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Name | Muscarinic acetylcholine receptor M2 |
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Species | Rattus norvegicus (Rat) |
Gene | Chrm2 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P10980 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL309 |
IUPHAR | 14 |
DrugBank | N/A |
Name | pilocarpine |
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Molecular formula | C11H16N2O2 |
IUPAC name | (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one |
Molecular weight | 208.261 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 1.1 |
Synonyms | Spectrum3_000546 Timpilo (TN) LS-7661 (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-07 [ Show all ] |
Inchi Key | QCHFTSOMWOSFHM-WPRPVWTQSA-N |
Inchi ID | InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 |
PubChem CID | 5910 |
ChEMBL | CHEMBL550 |
IUPHAR | 305 |
BindingDB | 50008072 |
DrugBank | DB01085 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 8800.0 nM | , Bioorg. Med. Chem. Lett., (1991) 1:3:147 | BindingDB,ChEMBL |
Intrinsic activity | 48.0 % | Bioorg. Med. Chem. Lett., (1995) 5:16:1813 | ChEMBL |
Kd | 10000.0 nM | PMID1732522 | BindingDB,ChEMBL |
Ki | <10000.0 nM | PMID1310135 | BindingDB |
Ki | 7000.0 nM | PMID4151898 | BindingDB |
Ki | 9800.0 nM | , Bioorg. Med. Chem. Lett., (1995) 5:16:1813 | BindingDB,ChEMBL |
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