FURNA (Functions of RNAs) is a database of ligand-RNA interactions and Gene Ontology annotations for RNAs in the Protein Data Bank (PDB). Each entry in FURNA contains a comprehensive list of annotations on:

Ligand-binding sites;

Gene Ontology (GO) terms and Enzyme Commission (EC) numbers;

Rfam families;

Motifs for protein binding from the ATtRACT database;

Secondary structure assignments from CSSR and DSSR;

Cross reference to external databases, including RCSB PDB, PDBe, PDBj, PDBsum, NAKB, DNATCO, BGSU RNA, QuickGO, ChEMBL, DrugBank, ZINC, UniProt, PubMed, RNAcentral.

Database statistics

The database is updated weekly and the current version (2025-02-22) contains:

Number of ligand-RNA interactions: 458382

Number of regular ligand-RNA interactions: 34976

Number of metal-ion-RNA interactions: 225015

Number of protein-RNA interactions: 168241

Number of DNA-RNA interactions: 1073

Number of RNA-RNA interactions: 29077

Number of types of ligands: 595

Number of RNAs: 19236

Number of RNAs with Enzyme Commission (EC) numbers: 95

Number of RNAs with Gene Ontology (GO) terms: 11384 (10585 with Molecular Function, 3576 with Biological Process, and 7645 with Cellular Component)

Number of RNAs with ATtRACT motifs for protein binding: 1853

Number of RNAs with Rfam families: 11578

View an example ligand-RNA interaction

Search name

PDB ID
PDB Chain ID
Ligand ID
Ligand name
RNA name
RNAcentral accession
Rfam family
Taxon
EC number
GO term
ATtRACT motif
PubMed ID

  

Search sequence (quick search by BLAST)

Paste your sequence here:     [Sample rna input] [Sample protein input] [Sample dna input]

Select Sequence type:     RNA     Protein     DNA
  

Search RNA sequence (sensitive search by Infernal)

Paste your sequence here:     [Sample rna input]

  

Search RNA structure (by US-align)

Paste your structure here:     [Example file]

Or upload PDB or mmCIF format file from your computer: (do not upload compressed file).