytoskeleton structural molecule activity Pf05672 256714 ENSG00000184368.15 MAP7D2 X 0 High P23458 Tyrosine-protein kinase JAK1 OS=Homo sapiens OX=9606 GN=JAK1 PE=1 SV=2 0.005 2.089 1 2 2 2 1154 133.2 7.55 2 2 195249.4531 4151194.25 1 2 cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714" 3716 ENSG00000162434.11 JAK1 1 Interleukin-15 signaling; ISG15 antiviral mechanism; IL-6-type cytokine receptor ligand interactions; MAPK3 (ERK1) activation; Interleukin-35 Signalling; Interleukin-10 signaling; Interleukin-7 signaling; G beta:gamma signalling through PI3Kgamma; Interleukin receptor SHC signaling; Other interleukin signaling; Regulation of IFNA signaling; GPVI-mediated activation cascade; Regulation of IFNG signaling; Interleukin-4 and 13 signaling; RAF/MAP kinase cascade; MAPK1 (ERK2) activation; Interleukin-9 signaling; Interleukin-20 family signaling Viral carcinogenesis; Th1 and Th2 cell differentiation; NOD-like receptor signaling pathway; Osteoclast differentiation; Hepatitis B; Pancreatic cancer; Epstein-Barr virus infection; Leishmaniasis; Pathways in cancer; Tuberculosis; EGFR tyrosine kinase inhibitor resistance; HTLV-I infection; Toxoplasmosis; Jak-STAT signaling pathway; Measles; Herpes simplex infection; Hepatitis C; Signaling pathways regulating pluripotency of stem cells; Influenza A; PI3K-Akt signaling pathway 0 High Q9H1C3 Glycosyltransferase 8 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GLT8D2 PE=2 SV=1 0 5.293 8 2 2 2 349 40 7.06 2 2 1317338.875 1707403.313 1 2 metabolic process Golgi;membrane catalytic activity Pf01501 83468 ENSG00000120820.12 GLT8D2 12 0 Medium P0DN81 Olfactory receptor 13C7 OS=Homo sapiens OX=9606 GN=OR13C7 PE=3 SV=1 0.037 1.296 2 1 2 1 318 34.9 8.75 1 2 148502.5781 1524948.125 1 1 regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity "Pf00001, Pf13853" 81377 OR13C7P; OR13C7 9 0 High Q15070 Mitochondrial inner membrane protein OXA1L OS=Homo sapiens OX=9606 GN=OXA1L PE=1 SV=3 0.005 2.086 2 1 2 1 435 48.5 9.45 1 2 70971.39844 1249587 1 1 cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion protein binding Pf02096 5018 OXA1L 14 Protein export 0 High P17096 High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3 0 6.578 25 2 2 2 107 11.7 10.32 2 2 6428237 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytosol;nucleus catalytic activity;DNA binding;protein binding 3159 ENSG00000137309.19 HMGA1 6 2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles; Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0 High Q9NWA0 Mediator of RNA polymerase II transcription subunit 9 OS=Homo sapiens OX=9606 GN=MED9 PE=1 SV=1 0.001 3.308 19 2 2 2 146 16.4 7.39 2 2 3391.727783 623189.9375 1 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus protein binding Pf07544 55090 ENSG00000141026.5 MED9 17 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High P17858 "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" 0 4.783 4 2 2 2 780 85 7.5 2 2 5260048 814624.375 974174.5 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00365 5211 ENSG00000141959.16 PFKL 21 Glycolysis; Neutrophil degranulation HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Galactose metabolism; Glucagon signaling pathway; Fructose and mannose metabolism; Pentose phosphate pathway; AMPK signaling pathway; Glycolysis / Gluconeogenesis; RNA degradation; Biosynthesis of amino acids; Metabolic pathways 0 High Q9NWQ4 G patch domain-containing protein 2-like OS=Homo sapiens OX=9606 GN=GPATCH2L PE=1 SV=3 0.001 3.71 4 1 2 1 482 54.2 8.44 1 2 Acetyl [N-Term] protein binding 55668 ENSG00000089916.17 GPATCH2L 14 0 High Q15388 Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1 0 5.111 19 2 2 2 145 16.3 8.6 2 2 994134.4629 7890031.5 528525.4375 2 2 1 cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity Pf02064 9804 ENSG00000173726.10 TOMM20 1 Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy 0 High O14929 Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=1 0.001 3.528 6 2 2 2 419 49.5 5.69 2 2 968335.2813 396775.4063 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;protein binding Pf10394 8520 HAT1 2 HATs acetylate histones Alcoholism 0 Medium Q8N2M4 Lysoplasmalogenase-like protein TMEM86A OS=Homo sapiens OX=9606 GN=TMEM86A PE=2 SV=1 0.048 1.13 3 1 2 1 240 26.4 8.65 1 1 1 1 224642.125 604494.4375 392932.8125 1 1 1 membrane Pf07947 144110 ENSG00000151117.8 TMEM86A 11 0 High Q9NX04 Uncharacterized protein C1orf109 OS=Homo sapiens OX=9606 GN=C1ORF109 PE=1 SV=1 0 7.657 19 2 2 2 203 23.4 5.67 2 2 2832153.75 514093.3438 59678.20703 1 1 1 Met-loss+Acetyl [N-Term] cytoplasm;nucleus protein binding Pf15011 54955 ENSG00000116922.14 C1orf109 1 0 High Q96Q45 Transmembrane protein 237 OS=Homo sapiens OX=9606 GN=TMEM237 PE=1 SV=2 0 8.389 7 2 2 2 408 45.5 6.47 2 2 1529221.625 1 cell organization and biogenesis;regulation of biological process membrane protein binding Pf15383 65062 ENSG00000155755.18 TMEM237 2 0 High Q9P109 "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 OS=Homo sapiens OX=9606 GN=GCNT4 PE=2 SV=1" 0.002 3.059 4 1 2 1 453 53 8.25 1 2 135348345 587142.8125 2750464.188 1 1 1 metabolic process;response to stimulus Golgi;membrane catalytic activity Pf02485 51301 ENSG00000176928.5 GCNT4 5 O-linked glycosylation of mucins Mucin type O-glycan biosynthesis; Metabolic pathways 0 High Q8NB50 Zinc finger protein 62 homolog OS=Homo sapiens OX=9606 GN=ZFP62 PE=1 SV=3 0 7.987 3 2 2 2 900 102.4 9.04 2 2 77147.88281 2004365.75 1 2 metabolic process;regulation of biological process nucleus metal ion binding Pf13465 643836 ENSG00000196670.13 ZFP62 5 0 High O96028 Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1 0 6.054 2 2 2 2 1365 152.2 8.69 2 2 2477510.75 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00505, Pf00628, Pf00855, Pf00856" 7468 ENSG00000109685.17 WHSC1; NSD2 4 G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; PKMTs methylate histone lysines; Nonhomologous End-Joining (NHEJ) Lysine degradation; Transcriptional misregulation in cancer 0 High Q9NPC8 Homeobox protein SIX2 OS=Homo sapiens OX=9606 GN=SIX2 PE=1 SV=1 0 4.887 14 2 2 1 291 32.3 9.01 2 2 279183.8438 1 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;transport nucleus DNA binding;protein binding "Pf00046, Pf05920" 10736 ENSG00000170577.7 SIX2 2 0 High Q6ZNG2 Homeobox protein DBX2 OS=Homo sapiens OX=9606 GN=DBX2 PE=2 SV=2 0.004 2.162 2 1 2 1 339 36.5 9.35 1 2 2550461 1 regulation of biological process nucleus DNA binding Pf00046 440097 ENSG00000185610.6 DBX2 12 0 High Q8IXI1 Mitochondrial Rho GTPase 2 OS=Homo sapiens OX=9606 GN=RHOT2 PE=1 SV=2 0.002 2.897 1 1 2 1 618 68.1 5.86 1 1 1 1 973061.25 787135.0625 563819.25 1 1 1 cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00071, Pf01926, Pf08355, Pf08356, Pf08477, Pf13479" 89941 ENSG00000140983.13 RHOT2 16 Rho GTPase cycle 0 High P02545 Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1 0 5.669 3 2 2 2 664 74.1 7.02 2 2 703290.625 964944.625 1238093.375 1 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf00932" 4000 ENSG00000160789.19 LMNA 1 Signaling by BRAF and RAF fusions; Breakdown of the nuclear lamina; XBP1(S) activates chaperone genes; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Depolymerisation of the Nuclear Lamina; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Apoptosis; Hypertrophic cardiomyopathy (HCM) 0 High Q96GY0 Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2 0 5.496 6 2 2 2 325 35.1 9.82 2 2 3892973.25 256880.9375 2 1 metal ion binding;protein binding Pf13913 51101 ENSG00000104427.11 ZC2HC1A 8 0 High P10643 Complement component C7 OS=Homo sapiens OX=9606 GN=C7 PE=1 SV=2 0 5.193 3 2 2 2 843 93.5 6.48 1 1 1 1 2080386.25 1064222.25 2 2 cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus extracellular protein binding "Pf00084, Pf01823" 730 ENSG00000112936.18 C7 5 Terminal pathway of complement; Regulation of Complement cascade Prion diseases; Complement and coagulation cascades; Systemic lupus erythematosus 0 High P54802 Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 0 5.286 5 2 2 2 743 82.2 6.65 2 2 1530233.563 2 cell organization and biogenesis;metabolic process;response to stimulus organelle lumen;vacuole catalytic activity "Pf05089, Pf12971, Pf12972" 4669 ENSG00000108784.9 NAGLU 17 MPS IIIB - Sanfilippo syndrome B; HS-GAG degradation Lysosome; Glycosaminoglycan degradation; Metabolic pathways 0 High P09493 Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2 0.001 3.647 9 2 2 1 284 32.7 4.74 2 2 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity "Pf00261, Pf12718" 7168 ENSG00000140416.19 TPM1 15 Smooth Muscle Contraction; Striated Muscle Contraction Dilated cardiomyopathy; MicroRNAs in cancer; Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM) 0 High Q9NW08 DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2 0 6.718 2 2 2 2 1133 127.7 8.5 2 2 75151.84375 3230497.375 1 2 defense response;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;metal ion binding "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" 55703 ENSG00000013503.9 POLR3B 12 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q8NF99 Zinc finger protein 397 OS=Homo sapiens OX=9606 GN=ZNF397 PE=1 SV=2 0.001 3.716 5 1 2 1 534 61.1 7.27 1 2 1135365.875 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf02023, Pf13465" 84307 ENSG00000186812.12 ZNF397 18 0 High Q12874 Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1 0 7.371 4 2 2 2 501 58.8 5.38 2 2 3864757.75 2 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf11931, Pf12108, Pf13297" 10946 ENSG00000183431.11 SF3A3 1 mRNA Splicing - Major Pathway Spliceosome 0 High Q9UHR4 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Homo sapiens OX=9606 GN=BAIAP2L1 PE=1 SV=2 0.001 3.627 6 2 2 2 511 56.8 8.68 2 2 650936.875 1366216.125 1675136.586 2 1 2 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding "Pf00018, Pf07653, Pf08397, Pf14604" 55971 ENSG00000006453.13 BAIAP2L1 7 0 High Q96KA5 Cleft lip and palate transmembrane protein 1-like protein OS=Homo sapiens OX=9606 GN=CLPTM1L PE=1 SV=1 0 4.321 4 2 2 2 538 62.2 8.56 2 2 847950.75 2 cell death membrane Pf05602 81037 ENSG00000274811.3; ENSG00000049656.13 CLPTM1L 5; CHR_HSCHR5_3_CTG1 0 High Q9Y6Q3 Zinc finger protein 37 homolog OS=Homo sapiens OX=9606 GN=ZFP37 PE=2 SV=3 0 14.031 2 1 2 1 630 71.2 9.09 1 2 10820542 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 7539 ENSG00000136866.13 ZFP37 9 Generic Transcription Pathway 0 Medium Q9UM73 ALK tyrosine kinase receptor OS=Homo sapiens OX=9606 GN=ALK PE=1 SV=3 0.035 1.309 0 1 2 1 1620 176.3 7.08 1 1 1 1 2033252.75 500649.5 1 1 cell proliferation;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00069, Pf00629, Pf07714, Pf14531, Pf14670" 238 ENSG00000171094.16 ALK 2 Non-small cell lung cancer 0 High Q8IWA0 WD repeat-containing protein 75 OS=Homo sapiens OX=9606 GN=WDR75 PE=1 SV=1 0 4.956 2 2 2 2 830 94.4 5.96 2 2 719844.875 1 metabolic process;regulation of biological process nucleus protein binding;RNA binding Pf00400 84128 ENSG00000115368.9 WDR75 2 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q6PK81 Zinc finger protein 773 OS=Homo sapiens OX=9606 GN=ZNF773 PE=2 SV=1 0 6.562 5 2 2 1 442 50.5 8.94 2 2 1648736.125 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 374928 ENSG00000152439.12 ZNF773 19 Generic Transcription Pathway 0 High Q96P47 "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=AGAP3 PE=1 SV=2" 0 6.685 3 2 2 2 875 95 7.97 1 1 1 1 160314.2344 1204214 2462197 1128760.25 1 1 1 1 regulation of biological process;response to stimulus cytoplasm;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00023, Pf00071, Pf00169, Pf01412, Pf08477, Pf12796, Pf13637, Pf13857" 116988 ENSG00000133612.18 AGAP3 7 Endocytosis 0 High Q9Y6C9 Mitochondrial carrier homolog 2 OS=Homo sapiens OX=9606 GN=MTCH2 PE=1 SV=1 0 4.469 8 2 2 2 303 33.3 7.97 2 2 759365 1025042.469 1 2 regulation of biological process;transport membrane;mitochondrion;nucleus Pf00153 23788 ENSG00000109919.9 MTCH2 11 0 High Q6UB35 "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" 0.007 1.967 1 1 2 1 978 105.7 8.06 1 1 1 1 647093.75 855218.9375 459521.5313 244935.6875 1 1 1 1 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00763, Pf01268, Pf02882" 25902 ENSG00000120254.15 MTHFD1L 6 Metabolism of folate and pterines One carbon pool by folate; Metabolic pathways 0 High Q6AW86 Zinc finger protein 324B OS=Homo sapiens OX=9606 GN=ZNF324B PE=1 SV=1 0 11.883 6 2 2 2 544 60.6 9.69 2 2 3738264 936678.25 971653.3125 2 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf09723, Pf13465" 388569 ENSG00000249471.7 ZNF324B 19 Generic Transcription Pathway 0 High Q5TYW1 Zinc finger protein 658 OS=Homo sapiens OX=9606 GN=ZNF658 PE=1 SV=2 0 6.64 3 2 2 2 1059 122.2 8.28 2 2 2431998.5 331955.0938 1 1 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 26149 ENSG00000274349.4 ZNF658 9 Generic Transcription Pathway 0 High P00734 Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 SV=2 0.002 2.826 1 1 2 1 622 70 5.9 1 1 1 1 2809375 3699958 735830.25 657251.125 1 1 1 1 cellular component movement;cellular homeostasis;coagulation;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00051, Pf00089, Pf00594, Pf09342, Pf09396" 2147 ENSG00000180210.14 F2 11 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Peptide ligand-binding receptors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors; Thrombin signalling through proteinase activated receptors (PARs); Platelet Aggregation (Plug Formation); Regulation of Complement cascade; Common Pathway of Fibrin Clot Formation; Gastrin-CREB signalling pathway via PKC and MAPK; Cell surface interactions at the vascular wall Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Regulation of actin cytoskeleton 0 High Q92504 Zinc transporter SLC39A7 OS=Homo sapiens OX=9606 GN=SLC39A7 PE=1 SV=2 0 8.226 3 1 2 1 469 50.1 6.87 1 2 2993656 204398.1406 1 1 cellular homeostasis;transport endoplasmic reticulum;Golgi;membrane protein binding;transporter activity Pf02535 7922 ENSG00000227402.11; ENSG00000112473.17; ENSG00000206288.13; ENSG00000226614.11; ENSG00000224399.11; ENSG00000229802.11 SLC39A7 6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1 Zinc influx into cells by the SLC39 gene family 0 High Q9UHK0 Nuclear fragile X mental retardation-interacting protein 1 OS=Homo sapiens OX=9606 GN=NUFIP1 PE=1 SV=2 0.001 3.572 3 2 2 2 495 56.3 9.13 2 2 837485.375 11657464 534359.875 191961.7813 1 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus;ribosome DNA binding;metal ion binding;protein binding;RNA binding "Pf10453, Pf12171" 26747 ENSG00000083635.7 NUFIP1 13 0 High P85037 Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1 0.001 3.934 2 2 2 2 733 75.4 9.32 1 1 1 1 87743.9375 4342251 564749.875 1 2 1 cell differentiation;development;metabolic process;regulation of biological process nucleus DNA binding;protein binding "Pf00250, Pf00498" 221937 ENSG00000164916.10 FOXK1 7 UCH proteinases 0 High Q04323 UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2 0.001 4.051 6 2 2 2 297 33.3 5.25 1 1 1 1 536944 1410525.25 894913.5 1 2 2 metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;nucleus;proteasome protein binding "Pf00627, Pf00789" 51035 ENSG00000162191.13 UBXN1 11 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0 High Q96G46 tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2 0 7.013 5 2 2 2 650 72.5 8.05 2 2 metabolic process catalytic activity;metal ion binding;nucleotide binding;RNA binding Pf01207 56931 ENSG00000141994.15 DUS3L 19 0 High Q9BUQ8 Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3 0 5.509 2 2 2 2 820 95.5 9.55 2 2 3442135.75 2 cell organization and biogenesis;metabolic process cytoplasm;nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 9416 ENSG00000174243.9 DDX23 12 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High O96005 Cleft lip and palate transmembrane protein 1 OS=Homo sapiens OX=9606 GN=CLPTM1 PE=1 SV=1 0.001 3.766 6 2 2 2 669 76 6.3 2 2 2572.49707 875329.9375 572699.5 1 1 1 cell differentiation;development;regulation of biological process membrane protein binding Pf05602 1209 ENSG00000104853.15 CLPTM1 19 0 High Q07866 Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2 0.001 3.875 4 2 2 2 573 65.3 6.2 2 2 665792.5625 5087803.5 2 2 cell organization and biogenesis;cellular component movement;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;protein binding "Pf08317, Pf09311, Pf13374, Pf13414, Pf13424, Pf13432, Pf14559" 3831 ENSG00000126214.21 KLC1 14 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1; MHC class II antigen presentation Salmonella infection 0 High Q9H3G5 Probable serine carboxypeptidase CPVL OS=Homo sapiens OX=9606 GN=CPVL PE=1 SV=2 0 4.805 6 2 2 2 476 54.1 5.62 1 1 1 1 194925.2188 360429.7813 1 1 metabolic process catalytic activity Pf00450 54504 ENSG00000106066.14 CPVL 7 0 High Q6UN15 Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1 0 9.504 5 2 2 2 594 66.5 5.59 2 2 5697967.5 2275471.75 4017153.75 2 1 1 metabolic process;transport nucleus protein binding;RNA binding Pf05182 81608 ENSG00000145216.15 FIP1L1 4 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs mRNA surveillance pathway 0 High P13987 CD59 glycoprotein OS=Homo sapiens OX=9606 GN=CD59 PE=1 SV=1 0 6.507 16 2 2 2 128 14.2 6.48 2 2 2528924.563 2078254.188 342812.6563 2 2 2 cell organization and biogenesis;coagulation;regulation of biological process;response to stimulus;transport cell surface;extracellular;membrane protein binding Pf00021 966 ENSG00000085063.14 CD59 11 Regulation of Complement cascade; Neutrophil degranulation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport Hematopoietic cell lineage; Complement and coagulation cascades 0 High Q99720 Sigma non-opioid intracellular receptor 1 OS=Homo sapiens OX=9606 GN=SIGMAR1 PE=1 SV=1 0.001 3.547 6 1 2 1 223 25.1 5.96 1 2 1626323.5 1972877.5 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane;nucleus protein binding;receptor activity;signal transducer activity Pf04622 10280 ENSG00000147955.16 SIGMAR1 9 0 Low Q9P2D0 Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3 0.066 0.966 1 1 2 1 1353 150.4 7.71 1 1 1 1 62865236 42593808 225935312 1 1 1 cellular homeostasis;regulation of biological process;transport cytoplasm;membrane;nucleus enzyme regulator activity;protein binding "Pf00023, Pf00415, Pf00651, Pf12796, Pf13254, Pf13540, Pf13637, Pf13857" 25998 ENSG00000283068.1; ENSG00000005700.14 IBTK 6; CHR_HG2072_PATCH 0 High P12277 Creatine kinase B-type OS=Homo sapiens OX=9606 GN=CKB PE=1 SV=1 0 6.112 11 2 2 2 381 42.6 5.59 2 2 8478771 2141414.938 731130.25 1 2 1 cellular homeostasis;metabolic process cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf00217, Pf02807" 1152 ENSG00000166165.12 CKB 14 Creatine metabolism Metabolic pathways; Arginine and proline metabolism 0 Medium Q13049 E3 ubiquitin-protein ligase TRIM32 OS=Homo sapiens OX=9606 GN=TRIM32 PE=1 SV=2 0.027 1.471 2 1 2 1 653 71.9 6.98 1 1 1 1 217525.6563 357017.4688 1 1 cell differentiation;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00643, Pf01436, Pf10186, Pf13445, Pf13639, Pf13920, Pf13923, Pf14570, Pf14634, Pf15227" 22954 ENSG00000119401.10 TRIM32 9 Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA Ubiquitin mediated proteolysis 0 High Q16706 Alpha-mannosidase 2 OS=Homo sapiens OX=9606 GN=MAN2A1 PE=1 SV=2 0.001 3.797 2 2 2 2 1144 131.1 7.58 2 2 330132.8125 1 cell organization and biogenesis;metabolic process;regulation of biological process Golgi;membrane catalytic activity;metal ion binding "Pf01074, Pf07748, Pf09261" 4124 ENSG00000112893.9 MAN2A1 5 Intra-Golgi traffic; Reactions specific to the complex N-glycan synthesis pathway N-Glycan biosynthesis; Metabolic pathways 0 High Q9Y6D6 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2 0 5.098 1 1 2 1 1849 208.6 5.85 1 1 1 1 622218.125 579961.5625 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;nucleus enzyme regulator activity;protein binding "Pf01369, Pf09324, Pf12783" 10565 ENSG00000066777.8 ARFGEF1 8 Endocytosis 0 High Q8TAE8 Growth arrest and DNA damage-inducible proteins-interacting protein 1 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1 0 4.809 8 2 2 2 222 25.4 10.02 2 2 2394616.125 1154566.875 773352 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen;ribosome protein binding Pf10147 90480 ENSG00000179271.2 GADD45GIP1 19 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q92785 Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2 0 5.076 6 2 2 2 391 44.1 6.33 1 1 1 1 3942450.203 400807.375 2 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;metal ion binding;protein binding "Pf00628, Pf14051" 5977 ENSG00000133884.9 DPF2 11 0 High P49761 Dual specificity protein kinase CLK3 OS=Homo sapiens OX=9606 GN=CLK3 PE=1 SV=3 0 8.014 5 2 2 2 638 73.5 9.92 2 2 3356161.625 2 metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf07714" 1198 ENSG00000179335.18 CLK3 15 0 High P57075 Ubiquitin-associated and SH3 domain-containing protein A OS=Homo sapiens OX=9606 GN=UBASH3A PE=1 SV=1 0.001 3.871 2 1 2 1 661 74.1 7.66 1 1 1 1 165397.3594 1235061888 1009095.875 1 1 1 regulation of biological process cytoplasm;cytosol;nucleus protein binding "Pf00018, Pf00300, Pf07653, Pf14604" 53347 ENSG00000160185.14 UBASH3A 21 0 High Q13444 Disintegrin and metalloproteinase domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ADAM15 PE=1 SV=4 0 6.196 3 2 2 2 863 92.9 6.73 2 2 1598162.875 8220406 4407495.25 1 1 2 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;membrane catalytic activity;metal ion binding;protein binding "Pf00200, Pf00413, Pf01421, Pf01562, Pf08516, Pf13574, Pf13582, Pf13583, Pf13688" 8751 ENSG00000143537.13 ADAM15 1 Degradation of the extracellular matrix; Invadopodia formation 0 Low Q8TAP6 Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1 0.071 0.91 1 1 2 1 659 74.4 6.74 1 2 21471278 1 regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding Pf15627 79959 ENSG00000101624.10 CEP76 18 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High Q9BVK6 Transmembrane emp24 domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TMED9 PE=1 SV=2 0 4.397 7 2 2 2 235 27.3 8.02 1 1 1 1 940898.75 2021752 2354950.5 1 1 2 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding Pf01105 54732 ENSG00000184840.11 TMED9 5 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport 0 High A8CG34 Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3 0 5.582 2 2 2 2 1229 125 10.37 2 2 306398.5938 6261173.75 1 2 0 High Q96CX2 BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1 0 5.947 6 2 2 2 325 35.7 5.64 2 2 7721773.5 2950151.25 719969.75 1 1 1 cell organization and biogenesis;transport membrane protein binding;RNA binding;transporter activity Pf02214 115207 ENSG00000178695.5 KCTD12 13 0 High Q15843 NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1 0 8.621 17 1 2 1 81 9.1 8.43 1 2 1354849.5 5917658.625 4848885.938 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding "Pf00240, Pf11976" 4738 ENSG00000129559.12 NEDD8 14 Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; TGF-beta receptor signaling activates SMADs; Iron uptake and transport; Neddylation 0 High P51530 DNA replication ATP-dependent helicase/nuclease DNA2 OS=Homo sapiens OX=9606 GN=DNA2 PE=1 SV=3 0 7.777 2 2 2 2 1060 120.3 7.74 2 2 2106019.25 1097.026855 2 1 Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf08696, Pf13086, Pf13087, Pf13245, Pf13604" 1763 ENSG00000138346.14 DNA2 10 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; Removal of the Flap Intermediate from the C-strand; Resolution of D-loop Structures through Holliday Junction Intermediates DNA replication 0 High Q6P2D0 Zinc finger protein 1 homolog OS=Homo sapiens OX=9606 GN=ZFP1 PE=1 SV=2 0 8.145 6 2 2 2 407 47.5 8.57 2 2 1327157.375 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 162239 ENSG00000184517.11 ZFP1 16 Generic Transcription Pathway 0 High Q96SB8 Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2 0 9.295 3 2 2 2 1091 126.2 6.99 2 2 1545757.125 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoskeleton;nucleus nucleotide binding;protein binding;transporter activity "Pf01496, Pf02463, Pf04111, Pf04156, Pf06160, Pf12128" 79677 ENSG00000163029.15 SMC6 2 SUMOylation of DNA damage response and repair proteins 0 High Q96HR3 Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1 0.001 3.946 7 1 2 1 178 20.3 8.27 1 1 1 1 1288507.625 875263.5625 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;protein binding;receptor activity Pf11315 90390 ENSG00000164758.7 MED30 8 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High P29590 Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3 0.006 2.045 1 1 2 1 882 97.5 6.21 1 2 261845.4844 1 cell death;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane;nucleus DNA binding;metal ion binding;protein binding "Pf00097, Pf00643, Pf12126, Pf13639, Pf13920, Pf14634, Pf14835" 5371 ENSG00000140464.19 PML 15 Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of RUNX1 Expression and Activity; SUMOylation of DNA damage response and repair proteins; Regulation of PTEN localization Endocytosis; Ubiquitin mediated proteolysis; Acute myeloid leukemia; Pathways in cancer; Transcriptional misregulation in cancer; Herpes simplex infection; Influenza A 0 High Q96I51 RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=2 0 16.188 11 2 2 2 464 50 8.4 2 2 2338750.688 1970071.25 601476.875 2 1 1 mitochondrion RNA binding "Pf00415, Pf13540" 81554 WBSCR16; RCC1L 7 0 High Q6ZXV5 Protein O-mannosyl-transferase TMTC3 OS=Homo sapiens OX=9606 GN=TMTC3 PE=1 SV=2 0 6.508 2 2 2 2 915 103.9 8.87 2 2 1432635 225902.7656 2 1 regulation of biological process;response to stimulus endoplasmic reticulum;membrane protein binding "Pf00515, Pf07719, Pf08409, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559" 160418 TMTC3 12 0 High Q8NC60 Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2 0 8.993 5 2 2 2 698 78.4 8.66 2 2 11141798 2977638 363543.3125 385796.9375 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf01926, Pf02421, Pf03193" 84273 ENSG00000084092.6 NOA1 4 0 High O95573 Long-chain-fatty-acid--CoA ligase 3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=3 0.001 3.651 4 2 2 2 720 80.4 8.38 1 1 1 1 386173.5625 715919.3125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding Pf00501 2181 ENSG00000123983.13 ACSL3 2 Synthesis of very long-chain fatty acyl-CoAs Peroxisome; Fatty acid degradation; PPAR signaling pathway; Fatty acid biosynthesis; Metabolic pathways; Adipocytokine signaling pathway; Fatty acid metabolism 0 High O60341 Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2 0 4.879 3 2 2 2 852 92.8 6.52 1 1 1 1 292925.6563 350884.375 1 1 cell organization and biogenesis;coagulation;development;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf01593, Pf04433, Pf13450, Pf13870" 23028 ENSG00000004487.15 KDM1A 1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Regulation of PTEN gene transcription; HDACs deacetylate histones; HDMs demethylate histones; Factors involved in megakaryocyte development and platelet production 0 High Q5VZL5 Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1 0 5.334 2 2 2 2 1548 172.7 6.84 1 1 1 1 672175.25 1 cell organization and biogenesis;development;regulation of biological process cytoplasm DNA binding;metal ion binding;protein binding "Pf06467, Pf12012" 9202 ENSG00000146463.11 ZMYM4 1 0 High Q9Y2G5 GDP-fucose protein O-fucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POFUT2 PE=1 SV=3 0.001 3.253 7 2 2 2 429 49.9 6.6 2 2 3600899.25 165427.0938 614346.75 1 1 1 metabolic process;regulation of biological process endoplasmic reticulum;Golgi;membrane catalytic activity Pf10250 23275 ENSG00000186866.16 POFUT2 21 O-glycosylation of TSR domain-containing proteins Other types of O-glycan biosynthesis 0 High Q53T94 TATA box-binding protein-associated factor RNA polymerase I subunit B OS=Homo sapiens OX=9606 GN=TAF1B PE=1 SV=1 0 15.271 6 2 2 2 588 68.8 8.02 2 2 3687801.5 2 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding Pf11781 9014 ENSG00000115750.16 TAF1B 2 SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation 0 High Q9HD45 Transmembrane 9 superfamily member 3 OS=Homo sapiens OX=9606 GN=TM9SF3 PE=1 SV=2 0 4.76 3 2 2 2 589 67.8 7.21 2 2 725991.9375 2567024.375 1 2 membrane Pf02990 56889 ENSG00000077147.14 TM9SF3 10 0 High Q96J01 THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1 0 6.297 7 1 1 1 351 38.7 6.09 1 1 