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Name | D(3) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD3 |
Synonym | dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor |
Disease | Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders [ Show all ] |
Length | 400 |
Amino acid sequence | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC |
UniProt | P35462 |
Protein Data Bank | 3pbl |
GPCR-HGmod model | P35462 |
3D structure model | This structure is from PDB ID 3pbl. |
BioLiP | BL0191566, BL0191567 |
Therapeutic Target Database | T02551 |
ChEMBL | CHEMBL234 |
IUPHAR | 216 |
DrugBank | BE0000581 |
Name | CHEMBL71327 |
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Molecular formula | C21H23Cl2N3O |
IUPAC name | N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]benzamide |
Molecular weight | 404.335 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 4.4 |
Synonyms | N-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-benzamide BDBM50129433 N-[(E)-4-[4-(2,3-Dichlorophenyl)piperazino]-2-butenyl]benzamide N-{(E)-4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-benzamide |
Inchi Key | DHOCETPWLQILEE-SNAWJCMRSA-N |
Inchi ID | InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4+ |
PubChem CID | 10001256 |
ChEMBL | CHEMBL71327 |
IUPHAR | N/A |
BindingDB | 50129433 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <10000.0 nM | PMID12798330 | BindingDB,ChEMBL |
EC50 | 7.7 - | PMID15689168 | ChEMBL |
IC50 | 7.7 nM | PMID12798330 | BindingDB |
IC50 | 7.71 nM | PMID15916415 | BindingDB,ChEMBL |
IC50 | 7.72 nM | PMID12798330 | ChEMBL |
Ki | 0.8 nM | PMID15916415, PMID15689168 | BindingDB,ChEMBL |
Ki | 6.02 nM | PMID15916415 | BindingDB,ChEMBL |
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