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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●COACH ●COFACTOR ●MetaGO ●MUSTER ●CEthreader ●SEGMER ●FG-MD ●ModRefiner ●REMO ●DEMO ●SPRING ●COTH ●Threpp ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●CR-I-TASSER ●GPCR-I-TASSER ●MAGELLAN ●BindProf ●BindProfX ●SSIPe ●ResQ ●IonCom ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

Other GPCR-related resources GPCR-I-TASSER: On-line server for GPCR structure prediction GPCR-HGmod: Structur models of GPCRs in the human genome GPCR-EXP: collection of experimentally solved GPCRs GLASS: GPCR-ligand association database GPCR resources from other laboratories GPCRDB: information system for GPCRss TinyGPAP mutant database GPCR-OKB: oligomerization knowledge base GPCR natural variants database GLIDA: GPCR-ligand database IUPHAR GPCR database gpDB: G proteins and their interactions with GPCRs SEVENS: GPCR genes database GDD: GPCR decoy database Summary of activation changes in GPCR TMs

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11002 entries in GPCR-RD.
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Swiss-Prot ID	Experimental Data	Swiss-Prot ID	Experimental Data	Swiss-Prot ID	Experimental Data
adrb2_mesau	C327V	adrb2_mesau	E107A	drd1_human	S199A  [Orientation Restraint]
drd2_mouse	S193A	hrh1_human	D107N  [Orientation Restraint]	hrh1_human	D107E  [Orientation Restraint]
opsd_human	P53R  [Orientation Restraint]	opsd_human	P171L  [Orientation Restraint]	opsd_human	H211P  [Orientation Restraint]
opsd_human	H211R  [Orientation Restraint]	opsd_human	P267L  [Orientation Restraint]	nk1r_human	H197Q
nk1r_human	H197F	nk1r_human	H197K	nk1r_human	H197S
nk1r_human	H197A	nk1r_human	H197Y	nk1r_human	T201A
nk1r_human	Q284A  [Orientation Restraint]	nk1r_human	Y287Q  [Orientation Restraint]	nk1r_human	Y287F  [Orientation Restraint]
nk1r_human	Y287W  [Orientation Restraint]	nk1r_human	Y287A  [Orientation Restraint]	nk1r_human	Y287S  [Orientation Restraint]
nk1r_human	Y287H  [Orientation Restraint]	nk1r_human	H265Y  [Orientation Restraint]	nk1r_human	H265A  [Orientation Restraint]
nk1r_human	H265Q  [Orientation Restraint]	nk1r_human	H265F  [Orientation Restraint]	nk1r_human	H265S  [Orientation Restraint]
nk2r_human	H267Y  [Orientation Restraint]	ednra_human	S167A  [Orientation Restraint]	ednra_human	V225A
agtr1_human	N295S  [Orientation Restraint]	trfr_mouse	D165A	trfr_mouse	D195A
mshr_human	H209A	ta2r_human	L291F	ta2r_human	R295Q
ta2r_human	W299L	ta2r_human	W299R	gnrhr_mouse	D292N
gnrhr_mouse	E294Q	trfr_mouse	N110S	nk2r_human	L160F  [Orientation Restraint]
nk2r_human	C167G  [Orientation Restraint]	nk2r_human	L292I  [Orientation Restraint]	nk2r_human	L292S  [Orientation Restraint]
nk1r_human	S169A	acm1_human	S368A  [Orientation Restraint]	adrb2_human	C125V  [Orientation Restraint]
adrb2_human	N322A  [Orientation Restraint]	adrb2_human	N322D  [Orientation Restraint]	pe2r3_mouse	R309E
pe2r3_mouse	R309K	pe2r3_mouse	R309V	npy1r_human	L43A
npy1r_human	F41A	npy1r_human	F286A	oprd_rat	L125I
ssr2_rat	D122A	ssr2_rat	D122E	v1ar_rat	K128A
aa2ar_human	N253Q	aa2ar_human	N253S	aa2ar_human	H278Q  [Orientation Restraint]
aa2ar_human	H278F  [Orientation Restraint]	aa2ar_human	H278Y  [Orientation Restraint]	lshr_human	M571I
agtr1_human	N111A  [Orientation Restraint]	agtr1_human	D278A	agtr1_human	D281A
agtr1_human	V280A	ednra_human	E220N	ednra_human	Y263F  [Orientation Restraint]
ednra_human	R326Q  [Orientation Restraint]	ednra_human	H323F  [Orientation Restraint]	ednra_human	F315L  [Orientation Restraint]
ednra_human	D351N  [Orientation Restraint]	oprk_rat	E297K	ednrb_human	W276C  [Orientation Restraint]
v2r_human	Y128S  [Orientation Restraint]	v2r_human	R202C	p2ry2_mouse	R292L
p2ry2_mouse	K289R	p2ry2_mouse	K289I	drd2_human	I109C  [Orientation Restraint]
drd2_human	V111C  [Orientation Restraint]	drd2_human	T112C  [Orientation Restraint]	drd2_human	V115C  [Orientation Restraint]
drd2_human	M116C  [Orientation Restraint]	drd2_human	T119C  [Orientation Restraint]	drd2_human	A120C  [Orientation Restraint]

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Reference:

Jian Zhang and Yang Zhang, GPCRRD: G protein-coupled receptor spatial restraint database for 3-D structure modeling and function annotation, Bioinformatics, 26:3004-3005 (2010).