metabolic process;transport nucleus protein binding;RNA binding "Pf00400, Pf08662" 84321 ENSG00000051596.9 THOC3 5 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing Spliceosome; RNA transport 0 Medium Q15648 Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4 0.015 1.687 1 1 1 1 1581 168.4 8.73 1 1 554718.25 1 cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport chromosome;membrane;nucleus catalytic activity;DNA binding;protein binding;receptor activity Pf10744 5469 ENSG00000125686.11 MED1 17 "Nuclear Receptor transcription pathway; Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; RORA activates gene expression; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription" Thyroid hormone signaling pathway; Endocrine resistance 0 High Q5JVS0 Intracellular hyaluronan-binding protein 4 OS=Homo sapiens OX=9606 GN=HABP4 PE=1 SV=1 0.002 3.057 6 1 1 1 413 45.8 7.46 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus protein binding;RNA binding Pf04774 22927 ENSG00000130956.13 HABP4 9 Platelet degranulation 0 High Q92759 General transcription factor IIH subunit 4 OS=Homo sapiens OX=9606 GN=GTF2H4 PE=1 SV=1 0 4.423 4 1 1 1 462 52.2 9.04 1 1 1922274.5 22028.08594 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding "Pf03849, Pf13625" 2968 ENSG00000226384.10; ENSG00000221974.11; ENSG00000233149.10; ENSG00000234370.10; ENSG00000236895.10; ENSG00000213780.10 GTF2H4 6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1 Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; RNA Polymerase I Promoter Escape; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; Formation of Incision Complex in GG-NER; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Dual incision in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex Viral carcinogenesis; Basal transcription factors; Nucleotide excision repair 0 High Q7Z569 BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2 0.006 2.044 2 1 1 1 592 67.3 5.92 1 1 850272.6875 474992.75 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00097, Pf02148, Pf02841, Pf07576, Pf12128, Pf12678, Pf12718, Pf12861, Pf13639, Pf13923, Pf14634" 8315 ENSG00000089234.15 BRAP 12 Paradoxical activation of RAF signaling by kinase inactive BRAF; Negative regulation of MAPK pathway; RAF activation; Signaling by RAS mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling Ras signaling pathway 0 Medium Q96F81 Protein dispatched homolog 1 OS=Homo sapiens OX=9606 GN=DISP1 PE=1 SV=3 0.034 1.359 1 1 1 1 1524 170.8 6.89 1 1 3530004 2712306.75 891048.75 1 1 1 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport membrane protein binding;transporter activity "Pf02460, Pf03176, Pf12349" 84976 ENSG00000154309.8 DISP1 1 0 High Q9BUZ4 TNF receptor-associated factor 4 OS=Homo sapiens OX=9606 GN=TRAF4 PE=1 SV=1 0.001 4.285 3 1 1 1 470 53.5 8.15 1 1 909036.5 1 cell death;development;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus DNA binding;metal ion binding;protein binding "Pf00097, Pf00917, Pf02176, Pf13923" 9618 ENSG00000076604.14 TRAF4 17 Pathways in cancer; Small cell lung cancer 0 High Q969F1 General transcription factor 3C polypeptide 6 OS=Homo sapiens OX=9606 GN=GTF3C6 PE=1 SV=1 0 5.088 7 1 1 1 213 24 4.21 1 1 372988.5 1701342.375 7388.591309 1 1 1 metabolic process nucleus DNA binding;protein binding Pf10419 112495 ENSG00000155115.6 GTF3C6 6 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 Low Q7L8L6 "FAST kinase domain-containing protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD5 PE=1 SV=1" 0.05 1.105 1 1 1 1 764 86.5 8.13 1 1 335663.8438 1 cell organization and biogenesis;metabolic process mitochondrion catalytic activity;protein binding;RNA binding "Pf06743, Pf08368, Pf08373" 60493 ENSG00000215251.3 FASTKD5 20 0 High P25788 Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2 0.006 2.043 4 1 1 1 255 28.4 5.33 1 1 706113.5625 639096.9375 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;nucleotide binding;protein binding "Pf00227, Pf10584" 5684 ENSG00000100567.12 PSMA3 14 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q13501 Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1 0 5.224 6 1 1 1 440 47.7 5.22 1 1 738406.125 1 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;nucleus;vacuole catalytic activity;metal ion binding;protein binding "Pf00564, Pf00569" 8878 ENSG00000161011.19 SQSTM1 5 Interleukin-1 family signaling; NF-kB is activated and signals survival; Signalling by NGF; p75NTR recruits signalling complexes; NRIF signals cell death from the nucleus; Pink/Parkin Mediated Mitophagy Osteoclast differentiation 0 Low Q6ZT89 Solute carrier family 25 member 48 OS=Homo sapiens OX=9606 GN=SLC25A48 PE=1 SV=2 0.058 1.045 3 1 1 1 311 33.4 8.69 1 1 804792.9375 1 transport membrane;mitochondrion protein binding;transporter activity "Pf00153, Pf05619" 153328 SLC25A48 5 0 Medium P62191 26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1 0.014 1.773 3 1 1 1 440 49.2 6.21 1 1 9076356 677379.8125 513706.7188 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf05673, Pf05729, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401" 5700 ENSG00000100764.13 PSMC1 14 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Viral carcinogenesis; Epstein-Barr virus infection; Proteasome 0 Low Q13315 Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4 0.065 0.974 0 1 1 1 3056 350.5 6.81 1 1 5223887.5 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;transporter activity "Pf00454, Pf02259, Pf02260, Pf11640" 472 ENSG00000149311.18 ATM 11 TP53 Regulates Transcription of Caspase Activators and Caspases; Nonhomologous End-Joining (NHEJ); TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates; G2/M DNA damage checkpoint; Regulation of HSF1-mediated heat shock response; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Methylation; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Autodegradation of the E3 ubiquitin ligase COP1; Sensing of DNA Double Strand Breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); DNA Damage/Telomere Stress Induced Senescence; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FoxO signaling pathway; Homologous recombination; MicroRNAs in cancer; NF-kappa B signaling pathway; HTLV-I infection; Apoptosis; Transcriptional misregulation in cancer; p53 signaling pathway; Cell cycle; Platinum drug resistance 0 Low Q8IYL2 Probable tRNA (uracil-O(2)-)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT44 PE=1 SV=2 0.072 0.905 1 1 1 1 757 84.6 7.27 1 1 5470172.5 1 metabolic process cytoplasm catalytic activity;metal ion binding "Pf07757, Pf13679" 152992 ENSG00000155275.18 TRMT44 4 tRNA modification in the nucleus and cytosol 0 Medium Q96SQ5 Zinc finger protein 587 OS=Homo sapiens OX=9606 GN=ZNF587 PE=1 SV=1 0.015 1.726 2 1 1 1 575 65.6 8.92 1 1 2539223.75 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf01352, Pf13465" 84914 ENSG00000198466.11 ZNF587 19 Generic Transcription Pathway 0 High Q9Y580 RNA-binding protein 7 OS=Homo sapiens OX=9606 GN=RBM7 PE=1 SV=1 0.003 2.67 3 1 1 1 266 30.5 9.57 1 1 27437.75781 1202843.5 1 1 regulation of biological process nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10179 ENSG00000076053.10 RBM7 11 0 Medium Q8NEW0 Zinc transporter 7 OS=Homo sapiens OX=9606 GN=SLC30A7 PE=2 SV=1 0.011 1.857 3 1 1 1 376 41.6 6.95 1 1 454773.6563 846107.9375 1 1 regulation of biological process;response to stimulus;transport cytoplasm;Golgi;membrane transporter activity Pf01545 148867 ENSG00000162695.11 SLC30A7 1 Insulin processing; Zinc efflux and compartmentalization by the SLC30 family 0 High Q8NI77 Kinesin-like protein KIF18A OS=Homo sapiens OX=9606 GN=KIF18A PE=1 SV=2 0 4.52 2 1 1 1 898 102.2 8.91 1 1 682430 1842769 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding Pf00225 81930 ENSG00000121621.6 KIF18A 11 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation 0 High O60784 Target of Myb protein 1 OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2 0.001 3.341 5 1 1 1 492 53.8 4.7 1 1 696021.75 142634.8125 1 1 transport cytoplasm;cytosol;endosome;membrane protein binding "Pf00790, Pf03127" 10043 ENSG00000100284.20 TOM1 22 Neutrophil degranulation 0 High Q13574 Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=3 0 7.25 2 1 1 1 1117 124.1 9.04 1 1 1796715.625 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00023, Pf00130, Pf00609, Pf00781, Pf12796, Pf13637, Pf13857" 8525 ENSG00000149091.15 DGKZ 11 Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK Phospholipase D signaling pathway; Glycerolipid metabolism; Phosphatidylinositol signaling system; Choline metabolism in cancer; Glycerophospholipid metabolism; Metabolic pathways 0 Medium P45877 Peptidyl-prolyl cis-trans isomerase C OS=Homo sapiens OX=9606 GN=PPIC PE=1 SV=1 0.034 1.351 3 1 1 1 212 22.7 8.4 1 1 6325124.5 940635.1875 1 1 metabolic process cytoplasm catalytic activity;protein binding Pf00160 5480 ENSG00000168938.5 PPIC 5 0 High P13674 Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2 0.002 2.768 2 1 1 1 534 61 6.01 1 1 cell organization and biogenesis;metabolic process endoplasmic reticulum;membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf03171, Pf08336" 5033 ENSG00000122884.12 P4HA1 10 Collagen biosynthesis and modifying enzymes Metabolic pathways; Arginine and proline metabolism 0 High Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3 0.001 3.927 0 1 1 1 4374 481.6 5.22 1 1 4439796 343580.4688 62665.42188 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;protein binding;RNA binding "Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" 10075 ENSG00000086758.15 HUWE1 X Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation Ubiquitin mediated proteolysis 0 Medium O75396 Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=4 0.017 1.659 7 1 1 1 215 24.6 6.92 1 1 337223.9688 476474.1875 1 1 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding "Pf00957, Pf13774" 9554 SEC22B 1 COPI-dependent Golgi-to-ER retrograde traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; ER-Phagosome pathway Phagosome; SNARE interactions in vesicular transport; Legionellosis 0 Medium Q03164 Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5 0.013 1.79 0 1 1 1 3969 431.5 9.09 1 1 906181.625 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771, Pf13832, Pf15446" 4297 ENSG00000118058.20 KMT2A; MLL 11 PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs Lysine degradation; Transcriptional misregulation in cancer 0 High Q53S58 Transmembrane protein 177 OS=Homo sapiens OX=9606 GN=TMEM177 PE=1 SV=1 0.002 3.086 3 1 1 1 311 33.7 9.61 1 1 796135.0625 1363507.125 1 1 membrane 80775 ENSG00000144120.12 TMEM177 2 0 Medium Q4G0M1 Erythroferrone OS=Homo sapiens OX=9606 GN=ERFE PE=2 SV=2 0.025 1.524 2 1 1 1 354 37.3 9.83 1 1 259541.0625 511243.1875 1 1 cellular homeostasis;regulation of biological process extracellular protein binding 151176 ENSG00000178752.15 FAM132B; ERFE 2 0 High Q49MG5 Microtubule-associated protein 9 OS=Homo sapiens OX=9606 GN=MAP9 PE=1 SV=3 0 5.027 2 1 1 1 647 74.2 7.8 1 1 1856536 497813.9375 1 1 cell division;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding 79884 ENSG00000164114.18 MAP9 4 0 Low B0I1T2 Unconventional myosin-Ig OS=Homo sapiens OX=9606 GN=MYO1G PE=1 SV=2 0.059 1.038 2 1 1 1 1018 116.4 8.73 1 1 cellular component movement;regulation of biological process;response to stimulus;transport membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 64005 ENSG00000136286.14 MYO1G 7 0 High Q8TF09 Dynein light chain roadblock-type 2 OS=Homo sapiens OX=9606 GN=DYNLRB2 PE=1 SV=1 0.004 2.286 10 1 1 1 96 10.8 7.5 1 1 144230.7813 6711784 1 1 Met-loss+Acetyl [N-Term] cellular component movement;transport cytoplasm;cytoskeleton catalytic activity;motor activity;protein binding Pf03259 83657 ENSG00000168589.14 DYNLRB2 16 Intraflagellar transport 0 Medium Q8NAV1 Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1 0.038 1.274 4 1 1 1 312 37.5 9.96 1 1 cell organization and biogenesis;metabolic process membrane;nucleus;spliceosomal complex protein binding;RNA binding Pf03371 84950 ENSG00000134748.12 PRPF38A 1 mRNA Splicing - Major Pathway Spliceosome 0 High Q9Y4R8 Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2 0.003 2.463 1 1 1 1 837 91.7 5.76 1 1 1615036.25 376179.125 1 1 regulation of biological process chromosome;cytoplasm;cytosol;membrane;nucleus protein binding;structural molecule activity Pf10193 9894 ENSG00000100726.14 TELO2 16 Fanconi anemia pathway; mTOR signaling pathway 0 Low A1KZ92 Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=3 0.073 0.886 1 1 1 1 1463 163.6 7.43 1 1 293991.625 1 metabolic process;response to stimulus cytoplasm;extracellular antioxidant activity;catalytic activity;metal ion binding;protein binding "Pf00047, Pf00093, Pf03098, Pf05825, Pf07679, Pf12714, Pf12799, Pf13855, Pf13895, Pf13927" 137902 ENSG00000147485.12 PXDNL 8 0 High P53992 Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3 0.003 2.538 2 1 1 1 1094 118.2 7.06 1 1 1120557.5 406279.5938 156850.4844 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane metal ion binding;protein binding "Pf00626, Pf03154, Pf04503, Pf04652, Pf04810, Pf04811, Pf04815, Pf07223, Pf08033, Pf09606, Pf09770, Pf15449" 9632 ENSG00000176986.15 SEC24C 10 "Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" Protein processing in endoplasmic reticulum 0 High Q96F44 E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2 0.002 2.818 2 1 1 1 468 52.7 5.69 1 1 910123.8125 701907.25 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227" 81559 ENSG00000154370.15 TRIM11 1 Antigen processing: Ubiquitination & Proteasome degradation 0 Medium O14578 Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2 0.041 1.205 1 1 1 1 2027 231.3 6.57 1 1 117766.4063 1 cell death;cell differentiation;cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00069, Pf00130, Pf00169, Pf00433, Pf00780, Pf01496, Pf01576, Pf01636, Pf02463, Pf03962, Pf04111, Pf04156, Pf05557, Pf05622, Pf05667, Pf07714, Pf07888, Pf07926, Pf08614, Pf10174, Pf12128, Pf14531" 11113 ENSG00000122966.15 CIT 12 RHO GTPases activate CIT 0 High Q15428 Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2 0.001 4.091 4 1 1 1 464 49.2 9.64 1 1 1987239.875 1581377.75 4506754 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding Pf12874 8175 ENSG00000104897.9 SF3A2 19 mRNA Splicing - Major Pathway Spliceosome 0 High O43813 Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1 0 4.44 3 1 1 1 399 45.3 7.75 1 1 219105.0469 811282.375 1 1 regulation of biological process;response to stimulus cytoplasm;membrane metal ion binding;protein binding;receptor activity;signal transducer activity Pf05147 10314 ENSG00000115365.11 LANCL1 2 0 High Q9Y3C6 Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1 0.002 2.974 10 1 1 1 166 18.2 7.99 1 1 2399702.25 1 metabolic process spliceosomal complex catalytic activity;protein binding Pf00160 51645 ENSG00000137168.7 PPIL1 6 mRNA Splicing - Major Pathway Spliceosome 0 Medium P50416 "Carnitine O-palmitoyltransferase 1, liver isoform OS=Homo sapiens OX=9606 GN=CPT1A PE=1 SV=2" 0.034 1.349 1 1 1 1 773 88.3 8.65 1 1 3346025.75 444787.5 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity;protein binding Pf00755 1374 ENSG00000110090.12 CPT1A 11 RORA activates gene expression; Signaling by Retinoic Acid; Import of palmitoyl-CoA into the mitochondrial matrix; PPARA activates gene expression Fatty acid degradation; PPAR signaling pathway; Glucagon signaling pathway; AMPK signaling pathway; Insulin resistance; Adipocytokine signaling pathway; Fatty acid metabolism 0 High Q969E8 Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1 0.004 2.294 5 1 1 1 191 20.9 4.39 1 1 2706893.25 1 Met-loss+Acetyl [N-Term] metabolic process nucleus protein binding Pf10273 90121 ENSG00000158526.7 TSR2 X 0 Medium Q8IVF2 Protein AHNAK2 OS=Homo sapiens OX=9606 GN=AHNAK2 PE=1 SV=2 0.048 1.14 0 1 1 1 5795 616.2 5.36 1 1 1780.515137 381663.5 1 1 cell organization and biogenesis cytoplasm;cytosol;membrane;nucleus protein binding 113146 ENSG00000185567.6 AHNAK2 14 0 High P80748 Immunoglobulin lambda variable 3-21 OS=Homo sapiens OX=9606 GN=IGLV3-21 PE=1 SV=2 0.006 2.036 9 1 1 1 117 12.4 5.29 1 1 1201898.125 942401.6875 1 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane catalytic activity "Pf00047, Pf07679, Pf07686" 28796 ENSG00000211662.2 IGLV3-21 22 FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis 0 High Q9BT09 Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1 0.001 3.287 4 1 1 1 278 30.7 5.49 1 1 1394810.875 451224.8438 1 1 defense response;regulation of biological process;response to stimulus endoplasmic reticulum;organelle lumen protein binding Pf11938 10695 ENSG00000137161.16 CNPY3 6 Trafficking and processing of endosomal TLR 0 Medium Q9H1E5 Thioredoxin-related transmembrane protein 4 OS=Homo sapiens OX=9606 GN=TMX4 PE=1 SV=1 0.015 1.724 3 1 1 1 349 38.9 4.37 1 1 11485608 183424.2656 496773.0313 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity Pf00085 56255 ENSG00000125827.8 TMX4 20 0 Low Q9NS37 CREB/ATF bZIP transcription factor OS=Homo sapiens OX=9606 GN=CREBZF PE=1 SV=2 0.053 1.085 2 1 1 1 354 37.1 5.24 1 1 1571925.5 1 metabolic process;regulation of biological process;response to stimulus mitochondrion;nucleus DNA binding;protein binding 58487 ENSG00000137504.13 CREBZF 11 0 Medium O00231 26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3 0.016 1.675 3 1 1 1 422 47.4 6.48 1 1 666541.375 627128.8125 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;protein binding;structural molecule activity Pf01399 5717 ENSG00000108671.9 PSMD11 17 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 Medium P22830 "Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2" 0.011 1.863 2 1 1 1 423 47.8 8.73 1 1 477475.4688 215125.5469 1 1 metabolic process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding Pf00762 2235 ENSG00000066926.10 FECH 18 Heme biosynthesis Porphyrin and chlorophyll metabolism; Metabolic pathways 0 High O95295 SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1 0 5.386 16 1 1 1 136 14.9 9.31 1 1 Met-loss+Acetyl [N-Term] cell communication;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;vacuole protein binding Pf14712 23557 ENSG00000143553.10 SNAPIN 1 Golgi Associated Vesicle Biogenesis 0 High Q8NBJ7 Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2 0.001 3.338 3 1 1 1 301 33.8 8 1 1 metabolic process endoplasmic reticulum;organelle lumen metal ion binding Pf03781 25870 SUMF2 7 The activation of arylsulfatases; Glycosphingolipid metabolism 0 Medium P06396 Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1 0.015 1.727 2 1 1 1 782 85.6 6.28 1 1 1869716 994838.5625 653344.4375 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen metal ion binding;protein binding Pf00626 2934 ENSG00000148180.19 GSN 9 Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins; Amyloid fiber formation Viral carcinogenesis; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis 0 Medium Q96RL1 BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2 0.04 1.234 2 1 1 1 719 79.7 5.45 1 1 1837997.625 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding 51720 ENSG00000087206.16 UIMC1 5 G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs Homologous recombination 0 High Q9BYQ5 Keratin-associated protein 4-6 OS=Homo sapiens OX=9606 GN=KRTAP4-6 PE=2 SV=4 0 8.381 14 1 1 1 205 21.8 7.94 1 1 1842265.875 1 cytosol 81871 ENSG00000198090.3 KRTAP4-6 17 Keratinization 0 High Q14676 Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3 0.001 3.874 1 1 1 1 2089 226.5 5.47 1 1 1312706.5 1 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus protein binding "Pf00498, Pf05109, Pf05539" 9656 ENSG00000228575.9; ENSG00000137337.14; ENSG00000225589.9; ENSG00000224587.9; ENSG00000234012.9; ENSG00000237095.9 MDC1 6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_MCF_CTG1 G2/M DNA damage checkpoint; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins 0 High Q9NVE5 Ubiquitin carboxyl-terminal hydrolase 40 OS=Homo sapiens OX=9606 GN=USP40 PE=1 SV=3 0 4.356 2 1 1 1 1235 140 5.67 1 1 168768.8281 1 Acetyl [N-Term] metabolic process catalytic activity "Pf00443, Pf13423" 55230 ENSG00000085982.13 USP40 2 0 High Q9Y3A3 MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1 0.007 1.971 6 1 1 1 225 26 5.78 1 1 transport cytoplasm;cytosol;Golgi;membrane metal ion binding;protein binding Pf03637 25843 ENSG00000115540.14 MOB4 2 0 Medium Q96S06 Lipase maturation factor 1 OS=Homo sapiens OX=9606 GN=LMF1 PE=1 SV=1 0.035 1.32 1 1 1 1 567 64.8 9.31 1 1 372417.875 1 metabolic process;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane Pf06762 64788 ENSG00000103227.18 LMF1 16 Assembly of active LPL and LIPC lipase complexes 0 High Q6ZYL4 General transcription factor IIH subunit 5 OS=Homo sapiens OX=9606 GN=GTF2H5 PE=1 SV=1 0.004 2.434 15 1 1 1 71 8 4.65 1 1 3284232 2887448 2366814.25 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding Pf06331 404672 ENSG00000272047.1 GTF2H5 6 Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; RNA Polymerase I Promoter Escape; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; Formation of Incision Complex in GG-NER; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Dual incision in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex Basal transcription factors; Nucleotide excision repair 0 Medium Q9HAT2 Sialate O-acetylesterase OS=Homo sapiens OX=9606 GN=SIAE PE=1 SV=1 0.045 1.179 2 1 1 1 523 58.3 7.33 1 1 metabolic process;regulation of biological process extracellular;vacuole catalytic activity Pf03629 54414 ENSG00000110013.12 SIAE 11 0 Medium Q8TDB4 Protein MGARP OS=Homo sapiens OX=9606 GN=MGARP PE=1 SV=1 0.021 1.575 13 1 1 1 240 25.4 4.44 1 1 cellular component movement;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding Pf14962 84709 ENSG00000137463.4 MGARP 4 0 Medium P56159 GDNF family receptor alpha-1 OS=Homo sapiens OX=9606 GN=GFRA1 PE=2 SV=2 0.048 1.13 1 1 1 1 465 51.4 7.91 1 1 229714.0313 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus membrane protein binding;receptor activity;signal transducer activity Pf02351 2674 ENSG00000151892.14 GFRA1 10 RET signaling; NCAM1 interactions; RAF/MAP kinase cascade; Interleukin-20 family signaling 0 High Q9Y305 "Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2" 0.001 3.526 2 1 1 1 439 49.9 8.6 1 1 2296832.25 1 metabolic process mitochondrion;organelle lumen catalytic activity Pf03061 23597 ENSG00000123130.16 ACOT9 X Mitochondrial Fatty Acid Beta-Oxidation 0 High O95754 Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=2 0.001 3.256 2 1 1 1 770 83.5 6.95 1 1 354170 1 cell communication;cell differentiation;cellular component movement;development;regulation of biological process;response to stimulus endoplasmic reticulum;membrane protein binding "Pf01403, Pf01437" 10505 ENSG00000135622.12 SEMA4F 2 Axon guidance 0 High Q99943 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens OX=9606 GN=AGPAT1 PE=1 SV=2 0 4.784 7 1 1 1 283 31.7 9.38 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;protein binding Pf01553 10554 ENSG00000235758.9; ENSG00000228892.9; ENSG00000227642.9; ENSG00000206324.11; ENSG00000204310.12; ENSG00000236873.9; ENSG00000226467.9 AGPAT1 6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_COX_CTG1 Synthesis of PA; ChREBP activates metabolic gene expression Fat digestion and absorption; Phospholipase D signaling pathway; Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways 0 High Q9Y2D9 Zinc finger protein 652 OS=Homo sapiens OX=9606 GN=ZNF652 PE=1 SV=3 0.003 2.671 2 1 1 1 606 69.7 8.65 1 1 3074349.5 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf13465" 22834 ENSG00000198740.8 ZNF652 17 0 Medium Q13459 Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3 0.015 1.748 0 1 1 1 2157 243.2 8.75 1 1 1663654.125 1 cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;enzyme regulator activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00063, Pf00130, Pf00612, Pf00620, Pf00788, Pf06070" 4650 MYO9B 19 SLIT2:ROBO1 increases RHOA activity; Regulation of actin dynamics for phagocytic cup formation; Rho GTPase cycle 0 Medium Q6P996 Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2 0.025 1.53 1 1 1 1 788 86.7 5.38 1 1 1729308.875 169504.4375 93911.625 1 1 1 metabolic process Golgi catalytic activity;protein binding "Pf00282, Pf01212" 23042; 102724985 ENSG00000275498.5; ENSG00000179889.18 PDXDC1; LOC102724985 16; CHR_HSCHR16_1_CTG1 0 High Q96HE7 ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2 0.001 3.755 3 1 1 1 468 54.4 5.68 1 1 cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding Pf04137 30001 ENSG00000197930.12 ERO1L; ERO1A 14 Insulin processing; Detoxification of Reactive Oxygen Species Protein processing in endoplasmic reticulum; Vibrio cholerae infection 0 High Q6ZSZ5 Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4 0.005 2.116 1 1 1 1 1361 151.5 6.33 1 1 785795 1 0 High Q8TCC3 "39S ribosomal protein L30, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1" 0.004 2.347 6 1 1 1 161 18.5 9.99 1 1 904203.875 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf00327 51263 ENSG00000185414.19 MRPL30 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 Medium Q96JM7 Lethal(3)malignant brain tumor-like protein 3 OS=Homo sapiens OX=9606 GN=L3MBTL3 PE=1 SV=2 0.048 1.134 1 1 1 1 780 88.3 6.46 1 1 909169.8125 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process nucleus metal ion binding;protein binding "Pf00536, Pf01530, Pf02820, Pf07647" 84456 ENSG00000198945.7 L3MBTL3 6 0 High Q96BN2 Transcriptional adapter 1 OS=Homo sapiens OX=9606 GN=TADA1 PE=1 SV=1 0.001 3.832 4 1 1 1 335 37.4 7.39 1 1 264041 1042186.063 277841.7813 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytosol;nucleus catalytic activity Pf12767 117143 ENSG00000152382.5 TADA1 1 HATs acetylate histones 0 Low Q96AY2 Crossover junction endonuclease EME1 OS=Homo sapiens OX=9606 GN=EME1 PE=1 SV=2 0.061 1.019 1 1 1 1 570 63.2 7.05 1 1 47643.36328 1684143.125 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding 146956 ENSG00000154920.14 EME1 17 Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Fanconi anemia pathway 0 Medium Q86UN3 Reticulon-4 receptor-like 2 OS=Homo sapiens OX=9606 GN=RTN4RL2 PE=1 SV=1 0.026 1.504 3 1 1 1 420 46.1 7.62 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;extracellular;membrane enzyme regulator activity;protein binding;receptor activity "Pf12799, Pf13306, Pf13855" 349667 ENSG00000186907.7 RTN4RL2 11 Post-translational modification: synthesis of GPI-anchored proteins 0 High O75925 E3 SUMO-protein ligase PIAS1 OS=Homo sapiens OX=9606 GN=PIAS1 PE=1 SV=2 0.001 4.223 2 1 1 1 651 71.8 7.3 1 1 792261.5625 491545.9375 526053.375 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf02891, Pf14324" 8554 ENSG00000033800.13 PIAS1 15 SUMOylation of chromatin organization proteins; Formation of Incision Complex in GG-NER; Regulation of IFNG signaling; SUMOylation of transcription factors; SUMOylation of DNA damage response and repair proteins Ubiquitin mediated proteolysis; Jak-STAT signaling pathway; Hepatitis C 0 High P17098 Zinc finger protein 8 OS=Homo sapiens OX=9606 GN=ZNF8 PE=1 SV=2 0.005 2.113 2 1 1 1 575 64.9 7.39 1 1 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 7554 ENSG00000278129.1 ZNF8 19 0 Medium O43865 S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2 0.013 1.799 2 1 1 1 530 58.9 6.89 1 1 444261.2188 597153.1875 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00670, Pf01262, Pf01488, Pf02254, Pf02826, Pf05221" 10768 ENSG00000168710.17 AHCYL1 1 Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; DAG and IP3 signaling; Signaling by GPCR; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis Metabolic pathways; Cysteine and methionine metabolism 0 High O95363 "Phenylalanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=FARS2 PE=1 SV=1" 0.003 2.542 3 1 1 1 451 52.3 7.46 1 1 metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf01409, Pf03147" 10667 ENSG00000145982.11 FARS2 6 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 Medium O75586 Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2 0.027 1.487 4 1 1 1 246 28.4 8.62 1 1 390579.8125 1 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus protein binding Pf04934 10001 ENSG00000133997.11 MED6 14 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 High Q9Y3A2 Probable U3 small nucleolar RNA-associated protein 11 OS=Homo sapiens OX=9606 GN=UTP11 PE=1 SV=2 0 