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DMFold Human Proteome Models
Modeling of Human Proteome by DMFold with DeepMSA2 MSA
This database lists structural models by DMFold for 5042 difficult proteins in human proteome. The model confidence is assessed by the predicted LDDT (pLDDT) score, where a higher pLDDT score signifies a higher model confidence. Usually, pLDDT score>0.7 indicates a correct fold. Here, two sets of DMFold models are listed: ‘v1’ refers to the models built with the 'pLDDT' pre-trained parameters and ‘v2’ to the models built with the 'pTM' pre-trained parameters. On average, the ‘v1’ models have a slightly higher pLDDT score than the ‘v2’ models, and users are suggested to select the models with a higher pLDDT score.
References:
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Qiqige Wuyun, Quancheng Liu, Yiying Guo, Lydia Freddolino, Wei Zheng.
DMFold: A deep learning platform for protein complex structure and function predictions based on DeepMSA2.
In preparation.
- Wei Zheng, Qiqige Wuyun, Yang Li, Chengxin Zhang, P Lydia Freddolino, Yang Zhang.
Improving deep learning protein monomer and complex structure prediction using DeepMSA2 with huge metagenomics data.
Nature Methods, January 2024. https://doi.org/10.1038/s41592-023-02130-4.
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Wei Zheng, Qiqige Wuyun, Peter L Freddolino, Yang Zhang.
Integrating deep learning, threading alignments, and a multi-MSA strategy for high-quality protein monomer and complex structure prediction in CASP15.
1-20. Proteins. (2023). doi:10.1002/prot.26585.
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