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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameBDBM97075
Molecular formulaC28H25Cl2N3O3
IUPAC namemethyl 4-[1-[(2,4-dichlorophenyl)methyl]-3-phenylpyrazol-4-yl]-2-methyl-5-oxo-4a,6,7,8-tetrahydro-4H-quinoline-3-carboxylate
Molecular weight522.426
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.8
Synonymsmethyl 4-[1-[(2,4-dichlorophenyl)methyl]-3-phenyl-pyrazol-4-yl]-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
4-[1-(2,4-dichlorobenzyl)-3-phenyl-pyrazol-4-yl]-5-keto-2-methyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylic acid methyl ester
4-[1-[(2,4-dichlorophenyl)methyl]-3-phenyl-4-pyrazolyl]-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylic acid methyl ester
cid_3380750
Inchi KeyAMFDTNFYUAMVNX-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H25Cl2N3O3/c1-16-24(28(35)36-2)25(26-22(31-16)9-6-10-23(26)34)20-15-33(14-18-11-12-19(29)13-21(18)30)32-27(20)17-7-4-3-5-8-17/h3-5,7-8,11-13,15,25-26H,6,9-10,14H2,1-2H3
PubChem CID91899623
ChEMBLN/A
IUPHARN/A
BindingDB97075
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC503848.0 nMN/ABindingDB

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