9.651 8 1 1 1 253 30.4 10.15 1 1 metabolic process;regulation of biological process cytoplasm;nucleus protein binding;RNA binding Pf03998 51118 ENSG00000183520.11 UTP11L; UTP11 1 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q9H813 Transmembrane protein 206 OS=Homo sapiens OX=9606 GN=TMEM206 PE=1 SV=1 0.002 2.846 3 1 1 1 350 40 8.88 1 1 3397827.75 622182.1875 1 1 cell surface;membrane Pf15122 55248 ENSG00000065600.12 TMEM206 1 0 High P34932 Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4 0.002 2.965 2 1 1 1 840 94.3 5.19 1 1 2383932 490861 1 1 cell organization and biogenesis;response to stimulus;transport cytoplasm;cytosol nucleotide binding;protein binding "Pf00012, Pf06723" 3308 ENSG00000170606.14 HSPA4 5 Regulation of HSF1-mediated heat shock response Antigen processing and presentation 0 High Q9P0J0 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Homo sapiens OX=9606 GN=NDUFA13 PE=1 SV=3 0.001 3.125 10 1 1 1 144 16.7 8.43 1 1 656876.875 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding Pf06212 51079 ENSG00000186010.18 NDUFA13 19 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High P41002 Cyclin-F OS=Homo sapiens OX=9606 GN=CCNF PE=1 SV=2 0.001 3.237 2 1 1 1 786 87.6 6.33 1 1 570233.4375 1 cell division;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;protein binding "Pf00134, Pf00646, Pf02984, Pf12937" 899 ENSG00000162063.12 CCNF 16 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 Medium O14672 Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ADAM10 PE=1 SV=1 0.023 1.556 1 1 1 1 748 84.1 7.77 1 1 2604162.25 752096.6875 282948.5938 1 1 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;Golgi;membrane;nucleus;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00200, Pf01421, Pf01562, Pf12785, Pf13574, Pf13582, Pf13583, Pf13688" 102 ENSG00000137845.14 ADAM10 15 Collagen degradation; Post-translational protein phosphorylation; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by NOTCH4; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Signaling by NOTCH3; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Signaling by EGFR Alzheimer's disease; Epithelial cell signaling in Helicobacter pylori infection 0 High P27544 Ceramide synthase 1 OS=Homo sapiens OX=9606 GN=CERS1 PE=1 SV=1 0.007 2.002 3 1 1 1 350 39.5 9.04 1 1 2580432.75 405974 771149.8125 1 1 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity Pf03798 10715 ENSG00000223802.7 CERS1 19 Sphingolipid de novo biosynthesis Sphingolipid metabolism; Sphingolipid signaling pathway; Metabolic pathways 0 High P20036 "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" 0 4.538 5 1 1 1 260 29.4 5.21 1 1 1819682.875 1 regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;endosome;Golgi;membrane;vacuole receptor activity;signal transducer activity "Pf00993, Pf07654" 3113 ENSG00000231389.7; ENSG00000235844.8; ENSG00000229685.8; ENSG00000224103.7; ENSG00000236177.9; ENSG00000168384.11; ENSG00000206291.10; ENSG00000228163.8 HLA-DPA1 6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1 PD-1 signaling; Translocation of ZAP-70 to Immunological synapse; MHC class II antigen presentation; Downstream TCR signaling; Generation of second messenger molecules; Interferon gamma signaling; Phosphorylation of CD3 and TCR zeta chains Th1 and Th2 cell differentiation; Inflammatory bowel disease (IBD); Asthma; Hematopoietic cell lineage; Allograft rejection; Epstein-Barr virus infection; Leishmaniasis; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Tuberculosis; HTLV-I infection; Toxoplasmosis; Phagosome; Autoimmune thyroid disease; Systemic lupus erythematosus; Herpes simplex infection; Viral myocarditis; Staphylococcus aureus infection; Graft-versus-host disease; Influenza A; Intestinal immune network for IgA production; Antigen processing and presentation; Rheumatoid arthritis 0 Medium Q13510 Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5 0.048 1.135 2 1 1 1 395 44.6 7.62 1 1 794661.1875 1 metabolic process;transport extracellular;organelle lumen;vacuole catalytic activity "Pf02275, Pf15508" 427 ENSG00000104763.18 ASAH1 8 Glycosphingolipid metabolism; Neutrophil degranulation Lysosome; Sphingolipid metabolism; Sphingolipid signaling pathway; Metabolic pathways 0 High Q07864 DNA polymerase epsilon catalytic subunit A OS=Homo sapiens OX=9606 GN=POLE PE=1 SV=5 0.001 4.023 1 1 1 1 2286 261.4 6.39 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00136, Pf03104, Pf08490, Pf10108, Pf13482" 5426 ENSG00000177084.16 POLE 12 Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Activation of the pre-replicative complex; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; M/G1 Transition; Termination of translesion DNA synthesis; Recognition of DNA damage by PCNA-containing replication complex; DNA replication initiation; Dual incision in TC-NER; Telomere C-strand synthesis initiation; PCNA-Dependent Long Patch Base Excision Repair DNA replication; Purine metabolism; Base excision repair; HTLV-I infection; Nucleotide excision repair; Metabolic pathways; Pyrimidine metabolism 0 Medium Q14566 DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1 0.035 1.34 1 1 1 1 821 92.8 5.41 1 1 metabolic process nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf01078, Pf07728, Pf14551" 4175 ENSG00000076003.4 MCM6 2 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High Q8IZP0 Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4 0 4.67 3 1 1 1 508 55 7.06 1 1 1284977.125 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus enzyme regulator activity;protein binding "Pf00018, Pf07653, Pf07815, Pf14604" 10006 ENSG00000136754.16 ABI1 10 Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs 0 High P62310 U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2 0.004 2.407 12 1 1 1 102 11.8 4.7 1 1 61164.45703 2203960 1 1 cell organization and biogenesis;metabolic process cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 27258 ENSG00000170860.3 LSM3 3 mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease Spliceosome; RNA degradation 0 High O00767 Acyl-CoA desaturase OS=Homo sapiens OX=9606 GN=SCD PE=1 SV=2 0.001 3.654 4 1 1 1 359 41.5 9 1 1 2651332.25 992812.875 1541608.75 1 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf00487 6319 ENSG00000099194.5 SCD 10 Fatty acyl-CoA biosynthesis; Activation of gene expression by SREBF (SREBP) PPAR signaling pathway; AMPK signaling pathway; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism 0 High Q96EX3 WD repeat-containing protein 34 OS=Homo sapiens OX=9606 GN=WDR34 PE=1 SV=2 0 7.325 3 1 1 1 536 57.8 6.64 1 1 cell organization and biogenesis;cellular component movement;transport cytoplasm;cytoskeleton;cytosol catalytic activity;motor activity;protein binding Pf00400 89891 ENSG00000119333.11 WDR34 9 Intraflagellar transport 0 High O95801 Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3 0.001 3.902 3 1 1 1 387 44.7 5.6 1 1 615364.4375 635381.9375 1 1 protein binding "Pf13414, Pf13432" 7268 ENSG00000243725.6 TTC4 1 0 High Q96DP5 "Methionyl-tRNA formyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=MTFMT PE=1 SV=2" 0 4.794 4 1 1 1 389 43.8 9.66 1 1 338222.9688 2353135 1 1 metabolic process mitochondrion catalytic activity "Pf00551, Pf02911" 123263 ENSG00000103707.9 MTFMT 15 Mitochondrial translation initiation Aminoacyl-tRNA biosynthesis; One carbon pool by folate 0 High O00522 Krev interaction trapped protein 1 OS=Homo sapiens OX=9606 GN=KRIT1 PE=1 SV=2 0.009 1.875 2 1 1 1 736 84.3 8.41 1 1 cellular homeostasis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane enzyme regulator activity;protein binding "Pf00023, Pf00373, Pf12796, Pf13637, Pf13857" 889 ENSG00000001631.15 KRIT1 7 Rap1 signaling pathway 0 High O14874 "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2" 0 5.305 5 1 1 1 412 46.3 8.82 1 1 1127692.25 502037.4375 341354.375 1 1 1 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf02518, Pf10436" 10295 ENSG00000103507.13 BCKDK 16 Branched-chain amino acid catabolism 0 High O15084 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5 0.004 2.379 2 1 1 1 1053 112.9 6.25 1 1 418624.0938 355779.0938 1 1 cell organization and biogenesis cytosol;membrane;nucleus protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 23243 ENSG00000206560.11 ANKRD28 3 COPII (Coat Protein 2) Mediated Vesicle Transport 0 Medium Q7Z4W1 L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2 0.025 1.522 3 1 1 1 244 25.9 8.1 1 1 334838.5938 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process membrane;nucleus catalytic activity;protein binding "Pf00106, Pf01488, Pf08659, Pf13460, Pf13561" 51181 ENSG00000169738.7 DCXR 17 Catabolism of glucuronate to xylulose-5-phosphate; Essential pentosuria Pentose and glucuronate interconversions; Metabolic pathways 0 Medium Q9Y2L1 Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2 0.012 1.821 1 1 1 1 958 108.9 7.14 1 1 513032.2188 253140.6563 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00773, Pf09742, Pf13638" 22894 ENSG00000083520.14 DIS3 13 "Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA" RNA degradation 0 High O75787 Renin receptor OS=Homo sapiens OX=9606 GN=ATP6AP2 PE=1 SV=2 0.004 2.433 2 1 1 1 350 39 6.1 1 1 788852.5625 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane protein binding;receptor activity;transporter activity Pf07850 10159 ENSG00000182220.14 ATP6AP2 X Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation Renin-angiotensin system 0 Medium Q8NBN3 Transmembrane protein 87A OS=Homo sapiens OX=9606 GN=TMEM87A PE=1 SV=3 0.04 1.229 2 1 1 1 555 63.4 6.74 1 1 440729.8438 1 transport cytosol;Golgi;membrane Pf06814 25963 ENSG00000103978.15 TMEM87A 15 0 Low Q96N66 Lysophospholipid acyltransferase 7 OS=Homo sapiens OX=9606 GN=MBOAT7 PE=1 SV=2 0.054 1.065 3 1 1 1 472 52.7 8.97 1 1 metabolic process membrane catalytic activity;protein binding Pf03062 79143 ENSG00000278519.4; ENSG00000277025.4; ENSG00000277923.4; ENSG00000277733.4; ENSG00000274194.4; ENSG00000273592.4; ENSG00000276935.4; ENSG00000278322.4; ENSG00000125505.16; ENSG00000275118.4 MBOAT7 19; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1 Acyl chain remodelling of PI Glycerophospholipid metabolism 0 Low Q6ZT98 Tubulin polyglutamylase TTLL7 OS=Homo sapiens OX=9606 GN=TTLL7 PE=1 SV=2 0.056 1.057 1 1 1 1 887 102.9 9.29 1 1 3729656.75 3311115.75 1 1 cell differentiation;development;metabolic process cytoplasm;cytoskeleton;cytosol catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf02655, Pf03133, Pf13535" 79739 ENSG00000137941.16 TTLL7 1 Carboxyterminal post-translational modifications of tubulin 0 High Q99741 Cell division control protein 6 homolog OS=Homo sapiens OX=9606 GN=CDC6 PE=1 SV=1 0 6.349 3 1 1 1 560 62.7 9.58 1 1 cell division;metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;nucleus metal ion binding;nucleotide binding;protein binding "Pf00004, Pf09079, Pf13191, Pf13401" 990 ENSG00000094804.9 CDC6 17 CDT1 association with the CDC6:ORC:origin complex; Regulation of DNA replication; Activation of the pre-replicative complex; Association of licensing factors with the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; Orc1 removal from chromatin; M/G1 Transition; Activation of ATR in response to replication stress; Activation of E2F1 target genes at G1/S; CDC6 association with the ORC:origin complex; Transcription of E2F targets under negative control by DREAM complex; Removal of licensing factors from origins Cell cycle 0 High Q15043 Zinc transporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3 0.001 3.646 2 1 1 1 492 54.2 5.33 1 1 516185.6563 700621.75 1 1 cellular homeostasis;transport cytoplasm;membrane transporter activity Pf02535 23516 ENSG00000104635.13 SLC39A14 8 Zinc influx into cells by the SLC39 gene family 0 High Q13613 Myotubularin-related protein 1 OS=Homo sapiens OX=9606 GN=MTMR1 PE=1 SV=4 0.001 3.558 1 1 1 1 665 74.6 7.14 1 1 787952.8125 1 metabolic process cytoplasm;cytosol;membrane catalytic activity;protein binding "Pf02893, Pf06602" 8776 ENSG00000063601.16 MTMR1 X Synthesis of PIPs at the plasma membrane Phosphatidylinositol signaling system; Inositol phosphate metabolism; Metabolic pathways 0 High Q92624 Amyloid protein-binding protein 2 OS=Homo sapiens OX=9606 GN=APPBP2 PE=1 SV=2 0.008 1.93 3 1 1 1 585 66.8 6.9 1 1 5130720.5 245937.6563 762657.75 1 1 1 transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding "Pf13374, Pf13424" 10513 ENSG00000062725.9 APPBP2 17 0 Medium Q96ST3 Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2 0.04 1.227 1 1 1 1 1273 145.1 7.25 1 1 164699.2344 9681089 1 1 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf02671, Pf08295" 25942 ENSG00000169375.15 SIN3A 15 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha); NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production Huntington's disease; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer 0 Medium Q9P2N7 Kelch-like protein 13 OS=Homo sapiens OX=9606 GN=KLHL13 PE=1 SV=3 0.026 1.492 1 1 1 1 655 73.8 6.62 1 1 133444.4531 1 cell division;metabolic process cytosol catalytic activity;protein binding "Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13854, Pf13964" 90293 ENSG00000003096.14 KLHL13 X Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 High Q9UNS2 COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3 0.002 2.833 3 1 1 1 423 47.8 6.65 1 1 2549278.25 224623.5781 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding Pf01399 8533 ENSG00000141030.12 COPS3 17 Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation 0 High Q8TES7 Fas-binding factor 1 OS=Homo sapiens OX=9606 GN=FBF1 PE=1 SV=2 0.006 2.058 1 1 1 1 1133 125.4 7.08 1 1 1018520.625 2679422.25 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol catalytic activity;motor activity;protein binding "Pf00769, Pf01576, Pf02463, Pf04111, Pf10186, Pf12128, Pf13868, Pf14988, Pf15558" 85302 ENSG00000188878.19 FBF1 17 Anchoring of the basal body to the plasma membrane 0 High O14681 Etoposide-induced protein 2.4 homolog OS=Homo sapiens OX=9606 GN=EI24 PE=1 SV=4 0.003 2.601 2 1 1 1 340 38.9 9.72 1 1 9341811 1164890.5 1 1 cell communication;cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus Pf07264 9538 ENSG00000149547.14 EI24 11 p53 signaling pathway 0 Medium Q5VU97 VWFA and cache domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CACHD1 PE=2 SV=2 0.016 1.683 1 1 1 1 1274 142.2 6.43 1 1 510090.7188 610150.25 422265.2188 1 1 1 transport membrane "Pf02743, Pf08399" 57685 CACHD1 1 0 High Q8ND90 Paraneoplastic antigen Ma1 OS=Homo sapiens OX=9606 GN=PNMA1 PE=1 SV=2 0.001 4.269 3 1 1 1 353 39.7 4.83 1 1 981604.25 1 Met-loss+Acetyl [N-Term] defense response;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding Pf14893 9240 ENSG00000176903.4 PNMA1 14 0 Medium O94806 Serine/threonine-protein kinase D3 OS=Homo sapiens OX=9606 GN=PRKD3 PE=1 SV=1 0.034 1.354 1 1 1 1 890 100.4 6.87 1 1 126724.8203 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf00130, Pf00169, Pf07714, Pf14531" 23683 ENSG00000115825.9 PRKD3 2 Sphingolipid de novo biosynthesis Rap1 signaling pathway; Aldosterone synthesis and secretion 0 Low P10586 Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=2 0.073 0.882 1 1 1 1 1907 212.7 6.3 1 1 493635.0313 3182599.5 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;protein binding;receptor activity;signal transducer activity "Pf00041, Pf00047, Pf00102, Pf07679, Pf13895, Pf13927, Pf14566" 5792 ENSG00000142949.16 PTPRF 1 Receptor-type tyrosine-protein phosphatases; Synaptic adhesion-like molecules Insulin signaling pathway; Cell adhesion molecules (CAMs); Adherens junction; Insulin resistance 0 Medium Q9P2K2 Thioredoxin domain-containing protein 16 OS=Homo sapiens OX=9606 GN=TXNDC16 PE=1 SV=4 0.022 1.568 1 1 1 1 825 93.5 5.21 1 1 192036.2969 482172.8438 1 1 cellular homeostasis;regulation of biological process endoplasmic reticulum;extracellular;organelle lumen protein binding "Pf00085, Pf13848" 57544 ENSG00000087301.8 TXNDC16 14 0 Medium Q8N573 Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2 0.025 1.533 2 1 1 1 874 97.9 5.47 1 1 7164087.5 1 cell death;metabolic process;regulation of biological process;response to stimulus mitochondrion catalytic activity;protein binding "Pf01476, Pf07534" 55074 ENSG00000164830.18 OXR1 8 0 High Q86SX3 Tubulin epsilon and delta complex protein 1 OS=Homo sapiens OX=9606 GN=TEDC1 PE=1 SV=2 0.001 3.162 2 1 1 1 495 54.2 8.05 1 1 protein binding "Pf14970, Pf14971" 283643 ENSG00000185347.17 C14orf80; TEDC1 14 0 High Q9P2C4 Transmembrane protein 181 OS=Homo sapiens OX=9606 GN=TMEM181 PE=1 SV=2 0 5.511 3 1 1 1 612 69.3 8.92 1 1 1791619.5 1613611 1 1 membrane Pf06664 57583 ENSG00000146433.8 TMEM181 6 0 High O75817 Ribonuclease P protein subunit p20 OS=Homo sapiens OX=9606 GN=POP7 PE=1 SV=2 0 9.173 14 1 1 1 140 15.6 8.94 1 1 3467237.5 1 metabolic process cytoplasm;nucleus catalytic activity;protein binding;RNA binding "Pf01918, Pf12328" 10248 ENSG00000172336.4 POP7 7 tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 Medium P48740 Mannan-binding lectin serine protease 1 OS=Homo sapiens OX=9606 GN=MASP1 PE=1 SV=3 0.025 1.519 2 1 1 1 699 79.2 5.49 1 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular catalytic activity;metal ion binding;protein binding "Pf00084, Pf00089, Pf00431, Pf07645, Pf12662, Pf14670" 5648 ENSG00000127241.16 MASP1 3 Ficolins bind to repetitive carbohydrate structures on the target cell surface; Scavenging by Class A Receptors Complement and coagulation cascades; Staphylococcus aureus infection 0 High Q9HAK2 Transcription factor COE2 OS=Homo sapiens OX=9606 GN=EBF2 PE=2 SV=4 0.007 1.999 3 1 1 1 575 62.6 9.06 1 1 709022.875 5562238 1 1 cell differentiation;development;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding Pf01833 64641 ENSG00000221818.8 EBF2 8 0 Medium Q7L5Y9 E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1 0.017 1.652 2 1 1 1 396 45.3 8.69 1 1 435006.2813 248028.3438 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;protein binding Pf10607 10296 ENSG00000090316.15 MAEA 4 0 High P09622 "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" 0.001 3.335 2 1 1 1 509 54.1 7.85 1 1 691195.5 237244.2656 1 1 cellular homeostasis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00070, Pf00890, Pf01134, Pf02852, Pf03486, Pf07992, Pf12831, Pf13450" 1738 ENSG00000091140.13 DLD 7 Glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Lysine catabolism; Signaling by Retinoic Acid; Branched-chain amino acid catabolism; Citric acid cycle (TCA cycle) "Propanoate metabolism; Citrate cycle (TCA cycle); Carbon metabolism; Glycine, serine and threonine metabolism; Pyruvate metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Valine, leucine and isoleucine degradation" 0 Medium Q9P013 Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2 0.048 1.13 6 1 1 1 229 26.6 5.71 1 1 1411502 1 Met-loss+Acetyl [N-Term] metabolic process mitochondrion;nucleus;spliceosomal complex protein binding;RNA binding Pf04889 51503 ENSG00000150316.11 CWC15 11 mRNA Splicing - Major Pathway Spliceosome 0 High P26639 "Threonine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS PE=1 SV=3" 0.001 3.712 2 1 1 1 723 83.4 6.67 1 1 803347.8125 1 metabolic process cytoplasm;cytoskeleton;cytosol catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00587, Pf02824, Pf03129, Pf07973" 6897 ENSG00000113407.13 TARS 5 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q96F46 Interleukin-17 receptor A OS=Homo sapiens OX=9606 GN=IL17RA PE=1 SV=2 0.002 2.861 1 1 1 1 866 96.1 5.21 1 1 103433.0703 315141.1563 1 1 cellular component movement;defense response;regulation of biological process;response to stimulus extracellular;membrane protein binding;receptor activity;signal transducer activity Pf08357 23765 ENSG00000177663.13 IL17RA 22 Interleukin-17 signaling Cytokine-cytokine receptor interaction 0 High Q8NCR0 "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=B3GALNT2 PE=1 SV=1" 0.003 2.757 3 1 1 1 500 56.7 5.71 1 1 708532.1875 691265.3125 1 1 metabolic process endoplasmic reticulum;Golgi;membrane catalytic activity Pf01762 148789 ENSG00000282880.1; ENSG00000162885.12 B3GALNT2 1; CHR_HSCHR1_5_CTG32_1 O-linked glycosylation 0 High Q9UPT8 Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3 0.009 1.872 2 1 1 1 1303 140.2 6.27 1 1 metal ion binding;RNA binding Pf00642 23211 ENSG00000130749.9 ZC3H4 19 0 Medium O14802 DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2 0.022 1.589 1 1 1 1 1390 155.5 8.48 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" 11128 ENSG00000148606.12 POLR3A 10 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 Medium Q8IYT3 Coiled-coil domain-containing protein 170 OS=Homo sapiens OX=9606 GN=CCDC170 PE=1 SV=3 0.048 1.124 1 1 1 1 715 82.2 6.64 1 1 protein binding 80129 ENSG00000120262.9 CCDC170 6 0 High Q8N983 "39S ribosomal protein L43, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" 0.001 3.511 5 1 1 1 215 23.4 8.65 1 1 901133.9375 4348288.5 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf05047 84545 ENSG00000055950.16 MRPL43 10 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 Medium Q8TB96 T-cell immunomodulatory protein OS=Homo sapiens OX=9606 GN=ITFG1 PE=1 SV=1 0.015 1.722 1 1 1 1 612 68.1 5.39 1 1 extracellular;membrane Pf13517 81533 ENSG00000129636.12 ITFG1 16 0 Medium Q8NHP8 Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2 0.034 1.345 1 1 1 1 589 65.4 6.8 1 1 913186 1 metabolic process organelle lumen;vacuole catalytic activity Pf04916 196463 ENSG00000151176.7 PLBD2 12 0 High Q96EH3 Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1 0 7.695 15 1 1 1 234 26.2 5.49 1 1 512515.875 9284.026367 1 1 regulation of biological process cytosol;mitochondrion;organelle lumen protein binding Pf02410 115416 ENSG00000156928.4 MALSU1 7 0 High O00116 "Alkyldihydroxyacetonephosphate synthase, peroxisomal OS=Homo sapiens OX=9606 GN=AGPS PE=1 SV=1" 0.007 2.018 3 1 1 1 658 72.9 7.34 1 1 205407.7031 1429326.375 2376964 570791.875 1 1 1 1 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf01565, Pf02913" 8540 ENSG00000018510.13 AGPS 2 Plasmalogen biosynthesis Peroxisome; Ether lipid metabolism; Metabolic pathways 0 Medium Q96ES7 SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1 0.011 1.833 3 1 1 1 293 33.2 8.1 1 1 1430472.25 1133635.875 147424.2031 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process nucleus protein binding Pf07039 112869 ENSG00000176476.8 CCDC101; SGF29 16 HATs acetylate histones 0 Medium P11388 DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3 0.015 1.698 0 1 1 1 1531 174.3 8.72 1 1 3364589 1 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070" 7153 ENSG00000131747.14 TOP2A 17 SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex Platinum drug resistance 0 High Q9H7Z3 Protein NRDE2 homolog OS=Homo sapiens OX=9606 GN=NRDE2 PE=1 SV=3 0 5.563 2 1 1 1 1164 132.6 7.68 1 1 1087260.625 582677.9375 1 1 Met-loss+Acetyl [N-Term] regulation of biological process spliceosomal complex protein binding Pf08424 55051 ENSG00000119720.17 NRDE2 14 0 Medium Q01955 Collagen alpha-3(IV) chain OS=Homo sapiens OX=9606 GN=COL4A3 PE=1 SV=3 0.035 1.326 1 1 1 1 1670 161.7 9.16 1 1 6779108.5 9381227 1 1 cell death;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular;organelle lumen enzyme regulator activity;protein binding;structural molecule activity "Pf01391, Pf01413" 1285 ENSG00000169031.18 COL4A3 2 ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Laminin interactions; Collagen chain trimerization; Crosslinking of collagen fibrils; Anchoring fibril formation; NCAM1 interactions; Signaling by PDGF; Non-integrin membrane-ECM interactions Amoebiasis; Protein digestion and absorption; Pathways in cancer; AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High A0FGR8 Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 0.003 2.543 1 1 1 1 921 102.3 9.26 1 1 1533677.75 1 metabolic process;transport endoplasmic reticulum;membrane metal ion binding;protein binding Pf00168 57488 ESYT2 7 Glycosphingolipid metabolism 0 High Q9P003 Protein cornichon homolog 4 OS=Homo sapiens OX=9606 GN=CNIH4 PE=1 SV=1 0 5.918 14 1 1 1 139 16.1 6.65 1 1 649036.75 661555.6875 2136704.25 1 1 1 transport endoplasmic reticulum;membrane protein binding Pf03311 29097 ENSG00000143771.11 CNIH4 1 0 High Q96L58 "Beta-1,3-galactosyltransferase 6 OS=Homo sapiens OX=9606 GN=B3GALT6 PE=1 SV=2" 0 5.016 4 1 1 1 329 37.1 9.66 1 1 metabolic process Golgi;membrane catalytic activity Pf01762 126792 ENSG00000176022.4 B3GALT6 1 Defective B3GALT6 causes EDSP2 and SEMDJL1; A tetrasaccharide linker sequence is required for GAG synthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 Medium Q9HB71 Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2 0.013 1.818 3 1 1 1 228 26.2 8.25 1 1 254965.5469 448645.7188 323985.1563 1 1 1 cell differentiation;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding "Pf04969, Pf05002, Pf09032" 27101 ENSG00000116161.17 CACYBP 1 Wnt signaling pathway 0 High Q6PCT2 F-box/LRR-repeat protein 19 OS=Homo sapiens OX=9606 GN=FBXL19 PE=1 SV=3 0.003 2.597 1 1 1 1 694 75.7 9.17 1 1 526382.875 212318.1719 1 1 metabolic process cytosol catalytic activity;DNA binding;metal ion binding;protein binding "Pf00646, Pf02008, Pf12937" 54620 ENSG00000099364.16 FBXL19 16 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 Medium P11717 Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3 0.015 1.76 0 1 1 1 2491 274.2 5.94 1 1 377411.5625 654869.75 446488.0938 386552.1875 1 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endosome;Golgi;membrane;nucleus;vacuole catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity "Pf00040, Pf00878, Pf02157, Pf09451" 3482 ENSG00000197081.12 IGF2R 6 Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis Lysosome; Endocytosis 0 High P60900 Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1 0.003 2.59 4 1 1 1 246 27.4 6.76 1 1 766611.1875 400372.5938 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00227, Pf10584" 5687 ENSG00000100902.10 PSMA6 14 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 Medium P42331 Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2 0.038 1.285 1 1 1 1 645 73.4 6.37 1 1 8759829 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol enzyme regulator activity "Pf00169, Pf00620, Pf04111, Pf15409, Pf15413" 9938 ARHGAP25 2 Rho GTPase cycle 0 High Q9HAU0 Pleckstrin homology domain-containing family A member 5 OS=Homo sapiens OX=9606 GN=PLEKHA5 PE=1 SV=1 0 6.468 1 1 1 1 1116 127.4 7.53 1 1 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane protein binding "Pf00169, Pf00397, Pf04111, Pf15413" 54477 ENSG00000052126.14 PLEKHA5 12 Synthesis of PIPs at the plasma membrane 0 Medium Q7Z5Y7 BTB/POZ domain-containing protein KCTD20 OS=Homo sapiens OX=9606 GN=KCTD20 PE=1 SV=1 0.037 1.29 2 1 1 1 419 47.5 5.33 1 1 274706.8438 1 cell organization and biogenesis;regulation of biological process cytoplasm protein binding Pf02214 222658 ENSG00000112078.13 KCTD20 6 0 Medium Q9BU64 Centromere protein O OS=Homo sapiens OX=9606 GN=CENPO PE=1 SV=1 0.025 1.525 2 1 1 1 300 33.8 7.71 1 1 1128008.75 717900.625 1 1 cell organization and biogenesis chromosome;cytosol;nucleus protein binding Pf09496 79172 ENSG00000138092.10 CENPO 2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Deposition of new CENPA-containing nucleosomes at the centromere 0 High O43815 Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4 0.001 3.321 2 1 1 1 780 86.1 5.27 1 1 2473045.25 647418.3125 322916.1875 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;membrane protein binding "Pf00400, Pf08232" 6801 ENSG00000115808.11 STRN 2 0 High P61026 Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1 0 4.426 6 1 1 1 200 22.5 8.38 1 1 1837589.125 1285717 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf04670, Pf08477" 10890 ENSG00000084733.10 RAB10 2 Translocation of GLUT4 to the plasma membrane; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation Endocytosis; AMPK signaling pathway 0 Medium Q9NZN8 CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1 0.03 1.412 1 1 1 1 540 59.7 7.66 1 1 213865.875 498709.5625 1 1 cell differentiation;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding Pf04153 4848 ENSG00000111596.11 CNOT2 12 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA RNA degradation 0 High Q5EBL2 Zinc finger protein 628 OS=Homo sapiens OX=9606 GN=ZNF628 PE=1 SV=3 0.001 4.018 1 1 1 1 1059 110.8 8.29 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 