8ewi/1/1:B/1:D

Sequences
>8ewi-a1-m1-cB (length=1775) [Search sequence]
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ
WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLS
SVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAK
NKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSC
RFQLRSPESLKNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSS
GPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKG
VHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDG
NGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQT
LMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN
KVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILE
TAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIF
ECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDL
LYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDSDMPDHDLEPPRF
AQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFT
HCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMA
SSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSI
DAMQGSEELFSVEPLPPRPSSMLDEPLERTTNSSHANGAAQAPRSMQWAVRNNASSYLTS
ASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWN
WMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRMSARGDFLNYALSLMRSHN
DEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTETGQNHPFFRRSDSMTFLGCIPP
NPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEV
LPTKMSPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGG
FEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRV
KVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNDNAPLFYQPGKRGFYTPRPG
KNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESL
RQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYA
EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDE
SGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDD
QHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTK
>8ewi-a1-m1-cD (length=1775) [Search sequence]
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ
WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLS
SVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAK
NKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSC
RFQLRSPESLKNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSS
GPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKG
VHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDG
NGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQT
LMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN
KVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILE
TAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIF
ECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDL
LYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDSDMPDHDLEPPRF
AQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFT
HCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMA
SSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSI
DAMQGSEELFSVEPLPPRPSSMLDEPLERTTNSSHANGAAQAPRSMQWAVRNNASSYLTS
ASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWN
WMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRMSARGDFLNYALSLMRSHN
DEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTETGQNHPFFRRSDSMTFLGCIPP
NPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEV
LPTKMSPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGG
FEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRV
KVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNDNAPLFYQPGKRGFYTPRPG
KNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESL
RQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYA
EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDE
SGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDD
QHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTK
Structure information
PDB ID 8ewi (database links: RCSB PDB PDBe PDBj PDBsum)
Title Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form
Assembly ID 1
Resolution 3.5Å
Method of structure determination ELECTRON MICROSCOPY
Number of inter-chain contacts 42
Sequence identity between the two chains 1.0
PubMed citation 37040767
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID B D
UniProt accession O95071 O95071
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:8ewiB BioLiP:8ewiD
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
Color: [By chain]   [By residue index]  
Spin: [Spin off]   [Spin on]   [Reset]
Render: [Low quality]   [High quality]  
Background: [Black]   [White]  
Download: 8ewi-a1-m1-cB_8ewi-a1-m1-cD.pdb.gz
Full biological assembly
Color: [By chain]   [By residue index]  
Spin: [Spin off]   [Spin on]   [Reset]
Render: [Low quality]   [High quality]  
Background: [Black quality]   [White quality]  
Download: 8ewi-assembly1.cif.gz
Similar dimers
Other dimers with similar sequences but different poses
  • 8e0q/1/1:A/1:B 8d4x/1/1:B/1:A 8ewi/1/1:A/1:B 8ewi/1/1:C/1:D
    		•

    [Back to Home]