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GPCR

Name	Alpha-1B adrenergic receptor
Species	Mesocricetus auratus (Golden hamster)
Gene	ADRA1B
Synonym	Alpha-1B adrenoceptor Alpha-1B adrenoreceptor
Disease	N/A for non-human GPCRs
Length	515
Amino acid sequence	MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
UniProt	P18841
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3122
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	terazosin
Molecular formula	C19H25N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
Molecular weight	387.44
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	1.4
Synonyms	NCGC00016026-08 141269-44-5 Prestwick3_000751 6,7-Dimethoxy-2-[4-(tetrahydro-2-furanylcarbonyl)-1-piperazinyl]-4-quinazolinamine # Terazosabb (TN) A-45975 Terazosine BDBM50033111 Z1172269406 CCG-205212 HMS2090P21 Hytrin (TN) MFCD00467965 MLS006011889 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine Opera_ID_1910 SCHEMBL6528 63074-08-8 (hydrochloride) terazosin a AC-11120 Terazosinum [INN-Latin] BRD-A22256192-003-03-7 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone CHEMBL611 Flumarc HMS3369P14 Lopac0_001138 NCGC00016026-04 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick1_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-imine STK567029 Terazosina AN-38972 Vasomet C07127 D08569 GTPL7302 Hytracin MET029 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine NCGC00016026-11 141269-45-6 REGID_for_CID_5401 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine Abbott 45975 Terazosine [INN-French] Blavin [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone CHEBI:9445 DB01162 HMS2232N21 KB-147102 MLS000069703 MolPort-001-684-489 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)- 590T647 SMR000058309 63590-64-7 Terazosin HCl AC1L1K9W Trazosin HCl BRD-A22256192-003-14-4 CPD000058309 Fosfomic HMS3371E20 LS-110234 (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone NCGC00016026-05 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2RS)-2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine Prestwick2_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine Terazosabb A 45975 Terazosina [INN-Spanish] BBL010743 VCKUSRYTPJJLNI-UHFFFAOYSA-N C19H25N5O4 D0P9RF H963 Hytrin Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)- 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine NCGC00025191-03 4097AH SAM002589982 6,7-dimethoxy-2-{4-[(oxolan-2-yl)carbonyl]piperazin-1-yl}quinazolin-4-amine Terazosin (INN) Abbott-45975 Terazosinum BPBio1_000840 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone DTXSID3023639 HMS3259F04 L000692 MLS001201836 NC00689 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick0_000751 6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine SPBio_002701 70024-40-7 (mono-hydrochloride, dihydrate) Terazosin [INN:BAN] AKOS005266642 VA11839 BSPBio_000762 CS-2429 FT-0630739 HY-B0371 MCULE-4030111564 [ Show all ]
Inchi Key	VCKUSRYTPJJLNI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
PubChem CID	5401
ChEMBL	CHEMBL611
IUPHAR	7302
BindingDB	50033111
DrugBank	DB01162
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.69 nM	PMID10780916	BindingDB,ChEMBL

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