89887 ENSG00000197483.9 ZNF628 19 0 High Q9H5Q4 "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" 0.004 2.239 2 1 1 1 396 45.3 9.19 1 1 1739520 468148.0625 1 1 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;RNA binding Pf00398 64216 ENSG00000162851.7 TFB2M 1 Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis 0 High Q13352 Centromere protein R OS=Homo sapiens OX=9606 GN=ITGB3BP PE=1 SV=2 0 4.623 9 1 1 1 177 20.2 9.07 1 1 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane;nucleus protein binding;signal transducer activity Pf06729 23421 ENSG00000142856.16 ITGB3BP 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Signalling by NGF; NRIF signals cell death from the nucleus; Deposition of new CENPA-containing nucleosomes at the centromere 0 High Q9UBD5 Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1 0.001 3.469 3 1 1 1 711 82.2 7.61 1 1 cell organization and biogenesis;cell proliferation;metabolic process nucleus DNA binding;protein binding Pf07034 23595 ENSG00000135336.14 ORC3 6 M/G1 Transition; CDT1 association with the CDC6:ORC:origin complex; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; Association of licensing factors with the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Removal of licensing factors from origins Cell cycle 0 High Q13011 "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" 0.008 1.929 2 1 1 1 328 35.8 8 1 1 284314496 500084.75 340791.1563 1 1 1 metabolic process membrane;mitochondrion catalytic activity;protein binding Pf00378 1891 ENSG00000282853.1; ENSG00000104823.8 ECH1 19; CHR_HG26_PATCH Peroxisome 0 Medium Q9ULK4 Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2 0.016 1.669 1 1 1 1 1368 156.4 7.4 1 1 3370.542969 201932.8125 1 1 metabolic process;regulation of biological process nucleus protein binding Pf11573 9439 ENSG00000112282.17 MED23 6 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 Medium Q86SQ0 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens OX=9606 GN=PHLDB2 PE=1 SV=2 0.025 1.523 1 1 1 1 1253 142.1 7.43 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane catalytic activity;motor activity;protein binding "Pf00169, Pf01576, Pf02463, Pf03938, Pf04111, Pf04156, Pf05483, Pf05667, Pf09730, Pf09731, Pf12128, Pf13166, Pf13851, Pf13868, Pf14942, Pf14943, Pf14992" 90102 ENSG00000144824.20 PHLDB2 3 0 Medium Q16527 Cysteine and glycine-rich protein 2 OS=Homo sapiens OX=9606 GN=CSRP2 PE=1 SV=3 0.015 1.72 8 1 1 1 193 20.9 8.62 1 1 5686232 459566.75 529564.8125 1 1 1 cell differentiation;development nucleus metal ion binding;protein binding Pf00412 1466 ENSG00000175183.9 CSRP2 12 0 High Q15185 Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1 0.001 3.136 8 1 1 1 160 18.7 4.54 1 1 3768100.75 2037906.375 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding Pf04969 10728 ENSG00000110958.15 PTGES3 12 Attenuation phase; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSP90 chaperone cycle for steroid hormone receptors (SHR); Aryl hydrocarbon receptor signalling; HSF1 activation Arachidonic acid metabolism; Metabolic pathways 0 High Q99653 Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3 0.003 2.506 6 1 1 1 195 22.4 5.1 1 1 900132.0625 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus enzyme regulator activity;metal ion binding;protein binding;transporter activity "Pf00036, Pf12174, Pf13405, Pf13499, Pf13833" 11261 ENSG00000187446.11 CHP1 15 Hyaluronan uptake and degradation 0 Medium Q9C0J8 pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2 0.031 1.405 1 1 1 1 1336 145.8 9.17 1 1 232058.0625 233586.4219 1 1 metabolic process;response to stimulus;transport nucleus protein binding;RNA binding Pf00400 55339 ENSG00000136709.11 WDR33 2 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs mRNA surveillance pathway 0 Medium O60942 mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1 0.032 1.388 2 1 1 1 597 68.5 8.13 1 1 19609656 39145.92969 23809.81445 1 1 1 metabolic process;response to stimulus nucleus catalytic activity;nucleotide binding;protein binding "Pf00782, Pf01068, Pf01331, Pf03919" 8732 ENSG00000111880.15 RNGTT 6 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Capping mRNA surveillance pathway 0 Medium Q96NU0 Contactin-associated protein-like 3B OS=Homo sapiens OX=9606 GN=CNTNAP3B PE=2 SV=3 0.035 1.321 1 1 1 1 1288 140.3 7.4 1 1 340787.6563 462162.875 1 1 0 High Q9H0X4 Protein FAM234A OS=Homo sapiens OX=9606 GN=FAM234A PE=1 SV=1 0.001 3.555 2 1 1 1 552 59.6 6.28 1 1 233425.0156 1 cell surface;membrane 83986 ENSG00000167930.15 ITFG3; FAM234A 16 0 Medium Q9HCY8 Protein S100-A14 OS=Homo sapiens OX=9606 GN=S100A14 PE=1 SV=1 0.015 1.732 7 1 1 1 104 11.7 5.24 1 1 210029.0313 1 cell death;defense response;regulation of biological process;response to stimulus cytoplasm;cytosol metal ion binding;protein binding Pf01023 57402 ENSG00000189334.8 S100A14 1 0 High Q9NYB9 Abl interactor 2 OS=Homo sapiens OX=9606 GN=ABI2 PE=1 SV=1 0 4.906 3 1 1 1 513 55.6 6.16 1 1 141946.7969 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol DNA binding;enzyme regulator activity;protein binding "Pf00018, Pf07653, Pf07815, Pf14604" 10152 ABI2 2 Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs Regulation of actin cytoskeleton 0 Medium P17021 Zinc finger protein 17 OS=Homo sapiens OX=9606 GN=ZNF17 PE=2 SV=3 0.041 1.21 2 1 1 1 662 77.2 8.44 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 7565 ENSG00000186272.12 ZNF17 19 Generic Transcription Pathway 0 High P51504 Zinc finger protein 80 OS=Homo sapiens OX=9606 GN=ZNF80 PE=2 SV=2 0.002 2.843 5 1 1 1 273 31.2 8.73 1 1 1840607.625 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 7634 ENSG00000174255.6 ZNF80 3 0 Medium P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2 0.048 1.131 4 1 1 1 724 83.5 6.16 1 1 cell death;cell differentiation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00017, Pf00018, Pf00620" 5295 ENSG00000145675.14 PIK3R1 5 "PI3K Cascade; Signaling by FGFR4 in disease; Downstream TCR signaling; PI-3K cascade:FGFR3; PI3K events in ERBB4 signaling; DAP12 signaling; PI-3K cascade:FGFR4; Regulation of signaling by CBL; Signaling by cytosolic FGFR1 fusion mutants; MET activates PI3K/AKT signaling; Role of phospholipids in phagocytosis; G alpha (12/13) signalling events; Constitutive Signaling by EGFRvIII; VEGFA-VEGFR2 Pathway; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; PI-3K cascade:FGFR2; RET signaling; Synthesis of PIPs at the plasma membrane; PI3K events in ERBB2 signaling; PI-3K cascade:FGFR1; Interleukin-4 and 13 signaling; Role of LAT2/NTAL/LAB on calcium mobilization; Tie2 Signaling; Signaling by FGFR2 in disease; Signaling by FGFR3 fusions in cancer; G beta:gamma signalling through PI3Kgamma; Interleukin-7 signaling; Downstream signal transduction; GP1b-IX-V activation signalling; Signaling by FGFR3 point mutants in cancer; PI3K/AKT activation; Nephrin family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Gastrin-CREB signalling pathway via PKC and MAPK; Signaling by SCF-KIT; GAB1 signalosome" Viral carcinogenesis; Chagas disease (American trypanosomiasis); Longevity regulating pathway - multiple species; Amoebiasis; T cell receptor signaling pathway; TNF signaling pathway; Osteoclast differentiation; Hepatitis B; Insulin signaling pathway; HIF-1 signaling pathway; Central carbon metabolism in cancer; Pancreatic cancer; FoxO signaling pathway; Prolactin signaling pathway; Phospholipase D signaling pathway; cGMP-PKG signaling pathway; Chronic myeloid leukemia; Epstein-Barr virus infection; Neurotrophin signaling pathway; B cell receptor signaling pathway; VEGF signaling pathway; Acute myeloid leukemia; Rap1 signaling pathway; Non-small cell lung cancer; Progesterone-mediated oocyte maturation; Oxytocin signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Type II diabetes mellitus; Natural killer cell mediated cytotoxicity; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; Glioma; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; AGE-RAGE signaling pathway in diabetic complications; Renal cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; HTLV-I infection; Toxoplasmosis; Apoptosis; Focal adhesion; Jak-STAT signaling pathway; Proteoglycans in cancer; Choline metabolism in cancer; AMPK signaling pathway; mTOR signaling pathway; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Non-alcoholic fatty liver disease (NAFLD); Sphingolipid signaling pathway; Bacterial invasion of epithelial cells; Measles; Small cell lung cancer; Toll-like receptor signaling pathway; Fc epsilon RI signaling pathway; Inflammatory mediator regulation of TRP channels; Hepatitis C; Ras signaling pathway; Fc gamma R-mediated phagocytosis; Endocrine resistance; Chemokine signaling pathway; Axon guidance; Signaling pathways regulating pluripotency of stem cells; cAMP signaling pathway; Influenza A; Estrogen signaling pathway; Regulation of lipolysis in adipocytes; Insulin resistance; Cholinergic synapse; Longevity regulating pathway; PI3K-Akt signaling pathway; Platelet activation; Platinum drug resistance 0 High Q16718 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Homo sapiens OX=9606 GN=NDUFA5 PE=1 SV=3 0.004 2.368 14 1 1 1 116 13.5 5.99 1 1 260313.9375 511508.1563 530364.875 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;protein binding Pf04716 4698 ENSG00000128609.14 NDUFA5 7 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 Low Q9Y493 Zonadhesin OS=Homo sapiens OX=9606 GN=ZAN PE=2 SV=5 0.069 0.92 0 1 1 1 2812 305.4 6.1 1 1 7169323 177346.125 1 1 0 Medium P45973 Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1 0.03 1.41 7 1 1 1 191 22.2 5.86 1 1 104462.0938 946561.875 1 1 coagulation;regulation of biological process chromosome;nucleus protein binding "Pf00385, Pf01393" 23468 ENSG00000094916.15 CBX5 12 SUMOylation of chromatin organization proteins; Factors involved in megakaryocyte development and platelet production; Transcriptional Regulation by E2F6 0 High Q6NZY4 Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2 0.001 4.076 2 1 1 1 707 78.5 4.87 1 1 272436.375 2196636 1 1 metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf00098, Pf04046" 55596 ENSG00000033030.13 ZCCHC8 12 0 Low O00423 Echinoderm microtubule-associated protein-like 1 OS=Homo sapiens OX=9606 GN=EML1 PE=1 SV=3 0.053 1.074 1 1 1 1 815 89.8 7.06 1 1 197510.0156 177520.4688 1 1 cell differentiation;cell organization and biogenesis;cell proliferation cytoplasm;cytoskeleton;cytosol metal ion binding;protein binding "Pf00400, Pf03451" 2009 ENSG00000066629.16 EML1 14 0 Medium O60225 Protein SSX5 OS=Homo sapiens OX=9606 GN=SSX5 PE=1 SV=3 0.047 1.148 5 1 1 1 188 21.6 9.36 1 1 metabolic process;regulation of biological process nucleus protein binding Pf09514 6758 ENSG00000165583.14 SSX5 X 0 High Q9NYZ3 G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=3 0.003 2.582 2 1 1 1 720 76.6 9.39 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding Pf15259 51512 GTSE1 22 The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M Checkpoints p53 signaling pathway 0 Low Q96RP7 Galactose-3-O-sulfotransferase 4 OS=Homo sapiens OX=9606 GN=GAL3ST4 PE=1 SV=1 0.067 0.952 1 1 1 1 486 54.1 10.18 1 1 10657334 1 cell communication;metabolic process Golgi;membrane catalytic activity;nucleotide binding Pf06990 79690 ENSG00000197093.10 GAL3ST4 7 0 Medium Q96RE7 Nucleus accumbens-associated protein 1 OS=Homo sapiens OX=9606 GN=NACC1 PE=1 SV=1 0.013 1.806 2 1 1 1 527 57.2 5.74 1 1 421024.4375 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding "Pf00651, Pf10523" 112939 ENSG00000160877.5 NACC1 19 0 High Q8ND24 RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2 0.003 2.443 3 1 1 1 703 77.6 6.95 1 1 290349.8125 1 metal ion binding;protein binding "Pf00097, Pf12678, Pf12906, Pf13639, Pf14634" 257160 ENSG00000167257.10 RNF214 11 0 High Q9HAY6 "Beta,beta-carotene 15,15'-dioxygenase OS=Homo sapiens OX=9606 GN=BCO1 PE=1 SV=1" 0.002 3.068 1 1 1 1 547 62.6 6.67 1 1 243867.8594 6795.771484 720.7914429 1 1 1 Acetyl [N-Term] metabolic process cytosol catalytic activity;metal ion binding Pf03055 53630 ENSG00000135697.9 BCMO1; BCO1 16 Signaling by GPCR; Retinoid metabolism and transport Retinol metabolism; Metabolic pathways 0 Low Q8NEA4 F-box only protein 36 OS=Homo sapiens OX=9606 GN=FBXO36 PE=2 SV=2 0.058 1.043 3 1 1 1 188 22.1 8.43 1 1 263316.7813 841175.1875 250480.7188 1 1 1 protein binding "Pf00646, Pf12937" 130888 ENSG00000153832.11 FBXO36 2 0 High O95243 Methyl-CpG-binding domain protein 4 OS=Homo sapiens OX=9606 GN=MBD4 PE=1 SV=1 0.001 4.09 2 1 1 1 580 66 8.82 1 1 metabolic process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;protein binding "Pf00730, Pf01429" 8930 ENSG00000129071.9 MBD4 3 Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1 Base excision repair 0 High Q9NRZ9 Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1 0.001 4.1 3 1 1 1 838 97 7.93 1 1 206906064 395200.1563 29922.9082 8962.827148 1 1 1 1 cell division;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process nucleus catalytic activity;nucleotide binding;protein binding "Pf00176, Pf00271, Pf11496" 3070 ENSG00000119969.14 HELLS 10 0 Medium O75935 Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1 0.027 1.491 4 1 1 1 186 21.1 5.47 1 1 267036.3125 1 cell division;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity Pf07426 11258 ENSG00000137100.15 DCTN3 9 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) 0 Low Q7L8J4 SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1 0.073 0.889 2 1 1 1 393 43.5 5.77 1 1 166749.9688 12652274 1 1 regulation of biological process;response to stimulus cytoplasm enzyme regulator activity;protein binding Pf05276 80851 ENSG00000175137.10 SH3BP5L 1 0 High Q8TBF4 Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=ZCRB1 PE=1 SV=2 0 8.014 8 1 1 1 217 24.6 8.53 1 1 metabolic process nucleus;spliceosomal complex metal ion binding;RNA binding "Pf00076, Pf00098, Pf13893, Pf14259" 85437 ENSG00000139168.7 ZCRB1 12 mRNA Splicing - Minor Pathway 0 High P60981 Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3 0.001 4.023 7 1 1 1 165 18.5 7.85 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding Pf00241 11034 ENSG00000125868.15 DSTN 20 0 High Q8NDZ4 Divergent protein kinase domain 2A OS=Homo sapiens OX=9606 GN=DIPK2A PE=1 SV=1 0 4.496 3 1 1 1 430 49.5 8.53 1 1 549167.9375 1 cell proliferation;regulation of biological process extracellular;Golgi;membrane Pf12260 205428 ENSG00000181744.8 C3orf58 3 0 High O14967 Calmegin OS=Homo sapiens OX=9606 GN=CLGN PE=1 SV=1 0.001 3.666 3 1 1 1 610 70 4.69 1 1 604885 759150.875 1 1 cell organization and biogenesis;metabolic process endoplasmic reticulum;membrane metal ion binding;protein binding Pf00262 1047 ENSG00000153132.12 CLGN 4 0 Medium Q75V66 Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 PE=1 SV=1 0.027 1.484 1 1 1 1 913 107.1 6.8 1 1 674054.25 551113.9375 1 1 transport endoplasmic reticulum;membrane protein binding;transporter activity Pf04547 203859 ENSG00000171714.10 ANO5 11 Stimuli-sensing channels 0 High Q9H6R7 WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1 0.004 2.218 1 1 1 1 721 79.1 6.7 1 1 cell organization and biogenesis protein binding Pf15390 80304 ENSG00000163026.11 C2orf44; WDCP 2 0 High Q9Y512 Sorting and assembly machinery component 50 homolog OS=Homo sapiens OX=9606 GN=SAMM50 PE=1 SV=3 0.004 2.145 1 1 1 1 469 51.9 6.9 1 1 322107.625 316200.8438 1 1 cell organization and biogenesis;transport cytoplasm;membrane;mitochondrion protein binding "Pf01103, Pf07244" 25813 ENSG00000100347.14 SAMM50 22 Cristae formation; Mitochondrial protein import; Metabolism of proteins 0 High Q15165 Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 PE=1 SV=4 0.002 2.829 3 1 1 1 354 39.4 5.6 1 1 1249993.875 668688.8125 1 1 0 High O15182 Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2 0 4.563 7 1 1 1 167 19.5 4.74 1 1 2010269.125 1 cell division;cell organization and biogenesis cytoplasm;cytoskeleton;nucleus metal ion binding;protein binding "Pf00036, Pf13405, Pf13499, Pf13833" 1070 ENSG00000153140.8 CETN3 5 0 High P27169 Serum paraoxonase/arylesterase 1 OS=Homo sapiens OX=9606 GN=PON1 PE=1 SV=3 0.001 3.58 3 1 1 1 355 39.7 5.22 1 1 433448.4688 545575.875 481920.7188 1 1 1 metabolic process;regulation of biological process;response to stimulus extracellular antioxidant activity;catalytic activity;metal ion binding;protein binding "Pf01731, Pf03088, Pf08450" 5444 ENSG00000005421.8 PON1 7 Synthesis of 5-eicosatetraenoic acids Metabolic pathways 0 High Q8IXM2 Chromatin complexes subunit BAP18 OS=Homo sapiens OX=9606 GN=BAP18 PE=1 SV=1 0 5.603 8 1 1 1 172 17.9 7.33 1 1 cell organization and biogenesis cytosol;nucleus DNA binding;protein binding Pf00249 124944; 100529209 ENSG00000258315.5 C17orf49; RNASEK-C17orf49 17 0 High P61165 Transmembrane protein 258 OS=Homo sapiens OX=9606 GN=TMEM258 PE=1 SV=1 0.001 3.362 10 1 1 1 79 9.1 5.83 1 1 789818.25 1 Acetyl [N-Term] metabolic process endoplasmic reticulum;membrane Pf05251 746 ENSG00000134825.15 C11orf10; TMEM258 11 0 High Q9NTM9 Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1 0.001 4.013 5 1 1 1 273 29.3 8.18 1 1 331536.5625 1 cell organization and biogenesis;transport cytoplasm;cytosol;nucleus metal ion binding;protein binding Pf03932 51076 ENSG00000119929.12 CUTC 10 Ion transport by P-type ATPases 0 High Q8WV22 Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5 0.004 2.149 3 1 1 1 266 30.8 7.47 1 1 1129383.75 1 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;metal ion binding;protein binding "Pf07574, Pf08746" 197370 ENSG00000169189.16 NSMCE1 16 SUMOylation of DNA damage response and repair proteins 0 High Q7Z2K6 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens OX=9606 GN=ERMP1 PE=1 SV=2 0.001 3.487 1 1 1 1 904 100.2 7.52 1 1 656168.8125 342421.0625 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf04389 79956 ENSG00000099219.13 ERMP1 9 0 High Q9H875 PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1 0.002 2.765 5 1 1 1 184 21 9.79 1 1 metabolic process;regulation of biological process nucleus enzyme regulator activity;protein binding;RNA binding Pf06658 79706 ENSG00000128563.13 PRKRIP1 7 0 High Q8WVI0 Small integral membrane protein 4 OS=Homo sapiens OX=9606 GN=SMIM4 PE=1 SV=2 0.003 2.652 16 1 1 1 70 8.7 10.87 1 1 605772.0625 525341.25 1 1 membrane;mitochondrion Pf15114 440957 ENSG00000168273.7 SMIM4 3 0 High Q8NEM7 Transcription factor SPT20 homolog OS=Homo sapiens OX=9606 GN=SUPT20H PE=1 SV=2 0 6.057 2 1 1 1 779 85.7 8.48 1 1 1529342.75 1 development;metabolic process;regulation of biological process nucleus protein binding Pf12090 55578 ENSG00000102710.19 FAM48A; SUPT20H 13 HATs acetylate histones 0 Medium Q9H2V7 Protein spinster homolog 1 OS=Homo sapiens OX=9606 GN=SPNS1 PE=1 SV=1 0.015 1.753 3 1 1 1 528 56.6 6.64 1 1 425104.5 1 regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity "Pf00083, Pf07690" 83985 ENSG00000169682.17 SPNS1 16 0 Medium Q96JB1 "Dynein heavy chain 8, axonemal OS=Homo sapiens OX=9606 GN=DNAH8 PE=1 SV=2" 0.034 1.369 0 1 1 1 4490 514.3 6.32 1 1 222870.8594 24539064 1 1 cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf03028, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781" 1769 ENSG00000124721.17 DNAH8 6 Huntington's disease 0 High Q8N6M0 Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1 0 5.358 6 1 1 1 293 33.8 6.05 1 1 152111.2656 1 Acetyl [N-Term] metabolic process catalytic activity "Pf02338, Pf10275" 51633 ENSG00000155100.10 OTUD6B 8 0 Medium Q9HCC0 "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" 0.038 1.265 3 1 1 1 563 61.3 7.68 1 1 358825.3125 1 cell organization and biogenesis;metabolic process cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding Pf01039 64087 ENSG00000131844.15 MCCC2 5 Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency "Metabolic pathways; Valine, leucine and isoleucine degradation" 0 Medium Q5K4L6 Solute carrier family 27 member 3 OS=Homo sapiens OX=9606 GN=SLC27A3 PE=2 SV=4 0.038 1.263 1 1 1 1 683 73.5 7.09 1 1 260223.3125 125247.3594 1 1 metabolic process catalytic activity "Pf00501, Pf13193" 0 High P17509 Homeobox protein Hox-B6 OS=Homo sapiens OX=9606 GN=HOXB6 PE=1 SV=4 0.002 2.853 8 1 1 1 224 25.4 8.21 1 1 development;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding Pf00046 3216 ENSG00000108511.9 HOXB6 17 0 High Q8NFP7 Diphosphoinositol polyphosphate phosphohydrolase 3-alpha OS=Homo sapiens OX=9606 GN=NUDT10 PE=1 SV=1 0 5.032 12 1 1 1 164 18.5 5.68 1 1 1763313.75 1 metabolic process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding Pf00293 170685 ENSG00000122824.10 NUDT10 X Synthesis of pyrophosphates in the cytosol 0 Medium P57057 Glucose-6-phosphate exchanger SLC37A1 OS=Homo sapiens OX=9606 GN=SLC37A1 PE=2 SV=2 0.035 1.33 1 1 1 1 533 57.6 8.31 1 1 2321503.75 48725.17578 1 1 transport endoplasmic reticulum;membrane transporter activity Pf07690 54020 ENSG00000160190.13 SLC37A1 21 Gluconeogenesis 0 Medium Q9HCB6 Spondin-1 OS=Homo sapiens OX=9606 GN=SPON1 PE=1 SV=2 0.035 1.316 1 1 1 1 807 90.9 6.11 1 1 9888835 1 metabolic process extracellular;organelle lumen metal ion binding;protein binding "Pf00090, Pf02014, Pf06468" 10418 ENSG00000262655.3 SPON1 11 O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS) 0 Medium Q9NYK5 "39S ribosomal protein L39, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" 0.011 1.842 2 1 1 1 338 38.7 7.65 1 1 1354529.75 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome nucleotide binding;RNA binding Pf02824 54148 ENSG00000154719.13 MRPL39 21 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 Medium Q8IYU2 E3 ubiquitin-protein ligase HACE1 OS=Homo sapiens OX=9606 GN=HACE1 PE=1 SV=2 0.032 1.396 2 1 1 1 909 102.3 5.92 1 1 10934887 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus catalytic activity;protein binding "Pf00023, Pf00632, Pf12796, Pf13606, Pf13637, Pf13857" 57531 ENSG00000085382.11 HACE1 6 Antigen processing: Ubiquitination & Proteasome degradation 0 Medium Q86V35 Calcium-binding protein 7 OS=Homo sapiens OX=9606 GN=CABP7 PE=1 SV=1 0.018 1.642 3 1 1 1 215 24.4 4.67 1 1 724415.75 1 cytoplasm;Golgi;membrane metal ion binding "Pf00036, Pf13202, Pf13405, Pf13499, Pf13833" 164633 ENSG00000100314.3 CABP7 22 0 Medium Q86UT8 Coiled-coil domain-containing protein 84 OS=Homo sapiens OX=9606 GN=CCDC84 PE=1 SV=1 0.017 1.657 3 1 1 1 332 38 8.22 1 1 176025.5625 1937550.875 1 1 Pf14968 338657 ENSG00000280975.2; ENSG00000186166.8 CCDC84 11; CHR_HG2217_PATCH 0 High P13073 "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" 0.001 3.694 7 1 1 1 169 19.6 9.51 1 1 476746.1875 1 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity Pf02936 1327 ENSG00000131143.8 COX4I1 16 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 Medium Q30167 "HLA class II histocompatibility antigen, DRB1-10 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" 0.019 1.621 6 1 1 1 266 30 7.75 1 1 270632.5 449716.7813 408782.2188 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;endosome;Golgi;membrane;vacuole protein binding "Pf00969, Pf07654" 3123 HLA-DRB1 6 PD-1 signaling; Translocation of ZAP-70 to Immunological synapse; MHC class II antigen presentation; Downstream TCR signaling; Generation of second messenger molecules; Interferon gamma signaling; Phosphorylation of CD3 and TCR zeta chains 0 Low Q6VN20 Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1 0.055 1.065 2 1 1 1 620 67.2 6.77 1 1 2897180 1090516.375 1 1 cytoplasm;cytosol;nucleus protein binding "Pf00622, Pf10607" 57610 ENSG00000141084.10 RANBP10 16 MET activates RAS signaling 0 High P14406 "Cytochrome c oxidase subunit 7A2, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2 PE=1 SV=1" 0.003 2.542 12 1 1 1 83 9.4 9.76 1 1 125022.0938 996824.125 425678.9688 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02238 1347 COX7A2 6 Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Cardiac muscle contraction 0 Medium O14974 Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1 0.046 1.164 1 1 1 1 1030 115.2 5.4 1 1 2103480.25 2127704 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol enzyme regulator activity;protein binding;signal transducer activity "Pf00023, Pf03961, Pf12796, Pf13606, Pf13637, Pf13857" 4659 ENSG00000058272.16 PPP1R12A 12 RHO GTPases activate PAKs; RHO GTPases Activate ROCKs; Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate PKNs; RHO GTPases activate CIT Vascular smooth muscle contraction; cGMP-PKG signaling pathway; Oxytocin signaling pathway; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; cAMP signaling pathway; Platelet activation 0 High Q9Y2Z4 "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" 0 6.012 4 1 1 1 477 53.2 8.98 1 1 115390.0391 1371909.75 1 1 metabolic process cytoplasm;cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding Pf00579 51067 ENSG00000139131.12 YARS2 12 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 Medium Q9UHG3 Prenylcysteine oxidase 1 OS=Homo sapiens OX=9606 GN=PCYOX1 PE=1 SV=3 0.028 1.455 2 1 1 1 505 56.6 6.18 1 1 172664.7344 737180.375 399451.3438 386728 1 1 1 1 metabolic process;transport membrane;vacuole catalytic activity;transporter activity "Pf01593, Pf07156" 51449 ENSG00000116005.11 PCYOX1 2 Terpenoid backbone biosynthesis 0 Medium Q01085 Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1 0.041 1.209 2 1 1 1 375 41.6 7.74 1 1 1859470 650110.1875 1 1 cell death;cell division;defense response;regulation of biological process;response to stimulus cytoplasm;nucleus;vacuole DNA binding;RNA binding "Pf00076, Pf13893, Pf14259" 7073 ENSG00000151923.17 TIAL1 10 FGFR2 alternative splicing 0 Medium O75072 Fukutin OS=Homo sapiens OX=9606 GN=FKTN PE=1 SV=2 0.013 1.786 1 1 1 1 461 53.7 8.41 1 1 399966.6875 1 metabolic process;regulation of biological process endoplasmic reticulum;Golgi;membrane;nucleus catalytic activity Pf04991 2218 ENSG00000106692.13 FKTN 9 0 High Q96MG8 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PCMTD1 PE=1 SV=2 0.006 2.027 3 1 1 1 357 40.7 5.66 1 1 860865.875 1 metabolic process cytoplasm;membrane catalytic activity "Pf01135, Pf12847, Pf13847" 115294 ENSG00000168300.13 PCMTD1 8 0 High Q9NR48 Histone-lysine N-methyltransferase ASH1L OS=Homo sapiens OX=9606 GN=ASH1L PE=1 SV=2 0 4.923 1 1 1 1 2969 332.6 9.39 1 1 137748.9375 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process chromosome;Golgi;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00439, Pf00628, Pf00856, Pf01426" 55870 ENSG00000116539.12 ASH1L 1 PKMTs methylate histone lysines Tight junction; Lysine degradation 0 Medium Q9H3U1 Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1 0.013 1.792 1 1 1 1 944 103 6.07 1 1 1365397.625 478462.4063 697995.25 1 1 1 cell differentiation;development;metabolic process cytoplasm;cytosol;Golgi;nucleus protein binding "Pf00515, Pf07719, Pf11701, Pf12895, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559" 55898 ENSG00000140553.17 UNC45A 15 0 High Q9Y606 tRNA pseudouridine synthase A OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3 0.001 3.33 2 1 1 1 427 47.4 8.41 1 1 1406119.625 1 cell organization and biogenesis;metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;RNA binding Pf01416 80324 ENSG00000177192.13 PUS1 12 tRNA modification in the mitochondrion 0 High Q9UBB4 Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1 0.005 2.069 2 1 1 1 475 53.5 5.25 1 1 cell organization and biogenesis cytoplasm;cytosol;membrane protein binding Pf09759 25814 ENSG00000130638.16 ATXN10 22 0 Medium Q9H4K7 Mitochondrial ribosome-associated GTPase 2 OS=Homo sapiens OX=9606 GN=MTG2 PE=1 SV=1 0.027 1.467 3 1 1 1 406 43.9 9.45 1 1 6529000.5 346279.3125 1 1 metabolic process;regulation of biological process membrane;mitochondrion;organelle lumen;ribosome catalytic activity;metal ion binding;nucleotide binding "Pf00025, Pf01018, Pf01926, Pf02421, Pf08438, Pf10662" 26164 ENSG00000101181.17 GTPBP5; MTG2 20 0 Low Q86YP4 Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1 0.069 0.918 2 1 1 1 633 68 9.94 1 1 3443750.5 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding 54815 ENSG00000167491.17 GATAD2A 19 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation 0 High Q13064 Probable E3 ubiquitin-protein ligase makorin-3 OS=Homo sapiens OX=9606 GN=MKRN3 PE=1 SV=1 0.003 2.518 1 1 1 1 507 55.6 5.73 1 1 2984691 1 metabolic process catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf13639, Pf13923" 7681 ENSG00000179455.7 MKRN3 15 0 Medium P02760 Protein