Online Services

●I-TASSER ●QUARK ●LOMETS ●COACH ●COFACTOR ●MUSTER ●SEGMER ●FG-MD ●ModRefiner ●REMO ●SPRING ●COTH ●BSpred ●SVMSEQ ●ANGLOR ●BSP-SLIM ●SAXSTER ●ThreaDom ●EvoDesign ●GPCR-I-TASSER ●BindProf ●BindProfX ●ResQ ●IonCom ●STRUM

●TM-score ●TM-align ●MMalign ●NWalign ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●I-TASSER-MR

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●TM-fold ●DECOYS ●POTENTIAL ●RW ●HPSF ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12

MetaGO standalone program

• structure-based pipeline in MetaGO
• PPI-homolog and sequence-based pipelines & the final consensus method

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MetaGO benchmark data

Datasets of representative UniProt proteins with experimental Gene Ontology (GO) annotation and structure models predicted by I-TASSER.

• training dataset: 1244 E. coli proteins for training parameters in MetaGO.
• testing dataset: 1000 CAFA3 targets for testing MetaGO.

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Reference:

• Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. MetaGO: Predicting Gene Ontology of non-homologous proteins through low-resolution protein structure prediction and protein-protein network mapping. Journal of Molecular Biology, 430, no. 15 (2018): 2256-2265. [PDF] [Support Information] [Figures]