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GPCR

NameOrexin receptor type 1
SpeciesRattus norvegicus (Rat)
GeneHcrtr1
Synonymhypocretin (orexin) receptor 1
hypocretin receptor 1
Hypocretin receptor type 1
Hctr1
orexin receptor type 1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length416
Amino acid sequenceMEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
UniProtP56718
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075232
IUPHAR321
DrugBankN/A

Known ligands

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Total entries: 440
Page:  / 5 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5173192D structureCHEMBL3663396C25H26N2O3402.4944 / 04.9Yes
28992D structureDORA-22C23H22F2N4O2424.4527 / 03.6Yes
5574792D structureSCHEMBL16031595C21H24F3N3O2407.4377 / 14.5Yes
4636882D structureCHEMBL3704949C21H24F3N3O2407.4377 / 14.5Yes
5479702D structureCHEMBL3893886C21H24F3N3O2407.4377 / 14.5Yes
5173722D structureCHEMBL3663428C23H20F2N4O2422.4367 / 03.5Yes
5173732D structureCHEMBL3663490C21H19F3N6O428.4198 / 14.0Yes
5173752D structureCHEMBL3663517C20H19F3N8O444.42210 / 13.0Yes
5173802D structureCHEMBL3663420C21H19F2N5O2411.4137 / 03.5Yes
118512D structureSCHEMBL7907941C24H23N5O2413.4815 / 04.5Yes
5173842D structureCHEMBL3659204C24H21FN6O2444.477 / 03.8Yes
5173852D structureCHEMBL3663429C22H22FN5O2407.4496 / 03.8Yes
5173912D structureCHEMBL3663548C22H18F4N6O458.42110 / 12.6Yes
5174002D structureCHEMBL3659219C21H24BrN3O3446.3455 / 04.0Yes
5174022D structureCHEMBL3663426C24H23FN4O2418.4726 / 03.7Yes
5174042D structureCHEMBL3663383C22H24N4O2376.464 / 04.3Yes
5174052D structureCHEMBL3663546C22H18F4N6O458.42110 / 12.7Yes
5364072D structureCHEMBL3905361C20H21F3N8O446.43810 / 12.8Yes
4650052D structureCHEMBL3691823C23H18F4N4O2458.4179 / 03.9Yes
5174142D structureCHEMBL3663509C20H20N6O360.4215 / 13.1Yes
5174152D structureCHEMBL3659242C24H22N6O2426.486 / 03.9Yes
4650422D structureCHEMBL3669051C20H20F3N7O2447.42210 / 03.2Yes
5174232D structureCHEMBL3663478C20H19F3N8O444.42210 / 12.6Yes
185212D structureSCHEMBL1717163C21H22FN3O2367.4244 / 13.7Yes
5174282D structureCHEMBL3663496C21H23N7O389.4636 / 13.3Yes
5174292D structureCHEMBL3663538C21H18F4N6O2462.40911 / 13.4No
5481222D structureCHEMBL3896726C23H19F4N5O457.4339 / 14.1Yes
5579212D structureSCHEMBL16040151C23H19F4N5O457.4339 / 14.1Yes
5174342D structureCHEMBL3663486C23H19F4N5O457.4339 / 14.1Yes
5174382D structureCHEMBL3663415C22H22FN5O2407.4496 / 03.8Yes
5174402D structureCHEMBL3663519C22H20F3N7O455.44510 / 13.0Yes
5174442D structureCHEMBL3659226C21H22N6O2390.4476 / 02.6Yes
5174452D structureCHEMBL3663526C21H20F3N7O2459.43310 / 12.9Yes
4658272D structureCHEMBL3691837C21H18F3N3O2401.3896 / 14.0Yes
4662492D structureCHEMBL3704970C25H25N7O439.5236 / 14.3Yes
5481852D structureCHEMBL3951401C25H25N7O439.5236 / 14.3Yes
5580912D structureSCHEMBL16032036C25H25N7O439.5236 / 14.3Yes
5174642D structureCHEMBL3663554C23H19BrFN7O508.3557 / 14.1No
5174682D structureCHEMBL3663502C25H23N7O437.5077 / 13.1Yes
5174902D structureCHEMBL3663520C20H20FN7O393.4267 / 12.9Yes
340932D structureSCHEMBL7917696C24H22FN5O2431.4716 / 04.4Yes
4678802D structureCHEMBL3669032C24H24N6O2428.4967 / 13.8Yes
5175202D structureCHEMBL3663418C21H21FN6O3424.4368 / 03.0Yes
407392D structureOrexin receptor antagonist 10C19H18N6O2S394.4537 / 03.0Yes
407902D structureSCHEMBL2341479C24H27FN4O2422.5045 / 05.0Yes
4680002D structureCHEMBL3669026C22H23N7O2417.4737 / 13.9Yes