AMBP OS=Homo sapiens OX=9606 GN=AMBP PE=1 SV=1 0.048 1.117 2 1 1 1 352 39 6.25 1 1 722501.75 1 metabolic process;regulation of biological process;transport cell surface;extracellular;membrane enzyme regulator activity;protein binding "Pf00014, Pf00061" 259 ENSG00000106927.11 AMBP 9 Scavenging of heme from plasma 0 Medium Q8N271 Prominin-2 OS=Homo sapiens OX=9606 GN=PROM2 PE=1 SV=1 0.033 1.376 1 1 1 1 834 91.8 6.15 1 1 1475680.5 1 regulation of biological process cell surface;membrane Pf05478 150696 ENSG00000155066.15 PROM2 2 0 High Q92833 Protein Jumonji OS=Homo sapiens OX=9606 GN=JARID2 PE=1 SV=2 0 5.794 1 1 1 1 1246 138.6 9.38 1 1 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process mitochondrion;nucleus catalytic activity;DNA binding;protein binding "Pf01388, Pf02373, Pf02375, Pf02928" 3720 ENSG00000008083.13 JARID2 6 PRC2 methylates histones and DNA Signaling pathways regulating pluripotency of stem cells 0 High Q9NS84 Carbohydrate sulfotransferase 7 OS=Homo sapiens OX=9606 GN=CHST7 PE=1 SV=2 0.007 2.005 1 1 1 1 486 54.2 9.64 1 1 396818.4375 306631.0625 344944.3594 1 1 1 metabolic process Golgi;membrane catalytic activity 56548 ENSG00000147119.3 CHST7 X Chondroitin sulfate biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 Medium Q9UBB9 Tuftelin-interacting protein 11 OS=Homo sapiens OX=9606 GN=TFIP11 PE=1 SV=1 0.021 1.577 1 1 1 1 837 96.8 5.67 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;spliceosomal complex DNA binding;protein binding "Pf01585, Pf07842, Pf12457, Pf12656" 24144 ENSG00000100109.16 TFIP11 22 mRNA Splicing - Major Pathway 0 Medium Q9UIQ6 Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3 0.011 1.854 1 1 1 1 1025 117.3 5.73 1 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf01433, Pf11838, Pf13485" 4012 ENSG00000113441.15 LNPEP 5 Translocation of GLUT4 to the plasma membrane; Antigen processing: Ubiquitination & Proteasome degradation; Endosomal/Vacuolar pathway Renin-angiotensin system 0 Medium P37802 Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3 0.015 1.726 6 1 1 1 199 22.4 8.25 1 1 439228.0313 165693.3438 1 1 cell differentiation;transport cytosol;extracellular protein binding "Pf00307, Pf00402" 8407 ENSG00000158710.14 TAGLN2 1 Platelet degranulation 0 High Q8IZT6 Abnormal spindle-like microcephaly-associated protein OS=Homo sapiens OX=9606 GN=ASPM PE=1 SV=2 0 5.535 0 1 1 1 3477 409.5 10.45 1 1 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton;nucleus protein binding "Pf00307, Pf11971" 259266 ENSG00000066279.17 ASPM 1 0 High Q6PIY7 Poly(A) RNA polymerase GLD2 OS=Homo sapiens OX=9606 GN=TENT2 PE=1 SV=1 0 5.7 3 1 1 1 484 56 9.38 1 1 825656 1 cell differentiation;metabolic process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf03828 167153 ENSG00000164329.13 PAPD4 5 0 High Q86TN4 tRNA 2'-phosphotransferase 1 OS=Homo sapiens OX=9606 GN=TRPT1 PE=1 SV=2 0 6.924 9 1 1 1 253 27.7 9.98 1 1 658148.4375 1 metabolic process;regulation of biological process catalytic activity Pf01885 83707 ENSG00000149743.13 TRPT1 11 0 High O75489 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" 0.001 4.274 5 1 1 1 264 30.2 7.5 1 1 339700.1563 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion;organelle lumen catalytic activity;protein binding Pf00329 4722 ENSG00000213619.9 NDUFS3 11 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 Low Q9UJX4 Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2 0.055 1.062 1 1 1 1 755 85 6.87 1 1 614999.5625 469483.5938 1 1 cell division;metabolic process;regulation of biological process cytosol;nucleus protein binding Pf12862 51433 ENSG00000089053.12 ANAPC5 12 APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP) Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 High Q9BT67 NEDD4 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=NDFIP1 PE=1 SV=1 0.001 3.161 8 1 1 1 221 24.9 4.68 1 1 251899.0625 55801.06641 42949.75 1 1 1 Met-loss+Acetyl [N-Term] cellular homeostasis;regulation of biological process;response to stimulus;transport endosome;extracellular;Golgi;membrane protein binding;signal transducer activity Pf10176 80762 ENSG00000131507.10 NDFIP1 5 0 Medium Q13257 Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1 0.016 1.675 3 1 1 1 205 23.5 5.08 1 1 640506.375 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;cytoskeleton;cytosol;nucleus protein binding Pf02301 4085 ENSG00000164109.13 MAD2L1 4 Inactivation of APC/C via direct inhibition of the APC/C complex; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; APC-Cdc20 mediated degradation of Nek2A Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 Low P78344 Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1 0.054 1.063 1 1 1 1 907 102.3 7.14 1 1 891207.1875 1 cell death;metabolic process;regulation of biological process cytosol;membrane protein binding;RNA binding "Pf02020, Pf02847, Pf02854" 1982 ENSG00000110321.16 EIF4G2 11 ISG15 antiviral mechanism RNA transport; Viral myocarditis 0 Medium Q96EL3 "39S ribosomal protein L53, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1" 0.022 1.592 6 1 1 1 112 12.1 8.76 1 1 1482035.5 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding Pf10780 116540 ENSG00000204822.6 MRPL53 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 Low A8MUZ8 Putative zinc finger protein 705G OS=Homo sapiens OX=9606 GN=ZNF705G PE=2 SV=2 0.063 0.996 3 1 1 1 300 34.7 9.22 1 1 9554253 2750899 2796637.25 1 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 100131980 ENSG00000215372.6 ZNF705G 8 Generic Transcription Pathway 0 High Q8WUB8 PHD finger protein 10 OS=Homo sapiens OX=9606 GN=PHF10 PE=1 SV=3 0.001 4.269 3 1 1 1 498 56 6.62 1 1 3944546.25 1 metabolic process;regulation of biological process nucleus metal ion binding;protein binding "Pf00628, Pf13831" 55274 ENSG00000130024.14 PHF10 6 0 High Q9H3K2 Growth hormone-inducible transmembrane protein OS=Homo sapiens OX=9606 GN=GHITM PE=1 SV=2 0.001 3.117 3 1 1 1 345 37.2 9.94 1 1 1596853.25 2789746 1 1 cell death membrane;mitochondrion protein binding 27069 ENSG00000165678.20 GHITM 10 0 High Q5JS37 NHL repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=NHLRC3 PE=2 SV=1 0.001 3.848 4 1 1 1 347 38.3 6.43 1 1 3165068 366731.5 1870044.25 1 1 1 transport extracellular;organelle lumen protein binding Pf01436 387921 ENSG00000188811.13 NHLRC3 13 Neutrophil degranulation 0 High Q8NBA8 DTW domain-containing protein 2 OS=Homo sapiens OX=9606 GN=DTWD2 PE=1 SV=1 0.001 3.307 3 1 1 1 298 33.4 8.68 1 1 1614108.5 1 Pf03942 285605 ENSG00000169570.9 DTWD2 5 0 Medium P61289 Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1 0.027 1.479 3 1 1 1 254 29.5 5.95 1 1 253269.8281 881172.375 1 1 cell death;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;proteasome enzyme regulator activity;protein binding "Pf02251, Pf02252" 10197 ENSG00000131467.10 PSME3 17 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome; Hepatitis C; Antigen processing and presentation 0 Medium Q9BY44 Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3 0.013 1.777 1 1 1 1 585 64.9 8.87 1 1 1105852.75 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm protein binding;RNA binding Pf08662 83939 ENSG00000144895.11 EIF2A 3 0 High Q9NVH0 Exonuclease 3'-5' domain-containing protein 2 OS=Homo sapiens OX=9606 GN=EXD2 PE=1 SV=2 0.004 2.396 2 1 1 1 621 70.3 8.32 1 1 2183613.5 555430 542387.25 1 1 1 metabolic process;response to stimulus cytoplasm;nucleus catalytic activity;protein binding Pf01612 55218 ENSG00000081177.18 EXD2 14 0 High A2RU67 Protein FAM234B OS=Homo sapiens OX=9606 GN=FAM234B PE=1 SV=1 0.005 2.123 1 1 1 1 622 67 5.02 1 1 565421.9375 1 membrane Pf13360 57613 ENSG00000084444.13 KIAA1467; FAM234B 12 0 Medium Q96DA6 Mitochondrial import inner membrane translocase subunit TIM14 OS=Homo sapiens OX=9606 GN=DNAJC19 PE=1 SV=3 0.029 1.446 7 1 1 1 116 12.5 10.1 1 1 521517.1563 476902.7188 1 1 metabolic process;transport membrane;mitochondrion protein binding Pf00226 131118 ENSG00000205981.6 DNAJC19 3 Mitochondrial protein import; Metabolism of proteins 0 High Q9NP92 "39S ribosomal protein S30, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" 0 6.627 3 1 1 1 439 50.3 7.97 1 1 cell death;cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf07147 10884 ENSG00000112996.10 MRPS30 5 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 Medium Q9H7N4 "Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3" 0.044 1.185 1 1 1 1 1312 139.2 9.25 1 1 metabolic process nucleus protein binding;RNA binding 58506 ENSG00000126461.14 SCAF1 19 0 High Q6W2J9 BCL-6 corepressor OS=Homo sapiens OX=9606 GN=BCOR PE=1 SV=1 0 5.863 1 1 1 1 1755 192.1 6.48 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 54880 ENSG00000183337.16 BCOR X 0 Medium Q8WV16 DDB1- and CUL4-associated factor 4 OS=Homo sapiens OX=9606 GN=DCAF4 PE=1 SV=3 0.035 1.315 2 1 1 1 495 55.7 9.23 1 1 78718.67969 4020440.5 2969673 1 1 1 metabolic process spliceosomal complex protein binding;RNA binding Pf00400 26094 ENSG00000119599.16 DCAF4 14 Neddylation 0 High Q6PGN9 Proline/serine-rich coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=PSRC1 PE=1 SV=1 0.003 2.604 3 1 1 1 363 38.8 11.21 1 1 cell division;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding Pf15259 84722 ENSG00000134222.16 PSRC1 1 0 Medium C9J798 Ras GTPase-activating protein 4B OS=Homo sapiens OX=9606 GN=RASA4B PE=3 SV=2 0.041 1.211 2 1 1 1 803 90.4 7.74 1 1 4967833 1 regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00168, Pf00169, Pf00616, Pf00779" 100271927 ENSG00000170667.14 RASA4B 7 0 High Q9BYR6 Keratin-associated protein 3-3 OS=Homo sapiens OX=9606 GN=KRTAP3-3 PE=1 SV=1 0 4.532 17 1 1 1 98 10.4 5.69 1 1 3783336.5 1 cytosol protein binding;structural molecule activity Pf04579 85293 ENSG00000212899.2; ENSG00000263101.2 KRTAP3-3 17; CHR_HSCHR17_4_CTG4 Keratinization 0 High Q13045 Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2 0.003 2.494 1 1 1 1 1269 144.7 6.05 1 1 Acetyl [N-Term] cell organization and biogenesis;development;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus protein binding "Pf00626, Pf12799, Pf13855" 2314 ENSG00000177731.15; ENSG00000284571.1 FLII 17; CHR_HSCHR17_3_CTG1 0 Low A6NLP5 Tetratricopeptide repeat protein 36 OS=Homo sapiens OX=9606 GN=TTC36 PE=1 SV=1 0.067 0.949 7 1 1 1 189 20.9 5.12 1 1 1009084.625 5288619 1 1 protein binding "Pf00515, Pf13414, Pf13424" 143941 ENSG00000172425.10 TTC36 11 0 Medium Q6NXT6 Transmembrane anterior posterior transformation protein 1 homolog OS=Homo sapiens OX=9606 GN=TAPT1 PE=1 SV=1 0.017 1.653 4 1 1 1 567 64.2 8.28 1 1 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane receptor activity;signal transducer activity Pf05346 202018 ENSG00000169762.16 TAPT1 4 0 Low P51148 Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2 0.051 1.1 6 1 1 1 216 23.5 8.41 1 1 regulation of biological process;response to stimulus;transport endosome;membrane catalytic activity;nucleotide binding;protein binding "Pf00009, Pf00025, Pf00071, Pf04670, Pf08477" 5878 ENSG00000108774.14 RAB5C 17 TBC/RABGAPs; Neutrophil degranulation; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation Endocytosis; Amoebiasis; Tuberculosis; Phagosome; Vasopressin-regulated water reabsorption; Ras signaling pathway 0 High O75448 Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1 0 7.025 2 1 1 1 989 110.2 6.95 1 1 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;receptor activity Pf11277 9862 ENSG00000008838.19 MED24 17 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 Medium Q9NRF9 DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1 0.022 1.563 7 1 1 1 147 16.8 4.74 1 1 624345.75 1 cell organization and biogenesis;cellular homeostasis;metabolic process nucleus catalytic activity;DNA binding;protein binding Pf00808 54107 ENSG00000148229.12 POLE3 9 Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Activation of the pre-replicative complex; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; M/G1 Transition; Termination of translesion DNA synthesis; Recognition of DNA damage by PCNA-containing replication complex; DNA replication initiation; Dual incision in TC-NER; Telomere C-strand synthesis initiation; PCNA-Dependent Long Patch Base Excision Repair DNA replication; Purine metabolism; Base excision repair; HTLV-I infection; Nucleotide excision repair; Metabolic pathways; Pyrimidine metabolism 0 High P52746 Zinc finger protein 142 OS=Homo sapiens OX=9606 GN=ZNF142 PE=1 SV=4 0 5.072 1 1 1 1 1687 187.8 7.91 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 7701 ENSG00000115568.15 ZNF142 2 0 Medium Q0P651 Protein ABHD18 OS=Homo sapiens OX=9606 GN=ABHD18 PE=2 SV=1 0.048 1.118 1 1 1 1 414 46.9 9.28 1 1 2109214.5 286092.5938 1 1 extracellular Pf09752 80167 ENSG00000164074.14 C4orf29; ABHD18 4 0 Medium P42771 Cyclin-dependent kinase inhibitor 2A OS=Homo sapiens OX=9606 GN=CDKN2A PE=1 SV=2 0.032 1.397 11 1 1 1 156 16.5 5.81 1 1 8843874 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;protein binding;RNA binding "Pf12796, Pf13637, Pf13857" 1029 ENSG00000147889.17 CDKN2A 9 Cyclin D associated events in G1; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence Viral carcinogenesis; Pancreatic cancer; MicroRNAs in cancer; Chronic myeloid leukemia; Non-small cell lung cancer; Pathways in cancer; Glioma; Melanoma; HTLV-I infection; p53 signaling pathway; Bladder cancer; Cell cycle; Endocrine resistance; Platinum drug resistance 0 High Q96EV2 RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3 0 5.615 2 1 1 1 1170 129.9 6.93 1 1 RNA binding Pf14259 155435 ENSG00000184863.10 RBM33 7 0 Low Q8TCU4 Alstrom syndrome protein 1 OS=Homo sapiens OX=9606 GN=ALMS1 PE=1 SV=4 0.078 0.857 0 1 1 1 4168 460.8 6.28 1 1 11860499 1 0 High Q9H8H0 Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1 0.001 3.364 2 1 1 1 719 81.1 6.07 1 1 metabolic process;regulation of biological process nucleus protein binding;RNA binding Pf08168 25926 ENSG00000130935.9 NOL11 17 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 Medium P55268 Laminin subunit beta-2 OS=Homo sapiens OX=9606 GN=LAMB2 PE=1 SV=2 0.019 1.618 1 1 1 1 1798 195.9 6.52 1 1 1691173.625 247156.1563 1 1 cell growth;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;extracellular;Golgi;organelle lumen catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity "Pf00053, Pf00055, Pf00430, Pf00769, Pf01576, Pf02050, Pf02841, Pf04111, Pf06008, Pf09831, Pf12128, Pf12795, Pf13514, Pf13851, Pf13868, Pf15070, Pf15558" 3913 ENSG00000172037.13 LAMB2 3 ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions Amoebiasis; Pathways in cancer; Toxoplasmosis; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 Medium P51553 "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" 0.027 1.474 3 1 1 1 393 42.8 8.5 1 1 218021.625 254686.1875 1 1 metabolic process mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding Pf00180 3421 ENSG00000067829.18 IDH3G X Mitochondrial protein import; Metabolism of proteins; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Metabolic pathways 0 High O75027 "ATP-binding cassette sub-family B member 7, mitochondrial OS=Homo sapiens OX=9606 GN=ABCB7 PE=1 SV=2" 0.008 1.94 1 1 1 1 752 82.6 9.33 1 1 612687.75 1 cellular homeostasis;transport membrane;mitochondrion catalytic activity;nucleotide binding;transporter activity "Pf00005, Pf00664, Pf13207, Pf13304" 22 ENSG00000131269.15 ABCB7 X Cytosolic iron-sulfur cluster assembly; Mitochondrial ABC transporters ABC transporters 0 Medium Q86US8 Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2 0.011 1.839 1 1 1 1 1419 160.4 7.05 1 1 1019918.625 4993283.5 2514515.25 1 1 1 metabolic process;regulation of biological process;transport chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf10373, Pf10374, Pf13638" 23293 ENSG00000070366.13 SMG6 17 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway 0 High Q9Y314 Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1 0 5.792 9 1 1 1 301 33.2 8.82 1 1 2053367.375 1 development;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf04564, Pf04641, Pf11789" 51070 ENSG00000142546.13 NOSIP 19 NOSIP mediated eNOS trafficking 0 Medium Q5VWQ8 Disabled homolog 2-interacting protein OS=Homo sapiens OX=9606 GN=DAB2IP PE=1 SV=2 0.016 1.681 1 1 1 1 1189 131.5 8.72 1 1 10117327 255741.8125 1 1 cell death;cell organization and biogenesis;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding "Pf00168, Pf00169, Pf00616, Pf12004" 153090 ENSG00000136848.16 DAB2IP 9 Regulation of RAS by GAPs; Signaling by RAS mutants; Interleukin-20 family signaling TNF signaling pathway; Apoptosis 0 High Q15011 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1 0.004 2.431 2 1 1 1 391 43.7 5.25 1 1 1031314.625 706313.875 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane protein binding Pf00240 9709 ENSG00000051108.14 HERPUD1 16 ATF4 activates genes Protein processing in endoplasmic reticulum 0 High P61011 Signal recognition particle 54 kDa protein OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1 0.002 2.9 2 1 1 1 504 55.7 8.75 1 1 1417648 1 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00448, Pf01656, Pf02881, Pf02978, Pf03205, Pf09974, Pf13207, Pf13671" 6729 ENSG00000100883.11 SRP54 14 SRP-dependent cotranslational protein targeting to membrane Protein export 0 Medium O94889 Kelch-like protein 18 OS=Homo sapiens OX=9606 GN=KLHL18 PE=1 SV=3 0.044 1.188 1 1 1 1 574 63.6 5.6 1 1 1326616.125 888027.125 1 1 metabolic process catalytic activity;protein binding "Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964" 23276 ENSG00000114648.11 KLHL18 3 0 Medium Q03188 Centromere protein C OS=Homo sapiens OX=9606 GN=CENPC PE=1 SV=2 0.016 1.672 1 1 1 1 943 106.8 9.39 1 1 cell division;cell organization and biogenesis chromosome;cytosol;nucleus DNA binding "Pf07883, Pf11699, Pf15620, Pf15622" 1060 ENSG00000145241.10 CENPC; CENPC1 4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Deposition of new CENPA-containing nucleosomes at the centromere 0 Medium Q9Y3A6 Transmembrane emp24 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TMED5 PE=1 SV=1 0.013 1.777 4 1 1 1 229 26 4.84 1 1 857977.9375 1 cell organization and biogenesis;transport endoplasmic reticulum;Golgi;membrane protein binding Pf01105 50999 ENSG00000117500.12 TMED5 1 WNT ligand biogenesis and trafficking 0 High Q9ULD0 "2-oxoglutarate dehydrogenase-like, mitochondrial OS=Homo sapiens OX=9606 GN=OGDHL PE=1 SV=3" 0.002 2.84 1 1 1 1 1010 114.4 6.65 1 1 metabolic process cytosol;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00676, Pf02779" 55753 ENSG00000197444.9 OGDHL 10 Citrate cycle (TCA cycle); Carbon metabolism; Lysine degradation; Metabolic pathways; Tryptophan metabolism 0 High P07992 DNA excision repair protein ERCC-1 OS=Homo sapiens OX=9606 GN=ERCC1 PE=1 SV=1 0 5.229 7 1 1 1 297 32.5 6.25 1 1 2319029.25 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf00633, Pf03834, Pf12826, Pf14520" 2067 ENSG00000012061.15 ERCC1 19 Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway Fanconi anemia pathway; Nucleotide excision repair; Platinum drug resistance 0 Medium A6NIE6 Putative RRN3-like protein RRN3P2 OS=Homo sapiens OX=9606 GN=RRN3P2 PE=5 SV=3 0.013 1.796 3 1 1 1 340 38 5.17 1 1 Pf05327 653390 RRN3P2 16 0 High Q99417 c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3 0.007 2.013 9 1 1 1 103 12 5.91 1 1 245195.1875 1 metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;nucleus protein binding 26292 ENSG00000214114.8 MYCBP 1 0 High Q5SRE5 Nucleoporin NUP188 homolog OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1 0.003 2.708 1 1 1 1 1749 195.9 6.73 1 1 318173.4375 383105.0938 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport membrane;nucleus structural molecule activity "Pf10487, Pf11894" 23511 ENSG00000095319.14 NUP188 9 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P06744 Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4 0.005 2.082 1 1 1 1 558 63.1 8.32 1 1 1341801.625 356789.9063 255548.375 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;organelle lumen catalytic activity;protein binding Pf00342 2821 ENSG00000105220.14 GPI 19 Glycolysis; Neutrophil degranulation; Gluconeogenesis; TP53 Regulates Metabolic Genes Carbon metabolism; Starch and sucrose metabolism; Pentose phosphate pathway; Glycolysis / Gluconeogenesis; Amino sugar and nucleotide sugar metabolism; Metabolic pathways 0 Low Q8WTP8 Apoptosis-enhancing nuclease OS=Homo sapiens OX=9606 GN=AEN PE=1 SV=2 0.068 0.936 5 1 1 1 325 36.3 9.28 1 1 1255918.5 4700410 1 1 cell death;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;protein binding Pf00929 64782 ENSG00000181026.14 AEN 15 0 High Q9BXF6 Rab11 family-interacting protein 5 OS=Homo sapiens OX=9606 GN=RAB11FIP5 PE=1 SV=1 0.001 3.345 3 1 1 1 653 70.4 9.23 1 1 280808.0625 230577.9844 1 1 regulation of biological process;response to stimulus;transport cytoplasm;endosome;Golgi;membrane;mitochondrion protein binding "Pf00168, Pf09457" 26056 ENSG00000135631.16 RAB11FIP5 2 Endocytosis 0 High Q9H869 YY1-associated protein 1 OS=Homo sapiens OX=9606 GN=YY1AP1 PE=1 SV=2 0.003 2.55 2 1 1 1 796 87.9 7.84 1 1 2494463.25 1065177 1 1 cell differentiation;cell proliferation;metabolic process;regulation of biological process cytoplasm;nucleus protein binding 55249 ENSG00000163374.19 YY1AP1 1 0 High Q7Z7M0 Multiple epidermal growth factor-like domains protein 8 OS=Homo sapiens OX=9606 GN=MEGF8 PE=1 SV=2 0.001 3.697 0 1 1 1 2845 302.9 6.87 1 1 1517661.75 325685.4688 843202.6875 1 1 1 cellular component movement;regulation of biological process;response to stimulus membrane;nucleus metal ion binding;protein binding "Pf00053, Pf00431, Pf07645, Pf12947, Pf13415, Pf13418, Pf13854" 1954 ENSG00000105429.12 MEGF8 19 0 Low Q9Y2H2 Phosphatidylinositide phosphatase SAC2 OS=Homo sapiens OX=9606 GN=INPP5F PE=1 SV=3 0.065 0.98 1 1 1 1 1132 128.3 7.02 1 1 1978506.375 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endosome;membrane catalytic activity;protein binding "Pf02383, Pf12456" 22876 ENSG00000198825.12 INPP5F 10 Synthesis of PIPs at the early endosome membrane 0 High Q5BJF6 Outer dense fiber protein 2 OS=Homo sapiens OX=9606 GN=ODF2 PE=1 SV=1 0.001 4.237 1 1 1 1 829 95.3 7.62 1 1 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf02463, Pf03962, Pf04111, Pf05557, Pf05701, Pf07888, Pf10174, Pf12128, Pf13514" 4957 ENSG00000136811.16 ODF2 9 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 Medium Q8TF47 Zinc finger protein 90 homolog OS=Homo sapiens OX=9606 GN=ZFP90 PE=1 SV=2 0.025 1.516 3 1 1 1 636 73 8.06 1 1 22460346 592898.6875 337022.0313 1 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf13465" 146198 ENSG00000184939.15 ZFP90 16 Generic Transcription Pathway 0 Medium P15622 Zinc finger protein 250 OS=Homo sapiens OX=9606 GN=ZNF250 PE=1 SV=3 0.015 1.76 1 1 1 1 560 63.4 8.28 1 1 1381056.375 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf13465" 58500 ENSG00000196150.13 ZNF250 8 Generic Transcription Pathway 0 High Q9H0U6 "39S ribosomal protein L18, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" 0.002 3.048 5 1 1 1 180 20.6 9.54 1 1 3687431 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00861 29074 ENSG00000112110.9 MRPL18 6 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 Medium P06733 Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2 0.011 1.852 2 1 1 1 434 47.1 7.39 1 1 2938138 577524.4375 250373.9219 1 1 1 metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00113, Pf03952, Pf13378" 2023 ENSG00000074800.13 ENO1 1 Gluconeogenesis; Glycolysis HIF-1 signaling pathway; Carbon metabolism; Glycolysis / Gluconeogenesis; RNA degradation; Biosynthesis of amino acids; Metabolic pathways 0 High Q9P2I0 Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2 0 4.84 2 1 1 1 782 88.4 5.11 1 1 720005.875 193758.4844 1 1 metabolic process;transport membrane;nucleus protein binding;RNA binding "Pf00753, Pf07521, Pf10996, Pf12706, Pf13299" 53981 ENSG00000165934.12 CPSF2 14 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs mRNA surveillance pathway 0 Medium O00507 Probable ubiquitin carboxyl-terminal hydrolase FAF-Y OS=Homo sapiens OX=9606 GN=USP9Y PE=2 SV=2 0.028 1.45 0 1 1 1 2555 290.9 5.86 1 1 1596491.125 241510.9688 116396.3672 1 1 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;protein binding "Pf00443, Pf13423" 8287 ENSG00000114374.12 USP9Y Y 0 Medium P49450 Histone H3-like centromeric protein A OS=Homo sapiens OX=9606 GN=CENPA PE=1 SV=1 0.017 1.651 5 1 1 1 140 16 11.71 1 1 2077249.125 1 cell division;cell organization and biogenesis chromosome;cytosol;nucleus DNA binding;protein binding Pf00125 1058 ENSG00000115163.14 CENPA 2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Deposition of new CENPA-containing nucleosomes at the centromere 0 High Q6RFH5 WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1 0 5.487 4 1 1 1 385 42.4 8.32 1 1 2580245 1 nucleus protein binding Pf00400 54663 ENSG00000133316.15 WDR74 11 0 Medium P51617 Interleukin-1 receptor-associated kinase 1 OS=Homo sapiens OX=9606 GN=IRAK1 PE=1 SV=2 0.022 1.592 3 1 1 1 712 76.5 6.62 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00531, Pf07714" 3654 ENSG00000184216.13 IRAK1 X "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; activated TAK1 mediates p38 MAPK activation; NF-kB is activated and signals survival; Signalling by NGF; p75NTR recruits signalling complexes" Chagas disease (American trypanosomiasis); Epstein-Barr virus infection; Neurotrophin signaling pathway; Leishmaniasis; NF-kappa B signaling pathway; Tuberculosis; Pertussis; Toxoplasmosis; Measles; Toll-like receptor signaling pathway 0 Medium O95299 "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA10 PE=1 SV=1" 0.048 1.137 3 1 1 1 355 40.7 8.48 1 1 398468.0313 685298.5 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;organelle lumen catalytic activity "Pf01712, Pf13207" 4705 ENSG00000281434.2; ENSG00000130414.11 NDUFA10 2; CHR_HG2233_PATCH Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 Medium Q86X27 Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1 0.048 1.117 1 1 1 1 583 65.1 8.73 1 1 18138544 374589.625 1 1 regulation of biological process;response to stimulus cytoplasm;membrane "Pf00169, Pf00617" 55103 ENSG00000116191.17 RALGPS2 1 0 High Q9ULV4 Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1 0.002 2.99 2 1 1 1 474 53.2 7.08 1 1 1200500 475079.8438 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane protein binding "Pf00400, Pf08953, Pf08954" 23603 ENSG00000110880.10 CORO1C 12 0 High Q9UBM7 7-dehydrocholesterol reductase OS=Homo sapiens OX=9606 GN=DHCR7 PE=1 SV=1 0.008 1.967 2 1 1 1 475 54.5 8.7 1 1 144718.9375 738645 809636.375 1 1 1 cell differentiation;metabolic process;regulation of biological process cytosol;endoplasmic reticulum;membrane catalytic activity;nucleotide binding Pf01222 1717 ENSG00000172893.15 DHCR7 11 Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol; Activation of gene expression by SREBF (SREBP) Steroid biosynthesis; Metabolic pathways 0 Medium Q86WA8 "Lon protease homolog 2, peroxisomal OS=Homo sapiens OX=9606 GN=LONP2 PE=1 SV=1" 0.035 1.308 1 1 1 1 852 94.6 7.3 1 1 396586.7813 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00004, Pf01202, Pf02190, Pf05362, Pf07726, Pf07728, Pf13191, Pf13541" 83752 ENSG00000102910.13 LONP2 16 Association of TriC/CCT with target proteins during biosynthesis 0 High P46734 Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2 0.001 3.52 4 1 1 1 347 39.3 7.43 1 1 1320962.875 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 5606 ENSG00000034152.18 MAP2K3 17 Activated TLR4 signalling; activated TAK1 mediates p38 MAPK activation; Oxidative Stress Induced Senescence TNF signaling pathway; Epstein-Barr virus infection; Rap1 signaling pathway; MAPK signaling pathway; Toxoplasmosis; Toll-like receptor signaling pathway; Fc epsilon RI signaling pathway; Inflammatory mediator regulation of TRP channels; Amyotrophic lateral sclerosis (ALS); GnRH signaling pathway; Influenza A 0 Medium P62333 26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1 0.015 1.759 2 1 1 1 389 44.1 7.49 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401" 5706 ENSG00000100519.11 PSMC6 14 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 Medium Q9Y6N1 "Cytochrome c oxidase assembly protein COX11, mitochondrial OS=Homo sapiens OX=9606 GN=COX11 PE=1 SV=3" 0.019 1.621 4 1 1 1 276 31.4 9.06 1 1 287923.5313 335737.625 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding;transporter activity Pf04442 1353 