Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	LY307452
Molecular formula	C21H25NO4
IUPAC name	(2S,4S)-2-amino-4-(4,4-diphenylbutyl)pentanedioic acid
Molecular weight	355.434
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	1.4
Synonyms	LY-307,452 PDSP1_000257 (2S,4S)-2-amino-4-(4,4-diphenylbutyl)pentanedioic acid GTPL3350 AC1O44IF LY-307452 (2s,4s)-2-amino-4-(4,4-di-phenylbut-1-yl)-pentane-1,5-dioic acid CHEMBL39338 PDSP2_000256 2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid LY 307452 BDBM50049748 (2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid D0OV2V SCHEMBL4257120 [ Show all ]
Inchi Key	DWLOVDOPFJPWNE-HKUYNNGSSA-N
Inchi ID	InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
PubChem CID	6324634
ChEMBL	CHEMBL39338
IUPHAR	N/A
BindingDB	50049748
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
70680	Metabotropic glutamate receptor 1	Q13255	GRM1	Homo sapiens (Human)	1194
70677	Metabotropic glutamate receptor 2	Q14416	GRM2	Homo sapiens (Human)	872
70682	Metabotropic glutamate receptor 3	Q14832	GRM3	Homo sapiens (Human)	879
70676	Metabotropic glutamate receptor 4	Q14833	GRM4	Homo sapiens (Human)	912
70679	Metabotropic glutamate receptor 5	P41594	GRM5	Homo sapiens (Human)	1212
70681	Metabotropic glutamate receptor 7	Q14831	GRM7	Homo sapiens (Human)	915
70678	Metabotropic glutamate receptor 8	O00222	GRM8	Homo sapiens (Human)	908

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218