8e0q/1/1:A/1:B

Sequences

>8e0q-a1-m1-cA (length=1689) [Search sequence]

MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF LLEDGRVCRIGFSVQPDRLSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLS SVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAK NKPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNEEQWSLREVVFVE DVTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQE NNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPI SSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVL EQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKVESKDRKANAHFILKLLCDSVVLQP YLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCP SGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHD CKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLV QTVARQTVEHCQYRPPRIREDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN KDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQ NKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPY AVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSMLDEP LERTTNSSHANGAAQAPRSMQWAVRNNASSYLTSASSLARAYSIVIRQISDLMGLIPKYN HLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPG HPNHPLHASQNSARRMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALI YWIKAMNQQTTETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARK EDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSPPLTSFRPQCSFMGMVISHD MLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLE VDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAF LSNEKLPNLECIQNDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNEL CPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAID LCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKN SLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTE RQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQ KLLLAIKTK

>8e0q-a1-m1-cB (length=1689) [Search sequence]

MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF LLEDGRVCRIGFSVQPDRLSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLS SVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAK NKPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNEEQWSLREVVFVE DVTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQE NNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPI SSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVL EQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKVESKDRKANAHFILKLLCDSVVLQP YLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCP SGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHD CKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLV QTVARQTVEHCQYRPPRIREDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN KDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQ NKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPY AVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSMLDEP LERTTNSSHANGAAQAPRSMQWAVRNNASSYLTSASSLARAYSIVIRQISDLMGLIPKYN HLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPG HPNHPLHASQNSARRMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALI YWIKAMNQQTTETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARK EDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSPPLTSFRPQCSFMGMVISHD MLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLE VDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAF LSNEKLPNLECIQNDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNEL CPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAID LCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKN SLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTE RQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQ KLLLAIKTK

Structure information

PDB ID	8e0q (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a C2 symmetric dimeric form
Assembly ID	1
Resolution	2.66Å
Method of structure determination	ELECTRON MICROSCOPY
Number of inter-chain contacts	520
Sequence identity between the two chains	1.0
PubMed citation	37040767

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	A	B
UniProt accession	O95071	O95071
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:8e0qA	BioLiP:8e0qB

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black]   [White]   Download: 8e0q-a1-m1-cA_8e0q-a1-m1-cB.pdb.gz

Full biological assembly Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black quality]   [White quality]   Download: 8e0q-assembly1.cif.gz

Similar dimers

Other dimers with similar sequences and structures	8d4x/1/1:B/1:A 8ewi/1/1:A/1:B 8ewi/1/1:C/1:D
Other dimers with similar sequences but different poses	8ewi/1/1:B/1:D 8ewi/1/1:A/1:C