ENSG00000166260.10 COX11 17 TP53 Regulates Metabolic Genes; Respiratory electron transport Oxidative phosphorylation; Metabolic pathways 0 High Q8TEB9 Rhomboid-related protein 4 OS=Homo sapiens OX=9606 GN=RHBDD1 PE=1 SV=1 0.003 2.494 3 1 1 1 315 35.8 8.24 1 1 612370.125 1 cell death;cell differentiation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;mitochondrion catalytic activity;protein binding Pf01694 84236 ENSG00000144468.16 RHBDD1 2 0 High Q9NUM4 Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2 0.004 2.135 5 1 1 1 274 31.1 6.99 1 1 cell organization and biogenesis;regulation of biological process;transport endosome;membrane;vacuole protein binding Pf07092 54664 ENSG00000106460.18 TMEM106B 7 0 Medium Q96FZ2 Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1 0.024 1.541 4 1 1 1 354 40.5 8.15 1 1 515576.2813 1 metabolic process catalytic activity;DNA binding Pf02586 56941 ENSG00000183624.13 C3orf37; HMCES 3 0 Medium P56378 "ATP synthase subunit ATP5MPL, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MPL PE=1 SV=1" 0.038 1.267 12 1 1 1 58 6.7 10.08 1 1 58276804 1030288.313 1578691.875 1 1 1 membrane;mitochondrion Pf08039 9556 ENSG00000156411.9 C14orf2 14 0 Medium Q9BVG3 E3 ubiquitin-protein ligase TRIM62 OS=Homo sapiens OX=9606 GN=TRIM62 PE=1 SV=1 0.03 1.407 1 1 1 1 475 54.2 6.62 1 1 649117.625 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00097, Pf00622, Pf00643, Pf01442, Pf01544, Pf01576, Pf01920, Pf03938, Pf04012, Pf04156, Pf05622, Pf06785, Pf07888, Pf10174, Pf13639, Pf13654, Pf13765, Pf13923, Pf14634, Pf14835, Pf15227, Pf15372, Pf15556" 55223 ENSG00000116525.13 TRIM62 1 Interferon gamma signaling 0 Medium Q9NQX7 Integral membrane protein 2C OS=Homo sapiens OX=9606 GN=ITM2C PE=1 SV=1 0.048 1.122 4 1 1 1 267 30.2 8 1 1 541338.75 1 cell differentiation;regulation of biological process Golgi;membrane;vacuole nucleotide binding;protein binding Pf04089 81618 ENSG00000135916.15 ITM2C 2 0 High Q9H857 5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1 0.003 2.728 2 1 1 1 520 60.7 6.77 1 1 26665.58594 877805.6875 1 1 metabolic process catalytic activity;metal ion binding;receptor activity;signal transducer activity Pf05761 64943 ENSG00000168268.10 NT5DC2 3 0 High Q9Y697 "Cysteine desulfurase, mitochondrial OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" 0.004 2.254 2 1 1 1 457 50.2 8.31 1 1 152873.1406 154633.1563 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00266, Pf01212" 9054 ENSG00000244005.12 NFS1 20 Mitochondrial iron-sulfur cluster biogenesis Sulfur relay system; Thiamine metabolism; Metabolic pathways 0 Medium Q9H8W5 Tripartite motif-containing protein 45 OS=Homo sapiens OX=9606 GN=TRIM45 PE=1 SV=2 0.048 1.122 2 1 1 1 580 64.3 7.91 1 1 5276778.5 1 cytoplasm;cytosol;nucleus metal ion binding;protein binding "Pf00097, Pf00630, Pf00643" 80263 ENSG00000134253.9 TRIM45 1 Interferon gamma signaling 0 High Q06330 Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3 0 5.414 2 1 1 1 500 55.6 7.18 1 1 2421550.25 1 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus catalytic activity;DNA binding;protein binding "Pf09270, Pf09271" 3516 ENSG00000168214.20 RBPJ 4 NOTCH1 Intracellular Domain Regulates Transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; RUNX3 regulates NOTCH signaling; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH2 intracellular domain regulates transcription Viral carcinogenesis; Th1 and Th2 cell differentiation; Epstein-Barr virus infection; Notch signaling pathway 0 Medium Q15166 Serum paraoxonase/lactonase 3 OS=Homo sapiens OX=9606 GN=PON3 PE=1 SV=3 0.026 1.499 2 1 1 1 354 39.6 5.41 1 1 5403.274414 16931548 501392.375 1 1 1 metabolic process;regulation of biological process;response to stimulus extracellular catalytic activity;metal ion binding;protein binding "Pf01731, Pf03088" 5446 ENSG00000105852.10 PON3 7 Synthesis of 5-eicosatetraenoic acids Metabolic pathways 0 High P67870 Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1 0.002 2.824 5 1 1 1 215 24.9 5.55 1 1 684446.4375 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;enzyme regulator activity;metal ion binding;protein binding Pf01214 1460 ENSG00000224774.7; ENSG00000230700.9; ENSG00000206406.9; ENSG00000204435.13; ENSG00000232960.10; ENSG00000224398.7; ENSG00000228875.8 CSNK2B 6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1 WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Neutrophil degranulation; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation Tight junction; Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Wnt signaling pathway; Adherens junction; Measles; Herpes simplex infection 0 High Q8IV63 Inactive serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2 0.001 3.344 2 1 1 1 474 52.8 9.04 1 1 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf10571, Pf12773, Pf13240, Pf13248" 51231 ENSG00000105053.10 VRK3 19 ERKs are inactivated; Activated TLR4 signalling 0 High Q96PQ6 Zinc finger protein 317 OS=Homo sapiens OX=9606 GN=ZNF317 PE=1 SV=2 0.004 2.378 2 1 1 1 595 67.9 8.98 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf01352, Pf13465" 57693 ENSG00000130803.14 ZNF317 19 Generic Transcription Pathway 0 Medium Q8IWU5 Extracellular sulfatase Sulf-2 OS=Homo sapiens OX=9606 GN=SULF2 PE=1 SV=1 0.013 1.777 1 1 1 1 870 100.4 9.17 1 1 495893.3438 462572.625 210825.9844 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding "Pf00884, Pf01676, Pf02995, Pf12548" 55959 ENSG00000196562.14 SULF2 20 0 High O43583 Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2 0 7.578 9 1 1 1 198 22.1 5.3 1 1 2719509.5 1 cell organization and biogenesis;metabolic process ribosome protein binding;RNA binding Pf01253 8562 ENSG00000139726.10 DENR 12 0 High O43709 Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2 0 4.785 6 1 1 1 281 31.9 8.73 1 1 189411888 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;protein binding;RNA binding "Pf01209, Pf08241, Pf08242, Pf12589, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847" 114049 ENSG00000071462.11 WBSCR22; BUD23 7 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q8N0Z8 tRNA pseudouridine synthase-like 1 OS=Homo sapiens OX=9606 GN=PUSL1 PE=1 SV=1 0 5.398 8 1 1 1 303 33.2 9.85 1 1 1086486.125 651994.3125 645704.0625 1 1 1 metabolic process catalytic activity;RNA binding Pf01416 126789 ENSG00000169972.11 PUSL1 1 0 Medium Q8TAT5 Endonuclease 8-like 3 OS=Homo sapiens OX=9606 GN=NEIL3 PE=1 SV=3 0.04 1.23 1 1 1 1 605 67.7 9 1 1 767377.1875 770831.1875 1 1 metabolic process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding "Pf00641, Pf01149, Pf06831, Pf06839" 55247 ENSG00000109674.3 NEIL3 4 Base excision repair 0 High Q15417 Calponin-3 OS=Homo sapiens OX=9606 GN=CNN3 PE=1 SV=1 0.004 2.145 3 1 1 1 329 36.4 6.05 1 1 2600496.25 1 cell differentiation;cell organization and biogenesis;regulation of biological process cytoskeleton;cytosol protein binding "Pf00307, Pf00402" 1266 ENSG00000117519.15 CNN3 1 0 Medium Q9NQS7 Inner centromere protein OS=Homo sapiens OX=9606 GN=INCENP PE=1 SV=3 0.013 1.776 1 1 1 1 918 105.4 9.44 1 1 663778.8125 420426.8438 235061.3125 1 1 1 cell division;cell organization and biogenesis;metabolic process chromosome;cytoplasm;cytoskeleton;cytosol;nucleus protein binding "Pf03941, Pf12178" 3619 ENSG00000149503.12 INCENP 11 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; SUMOylation of DNA replication proteins 0 High Q8N6R0 eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=EEF1AKNMT PE=1 SV=1 0.001 4.279 3 1 1 1 699 78.7 6.73 1 1 1743285.5 6566359 80223.30469 1 1 1 metabolic process catalytic activity;protein binding "Pf01564, Pf08241, Pf12847, Pf13649, Pf13659, Pf13847" 51603 ENSG00000010165.19 METTL13 1 0 Medium P35555 Fibrillin-1 OS=Homo sapiens OX=9606 GN=FBN1 PE=1 SV=4 0.027 1.472 0 1 1 1 2871 312.1 4.93 1 1 635196 271715.2813 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;extracellular;membrane;organelle lumen metal ion binding;protein binding;structural molecule activity "Pf00683, Pf06247, Pf07645, Pf12662, Pf12947, Pf14670" 2200 ENSG00000166147.13 FBN1 15 0 Medium P53634 Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2 0.015 1.757 3 1 1 1 463 51.8 6.99 1 1 467996.5625 538392.1875 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen;vacuole catalytic activity;enzyme regulator activity;protein binding "Pf00112, Pf03051, Pf08773" 1075 ENSG00000109861.15 CTSC 11 Neutrophil degranulation; MHC class II antigen presentation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport Lysosome; Apoptosis 0 High O75648 Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2 0 6.336 4 1 1 1 421 47.7 8.03 1 1 1258230.875 419782.875 1 1 cell organization and biogenesis;metabolic process mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00733, Pf02540, Pf02568, Pf03054" 55687 ENSG00000100416.12 TRMU 22 tRNA modification in the mitochondrion Sulfur relay system 0 High Q9H9A7 RecQ-mediated genome instability protein 1 OS=Homo sapiens OX=9606 GN=RMI1 PE=1 SV=3 0 4.753 2 1 1 1 625 70.1 4.96 1 1 metabolic process;regulation of biological process nucleus nucleotide binding;protein binding "Pf01336, Pf08585" 80010 ENSG00000178966.16 RMI1 9 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi anemia pathway 0 High O14773 Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2 0.003 2.533 3 1 1 1 563 61.2 6.48 1 1 cell differentiation;cell organization and biogenesis;metabolic process mitochondrion;organelle lumen;vacuole catalytic activity;metal ion binding;protein binding Pf09286 1200 ENSG00000166340.15 TPP1 11 XBP1(S) activates chaperone genes Lysosome 0 High Q8WWB7 Glycosylated lysosomal membrane protein OS=Homo sapiens OX=9606 GN=GLMP PE=1 SV=1 0 5.897 5 1 1 1 406 43.8 6.58 1 1 1743142.875 1389445.625 749456.5 1 1 1 regulation of biological process;response to stimulus cytosol;membrane;nucleus;vacuole DNA binding Pf15065 112770 ENSG00000198715.11 C1orf85; GLMP 1 0 High O75462 Cytokine receptor-like factor 1 OS=Homo sapiens OX=9606 GN=CRLF1 PE=1 SV=1 0.002 2.947 4 1 1 1 422 46.3 9.11 1 1 480955.375 338390.5 1 1 regulation of biological process;response to stimulus cytosol;extracellular protein binding "Pf00041, Pf09067, Pf09240" 9244 ENSG00000006016.10 CRLF1 19 IL-6-type cytokine receptor ligand interactions; Interleukin-12 family signaling 0 High Q7Z7H8 "39S ribosomal protein L10, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL10 PE=1 SV=3" 0 6.591 6 1 1 1 261 29.3 9.58 1 1 1049297.125 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00466 124995 ENSG00000159111.12 MRPL10 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9ULG6 Cell cycle progression protein 1 OS=Homo sapiens OX=9606 GN=CCPG1 PE=1 SV=3 0.004 2.272 2 1 1 1 757 87.3 5.95 1 1 244517.2344 178943.4688 637913.375 1 1 1 regulation of biological process membrane protein binding 9236 ENSG00000260916.7 CCPG1 15 0 Medium A6NCI8 Uncharacterized protein C2orf78 OS=Homo sapiens OX=9606 GN=C2ORF78 PE=2 SV=3 0.049 1.114 1 1 1 1 922 100.1 9.03 1 1 1444828.5 1910880.75 1022673.188 1 1 1 Pf15442 388960 ENSG00000187833.7 C2orf78 2 0 High P05423 DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2 0.004 2.261 2 1 1 1 398 44.4 6.98 1 1 708678.75 3173.763184 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding Pf05132 661 ENSG00000168495.12 POLR3D 8 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 Medium P49760 Dual specificity protein kinase CLK2 OS=Homo sapiens OX=9606 GN=CLK2 PE=1 SV=1 0.05 1.108 2 1 1 1 499 60.1 9.66 1 1 359557.0938 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1196 ENSG00000261893.5; ENSG00000176444.18 CLK2 1; CHR_HSCHR1_2_CTG31 0 Low Q9P0Z9 Peroxisomal sarcosine oxidase OS=Homo sapiens OX=9606 GN=PIPOX PE=1 SV=2 0.06 1.024 2 1 1 1 390 44 8.41 1 1 metabolic process organelle lumen catalytic activity;protein binding "Pf00890, Pf01266, Pf13450" 51268 ENSG00000179761.11 PIPOX 17 Lysine catabolism "Peroxisome; Lysine degradation; Glycine, serine and threonine metabolism; Metabolic pathways" 0 High Q6IQ21 Zinc finger protein 770 OS=Homo sapiens OX=9606 GN=ZNF770 PE=1 SV=1 0 7.15 2 1 1 1 691 80 9.55 1 1 1753623.375 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding Pf13465 54989 ENSG00000198146.4 ZNF770 15 Generic Transcription Pathway 0 Medium O14828 Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3 0.03 1.42 5 1 1 1 347 38.3 7.64 1 1 8142.111816 1087291.125 438034.5625 181707.9844 1 1 1 1 transport membrane protein binding Pf04144 10067 ENSG00000116521.10; ENSG00000263290.5 SCAMP3 1; CHR_HSCHR1_2_CTG31 0 Low Q8WZ42 Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4 0.069 0.93 0 1 1 1 34350 3813.7 6.35 1 1 1860823.875 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity "Pf00041, Pf00047, Pf00069, Pf02818, Pf07679, Pf07686, Pf07714, Pf09042, Pf10446, Pf13895, Pf13927" 7273 ENSG00000155657.26 TTN 2 Platelet degranulation ; Striated Muscle Contraction Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM) 0 High O94952 F-box only protein 21 OS=Homo sapiens OX=9606 GN=FBXO21 PE=2 SV=2 0.001 3.292 4 1 1 1 628 72.2 6.09 1 1 1103983.625 1 metabolic process cytosol catalytic activity;DNA binding;protein binding "Pf08755, Pf12937, Pf13369" 23014 ENSG00000135108.14 FBXO21 12 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q8NF37 Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2 0.003 2.537 4 1 1 1 534 59.1 6.02 1 1 metabolic process;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding "Pf01553, Pf13833" 79888 ENSG00000153395.9 LPCAT1 5 Synthesis of PA; Synthesis of PC; Acyl chain remodelling of PG; Neutrophil degranulation; Acyl chain remodelling of PC Ether lipid metabolism; Glycerophospholipid metabolism; Metabolic pathways 0 Medium Q6PI48 "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" 0.015 1.75 1 1 1 1 645 73.5 8.02 1 1 312599.25 1 metabolic process cytoplasm;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf00587, Pf01336, Pf02938" 55157 ENSG00000117593.9 DARS2 1 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High Q96SK2 Transmembrane protein 209 OS=Homo sapiens OX=9606 GN=TMEM209 PE=1 SV=2 0.003 2.735 4 1 1 1 561 62.9 8.63 1 1 membrane Pf09786 84928 ENSG00000146842.16 TMEM209 7 0 High P30041 Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3 0.002 2.884 4 1 1 1 224 25 6.38 1 1 905415.1875 427929.0625 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;vacuole antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 9588 ENSG00000117592.8 PRDX6 1 Neutrophil degranulation; Detoxification of Reactive Oxygen Species Metabolic pathways 0 High P35443 Thrombospondin-4 OS=Homo sapiens OX=9606 GN=THBS4 PE=1 SV=2 0.004 2.135 1 1 1 1 961 105.8 4.68 1 1 738468.8125 262823.9063 242019.5781 1 1 1 cellular component movement;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular metal ion binding;protein binding "Pf02412, Pf05735, Pf07645, Pf11598, Pf12947" 7060 ENSG00000113296.14 THBS4 5 Signaling by PDGF Phagosome; Focal adhesion; Malaria; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q9Y6A4 Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1 0.005 2.096 4 1 1 1 193 22.8 9.76 1 1 3071618.75 1 cell organization and biogenesis;development;metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus protein binding;RNA binding Pf05018 29105 ENSG00000070761.7 C16orf80; CFAP20 16 0 High Q9BRR6 ADP-dependent glucokinase OS=Homo sapiens OX=9606 GN=ADPGK PE=1 SV=1 0.007 1.976 3 1 1 1 497 54.1 6.2 1 1 283359.4688 1 metabolic process endoplasmic reticulum;extracellular;membrane catalytic activity;metal ion binding Pf04587 83440 ADPGK 15 Glycolysis Carbon metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways 0 Medium O60831 PRA1 family protein 2 OS=Homo sapiens OX=9606 GN=PRAF2 PE=1 SV=1 0.029 1.44 6 1 1 1 178 19.2 9.19 1 1 382857.8438 396968.7813 1 1 transport endosome;membrane Pf03208 11230 ENSG00000243279.3 PRAF2 X 0 High Q9H6P5 Threonine aspartase 1 OS=Homo sapiens OX=9606 GN=TASP1 PE=1 SV=1 0.007 1.976 2 1 1 1 420 44.4 7.75 1 1 38983.63281 747757.875 1 1 metabolic process;regulation of biological process catalytic activity;protein binding Pf01112 55617 ENSG00000089123.15 TASP1 20 0 High Q6P1X5 Transcription initiation factor TFIID subunit 2 OS=Homo sapiens OX=9606 GN=TAF2 PE=1 SV=3 0.009 1.899 1 1 1 1 1199 136.9 8.19 1 1 1510335 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf01433 6873 ENSG00000064313.11 TAF2 8 RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape Basal transcription factors 0 Medium Q9H582 Zinc finger protein 644 OS=Homo sapiens OX=9606 GN=ZNF644 PE=1 SV=2 0.027 1.48 1 1 1 1 1327 149.5 8.16 1 1 6946404.5 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding 84146 ENSG00000122482.20 ZNF644 1 0 Medium Q0IIM8 TBC1 domain family member 8B OS=Homo sapiens OX=9606 GN=TBC1D8B PE=1 SV=2 0.025 1.517 1 1 1 1 1120 128.6 5.95 1 1 236091.4063 2198618 1262617.125 581726.5625 1 1 1 1 regulation of biological process;transport enzyme regulator activity;metal ion binding;protein binding "Pf00566, Pf02893" 54885 ENSG00000133138.19 TBC1D8B X Golgi Associated Vesicle Biogenesis 0 Medium Q7Z6J6 FERM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=FRMD5 PE=1 SV=1 0.047 1.142 1 1 1 1 570 65 8.35 1 1 626230.75 1 cell organization and biogenesis;regulation of biological process cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf08736, Pf09379, Pf09380" 84978 ENSG00000171877.20 FRMD5 15 0 Medium Q5T1A1 DC-STAMP domain-containing protein 2 OS=Homo sapiens OX=9606 GN=DCST2 PE=2 SV=2 0.037 1.293 1 1 1 1 773 86.2 8.16 1 1 35458772 1 membrane Pf07782 127579 ENSG00000163354.14 DCST2 1 0 High Q15910 Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2 0 4.585 3 1 1 1 746 85.3 7.02 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf00856, Pf11616" 2146 ENSG00000106462.10 EZH2 7 Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence Lysine degradation; MicroRNAs in cancer 0 High Q96MF7 E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2 0.001 3.173 5 1 1 1 247 27.9 7.74 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;metal ion binding;protein binding "Pf11789, Pf13445" 286053 ENSG00000156831.7 NSMCE2 8 SUMOylation of DNA damage response and repair proteins 0 High Q6UW63 Protein O-glucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POGLUT2 PE=1 SV=1 0.004 2.389 1 1 1 1 502 58 7.71 1 1 410637.0625 1 metabolic process endoplasmic reticulum;organelle lumen catalytic activity;protein binding "Pf00630, Pf05686, Pf13524" 79070 ENSG00000134901.12 KDELC1 13 0 Medium P09884 DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2 0.025 1.521 0 1 1 1 1462 165.8 5.85 1 1 406897.4063 165215.2031 1 1 cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00136, Pf03104, Pf08996, Pf12254" 5422 ENSG00000101868.10 POLA1 X Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching; M/G1 Transition; DNA replication initiation; Activation of E2F1 target genes at G1/S; Polymerase switching on the C-strand of the telomere; Removal of the Flap Intermediate; Telomere C-strand synthesis initiation DNA replication; Purine metabolism; Metabolic pathways; Pyrimidine metabolism 0 High Q9H2G4 Testis-specific Y-encoded-like protein 2 OS=Homo sapiens OX=9606 GN=TSPYL2 PE=1 SV=1 0.001 4.175 2 1 1 1 693 79.4 4.58 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding Pf00956 64061 ENSG00000184205.14 TSPYL2 X XBP1(S) activates chaperone genes 0 High P21266 Glutathione S-transferase Mu 3 OS=Homo sapiens OX=9606 GN=GSTM3 PE=1 SV=3 0.004 2.182 5 1 1 1 225 26.5 5.54 1 1 339474.5313 2370032.75 2225986 3462498.75 1 1 1 1 metabolic process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00043, Pf02798, Pf14497" 2947 ENSG00000134202.10 GSTM3 1 Glutathione conjugation Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Platinum drug resistance 0 High Q14145 Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2 0.001 3.549 2 1 1 1 624 69.6 6.44 1 1 1847205.875 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus catalytic activity;protein binding "Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964" 9817 ENSG00000079999.13 KEAP1 19 Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 High O75190 DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2 0.001 4.062 5 1 1 1 326 36.1 9.16 1 1 1036031.5 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;enzyme regulator activity;protein binding Pf00226 10049 ENSG00000105993.14 DNAJB6 7 Regulation of HSF1-mediated heat shock response 0 Medium Q8IVC4 Zinc finger protein 584 OS=Homo sapiens OX=9606 GN=ZNF584 PE=2 SV=1 0.028 1.464 3 1 1 1 421 48.2 8.76 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 201514 ENSG00000171574.17 ZNF584 19 Generic Transcription Pathway 0 Medium Q00403 Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1 0.046 1.155 5 1 1 1 316 34.8 8.35 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00382, Pf08271" 2959 ENSG00000137947.11 GTF2B 1 RNA polymerase II transcribes snRNA genes; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape Viral carcinogenesis; Basal transcription factors; Epstein-Barr virus infection 0 Medium Q8TDW7 Protocadherin Fat 3 OS=Homo sapiens OX=9606 GN=FAT3 PE=2 SV=3 0.014 1.772 0 1 1 1 4557 501.7 4.87 1 1 1607998.75 1 0 High Q12962 Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1 0 4.523 6 1 1 1 218 21.7 6.57 1 1 2237125.5 1 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;DNA binding;protein binding Pf03540 6881 ENSG00000166337.9 TAF10 11 Ub-specific processing proteases; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; HATs acetylate histones; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Pre-transcription Events; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II HIV Promoter Escape Basal transcription factors; Herpes simplex infection 0 Medium Q6IN84 "rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1" 0.022 1.567 2 1 1 1 353 38.6 7.94 1 1 304166.125 276803328 1104534.375 1 1 1 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding "Pf00588, Pf08032" 79922 ENSG00000274853.2; ENSG00000278619.4 MRM1 17; CHR_HSCHR17_7_CTG4 rRNA modification in the mitochondrion 0 Medium Q01650 Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2 0.025 1.53 4 1 1 1 507 55 7.72 1 1 416027.125 493266.6875 1 1 cell differentiation;cellular component movement;development;metabolic process;transport cytoplasm;cytosol;membrane protein binding;transporter activity "Pf00324, Pf13520" 8140 ENSG00000103257.8 SLC7A5 16 Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane Central carbon metabolism in cancer; mTOR signaling pathway 0 High P11171 Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4 0 4.992 2 1 1 1 864 97 5.58 1 1 3189701 10699669 1 1 cell division;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" 2035 ENSG00000159023.19 EPB41 1 Neurexins and neuroligins Tight junction 0 Medium Q8TCS8 "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" 0.047 1.163 1 1 1 1 783 85.9 7.77 1 1 342107.4688 4276959 2740.257324 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome catalytic activity;protein binding;RNA binding "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" 87178 ENSG00000138035.14 PNPT1 2 Purine metabolism; RNA degradation; Pyrimidine metabolism 0 Medium P83111 "Serine beta-lactamase-like protein LACTB, mitochondrial OS=Homo sapiens OX=9606 GN=LACTB PE=1 SV=2" 0.012 1.824 2 1 1 1 547 60.7 8.53 1 1 330788.6875 1 metabolic process;regulation of biological process cytosol;mitochondrion catalytic activity;protein binding Pf00144 114294 ENSG00000103642.11 LACTB 15 0 Low Q96MH6 Transmembrane protein 68 OS=Homo sapiens OX=9606 GN=TMEM68 PE=2 SV=2 0.072 0.897 6 1 1 1 324 37.4 7.85 1 1 183453.125 47648528 353108.9063 1 1 1 metabolic process membrane catalytic activity "Pf01553, Pf03982" 137695 ENSG00000167904.14 TMEM68 8 0 High Q14197 "Peptidyl-tRNA hydrolase ICT1, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" 0.006 2.037 6 1 1 1 206 23.6 10.07 1 1 cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion;organelle lumen;ribosome catalytic activity;RNA binding Pf00472 3396 ENSG00000167862.9 ICT1; MRPL58 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q5VSG8 "Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Homo sapiens OX=9606 GN=MANEAL PE=2 SV=1" 0.008 1.96 2 1 1 1 457 51.3 6.98 1 1 4832765 1042160 1 1 Golgi;membrane catalytic activity 149175 ENSG00000185090.14 MANEAL 1 0 High O43889 Cyclic AMP-responsive element-binding protein 3 OS=Homo sapiens OX=9606 GN=CREB3 PE=1 SV=2 0.001 3.81 3 1 1 1 371 41.4 4.91 1 1 324652.9688 597189.6875 1 1 0 High Q9Y287 Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1 0.001 3.802 4 1 1 1 266 30.3 5.14 1 1 1159661.625 400079.8125 353532.875 1 1 1 metabolic process;regulation of biological process endosome;extracellular;Golgi;membrane nucleotide binding;protein binding Pf04089 9445 ENSG00000136156.12 ITM2B 13 Amyloid fiber formation 0 Medium Q9UBQ5 Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1 0.015 1.694 5 1 1 1 218 25 4.93 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf03399, Pf10075" 27335 ENSG00000282986.1; ENSG00000178982.9 EIF3K 19; CHR_HG26_PATCH "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" 0 Medium Q86W56 Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1 0.013 1.785 1 1 1 1 976 111 6.43 1 1 metabolic process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf05028 8505; 670 ENSG00000227345.8 PARG; BPHL 10; 6 POLB-Dependent Long Patch Base Excision Repair 0 Low Q70JA7 Chondroitin sulfate synthase 3 OS=Homo sapiens OX=9606 GN=CHSY3 PE=2 SV=3 0.066 0.967 1 1 1 1 882 100.2 8.75 1 1 4924487 1 metabolic process Golgi;membrane catalytic activity;metal ion binding "Pf02434, Pf02709, Pf05679, Pf10111" 337876 ENSG00000198108.3 CHSY3 5 Chondroitin sulfate biosynthesis Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 Medium P49419 Alpha-aminoadipic semialdehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH7A1 PE=1 SV=5 0.038 1.288 2 1 1 1 539 58.5 7.99 1 1 363166.6563 295838.4063 1 1 metabolic process cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf00171 501 ENSG00000164904.17 ALDH7A1 5 Lysine catabolism; Choline catabolism "Fatty acid degradation; Lysine biosynthesis; Ascorbate and aldarate metabolism; Lysine degradation; Glycine, serine and threonine metabolism; Histidine metabolism; beta-Alanine metabolism; Pyruvate metabolism; Glycerolipid metabolism; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways; Tryptophan metabolism; Arginine and proline metabolism; Valine, leucine and isoleucine degradation" 0 High P28066 Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3 0.001 4.102 8 1 1 1 241 26.4 4.79 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome catalytic activity;nucleotide binding;protein binding "Pf00227, Pf10584" 5686 ENSG00000143106.12 PSMA5 1 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 Medium Q5HYJ3 Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3 0.045 1.18 3 1 1 1 339 38.7 9.25 1 1 226348.9844 1482380 789049.9375 615809.1875 1 1 1 1 nucleus protein binding 143684 ENSG00000077458.12 FAM76B 11 0 High O14657 Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2 0.001 3.903 4 1 1 1 336 38 8.54 1 1 1035785.125 1 cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf06309, Pf07724" 27348 ENSG00000136816.15 TOR1B 9 Cargo recognition for clathrin-mediated endocytosis 0 Low Q8IXS0 Protein FAM217A OS=Homo sapiens OX=9606 GN=FAM217A PE=2 SV=2 0.05 1.105 1 1 1 1 508 57.4 8.44 1 1 885426.8125 877031.5625 1 1 Pf15344 222826 ENSG00000145975.14 FAM217A 6 0 High Q9H019 Mitochondrial fission regulator 1-like OS=Homo sapiens OX=9606 GN=MTFR1L PE=1 SV=2 0.005 2.083 4 1 1 1 292 31.9 6.1 1 1 274589.5625 1 cell organization and biogenesis;metabolic process mitochondrion protein binding Pf05308 56181 ENSG00000117640.17 FAM54B; MTFR1L 1 0 Medium Q5H9R7 Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2 0.028 1.45 1 1 1 1 873 97.6 4.6 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding Pf04499 55291 ENSG00000110075.14 PPP6R3 11 COPII (Coat Protein 2) Mediated Vesicle Transport 0 High O60894 Receptor activity-modifying protein 1 OS=Homo sapiens OX=9606 GN=RAMP1 PE=1 SV=1 0.004 2.396 8 1 1 1 148 17 8.21 1 1 342837.5313 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;membrane protein binding;receptor activity;signal transducer activity;transporter activity Pf04901 10267 ENSG00000132329.10 RAMP1 2 G alpha (s) signalling events; Calcitonin-like ligand receptors Vascular smooth muscle contraction 0 High Q5JWF2 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2 0.001 