3tik/1/1:A/1:B |
| >3tik-a1-m1-cA (length=450) [Search sequence] |
KGKLPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHS
RFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQ
HEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESS
LIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLS
AVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFP
AQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLS
HHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQL
LRDEVPDPDYHTMVVGPTASQCRVKYIRRK |
| >3tik-a1-m1-cB (length=450) [Search sequence] |
KGKLPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHS
RFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQ
HEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESS
LIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLS
AVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFP
AQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLS
HHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQL
LRDEVPDPDYHTMVVGPTASQCRVKYIRRK |
|
| PDB ID |
3tik (database links:
RCSB PDB
PDBe
PDBj
PDBsum) |
| Title |
Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one |
| Assembly ID |
1 |
| Resolution |
2.05Å |
| Method of structure determination |
X-RAY DIFFRACTION |
| Number of inter-chain contacts |
47 |
| Sequence identity between the two chains |
1.0 |
| PubMed citation |
22777048 |
|
|
Chain 1 |
Chain 2 |
| Model ID |
1 |
1 |
| Chain ID |
A |
B |
| UniProt accession |
Q385E8 |
Q385E8 |
| Species |
5691 (Trypanosoma brucei) |
5691 (Trypanosoma brucei) |
| Function annotation |
BioLiP:3tikA |
BioLiP:3tikB |
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Switch viewer: [NGL] [JSmol]
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Dimer structure:
Chain 1 in red;
Chain 2 in blue.
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Full biological assembly
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