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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | Clorotepine |
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Molecular formula | C19H21ClN2S |
IUPAC name | 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methylpiperazine |
Molecular weight | 344.901 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 4.3 |
Synonyms | DTXSID7048451 Octoclothepin SCHEMBL678917 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methyl-piperazine;maleate 4789-68-8 (2-maleate salt) [ Show all ] |
Inchi Key | XRYLGRGAWQSVQW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H21ClN2S/c1-21-8-10-22(11-9-21)17-12-14-4-2-3-5-18(14)23-19-7-6-15(20)13-16(17)19/h2-7,13,17H,8-12H2,1H3 |
PubChem CID | 1238 |
ChEMBL | CHEMBL64249 |
IUPHAR | N/A |
BindingDB | 22872 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.8 nM | PMID8522988 | PDSP,BindingDB |
Ki | 2.6 nM | PMID8522988 | PDSP,BindingDB |
Ki | >50.0 nM | PMID15771424 | ChEMBL |
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