7mqs/1/1:E/1:F

Sequences
>7mqs-a1-m1-cE (length=806) [Search sequence]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLF
RVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNE
LCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTNCPATQFVERCWTHSHCQKVCP
TICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRC
VNFSFCQDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEK
TIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSL
SFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEI
HKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRD
LLGFMLFYKEAPYQNVVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSD
ERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWER
QAEDSELFELDYCLKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPREEHRPFEKVVN
KESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFE
NNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSV
RIRATSLAGNGSWTEPTYFYVTDYLD
>7mqs-a1-m1-cF (length=811) [Search sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDY
LLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIE
KNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTNCPATVINGQFVERCWTH
SHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPY
YHFQDWRCVNFSFCQDLHHKCKNSRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYL
KIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFF
HYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLR
WEPYWPPDFRDLLGFMLFYKEAPYQNVTEFSWTVVDIDPPLRSNDPKSQNHPGWLMRGLK
PWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKP
PSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRLEESSFRKTFEDYLHEEHRPF
EKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVT
HEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSP
GNYSVRIRATSLAGNGSWTEPTYFYVTDYLD
Structure information
PDB ID 7mqs (database links: RCSB PDB PDBe PDBj PDBsum)
Title The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Assembly ID 1
Resolution 4.4Å
Method of structure determination ELECTRON MICROSCOPY
Number of inter-chain contacts 73
Sequence identity between the two chains 0.985
PubMed citation 35289328
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID E F
UniProt accession P06213 P06213
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:7mqsE BioLiP:7mqsF
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 7mqs-a1-m1-cE_7mqs-a1-m1-cF.pdb.gz
Full biological assembly
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Download: 7mqs-assembly1.cif.gz

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