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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Mus musculus (Mouse)
Gene	Crhr2
Synonym	CRFR-2 CRFR2 CRFR2alpha CRFR2beta CRH-R-2 CRF2 receptor CRF-RB CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 CRH-R2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	411
Amino acid sequence	MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q60748
Protein Data Bank	2jnd
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2jnd.
BioLiP	BL0101313
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2253
IUPHAR	213
DrugBank	N/A

Ligand

Name	CHEMBL350784
Molecular formula	C22H20N4O2
IUPAC name	N-[(1R,2S)-2-aminocyclohexyl]-7-oxobenzo[e]perimidine-4-carboxamide
Molecular weight	372.428
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.4
Synonyms	7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R,2S)-2-amino-cyclohexyl)-amide BDBM50075923 N-[(1R)-2beta-Aminocyclohexane-1beta-yl]-7-oxo-7H-benzo[e]perimidine-4-carboxamide
Inchi Key	YEIPENKZKGYLPU-DLBZAZTESA-N
Inchi ID	InChI=1S/C22H20N4O2/c23-16-7-3-4-8-17(16)26-22(28)15-10-9-14-18-19(24-11-25-20(15)18)12-5-1-2-6-13(12)21(14)27/h1-2,5-6,9-11,16-17H,3-4,7-8,23H2,(H,26,28)/t16-,17+/m0/s1
PubChem CID	15381047
ChEMBL	CHEMBL350784
IUPHAR	N/A
BindingDB	50075923
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID10201844	BindingDB,ChEMBL

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