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Name | Orexin receptor type 2 |
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Species | Rattus norvegicus (Rat) |
Gene | Hcrtr2 |
Synonym | hypocretin receptor 2 Hypocretin receptor type 2 hypocretin (orexin) receptor 2 orexin receptor type 2 Ox-2-R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV |
UniProt | P56719 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1275216 |
IUPHAR | 322 |
DrugBank | N/A |
Name | CHEMBL3586437 |
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Molecular formula | C21H23N7O |
IUPAC name | [(3aS,6aR)-2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-(1H-1,2,4-triazol-5-yl)phenyl]methanone |
Molecular weight | 389.463 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 2.4 |
Synonyms | BDBM50097379 |
Inchi Key | NYDBXNHNMPHNGA-IYBDPMFKSA-N |
Inchi ID | InChI=1S/C21H23N7O/c1-13-7-14(2)25-21(24-13)28-10-15-8-27(9-16(15)11-28)20(29)18-6-4-3-5-17(18)19-22-12-23-26-19/h3-7,12,15-16H,8-11H2,1-2H3,(H,22,23,26)/t15-,16+ |
PubChem CID | 122180340 |
ChEMBL | CHEMBL3586437 |
IUPHAR | N/A |
BindingDB | 50097379 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 39.0 nM | PMID26087021 | BindingDB,ChEMBL |
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