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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Paralium ZINC6427 HMS3393N04 Apaurin Placidox 5 Diazepam Fabra InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Sedapam Azedipamin Q-pam Diazepam [USAN:INN:BAN:JAN] Kratium 2 Setonil Best [Pharaceutical] Relanium Diazepamu [Polish] Liberetas Sonacon BSPBio_003279 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one Medipam Tensium CAS-439-14-5 Diazepin 53320-84-6 MLS000759402 Tranquase CHEBI:49575 Dizac 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one NCGC00178168-04 Usempax ap D00293 Ducene 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Nivalen Valrelease Diaceplex Eridan AC-10561 NSC-169897 Vivol Diastat (TN) Frustan An-Ding Gihitan Ansiolin Paxate Diazepam 0.1 mg/ml in Methanol HSDB 3057 S.a. r.l. Armonil Pms-Diazepam Diazepam Nordic KBio1_000967 Seduxen BCP23002 Quetinil Diazepam, United States Pharmacopeia (USP) Reference Standard LA-111 Sico Relax BIDD:GT0105 Ro 5-2805 LS-122 Spectrum5_001890 Calmaven 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Methyl diazepinone Tox21_113071_1 CCG-100997 Dipam 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Morosan Tranquo-tablinen Chuansuan Drenian 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Nerozen Valiquid DB00829 Duxen 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Notense Vatran Diapam Evacalm Alboral NSC77518 WLN: T67 GNV JN IHJ CG G1 KR Diatran Diazemuls Gubex Anxicalm Placidox 10 Diazepam Desitin Iazepam Saromet Atensine Prozepam Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Kiatrium Serenzin Bensedin Radizepam Diazepam-ratiopharm Lembrol SMR000058398 Britazepam Ruhsitus (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Mandrozep STK735517 Calmod Diazepan 5-24-04-00300 (Beilstein Handbook Reference) Methyldiazepinone, pharmaceutical Trankinon Cercine Disopam 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine NCGC00178168-02 UNII-Q3JTX2Q7TU CS-0653 DSSTox_RID_75566 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Neurolytril Valium (TN) Desloneg EINECS 207-122-5 AAOVKJBEBIDNHE-UHFFFAOYSA-N Novodipam Velium Diaquel Faustan, Amiprol Paceum ZB000640 Anlin Paranten Zipan Diazepam (intranasal, epilepsy) HMS503A15 Apo-diazepam Plidan Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Jinpanfan Sedipam Baogin Q-Pam Relanium Diazepam [USAN:USP:INN:BAN:JAN] LA 111 Sibazon Betapam Reliver Lizan Spectrum3_001780 C-17931 11100-37-1 Mentalium Tensopam Caudel Diazetard 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one MLS001424086 Tranquirit Domalium 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one NCGC00260007-01 Valaxona D07JVL Duksen 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Nixtensyn Valuzepam Dialag Euphorin P AC1L1EZE NSC-77518 W-5055 Diastat Acudial FT-0632135 Gradual Ansiolisina Paxel Diazepam 1.0 mg/ml in Methanol HY-17027 S.A.R.L. Arzepam Pomin Diazepam Rectubes KBio3_002780 Serenack BCP9000199 Quiatril Diazepam-Eurogenerics La-Iii Simasedan BIDD:PXR0158 Ro 5-2807 Mandro Stesolid Calmocitene Diazepamum Methyldiazepinone Tox21_202458 CCRIS 6009 Dipaz 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one NC00247 Trazepam Condition DSSTox_CID_406 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on Nervium Valitran DEA No. 2765 DZP A3662/0155188 Novazam Vazen Diapax Faustal Aliseum Oprea1_126223 Wy 3467 Diazapam Pacitran Zepaxid Diazemulus HMS2051N04 Anxionil Placidox 2 Diazepam Elmu IDI1_000967 SCHEMBL21442 Atilen Psychopax Diazepam Stada Kratium Servizepam Benzopin Relaminal Diazepamu Levium Solis BRN 0754371 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one MCULE-8990989144 T-quil Calmpose Diazepan leo Metil Gobanal Tranqdyn Ceregulart DivK1c_000967 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one NCGC00178168-03 Unisedil D-Pam DTXSID4020406 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine NINDS_000967 Valium R Diacepan Elcion CR AB02310 NSC 169897 Vival Diastat Freudal AN-23449 Ansilive Parzam Diazepam (JP17/USP/INN) Horizon S.A. R.L Apozepam Plumiaz Diazepam Intensol Kabivitrum Seduksen BCP0726000176 Q3JTX2Q7TU Diazepam, European Pharmacopoeia (EP) Reference Standard LA III Sibazone Bialzepam Renborin Lovium Spectrum4_000576 C06948 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Metamidol Tox21_113071 CC-26451 Dienpax 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Mono (2-ethylhexyl) phthalate Tranquo-puren CHEMBL12 Doval 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one Nellium Valeo D0Y1YC Dupin 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Noan Vanconin Dialar Eurosan AKOS003367969 NSC169897 Winii Diastat, Valium Gewacalm Diazem GTPL3364 Antenex Paxum Diazepam Dak I06-0194 SAM001246536 Assival Pro pam Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material KBioGR_001012 Serenamin BDBM50000766 Quievita Diazepam-Lipuro Lamra Sipam BRD-K16508793-001-01-8 Ro-52807 Mandro-Zep Stesolin Calmociteno Diazepamum [INN-Latin] 439-14-5 Methyldiazepinone (pharmaceutical) Tranimul Centrazepam Dipezona 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one NCGC00178168-01 Umbrium CPD000058398 DSSTox_GSID_20406 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one neurolytr il Valium Desconet e-Pam A826456 Novo-Dipam Vazepam Diapine Faustan Alupram Ortopsique WY-3467 [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
441686	Adenosine receptor A3	P0DMS8	ADORA3	Homo sapiens (Human)	318
553247	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
402	Cholecystokinin receptor type A	P30551	Cckar	Rattus norvegicus (Rat)	444
404	Cholecystokinin receptor type A	Q63931	CCKAR	Cavia porcellus (Guinea pig)	430
403	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
555480	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
555481	Gamma-aminobutyric acid type B receptor subunit 1	Q9Z0U4	Gabbr1	Rattus norvegicus (Rat)	991
407	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
553248	Thyrotropin-releasing hormone receptor	Q01717	Trhr	Rattus norvegicus (Rat)	412

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