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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Orexin receptor antagonist 14
Molecular formula	C19H18N6O2S
IUPAC name	2-[(3R,6R)-6-methyl-1-[3-(triazol-2-yl)thiophene-2-carbonyl]piperidin-3-yl]oxypyridine-4-carbonitrile
Molecular weight	394.453
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.0
Synonyms	SCHEMBL14876902 CHEMBL3642128 US20130102619, 14 BDBM97383
Inchi Key	HARDDASKVMKGRN-UKRRQHHQSA-N
Inchi ID	InChI=1S/C19H18N6O2S/c1-13-2-3-15(27-17-10-14(11-20)4-6-21-17)12-24(13)19(26)18-16(5-9-28-18)25-22-7-8-23-25/h4-10,13,15H,2-3,12H2,1H3/t13-,15-/m1/s1
PubChem CID	71526390
ChEMBL	CHEMBL3642128
IUPHAR	N/A
BindingDB	97383
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
110091	Orexin receptor type 1	P56718	Hcrtr1	Rattus norvegicus (Rat)	416
110092	Orexin receptor type 1	O43613	HCRTR1	Homo sapiens (Human)	425
110090	Orexin receptor type 2	O43614	HCRTR2	Homo sapiens (Human)	444
110093	Orexin receptor type 2	P56719	Hcrtr2	Rattus norvegicus (Rat)	460

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