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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS001002564
Molecular formulaC17H14N2O4
IUPAC name3-[(3-methoxyphenyl)methyl]-4-oxophthalazine-1-carboxylic acid
Molecular weight310.309
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.3
SynonymsMCULE-9710387993
3-[(3-methoxyphenyl)methyl]-4-oxo-1-phthalazinecarboxylic acid
BDBM97120
SMR000369086
4-keto-3-m-anisyl-phthalazine-1-carboxylic acid
[ Show all ]
Inchi KeyCXBZVDGOWGPODJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H14N2O4/c1-23-12-6-4-5-11(9-12)10-19-16(20)14-8-3-2-7-13(14)15(18-19)17(21)22/h2-9H,10H2,1H3,(H,21,22)
PubChem CID2559619
ChEMBLCHEMBL1486272
IUPHARN/A
BindingDB97120
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<29934.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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