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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Endothelin-1 receptor
Species	Homo sapiens (Human)
Gene	EDNRA
Synonym	ET-A ETA-R hET-AR ETA receptor ENDOR endothelin A receptor Endothelin receptor type A {ECO:0000312\|HGNC:HGNC:3179} ET-AR endothelin-1 receptor Gpcr10 [ Show all ]
Disease	Vasospasm following subarachnoid hemorrhage Hormone refractory prostate cancer Hormone resistant prostate cancer Hypertension Hypotension Nerve injury Premature labour Prostate cancer Pulmonary arterial hypertension Pulmonary hypertension Solid tumours Unspecified Heart disease Cerebrovascular disorders Diabetic nephropathy [ Show all ]
Length	427
Amino acid sequence	METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
UniProt	P25101
Protein Data Bank	N/A
GPCR-HGmod model	P25101
3D structure model	This predicted structure model is from GPCR-EXP P25101.
BioLiP	N/A
Therapeutic Target Database	T23499
ChEMBL	CHEMBL252
IUPHAR	219
DrugBank	BE0000521

Ligand

Name	CHEMBL359273
Molecular formula	C21H18N4O3S
IUPAC name	N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-(4-pyrimidin-2-ylphenyl)benzenesulfonamide
Molecular weight	406.46
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.6
Synonyms	SCHEMBL7947185 BDBM50109666 L015402 4''-Pyrimidin-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-pyrimidinyl)biphenyl-2-sulfonamide
Inchi Key	AZYAXQRVKZNKCU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H18N4O3S/c1-14-15(2)24-28-21(14)25-29(26,27)19-7-4-3-6-18(19)16-8-10-17(11-9-16)20-22-12-5-13-23-20/h3-13,25H,1-2H3
PubChem CID	9822616
ChEMBL	CHEMBL359273
IUPHAR	N/A
BindingDB	50109666
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kb	21.0 nM	PMID11844662	ChEMBL
Ki	0.9 nM	PMID11844662	BindingDB
Ki	0.9 nM	PMID11844662	ChEMBL

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