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Name | Muscarinic acetylcholine receptor M2 |
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Species | Mus musculus (Mouse) |
Gene | Chrm2 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGGTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDDNSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | Q9ERZ4 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3197 |
IUPHAR | 14 |
DrugBank | N/A |
Name | BRN 5356615 |
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Molecular formula | C22H36N2O2S2 |
IUPAC name | 1-[5-[6-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]hexylsulfanylmethyl]furan-2-yl]-N,N-dimethylmethanamine |
Molecular weight | 424.662 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 3.9 |
Synonyms | BDBM50005509 2,2'-[1,6-Hexanediylbis(thiomethylene)]bis[5-(dimethylaminomethyl)furan] CHEMBL268499 {5-[6-(5-Dimethylaminomethyl-furan-2-ylmethylsulfanyl)-hexylsulfanylmethyl]-furan-2-ylmethyl}-dimethyl-amine 1-[5-[6-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]hexylsulfanylmethyl]furan-2-yl]-N,N-dimethylmethanamine [ Show all ] |
Inchi Key | ZRDXAEKCZXNZEQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H36N2O2S2/c1-23(2)15-19-9-11-21(25-19)17-27-13-7-5-6-8-14-28-18-22-12-10-20(26-22)16-24(3)4/h9-12H,5-8,13-18H2,1-4H3 |
PubChem CID | 3071775 |
ChEMBL | CHEMBL268499 |
IUPHAR | N/A |
BindingDB | 50005509 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 580.0 nM | PMID1552502 | BindingDB,ChEMBL |
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