3.992 3 1 1 1 1037 111 5.03 1 1 360056.4063 1 metabolic process;regulation of biological process;response to stimulus cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503, Pf08477" 2778 ENSG00000087460.24 GNAS 20 G alpha (z) signalling events; Prostacyclin signalling through prostacyclin receptor; PKA activation in glucagon signalling; G alpha (s) signalling events; Glucagon-type ligand receptors; G alpha (i) signalling events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins 0 Medium P49755 Transmembrane emp24 domain-containing protein 10 OS=Homo sapiens OX=9606 GN=TMED10 PE=1 SV=2 0.011 1.83 12 1 1 1 219 25 7.44 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;Golgi;membrane protein binding Pf01105 10972 ENSG00000170348.8 TMED10 14 COPI-dependent Golgi-to-ER retrograde traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport 0 High O75486 Transcription initiation protein SPT3 homolog OS=Homo sapiens OX=9606 GN=SUPT3H PE=1 SV=3 0 4.971 4 1 1 1 317 35.8 6.87 1 1 981499.8125 1 0 Medium O60306 RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4 0.028 1.456 1 1 1 1 1485 171.2 6.37 1 1 1417431.5 1 metabolic process;response to stimulus membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf04851, Pf13086, Pf13087, Pf13245, Pf13538" 9716 ENSG00000021776.10 AQR 15 Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER Spliceosome 0 Medium P20700 Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2 0.013 1.791 2 1 1 1 586 66.4 5.16 1 1 389260.75 2002731 399382.625 1 1 1 regulation of biological process;response to stimulus membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf00932, Pf01576, Pf07888, Pf09726, Pf09731, Pf10186, Pf12128" 4001 ENSG00000113368.11 LMNB1 5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Breakdown of the nuclear lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Meiotic synapsis; Depolymerisation of the Nuclear Lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Interleukin-12 family signaling Apoptosis 0 Low P49137 MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1 0.061 1.022 3 1 1 1 400 45.5 8.68 1 1 464165.6875 33299526 3212.590088 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf07714, Pf14531" 9261 ENSG00000162889.10 MAPKAPK2 1 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Activated TLR4 signalling; activated TAK1 mediates p38 MAPK activation; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; CREB phosphorylation; Regulation of HSF1-mediated heat shock response; p38MAPK events; VEGFA-VEGFR2 Pathway; Synthesis of Leukotrienes (LT) and Eoxins (EX); Oxidative Stress Induced Senescence" Viral carcinogenesis; Neurotrophin signaling pathway; VEGF signaling pathway; MAPK signaling pathway 0 Medium Q96IZ7 Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1 0.017 1.65 3 1 1 1 334 38.7 11.08 1 1 779522.375 676543.5 1 1 metabolic process;response to stimulus;transport cytoplasm;nucleus protein binding 51319 ENSG00000174891.12 RSRC1 3 0 Medium Q86SF2 N-acetylgalactosaminyltransferase 7 OS=Homo sapiens OX=9606 GN=GALNT7 PE=1 SV=1 0.037 1.296 2 1 1 1 657 75.3 7.11 1 1 588783.9375 1 metabolic process Golgi;membrane catalytic activity;metal ion binding "Pf00535, Pf00652, Pf02709, Pf10111" 51809 ENSG00000109586.11 GALNT7 4 O-linked glycosylation of mucins Mucin type O-glycan biosynthesis; Metabolic pathways 0 High P00450 Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1 0.002 3.076 1 1 1 1 1065 122.1 5.72 1 1 529843.125 333168.7188 1 1 cellular homeostasis;metabolic process;transport extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00394, Pf07731, Pf07732" 1356 CP 3 Metal ion SLC transporters; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Iron uptake and transport; Defective CP causes aceruloplasminemia (ACERULOP) Porphyrin and chlorophyll metabolism 0 High Q92729 Receptor-type tyrosine-protein phosphatase U OS=Homo sapiens OX=9606 GN=PTPRU PE=1 SV=2 0.002 3.081 1 1 1 1 1446 162.3 6.92 1 1 444274.9688 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;protein binding;receptor activity;signal transducer activity "Pf00041, Pf00102, Pf00629, Pf14566" 10076 ENSG00000060656.19 PTPRU 1 Signaling by SCF-KIT 0 Medium Q9Y4C4 Malignant fibrous histiocytoma-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MFHAS1 PE=1 SV=2 0.048 1.123 1 1 1 1 1052 116.9 7.88 1 1 437264.9063 1 regulation of biological process;response to stimulus membrane protein binding "Pf12799, Pf13855" 9258 ENSG00000147324.10 MFHAS1 8 0 High O75822 Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2 0.001 4.254 5 1 1 1 258 29 4.83 1 1 516696.9375 302101.6563 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol protein binding;RNA binding Pf08597 8669 ENSG00000104131.12 EIF3J 15 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 Medium P28072 Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4 0.015 1.728 5 1 1 1 239 25.3 4.92 1 1 5296644 678345.9375 3105632.75 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;protein binding Pf00227 5694 ENSG00000142507.9 PSMB6 17 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q96AQ6 Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Homo sapiens OX=9606 GN=PBXIP1 PE=1 SV=1 0.003 2.702 1 1 1 1 731 80.6 5.33 1 1 474009.4688 340971.0625 1 1 cell differentiation;development;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus protein binding 57326 ENSG00000163346.16 PBXIP1 1 0 Medium Q6UW56 All-trans retinoic acid-induced differentiation factor OS=Homo sapiens OX=9606 GN=ATRAID PE=1 SV=2 0.025 1.534 3 1 1 1 229 24.7 7.25 1 1 29869510 615995.4375 1 1 cell differentiation;regulation of biological process membrane;nucleus protein binding 51374 ENSG00000138085.16 ATRAID 2 0 High Q96EE3 Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3 0 4.92 4 1 1 1 360 39.6 8.09 1 1 cell communication;cell division;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytosol;membrane;nucleus;vacuole protein binding Pf00400 81929 ENSG00000085415.15 SEH1L 18 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins mTOR signaling pathway; RNA transport 0 High Q96IZ5 RNA-binding protein 41 OS=Homo sapiens OX=9606 GN=RBM41 PE=1 SV=2 0.001 3.502 7 1 1 1 413 47.1 8.7 1 1 metabolic process spliceosomal complex protein binding;RNA binding "Pf00076, Pf14259" 55285 ENSG00000089682.16 RBM41 X 0 High Q9H5V9 UPF0428 protein CXorf56 OS=Homo sapiens OX=9606 GN=CXORF56 PE=1 SV=1 0 5.032 6 1 1 1 222 25.6 8.73 1 1 2572592.25 57979.79688 1 1 63932 CXorf56 X 0 Low Q86UE8 Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2 0.063 0.997 1 1 1 1 772 87.6 8.41 1 1 2926247.75 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 11011 ENSG00000146872.17 TLK2 17 0 Medium Q9P0J6 "39S ribosomal protein L36, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL36 PE=1 SV=1" 0.026 1.503 6 1 1 1 103 11.8 11.27 1 1 371649.5 5355893 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf00444 64979 ENSG00000171421.12 MRPL36 5 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 Low Q9BYB4 Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2 0.051 1.1 3 1 1 1 327 35.6 7.97 1 1 170739.3906 1 regulation of biological process;response to stimulus cytoplasm protein binding Pf00400 54584 ENSG00000185838.13 GNB1L 22 0 Medium P55083 Microfibril-associated glycoprotein 4 OS=Homo sapiens OX=9606 GN=MFAP4 PE=1 SV=2 0.04 1.218 2 1 1 1 255 28.6 5.63 1 1 634173 1 cell organization and biogenesis;regulation of biological process;response to stimulus extracellular protein binding Pf00147 4239 ENSG00000166482.11 MFAP4 17 Molecules associated with elastic fibres 0 Medium P61077 Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1 0.046 1.173 16 1 1 1 147 16.7 7.8 1 1 256375.1406 137125.4219 1 1 cell death;metabolic process;regulation of biological process;response to stimulus cytosol;endosome;membrane catalytic activity;nucleotide binding;protein binding "Pf00179, Pf14461" 7323 ENSG00000109332.19 UBE2D3 4 "IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Activated TLR4 signalling; Signaling by BMP; E3 ubiquitin ligases ubiquitinate target proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Negative regulators of DDX58/IFIH1 signaling" Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 0 Medium Q16878 Cysteine dioxygenase type 1 OS=Homo sapiens OX=9606 GN=CDO1 PE=1 SV=2 0.015 1.762 4 1 1 1 200 23 6.6 1 1 616611.625 794924.9375 598091.75 1288560.75 1 1 1 1 defense response;metabolic process;response to stimulus;transport cytosol catalytic activity;metal ion binding Pf05995 1036 ENSG00000129596.4 CDO1 5 Degradation of cysteine and homocysteine Taurine and hypotaurine metabolism; Metabolic pathways; Cysteine and methionine metabolism 0 High C9JLW8 Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1 0.001 3.679 11 1 1 1 97 10.9 9.41 1 1 942927.0625 1 regulation of biological process cytoplasm;nucleus protein binding Pf14799 348262 ENSG00000225663.7 FAM195B; MCRIP1 17 0 Medium Q96SM3 Probable carboxypeptidase X1 OS=Homo sapiens OX=9606 GN=CPXM1 PE=2 SV=2 0.048 1.136 1 1 1 1 734 81.6 6.67 1 1 1340657.5 498285.75 1 1 metabolic process extracellular catalytic activity;metal ion binding "Pf00246, Pf00754, Pf13620, Pf13715" 56265 ENSG00000088882.7 CPXM1 20 0 Medium Q9NX70 Mediator of RNA polymerase II transcription subunit 29 OS=Homo sapiens OX=9606 GN=MED29 PE=1 SV=1 0.015 1.762 9 1 1 1 200 21.1 6.29 1 1 1164998.75 348961.1563 1 1 metabolic process;regulation of biological process nucleus protein binding Pf11568 55588 ENSG00000063322.13 MED29 19 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q8NI60 "Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1" 0.003 2.665 2 1 1 1 647 71.9 6.99 1 1 1710229.75 474857.3438 1 1 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding;protein binding Pf03109 56997 ENSG00000163050.16 ADCK3; COQ8A 1 0 High Q8N2K0 Lysophosphatidylserine lipase ABHD12 OS=Homo sapiens OX=9606 GN=ABHD12 PE=1 SV=2 0.003 2.69 4 1 1 1 398 45.1 8.65 1 1 800985.6875 1 metabolic process;response to stimulus cytoplasm;membrane catalytic activity "Pf00326, Pf00561, Pf12695, Pf12697" 26090 ENSG00000100997.18 ABHD12 20 Arachidonate production from DAG; Gastrin-CREB signalling pathway via PKC and MAPK 0 High Q7Z2Z1 Treslin OS=Homo sapiens OX=9606 GN=TICRR PE=1 SV=2 0.004 2.361 0 1 1 1 1910 210.7 8.78 1 1 3051391.5 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding Pf15292 90381 ENSG00000140534.13 TICRR 15 0 High O75446 Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1 0 5.319 5 1 1 1 220 23.3 9.17 1 1 51866.93359 2093767.625 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf13866, Pf13867" 8819 ENSG00000164105.3 SAP30 4 HDACs deacetylate histones; NoRC negatively regulates rRNA expression 0 Medium Q9UL33 Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1 0.015 1.763 9 1 1 1 140 16.1 6.77 1 1 2595777.75 703841.1875 1 1 cell organization and biogenesis;transport cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane protein binding "Pf04099, Pf04628" 51693 ENSG00000167515.10 TRAPPC2L 16 RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport 0 Medium Q9H633 Ribonuclease P protein subunit p21 OS=Homo sapiens OX=9606 GN=RPP21 PE=1 SV=1 0.02 1.61 5 1 1 1 154 17.6 9.45 1 1 metabolic process;response to stimulus nucleus catalytic activity;metal ion binding Pf04032 79897 ENSG00000241370.5; ENSG00000241863.6; ENSG00000239927.6 RPP21 6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1 Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus RNA transport 0 Medium Q07954 Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2 0.015 1.722 0 1 1 1 4544 504.3 5.39 1 1 744809.6875 113929.7969 1 1 cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane;nucleus metal ion binding;protein binding;receptor activity;RNA binding;transporter activity "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670" 4035 ENSG00000123384.13 LRP1 12 Signaling by GPCR; Scavenging of heme from plasma; Retinoid metabolism and transport Malaria; Alzheimer's disease 0 High Q9H5J8 TATA box-binding protein-associated factor RNA polymerase I subunit D OS=Homo sapiens OX=9606 GN=TAF1D PE=1 SV=1 0.003 2.593 5 1 1 1 278 32 8.73 1 1 3907679.75 1 metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf15333 79101 ENSG00000166012.16 TAF1D 11 SIRT1 negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation 0 Medium P57775 F-box/WD repeat-containing protein 4 OS=Homo sapiens OX=9606 GN=FBXW4 PE=1 SV=1 0.048 1.132 3 1 1 1 412 46.3 7.58 1 1 2179505 1 development;metabolic process;regulation of biological process;response to stimulus cytosol catalytic activity;protein binding "Pf00400, Pf12937" 6468 ENSG00000107829.13 FBXW4 10 Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High O00754 Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3 0.001 3.474 2 1 1 1 1011 113.7 7.28 1 1 metabolic process;transport extracellular;organelle lumen;vacuole catalytic activity;metal ion binding "Pf01074, Pf07748, Pf09261" 4125 ENSG00000104774.12 MAN2B1 19 Neutrophil degranulation; Lysosomal oligosaccharide catabolism Lysosome; Other glycan degradation 0 Medium Q9BTE3 Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2 0.046 1.166 3 1 1 1 642 72.9 5.87 1 1 219378.7031 208079.8594 1 1 cell division;cell organization and biogenesis;metabolic process cytosol;membrane;nucleus protein binding "Pf09739, Pf13615" 79892 ENSG00000197771.12 MCMBP 10 0 High Q14919 Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3 0.001 4.245 5 1 1 1 205 22.3 5.17 1 1 1194941.5 561008.5 1 1 metabolic process;regulation of biological process nucleus DNA binding;protein binding "Pf00125, Pf00808" 10589 ENSG00000175550.7 DRAP1 11 Signaling by NODAL; Signaling by Activin 0 Medium Q10469 "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=MGAT2 PE=1 SV=1" 0.013 1.775 2 1 1 1 447 51.5 8.76 1 1 241057.9063 604862.3125 1 1 metabolic process Golgi;membrane catalytic activity Pf05060 4247 ENSG00000168282.5 MGAT2 14 Defective MGAT2 causes MGAT2-CDG (CDG-2a); Reactions specific to the complex N-glycan synthesis pathway N-Glycan biosynthesis; Metabolic pathways 0 Medium Q5BJD5 Transmembrane protein 41B OS=Homo sapiens OX=9606 GN=TMEM41B PE=1 SV=1 0.025 1.52 7 1 1 1 291 32.5 9.58 1 1 membrane Pf09335 440026 ENSG00000166471.10 TMEM41B 11 0 High P42695 Condensin-2 complex subunit D3 OS=Homo sapiens OX=9606 GN=NCAPD3 PE=1 SV=2 0.001 4.281 1 1 1 1 1498 168.8 7.5 1 1 cell division;cell organization and biogenesis;metabolic process membrane;nucleus protein binding "Pf12717, Pf15058" 23310 ENSG00000151503.12 NCAPD3 11 Condensation of Prophase Chromosomes 0 Medium Q9HB07 "UPF0160 protein MYG1, mitochondrial OS=Homo sapiens OX=9606 GN=C12ORF10 PE=1 SV=2" 0.011 1.853 3 1 1 1 376 42.4 6.67 1 1 276385.3125 1 response to stimulus mitochondrion;nucleus Pf03690 60314 ENSG00000139637.13 C12orf10 12 0 High Q562E7 WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2 0.004 2.375 1 1 1 1 1941 211.6 5.58 1 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;Golgi;membrane;mitochondrion;vacuole enzyme regulator activity;protein binding "Pf00400, Pf02138" 124997 ENSG00000167716.18 WDR81 17 0 Medium Q7L0R7 RING finger protein 44 OS=Homo sapiens OX=9606 GN=RNF44 PE=2 SV=1 0.012 1.823 2 1 1 1 432 47.7 6.89 1 1 28840152 490981.7188 1 1 metabolic process catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf13639, Pf13920, Pf13923, Pf14634" 22838 ENSG00000146083.11 RNF44 5 0 High P15586 N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3 0.004 2.312 2 1 1 1 552 62 8.31 1 1 509554.9063 1075274.75 1 1 metabolic process;transport extracellular;organelle lumen;vacuole catalytic activity;metal ion binding;protein binding "Pf00884, Pf01663" 2799 ENSG00000135677.10 GNS 12 Neutrophil degranulation; MPS IIID - Sanfilippo syndrome D; Keratan sulfate degradation; Lysosome Vesicle Biogenesis Lysosome; Glycosaminoglycan degradation; Metabolic pathways 0 Medium Q9H3T3 Semaphorin-6B OS=Homo sapiens OX=9606 GN=SEMA6B PE=1 SV=4 0.039 1.259 3 1 1 1 888 95.2 8.48 1 1 409291.5938 114501896 1850149.75 438996.7813 1 1 1 1 cell differentiation;development membrane protein binding "Pf01403, Pf01437" 10501 ENSG00000167680.15 SEMA6B 19 Axon guidance 0 High Q99942 E3 ubiquitin-protein ligase RNF5 OS=Homo sapiens OX=9606 GN=RNF5 PE=1 SV=1 0.003 2.656 9 1 1 1 180 19.9 6.65 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00097, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" 6048 ENSG00000228405.5; ENSG00000228907.5; ENSG00000183574.12; ENSG00000204308.7; ENSG00000227277.9; ENSG00000225452.5; ENSG00000223767.5 RNF5 6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_APD_CTG1 ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis Protein processing in endoplasmic reticulum 0 Medium Q63HN8 E3 ubiquitin-protein ligase RNF213 OS=Homo sapiens OX=9606 GN=RNF213 PE=1 SV=3 0.02 1.606 0 1 1 1 5207 591 6.48 1 1 6553790 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;metal ion binding;protein binding "Pf00097, Pf13639, Pf13920, Pf13923, Pf15227" 57674 RNF213 17 Antigen processing: Ubiquitination & Proteasome degradation 0 High P18615 Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3 0 4.582 3 1 1 1 380 43.2 9.33 1 1 metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259, Pf14605" 7936 ENSG00000204356.13; ENSG00000206268.11; ENSG00000233801.9; ENSG00000206357.11; ENSG00000231044.10; ENSG00000229363.9 NELFE; RDBP 6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1 HIV elongation arrest and recovery; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the Early Elongation Complex 0 Low Q86TJ5 Zinc finger protein 554 OS=Homo sapiens OX=9606 GN=ZNF554 PE=1 SV=1 0.08 0.84 5 1 1 1 538 60.5 7.61 1 1 3578711.5 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf01352, Pf13465" 115196 ENSG00000172006.11 ZNF554 19 Generic Transcription Pathway 0 Medium Q9P086 Mediator of RNA polymerase II transcription subunit 11 OS=Homo sapiens OX=9606 GN=MED11 PE=1 SV=2 0.015 1.722 9 1 1 1 117 13.1 5.96 1 1 191249.25 657145.625 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf10280 400569 ENSG00000161920.9 MED11 17 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q5JVF3 PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2 0 5.342 3 1 1 1 399 46 8.53 1 1 3302365.5 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport DNA binding;protein binding;RNA binding Pf01399 55795 ENSG00000126226.21 PCID2 13 0 Low Q6VVX0 Vitamin D 25-hydroxylase OS=Homo sapiens OX=9606 GN=CYP2R1 PE=1 SV=1 0.066 0.966 1 1 1 1 501 57.3 7.61 1 1 8661915 84182.11719 1 1 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf00067 120227 ENSG00000186104.10 CYP2R1 11 Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B); Vitamins; Vitamin D (calciferol) metabolism Steroid biosynthesis; Metabolic pathways 0 Medium Q5T9L3 Protein wntless homolog OS=Homo sapiens OX=9606 GN=WLS PE=1 SV=2 0.023 1.558 1 1 1 1 541 62.2 7.36 1 1 2657364 891938.625 1 1 development;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane protein binding;signal transducer activity Pf06664 79971 ENSG00000116729.13 WLS 1 WNT ligand biogenesis and trafficking 0 Medium P09669 Cytochrome c oxidase subunit 6C OS=Homo sapiens OX=9606 GN=COX6C PE=1 SV=2 0.035 1.34 11 1 1 1 75 8.8 10.39 1 1 1062177.375 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02937 1345 ENSG00000164919.10 COX6C 8 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 Medium Q9NVS2 "39S ribosomal protein S18a, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1" 0.022 1.565 8 1 1 1 196 22.2 10.33 1 1 962306.875 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf01084 55168 ENSG00000096080.11 MRPS18A 6 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q13405 "39S ribosomal protein L49, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" 0 4.382 7 1 1 1 166 19.2 9.45 1 1 2139862.75 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;structural molecule activity Pf05046 740 ENSG00000149792.8 MRPL49 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High P08195 4F2 cell-surface antigen heavy chain OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3 0.001 3.265 2 1 1 1 630 68 5.01 1 1 1016264.438 1 cell growth;cellular component movement;metabolic process;response to stimulus;transport cell surface;cytosol;membrane;nucleus catalytic activity;protein binding;RNA binding;transporter activity Pf00128 6520 ENSG00000168003.16 SLC3A2 11 Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane Protein digestion and absorption; mTOR signaling pathway 0 High Q9NXC5 GATOR complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2 0.003 2.523 2 1 1 1 875 98.5 6.73 1 1 399550.4688 5898780.5 1 1 Met-loss+Acetyl [N-Term] cell communication;regulation of biological process;response to stimulus membrane;vacuole protein binding 54468 ENSG00000164654.15 MIOS 7 mTOR signaling pathway 0 High P17029 Zinc finger protein with KRAB and SCAN domains 1 OS=Homo sapiens OX=9606 GN=ZKSCAN1 PE=1 SV=3 0 5.639 3 1 1 1 563 63.6 7.05 1 1 1247450.875 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf02023, Pf13465" 7586 ENSG00000106261.16 ZKSCAN1 7 Generic Transcription Pathway 0 Medium P30533 Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1 0.011 1.848 2 1 1 1 357 41.4 8.78 1 1 19830346 8128107 446706.5938 1 1 1 regulation of biological process;transport cell surface;cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;organelle lumen protein binding "Pf06400, Pf06401" 4043 ENSG00000163956.10 LRPAP1 4 0 High Q9UK61 Protein TASOR OS=Homo sapiens OX=9606 GN=TASOR PE=1 SV=3 0.002 2.832 1 1 1 1 1670 188.9 5.8 1 1 357211.8125 1 metabolic process;regulation of biological process chromosome;nucleus protein binding;RNA binding Pf12509 23272 FAM208A 3 0 High Q9UK32 Ribosomal protein S6 kinase alpha-6 OS=Homo sapiens OX=9606 GN=RPS6KA6 PE=1 SV=1 0.003 2.5 1 1 1 1 745 83.8 6.34 1 1 562236.5625 338117.3438 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding "Pf00069, Pf00433, Pf07714, Pf14531" 27330 ENSG00000072133.10 RPS6KA6 X RSK activation; Recycling pathway of L1 Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; MAPK signaling pathway; Long-term potentiation; mTOR signaling pathway; Oocyte meiosis; Insulin resistance 0 High Q96L15 Ecto-ADP-ribosyltransferase 5 OS=Homo sapiens OX=9606 GN=ART5 PE=2 SV=4 0.001 3.288 4 1 1 1 291 32 8.27 1 1 767354.875 1355643.625 1 1 metabolic process extracellular;membrane catalytic activity Pf01129 116969 ENSG00000167311.13 ART5 11 0 High Q9BUE0 Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1 0.001 3.256 7 1 1 1 208 23.6 6.54 1 1 491537.75 1 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf09637 54797 ENSG00000130772.13 MED18 1 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 Medium Q9Y3C7 Mediator of RNA polymerase II transcription subunit 31 OS=Homo sapiens OX=9606 GN=MED31 PE=1 SV=1 0.015 1.743 5 1 1 1 131 15.8 8.54 1 1 1439976.25 669399.0625 302554.7813 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf05669 51003 ENSG00000108590.10 MED31 17 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 Medium Q9UKF6 Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1 0.047 1.144 2 1 1 1 684 77.4 5.6 1 1 432037.0313 1 metabolic process;transport nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00753, Pf07521, Pf10996, Pf11718, Pf12706, Pf13483" 51692 ENSG00000119203.13 CPSF3 2 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs mRNA surveillance pathway 0 Low O14908 PDZ domain-containing protein GIPC1 OS=Homo sapiens OX=9606 GN=GIPC1 PE=1 SV=2 0.075 0.869 8 1 1 1 333 36 6.28 1 1 cell communication;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane protein binding Pf00595 10755 ENSG00000123159.15 GIPC1 19 0 Medium Q8IY92 Structure-specific endonuclease subunit SLX4 OS=Homo sapiens OX=9606 GN=SLX4 PE=1 SV=3 0.025 1.539 0 1 1 1 1834 199.9 6.06 1 1 193096.25 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;enzyme regulator activity;protein binding "Pf00651, Pf09494" 84464 ENSG00000188827.10 SLX4 16 Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi anemia pathway 0 Medium Q96BY6 Dedicator of cytokinesis protein 10 OS=Homo sapiens OX=9606 GN=DOCK10 PE=1 SV=3 0.035 1.313 1 1 1 1 2186 249.4 7.14 1 1 1206811 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus protein binding "Pf00169, Pf06920, Pf11878, Pf14429" 55619 ENSG00000135905.18 DOCK10 2 Factors involved in megakaryocyte development and platelet production 0 Medium Q3T8J9 GON-4-like protein OS=Homo sapiens OX=9606 GN=GON4L PE=1 SV=1 0.038 1.284 1 1 1 1 2241 248.5 5.01 1 1 105275.7188 1 cell differentiation;metabolic process;regulation of biological process nucleus DNA binding Pf02671 54856 ENSG00000116580.18 GON4L 1 0 High Q7L2H7 Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1 0 8.877 5 1 1 1 374 42.5 5.63 1 1 1658890.5 1 metabolic process cytoplasm;cytosol protein binding;RNA binding Pf01399 10480 ENSG00000149100.12 EIF3M 11 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" 0 High O75694 Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1 0.001 3.174 2 1 1 1 1391 155.1 6.16 1 1 389989.75 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;nucleus protein binding;structural molecule activity;transporter activity "Pf03177, Pf08801" 9631 ENSG00000113569.15 NUP155 5 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q9GZU3 Transmembrane protein 39B OS=Homo sapiens OX=9606 GN=TMEM39B PE=1 SV=1 0.004 2.155 5 1 1 1 492 56.2 9.41 1 1 membrane Pf10271 55116 ENSG00000121775.17 TMEM39B 1 0 High Q9UIG0 Tyrosine-protein kinase BAZ1B OS=Homo sapiens OX=9606 GN=BAZ1B PE=1 SV=2 0.002 2.86 1 1 1 1 1483 170.8 8.48 1 1 592167.125 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00439, Pf00628, Pf10537, Pf15613, Pf15614" 9031 ENSG00000009954.10 BAZ1B 7 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; B-WICH complex positively regulates rRNA expression 0 Medium Q15363 Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1 0.029 1.44 3 1 1 1 201 22.7 5.17 1 1 509032.1563 1 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding Pf01105 10959 ENSG00000086598.10 TMED2 12 COPI-dependent Golgi-to-ER retrograde traffic; Cargo concentration in the ER; Pre-NOTCH Processing in Golgi; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport 0 High Q9H9D4 Zinc finger protein 408 OS=Homo sapiens OX=9606 GN=ZNF408 PE=1 SV=1 0.002 2.948 1 1 1 1 720 78.4 7.24 1 1 138583.5625 785631.5 199139.5 1 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf13465" 79797 ENSG00000175213.2 ZNF408 11 0 High P12755 Ski oncogene OS=Homo sapiens OX=9606 GN=SKI PE=1 SV=1 0.004 2.258 1 1 1 1 728 80 7.62 1 1 2488986 1 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus enzyme regulator activity;metal ion binding;protein binding "Pf02437, Pf08782" 6497 ENSG00000157933.9 SKI 1 Signaling by BMP; Downregulation of SMAD2/3:SMAD4 transcriptional activity 0 Medium Q86UK0 ATP-binding cassette sub-family A member 12 OS=Homo sapiens OX=9606 GN=ABCA12 PE=1 SV=3 0.013 1.792 0 1 1 1 2595 293 7.75 1 1 731916.9375 1543591.625 1509976.25 661422.8125 1 1 1 1 cell differentiation;cell organization and biogenesis;cellular homeostasis;regulation of biological process;transport cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00005, Pf12698, Pf13304" 26154 ENSG00000144452.14 ABCA12 2 ABC transporters in lipid homeostasis; Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B ABC transporters 0 High P05114 Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3 0 5.02 13 1 1 1 100 10.7 9.6 1 1 8251.467773 1877262.375 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding 3150 ENSG00000205581.10 HMGN1 21 Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Gap-filling DNA repair synthesis and ligation in TC-NER Herpes simplex infection 0 High O95365 Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1 0.002 2.814 2 1 1 1 584 61.4 5.19 1 1 cell differentiation;development;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465, Pf13894" 51341 ENSG00000178951.8 ZBTB7A 19 0 High Q16560 U11/U12 small nuclear ribonucleoprotein 35 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP35 PE=1 SV=1 0 5.99 6 1 1 1 246 29.4 9.86 1 1 1327560.875 62062.54688 1 1 metabolic process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 11066 ENSG00000184209.14 SNRNP35 12 mRNA Splicing - Minor Pathway 0 Medium P30048 "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" 0.023 1.553 12 1 1 1 256 27.7 7.78 1 1 cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;mitochondrion;organelle lumen antioxidant activity;catalytic activity;enzyme regulator activity;protein binding "Pf00578, Pf08534, Pf10417, Pf13905" 10935 ENSG00000165672.6 PRDX3 10 Detoxification of Reactive Oxygen Species 0 Medium Q969X5 Endoplasmic reticulum-Golgi intermediate compartment protein 1 OS=Homo sapiens OX=9606 GN=ERGIC1 PE=1 SV=1 0.022 1.593 5 1 1 1 290 32.6 7.06 1 1 768732.375 456765.5625 1 1 transport endoplasmic reticulum;Golgi;membrane protein binding "Pf07970, Pf13850" 57222 ENSG00000113719.15 ERGIC1 5 0 Medium Q16659 Mitogen-activated protein kinase 6 OS=Homo sapiens OX=9606 GN=MAPK6 PE=1 SV=1 0.015 1.708 1 1 1 1 721 82.6 5.03 1 1 812468.125 764513.9375 447973.9375 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf01636, Pf07714, Pf14531" 5597 ENSG00000069956.11 MAPK6 15 MAPK6/MAPK4 signaling 0 Low Q9HBJ7 Ubiquitin carboxyl-terminal hydrolase 29 OS=Homo sapiens OX=9606 GN=USP29 PE=2 SV=1 0.067 0.954 2 1 1 1 922 104.1 5.91 1 1 1738136.25 490398.5625 1 1 metabolic process catalytic activity "Pf00443, Pf13423" 57663 ENSG00000131864.10 USP29 19 0 High Q6P9G9 Zinc finger protein 449 OS=Homo sapiens OX=9606 GN=ZNF449 PE=1 SV=3 0 5.675 6 1 1 1 518 59.9 7.31 1 1 194393.125 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf02023, Pf05443, Pf09723, Pf09845, Pf13465" 203523 ENSG00000173275.12 ZNF449 X 0 High P21796 Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2 0.001 3.379 4 1 1 1 283 30.8 8.54 1 1 1460859.625 1019619.5 1 1 cell communication;cell death;cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf01459 7416 ENSG00000213585.10 VDAC1 5 Mitochondrial calcium ion transport; Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Influenza A; Calcium signaling pathway 0 High P51648 Fatty aldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH3A2 PE=1 SV=1 0.004 2.431 3 1 1 1 485 54.8 7.88 1 1 metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity Pf00171 224 ENSG00000072210.18 ALDH3A2 17 Sphingolipid de novo biosynthesis "Fatty acid degradation; Ascorbate and aldarate metabolism; Lysine degradation; Histidine metabolism; beta-Alanine metabolism; Pyruvate metabolism; Glycerolipid metabolism; Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Metabolic pathways; Tryptophan metabolism; Arginine and proline metabolism; Valine, leucine and isoleucine degradation" 0 High Q8WUY9 DEP domain-containing protein 1B OS=Homo sapiens OX=9606 GN=DEPDC1B PE=1 SV=2 0.001 3.331 2 1 1 1 529 61.7 8.85 1 1 514710.0938 1 cellular component movement;regulation of biological process;response to stimulus cytosol enzyme regulator activity "Pf00610, Pf00620" 55789 ENSG00000035499.12 DEPDC1B 5 Rho GTPase cycle 0 High O43148 mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1 0.004 2.404 4 1 1 1 476 54.8 6.61 1 1 metabolic process nucleus catalytic activity;protein binding;RNA binding Pf03291 8731 ENSG00000101654.17 RNMT 18 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Capping mRNA surveillance pathway 0 High Q9UHV7 Mediator of RNA polymerase II transcription subunit 13 OS=Homo sapiens OX=9606 GN=MED13 PE=1 SV=3 0.003 2.644 0 1 1 1 2174 239.1 5.64 1 1 469325.6875 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity "Pf06333, Pf11597" 9969 ENSG00000108510.9 MED13 17 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High O60508 Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1 0 5.285 4 1 1 1 579 65.5 7.06 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding Pf00400 51362 ENSG00000168438.14 CDC40 6 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome 0 Medium Q7Z4T9 Cilia- and flagella-associated protein 91 OS=Homo sapiens OX=9606 GN=MAATS1 PE=1 SV=3 0.041 1.207 1 1 1 1 767 89.9 8.66 1 1 495914.0625 480588.1875 1 1 0 High Q8TD08 Mitogen-activated protein kinase 15 OS=Homo sapiens OX=9606 GN=MAPK15 PE=1 SV=1 0.004 2.363 1 1 1 1 544 59.8 8.97 1 1 1847998.125 2280325.5 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular;nucleus catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf07714" 225689 ENSG00000274205.4; ENSG00000181085.14 MAPK15 8; CHR_HSCHR8_3_CTG7 0 Medium Q6NXT1 Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2 0.049 1.115 4 1 1 1 300 32.5 6.28 1 1 933537.8125 1001938.875 1 1 regulation of biological process;transport cytoplasm;nucleus enzyme regulator activity;protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 129138 ENSG00000100124.14 ANKRD54 22 0 Low Q9ULW6 Nucleosome assembly protein 1-like 2 OS=Homo sapiens OX=9606 GN=NAP1L2 PE=1 SV=1 0.065 0.977 2 1 1 1 460 52.5 4.49 1 1 13392736 364549.7813 146430.3906 1 1 1 cell organization and biogenesis;regulation of biological process nucleus protein binding Pf00956 4674 ENSG00000186462.8 NAP1L2 X 0 Medium H3BSY2 Golgin subfamily A member 8M OS=Homo sapiens OX=9606 GN=GOLGA8M PE=3 SV=1 0.046 1.161 1 1 1 1 632 71.5 7.11 1 1 1949939.25 573319.0625 456763 1 1 1 transport Golgi "Pf09730, Pf15070" 653720 ENSG00000188626.6 GOLGA8M 15 0 Low P61218 "DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Homo sapiens OX=9606 GN=POLR2F PE=1 SV=1" 0.053 1.089 6 1 1 1 127 14.5 4.22 1 1 942353.0625 407726.0625 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding Pf01192 5435 ENSG00000100142.14 POLR2F 22 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q7KZN9 Cytochrome c oxidase assembly protein COX15 homolog OS=Homo sapiens OX=9606 GN=COX15 PE=1 SV=1 0.004 2.145 2 1 1 1 410 46 9.82 1 1 1318958.75 986964.625 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;transporter activity Pf02628 1355 ENSG00000014919.12 COX15 10 Heme biosynthesis Porphyrin and chlorophyll metabolism; Oxidative phosphorylation; Metabolic pathways 0 Medium Q9Y4A5 Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3 0.018 1.642 0 1 1 1 3859 437.3 8.19 1 1 1592268.875 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus Golgi;nucleus catalytic activity;protein binding "Pf00454, Pf02259, Pf02260" 8295 ENSG00000196367.12 TRRAP 7 HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Ub-specific processing proteases HTLV-I infection 0 Medium Q92598 Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1 0.011 1.831 1 1 1 1 858 96.8 5.39 1 1 1828484.375 395890.6563 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen enzyme regulator activity;nucleotide binding;protein binding Pf00012 10808 ENSG00000120694.19 HSPH1 13 Scavenging by Class F Receptors; Regulation of HSF1-mediated heat shock response Protein processing in endoplasmic reticulum 0 Medium Q4W5G0 Tigger transposable element-derived protein 2 OS=Homo sapiens OX=9606 GN=TIGD2 PE=3 SV=1 0.046 1.164 4 1 1 1 525 59.6 9 1 1 806174.4375 3286230.5 1 1 nucleus DNA binding "Pf03184, Pf03221, Pf04218" 166815 ENSG00000180346.3 TIGD2 4 0 High Q5JPE7 Nodal modulator 2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1 0.001 3.826 1 1 1 1 1267 139.4 5.76 1 1 1281970.625 1 regulation of biological process endoplasmic reticulum;membrane protein binding "Pf09430, Pf13620, Pf13715, Pf14686" 283820 ENSG00000185164.14 NOMO2 16 0 High Q14527 Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2 0.004 2.24 1 1 1 1 1009 113.9 8.6 1 1 479166.4063 172147.25 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00097, Pf00176, Pf00271, Pf08797, Pf12678, Pf12861, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227" 6596 ENSG00000071794.15 HLTF 3 E3 ubiquitin ligases ubiquitinate target proteins 0 High Q6NS38 DNA oxidative demethylase ALKBH2 OS=Homo sapiens OX=9606 GN=ALKBH2 PE=1 SV=1 0 6.088 9 1 1 1 261 29.3 9.66 1 1 953231.3125 1 metabolic process;regulation of biological process;response to stimulus cytoskeleton;nucleus catalytic activity;metal ion binding Pf13532 121642 ENSG00000189046.10 ALKBH2 12 ALKBH2 mediated reversal of alkylation damage 0 Medium P20674 "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" 0.016 1.677 5 1 1 1 150 16.8 6.79 1 1 1555339.875 893029.0625 611810.1875 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding;transporter activity Pf02284 9377 ENSG00000178741.11 COX5A 15 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 Medium Q9UM82 Spermatogenesis-associated protein 2 OS=Homo sapiens OX=9606 GN=SPATA2 PE=1 SV=2 0.013 1.804 2 1 1 1 520 58.4 8.75 1 1 428648.6563 1 cell differentiation;development cytoplasm;nucleus protein binding Pf13771 9825 ENSG00000158480.10 SPATA2 20 0 Medium O43242 26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2 0.042 1.204 2 1 1 1 534 60.9 8.44 1 1 774638.3125 1 metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;enzyme regulator activity;protein binding "Pf01399, Pf08375" 5709 ENSG00000108344.14 PSMD3 17 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 Medium O60610 Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2 0.041 1.207 1 1 1 1 1272 141.3 5.41 1 1 289741.1875 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;protein binding;RNA binding "Pf01576, Pf02181, Pf06346, Pf06367, Pf06371, Pf11932" 1729 ENSG00000131504.15 DIAPH1 5 RHO GTPases Activate Formins; ERBB2 Regulates Cell Motility; Neutrophil degranulation AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Regulation of actin cytoskeleton; Shigellosis 0 High P49588 "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS PE=1 SV=2" 0.002 2.903 1 1 1 1 968 106.7 5.53 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;RNA binding "Pf01411, Pf02272, Pf07973" 16 ENSG00000090861.15 AARS 16 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High O94916 Nuclear factor of activated T-cells 5 OS=Homo sapiens OX=9606 GN=NFAT5 PE=1 SV=1 0.004 2.312 1 1 1 1 1531 165.7 5.24 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding "Pf00554, Pf09770" 10725 ENSG00000102908.20 NFAT5 16 0 High Q9UN37 Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1 0.002 2.863 5 1 1 1 437 48.9 7.8 1 1 647543.25 1 cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane;nucleus;vacuole catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf04389, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401" 27183 ENSG00000132612.15 VPS4A 16 Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 Low Q92560 Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2 0.05 1.108 1 1 1 1 729 80.3 6.84 1 1 2308339.75 571119.8125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding Pf01088 8314 ENSG00000163930.9 BAP1 3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; UCH proteinases 0 Medium Q9NP81 "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" 0.025 1.532 3 1 1 1 518 58.2 8.13 1 1 3901096 1175353.5 207572.4375 1 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;mitochondrion;organelle lumen catalytic activity;nucleotide binding;RNA binding "Pf00587, Pf02403, Pf06160" 54938 ENSG00000283104.1; ENSG00000104835.14 SARS2 19; CHR_HG26_PATCH Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 Medium Q9HD42 Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1 0.032 1.384 5 1 1 1 196 21.7 8.06 1 1 112201.7344 317220.8438 34597.25781 1 1 1 Acetyl [N-Term] cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;endosome;membrane;nucleus catalytic activity;metal ion binding;protein binding Pf03357 5119 ENSG00000131165.14 CHMP1A 16 Endocytosis 0 High Q9BT40 Inositol polyphosphate 5-phosphatase K OS=Homo sapiens OX=9606 GN=INPP5K PE=1 SV=3 0 4.474 2 1 1 1 448 51.1 6.54 1 1 1868732.25 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;receptor activity;signal transducer activity "Pf03372, Pf07888" 51763 ENSG00000132376.19 INPP5K 17 Synthesis of PIPs at the plasma membrane Insulin signaling pathway; Phosphatidylinositol signaling system; Inositol phosphate metabolism; Metabolic pathways 0 High Q15181 Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2 0.004 2.231 3 1 1 1 289 32.6 5.86 1 1 933842.375 278251.875 1 1 metabolic process cytoplasm;cytosol catalytic activity;metal ion binding Pf00719 5464 ENSG00000180817.11 PPA1 10 Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis Oxidative phosphorylation 0 High P61224 Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1 0.002 3.035 6 1 1 1 184 20.8 5.78 1 1 917399.5 347828.875 1 1 cell organization and biogenesis;cell proliferation;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00009, Pf00071, Pf08477" 5908 ENSG00000127314.17 RAP1B 12 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; MET activates RAP1 and RAC1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Neutrophil degranulation; Interleukin-12 family signaling; Interleukin-20 family signaling Neurotrophin signaling pathway; Rap1 signaling pathway; MAPK signaling pathway; Long-term potentiation; Renal cell carcinoma; Pancreatic secretion; Focal adhesion; Leukocyte transendothelial migration; Ras signaling pathway; Chemokine signaling pathway; cAMP signaling pathway; Platelet activation 0 High Q92667 "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" 0 5.932 3 1 1 1 903 97.3 4.94 1 1 1634397.625 738095.5625 1 1 coagulation;regulation of biological process cytosol;membrane;mitochondrion protein binding;RNA binding "Pf00013, Pf00567, Pf12072, Pf13014" 8165 ENSG00000121057.12 AKAP1 17 Mitochondrial calcium ion transport; Factors involved in megakaryocyte development and platelet production 0 High Q9BQC6 "Ribosomal protein 63, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL57 PE=1 SV=1" 0 4.567 13 1 1 1 102 12.3 11.44 1 1 1443678.375 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf14978 78988 ENSG00000173141.4 MRP63; MRPL57 13 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q8NCW0 Kremen protein 2 OS=Homo sapiens OX=9606 GN=KREMEN2 PE=2 SV=1 0.005 2.095 2 1 1 1 462 48.8 7.46 1 1 221437.7969 1 cell communication;regulation of biological process;response to stimulus membrane "Pf00051, Pf00431, Pf01822" 79412 ENSG00000131650.13 KREMEN2 16 Negative regulation of TCF-dependent signaling by WNT ligand antagonists; Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling 0 High Q15645 Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2 0.001 3.885 3 1 1 1 432 48.5 6.09 1 1 439262.0625 736791.8125 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf02367, Pf05496, Pf06068, Pf07726, Pf07728, Pf13191, Pf13207, Pf13238, Pf13401, Pf13521, Pf13671" 9319 ENSG00000071539.13 TRIP13 5 0 High Q2V2M9 FH1/FH2 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FHOD3 PE=1 SV=2 0.002 2.912 2 1 1 1 1422 158.5 5.99 1 1 85008.79688 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding Pf02181 80206 ENSG00000134775.15 FHOD3 18 0 Medium Q14558 Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2 0.016 1.679 4 1 1 1 356 39.4 7.2 1 1 781904.625 217665.0938 1 1 metabolic process;regulation of biological process catalytic activity;enzyme regulator activity;metal ion binding;protein binding "Pf13793, Pf14572" 5635 PRPSAP1 17 0 Medium P0C221 Coiled-coil domain-containing protein 175 OS=Homo sapiens OX=9606 GN=CCDC175 PE=4 SV=2 0.033 1.378 1 1 1 1 793 93.6 6.71 1 1 775145.1875 969237.5 183729.5781 1 1 1 729665 ENSG00000151838.11 CCDC175 14 0 High Q6P2C8 Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens OX=9606 GN=MED27 PE=1 SV=1 0 4.446 5 1 1 1 311 35.4 9.31 1 1 2985.018799 507837.75 679430.6875 1 1 1 metabolic process;regulation of biological process cytosol;nucleus catalytic activity;protein binding Pf11571 9442 ENSG00000160563.13 MED27 9 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 Medium Q8WUQ7 Cactin OS=Homo sapiens OX=9606 GN=CACTIN PE=1 SV=3 0.013 1.778 2 1 1 1 758 88.6 9.14 1 1 1219929.25 1680142.25 1 1 defense response;development;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf09732, Pf10312" 58509 ENSG00000105298.13 CACTIN 19 0 High O60244 Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2 0.004 2.344 1 1 1 1 1454 160.5 8.73 1 1 495619.9688 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity "Pf08638, Pf15449" 9282 ENSG00000180182.10 MED14 X Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 Medium P30414 NK-tumor recognition protein OS=Homo sapiens OX=9606 GN=NKTR PE=1 SV=2 0.013 1.801 1 1 1 1 1462 165.6 9.99 1 1 metabolic process cytosol;membrane;mitochondrion catalytic activity "Pf00160, Pf09726" 4820 ENSG00000114857.17 NKTR 3 0 Medium P35606 Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2 0.039 1.242 1 1 1 1 906 102.4 5.27 1 1 454467.1563 625588.5625 1 1 transport cytoplasm;cytosol;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053" 9276 ENSG00000184432.9 COPB2 3 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport 0 High Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens OX=9606 GN=CYLD PE=1 SV=1 0.006 2.033 1 1 1 1 956 107.2 5.59 1 1 2927341.5 312897.9688 1 1 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;metal ion binding;protein binding;structural molecule activity Pf01302 1540 ENSG00000083799.17 CYLD 16 Ub-specific processing proteases; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling; TNFR1-induced proapoptotic signaling; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway Osteoclast differentiation; RIG-I-like receptor signaling pathway 0 High P59998 Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3 0.004 2.172 5 1 1 1 168 19.7 8.43 1 1 531301.0625 486774.0625 311816.0313 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity Pf05856 10093 ENSG00000241553.12 ARPC4 3 EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Pathogenic Escherichia coli infection; Salmonella infection; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Fc gamma R-mediated phagocytosis; Shigellosis 0 High P56545 C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1 0.001 3.259 4 1 1 1 445 48.9 6.95 1 1 cell differentiation;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00389, Pf02826" 1488 ENSG00000175029.16 CTBP2 10 Repression of WNT target genes; TCF7L2 mutants don't bind CTBP Chronic myeloid leukemia; Pathways in cancer; Wnt signaling pathway; Notch signaling pathway 0 High Q15334 Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3 0.003 2.759 2 1 1 1 1064 115.3 6.29 1 1 136701.3281 1853915.75 922302.5 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;endosome;Golgi;membrane enzyme regulator activity;protein binding;structural molecule activity Pf08366 3996 ENSG00000131899.10; ENSG00000284137.1 LLGL1 17; CHR_HSCHR17_3_CTG1 Tight junction; Hippo signaling pathway 0 High P61962 DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1 0.001 3.487 6 1 1 1 342 38.9 5.52 1 1 193870.1406 1 development;metabolic process cytoplasm;cytosol;nucleus protein binding Pf00400 10238 ENSG00000136485.14 DCAF7 17 Association of TriC/CCT with target proteins during biosynthesis; Neddylation 0 Medium Q9UBT2 SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2 0.022 1.588 1 1 1 1 640 71.2 5.29 1 1 4047217.25 370822.125 1 1 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00899, Pf02134, Pf10585, Pf14732" 10054 ENSG00000126261.12 UBA2 19 "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" Ubiquitin mediated proteolysis 0 High O76031 "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" 0.004 2.173 1 1 1 1 633 69.2 7.58 1 1 441640.0313 569996.875 1 1 metabolic process;regulation of biological process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00004, Pf01078, Pf05729, Pf07724, Pf07726, Pf07728, Pf10431, Pf13401, Pf14532" 10845 ENSG00000166855.9 CLPX 15 0 Medium P0DPI3 Centromere protein V-like protein 2 OS=Homo sapiens OX=9606 GN=CENPVL2 PE=3 SV=1 0.027 1.481 3 1 1 1 272 29.9 10.11 1 1 0 High Q9UF56 F-box/LRR-repeat protein 17 OS=Homo sapiens OX=9606 GN=FBXL17 PE=1 SV=3 0.006 2.034 2 1 1 1 701 75.6 8.07 1 1 497680.4375 1 protein binding "Pf00646, Pf12937" 64839 ENSG00000145743.15 FBXL17 5 0 High O60783 "28S ribosomal protein S14, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1" 0.001 3.276 12 1 1 1 128 15.1 11.41 1 1 2310816 8337.826172 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00253 63931 ENSG00000120333.4 MRPS14 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9BZX2 Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1 0.003 2.618 4 1 1 1 261 29.3 6.7 1 1 metabolic process cytosol catalytic activity;nucleotide binding "Pf00485, Pf13207" 7371 ENSG00000143179.14 UCK2 1 Pyrimidine salvage Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 High Q9BTT4 Mediator of RNA polymerase II transcription subunit 10 OS=Homo sapiens OX=9606 GN=MED10 PE=1 SV=1 0.003 2.444 7 1 1 1 135 15.7 6.19 1 1 1446362.75 1 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf09748 84246 ENSG00000133398.3 MED10 5 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 Medium Q9HBM6 Transcription initiation factor TFIID subunit 9B OS=Homo sapiens OX=9606 GN=TAF9B PE=1 SV=1 0.046 1.169 3 1 1 1 251 27.6 9.55 1 1 450713.2188 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;protein binding Pf02291 51616 ENSG00000187325.4 TAF9B X Ub-specific processing proteases; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape Basal transcription factors; Herpes simplex infection 0 Medium Q15051 IQ calmodulin-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=IQCB1 PE=1 SV=1 0.04 1.23 1 1 1 1 598 68.9 9.1 1 1 84521.85938 884579.0625 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding Pf00612 9657 ENSG00000173226.16 IQCB1 3 Anchoring of the basal body to the plasma membrane 0 High Q15125 "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase OS=Homo sapiens OX=9606 GN=EBP PE=1 SV=3" 0.001 3.83 7 1 1 1 230 26.3 7.9 1 1 757010.6875 818418.3125 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity Pf05241 10682 ENSG00000147155.10 EBP X Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol Steroid biosynthesis; Metabolic pathways 0 High Q6L9W6 "Beta-1,4-N-acetylgalactosaminyltransferase 3 OS=Homo sapiens OX=9606 GN=B4GALNT3 PE=1 SV=2" 0.003 2.599 2 1 1 1 998 114.9 7.49 1 1 974986.9375 313642.7813 475655.5313 1 1 1 Golgi;membrane;nucleus catalytic activity "Pf02709, Pf05679, Pf06862, Pf07691, Pf13388" 283358 ENSG00000139044.10 B4GALNT3 12 Metabolic pathways 0 High P43251 Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2 0.004 2.333 3 1 1 1 543 61.1 6.25 1 1 214309.4531 1 metabolic process extracellular;organelle lumen catalytic activity Pf00795 686 ENSG00000169814.12 BTD 3 Defective BTD causes biotidinase deficiency; Biotin transport and metabolism Vitamin digestion and absorption; Biotin metabolism; Metabolic pathways 0 High Q15554 Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3 0 4.932 4 1 1 1 542 59.6 9.35 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;protein binding "Pf00249, Pf08558, Pf13921" 7014 ENSG00000132604.10 TERF2 16 Meiotic synapsis; DNA Damage/Telomere Stress Induced Senescence; Packaging Of Telomere Ends 0 Low O75947 "ATP synthase subunit d, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PD PE=1 SV=3" 0.069 0.934 14 1 1 1 161 18.5 5.3 1 1 11298654 1 cell organization and biogenesis;metabolic process;transport cytosol;membrane;mitochondrion catalytic activity;transporter activity Pf05873 10476 ENSG00000167863.11 ATP5H 17 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 Medium Q96G97 Seipin OS=Homo sapiens OX=9606 GN=BSCL2 PE=1 SV=3 0.015 1.753 2 1 1 1 398 44.4 5.17 1 1 2123856.5 435312.8438 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane enzyme regulator activity;protein binding "Pf03344, Pf05395, Pf06775" 26580 ENSG00000168000.14 BSCL2 11 0 High Q9C0K3 Actin-related protein 3C OS=Homo sapiens OX=9606 GN=ACTR3C PE=2 SV=1 0.003 2.462 5 1 1 1 210 23.7 5.58 1 1 134678.1094 1 cell organization and biogenesis;regulation of biological process nucleotide binding;protein binding Pf00022 653857 ENSG00000106526.10 ACTR3C 7 0 Medium Q86VW0 SEC14 domain and spectrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=SESTD1 PE=1 SV=2 0.015 1.691 2 1 1 1 696 79.3 5.1 1 1 516968.125 9789.458984 2400.208496 1 1 1 Acetyl [N-Term] protein binding Pf13716 91404 ENSG00000187231.13 SESTD1 2 0 High O95201 Zinc finger protein 205 OS=Homo sapiens OX=9606 GN=ZNF205 PE=1 SV=2 0.002 3.091 4 1 1 1 554 60.6 8.54 1 1 561671.1875 1 metabolic process;regulation of biological process mitochondrion;nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf01352, Pf13465" 7755 ENSG00000122386.10 ZNF205 16 Generic Transcription Pathway 0 Medium P51513 RNA-binding protein Nova-1 OS=Homo sapiens OX=9606 GN=NOVA1 PE=1 SV=2 0.04 1.23 2 1 1 1 507 51.7 8.72 1 1 91282.99219 6424240 1 1 0 Medium Q9NVE7 Pantothenate kinase 4 OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1 0.026 1.514 2 1 1 1 773 85.9 6.28 1 1 365984.9688 1362433.375 1 1 metabolic process cytoplasm catalytic activity;nucleotide binding "Pf01937, Pf03630" 55229 ENSG00000273494.3 PANK4 1; CHR_HSCHR1_1_CTG3 Coenzyme A biosynthesis Pantothenate and CoA biosynthesis; Metabolic pathways 0 Medium Q969V6 Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1 0.023 1.548 2 1 1 1 931 98.9 5.86 1 1 89876.46875 753851.4375 1 1 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus protein binding "Pf02037, Pf02755" 57591 ENSG00000196588.14 MKL1 22 RHO GTPases Activate Formins 0 Medium P11310 "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" 0.019 1.622 2 1 1 1 421 46.6 8.37 1 1 2647672.5 410388.4375 1 1 metabolic process;regulation of biological process membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00441, Pf02770, Pf02771, Pf08028, Pf11794" 34 ENSG00000117054.13 ACADM 1 PPARA activates gene expression; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Fatty acid degradation; Propanoate metabolism; Carbon metabolism; PPAR signaling pathway; beta-Alanine metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 Medium P33991 DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5 0.046 1.175 2 1 1 1 863 96.5 6.74 1 1 metabolic process membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 4173 ENSG00000104738.16 MCM4 8 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High O95456 Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1 0.004 2.402 4 1 1 1 288 32.8 7.17 1 1 276734.9375 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cell proliferation cytoplasm;cytosol;endoplasmic reticulum;Golgi;nucleus protein binding 8624 ENSG00000183527.11 PSMG1 21 0 High Q9BQP7 Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1 0.002 2.899 3 1 1 1 344 39.4 7.68 1 1 266184.9375 635305.0625 1 1 cell organization and biogenesis;metabolic process;response to stimulus mitochondrion catalytic activity;DNA binding 92667 ENSG00000125871.13 C20orf72; MGME1 20 0 High P20930 Filaggrin OS=Homo sapiens OX=9606 GN=FLG PE=1 SV=3 0.002 3.097 0 1 1 1 4061 434.9 9.25 1 1 77906.29688 994428.625 694064.25 1 1 1 cell death;cell differentiation;development;metabolic process cytoskeleton;cytosol;nucleus metal ion binding;protein binding;structural molecule activity Pf01023 2312 ENSG00000143631.10 FLG 1 Formation of the cornified envelope 0 High P35544 Ubiquitin-like protein FUBI OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1 0.001 4.272 26 1 1 1 74 7.8 4.35 1 1 2534158.5 348536.625 405962.3125 1 1 1 protein binding;RNA binding "Pf00240, Pf11976" 2197 FAU 11 Ribosome 0 High Q6P1L8 "39S ribosomal protein L14, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" 0.001 3.429 13 1 1 1 145 15.9 10.24 1 1 2476169 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00238 64928 ENSG00000180992.6 MRPL14 6 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q5TB30 DEP domain-containing protein 1A OS=Homo sapiens OX=9606 GN=DEPDC1 PE=1 SV=2 0 7.075 2 1 1 1 811 92.9 8.68 1 1 926237.5625 1 metabolic process;regulation of biological process;response to stimulus nucleus enzyme regulator activity;protein binding "Pf00610, Pf00620" 55635 ENSG00000024526.16 DEPDC1 1 0 Medium P40925 "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" 0.047 1.151 5 1 1 1 334 36.4 7.36 1 1 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00056, Pf02866" 4190 ENSG00000014641.17 MDH1 2 Gluconeogenesis Citrate cycle (TCA cycle); Carbon metabolism; Pyruvate metabolism; Proximal tubule bicarbonate reclamation; Metabolic pathways; Cysteine and methionine metabolism; Glyoxylate and dicarboxylate metabolism 0 Medium Q9Y4C2 TRPM8 channel-associated factor 1 OS=Homo sapiens OX=9606 GN=TCAF1 PE=1 SV=3 0.041 1.207 1 1 1 1 921 102.1 6.54 1 1 395318.0313 588527.3125 1 1 regulation of biological process;transport membrane protein binding Pf13402 9747 ENSG00000198420.9 FAM115A; TCAF1 7 0 High P43686 26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2 0.003 2.481 4 1 1 1 418 47.3 5.21 1 1 95769.21875 19048.8418 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00006, Pf00910, Pf01057, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191" 5704 ENSG00000281221.2; ENSG00000013275.7 PSMC4 19; CHR_HG2021_PATCH Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0