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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS001177315
Molecular formulaC25H26N2O4
IUPAC nameN-[2-[(2,3-dimethoxyphenyl)methyl-methylamino]-2-oxoethyl]-4-phenylbenzamide
Molecular weight418.493
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.8
SynonymsZ31870592
878212-71-6
HMS2899H04
MolPort-004-153-571
AKOS034173564
[ Show all ]
Inchi KeyCZYJLQYRCXIZPK-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H26N2O4/c1-27(17-21-10-7-11-22(30-2)24(21)31-3)23(28)16-26-25(29)20-14-12-19(13-15-20)18-8-5-4-6-9-18/h4-15H,16-17H2,1-3H3,(H,26,29)
PubChem CID9166749
ChEMBLCHEMBL1478397
IUPHARN/A
BindingDB97141
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1108.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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