4683292D structureCHEMBL3691851C23H19F4N5O457.4339 / 13.9Yes
4683762D structureCHEMBL3691807C20H18F3N7O2445.40610 / 02.5Yes
5175542D structureCHEMBL3663562C22H21FN6O404.4497 / 12.5Yes
5175652D structureCHEMBL3663499C23H22N8O426.4847 / 13.1Yes
5175692D structureCHEMBL3663408C22H26FN5O2411.4817 / 03.0Yes
4690592D structureCHEMBL3691824C21H18F3N5O2429.4038 / 03.0Yes
4691012D structureCHEMBL3691834C23H21F3N4O3458.4418 / 13.8Yes
5175862D structureCHEMBL3663549C22H18F4N6O458.42110 / 12.6Yes
4693852D structureCHEMBL3691806C20H17F3N6O2430.3919 / 02.8Yes
4698152D structureCHEMBL3669048C20H20F3N7O2447.42210 / 03.1Yes
560272D structureOrexin receptor antagonist 31C21H19N5O2S405.4767 / 03.0Yes
5176152D structureCHEMBL3663413C22H22FN5O3423.4487 / 03.4Yes
590602D structureOrexin receptor antagonist 17C21H21N7O3419.4458 / 02.6Yes
4704762D structureCHEMBL3691825C21H19F3N6O2444.4189 / 03.5Yes
4706692D structureCHEMBL3704939C21H22F3N7O445.459 / 13.8Yes
5176442D structureCHEMBL3659221C20H21N7O2391.4357 / 02.0Yes
4707762D structureCHEMBL3691850C21H18F4N6O446.419 / 13.9Yes
5376212D structureCHEMBL3977337C24H25N3O3403.4825 / 04.2Yes
5176622D structureCHEMBL3663390C24H25N3O3403.4825 / 04.2Yes
4713202D structureCHEMBL3691815C24H21F3N4O3470.4529 / 03.8Yes
4714822D structureCHEMBL3691847C21H20F3N7O443.4349 / 13.5Yes
4715492D structureCHEMBL3704956C21H24N6O376.4645 / 13.7Yes
701362D structureOrexin receptor antagonist 34C23H20FN5O2417.4447 / 03.1Yes
4716092D structureCHEMBL3669041C20H22BrN7O456.3486 / 13.6Yes
726672D structureOrexin receptor antagonist 3C22H21N5O3403.4427 / 03.3Yes
4718952D structureCHEMBL3691840C22H18BrFN4O2469.3146 / 03.7Yes
5378462D structureCHEMBL3973097C21H17F2N5O2409.3977 / 13.3Yes
4724252D structureCHEMBL3691852C20H18F3N7O429.4079 / 12.8Yes
5177122D structureCHEMBL3663459C19H20N4O2S368.4555 / 04.0Yes
5177172D structureCHEMBL3663407C21H20FN5O3409.4218 / 02.5Yes
4726622D structureCHEMBL3704958C23H23N7O413.4856 / 14.0Yes
5177202D structureCHEMBL3663527C22H18F4N6O458.42110 / 13.0Yes
5177242D structureCHEMBL3663551C22H18F4N6O458.42110 / 13.0Yes
4729562D structureCHEMBL3691827C20H17F3N6O2430.3919 / 03.1Yes
5598712D structureUS9475819, 10AC22H22FN5O2407.4496 / 03.8Yes
5177382D structureCHEMBL3659180C22H22FN5O2407.4496 / 03.8Yes
5380432D structureUS9475819, 10AC22H22FN5O2407.4496 / 03.8Yes
832152D structureOrexin receptor antagonist 1C21H20N6O2388.4316 / 03.0Yes
5177442D structureCHEMBL3663573C24H25F3N6O2486.4999 / 13.3Yes
4735472D structureCHEMBL3669039C20H19F4N7O449.41410 / 13.2Yes
4736222D structureCHEMBL3691826C21H19F3N6O2444.4189 / 03.5Yes
4736492D structureCHEMBL3669050C20H19F3N6O2432.4079 / 03.5Yes
5177742D structureCHEMBL3663529C21H20F3N7O443.4349 / 13.3Yes
5177802D structureCHEMBL3659238C22H22FN5O2407.4496 / 03.1Yes
894532D structureSCHEMBL1716434C24H25FN4O2420.4886 / 03.5Yes
5177992D structureCHEMBL3663458C21H25N3O3367.4495 / 03.3Yes
5178042D structureCHEMBL3663395C23H23N3O3389.4555 / 03.6Yes
931492D structureOrexin receptor antagonist 6C21H19FN6O2406.4217 / 03.1Yes
4748322D structureCHEMBL3640038C20H23N7O377.4526 / 13.0Yes
5178292D structureCHEMBL3663484C21H20F3N7O443.4349 / 13.1Yes
4750182D structureCHEMBL3669024C20H21F3N8O446.43810 / 13.2Yes
5178432D structureCHEMBL3663406C22H22FN5O3423.4488 / 02.9Yes
5178472D structureCHEMBL3659243C24H25N3O3403.4825 / 03.9Yes
4754562D structureCHEMBL3691843C20H19BrN6O2455.3166 / 03.3Yes

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