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GPCR

NameUracil nucleotide/cysteinyl leukotriene receptor
SpeciesMus musculus (Mouse)
GeneGpr17
SynonymG-protein coupled receptor 17
GPR17
P2Y-like receptor
R12
UDP/CysLT receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length339
Amino acid sequenceMNGLEAALPSLTDNSSLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCAAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL
UniProtQ6NS65
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR88
DrugBankN/A

Ligand

Nameleukotriene E4
Molecular formulaC23H37NO5S
IUPAC name(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
Molecular weight439.611
Hydrogen bond acceptor7
Hydrogen bond donor4
XlogP2.1
SynonymsBSPBio_001370
GTPL3352
NCGC00163400-01
[5S-[5R*,6S*(S*),7E,9E,11Z,14Z]]- 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-Eicosatetraenoate
1826AH
[ Show all ]
Inchi KeyOTZRAYGBFWZKMX-FRFVZSDQSA-N
Inchi IDInChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
PubChem CID5280879
ChEMBLCHEMBL509456
IUPHAR5863, 3352
BindingDB50297387
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC500.31 nMPMID18974869IUPHAR

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