Full-chain sequence requirement:
Please provide the full-chain sequecne if your domain structures contain the following conditions.
|Some linkers between domains are overlapped.|
|Gaps or missed residues in the linker or core region.|
|Discontinuous domain with the sequence disconnect in the full sequence.|
|You do not know how the domain structures connect, e.g. domain A + domain B or domain B + domain A.|
|When you are not sure if your domain structures contain the abvove conditions.|
DEMO can deal with these conditions according to the full-chain sequence automatically. For example, search for the optimal docking regions when there are overlap between domains or generate the structure of the missed residues.
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