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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Caudel LS-122 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Methyl diazepinone 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one Dipam D07JVL Morosan 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Drenian Dialag Nerozen AC1L1EZE Duxen Diastat Acudial Notense Anlin Evacalm Diazepam (intranasal, epilepsy) NSC77518 Apo-diazepam Gihitan Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Paxate Baogin HSDB 3057 Diazepam [USAN:USP:INN:BAN:JAN] Pms-Diazepam Betapam KBio1_000967 Quetinil C-17931 LA-111 11100-37-1 Ro 5-2805 Saromet Serenzin SMR000058398 STK735517 Trankinon UNII-Q3JTX2Q7TU Valium (TN) Velium ZB000640 Ruhsitus CCRIS 6009 Mandrozep 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diazepan Condition Methyldiazepinone, pharmaceutical 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on Disopam DEA No. 2765 NCGC00178168-02 A3662/0155188 DSSTox_RID_75566 Diapax Neurolytril Aliseum EINECS 207-122-5 Diazapam Novodipam Ansiolisina Faustan, Diazepam 1.0 mg/ml in Methanol Paceum Arzepam Gubex Diazepam Rectubes Placidox 10 BCP9000199 Iazepam Diazepam-Eurogenerics Prozepam BIDD:PXR0158 Kiatrium Radizepam Calmocitene Lembrol Sedipam Sibazon Spectrum3_001780 Tensopam Tranquirit Valaxona Valuzepam W-5055 Zipan Ceregulart Mentalium 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one Diazetard D-Pam MLS001424086 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Domalium Diacepan NCGC00260007-01 AB02310 Duksen Diastat Nixtensyn AN-23449 Euphorin P Diazemulus NSC-77518 Anxionil FT-0632135 Diazepam Elmu Paranten Atilen HMS503A15 Diazepam Stada Plidan Benzopin Jinpanfan Diazepamu Q-Pam Relanium BRN 0754371 LA 111 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Reliver Calmpose Lizan S.A.R.L. Serenack Simasedan Stesolid Tox21_202458 Trazepam Valitran Vazen Wy 3467 CC-26451 Mandro 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Diazepamum CHEMBL12 Methyldiazepinone 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one Dipaz D0Y1YC NC00247 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one DSSTox_CID_406 Dialar Nervium AKOS003367969 DZP Diastat, Valium Novazam Ansilive Faustal Diazepam (JP17/USP/INN) Oprea1_126223 Apozepam Gradual Diazepam Intensol Paxel BCP0726000176 HY-17027 Diazepam, European Pharmacopoeia (EP) Reference Standard Pomin Bialzepam KBio3_002780 Quiatril C06948 La-Iii 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Ro 5-2807 SCHEMBL21442 Servizepam Solis T-quil Tranqdyn Unisedil Valium R Vival Zepaxid 439-14-5 Centrazepam MCULE-8990989144 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Diazepan leo CPD000058398 Metil Gobanal 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one DivK1c_000967 Desconet NCGC00178168-03 A826456 DTXSID4020406 Diapine NINDS_000967 Alupram Elcion CR Diazem NSC 169897 Antenex Freudal Diazepam Dak Pacitran Assival HMS2051N04 Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Placidox 2 BDBM50000766 IDI1_000967 Diazepam-Lipuro Psychopax BRD-K16508793-001-01-8 Kratium Relaminal Calmociteno Levium S.A. R.L Seduksen Sibazone Spectrum4_000576 Tox21_113071 Tranquo-puren Valeo Vanconin Winii Lovium 53320-84-6 CHEBI:49575 Metamidol 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Dienpax D00293 Mono (2-ethylhexyl) phthalate 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Doval Diaceplex Nellium AC-10561 Dupin Diastat (TN) Noan An-Ding Eurosan NSC169897 Apaurin Gewacalm Diazepam Fabra Parzam Azedipamin Horizon Diazepam [USAN:INN:BAN:JAN] Plumiaz Best [Pharaceutical] Kabivitrum Diazepamu [Polish] Q3JTX2Q7TU BSPBio_003279 LA III 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one Renborin CAS-439-14-5 SAM001246536 Serenamin Sipam Stesolin Tranimul Umbrium Valium Vazepam WY-3467 CCG-100997 Mandro-Zep 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Diazepamum [INN-Latin] Chuansuan Methyldiazepinone (pharmaceutical) 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Dipezona DB00829 NCGC00178168-01 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. DSSTox_GSID_20406 Diapam neurolytr il Alboral e-Pam Diatran Novo-Dipam Ansiolin Faustan Diazepam 0.1 mg/ml in Methanol Ortopsique Armonil GTPL3364 Diazepam Nordic Paxum BCP23002 I06-0194 Diazepam, United States Pharmacopeia (USP) Reference Standard Pro pam BIDD:GT0105 KBioGR_001012 Quievita Calmaven Lamra 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Ro-52807 Sedapam Setonil Sonacon Tensium Tranquase Usempax ap Valrelease Vivol ZINC6427 5-24-04-00300 (Beilstein Handbook Reference) Cercine Medipam 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine Diazepin CS-0653 MLS000759402 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Dizac Desloneg NCGC00178168-04 AAOVKJBEBIDNHE-UHFFFAOYSA-N Ducene Diaquel Nivalen Amiprol Eridan Diazemuls NSC-169897 Anxicalm Frustan Diazepam Desitin Paralium Atensine HMS3393N04 Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Placidox 5 Bensedin InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Diazepam-ratiopharm Q-pam Britazepam Kratium 2 (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Relanium Calmod Liberetas S.a. r.l. Seduxen Sico Relax Spectrum5_001890 Tox21_113071_1 Tranquo-tablinen Valiquid Vatran WLN: T67 GNV JN IHJ CG G1 KR [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
441686	Adenosine receptor A3	P0DMS8	ADORA3	Homo sapiens (Human)	318
553247	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
402	Cholecystokinin receptor type A	P30551	Cckar	Rattus norvegicus (Rat)	444
404	Cholecystokinin receptor type A	Q63931	CCKAR	Cavia porcellus (Guinea pig)	430
403	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
555480	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
555481	Gamma-aminobutyric acid type B receptor subunit 1	Q9Z0U4	Gabbr1	Rattus norvegicus (Rat)	991
407	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
553248	Thyrotropin-releasing hormone receptor	Q01717	Trhr	Rattus norvegicus (Rat)	412

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